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Find Breast Cancer Clinical Trials That Are Right For You

The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.

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(Last updated: April 20, 2024)

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TP53

1

NEAREST SITE: 446 miles
Scripps- MD Anderson Cancer
San Diego,CA

VISITS: 5 visits per week for 3 or 5 weeks

PHASE: II

NCT ID: NCT02912312

The Risk of Developing Lymphedema When Using Hypofractionated Radiation For DCIS & Stage I-III Breast Cancer

Shortening Adjuvant Photon Irradiation to Reduce Edema (SAPHIRE): A Randomized Trial of Hypofractionated Versus Conventionally Fractionated Regional Nodal Irradiation for Invasive Breast Cancer Scientific Title

Purpose
To compare the effects (good and bad) and the risk of developing lymphedema when using hypofractionated radiation therapy of the lymph nodes to traditional radiation therapy of the lymph nodes.
Who is this for?
Women with DCIS or stage I, stage II, or stage III breast cancer. You must have had surgery as part of your treatment unless you had DCIS.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Shorter radiation schedule (hypofractionated)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">15 radiation treatments: 5 days a week, for 3 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires, blood draws, and arm measurements, 7 visits over 10.5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard radiation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">25 radiation treatments: 5 days a week, for 5 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires, blood draws, and arm measurements, 7 visits over 10.5 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that develops as a side effect of breast cancer treatments like surgery and radiation therapy. </li> <li class="seamTextUnorderedListItem">Giving the traditional amount of radiation in a shorter period of time is called hypofractionated whole-breast radiation.</li> <li class="seamTextUnorderedListItem">The hypofractionated radiation therapy used in this trial takes about 4 weeks.</li> <li class="seamTextUnorderedListItem">The tradiational radiation therapy used in this trial takes about 6 weeks.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02912312' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/lymphedema/how/treat_impact' target='_blank'>Breastcancer.org: Impact of Radiation Therapy on Lymphedema Risk</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/shorter-radiation-better-for-early-stage' target='_blank'>Breastcancer.org: Shorter Radiation for Early Stage Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li></ul>
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2

NEAREST SITE: 1500 miles
University of Kansas Medical Center
Kansas City,KS

VISITS: Daily visits for 1 month

PHASE: NA

NCT ID: NCT02958774

Hypofractionated Radiation To Treat Regional Lymph Nodes to Reduce Lymphedema Risk

Hypofractionated Radiation Therapy for Patients With Breast Cancer Receiving Regional Nodal Irradiation Scientific Title

Purpose
To learn whether hypofractionated radiation therapy is less likely to cause lymphedema than conventional radiation therapy.
Who is this for?
Women with stage II or stage III breast cancer that has spread to the lymph nodes (node positive) who will be treated with radiation after breast cancer surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy, daily, for 1 month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a swelling of the soft tissues in the arm and hand caused by a build-up of lymph fluid. </li> <li class="seamTextUnorderedListItem">Radiation therapy to the lymph nodes can result in scar tissue that blocks the lymph flow, increasing risk for <span class="highlight">lymphedema.</span> </li> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy is a type of radiation therapy that is given at a higher dose over a shorter period of time than standard radiation therapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02958774' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hypofractionated-radiation-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Hypofractionated radiation therapy</a> </li></ul>
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3

NEAREST SITE: 1643 miles
MD Anderson
Houston,TX

VISITS: 1 visit that coincides with surgery

PHASE: NA

NCT ID: NCT04606030

Using a Biobridge Scaffold During Lymphedema Surgery

LymphBridge: Prospective Evaluation of the BioBridge Scaffold as an Adjunct to Lymph Node Transplant for Upper Extremity Lymphedema Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using an experimental device called a Biobridge scaffold during surgery to treat lymphedema.
Who is this for?
People who have completed breast cancer treatment at least three years ago, have no evidence of disease, and have been diagnosed with lymphedema.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT) </li> <li class="seamTextUnorderedListItem">BioBridge Collagen Matrix inserted into your body during surgery </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that may develop as a side effect of some breast cancer therapies. </li> <li class="seamTextUnorderedListItem">Lymphedema happens when there is a blockage in your lymphatic system (a part of your immune system) that stops the lymph fluid from draining well. The fluid buildup causes the abnormal swelling. </li> <li class="seamTextUnorderedListItem">The surgery used in this trial to help with your <span class="highlight">lymphedema</span> is called a vascularized lymph node transfer.</li> <li class="seamTextUnorderedListItem">Your doctor will insert a Biobridge scaffold during your vascularized lymph node transfer. </li> <li class="seamTextUnorderedListItem">The Biobridge scaffold is made of collagen and may help lymph vessels grow around lymph blockages.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04606030' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/conditions-and-diseases/breast-cancer/breast-cancer-lymphedema-after-treatment' target='_blank'>Johns Hopkins Medicine: Breast Cancer, Lymphedema After Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://intermountainhealthcare.org/services/cancer-care/treatments-and-procedures/lymphedema-treatment/our-services/vascularized-lymph-node-transfer/' target='_blank'>Intermountain Healthcare: Vascularized Lymph Node Transfer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fibralignbio.com/biobridge-2/' target='_blank'>Fibralign Corporation Medical Device Information Page: Biobridge</a> </li></ul>
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4

NEAREST SITE: 2054 miles
University of Michigan (Data Collection Only)
Ann Arbor,MI

VISITS: Coincides with surgery and routine care

PHASE: NA

NCT ID: NCT04854005

Use of Upfront Sentinel Lymph Node Biopsy for Stage I-II HR+, HER2-, Node Positive Breast Cancer

