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In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. Use the contact information in our trial listings to call or email the research site for information about a trial's status.

Visit COVID-19 & Cancer Clinical Trials on Metastatic Trial Talk for regularly updated information about clinical trials during the coronavirus pandemic.


Currently viewing trials
(Last updated: September 08, 2020)

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Treatment

BRCA1/2 (inherited)

Chemotherapy

Hormone Therapy

Radiation Oncology

Surgery

Surgery: Reconstruction

Targeted Therapy: All

Targeted Therapy: Anti-HER2 Therapy

Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

Targeted Therapy: Other Targeted Therapy

Vaccines and Immunotherapy

Other Treatment

Non-Treatment

Activities

Complementary and Alternative Medicine

Decision Support

Diagnosing Breast Cancer

Genetics/Family History

Having Children

Lymphedema

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No Travel Required

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Preventing Recurrence

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AKT

ALK

AR

BARD1

BRCA1/2 (tumor)

BRIP1

CD205

CD70

CHEK2 or CHEK1

ESR1

FGFR

HER2/ERBB2

HLA

MET or C-Met

NTRK

PALB2

PIK3CA or PI3K

PTEN

RAD51

RAF (including BRAF)

RAS (KRAS or NRAS)

RB

ROS1

TP53

Click here to view online studies and trials that do not require site visits

1

NEAREST SITE: 2 miles
Zuckerberg San Francisco General Hospital
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT02927249

Aspirin to Prevent Recurrence in Stage II-III, HER2 Negative, Node-Positive Breast Cancer

A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for Node Positive HER2 Negative Breast Cancer: The ABC Trial Scientific Title

Purpose
To study whether taking aspirin daily for five years can reduce the risk of a breast cancer recurrence.
Who is this for?
People who have completed treatment for stage II or stage III, HER2 negative (HER2-) breast cancer. You must also have had cancer cells found in your lymph nodes    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aspirin, by mouth, daily, up to 5 years </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily, up to 5 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aspirin is widely used because of its ability to reduce pain, fever, inflammation, and blood clotting.</li> <li class="seamTextUnorderedListItem">For more information, please email: DFCIABC@PARTNERS.ORG</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02927249' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://jcto.weill.cornell.edu/open_clinical_trials/a011502-aspirin-in-preventing-recurrence-of-cancer-in-patients-with-node-positive-her2-negative-stage-ii-iii-breast-cancer-after-chemotherapy-surgery-andor-radiation-therapy' target='_blank'>Weill Cornell Medicine: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/aspirin-and-secondary-cancer' target='_blank'>Cancer Research UK: Can Aspirin Stop My Cancer Spreading?</a> </li><li class='seamTextUnorderedListItem'><a href='https://blog.dana-farber.org/insight/2019/11/should-i-take-aspirin-to-prevent-cancer/' target='_blank'>Dana-Farber Cancer Institute: Should I Take Aspirin to Prevent Cancer?</a> </li></ul>
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2

NEAREST SITE: 2 miles
Zuckerberg San Francisco General Hospital
San Francisco,CA

VISITS: 3 or 5 visits, over 5 years

PHASE: III

NCT ID: NCT03233191

Digital Tomosynthesis Mammography for Breast Cancer Screening

Tomosynthesis Mammographic Imaging Screening Trial (TMIST) Scientific Title

Purpose
To study whether digital tomosynthesis (3D) mammography or digital (2D) mammography is better at finding early-stage tumors and improving breast cancer survival.
Who is this for?
Women, age 45 to 74, who have never been diagnosed with DCIS or breast cancer. You must not have had a screening mammogram within the last 11 months    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard digital (2D) mammogram</li> <li class="seamTextUnorderedListItem">if you are premenopausal, once a year, for 5 years</li> <li class="seamTextUnorderedListItem">if you are postmenopausal, once every two years, 5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Digital tomosynthesis (3D) mammogram</li> <li class="seamTextUnorderedListItem">if you are premenopausal, once a year, for 5 years</li> <li class="seamTextUnorderedListItem">if you are postmenopausal, once every two years, 5 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Digital tomosynthesis (3D) mammography is approved by the FDA but is not considered the standard of care for breast cancer screening.</li> <li class="seamTextUnorderedListItem">Digital (2D) mammography is the standard of care for breast cancer screening.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03233191' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ecog-acrin.org/tmist' target='_blank'>ECOG-ACRIN Cancer Research Group Trial Information Page: TMIST</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/testing/types/dig_tomosynth' target='_blank'>Breastcancer.org: Digital Tomosynthesis</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/breast_center/treatments_services/breast_cancer_screening/digital_mammography/index.html' target='_blank'>Johns Hopkins Medicine: Digital Mammography</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2017/tmist-breast-cancer-screening' target='_blank'>NCI Cancer Currents Blog: TMIST Trial Aims to Provide Clarity on Breast Cancer Screening Approaches</a> </li></ul>
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3

NEAREST SITE: 2 miles
UCLA Pasadena Health Care Hematology Oncology
Pasadena,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT03701334

Ribociclib With Hormone Therapy For Stage II-III, Hormone Positive, HER2 Negative Breast Cancer

A Phase III Multi-center, Randomized, Open-label Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as an Adjuvant Treatment in Patients With Hormone Receptor-positive, HER2-negartive Early Breast Cancer (New Adjuvant TriAl With Ribociclib [LEE011]: NATALEE) Scientific Title

Purpose
To compare the effectiveness and side effects of ribociclib (Kisqali®) and hormonal therapy to hormonal therapy alone.
Who is this for?
People with stage II or stage III, hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ribociclib (Kisqali®), by mouth, daily, 3 weeks on and 1 week off</li> <li class="seamTextUnorderedListItem">Hormonal therapy, by mouth, daily (determined by your physician)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormonal therapy, by mouth, daily (determined by your physician)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Kisqali®) is a type of targeted therapy called a cyclin-dependent kinase (CDK) inhibitor. </li> <li class="seamTextUnorderedListItem">It blocks two enzymes, CDK4 and CDK6, that help cancer cells grow. </li> <li class="seamTextUnorderedListItem">It is approved for use in combination with an aromatase inhibitor to treat postmenopausal women with advanced or metastatic hormone positive, HER2 negative breast cancer. </li> <li class="seamTextUnorderedListItem">Its use in early-stage breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03701334' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.us.kisqali.com/metastatic-breast-cancer/about-kisqali/how-to-take-kisqali/?site=KIS-1224412GK100239&source=01030&gclid=Cj0KCQjwyPbzBRDsARIsAFh15JYgYdpo-b7mOLbbivjBy7RDVkyxmjPTzI6_rgA9hEZPiCp7MxxVq1saAq7nEALw_wcB&gclsrc=aw.ds' target='_blank'>Drug Company Information Page: Kisqali® (Ribociclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/CDK46inhibitorsfortreatmentofmetastaticbreastcancer.html' target='_blank'>Susan G. Komen: CDK 4/6 Inhibitors for the Treatment of Metastatic Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/publications/oncology-live/2019/vol-20-no-1/cdk46-inhibitors-explored-in-adjuvant-breast-cancer-setting' target='_blank'>OncLive: CDK 4/6 Inhibitors Explored in Adjuvant Breast Cancer Setting</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.TPS597' target='_blank'>ASCO Abstract: NATALEE Phase III Study of Ribociclib and Hormone Therapy</a> </li></ul>
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4

NEAREST SITE: 3 miles
UCSF - Helen Diller Family Comprehensive Cancer Center
San Francisco,CA

VISITS: Weekly

PHASE: I

NCT ID: NCT02684032

Anti-Estrogen Therapy, Palbociclib, and Gedatolisib for Metastatic ER+, HER2- Breast Cancer

Phase 1b Study To Assess The Safety, Tolerability, And Clinical Activity Of Gedatolisib In Combination With Palbociclib And Either Letrozole Or Fulvestrant In Women With Metastatic Or Locally Advanced/Recurrent Breast Cancer (MBC) Scientific Title

Purpose
To study the anti-cancer activity of using an anti-estrogen therapy (letrozole or fulvestrant) in combination with the CDK4/6 inhibitor palbociclib and the mTOR inhibitor gedatolisib. given in combination with either Femara or Faslodex.
Who is this for?
Women with metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer. You must not have already received an mTOR inhibitor, PI3K inhibitor, or more than one chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gedatolisib, by IV, weekly, ongoing</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gedatolisib, by IV, weekly, ongoing</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 3 times the first month, then once a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is commonly used in combination with either letrozole (Femara®) or fulvestrant (Faslodex®) for metastatic, hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer.</li> <li class="seamTextUnorderedListItem">Gedatolisib is an experimental targeted therapy, this means it is only available in clinical trials. </li> <li class="seamTextUnorderedListItem">Gedatolisib works by blocking two proteins, PI3K and mTOR, that help tumors grow.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02684032' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com/?src_code=IBRW10028851' target='_blank'>Pfizer Oncology Drug Information Page: Ibrance® (Palbociclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Gedatolisib' target='_blank'>Wikipedia: Gedatolisib</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/targeted_therapies/ibrance' target='_blank'>Breastcancer.org: Palbociclib (Ibrance®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/AromataseInhibitors.html' target='_blank'>Susan G. Komen: Aromatase Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/4_Supplement/OT2-07-06' target='_blank'>AACR Abstract: Study of Gedatolisib with Ibrance</a> </li></ul>
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5

NEAREST SITE: 3 miles
Sutter Cancer Research Consortium
San Francisco,CA

VISITS: Coincides with targeted therapy

PHASE: II

NCT ID: NCT02693535

Choosing Targeted Therapy Based on a Tumor's Genetic Makeup for Advanced Breast Cancer (TAPUR)

A Basket Study: Targeted Agent and Profiling Utilization Registry (TAPUR) Study Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using a tumor's genetic alterations to select an FDA-approved targeted therapy for treatment.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer for whom there is no currently available therapy. You must have results from a genomic or immunohistochemistry test approved by TAPUR.    Full eligibility criteria
Contact research site
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will receive an FDA-approved targeted therapy that is chosen based on the tumor's genetic makeup.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The targeted therapy you receive will be selected based on your tumor's specific genetic profile.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer. </li> <li class="seamTextUnorderedListItem">Your treatment may include one or more of the following: Abemaciclib, Afatinib, Crizotinib, Nivolumab, Ipilimumab, Olaparib, Palbociclib, Pembrolizumab, Regorafenib, Sunitinib, Talazoparib, Temsirolimus, Trastuzumab, Pertuzumab, Vemurafenib, Cobimetinib</li> <li class="seamTextUnorderedListItem">Targets or mutations: ALK, ATM, BRAF, BRAF V600E/D/K/R, BRCA1/2, CDK4, CDK6, CDKN2A, CSF1R, HER2 (ERBB2), high mutational load and others, KIT, MET, MSI-H, mTOR, NRG1, PALB2, PDGFR, POLD1, POLE, RAF-1, RET, ROS1, TSC, VEGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02693535' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.tapur.org/' target='_blank'>ASCO Study Website: TAPUR</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/conference-coverage/asco-2016/dr-edward-kim-on-ascos-tapur-trial' target='_blank'>OncLive: About TAPUR (video)</a> </li></ul>
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6

NEAREST SITE: 3 miles
Kaiser Permanente-San Francisco
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02465060

NCI-MATCH: Using Genomic Test Results To Choose A Targeted Therapy For Metastatic Breast Cancer

A Basket study: Molecular Analysis for Therapy Choice (MATCH) Scientific Title

Purpose
To study the anti-cancer activity of receiving a targeting therapy that was chosen based on the results of your tumor's genomic testing.
Who is this for?
People with metastatic (stage IV) breast cancer whose cancer progressed during or after standard of care treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Your tumor sample will be tested for genetic mutations (genomic testing)</li> <li class="seamTextUnorderedListItem">You will be assigned to 1 of 24 treatment groups based on the results of your tumor's genomic test</li> <li class="seamTextUnorderedListItem">End-of-treatment biopsy and collection of blood samples for research purposes (optional)</li> <li class="seamTextUnorderedListItem">This process may be repeated if your disease progresses</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Genomic testing looks at genetic mutations within your tumor.</li> <li class="seamTextUnorderedListItem">The drug you receive will be determined by the results of your tumor's genomic test. </li> <li class="seamTextUnorderedListItem">Your may receive one or more of the following drugs: Adavosertib, Afatinib, Binimetinib, Capivasertib, Copanlisib, Crizotinib, Dabrafenib, Dasatinib, Defactinib, Erdafitinib, FGFR Inhibitor AZD4547, Larotrectinib, Nivolumab, Osimertinib, Palbociclib (CDK inhibitor), Pertuzumab (anti-HER2), PI3K-beta Inhibitor GSK2636771, Sapanisertib, Sunitinib Malate, Taselisib, Trametinib, Trastuzumab Emtansine/Kadcyla (antibody-drug conjugate (ADC)), Vismodegib</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with other types of cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: ABL, ALK, BRAF, CDK4, CDK6, CSF-1R, EGFR, EGFR T790M, FGFR, FLT3, HER2 (ERBB2), KIT, MET, MEK, mTOR, NTRK fusions, PD-1, PDGFR, PI3K, PTCH1, PTEN loss, RET, ROS1, SMO, TRK, VEGFR, WEE1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02465060' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/about-cancer/treatment/clinical-trials/nci-supported/nci-match' target='_blank'>National Cancer Institute Study Website: NCI-Match</a> </li><li class='seamTextUnorderedListItem'><a href='https://ecog-acrin.org/nci-match-eay131' target='_blank'>ECOG-ACRIN Cancer Research Group: NCI-Match</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/diagnosis/genomic_assays' target='_blank'>Breastcancer.org: Tumor Genomic Assay Testing</a> </li></ul>
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7

NEAREST SITE: 3 miles
UCSF Mount Zion Medical Ctr
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02568267

Basket Study of Entrectinib in Tumors With a NTRK1/2/3, ROS1, or ALK Mutation

An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements Scientific Title

Purpose
To study the effects (good and bad) of entrectinib (Rozlytrek®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer. Your tumor must test positive for or express one of the following: NTRK 1/2/3, ROS 1, or ALK mutation.    Full eligibility criteria
Contact research site
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Contact Research Sites

  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Entrectinib (Rozlytrek®), by mouth, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Basket studies enroll people based on the kind of mutations found in their tumors. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer whose tumors test positive for certain mutations.</li> <li class="seamTextUnorderedListItem">Targets or mutations: NTRK 1/2/3, ROS1, and ALK</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02568267' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.rozlytrek.com/?c=ent-16b05ae9ce6&gclid=Cj0KCQjw-_j1BRDkARIsAJcfmTHfl5vGlhgj7U1G_eLElm-4GOU_P5TcEhf6NBVhkZbfVZ07uc4f9UwaAnOiEALw_wcB&gclsrc=aw.ds' target='_blank'>Genentech Information Page: Rozlytrek® (Entrectinib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Entrectinib' target='_blank'>Wikipedia: Entrectinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2019/fda-entrectinib-ntrk-fusion' target='_blank'>NCI Cancer Currents Blog: FDA Approves Entrectinib Based on Tumor Genetics Rather Than Cancer Type</a> </li></ul>
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8

NEAREST SITE: 3 miles
Kaiser Permanente-San Francisco
San Francisco,CA

VISITS: Weekly visits for 5 months

PHASE: III

NCT ID: NCT02488967

AC Chemo Followed by Taxol with or without Paraplatin for Triple-Negative Breast Cancer

Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast CancerDoxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer Scientific Title

Purpose
To compare the effects (good and bad) of AC followed by Taxol followed by Paraplatin to AC followed by Taxol.
Who is this for?
People with stage I, stage II, or stage III triple negative (ER-, PR-, HER2-) breast cancer. You must have had breast cancer surgery with clear margins (cancer free area around where tumor was removed).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AC (Adriamycin® and Cytoxan®) by IV once every 2 weeks for 2 months</li> <li class="seamTextUnorderedListItem">followed by paclitaxel (Taxol®) by IV weekly for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AC (Adriamycin® and Cytoxan®) by IV once every 2 weeks for 2 months</li> <li class="seamTextUnorderedListItem">followed by paclitaxel (Taxol®) by IV weekly for 3 months</li> <li class="seamTextUnorderedListItem">followed by carboplatin (Paraplatin®) by IV every 3 weeks for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doxorubicin (Adriamycin®) and cyclophosphamide (Cytoxan®)--known as AC--and paclitaxel (Taxol®) are chemotherapy drugs routinely used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) is a platinum-based chemotherapy drug that studies suggest is effective for triple-negative breast cancer.</li> <li class="seamTextUnorderedListItem">Patients who did not have clean margins will need to have radiation therapy to the chest wall before entering the trial.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02488967' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://triplesteptowardthecure.org/' target='_blank'>Triple Step Toward the Cure</a> </li><li class='seamTextUnorderedListItem'><a href='http://www2.mdanderson.org/cancerwise/2015/04/finding-hope-after-triple-negative-breast-cancer.html' target='_blank'>MD Anderson: Hope After Triple-Negative Breast Cancer</a> </li></ul>
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9

NEAREST SITE: 3 miles
University of California San Francisco (UCSF)
San Francisco,CA

VISITS: Weekly visits for 4 months

PHASE: II

NCT ID: NCT01042379

Personalized Treatment Before Surgery For Stage II-III Breast Cancer: The I-SPY 2 Trial

I-SPY 2 Trial (Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging And moLecular Analysis 2) Scientific Title

Purpose
To compare the safety and anti-cancer activity of giving the standard of care to giving the standard of care plus an experimental drug that was chosen based on your tumor's biomarkers.
Who is this for?
People with stage II or stage III breast cancer who have not yet started treatment and whose cancer is considered high-risk for recurrence.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups, and receive the following before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care therapy</li> <li class="seamTextUnorderedListItem">At least one experimental therapy that is chosen based on your tumor's biomarkers</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">4 MRIs</li> <li class="seamTextUnorderedListItem">2 biopsies</li> <li class="seamTextUnorderedListItem">Blood draws</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This clinical trial has an <q>adaptive design.</q> This means that experimental drugs will be added during the trial, and experimental drugs that are not more effective than standard of care therapy will be removed. </li> <li class="seamTextUnorderedListItem">At least 80% of people who enroll will receive an experimental drug. </li> <li class="seamTextUnorderedListItem">This trial will use several types of experimental drugs: immunotherapies, anti-hormone therapies, PARP inhibitors, CDK 4/6 inhibitors, and others. </li> <li class="seamTextUnorderedListItem">All drugs will be given prior to surgery (neoadjuvant therapy), this allows researchers to see how your tumor is responding to the drugs. </li> <li class="seamTextUnorderedListItem">The information that researchers gain from studying your tumor's response will be used to help decide which drugs should be given to people who join the trial after you.</li> <li class="seamTextUnorderedListItem">MammaPrint is a genomic test (analyzes your tumor) that gives two types of recurrence scores, low risk or high risk.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01042379' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://ispy2.org/' target='_blank'>Quantum Leap Healthcare Collaborative Study Website: I-SPY 2</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/MammaPrint' target='_blank'>Wikipedia: MammaPrint</a> </li><li class='seamTextUnorderedListItem'><a href='https://pubmed.ncbi.nlm.nih.gov/32701140/' target='_blank'>Journal Article: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial</a> </li></ul>
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10

NEAREST SITE: 3 miles
University of California, San Francisco Medical Center
San Francisco,CA

VISITS: 1 visit every 4 weeks, ongoing

PHASE: II

NCT ID: NCT01494662

Neratinib for HER2-Positive Brain Metastases

A Phase II Trial of HKI-272 (Neratinib) for Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer and Brain Metastases Scientific Title

Purpose
To determine how well neratinib works in treating breast cancer that has spread to the brain, as well as the effect that it has on cognitive functioning.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the brain.    Full eligibility criteria
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  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib by mouth daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain metastases are difficult to treat because many drugs are unable to cross the blood-brain barrier, which means they cannot enter the brain from the bloodstream. </li> <li class="seamTextUnorderedListItem">The experimental drug Neratinib (HKI-272) is a tyrosine kinase inhibitor. </li> <li class="seamTextUnorderedListItem">It works by blocking the HER2 and EGFR receptors, both of which are involved in cancer cell growth. </li> <li class="seamTextUnorderedListItem">Neratinib is a much smaller molecule than Herceptin® (the drug widely used to treat HER2+ tumors), and it is able to cross the blood-brain barrier. </li> <li class="seamTextUnorderedListItem">The goal of this trial is to determine how well neratinib works in treating breast cancer that has spread to the brain, as well as the effect that it has on cognitive functioning.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01494662' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.sciencedaily.com/releases/2009/05/090528203821.htm' target='_blank'>Science Daily Article</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.curetoday.com/index.cfm/fuseaction/news.showNewsArticle/id/5/news_id/2357' target='_blank'>Cure Magazine Article</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/search.jsp?terms=neratinib' target='_blank'>BreastCancer.org: Neratinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://externalmediasite.partners.org/Mediasite/Play/dbc4bfbf0f6a46208443613881b188e41d' target='_blank'>Dana-Farber Cancer Institute: Patient-friendly informational video about this trial</a> </li></ul>
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11

NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT01570998

Targeted Intraoperative Radiotherapy (TARGIT) Registry Trial

Targeted Intraoperative Radiotherapy United States (TARGIT-US) Phase IV Registry Trial: A Registry Trial of Targeted Intraoperative Radiation Therapy Following Breast-conserving Surgery Scientific Title

Purpose
To study the effects (good and bad) of targeted intraoperative radiotherapy.
Who is this for?
Women 45 and older, with stage I or stage II estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who will have a lumpectomy (breast conserving surgery) and are considered low risk for a local recurrence.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy as a single dose after breast conserving surgery (lumpectomy)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Participants may receive whole breast radiation, if indicated.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation is used to kill any breast cancer cells that may not have been removed during surgery.</li> <li class="seamTextUnorderedListItem">Targeted intraoperative radiotherapy is delivered during surgery immediately after the tumor has been removed. This allows the radiation to accurately target the tissue surrounding the tumor, where the risk of recurrence is highest.</li> <li class="seamTextUnorderedListItem">It takes about 20-35 minutes to provide intraoperative radiotherapy.</li> <li class="seamTextUnorderedListItem">The Targeted Intraoperative Radiotherapy Trial (TARGIT), will follow women who receive this type of radiation therapy for five years, allowing researchers to study its effectiveness and side effects.</li> <li class="seamTextUnorderedListItem">If indicated, you will also receive whole breast radiation.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01570998' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation/types/intraoperative' target='_blank'>BreastCancer.org: Intraoperative Radiation</a> </li><li class='seamTextUnorderedListItem'><a href='https://scholar.google.com/scholar?q=intraoperative+radiation+therapy+breast+cancer&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ei=V-NpUMOGOObmiwKC2IHQDg&ved=0CCkQgQMwAA' target='_blank'>Google Scholar: Intraoperative Radiation</a> </li></ul>
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12

NEAREST SITE: 3 miles
California Pacific Medical Center-Pacific Campus
San Francisco,CA

VISITS: After surgery, visits 5 days a week, 5-6 weeks

PHASE: III

NCT ID: NCT01901094

Lymph Node Dissection & Radiation or Radiation Alone In Women Who Still Had Cancer Cells in Their Lymph Nodes After Neoadjuvant Therapy

A Randomized Phase III Trial Evaluating the Role of Axillary Lymph Node Dissection in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy Scientific Title

Purpose
To compare the anti-cancer activity of axillary lymph node dissection (surgery to remove your lymph nodes) followed by radiation therapy to radiation therapy alone.
Who is this for?
People with stage I, stage II, or stage III breast cancer who still had cancer cells in their lymph nodes after they received neoadjuvant treatment.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery to identify sentinel lymph node(s)</li> <li class="seamTextUnorderedListItem">Axillary Lymph Node Dissection (ALND)</li> <li class="seamTextUnorderedListItem">Radiation therapy, 5 days a week, for 5-6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery to identify sentinel lymph node(s)</li> <li class="seamTextUnorderedListItem">Radiation therapy, 5 days a week, over 5-6 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to kill tumor cells that remain after surgery.</li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01901094' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/surgery/lymph_node_removal/axillary_dissection' target='_blank'>Breastcancer.org: Axillary Lymph Node Dissection</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/surgery-for-breast-cancer/lymph-node-surgery-for-breast-cancer.html' target='_blank'>American Cancer Society: Lymph Node Surgery for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/issues/march-10-2019/long-term-study-finds-axillary-radiotherapy-safe-and-effective-after-positive-sentinel-node-biopsy/' target='_blank'>ASCO Post: Long-Term Study Finds Axillary Radiotherapy Safe and Effective After Positive Sentinel Node Biopsy</a> </li></ul>
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13

NEAREST SITE: 3 miles
University of California at San Francisco
San Francisco,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I

NCT ID: NCT01969643

SGN-LIV1A for Metastatic HER2 Negative Breast Cancer

A Phase 1, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of SGN-LIV1A in Patients With LIV-1-Positive Metastatic Breast Cancer Scientific Title

Purpose
To determine the safety, highest tolerable dose and anti-tumor activity of SGN-LIV1A.
Who is this for?
Women with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or HER2 negative (HER2-), hormone receptor positive (ER+ and/or PR+) breast cancer that can no longer be treated with a hormone therapy.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SGN-LIV1A, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Antibody-drug conjugate (ADC) is a cancer therapy that combines an antibody that targets cancer cells with a drug that can kill cancer cells. </li> <li class="seamTextUnorderedListItem">Because the antibody only targets cancer cells, the drug does not kill normal cells, making it less likely to cause side effects. </li> <li class="seamTextUnorderedListItem">SGN-LIV1A is an ADC that targets LIV-1 (SLC39A6), a protein that is expressed by most breast cancer cells, and delivers a cancer drug called monomethyl auristatin E.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01969643' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.seattlegenetics.com/pipeline/sgn-liv1a' target='_blank'>Seattle Genetics Drug Information Page: SGN-LIV1A</a> </li></ul>
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14

NEAREST SITE: 3 miles
Univ of California San Francisco
San Francisco,CA

VISITS: Monthly visits

PHASE: III

NCT ID: NCT02107703

LY2835219 Plus Faslodex For Advanced ER/PR Positive HER2 Negative Breast Cancer

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Fulvestrant With or Without LY2835219, a CDK4/6 Inhibitor, for Women With Hormone Receptor Positive, HER2 Negative Locally Advanced or Metastatic Breast Cancer Scientific Title

Purpose
To compare the effectiveness of LY2835219 (abemaciclib) and Faslodex with Faslodex alone.
Who is this for?
Postmenopausal women with advanced (some stage III) or metastatic (stage IV) breast cancer that is estrogen receptor positive and HER2 negative.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY2835219 (abemaciclib) by mouth, daily </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) by injection, once a month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo by mouth, daily </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) by injection, once a month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers are studying new treatments for patients with tumors that are ER+ and/or PR+. (These tumors are also called hormone-receptor positive (HR+). </li> <li class="seamTextUnorderedListItem">LY2835219 (abemaciclib) is a new drug that keeps cancer cells from reproducing by blocking two kinases called CDK 4 and 6. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a hormone therapy that is widely used to treat postmenopausal women with HR+ tumors that have stopped responding to other hormonal therapies. </li> <li class="seamTextUnorderedListItem">This study will compare the effectiveness of LY2835219 (abemaciclib) and Faslodex with Faslodex alone in postmenopausal patients with advanced HR+, HER2-negative breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02107703' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://investor.lilly.com/releasedetail.cfm?releaseid=848054' target='_blank'>Lilly: Abemaciclib</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/hormonal/erds/faslodex' target='_blank'>BreastCancer.org: Faslodex</a> </li></ul>
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15

NEAREST SITE: 3 miles
California Pacific Medical Center-Pacific Campus
San Francisco,CA

VISITS: Visits every 3 weeks for 3 months

PHASE: III

NCT ID: NCT02445391

Chemo After Neoadjuvant Chemo and Surgery for Basal-Like Triple-Negative Breast Cancer

A Randomized Phase III Post-Operative Trial of Platinum Based Chemotherapy vs. Observation in Patients With Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Chemotherapy (EA1131) Scientific Title

Purpose
To see whether giving a chemotherapy drug after surgery reduces the risk of recurrence.
Who is this for?
People with triple negative (ER-, PR-, HER2-) breast cancer who had neoadjuvant therapy that did not make their tumor disappear.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cisplatin (Platinol®) or Carboplatin (Paraplatin®) by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: No intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Observation</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neoadjuvant chemotherapy (treatment given before surgery) is used to shrink the tumor. </li> <li class="seamTextUnorderedListItem">Sometimes the tumor will disappear completely. In other instances, the tumor can be seen during surgery. </li> <li class="seamTextUnorderedListItem">Cisplatin (Platinol®) and carboplatin (Paraplatin®) are platinum-based chemotherapy drugs that laboratory studies suggest may be effective against basal-like triple-negative breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02445391' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.medscape.com/viewarticle/736911_4' target='_blank'>MedScape: Basal-like breast cancers</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.ca/en/cancer-information/cancer-type/breast/breast-cancer/cancerous-tumours/triple-negative-breast-cancer/?region=on' target='_blank'>Canadian Cancer Society: Triple-negative and basal-like breast cancers</a> </li></ul>
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16

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco,CA

VISITS: 1-2 visits over 3 weeks

PHASE: II

NCT ID: NCT02206984

Hormone Therapy Before Surgery for Invasive Lobular Breast Cancer

A Trial of Endocrine Response in Women With Invasive Lobular Breast Cancer Scientific Title

Purpose
To look at which anti-estrogen treatment is best to use before surgery.
Who is this for?
Postmenopausal women diagnosed with invasive lobular breast cancer who had not yet had surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups and receive the following over 21 days before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Anastrozole (Arimidex®), by mouth, daily </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), injected into a muscle (like a shot), on days 1 and 14</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Each patient in the study will receive one of the three anti-estrogen drugs the researchers are studying. </li> <li class="seamTextUnorderedListItem">These three drugs are tamoxifen (Nolvadex®), anastrozole (Arimidex®), and fulvestrant (Faslodex®).</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02206984' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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17

NEAREST SITE: 3 miles
University of California San Francisco
San Francisco,CA

VISITS: Online surveys

PHASE: NA

NCT ID: NCT02620852

WISDOM Study: Women Informed to Screen Depending on Measures of Risk

Enabling a Paradigm Shift: A Preference-Tolerant RCT of Personalized vs. Annual Screening for Breast Cancer Scientific Title

Purpose
To learn if risk-based breast screening is as safe and effective as annual mammogram screening for reducing risk and detecting breast cancer.
Who is this for?
Women between the ages of 40 and 70 who have never been diagnosed with breast cancer or ductal carcinoma in situ (DCIS).    Full eligibility criteria
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  • What's involved?
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  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups, or you can choose your study group. </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Personalized, Risk-Based Screening</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Screening recommendations based on comprehensive, personal risk assessment</li> <li class="seamTextUnorderedListItem">Saliva sample genetic test</li> <li class="seamTextUnorderedListItem">Online, annual health questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard Annual Screening</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Screening recommendation for annual mammograms</li> <li class="seamTextUnorderedListItem">Online, annual health questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Personalized risk-based screening will take multiple risk factors into consideration, including genetic markers, to determine how often you should have a mammogram.</li> <li class="seamTextUnorderedListItem">This study will help researchers learn if risk-based screening, which helps women learn more about their personal breast cancer risk, is less stressful and as successful at detecting breast cancer as annual screening. </li> <li class="seamTextUnorderedListItem">This study is available in English and Spanish.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02620852' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.thewisdomstudy.org/' target='_blank'>WISDOM: Study Information Page</a> </li></ul>
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18

NEAREST SITE: 3 miles
UCSF Medical Center-Mount Zion
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT02750826

Weight Loss Program to Prevent Recurrence in Women with HER2-, Stage II-III Breast Cancer

Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women With Early Breast Cancer (BWEL Study) Scientific Title

Purpose
To see if women who take part in a weight loss program after being diagnosed with breast cancer are less likely to have their cancer come back than those who do not take part in the weight loss program.
Who is this for?
Women with stage I or stage II HER2 negative breast cancer. You must also be overweight or obese.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and receive the following over 2 years: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Health Education Program</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General information about healthy living and breast cancer news, over 2 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Health Education Program and Weight Loss Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General information about healthy living and breast cancer news, over 2 years</li> <li class="seamTextUnorderedListItem">Telephone calls with trained coaches, about 2 calls per month for 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">If you are overweight or obese at the time of your breast cancer diagnosis, you have a greater risk of having your cancer come back (recur) than do women who are not overweight or obese.</li> <li class="seamTextUnorderedListItem">To be eligible for this study, you must be overweight or obese (BMI ò27)</li> <li class="seamTextUnorderedListItem">This study will help to see whether weight loss programs should be a part of breast cancer treatment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02750826' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.dana-farber.org/Newsroom/News-Releases/dana-farber-study-testing-the-impact-of-weight-loss-breast-cancer-recurrence.aspx' target='_blank'>Dana Farber News Release</a> </li><li class='seamTextUnorderedListItem'><a href='http://well.blogs.nytimes.com/2016/06/27/putting-breast-cancer-on-a-diet/?rref=collection%2Fsectioncollection%2Fhealth&amp;action=click&amp;contentCollection=health&amp;region=rank&amp;module=package&amp;version=highlights&amp;contentPlacement=7&amp;pgtyp' target='_blank'>New York Times article</a> </li></ul>
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19

NEAREST SITE: 3 miles
Kaiser Permanente-San Francisco
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT02822573

Aricept to Improve Memory Loss in Survivors Who Had Chemotherapy

A Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil in Chemotherapy Exposed Breast Cancer Survivors With Cognitive Impairment Scientific Title

Purpose
To see whether a drug used to treat memory problems helps breast cancer survivors.
Who is this for?
Women with breast cancer who completed treatment with chemotherapy between 1 and 5 years ago. You must be experiencing memory problems.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 to 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Memory questionnaires</li> <li class="seamTextUnorderedListItem">Donepezil (Aricept®), by mouth, daily, for 6 months</li> <li class="seamTextUnorderedListItem">followed by 3 months of no treatment</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Placebo</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Memory questionnaires</li> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily, for 6 months</li> <li class="seamTextUnorderedListItem">followed by 3 months of no treatment</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The study will compare the safety and effects of the drug, donepezil (Aricept®), to a placebo. </li> <li class="seamTextUnorderedListItem">The focus will be on the effect the drug has on memory skills.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02822573' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a697032.html' target='_blank'>MedlinePlus: Donepezil</a> </li></ul>
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20

NEAREST SITE: 3 miles
Kaiser Permanente-San Francisco
San Francisco,CA

VISITS: 1 visit every 2 weeks, ongoing

PHASE: II

NCT ID: NCT02834013

Opdivo & Yervoy for Patients with Metaplastic Breast Cancer

DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Scientific Title

Purpose
To study the safety and effects (good and bad) of using two types of immunotherapy drugs.
Who is this for?
People with metaplastic breast cancer and have already tried at least one other treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, once every 2 weeks</li> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®), by IV, once every 6 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metaplastic breast cancer is a rare form of breast cancer; it makes up fewer than 1% of all breast cancer diagnoses. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other rare cancers. </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®) is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">Ipilimumab (Yerovy®) is a type of immunotherapy called a CTLA-4 inhibitor. </li> <li class="seamTextUnorderedListItem">Opdivo and Yervoy are an approved combination for treating melanoma. </li> <li class="seamTextUnorderedListItem">Neither drug is approved to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02834013' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.metaplasticbc.com' target='_blank'>Metaplastic Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ipilimumab' target='_blank'>NCI drug dictionary: Ipilimumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/nivolumab' target='_blank'>NCI drug dictionary: Nivolumab</a> </li></ul>
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21

NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: Number of visits unavailable, over 4 months

PHASE: NA

NCT ID: NCT02872025

Pembrolizumab Before Surgery for Women With High-Risk DCIS

Testing the Ability of Pembrolizumab to Alter the Tumor Immune MicroEnvironment (TIME) of High Risk DCIS Scientific Title