Selective Use of ALND in cT1-2N1 HR+/HER2- Breast Cancer Patients With 1 or 2 Positive Sentinel Lymph Nodes Undergoing Upfront Breast Conservation: A Prospective Study Scientific Title

Purpose
To determine if people with stage I-II HR+, HER2-, node positive breast cancer but low nodal burden can undergo sentinel lymph node biopsy (SLNB) instead of axillary lymph node dissection (ALND), which is a more invasive procedure.
Who is this for?
People with stage I or stage II hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-), node positive breast cancer with limited nodal burden suggested by exam and ultrasound before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary ultrasound (AUS)</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sentinel lymph node biopsy (SNLB)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary ultrasound (AUS) is an ultrasound of the armpit area to look for lymph nodes in the armpit that may contain cancer.</li> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND) is a procedure that removes most lymph nodes in the armpit.</li> <li class="seamTextUnorderedListItem">Sentinel lymph node biopsy (SLNB) is a procedure that evaluates the first few lymph nodes in the lymphatic chain in which cancer cells are most likely to have spread.</li> <li class="seamTextUnorderedListItem">ALND is known to be a more invasive procedure with more long-term complications than SLNB, particularly <span class="highlight">lymphedema.</li></span> <li class="seamTextUnorderedListItem">In this trial, HER2 low is defined as IHC 1+ and ISH-.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04854005' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercourse.org/axillary-ultrasound/' target='_blank'>Breast Cancer School: Axillary Ultrasound</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cedars-sinai.org/health-library/diseases-and-conditions/a/axillary-lymph-node-dissection.html#:~:text=Axillary%20lymph%20node%20dissection%20(ALND,to%20remove%20these%20lymph%20nodes.&text=ALND%20happens%20after%20cancer%20cells,side%20of%20th' target='_blank'>Cedars Sinai: Axillary Lymph Node Dissection</a> </li></ul>
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5

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Consent only)
Basking Ridge,NJ

VISITS: 5 visits, over 2 years

PHASE: NA

NCT ID: NCT02743858

Learning Why Some Women Develop Lymphedema After Surgery and Others Do Not

A Prospective Surveillance Program for Assessment and Treatment of Breast Cancer-Related Lymphedema After Axillary Lymph Node Dissection Scientific Title

Purpose
To study why some women develop lymphedema after breast cancer surgery that includes an axillary lymph node dissection (ALND).
Who is this for?
Women recently diagnosed with stage I, stage II or stage III breast cancer. You must be planning to have a breast cancer surgery at Memorial Sloan Kettering Cancer Center that includes the removal of nearby lymph nodes under the arm (ALND)    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Over 2 years, you will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">5 arm measurements</li> <li class="seamTextUnorderedListItem">5 height and weight measurements</li> <li class="seamTextUnorderedListItem">5 quality of life questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Breast tissue taken during surgery will be studied for signs of inflammation, which may increase a woman's risk for <span class="highlight">lymphedema.</i></span></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a painful swelling of the hand, wrist and/or arm that can occur after breast cancer surgery.</li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02743858' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq' target='_blank'>NCI: Lymphedema PDQ</a> </li></ul>
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6

NEAREST SITE: 2691 miles
Massachusetts General Hospital
Boston,MA

VISITS: Coincides with standard follow-up care

PHASE: NA

NCT ID: NCT01521741

Impact of Lymphedema on Quality of Life After Breast Cancer

Prospective Analysis of Symptoms, Functionality and Quality of Life Questionnaires to Evaluate Lymphedema in Patients Following Treatment for Breast Cancer. Scientific Title

Purpose
To determine how the symptoms and functional disability that accompany lymphedema can impact breast cancer survivors' quality of life.
Who is this for?
Women with breast cancer without axillary lymph node malignancy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will complete the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires and arm measurements</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer treatments can result in long-term, painful swelling of the arm and hand, a condition called <span class="highlight">lymphedema.</li></span> <li class="seamTextUnorderedListItem">To be eligible, participants must be planning to have surgery and receive follow-up care for breast cancer at Massachusetts General Hospital.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01521741' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/lymphedema' target='_blank'>BreastCancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq#section/all' target='_blank'>National Cancer Institute: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/lymphedema.html' target='_blank'>American Cancer Society: Lymphedema</a> </li></ul>
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7

NEAREST SITE: 2693 miles
Massachusetts General Hospital
Boston,MA

VISITS: 1 visit every 3 months up to 5 years

PHASE: NA

NCT ID: NCT05142800

Screening Women with Breast Cancer for Edema and Lymphedema During Targeted Therapy

Screening for Edema and Breast Cancer-Related Lymphedema in Patients Undergoing Targeted Therapy for Breast Cancer Scientific Title

Purpose
To study the onset of edema (swelling) and breast cancer-related lymphedema in women with breast cancer.
Who is this for?
Women with stage 0 (DCIS), stage I, stage II, stage III, or stage IV (metastatic) breast cancer who are receiving targeted therapy after surgery at Massachusetts General Hospital Breast Cancer Center.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Informational brochure about <span class="highlight">lymphedema</span> risk</li> <li class="seamTextUnorderedListItem"><span class="highlight">Lymphedema</span> screening program card</li> <li class="seamTextUnorderedListItem">Measurement of arm volume with perometer and SOZO device, every 3 months up to 5 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Edema is swelling of body tissues due to excess fluid.</li> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling that occurs following damage to the lymphatic system, which can happen after breast cancer surgery.</li> <li class="seamTextUnorderedListItem">The perometer uses light sensors to calculate the length and volume of your arms.</li> <li class="seamTextUnorderedListItem">The SOZO device measures the amount of fluid in your arm(s).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05142800' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li></ul>
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