Purpose
To study the effects (good and bad) of the immunotherapy pembroluzuimab on DCIS and the tissue surrounding DCIS.
Who is this for?
Women with high-risk DCIS planning to have surgery (mastectomy or lumpectomy).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI, at diagnosis and right before surgery</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by injection directly into the DCIS, 4 times, with 2 to 4 weeks between each injection</li> <li class="seamTextUnorderedListItem">Surgery (lumpectomy or mastectomy), 1 to 5 weeks after your last injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI, at diagnosis and right before surgery</li> <li class="seamTextUnorderedListItem">Tissue collection (biopsy of DCIS)</li> <li class="seamTextUnorderedListItem">Surgery (lumpectomy or mastectomy), within 4 months of diagnosis</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking PD-1. </li> <li class="seamTextUnorderedListItem">It is usually given by IV, but for this study it will be injected directly into the DCIS. </li> <li class="seamTextUnorderedListItem">Giving pembrolizumab (Keytruda®) before surgery allows researchers to study the effects it has on DCIS and the microenvironment (the tissue surrounding the DCIS).</li> <li class="seamTextUnorderedListItem">For this trial, high-risk DCIS means you meet at least 2 of the following: you are younger than 45, the DCIS is palpable (able to be felt by touch), larger than 5 cm, grade II-III, HER2 positive (HER2+), or hormone receptor negative (ER- and PR-).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02872025' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/types/dcis/diagnosis' target='_blank'>Breastcancer.org: Diagnosis of DCIS</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/RecommendedTreatmentsforDuctalCarcinomaInSitu.html' target='_blank'>Susan G. Komen: Treatment for DCIS</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.ucsf.edu/trial/NCT02872025' target='_blank'>University of California San Francisco: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.bcrf.org/researchers/laura-j-esserman' target='_blank'>BCRF: Laura J. Esserman (Study Researcher)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=Cj0KCQjw6sHzBRCbARIsAF8FMpU1aXb3OCAoZH-Kz-lr_9qfn5S-yKDUnZ6zjvh8GAJBRQ5kuy7Ih0caAlUVE' target='_blank'>Merck Oncology Drug Information Page: Keytruda® (Pembrolizumab)</a> </li></ul>
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22

NEAREST SITE: 3 miles
UCSF
San Francisco,CA

VISITS: Coincides with standard of care

PHASE: III

NCT ID: NCT02947685

Anti-HER2 Targeted Therapy, Hormone Therapy, and Palbociclib for Metastatic HR+, HER2+ Breast Cancer

A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Endocrine Therapy After Induction Treatment for Hormone Receptor Positive (HR+)/HER2-Positive Metastatic Breast Cancer (PATINA) Scientific Title

Purpose
To compare the safety and effects (good and bad) of giving a CDK4/6 inhibitor with the standard of care therapies to the standard of care therapies alone.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) hormone receptor positive (ER+ and/or PR+), HER2 positive (HER2+) breast cancer. You must have already had at least 4 but no more than 8 cycles of a HER2 targeted therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily</li> <li class="seamTextUnorderedListItem">standard anti-HER2 therapy and hormone therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">standard anti-HER2 therapy and hormone therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a type of targeted therapy called a CDK4/6 inhibitor. It is approved for treating metastatic hormone positive, HER2 negative breast cancer. </li> <li class="seamTextUnorderedListItem">The standard of care for metastatic hormone positive, HER2 negative breast cancer is a combination of a HER2-targeted therapy and an anti-estrogen drug.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02947685' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Palbociclib' target='_blank'>Wikipedia: Palbociclib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com' target='_blank'>Pfizer Oncology Drug Information Page: Ibrance</a> </li></ul>
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23

NEAREST SITE: 3 miles
Kaiser Permanente-San Francisco
San Francisco,CA

VISITS: 1 visit every 3 weeks, for 1 year

PHASE: III

NCT ID: NCT02954874

Keytruda After Neoadjuvant Chemo & Surgery for Stage I-III Triple-Negative Breast Cancer

A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer With 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy Scientific Title

Purpose
To study the effects (good and bad) of giving pembrolizumab (Keytruda®) after chemotherapy and surgery.
Who is this for?
People with stage I, stage II, or stage III triple negative (ER-,PR-,HER2-) breast cancer. You must still have had part of the tumor in your breast and/or been told cancer cells were found in your lymph nodes after you received neoadjuvant (before surgery) chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Observation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No treatment, but monitored during the first year</li> <li class="seamTextUnorderedListItem">Examined every 3 months for 1 year, every 6 months for 4 years, and annually for 5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Keytruda</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, over 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Follow up</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor, it gets the immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">It is approved to treat many types of cancers, including some types of breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02954874' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda® (Pembrolizumab)</a> </li></ul>
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24

NEAREST SITE: 3 miles
UCSF ( Site 0015)
San Francisco,CA

VISITS: Weekly visits for 6 weeks, then 1 visit every 3 weeks, for up to 2 years

PHASE: I

NCT ID: NCT03010176

MK-1454 and Keytruda for Patients With Advanced Breast Cancer

Phase 1 Open Label, Multicenter Study of MK-1454 Administered by Intratumoral Injection as Monotherapy and in Combination With Pembrolizumab for Patients With Advanced/Metastatic Solid Tumors or Lymphomas Scientific Title

Purpose
To determine the best dose and safety of a new immunotherapy drug, MK-1454.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer who have a tumor that has not responded to, or has stopped responding to, other treatments.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MK-1454, by IV, once a week for 6 weeks, then once every 3 weeks for 2 years </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks for 2 years </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MK-1454 is an immunotherapy drug that earlier studies suggest may make tumors more likely to respond to pembrolizumab (Keytruda®). </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor. It gets the immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">Keytruda is approved to treat certain types of cancer, but not breast cancer. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03010176' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://lymphomanewstoday.com/2018/11/05/mk-1454-keytruda-combo-shows-promise-interim-phase-1-data-shows/' target='_blank'>Lymphoma Today: MK-1454/Keytruda Combination Shows Promise in Solid Tumor and Lymphoma Patients</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biopharmadive.com/news/esmo-2018-bavencio-pfizer-rcc-merck-sting-novartis-alpelisib/540263/' target='_blank'>BioPharmadive: ESMO 2018</a> </li></ul>
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25

NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: Visits every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03056755

Targeted Therapy Alpelisib and Anti-Estrogen Therapy for Advanced HR+, HER2- Breast Cancer with a PIK3CA Mutation

A Phase II, Multicenter, Open-label, Two-cohort, Non-comparative Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole in Patients With PIK3CA Mutant, Hormone Receptor (HR) Positive, HER2-negative Advanced Breast Cancer (aBC), Who Have Progressed on or After CDK 4/6 Inhibitor Treatment Scientific Title

Purpose
To investigate the safety and effects (good and bad) of giving the PI3k inhibitor alpelisib (Piqray®) in combination with an anti-estrogen therapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer. You must have already received a CDK4/6 inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 1-2 times a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth daily, ongoing</li> <li class="seamTextUnorderedListItem">Letrozole, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Goserelin (Zoladex®) or leuprolide (Lupron®), by injection, monthly, ongoing (if you are a premenopausal woman or a man)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®) is a PI3K inhibitor. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) and letrozole (Femara®) are the anti-estrogen (hormone) drugs used in this study.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03056755' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/esmo-2018/alpelisib-combo-nearly-doubles-pfs-in-pik3camutant-breast-cancer' target='_blank'>OncLive: Alpelisib Combo Nearly Doubles PFS in PIK3CA</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.faslodex.com/what-is-faslodex.html' target='_blank'>AstraZeneca Drug Information Page: Faslodex® (Fulvestrant)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/hormone-therapy/ovarian-suppression-breast-cancer' target='_blank'>Breast Cancer Now: Ovarian Suppression</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer-in-men/treating/hormone-therapy.html' target='_blank'>American Cancer Society: Hormone Therapy for Breast Cancer in Men</a> </li></ul>
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26

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco,CA

VISITS: Number of visits unavailable, up to 2 years

PHASE: II

NCT ID: NCT03094052

Diarrhea Prevention for People With HER2+ Breast Cancer Receiving Neratinib Alone or With Herceptin

An Open Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early Stage HER2+ Breast Cancer Treated With Adjuvant Trastuzumab and Neratinib Followed by Neratinib Monotherapy, and Intensive Anti-diarrhea Prophylaxis Scientific Title

Purpose
To study whether taking anti-diarrhea medication can help prevent diarrhea in people being treated with neratinib (Nerlynx®) alone or in combination with trastuzumab (Herceptin®).
Who is this for?
People with stage II or stage III, HER2 positive (HER2+) breast cancer who have finished chemotherapy and radiation therapy and who are still receiving adjuvant trastuzumab (Herceptin®) or are within 1 year of finishing trastuzumab (Herceptin®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, as indicated by your doctor</li> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily, up to 2 years</li> <li class="seamTextUnorderedListItem">Loperamide, by mouth, daily for 6 weeks, then as needed</li> <li class="seamTextUnorderedListItem">Crofelemer (Mytesi®), by mouth, daily for 6 weeks, then as needed</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two approved HER2-targeted drugs used in this trial are trastuzumab (Herceptin®) and neratinib (Nerlynx®)</li> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®) is known to cause diarrhea.</li> <li class="seamTextUnorderedListItem">Crofelemer (Mytesi®) is a medicine used to prevent diarrhea in people being treated for HIV/AIDS. </li> <li class="seamTextUnorderedListItem">Loperamide (Immodium) is an over-the-counter medication used to prevent and treat diarrhea.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03094052' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.fulyzaq.com/' target='_blank'>Drug Company Information Page: Crofelemer (Mytesi)</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/web-exclusives/fda-accepts-neratinib-nda-for-her2positive-breast-cancer' target='_blank'>OncLive: Neratinib</a> </li></ul>
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27

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco,CA

VISITS: Visits every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03095352

Keytruda plus Carboplatin to Treat Chest Wall Breast Cancer

A Randomized Phase II Study of Pembrolizumab, an Anti-PD (Programmed Cell Death)-1 Antibody, in Combination With Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients With Chest Wall Disease Scientific Title

Purpose
To compare the safety and effects (good and bad) of giving immunotherapy along with chemotherapy vesus giving chemotherapy alone to treat breast cancer that has spread to the chest wall.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that has spread to the chest wall and cannot be removed by surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Biopsies and blood samples before and after treatment </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard treatment</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Biopsies and blood samples before and after treatment</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is the immunotherapy drug used in this study. It is a PDL-1 inhibitor approved to treat certain types of cancers. </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) is the chemotherapy drug used in this study.</li> <li class="seamTextUnorderedListItem">In this trial, researchers will test tumor biopsies and blood samples before and after treatment in order to learn more about how genes and the immune system affect how tumors respond to immunotherapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03095352' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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28

NEAREST SITE: 3 miles
California Pacific Medical Center-Pacific Campus
San Francisco,CA

VISITS: Weekly visits for 3-6 months; then 1 visit every 3 weeks, ongoing

PHASE: III

NCT ID: NCT03199885

Paclitaxel, Trastuzumab, & Pertuzumab With or Without Atezolizumab For Metastatic HER2+ Breast Cancer

A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer Scientific Title

Purpose
To compare the safety and effects of the combination of pertuzumab, trastuzumab, paclitaxel, and atezolizumab with the combination of pertuzumab, trastuzumab, paclitaxel, and a placebo.
Who is this for?
People who are starting treatment for metastatic (stage IV) breast cancer or have had their breast cancer recur after 6 months of neoadjuvant or adjuvant HER2-targeted therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pertuzumab, (Perjeta®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3-6 months</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pertuzumab, (Perjeta®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3-6 months</li> <li class="seamTextUnorderedListItem">Placebo, by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®) and trastuzumab (Herceptin®) are HER2-targeted therapies used to treat HER2 positive (HER2+) breast cancer. </li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy drug routinely used to treat breast cancer.</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is a type of immunotherapy called a PD-L1 inhibitor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03199885' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/patients/medicines/tecentriq' target='_blank'>Genentech Information Page: Tecentriq</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/perjeta' target='_blank'>Breastcancer.org: Perjeta® (Pertuzumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/targeted-therapy-for-breast-cancer.html' target='_blank'>American Cancer Society: Targeted Therapy for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/Taxol.aspx' target='_blank'>Chemocare: Taxol</a> </li></ul>
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29

NEAREST SITE: 3 miles
UCSF Helen Diller Family CCC
San Francisco,CA

VISITS: 1-2 visits a month, ongoing

PHASE: I-II

NCT ID: NCT03280563

Immunotherapies, Targeted Therapies, and Anti-Estrogen Therapies for Advanced Hormone Positive, HER2 Negative Breast Cancer

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Hormone Receptor-Positive HER2-Negative Breast Cancer (MORPHEUS-HR+ Breast Cancer) Scientific Title

Purpose
To evaluate the safety, effects (good and bad), and anti-cancer activity of several therapy combinations that include immunotherapies, targeted therapies, and anti-estrogen therapies.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) hormone receptor positive (ER+ and/or PR+), HER2 negative (ER+, HER2-) breast cancer. Your cancer must have recurred or progressed on your most recent treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 7 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 1-2 times a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, once a month, ongoing</li> <li class="seamTextUnorderedListItem">Entinostat, by mouth, once a week, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, twice a month, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 1-2 times a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, twice a month, ongoing</li> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily (3 weeks on, 1 week off), ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 5</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, twice a month, ongoing</li> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily (3 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 1-2 times a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 6</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, twice a month, ongoing</li> <li class="seamTextUnorderedListItem">Bevacizumab (Avastin®), by IV, twice a month, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) by injection or tamoxifen (Nolvadex®) or exemestane (Aromasin®) by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 7</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, twice a month, ongoing</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, twice a day, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 1-2 times a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">If your disease progresses while on treatment, you may be eligible to receive a new combination treatment.</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsies may be required</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is a type of immunotherapy called a PD-L1 checkpoint inhibitor. It is approved to treat locally advanced or metastatic triple-negative, PD-L1-positive breast cancer.</li> <li class="seamTextUnorderedListItem">Entinostat is an investigational type of targeted therapy called an HDAC inhibitor.</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a hormone therapy approved to treat postmenopausal women with advanced breast cancer.</li> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068) is a new type of cancer drug that works by blocking the Akt protein</li> <li class="seamTextUnorderedListItem">Bevacizumab (Avastin) is a monoclonal antibody that keeps tumors from growing by shrinking their supplying blood vessels. Avastin is used to treat HER2-negative metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®) is a CDK 4/6 inhibitor that is commonly used to treat metastatic, hormone positive (ER+ and/or PR+) breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03280563' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biooncology.com/pipeline-molecules/ipatasertib.html' target='_blank'>Genentech Drug Information Page: Ipatasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/patients/medicines/tecentriq' target='_blank'>Genentech Drug Information Page: Tecentriq</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/hormone-therapy/fulvestrant-faslodex' target='_blank'>Breast Cancer Now: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/entinostat' target='_blank'>NCI Drug Dictionary: Entinostat</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/avastin' target='_blank'>Breastcancer.org: Avastin</a> </li></ul>
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30

NEAREST SITE: 3 miles
UCSF Comprehensive Cancer Ctr
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03289962

Personalized Cancer Vaccine With or Without Atezolizumab for Advanced Triple Negative Breast Cancer

A Phase 1a/1b Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of RO7198457 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Tumors Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using a personalized cancer vaccine (RO7198457) alone or with an immunotherapy drug (the PD-LI inhibitor atezolizumab).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer. Your cancer must have progressed after receiving standard of care therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RO7198457, by IV, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RO7198457, by IV, ongoing</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The personalized cancer vaccine is called RO7198457. </li> <li class="seamTextUnorderedListItem">The immunotherapy being used in this study is the PD-L1 inhibitor atezolizumab (Tecentriq®). </li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) works by blocking the PD-L1 (programmed death-ligand 1) protein and is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03289962' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tecentriq-hcp.com' target='_blank'>Genentech Information Page: Tecentriq</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=791183' target='_blank'>NCI Drug Dictionary: RO7198457</a> </li></ul>
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31

NEAREST SITE: 3 miles
University of California San Francisco (UCSF)
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03326102

Oral Paclitaxel in HER2- Recurrent and Metastatic Breast Cancer (OPERA)

A Multi-center, Open-label, Phase 2 Clinical Trial to Evaluate the Efficacy, Safety and Pharmacokinetics of DHP107 (Liporaxel®, Oral Paclitaxel) Compared to IV Paclitaxel in Patients With Recurrent or Metastatic Breast Cancer (OPERA) Scientific Title

Purpose
To compare the safety and effects (good and bad) of paclitaxel taken by mouth with paclitaxel that is given through a vein (IV).
Who is this for?
People with HER2-negative recurrent or metastatic (stage IV) breast cancer that has been treated with up to three lines of therapy other than a taxane.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups in a 2:1 ratio (twice as many participants will be in Group 1 as compared to Group 2): </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Paclitaxel by mouth</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DHP107 by mouth, once a week, 3 weeks on/1 week off</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Paclitaxel by IV</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, once a week, 3 weeks on/1 week off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The IV form of paclitaxel (Taxol®) is approved to treat metastatic breast cancer in the U.S.</li> <li class="seamTextUnorderedListItem">The oral form (DHP107) is approved to treat metastatic breast cancer in Korea. There it is sold as Liporaxel®.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03326102' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/paclitaxel' target='_blank'>Cancer Research UK: Paclitaxel</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.1084' target='_blank'>Journal of Clinical Oncology: Oral paclitaxel in the treatment of metastatic breast cancer (MBC) patients</a> </li></ul>
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32

NEAREST SITE: 3 miles
University of California San Francisco
San Francisco,CA

VISITS: 2-3 visits a month, ongoing

PHASE: II

NCT ID: NCT03414658

Herceptin and Navelbine with One or Two Immunotherapies for Advanced HER2+ Breast Cancer

A Randomized, Phase II Study Comparing Trastuzumab and Vinorelbine in Combination With Avelumab or Avelumab and Utomilumab (41BB/CD137 Agonist), in Patients With HER2-positive Metastatic Breast Cancer Who Have Progressed on Prior Trastuzumab and Pertuzumab (AVIATOR) Scientific Title

Purpose
To study and compare the safety and anti-cancer activity of using trastuzumab (Herceptin®) and chemotherapy to using trastuzumab (Herceptin®), chemotherapy, and one or two experimental immunotherapies.
Who is this for?
People with advanced (stage III) or metastatic (stage IV) HER2 positive (HER2+) breast cancer.    Full eligibility criteria
Contact research site
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Vinorelbine (Navelbine®), by IV, 3 times over 1 month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Vinorelbine (Navelbine®), by IV, 3 times over 1 month</li> <li class="seamTextUnorderedListItem">Avelumab (Bevancio®), by IV, every 2 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Vinorelbine (Navelbine®), by IV, 3 times over 1 month</li> <li class="seamTextUnorderedListItem">Avelumab (Bevancio®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Utomilumab (PF-05082566), by IV, monthly</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) is a targeted therapy routinely used to for HER2 positive breast cancer.</li> <li class="seamTextUnorderedListItem">Vinorelbine (Navelbine®) is a chemotherapy drug used to for HER2 positive breast cancer.</li> <li class="seamTextUnorderedListItem">Avelumab (Bevancio®) and utomilumab (PF-05082566) are immunotherapies that work by stimulating the body's immune system to go after cancer cells. Both work by blocking a protein called PD-L1. </li> <li class="seamTextUnorderedListItem">Bevancio is approved to treat metastatic Merkel cell carcinoma and urothelial (bladder) cancers. Its use is considered experimental in breast cancer. </li> <li class="seamTextUnorderedListItem">Utomilumab is an experimental treatment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03414658' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/vinorelbine-navelbine' target='_blank'>Breast Cancer Care UK: Navelbine</a> </li><li class='seamTextUnorderedListItem'><a href='https://externalmediasite.partners.org/Mediasite/Play/203c8412eda144b7afc0aae750805b2c1d' target='_blank'>Dana-Farber Cancer Institute: Patient-friendly informational video about this trial</a> </li></ul>
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33

NEAREST SITE: 3 miles
Kaiser Permanente-San Francisco
San Francisco,CA

VISITS: Daily visits, for 3-6 weeks

PHASE: III

NCT ID: NCT03414970

Hypofractionated Radiation After Mastectomy to Prevent Recurrence in Stage II-III Breast Cancer

Phase III Randomized Trial of Hypofractionated Post Mastectomy Radiation With Breast Reconstruction Scientific Title

Purpose
To compare the safety and effects (good and bad) of hypofractionated radiation therapy to standard radiation therapy.
Who is this for?
People who had a mastectomy to treat stage II, stage IIIa, or stage IIIb breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Conventional radiation therapy, daily, 5 days a week, for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy, daily, 5 days a week for 3-4 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation is a type of radiation therapy in which larger doses (fractions) of radiation are given in fewer sessions over a shorter period of time than conventional radiation therapy.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03414970' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/shorter-radiation-better-for-early-stage' target='_blank'>Breastcancer.org: Shorter Radiation Course for Early Stage Breast Cancer</a> </li></ul>
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34

NEAREST SITE: 3 miles
UCSF Medical Center
San Francisco,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I

NCT ID: NCT03454451

CPI-006 Alone or With CPI-444 or Keytruda in Advanced Triple Negative Breast Cancer

A Phase 1/1b Multicenter Study To Evaluate The Humanized Anti-CD73 Antibody, CPI-006, As A Single Agent, In Combination With CPI-444, And In Combination With Pembrolizumab In Adult Subjects With Advanced Cancers Scientific Title

Purpose
To test the safety and effects (good and bad) of CPI-006 when it is given alone or with CPI-444 or with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer that has not responded to other treatment options.    Full eligibility criteria
Contact research site
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CPI-006, by IV, once every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CPI-006, by IV, once every 3 weeks</li> <li class="seamTextUnorderedListItem">CPI-444, by mouth, twice daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CPI-006, by IV, once every 3 weeks</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CPI-006 is an investigational immunotherapy that gets the immune system to after cancer cells by targeting CD73. </li> <li class="seamTextUnorderedListItem">CPI-444 is an investigational immunotherapy that targets the adenosine-A2A receptor (ADORA2A) on immune cells. </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking PD-1. </li> <li class="seamTextUnorderedListItem">Keytruda is approved to treat certain types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03454451' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.2505' target='_blank'>Journal of Clinical Oncology: CPI-006, an anti-CD73 antibody with immune modulating activity, in a phase 1 trial in advanced cancers</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/adenosine-a2a-receptor-antagonist-cpi-444' target='_blank'>NCI Drug Dictionary: adenosine-A2A receptor antagonist CPI-444</a> </li></ul>
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35

NEAREST SITE: 3 miles
University of California San Francisco Medical Center
San Francisco,CA

VISITS: 4 visits over 2 months

PHASE: I

NCT ID: NCT03517488

XmAb20717 Immunotherapy for Advanced Triple Negative Breast Cancer

A Phase 1 Multiple Dose Study to Evaluate the Safety and Tolerability of XmAb20717 in Subjects With Selected Advanced Solid Tumors (DUET-2) Scientific Title

Purpose
To test the safety, effects (good and bad) and best dose of an experimental immunotherapy called XmAb20717.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) that has not responded to other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">XmAb20717, by IV, once every 2 weeks, for 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">XmAb20717 blocks two proteins on immune cells, PD-1 and CTLA4. </li> <li class="seamTextUnorderedListItem">Blocking these proteins helps your immune system see and go after cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03517488' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793410' target='_blank'>NCI drug dictionary: XmAb20717</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.prnewswire.com/news-releases/xencor-doses-first-patient-in-phase-1-study-of-xmab20717-dual-checkpoint-inhibitor-for-the-treatment-of-advanced-solid-tumors-300680374.html' target='_blank'>Xencor press release: XmAb20717</a> </li></ul>
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36

NEAREST SITE: 3 miles
University of California -San Francisco
San Francisco,CA

VISITS: Weekly visits for 2 months, monthly visits thereafter

PHASE: II

NCT ID: NCT03519178

PF-06873600 for Metastatic HER2-Negative Breast Cancer

Phase 1/2a Dose Escalation And Expansion Study Evaluating Safety, Tolerability, Pharmacokinetic, Pharmacodynamics And Anti-tumor Activity Of Pf-06873600 As A Single Agent And In Combination With Endocrine Therapy Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of PF-06873600, a new targeted therapy.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or hormone receptor (ER+ and/or PR+) positive, HER2 negative (HER2-) breast cancer who have already received a CDK 4/6 inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PF-06873600, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PF-06873600, by mouth</li> <li class="seamTextUnorderedListItem">Endocrine therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PF-06873600 is a cyclin-dependent kinase (CDK) inhibitor. </li> <li class="seamTextUnorderedListItem">It works by inhibiting the CDK enzymes that help cancer cells grow. </li> <li class="seamTextUnorderedListItem">Patients in the study with hormone-receptor positive breast cancer will also be treated with an anti-estrogen therapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03519178' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793673' target='_blank'>NCI Drug Dictionary: PF-06873600</a> </li></ul>
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37

NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03554044

Imlygic With Taxol or Hormone Therapy for Advanced HER2 Negative Breast Cancer

A Phase 1b Study of Talimogene Laherparepvec (T-VEC) in Combination With Paclitaxel or Endocrine Therapy in Patients With Metastatic, Unresectable, or Locoregionally Recurrent HER2-Negative Breast Cancer With Evidence of Injectable Disease in the Locoregional Area Scientific Title

Purpose
To study the safety, anti-tumor activity and effects (good and bad) of combining talimogene laherparepvec (Imlygic®) with paclitaxel (Taxol®) or a hormone therapy of their doctor's choice.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Estrogen receptor negative</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talimogene laherparepvec (Imlygic®), by injection, every 2 weeks for 3 months, then every 3 weeks</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, every week</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Estrogen receptor positive</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talimogene laherparepvec (Imlygic®), by injection, every 2 weeks for 3 months, then every 3 weeks</li> <li class="seamTextUnorderedListItem">Hormone therapy (doctor's choice)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talimogene laherparepvec (Imlygic®) is an immunotherapy approved to treat advanced melanoma. It is injected directly into a tumor site. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy drug used to treat advanced breast cancer. </li> <li class="seamTextUnorderedListItem">Paclitaxel will be used with Imylgic® to treat estrogen receptor negative (ER-) patients. </li> <li class="seamTextUnorderedListItem">Study participants with estrogen receptor positive (ER+) tumors will be treated with Imylgic® and a hormone therapy selected by their doctor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03554044' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/talimogene-laherparepvec' target='_blank'>NCI Dictionary of Cancer Terms: Talimogene Laherparepvec</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancernetwork.com/breast-cancer/adding-oncolytic-virus-neoadjuvant-chemo-triple-negative-breast-cancer' target='_blank'>Cancer Network: Adding an Oncolytic Virus to Neoadjuvant Chemo for Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/paclitaxel-taxol' target='_blank'>Breast Cancer Now: Paclitaxel (Taxol®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/types/recur_metast/treat_metast/options/hormonal' target='_blank'>Breastcancer.org: Hormonal Therapy to Treat Metastatic Breast Cancer</a> </li></ul>
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38

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Centre
San Francisco,CA

VISITS: 21 visits over 2 years

PHASE: III

NCT ID: NCT03562637

OB-822 & OBI-821 for Early-Stage Triple Negative Breast Cancer at High Risk for Recurrence

A Phase III, Randomized, Double-blind, Placebo Controlled Study of Adagloxad Simolenin (OBI 822)/OBI 821 Treatment for High Risk Early Stage Triple Negative Breast Cancer Patients, Defined as Residual Invasive Disease Following Neoadjuvant Chemotherapy OR ≥4 Positive Axillary Nodes Scientific Title

Purpose
To see if treating patients at risk for recurrence with an immunotherapy reduces the risk of the cancer coming back.
Who is this for?
People with early stage (stage I, II and IIIA) triple negative (ER-/PR-/HER2-) breast cancer who have completed chemotherapy. You must have cancer cells remaining if you had neoadjuvant (before surgery) chemotherapy or had 4 or more positive lymph nodes at the time of surgery if you had adjuvant (after surgery) chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Adagloxad simolenin (OBI-822) combined with OBI-821, by injection, 21 times over 2 years </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by injection, 21 times over 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Adagloxad simolenin (OBI-822) is the investigational immunotherapy used in this study. </li> <li class="seamTextUnorderedListItem">It is given along with the investigational drug OBI-821, which is designed to help stimulate the immune system to fight cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03562637' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/adagloxad-simolenin/' target='_blank'>Immuno-Oncology News: Adagloxad Simolenin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/saponin-based-immunoadjuvant-obi-821' target='_blank'>NCI: OBI-821</a> </li></ul>
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39

NEAREST SITE: 3 miles
University of California San Francisco
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03659136

Xentuzumab, Everolimus and Exemestane in Advanced HR Positive, HER2 Negative Breast Cancer

XENERA™-1: A Multi-centre, Double-blind, Placebo-controlled, Randomised Phase II Trial to Compare Efficacy of Xentuzumab in Combination With Everolimus and Exemestane Versus Everolimus and Exemestane in Post-menopausal Women With HR+ / HER2- Metastatic Breast Cancer and Non-visceral Disease Scientific Title

Purpose
To compare the effects (good and bad) of the combination of xentuzamab, everolimus (Afinitor®), and exemestane (Aromasin®) to the combination everolimus (Afinitor®) and exemestane (Aromasin®).
Who is this for?
Postmenopausal women advanced (some stage III) or metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Xentuzumab, by IV</li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth</li> <li class="seamTextUnorderedListItem">Exemestane (Aromasin®), by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV</li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth</li> <li class="seamTextUnorderedListItem">Exemestane (Aromasin®), by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Xentuzumab is an investigational targeted therapy that blocks insulin-like growth factor (IGF). </li> <li class="seamTextUnorderedListItem">Studies suggest it may improve how cancer cells respond to chemotherapy. </li> <li class="seamTextUnorderedListItem">Aromasin is an anti-estrogen drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Afinitor is a chemotherapy drug used to treat advanced HR positive HER2 negative breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03659136' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-17764/exemestane-oral/details' target='_blank'>WebMD: Exemestane</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/everolimus' target='_blank'>Cancer Research UK: Everolimus (Afinitor®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/xentuzumab' target='_blank'>NCI Drug Dictionary: Xentuzumab</a> </li></ul>
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40

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco,CA

VISITS: At least 2 visits every 3 weeks

PHASE: I-II

NCT ID: NCT03678883

9-ING-41 Targeted Therapy With or Without Chemotherapy for Patients With Advanced Breast Cancer

Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3β) Inhibitor, as a Single Agent and Combined With Chemotherapy, in Patients With Refractory Hematologic Malignancies or Solid Tumors Scientific Title

Purpose
To determine the safety and the effects (good and bad) of the investigational targeted therapy 9-ING-41 when it is used with or without chemotherapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no other standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to receive: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Experimental drug alone</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">9-ING-41, by IV, 2 times every 3 weeks </li> </ul> <p class="seamTextPara"> or </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Experimental drug plus chemo</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">9-ING-41, by IV, 2 times every 3 weeks</li> <li class="seamTextUnorderedListItem">Chemotherapy (one of the following: gemcitabine, doxorubicin, lomustine, carboplatin, nab-paclitaxel plus gemcitabine, or paclitaxel plus carboplatin)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The drug 9-ING-41 is a type of targeted therapy called a GSK-3β inhibitor. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03678883' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.ucsf.edu/trial/NCT03678883' target='_blank'>UCSF trial information</a> </li></ul>
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41

NEAREST SITE: 3 miles
University of California San Francisco (UCSF)
San Francisco,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03717415

Targeted Therapy Rebastinib With Carboplatin for Advanced Triple Negative Breast Cancer

An Open Label, Multicenter, Phase 1b/2 Study of Rebastinib (DCC-2036) in Combination With Carboplatin to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To study the safety, dose and effects (good and bad) of the targeted therapy rebastinib (DCC-2036) when used along with carboplatin (Paraplatin®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rebastinib (DCC-2036), by mouth, daily</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rebastinib targets a receptor called TIE2. Researchers believe blocking this protein will keep tumors from growing and spreading. </li> <li class="seamTextUnorderedListItem">Paraplatin is a chemotherapy drug routinely used to treat advanced and metastatic triple negative breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03717415' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/rebastinib-tosylate' target='_blank'>NCI: rebastinib tosylate</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.deciphera.com/pipeline/rebastinib/' target='_blank'>Trial Sponsor (Deciphera): Rebastinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://investors.deciphera.com/news-releases/news-release-details/deciphera-pharmaceuticals-reports-updated-preliminary-phase-1' target='_blank'>Trial Sponsor (Deciphera): Press release</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/carboplatin#who' target='_blank'>Breastcancercare.org.uk: Carboplatin</a> </li></ul>
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42

NEAREST SITE: 3 miles
University of California at San Francisco (PARENT)
San Francisco,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: III

NCT ID: NCT03734029

Trastuzumab Deruxtican (DS-8201a) for Advanced HER2 Low Expression Breast Cancer

A Phase 3, Multicenter, Randomized, Open-label, Active Controlled Trial of DS-8201a, an Anti-HER2-antibody Drug Conjugate (ADC), Versus Treatment of Physician's Choice for HER2-low, Unresectable and/or Metastatic Breast Cancer Subjects [DESTINY-Breast04] Scientific Title

Purpose
To compare the safety and effects (good and bad) of the targeted therapy trastuzumab deruxtican (DS-8201a) to the standard of care.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 low expression breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab deruxtican (DS-8201a), by IV, 1 time every 3 weeks, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy chosen by your doctor: Capecitabine (Xeloda®), Eribulin (Halaven®), Gemcitabine (Gemzar®), Paclitaxel (Taxol®), or Nab-paclitaxel (Abraxane®)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HER2 low expression is defined as IHC 1+ or IHC 2+/ISH-</li> <li class="seamTextUnorderedListItem">Trastuzumab deruxtican (DS-8201a) is an antibody-drug conjugate (ADC). It uses a HER2 antibody to deliver a topoisomerase I inhibitor directly to cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03734029' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-grants-ds8201-breakthrough-designation-for-her2-breast-cancer' target='_blank'>OncLive: FDA Grants DS-8201 Breakthrough Designation for HER2+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-her2-adc-ds-8201a' target='_blank'>NCI: anti-HER2 ADC DS-8201a</a> </li></ul>
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43

NEAREST SITE: 3 miles
UCSF Cancer Center
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03781063

Lasofoxifene or Fulvestrant in Advanced ER+, HER2- Breast Cancer with a ESR1 Mutation

An Open-Label, Randomized, Multicenter Study Evaluating the Activity of Lasofoxifene Relative to Fulvestrant for the Treatment of Postmenopausal Women With Locally Advanced or Metastatic ER+/HER2− Breast Cancer With an ESR1 Mutation Scientific Title

Purpose
To compare the safety and effects (good and bad) of lasofoxifene (Fablyn®) to fulvestrant (Faslodex®).
Who is this for?
Postmenopausal women with advanced (stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have received an aromatase inhibitor combined with a CDK 4/6 inhibitor, and have had a cell-free circulating tumor DNA (cDNA) test that shows your tumor has an ESR1 mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lasofoxifene (Fablyn®), by mouth, daily </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, once a month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fablyn is a nonsteroidal selective estrogen receptor modulator (SERM). </li> <li class="seamTextUnorderedListItem">It has been approved for use in other countries to treat osteoporosis, but is not approved in the U.S. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a hormone therapy approved to treat postmenopausal women with advanced breast cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: ESR1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03781063' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/hormone-therapy/fulvestrant-faslodex' target='_blank'>BreastCancerCare.org.uk: Fulvestrant (Faslodex)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.practiceupdate.com/content/lasofoxifene-vs-fulvestrant-for-hr-positive-breast-cancer/77342' target='_blank'>PracticeUpdate: Lasofoxifene vs Fulvestrant for HR-Positive Breast Cancer</a> </li></ul>
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44

NEAREST SITE: 3 miles
UCSF Mount Zion Cancer Center
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT03786094

Eribulin With or Without Balixafortide in HER2 Negative Advanced Breast Cancer

An International, Phase 3, Multicenter, Randomized, Open- Label Trial Comparing Balixafortide in Combination With Eribulin Versus Eribulin Alone in Patients With HER2 Negative, Locally Recurrent or Metastatic Breast Cancer Scientific Title

Purpose
To compare the safety, effectiveness and side effects of using eribulin (Halaven®) alone or in combination with balixafortide.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative breast cancer that has been treated with chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eribulin (Halaven®), by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eribulin (Halaven®), by injection</li> <li class="seamTextUnorderedListItem">Balixafortide (POL6326), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Halaven is a chemotherapy drug used to treat advanced breast cancer. </li> <li class="seamTextUnorderedListItem">Balixafortide is an investigational immunotherapy drug that targets CXCR4.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03786094' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/eribulin' target='_blank'>Cancer Research UK: Eribulin (Halaven)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.targetedonc.com/news/fda-grants-balixafortide-fast-track-designation-for-treatment-of-metastatic-breast-cancer-subset' target='_blank'>Targeted Oncology: FDA Grants Balixafortide Fast Track Designation for Treatment of MBC Subset</a> </li></ul>
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45

NEAREST SITE: 3 miles
Quest Clinical Research
San Francisco,CA

VISITS: Weekly visits, ongoing

PHASE: I-II

NCT ID: NCT03838367

Leronlimab & Carboplatin for Metastatic Triple Negative Breast Cancer That Tests CCR5+

A Phase Ib/II Study of Leronlimab (PRO 140) Combined With Carboplatin in Patients With CCR5+ Metastatic Triple Negative Breast Cancer (mTNBC) Scientific Title

Purpose
To determine the best dose, safety and effects (good and bad) of leronlimab when it is used along with carboplatin.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that the researchers find tests positive for CCR5 and not have been treated with chemotherapy or a checkpoint inhibitor for metastatic breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leronlimab (PRO 140), by injection, weekly </li> <li class="seamTextUnorderedListItem">Carboplatin, by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leronlimab is an investigational targeted therapy that blocks CCR5. </li> <li class="seamTextUnorderedListItem">Carboplatin is a chemotherapy drug used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03838367' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.globenewswire.com/news-release/2019/05/07/1818129/0/en/FDA-Grants-CytoDyn-Fast-Track-Designation-for-Leronlimab-PRO-140-in-metastatic-Triple-Negative-Breast-Cancer-an-Unmet-Medical-Need.html' target='_blank'>Drug company information page: Leronlimab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-grants-fast-track-designation-to-leronlimab-for-metastatic-tnbc' target='_blank'>Onclive: Leronlimab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/carboplatin' target='_blank'>Breastcancer.org: Carboplatin</a> </li></ul>
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46

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco,CA

VISITS: 2 visits every 3 weeks; or coincides with chemotherapy treatment

PHASE: III

NCT ID: NCT03901339

Sacituzumab Govitecan in Advanced Hormone Positive, HER2 Negative Breast Cancer (TROPICS-02)

Phase 3 Study of Sacituzumab Govitecan vs Physician's Choice in Subjects With Hormonal Receptor-Positive Human Epidermal Growth Factor Receptor 2 Negative Metastatic Breast Cancer Who Have Failed at Least 2 Prior Chemotherapy Regimens Scientific Title

Purpose
To compare the safety and effects (good and bad) of sacituzumab govitecan to standard of care chemotherapy.
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer that has already been treated with 2 to 4 different chemotherapy regimens.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sacituzumab Govitecan (IMMU-132), by IV, 2 times every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy (eribulin, capecitabine, gemcitabine, or vinorelbine), determined by your physician</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The investigational chemotherapy is called sacituzumab govitecan (IMMU-132). </li> <li class="seamTextUnorderedListItem">It is approved for use in some people with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.</li> <li class="seamTextUnorderedListItem">It is an antibody-drug conjugate (ADC). This means it uses an antibody that targets cancer cells to deliver a chemotherapy drug directly to these cells. </li> <li class="seamTextUnorderedListItem">The antibody in this drug targets TROP2 proteins. </li> <li class="seamTextUnorderedListItem">It delivers the chemotherapy drug SN-38.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03901339' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/latest-news/fda-approves-trodelvy-sacituzumab-govitecan-hziy-for-triple-negative-breast-cancer.html' target='_blank'>American Cancer Society: FDA Approves Trodelvy (Sacituzumab Govitecan-Hziy) for Triple Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2019/05/01/mbc-news-11/' target='_blank'>MetastaticTrialTalk: Getting to the Target, Antibody Drug Conjugates in Breast Cancer</a> </li></ul>
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47

NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: At least 1 visit per month for 6 months

PHASE: I

NCT ID: NCT03970382

Personalized Immunotherapy With or Without Opdivo for Metastatic Hormone Positive Breast Cancer

A Phase 1a/1b, Open-label First-in-human Study of the Safety, Tolerability and Feasibility of Gene-edited Autologous NeoTCR-T Cells (NeoTCR-P1) Administered as a Single Agent or in Combination With Anti-PD-1 to Patients With Locally Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To determine the safety and the effects (good or bad) of an experimental T-cell immunotherapy called neoTCR-P1 when it is given with or without nivolumab (Opdivo®).
Who is this for?
People with metastatic (stage IV) hormone receptor positive (ER+ and/or PR+) breast cancer that has been treated with at least one standard therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NeoTCR-P1, one time </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NeoTCR-P1, one time </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), once a month, for 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NeoTCR-P1 makes a patient's T-cells target a neoepitope (neoE) that is found on their cancer cells. </li> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). It has been approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03970382' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/798453' target='_blank'>NCI Drug Dictionary: gene-edited autologous neoantigen-targeted NeoTCR-P1 T cells</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/nivolumab' target='_blank'>NCI Drug Dictionary: Nivolumab</a> </li></ul>
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48

NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: 1 visit every 2 weeks, ongoing

PHASE: II

NCT ID: NCT03971409

Avelumab With Binimetinib, Utomilumab, or PF-04518600 For Advanced Triple Negative & ER-Low Breast Cancer

Innovative Combination Immunotherapy for Metastatic Triple Negative Breast Cancer (TNBC): A Multicenter, Multi-Arm Translational Breast Cancer Research Consortium Study (InCITe) Scientific Title

Purpose
To look at the safety and effects (good and bad) of combining the immunotherapy drug avelumab (Bavencio®) with binimetinib, utomilumab, or PF-04518600.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) or ER-Low (1%-10% ER) breast cancer who have not had more than three lines of chemotherapy and not more than one checkpoint inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Binimetinib, by mouth, twice daily</li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, every 2 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PF-04518600, by IV, every 2 weeks </li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, every 2 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Utomilumab, by IV, once a month</li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, every 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Bavencio is type of immunotherapy called a PD-L1 inhibitor. It has been approved to treat certain types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Binimetinib (Mektovi®) is targeted therapy that blocks MEK, which helps cancer cells grow. It is used to treat metastatic melanoma. Its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">PF-04518600 is an investigational immunotherapy that targets OX40, a protein found on immune cells that have interacted with cancer cells. </li> <li class="seamTextUnorderedListItem">Utomilumab is an investigational immunotherapy that targets the 4-1BB (CD-137) protein on certain immune cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03971409' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/avelumab' target='_blank'>NCI Drug Dictionary: Avelumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/pf-04518600/' target='_blank'>Immuno-Oncology News: PF-04518600</a> </li><li class='seamTextUnorderedListItem'><a href='https://pfe-pfizercom-prod.s3.amazonaws.com/news/asco/Pfizer_IO_41BB_UtomilumabFactSheet.pdf' target='_blank'>Pfizer oncology: Utomilumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.arraybiopharma.com/our-science/our-pipeline/binimetinib' target='_blank'>Array Biopharma: BINIMETINIB</a> </li></ul>
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49

NEAREST SITE: 3 miles
University of California San Francisco Medical Center
San Francisco,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I

NCT ID: NCT04042701

Trastuzumab Deruxtican (DS-8201a) and Pembrolizumab for Advanced HER2 Positive and HER2 Low Expression Breast Cancer

A Phase 1b, Multicenter, Two-Part, Open-Label Study of Trastuzumab Deruxtecan (DS-8201a), An Anti-Human Epidermal Growth Factor Receptor-2 (HER2)-Antibody Drug Conjugate (ADC), In Combination With Pembrolizumab, An Anti-PD-1 Antibody, In Subjects With Locally Advanced/Metastatic Breast Or Non-Small Cell Lung Cancer (NSCLC) Scientific Title

Purpose
To find the best dose and to study the safety, effects (good and bad), and anti-tumor activity of the HER2-targeted therapy trastuzumab deruxtican (DS-8201a) when it is given along with the immunotherapy drug pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+) or HER2 low expression breast cancer whose cancer progressed after receiving trastuzumab emtansine (T-DM1) or standard of care therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab deruxtican (DS-8201a), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HER2 low expression is defined as IHC 1+ or 2+ and ISH-.</li> <li class="seamTextUnorderedListItem">DS-8201a (trastuzumab deruxtecan) is an antibody-drug conjugate (ADC). It targets HER2 to deliver a chemotherapy drug directly to the cancer cells. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">Blocking PD-1 allows the body's immune system to detect and fight cancer cells.</li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04042701' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-her2-adc-ds-8201a' target='_blank'>NCI Drug Dictionary: DS8201a</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/cancer-types/breast-cancer-metastatic/types-treatment' target='_blank'>ASCO: Metastatic Breast Cancer, Types of Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2020/tucatinib-trastuzumab-deruxtecan-her2-positive-metastatic-breast-cancer' target='_blank'>NCI Cancer Currents Blog: For Metastatic HER2-Positive Breast Cancer, New Treatments Emerge</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.daiichisankyo.com/media_investors/media_relations/press_releases/detail/006963.html' target='_blank'>Press Release: HER2 Low Expression</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/lynn-sage-2019/immunotherapy-for-breast-cancer-whats-new-and-whats-on-the-horizon?p=1' target='_blank'>OncLive: Immunotherapy for Breast Cancer: What's New and What's on the Horizon?</a> </li></ul>
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50

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT04171700

PARP Inhibitor Rucaparib in Advanced Breast Cancer that is BRCA+ (Inherited or Tumor) or Tests Positive for Other Mutations

A Phase 2 Multicenter, Open-label Study of Rucaparib as Treatment for Solid Tumors Associated With Deleterious Mutations in Homologous Recombination Repair Genes (LODESTAR) Scientific Title

Purpose
To look at the safety, effects (good and bad), and anti-tumor activity of the PARP inhibitor rucaparib (Rubraca®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have been treated with at least one standard of care therapy but no more than two lines of chemotherapy; and who have inherited (or whose tumor tests positive for) one of the several mutations listed below.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rucaparib (Rubraca®), by mouth, twice a day, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rucaparib (Rubraca®) is a PARP inhibitor: it blocks poly (ADP-ribose) polymerase, an enzyme that helps cancer cells grow by repairing their DNA. It is approved to treat women with advanced ovarian cancer whose tumors have a BCRA 1 or BRCA 2 mutation. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">People with an inherited BRCA 1 or BRCA 2 mutation and whose tumor is HER2 negative (HER2-) tumor are not eligible for this trial. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: BRCA1 (tumor or inherited), BRCA2 (tumor or inherited), PALB2, RAD51C, RAD51D, BARD1, BRIP1, FANCA, NBN, RAD51 or RAD51B</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04171700' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.rubraca.com/?utm_source=google&utm_medium=cpc&utm_term=rucaparib&utm_campaign=Branded_Alone_GS_EX&gclid=Cj0KCQiAsbrxBRDpARIsAAnnz_OQBEzA3MVbEPTW02l-js4vH6_2yBSOiLDwbWxO914whM6BmwDeWMsaAse7EALw_wcB' target='_blank'>Drug Company Information Page: Rubraca® (Rucaparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2019/02/04/mbc-news-8/' target='_blank'>Metastatic Trial Talk: Get the Latest News on PARP Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://oncologypro.esmo.org/oncology-in-practice/anti-cancer-agents-and-biological-therapy/parp-inhibition-and-dna-damage-response-ddr/parp-inhibitors/clinical-activity/breast-cancer/ongoing-developments' target='_blank'>ESMO Oncology: PARP Inhibitors in Breast Cancer (HRR Gene Mutations)</a> </li></ul>
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51

NEAREST SITE: 3 miles
UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0138)
San Francisco,CA

VISITS: At least 3 visits a month, ongoing

PHASE: II-III

NCT ID: NCT04191135

Two Chemotherapies Plus Immunotherapy With or Without A Targeted Therapy for Advanced Triple Negative Breast Cancer

An Open-label, Randomized, Phase 2/3 Study of Olaparib Plus Pembrolizumab Versus Chemotherapy Plus Pembrolizumab After Induction of Clinical Benefit With First-line Chemotherapy Plus Pembrolizumab in Participants With Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer (TNBC) (KEYLYNK-009) Scientific Title

Purpose
To study the anti-cancer activity and effects (good and bad) of adding the targeted therapy olaparib (Lynparza®) to the treatment combination of carboplatin (Paraplatin®), gemcitabine (Gemzar®), and the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have not started treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, weekly (2 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, weekly (2 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, weekly (2 weeks on, 1 week off), for 3 to 5 months</li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, weekly (2 weeks on, 1 week off), for 3 to 5 months</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks, for 3 to 5 months</li> </ul> <p class="seamTextPara"> Then you will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, weekly (2 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a PARP inhibitor. It stops the growth of cancer cells by blocking enzymes called poly ADP ribose polymerase (PARP). </li> <li class="seamTextUnorderedListItem">It is approved to treat HER2-negative metastatic breast cancer in women with a hereditary BRCA genetic mutation. </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) is a chemotherapy drug routinely used to treat advanced and metastatic triple negative breast cancer. </li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®)is a chemotherapy drug used to treat breast cancer.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. It is approved to treat certain types of cancers. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04191135' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparza.com/breast-cancer/breast-cancer-types/triple-negative.html' target='_blank'>AstraZeneca Information Page: Lynparza® (Olaparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/carboplatin' target='_blank'>Breast Cancer Now: Carboplatin</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Gemcitabine' target='_blank'>Wikipedia: Gemcitabine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology: Keytruda®</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/publications/cure/2019/immunotherapy-2019/breast-cancer-gets-a-boost-from-immunotherapy' target='_blank'>Cure Today: Breast Cancer Gets a Boost From Immunotherapy</a> </li></ul>
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52

NEAREST SITE: 8 miles
Epic Care Partners in Cancer Care
Emeryville,CA

VISITS: Daily visits for 5 or 6.5 weeks

PHASE: NA

NCT ID: NCT01872975

Additional Radiation for Women with Stage I-III Breast Cancer Who Received Chemotherapy before Breast Surgery

A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant... Scientific Title

Purpose
To see if additional radiation after surgery reduces the risk of recurrence in women whose lymph node status changed from positive to negative after neoadjuvant chemotherapy.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who received neoadjuvant (before surgery) chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Post-Lumpectomy Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Whole Breast Radiation, 5 days a week, for 5 weeks</li> <li class="seamTextUnorderedListItem">Radiation therapy boost to the lumpectomy cavity, 5 days a week, for 1.5 weeks </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Post-Mastectomy Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No radiation</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Post-Lumpectomy Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Whole Breast Radiation, 5 days a week, for 5 weeks</li> <li class="seamTextUnorderedListItem">Regional nodal radiation therapy</li> <li class="seamTextUnorderedListItem">Radiation therapy boost to the lumpectomy cavity, 5 days a week, for 1.5 weeks </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4: Post-Mastectomy Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Regional nodal and chest wall radiation therapy, 5 days a week, for 5 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">4 Quality of Life questionnaires, over 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy given before surgery (neoadjuvant treatment) can kill cancer cells in the lymph nodes. This means a woman who is initially node positive may be node negative at the time of surgery.</li> <li class="seamTextUnorderedListItem">The standard of care for women with early-stage breast cancer who have a lumpectomy is whole-breast radiation.</li> <li class="seamTextUnorderedListItem">Women who have a mastectomy typically do not receive radiation.</li> <li class="seamTextUnorderedListItem">Giving radiation to the lymph nodes following a lumpectomy and giving radiation to the chest wall and lymph nodes following a mastectomy may reduce the risk of recurrence.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01872975' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li></ul>
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53

NEAREST SITE: 8 miles
Epic Care
Emeryville,CA

VISITS: Approximately 5 visits

PHASE: NA

NCT ID: NCT01992250

Cryoablation (Freezing) Instead of Surgery for Women Age 50+ With Small Tumors

Freezing Alone Instead of Resection and Radiotherapy Of Small Breast Tumors: A Study of Cryoablation in the Management of Prognostically Favorable Early Stage Breast Cancer in Elderly Women (FROST Trial) Scientific Title

Purpose
To compare the effects (good and bad) of using cryoablation instead of surgery on small tumors.
Who is this for?
Women, age 50 and older, with stage I hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer whose tumor is 1.5 cm or smaller.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups depending on your age: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Age 50 to 69</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation of your tumor</li> <li class="seamTextUnorderedListItem">Standard of care radiation therapy</li> <li class="seamTextUnorderedListItem">Your doctor's choice of hormone therapy, for 5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Age 70 or Older</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation of your tumor</li> <li class="seamTextUnorderedListItem">Your doctor's choice of hormone therapy, for 5 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation uses extreme cold to destroy cancer cells.</li> <li class="seamTextUnorderedListItem">The procedure involves using an ultrasound to pass a thin metal probe through the center of the tumor and then cooling the probe to an extremely low temperatures to freeze and kill the cancer cells. </li> <li class="seamTextUnorderedListItem">The procedure does not leave significant scarring.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01992250' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/annual-report/annual-report-2016/breast-cancer-treatment.html' target='_blank'>MD Anderson Cancer Center: Treatment puts the Freeze on Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/News/59564' target='_blank'>ASCO: Preliminary Results of Primary Cryoablation in Treating Low-Risk Breast Cancers</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertherapyadvisor.com/home/cancer-topics/breast-cancer/cryosurgery-the-future-of-breast-cancer-treatment/' target='_blank'>Cancer Therapy Advisor: Cryosurgery, The Future of Breast Cancer Treatment?</a> </li></ul>
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54

NEAREST SITE: 8 miles
Kaiser Permanente Cancer Treatment Center
South San Francisco,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03488693

Radiation or No Radiation to Treat Low Risk Node Positive Breast Cancer

TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer (TAILOR RT) Scientific Title

Purpose
To compare the effects (good and bad) of radiation therapy to no radiation therapy in patients with low-risk breast cancer who have had surgery.
Who is this for?
Women with early stage (stage I, II or IIIa) breast cancer who has been treated with breast cancer surgery and has an Oncotype DX recurrence score less than 18.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation (following breast surgery)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No radiation (following breast surgery)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation is given to reduce the risk of the cancer coming back in the breast. </li> <li class="seamTextUnorderedListItem">It is not known if radiation therapy after surgery improves outcomes in women with low-risk breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03488693' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/SideEffectsofRadiationTherapy.html' target='_blank'>Susan G. Komen: Side Effects of Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.eortc.org/blog/2018/03/23/many-women-with-early-breast-cancer-have-a-very-low-risk-of-a-locoregional-recurrence-five-years-after-surgery/' target='_blank'>European Organisation for Research and Treatment of Cancer: Many women with early breast cancer have a very low risk of a locoregional recurrence 5 years after surgery</a> </li></ul>
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55

NEAREST SITE: 8 miles
Epic Care Partners in Cancer Care
Emeryville,CA

VISITS: 5 visits per week, for 6 weeks

PHASE: II

NCT ID: NCT03598257

Radiation Therapy With or Without Olaparib For Inflammatory Breast Cancer

A Phase II Randomized Trial of Olaparib (NSC-747856) Administered Concurrently With Radiotherapy Versus Radiotherapy Alone for Inflammatory Breast Cancer (SWOG 1706) Scientific Title

Purpose
To compare the benefits and the effects (good and bad) of using radiation therapy along with a PARP inhibitor to radiation therapy alone.
Who is this for?
People with stage III inflammatory breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily, for 6 weeks</li> <li class="seamTextUnorderedListItem">Radiation therapy, 5 days a week, for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy, 5 days a week, for 6 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The PARP inhibitor being used in this study is olaparib (Lynparza®). It is approved to treat HER2-negative metastatic breast cancer in women with an inherited BRCA1/2 mutation. </li> <li class="seamTextUnorderedListItem">PARP inhibitors work by blocking the action of poly (ADP-ribose) polymerase, an enzyme that helps repair DNA. </li> <li class="seamTextUnorderedListItem">Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03598257' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2018/fda-olaparib-breast-brca-mutations' target='_blank'>NCI: Olaparib Approved for Treating Some Breast Cancers with BRCA Gene Mutations</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/olaparib' target='_blank'>NCI: Olaparib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/types/inflammatory' target='_blank'>Breastcancer.org: Inflammatory Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.swog.org/clinical-trials/s1706' target='_blank'>SWOG Cancer Research Network: Trial information</a> </li></ul>
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56

NEAREST SITE: 8 miles
Epic Care Partners in Cancer Care
Emeryville,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03994796

Genetic Testing for Choosing a Targeted Therapy for Brain Metastases that Test Positive for Certain Mutations

Genomically-Guided Treatment Trial in Brain Metastases Scientific Title

Purpose
To study the anti-cancer activity of choosing a targeted therapy for brain metastases based on the genetic mutations found in your tumors.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread (metastasized) to your brain with a gene mutation or alteration in: NTRK, ROS1, CDK or PI3K. You must have already received at least one treatment for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups depending on which genetic mutations are found in your tumors: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: CDK-mutation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, twice a day, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: PI3K-mutation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0084, by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: NTRK or ROS1-mutation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Entrectinib (Rozlytrek®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tumor samples from your brain and other parts of your body will be tested for mutations. This is called genomic testing.</li> <li class="seamTextUnorderedListItem">You will be assigned a targeted therapy based on which genetic mutations are found in your tumors.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: NTRK, ROS1, CDK, PI3K</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03994796' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://mbcn.org/brain-mets/' target='_blank'>Metastatic Breast Cancer Network: Brain Mets</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verzenio.com/hcp/patient-profiles' target='_blank'>Eli Lilly & Company Drug Information Page: Verzenio® (Abemaciclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.rozlytrek.com' target='_blank'>Genentech USA Drug Information Page: Rozlytrek (Entrectinib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pi3k-inhibitor-gdc-0084' target='_blank'>NCI Drug Dictionary: GDC-0084</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancernetwork.com/view/targeting-sanctuary-site-options-when-breast-cancer-metastasizes-brain' target='_blank'>Journal Article: Targeting the Sanctuary Site, Options when Breast Cancer Metastasizes to the Brain</a> </li></ul>
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57

NEAREST SITE: 9 miles
Alta Bates Summit Medical Center - Summit Campus
Oakland,CA

VISITS: Coincides with surgery

PHASE: III

NCT ID: NCT03927027

Preventing Lymphedema in Women Having Breast Surgery and a Lymph Node Dissection

ARM: Axillary Reverse Mapping - A Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection With and Without Axillary Reverse Mapping Scientific Title

Purpose
To see if using a surgical technique called Axillary Reverse Mapping during surgery to remove lymph nodes from your underarm area (axillary lymph node dissection) prevents lymphedema.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who have not yet had surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Isosulfan Blue, by injection, during surgery</li> <li class="seamTextUnorderedListItem">Axillary Lymph Node Dissection (ALND)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Isosulfan Blue, by injection, during surgery</li> <li class="seamTextUnorderedListItem">Axillary Lymph Node Dissection (ALND)</li> <li class="seamTextUnorderedListItem">Axillary Reverse Mapping (ARM), during ALND</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that may develop as a side effect of some breast cancer surgeries. </li> <li class="seamTextUnorderedListItem">Lymphedema happens when there is a blockage in your lymphatic system (a part of your immune system) that stops the lymph fluid from draining well. The fluid buildup causes the abnormal swelling. </li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND). This surgery may cause a blockage in your lymphatic system.</li> <li class="seamTextUnorderedListItem">During your ALND, a blue dye will be used to see your lymph nodes and the lymphatic channels that drain your arm. </li> <li class="seamTextUnorderedListItem">Axillary Reverse Mapping (ARM) is when your surgeon tries to avoid disrupting the lymph nodes and lymphatic channels that drain your arm. This may prevent you from developing lymphedema.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03927027' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/lymphedema/symptoms-causes/syc-20374682' target='_blank'>Mayo Clinic: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq' target='_blank'>NCI: Lymphedema (PDQ®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/uploadedFiles/_Komen/Content/About_Breast_Cancer/Tools_and_Resources/Fact_Sheets_and_Breast_Self_Awareness_Cards/AxillaryLymphNodes.pdf' target='_blank'>Susan G. Komen: Axillary Lymph Nodes</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ons.org/node/1531?display=pepnavigator&sort_by=created&items_per_page=50' target='_blank'>Oncology Nursing Society: Axillary Reverse Mapping (ARM)</a> </li><li class='seamTextUnorderedListItem'><a href='https://breast360.org/topic/2017/01/01/axillary-reverse-mapping/' target='_blank'>Breast360.org: Axillary Reverse Mapping</a> </li></ul>
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58

NEAREST SITE: 15 miles
Marin Cancer Care, Inc
Greenbrae,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT04109066

Nivolumab Before and After Surgery For Stage II-III ER+, HER2- Breast Cancer

A Randomized, Multicenter, Double-blind, Placebo-controlled Phase 3 Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Patients With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer Scientific Title

Purpose
To compare the safety, effects (good and bad), and anti-cancer activity of using nivolumab (Opdivo®) before and after surgery in combination with standard of care treatment.
Who is this for?
People with stage II or stage III estrogen receptor-positive (ER+), HER2 negative (HER2-) breast cancer who have not yet started treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <p class="seamTextPara"> Before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV</li> <li class="seamTextUnorderedListItem">Chemotherapy (paclitaxel/Taxol® followed by an anthracycline and cyclophosphamide/Cytoxan®)</li> </ul> <p class="seamTextPara"> After surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV</li> <li class="seamTextUnorderedListItem">Hormone therapy (physician's choice)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard care</i> </p> <p class="seamTextPara"> Before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV</li> <li class="seamTextUnorderedListItem">Chemotherapy (paclitaxel/Taxol® followed by an anthracycline and cyclophosphamide/Cytoxan®)</li> </ul> <p class="seamTextPara"> After surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV</li> <li class="seamTextUnorderedListItem">Hormone therapy (physician's choice)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy drug called a PD-1 inhibitor. It gets the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). </li> <li class="seamTextUnorderedListItem">It is approved to treat certain other types of cancer. </li> <li class="seamTextUnorderedListItem">Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04109066' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/Nivolumab.aspx' target='_blank'>Chemocare: Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youtube.com/watch?reload=9&cid=eb_govdel&v=jDdL2bMQXfE' target='_blank'>NCI: Immunotherapy: How the Immune System Fights Cancer</a> </li></ul>
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59

NEAREST SITE: 22 miles
Contra Costa Regional Medical Center
Martinez,CA

VISITS: Coincides with chemotherapy treatment

PHASE: NA

NCT ID: NCT02728596

CSF to Prevent Neutropenia (Infection) Caused by Chemotherapy (TrACER)

A Pragmatic Trial to Evaluate a Guideline-Based Colony Stimulating Factor Standing Order Intervention and to Determine the Effectiveness of Colony Stimulating Factor Use as a Prophylaxis for Patients Receiving Chemotherapy With Intermediate Risk for Febrile Neutropenia - Trial Assessing CSF Prescribing Effectiveness and Risk (TrACER) Scientific Title

Purpose
To evaluate the benefits of using guidelines that have been developed to direct specific patients who are receiving certain types of chemotherapy to receive CSF to reduce their risk of neutropenia.
Who is this for?
People who are receiving chemotherapy as part of breast cancer treatment and have an intermediate risk of developing neutropenia (a low-white blood cell count).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CSF while receiving chemotherapy treatment </li> <li class="seamTextUnorderedListItem">Quality-of-Life Assessments</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Patients who develop neutropenia--a fever and low white cell blood count--are at increased risk of developing an infection. </li> <li class="seamTextUnorderedListItem">CSF (Colony-stimulating factors) are medications sometimes given to patients receiving chemotherapy to prevent neutropenia. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02728596' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/navigating-cancer-care/side-effects/neutropenia' target='_blank'>Cancer.net: Neutropenia</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/side-effects/fever-neutropenic-fever-and-their-relationship-to-chemotherapy.aspx' target='_blank'>ChemoCare: Fever, Neutropenic Fever, and their Relationship to Chemotherapy</a> </li></ul>
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60

NEAREST SITE: 22 miles
Contra Costa Regional Medical Center
Martinez,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT03418961

Carvedilol to Prevent Heart Problems in Patients with Metastatic HER2+ Breast Cancer

Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients With Metastatic HER-2+ Breast Cancer, Phase III Scientific Title

Purpose
To investigate whether giving people with HER2+ breast cancer a beta-blocker can help prevent heart problems caused by cancer treatments.
Who is this for?
People with HER2 positive metastatic (stage IV) breast cancer who are starting or continuing a trastuzumab-based anitHER2 therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carvedilol, by mouth, daily for up to 2 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No intervention</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: If you are already taking taking a beta blocker, ARB, or ACE inhibitor</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Observation for up to 2 years</li></ul>
  • <p class="seamTextPara"> The beta-blocker being used in this study is carvedilol. It is used to treat heart failure and high blood pressure.</p>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03418961' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/side_effects/heart_probs' target='_blank'>Breastcancer.org: Heart Problems</a> </li></ul>
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61

NEAREST SITE: 25 miles
John Muir Health Clinical Research Center
Concord,CA

VISITS: 2-4 visits per month, for 5 months

PHASE: III

NCT ID: NCT03498716

Tecentriq with Chemotherapy After Surgery for Stage II-III Triple-Negative Breast Cancer

A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti PD-L1 Antibody) in Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone in Patients With Operable Triple Negative Breast Cancer Scientific Title

Purpose
To compare the safety and effects (good and bad) of using an immunotherapy drug along with chemotherapy to chemotherapy alone.
Who is this for?
People, with stage II or stage III triple negative (ER-, PR- and HER2-) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Chemotherapy with Atezolizumab</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 2 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 months</li> <li class="seamTextUnorderedListItem">followed by Tecentriq and dose-dense chemotherapy (physician's choice), by IV, every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">Sargramostim or filgrastim</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Chemotherapy alone </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 months</li> <li class="seamTextUnorderedListItem">Followed by dose-dense chemotherapy (physician's choice), every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">Sargramostim or filgrastim</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tatezolizumab (Tecentriq®) is the immunotherapy drug used in this study. It gets the immune system to attack cancer cells by blocking a protein called PD-L1 (programmed death-ligand 1). </li> <li class="seamTextUnorderedListItem">Tatezolizumab is used to treat some triple negative (ER-, PR-, HER2-) breast cancers and some lung and bladder cancers. </li> <li class="seamTextUnorderedListItem">Your first chemotherapy drug will be paclitaxel (Taxol). It will be followed by dose-dense chemotherapy. </li> <li class="seamTextUnorderedListItem">Your doctor will decide if you receive doxorubicin (Adriamycin®) or epirubicin (Ellence®) and cyclophosphamide (Cytoxan®). </li> <li class="seamTextUnorderedListItem">You will also receive GM-CSF (sargramostim) or G-CSF (filgrastim) to prevent neutropenia--a low white blood cell count that increases your risk for infection.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03498716' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/media/product-information/tecentriq' target='_blank'>Genentech: Tecentriq</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/symptoms/neutropenia/basics/definition/sym-20050854' target='_blank'>Mayo Clinic: Neutropenia</a> </li></ul>
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62

NEAREST SITE: 27 miles
Stanford University Hospitals and Clinics
Stanford,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02401347

Talazoparib for Advanced HER2 Negative Breast Cancer with Certain Mutations

A Phase II Clinical Trial of BMN 673 in BRCA1 and BRCA2 Wild-Type Patients With (i) Advanced Triple-Negative Breast Cancer and Homologous Recombination Deficiency as Assessed by the HRD Assay, and (ii) Advanced HER2-Negative Breast Cancer With Either a Germline or Somatic Mutation in... Scientific Title

Purpose
To study the safety and anti-cancer activity of the PARP inhibitor talazoparib (Talzenna®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that is HER2 negative (HER2-) and who have received at least one prior chemotherapy for metastatic disease. Your tumor must test positive for or express one of several markers. (See below for a list of targets and mutations.) You cannot enroll in this trial if you have an inherited BRCA 1 or BRCA 2 mutation.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®) is a PARP inhibitor that is approved to treat people with advanced or metastatic HER2 negative (HER2-) breast cancer and an inherited BRCA 1 or BRCA 2 mutation. </li> <li class="seamTextUnorderedListItem">You cannot enroll in this trial If you have an inherited BRCA 1 or BRCA 2 mutation.</li> <li class="seamTextUnorderedListItem">Targets or mutations: Homologous Recombination Deficiency, PTEN, PALB2, CHEK2, ATM, NBN, BARD1, BRIP1, RAD50, Rad51c, Rad51d, MRE11, ATR, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, plus other HR-related genes at the discretion of the primary investigators.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02401347' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/EmergingMetasticBreastCancer.html' target='_blank'>Susan G. Komen: Emerging Areas in Metastatic Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.talzenna.com' target='_blank'>Pfizer Oncology Information Page: Talazoparib</a> </li></ul>
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63

NEAREST SITE: 27 miles
Stanford University School of Medicine
Stanford,CA

VISITS: 1 visit

PHASE: NA

NCT ID: NCT01034033

How Cancer Develops in Women With BRCA1/2 or Other Genetic Mutations

Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples Scientific Title

Purpose
To analyze blood samples from women at high risk of developing breast cancer in order to learn more about how cells change over time from normal to cancerous
Who is this for?
Women at high-risk for developing breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will provide blood samples.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BRCA 1 and BRCA 2 are tumor suppressor genes.</li> <li class="seamTextUnorderedListItem">Inheriting a mutation in the BRCA 1 or BRCA 2 gene increases cancer risk.</li> <li class="seamTextUnorderedListItem">For the cancer to develop, though, the cells will need to first acquire other mutations.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01034033' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://stanfordhealthcare.org/medical-conditions/cancer/hboc/brca-1-and-2.html' target='_blank'>Stanford Health Care: BRCA1 and BRCA2 Genes</a> </li><li class='seamTextUnorderedListItem'><a href='https://brightpink.org' target='_blank'>Bright Pink: Breast and Ovarian Health Organization</a> </li></ul>
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64

NEAREST SITE: 27 miles
Stanford University /ID# 206949
Stanford,CA

VISITS: 1 visit every 2 or 4 weeks, ongoing

PHASE: I

NCT ID: NCT03071757

ABBV-36 and ABBV-181 in Advanced Triple Negative Breast (and other) Cancers

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To study the safety and best dose of the investigational drug ABBV-368 when it is given with or without the investigational drug ABBV-181.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer and have already had a treatment that your cancer did not respond to or has stopped responding to.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-368, by IV, every 2 or 4 weeks, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-368, by IV, every 4 weeks, ongoing</li> <li class="seamTextUnorderedListItem">ABBV-181, by IV</li> <li class="seamTextUnorderedListItem">18F PET scan</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-368 is an anti-OX40 monoclonal antibody that targets a protein found on some T cells. By targeting these proteins, the researchers think the drug will help other T cells kill cancer cells. </li> <li class="seamTextUnorderedListItem">ABBV-181 is a new type of PD-1 inhibitor. These are immunotherapy drugs that get the immune system to kill cancer cells by blocking PD-1. </li> <li class="seamTextUnorderedListItem">The study will also see if a new type of PET scan dye can help researchers see whether the drugs are activating an immune response. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03071757' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.abbvie.com/our-science/pipeline/abbv-368.html' target='_blank'>Drug Company Information Page: ABBV-368</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/targeted-cancer-drugs/types/monoclonal-antibodies' target='_blank'>Cancer Research UK: Monoclonal Antibodies</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/abbv-181/' target='_blank'>Immuno-Oncology News: ABBV-181</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/792559' target='_blank'>NCI Drug Dictionary: ABBV-368</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.6050' target='_blank'>ASCO Abstract: Novel PET imaging with [18F]F-AraG</a> </li></ul>
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65

NEAREST SITE: 27 miles
Exelixis Clinical Site #21
Stanford,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03170960

Cabozantinib Alone or With Atezolizumab in Advanced Triple Negative Breast Cancer

A Phase 1b Dose-Escalation Study of Cabozantinib (XL184) Administered Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To assess the safety, best dose, and effects (good and bad) of cabozantinib (Cabometyx®) when it is used alone or with atezolizumab (Tecentriq®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) that has already been treated with at least one line of therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, once every 3 weeks</li> <li class="seamTextUnorderedListItem">Cabozantinib (Cabometyx®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cabometyx is a targeted therapy that blocks some of the signals that tell cancer cells to grow and divide and that stimulate the blood vessels the cancer cells need grow. It is approved to treat kidney and liver cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Tecentriq is a type of immunotherapy called an immune checkpoint inhibitor. It is approved for use in combination with the chemotherapy drug Abraxane® (nab-paclitaxel) to treat advanced triple-negative, PD-L1-positive breast cancer. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03170960' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a616037.html' target='_blank'>Medlineplus: Cabozantinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.1026' target='_blank'>ASCOPubs.org: A phase II study of cabozantinib alone or in combination with trastuzumab in patients with breast cancer brain metastases</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2019/atezolizumab-triple-negative-breast-cancer-fda-approval' target='_blank'>NCI: Atezolizumab Approved for Some Patients with TNBC</a> </li></ul>
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66

NEAREST SITE: 27 miles
Stanford Women Cancer Center
Stanford,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03455270

G1T48 for Advanced ER+ HER2- Breast Cancer

A Phase 1, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of Ascending Doses of G1T48 in Women With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of the experimental hormonal therapy G1T48.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) advanced breast cancer who have already received an aromatase inhibitor.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">G1T48 (oral SERD), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">G1T48 is type of hormone therapy called a selective estrogen receptor degrader (SERD).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03455270' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.g1therapeutics.com/pages/pipeline/G1T48.htm' target='_blank'>Drug Company Information Page: G1T48</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.g1therapeutics.com/pipeline/g1t48/' target='_blank'>Drug Company Information Page #2: G1T48</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/77/13_Supplement/5641' target='_blank'>AACR Publication: Effects of G1T48</a> </li></ul>
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67

NEAREST SITE: 27 miles
Stanford Cancer Center ( Site 0072)
Palo Alto,CA

VISITS: Weekly visits for 1 month, then 1 visit every 3 weeks for 1 year

PHASE: III

NCT ID: NCT03725059

Chemotherapy & Endocrine Therapy With or Without Pembrolizumab in Stage I-III ER Positive, HER2 Negative Breast Cancer

A Randomized, Double-Blind, Phase III Study of Pembrolizumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy for the Treatment of High-Risk Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (KEYNOTE-756) Scientific Title

Purpose
To compare the anti-cancer activity of giving the immunotherapy pembrolizumab (Keytruda®) before and after surgery in combination with the standard of care chemotherapy and hormone therapy to just the standard of care chemotherapy and hormone therapy.
Who is this for?
People with stage I, stage II, or stage III estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Pembrolizumab plus standard of care</i> </p> <p class="seamTextPara"> Before surgery and radiation therapy </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab, by IV, every 3 weeks, for 6 months</li> <li class="seamTextUnorderedListItem">Paclitaxel, by IV, weekly, for 1 month <i class="seamTextEmphasis">followed by</i></li> <li class="seamTextUnorderedListItem">Doxorubicin or epirubicin and cyclophosphamide, by IV, every 3 weeks, for 5 months</li> </ul> <p class="seamTextPara"> After surgery and radiation therapy </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab, by IV, every 3 weeks, for 7 months</li> <li class="seamTextUnorderedListItem">Hormone therapy, by mouth, daily, for 10 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Placebo plus standard of care</i> </p> <p class="seamTextPara"> Before surgery and radiation therapy </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV, every 3 weeks, for 6 months</li> <li class="seamTextUnorderedListItem">Paclitaxel, by IV, weekly, for 1 month <i class="seamTextEmphasis">followed by</i></li> <li class="seamTextUnorderedListItem">Doxorubicin or epirubicin and cyclophosphamide, by IV, every 3 weeks, for 5 months</li> </ul> <p class="seamTextPara"> After surgery and radiation therapy </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV, every 3 weeks, for 7 months</li> <li class="seamTextUnorderedListItem">Hormone therapy, by mouth, daily, for 10 years</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03725059' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://keynoteclinicaltrials.com/trials/breast-cancer' target='_blank'>Keynote Trials: Investigational Immunotherapy Trials for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertherapyadvisor.com/gastrointestinal-cancers/cervical-cancer-pembrolizumab-fda-approval-treatment/article/773440/' target='_blank'>Cancer Therapy Advisor: Pembrolizumab FDA-Approved for the Treatment of Advanced Cervical Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm560167.htm' target='_blank'>FDA: FDA approves first cancer treatment for any solid tumor with a specific genetic feature</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healio.com/hematology-oncology/breast-cancer/news/online/%7Bf4b314b6-7cb8-470f-ae44-0cddfe7762e7%7D/addition-of-pembrolizumab-to-chemotherapy-demonstrates-promise-in-triple-negative-breast-cancer' target='_blank'>HemOncToday: Addition of pembrolizumab to chemotherapy demonstrates promise in triple-negative breast cancer</a> </li></ul>
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68

NEAREST SITE: 27 miles
Stanford Cancer Center
Stanford,CA

VISITS: 3 visits a month, ongoing

PHASE: III

NCT ID: NCT04177108

Paclitaxel Alone or With Ipatasertib and/or Atezolizumab for People with Advanced TNBC

A Phase III, Double-blind, Placebo-controlled, Randomized Study Of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer. Scientific Title

Purpose
To look at at the safety and effects (good and bad) of the experimental targeted therapy ipatasertib (GDC-0068) when it is used along with the chemotherapy drug paclitaxel (Taxol®) and the immunotherapy atezolizumab (Tecentriq®).
Who is this for?
People who are starting treatment for advanced (some stage III) or metastatic (stage IV) triple negative breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> If your tumor is negative for PD-L1, you will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> If your tumor is positive for PD-L1, you will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib is a type of targeted therapy called an AKT inhibitor. AKT is a protein that helps cancers grow.</li> <li class="seamTextUnorderedListItem">Tecentriq® is a type of immunotherapy called a PD-L1 (programmed death-ligand 1) inhibitor. It is approved for use along with Taxol to treat metastatic triple negative breast cancer that tests positive for PD-L1.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04177108' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://blog.dana-farber.org/insight/2017/05/what-is-a-pd-l1-test/' target='_blank'>Dana-Farber Cancer Institute: What is PD-L1?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2019/atezolizumab-triple-negative-breast-cancer-fda-approval' target='_blank'>NCI Cancer Currents Blog: Atezolizumab Approved for Some Patients with Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biooncology.com/pipeline-molecules/ipatasertib.html' target='_blank'>Genentech Information Page: Ipatasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/taxol-better-than-ixempra-or-abraxane' target='_blank'>Breastcancer.org: Study Confirms Taxol Better Than Ixempra or Abraxane for Locally Advanced or Metastatic Disease</a> </li></ul>
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69

NEAREST SITE: 28 miles
Kaiser Permanente - Northern California
Vallejo,CA

VISITS: Please contact research site

PHASE: NA

NCT ID: NCT03061305

Molecular Profiling to Select Treatment for Advanced Breast Cancer

Profiling Biospecimens From Cancer Patients to Screen for Molecular Alterations Related to Treatment Selection (STRATA) Scientific Title

Purpose
To conduct a test of your tumor to determine if there are approved therapies or clinical trials targeting the mutations or biomarkers found in your tumor.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Molecular profiling will be done on your tumor sample at no cost.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A sample of your tumor will be tested for certain mutations and biomarkers. </li> <li class="seamTextUnorderedListItem">Your doctor will be told if there are treatments or clinical trials available for people with the mutations or biomarkers found in your tumor. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling patients with other types of cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: EGFR, BRAF, ERBB2 (HER2), and ALK</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03061305' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/testing/types/broad-molecular-profiling-tests' target='_blank'>Breastcancer.org: Broad Molecular Profiling Tests</a> </li><li class='seamTextUnorderedListItem'><a href='https://unclineberger.org/research/octr/our-research/strata-trial' target='_blank'>UNC Lineberger Comprehensive Cancer Center: Study website</a> </li></ul>
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70

NEAREST SITE: 28 miles
Stanford Cancer Center
Stanford,CA

VISITS: At least 1 visit every 2 months for the first year, then every 3 months thereafter

PHASE: I-II

NCT ID: NCT03215511

LOXO-195 for Advanced Breast Cancer with a NTRK Mutation

A Phase 1/ 2 Study of the TRK Inhibitor LOXO 195 in Adult Subjects With NTRK Fusion (Previously Treated) or Non-Fusion NTRK Altered Cancers Scientific Title

Purpose
To test the safety and effects (good and bad) of LOXO-195.
Who is this for?
People with locally advanced (stage III) or metastatic (stage IV) breast cancer that has an NTRK mutation. You must have no other standard treatment options available and have previously received a TRK inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LOXO-195, by mouth</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LOXO-195 is an investigational drug. </li> <li class="seamTextUnorderedListItem">It is a tyrosine-kinase inhibitor that binds to the TRK protein. </li> <li class="seamTextUnorderedListItem">Researchers believe it can stop cancer cell growth in tumors with an NTRK mutation.</li> <li class="seamTextUnorderedListItem">Targets or mutations: NTRK</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03215511' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/trk-inhibitor-loxo-195' target='_blank'>NCI Dictionary: LOXO-195</a> </li></ul>
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71

NEAREST SITE: 28 miles
Stanford University, School of Medicine
Palo Alto,CA

VISITS: 1 visit every 3 weeks for 1.5 years

PHASE: I

NCT ID: NCT03364348

PF-05082566 With Kadcyla® or Trastuzumab For Advanced HER2 Positive Breast Cancer

A Phase 1B Dose Escalation Trial of Human Anti-4-1BB Agonistic Antibody PF-05082566 in Combination With Adotrastuzumab-Emtansine or Trastuzumab in Patients With HER2-Positive Advanced Breast Cancer Scientific Title

Purpose
To look at the safety and effects (good and bad) of using utomilumab (PF-05082566) with trastuzumab emtansine (Kadcyla®) or trastuzumab (Herceptin).
Who is this for?
People with HER2 positive advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab Emtansine (Kadcyla®), by IV, every 3 weeks </li> <li class="seamTextUnorderedListItem">Utomilumab (PF-05082566), by IV, every 3 weeks </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks </li> <li class="seamTextUnorderedListItem">Utomilumab (PF-05082566), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Utomilumab is an investigational immunotherapy that targets 4-1BB (CD-137), a molecule that stimulates the immune system. </li> <li class="seamTextUnorderedListItem">Herceptin is a HER2-targeted therapy approved to treat HER2 positive breast cancer. </li> <li class="seamTextUnorderedListItem">Kadcyla is an antibody-drug conjugate (ADC). It uses Herceptin to deliver the chemotherapy drug DM1 directly to the cancer cells. It is approved to treat HER2 positive metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03364348' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/utomilumab/' target='_blank'>Immuno-oncology News: Utomilumab</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.hematologyandoncology.net/archives/april-2017/antibody-drug-conjugates-in-breast-cancer/' target='_blank'>Clinical Advances in Hematology & Oncology: ADC in Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.roche.com/media/releases/med-cor-2013-02-22.htm' target='_blank'>Roche: Kadcyla® Approval</a> </li></ul>
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72

NEAREST SITE: 28 miles
Stanford Cancer Center
Palo Alto,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I

NCT ID: NCT03621982

ADCT-301 in Advanced Triple Negative Breast Cancer

A Phase 1b, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of Camidanlumab Tesirine (ADCT-301) in Patients With Selected Advanced Solid Tumors Scientific Title

Purpose
To compare the safety and effects (good and bad) of ADCT-301, a targeted therapy that combines the monoclonal antibody HuMax-TAC with a new type of chemotherapy drug called PBD.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that has not responded to other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ADCT-301, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ADCT-301 is a new type of targeted therapy that combines the monoclonal antibody HuMax-TAC with a new type of chemotherapy drug called PBD. </li> <li class="seamTextUnorderedListItem">The monoclonal antibody brings the chemotherapy directly to the cancer cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03621982' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://adcreview.com/editorial/adct-301-a-novel-antibody-drug-conjugate-against-lymphomas-moves-into-phase-i-clinical-trial/' target='_blank'>ADC Review: ADCT-301</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/2019/02/05/phase-1b-trial-of-adct-301-in-advanced-solid-tumors-dosed-first-patient/' target='_blank'>Immuno-Oncology News: ADCT-301</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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73

NEAREST SITE: 28 miles
Stanford University Medical Center
Palo Alto,CA

VISITS: Coincides with surgery

PHASE: III

NCT ID: NCT03686215

Detection of Residual Cancer Cells During Breast Cancer Surgery

Pivotal Study of the LUM Imaging System for Assisting Intraoperative Detection of Residual Cancer in the Tumor Bed of Female Patients With Breast Cancer Scientific Title

Purpose
To test the safety and effectiveness of using the LUM Imaging System during breast surgery to identify cancer cells.
Who is this for?
Women who will be having surgery to treat DCIS or stage I, II or III breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LUM015, by IV, 2 to 6 hours prior to surgery</li> <li class="seamTextUnorderedListItem">LUM imaging to guide additional tissue removal, during surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LUM015, by IV, 2 to 6 hours prior to surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The LUM Imaging System uses a dye, called LUM015, injected prior to surgery. </li> <li class="seamTextUnorderedListItem">The dye attaches to cancer cells in breast tissue. </li> <li class="seamTextUnorderedListItem">This can help the surgeon determine if cancer cells remain in the tumor bed after the DCIS or primary tumor has been removed.</li> <li class="seamTextUnorderedListItem">If the imaging identifies that there may be cancer cells remaining, the surgeon will remove an additional piece of tissue. This process will be continued until a negative reading from the device is obtained.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03686215' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.lumicell.com/' target='_blank'>Sponsor site: Lumicell</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/13_Supplement/CT166' target='_blank'>Cancer Research Abstract: LUM Imaging System</a> </li></ul>
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74

NEAREST SITE: 28 miles
Stanford University School of Medicine
Palo Alto,CA

VISITS: 1 visit every 2 weeks, ongoing

PHASE: I

NCT ID: NCT03821233

ZW49 in Patients With Advanced HER2-Positive Breast Cancer

A Phase 1 Study of ZW49 in Patients With Locally Advanced (Unresectable) or Metastatic HER2-Expressing Cancers Scientific Title

Purpose
To evaluate the safety, effects (good and bad), and best dose of a new targeted therapy called ZW49.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZW49, by IV, every 2 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZW49 uses an antibody that can attach to HER2 proteins to deliver chemotherapy directly to the cancer cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of HER2 positive tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03821233' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.zymeworks.com/our-pipeline/zw49' target='_blank'>Drug Company Study Information: ZW49</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/13_Supplement/3914' target='_blank'>AACR Journal Abstract: ZW49, A HER2-Targeted Biparatopic Antibody-Drug Conjugate for the Treatment of HER2-expressing Cancers</a> </li></ul>
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75

NEAREST SITE: 28 miles
Stanford University
Stanford,CA

VISITS: Daily visits for 5 days, followed by surgery

PHASE: NA

NCT ID: NCT03909282

Radiation Therapy Before Surgery For DCIS

A Randomized Phase II Study Comparing Surgical Excision Versus Neoadjuvant Radiotherapy Followed by Delayed Surgical Excision of Ductal Carcinoma In Situ (NORDIS) Scientific Title

Purpose
To look at the effect radiation therapy has on DCIS cancer cells and surrounding tissue when it is given before surgery.
Who is this for?
Women with ductal carcinoma in situ (DCIS) who has not yet started cancer treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Partial breast irradiation, once a day for 5 days, before surgery</li> <li class="seamTextUnorderedListItem">Lumpectomy or mastectomy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lumpectomy or mastectomy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is looking at the effect radiation therapy has on DCIS cancer cells and surrounding tissue when it is given before surgery.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03909282' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/types/dcis/treatment?gclid=EAIaIQobChMIyOnukvrn5QIVoxx9Ch1_pgdEEAAYAiAAEgIxZvD_BwE' target='_blank'>Breastcancer.org: Treatment for DCIS</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/rads-after-sx-for-dcis-reduces-recurrence-risk' target='_blank'>Breastcancer.org: Radiation Therapy After Surgery for Low-Risk DCIS Reduces Recurrence Risk</a> </li></ul>
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76

NEAREST SITE: 53 miles
St. Joseph Heritage Healthcare
Santa Rosa,CA

VISITS: 1 visit every 3 weeks, for 2 years

PHASE: I-II

NCT ID: NCT03761914

Immunotherapy Galinpepimut-S and Pembrolizumab for Advanced Triple Negative Breast Cancer

A Phase 1/2 Study of Galinpepimut-S in Combination With Pembrolizumab (MK 3475) in Patients With Selected Advanced Cancers Scientific Title

Purpose
To assess the safety, effects (good and bad) and best dose of the immunotherapy galinpepimut-S when it is used along with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer that has not responded to other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be given the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GM-CSF, by injection, before Galinpepimut-S</li> <li class="seamTextUnorderedListItem">Galinpepimut-S, by injection, every 3 weeks, for up to 2 years</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, for 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Galinpepimut-S is a vaccine that targets the protein WT1. </li> <li class="seamTextUnorderedListItem">Higher than normal amounts of this protein are found on the surface of breast and certain other cancer cells. </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03761914' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sellaslifesciences.com/galinpepimut-s-gps-therapy/' target='_blank'>Trial Sponsor Sellas Lifescience: Galinpepimut-S Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/galinpepimut-s/' target='_blank'>Immuno-Oncology News: Galinpepimut-S</a> </li><li class='seamTextUnorderedListItem'><a href='https://pharmaphorum.com/views-and-analysis/asco-2017-breast-cancer-keytruda/' target='_blank'>Pharmaphorum: ASCO 2017: Breast cancer next target for Keytruda</a> </li></ul>
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77

NEAREST SITE: 72 miles
Investigational Site Number 8400019
Woodland,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT04059484

SAR439859 for Advanced ER+ Breast Cancer in Postmenopausal Women

An Open Label Randomized Phase 2 Trial of SAR439859, Versus Endocrine Monotherapy as Per Physician's Choice in Premenopausal and Postmenopausal Patients With Estrogen Receptor-positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer With Prior Exposure to Hormonal Therapies Scientific Title

Purpose
To compare the anti-cancer activity and side effects of the experimental anti-estrogen drug SAR439859 with anti-estrogen drugs already approved and commonly used.
Who is this for?
Postmenopausal women with advanced (some stage III) or metastatic (stage IV) estrogen-receptor positive (ER+), HER2 negative (HER2-) breast cancer treated who have received no more than one chemotherapy or targeted therapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SAR439859, by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doctor's choice of anti-estrogen therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SAR439859 is a type of anti-estrogen drug called a selective estrogen receptor degrader, or SERD.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04059484' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793484' target='_blank'>NCI Drug Dictionary: SAR439859</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/HormoneTherapies.html' target='_blank'>Susan G. Komen: Hormone Therapies for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Selective_estrogen_receptor_degrader' target='_blank'>Wikipedia: SERD</a> </li><li class='seamTextUnorderedListItem'><a href='https://cancerres.aacrjournals.org/content/78/13_Supplement/943' target='_blank'>Journal Abstract: SAR439859</a> </li><li class='seamTextUnorderedListItem'><a href='https://jhoonline.biomedcentral.com/articles/10.1186/s13045-018-0620-6' target='_blank'>Journal Article: Overcoming Endocrine Resistance in Metastatic Hormone Receptor-positive Breast Cancer</a> </li></ul>
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78

NEAREST SITE: 74 miles
University of California Davis Comprehensive Cancer Center
Sacramento,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02498613

Cediranib and Lynparza for Metastatic Triple Negative Breast Cancer

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors Scientific Title

Purpose
To study the effects (good and bad) and the anti-cancer activity of combining the PARP inhibitor olaparib (Lynparza®) with the targeted therapy cediranib.
Who is this for?
People with advanced (stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer. You must have received one prior therapy for your cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cediranib, by mouth, daily</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of targeted therapy called a PARP inhibitor. </li> <li class="seamTextUnorderedListItem">Cediranib is a type of drug called an angiogenesis inhibitor. </li> <li class="seamTextUnorderedListItem">Giving cediranib with olaparib may make the olaparib more effective.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02498613' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medscape.com/viewarticle/891245' target='_blank'>Medscape: Olaparib</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Cediranib' target='_blank'>Wikipedia: Cediranib</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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79

NEAREST SITE: 74 miles
UC Davis Medical Center
Sacramento,CA

VISITS: At least 3 visits

PHASE: NA

NCT ID: NCT02366806

Individualized Radiotherapy Education for Patients with Early-Stage Breast Cancer

Impact of Individualized Radiotherapy Plan Review in Patients Receiving Adjuvant Radiotherapy for Breast Cancer Scientific Title

Purpose
To compare the benefits of a standard radiation education plan to a personalized radiation education plan.
Who is this for?
Women who are scheduled to receive radiation therapy for stage I, stage II, or stage III breast cancer at the University of California, Davis.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard education about treatment plan</li> <li class="seamTextUnorderedListItem">3 quality of life questionnaires during treatment</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">In-depth education about treatment plan</li> <li class="seamTextUnorderedListItem">3 quality of life questionnaires during treatment</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The standard of care for treating early-stage breast cancer is a lumpectomy followed by radiation. </li> <li class="seamTextUnorderedListItem">Prior to starting radiation, patients typically receive general information about radiation therapy and its potential side effects. </li> <li class="seamTextUnorderedListItem">An in-depth, personalized treatment education plan may be more beneficial.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02366806' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation' target='_blank'>BreastCancer.org: Radiation Therapy</a> </li></ul>
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80

NEAREST SITE: 74 miles
University of California Davis Comprehensive Cancer Center
Sacramento,CA

VISITS: 1 visit every 3 weeks

PHASE: II

NCT ID: NCT02849496

Olaparib Alone or With Atezolizumab for People With Advanced HER2 Negative Breast Cancer & an Inherited BRCA1/2 Mutation

A Phase II Multiple-Arm, Open-Label, Randomized Study of PARP Inhibition (Veliparib; ABT-888) and Anti-PD-L1 Therapy (Atezolizumab; MPDL3280A) Either Alone or in Combination in Homologous DNA Repair (HDR) Deficient Triple Negative Breast Cancer (TNBC) Scientific Title

Purpose
To compare the anti-cancer activity of the targeted therapy olaparib (Lynparza®) when it is given alone to when it is given in combination with the immunotherapy atezolizumab (Tecentriq®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative breast cancer who have an inherited BRCA 1 or BRCA 2 mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily, ongoing</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsies</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of targeted therapy called a PARP inhibitor. PARP inhibitors work by blocking the action of poly (ADP-ribose) polymerase, an enzyme that helps repair DNA.</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is approved to treat HER2 negative (HER2-) metastatic breast cancer in women with a BRCA 1/2 genetic mutation.</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is a type of immunotherapy called a PD-LI inhibitor. It works by getting the immune system to go after cancer cells by blocking a protein called PD-L1 (programmed death ligand-1). </li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is approved for use in advanced triple negative breast cancer. Its use in this trial is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02849496' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparza.com' target='_blank'>AstraZeneca Drug Information Page: Lynparza® (Olaparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/parp-inhibitors-in-breast-cancer-treatment' target='_blank'>Breast Cancer Now: PARP Inhibitors in Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tecentriq.com' target='_blank'>Genentech Drug Information Page: Tecentriq® (Atezolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li></ul>
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81

NEAREST SITE: 74 miles
UC Davis Medical Center, Investigational Drug Service
Sacramento,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT03778931

Elacestrant in Advanced ER+, HER2- Breast Cancer (EMERALD)

Elacestrant Monotherapy vs. Standard of Care for the Treatment of Patients With ER+/HER2- Advanced Breast Cancer Following CDK4/6 Inhibitor Therapy: A Phase 3 Randomized, Open-label, Active-controlled, Multicenter Trial Scientific Title

Purpose
To compare the effectiveness of elacestrant to fulvestrant (Faslodex®) and aromatase inhibitors.
Who is this for?
People with locally advanced (some stage III) or metastatic (stage IV), estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer. You must have already been treated with a CDK4/6 inhibitor in combination with fulvestrant (Faslodex®) or an aromatase inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Elacestrant, by mouth, daily, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy chosen by your doctor: Anastrozole (Armidex®), Letrozole (Femara®), Exemestane (Aromasin®), or Fulvestrant (Faslodex®)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Elacestrant is an investigational hormone therapy. </li> <li class="seamTextUnorderedListItem">It is expected to work in a similar way as fulvestrant (Faslodex®), but is given by mouth, once a day, instead of by injection, once a month. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) and aromatase inhibitors are commonly used to treat metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: ESR1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03778931' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healio.com/hematology-oncology/breast-cancer/news/online/%7B33085c45-4dcc-46b9-8083-f211dfd03ff5%7D/fda-grants-fast-track-designation-to-elacestrant-for-breast-cancer-subtype' target='_blank'>Healio: FDA grants fast track designation to elacestrant for breast cancer subtype</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/4_Supplement/P4-04-17#' target='_blank'>AACR: Elacestrant (RAD1901) demonstrates anti-tumor activity in a fulvestrant-resistant PDX model</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biospace.com/article/radius-health-cmo-has-hope-for-breast-cancer-assets-elacestrant-and-rad140/' target='_blank'>BioSpace: Radius Health CMO Has Hope for Breast Cancer Assets Elacestrant and RAD140</a> </li></ul>
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82

NEAREST SITE: 74 miles
University of California Davis Comprehensive Cancer Center ( Site 0005)
Sacramento,CA

VISITS: 1 visit every 3 weeks, for 2 years

PHASE: II

NCT ID: NCT03797326

Pembrolizumab with Lenvatinib in Previously Treated Advanced Triple Negative Breast Cancer

A Multicenter, Open-label Phase 2 Study of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) in Previously Treated Subjects With Selected Solid Tumors (LEAP-005) Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using pembrolizumab (Keytruda®) along with lenvatinib (Lenvima®).
Who is this for?
People with triple negative (ER-, PR-, HER2-) advanced (some stage III) or metastatic (stage IV) breast cancer who have already had one or two treatment regimens.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, for 2 years </li> <li class="seamTextUnorderedListItem">Lenvatinib (Lenvima®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">It stimulates the body's immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">It is approved to treat certain types of cancers, but its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Lenvima is a targeted therapy that blocks vascular endothelial growth factor receptor 2 (VEGFR2). </li> <li class="seamTextUnorderedListItem">It is approved for treating patients with certain types of thyroid, kidney and liver cancers. </li> <li class="seamTextUnorderedListItem">Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study will also include people with other types of cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03797326' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/pembrolizumab' target='_blank'>NCI drug dictionary: Pembrolizumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/lenvatinibmesylate' target='_blank'>NCI drug dictionary: Lenvatinib</a> </li></ul>
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83

NEAREST SITE: 74 miles
University of California Davis
Sacramento,CA

VISITS: 1 visit every 3 weeks

PHASE: III

NCT ID: NCT03975647

T-DM1 and Tucatinib for Advanced HER2+ Breast Cancer

Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Subjects With Unresectable Locally-advanced or Metastatic HER2+ Breast Cancer Scientific Title

Purpose
To compare the effects (good and bad) of tucatinib (Tukysa) and T-DM1 to T-DM1 and a placebo.
Who is this for?
Women with locally advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+) breast cancer who have previously been treated with a taxane and trastuzumab (Herceptin®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa), by mouth, twice daily </li> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®), by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, twice daily </li> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa) is a HER2-targeted therapy approved for use with certain other therapies. Its use in this trial is considered experimental. </li> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®) is an antibody-drug conjugate (ADC). It uses an antibody—the HER2-targeted therapy trastuzumab (Herceptin®)—to deliver the chemotherapy drug DM1 directly to the cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03975647' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tukysahcp.com' target='_blank'>Seattle Genetics Information Page: Tukysa (Tucatinib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/kadcyla' target='_blank'>Breastcancer.org: Kadcyla® (T-DM1)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/publications/oncology-live/2018/vol-19-no-24/tucatinib-shows-promise-in-patients-with-breast-cancer-and-brain-metastases' target='_blank'>OncLive: Tucatinib Shows Promise in Patients With Breast Cancer and Brain Metastases</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancernetwork.com/news/tucatinib-shows-promise-phase-i-study-her2-positive-breast-cancer' target='_blank'>CancerNetwork:Tucatinib Shows Promise in Phase I Study of HER2-Positive Breast Cancer</a> </li></ul>
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84

NEAREST SITE: 86 miles
Pacific Cancer Care
Monterey,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT03523585

Trastuzumab Deruxtican (DS-8201a) Versus Standard of Care for Advanced HER2 Positive Breast Cancer

A Phase 3, Multicenter, Randomized, Open-label, Active-controlled Study of DS-8201a, an Anti-HER2-antibody Drug Conjugate, Versus Treatment of Investigator's Choice for HER2-positive, Unresectable and/or Metastatic Breast Cancer Subjects Pretreated With Prior Standard of Care HER2 Therapies, Including T DM1 [DESTINY-Breast02] Scientific Title

Purpose
To compare the effects (good and bad) of the HER2 targeted therapy trastuzumab deruxtican (DS-8201a) to the standard of care in patients with advanced breast cancer who have already received the HER2 targeted therapy Kadcyla.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive breast cancer who have already received T-DM1 (Kadcyla®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab deruxtican (DS-8201a), by IV (please contact research site for treatment schedule)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, 2 times per day</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, 2 times per day</li> <li class="seamTextUnorderedListItem">Lapatinib (Tykerb®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DS-8201a (Trastuzumab deruxtecan) is an experimental HER2-targeted therapy, it is also an antibody-drug conjugate (ADC).</li> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®) is an antibody-drug conjugate (ADC).</li> <li class="seamTextUnorderedListItem">ADC uses an antibody—the HER2-targeted therapy trastuzumab (Herceptin®)—to deliver the chemotherapy drug directly to the cancer cells.</li> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®) is approved to treat HER2-positive metastatic breast cancer that has previously been treated with Herceptin and a taxane chemotherapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03523585' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-grants-ds8201-breakthrough-designation-for-her2-breast-cancer' target='_blank'>OncLive: FDA Grants DS-8201 Breakthrough Designation for HER2+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://adcreview.com/news/updated-analysis-ongoing-phase-trial-ds-8201-confirms-significant-benefit-her2-breast-cancer-patients-pretreated-ado-trastuzumab-emtansine/' target='_blank'>ADC Review: Trial Update of DS-8201</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/issues/april-10-2018/potent-anti-her2-agents-on-the-horizon/' target='_blank'>ASCO: Potent Anti-HER2 Agents</a> </li><li class='seamTextUnorderedListItem'><a href='https://adcreview.com/adc-university/adcs-101/antibody-drug-conjugates-adcs/' target='_blank'>ADC Review: What Are Antibody-Drug Conjugates?</a> </li></ul>
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85

NEAREST SITE: 86 miles
Pacific Cancer Care
Monterey,CA

VISITS: 3 visits per month, ongoing

PHASE: II

NCT ID: NCT03961698

IPI-549, Tecentriq® and Abraxane® for Advanced Triple-Negative Breast Cancer

A Phase 2, Multi-arm, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of IPI-549 Administered in Combination With Front-line Treatment Regimens in Patients With Locally Advanced and/or Metastatic Triple-Negative Breast Cancer or Renal Cell Carcinoma Scientific Title

Purpose
To study the effects of IP-549 when it is used with atezolizumab (Tecentriq®) and paclitaxel (Abraxane®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple-negative (ER-,PR-,HER2-) breast cancer that has not been treated with chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">IPI-549, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 2 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, weekly, 3 weeks on, 1 week off, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">IP-549 is a type of experimental targeted therapy called a PI3K-gamma inhibitor. </li> <li class="seamTextUnorderedListItem">Tecentriq is a type of immunotherapy called a PD-L1 checkpoint inhibitor. It is approved to treat locally advanced or metastatic triple-negative, PD-L1-positive breast cancer. </li> <li class="seamTextUnorderedListItem">Abraxane is a chemotherapy drug used to treat advanced breast cancer. </li> <li class="seamTextUnorderedListItem">This study also is enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03961698' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.infi.com/home/our-development-program/ipi-549/' target='_blank'>Drug Company Information Page: IPI-549</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tecentriq.com/sclc.html?c=pdl-16d97f8fb9c&gclid=Cj0KCQiAtrnuBRDXARIsABiN-7Ap43URSS2rpiy3bh9KrbUqV-3pLCuvw7edYCY1v2MKoHoTdD369TUaArAsEALw_wcB&gclsrc=aw.ds' target='_blank'>Genentech Information Page: Tecentriq®</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.abraxane.com' target='_blank'>Drug Company Information Page: Abraxane®</a> </li></ul>
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86

NEAREST SITE: 158 miles
Local Institution
Fresno,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03471663

D-0502 Alone or in Combination With Palbociclib for Advanced ER+, HER2- Breast Cancer

A Phase I, Open-Label Study of D-0502 Single Agent and D-0502 in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer Scientific Title

Purpose
To study the safety, effects (good and bad) and best dose of an experimental anti-estrogen therapy when it is given alone or in combination with palbociclib (Ibrance®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">D-0502, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">D-0502, by mouth</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">D-0502 is the experimental anti-estrogen therapy used in this study.</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is approved to treat hormone sensitive, HER2 negative breast cancer in combination with an anti-estrogen therapy in postmenopausal women. </li> <li class="seamTextUnorderedListItem">If you are premenopausal, you will also be given a therapy that will stop your ovaries from producing estrogen.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03471663' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/13_Supplement/5776' target='_blank'>AACR Abstract: D-0502</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/ibrance' target='_blank'>Breastcancer.org: Palbociclib (Ibrance®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com/?src_code=IBRW10028851' target='_blank'>Pfizer Oncology Drug Information Page: Ibrance® (Palbociclib)</a> </li></ul>
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87

NEAREST SITE: 171 miles
Carson Tahoe Regional Medical Center
Carson City,NV

VISITS: n/a

PHASE: II

NCT ID: NCT04266249

Neoadjuvant (Before Surgery) Chemotherapy and Targeted Therapies for Stage II-III, HER2+ Breast Cancer

(CompassHER2-pCR): Preoperative THP and Postoperative HP in Patients Who Achieve a Pathologic Complete Response (EA1181) Scientific Title

Purpose
To determine if chemotherapy after surgery can be avoided for people who have no tumor remaining after receiving chemotherapy and targeted therapy before surgery.
Who is this for?
People with stage II or stage III, HER2 positive (HER2+) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Before surgery, you will receive the following, for 3 months: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy, by IV, either once a week or every 3 weeks</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every week (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, once every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by surgery (lumpectomy or mastectomy)</i> </p> <p class="seamTextPara"> After surgery, you will be assigned to 1 of 2 groups depending upon if you had any tumor remaining: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: No tumor remaining</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, once every 3 weeks, for 6 months</li> <li class="seamTextUnorderedListItem">Pertuzumab, (Perjeta®), by IV, once every 3 weeks, for 6 months</li> <li class="seamTextUnorderedListItem">Radiation therapy and/or hormone therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Tumor remaining</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab emtansine/T-DM1 (Kadcyla®), by IV, for 10 months</li> <li class="seamTextUnorderedListItem">Radiation therapy, hormone therapy and/or chemotherapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neoadjuvant chemotherapy and targeted therapy (treatment given before surgery) is used to shrink tumors.</li> <li class="seamTextUnorderedListItem">Sometimes the tumor will disappear completely and sometimes there will still be some tumor remaining at the time of surgery. </li> <li class="seamTextUnorderedListItem">Your doctor will decide which neoadjuvant chemotherapy to give you: docetaxel (Taxotere®), nab-paclitaxel (Abraxane®), or paclitaxel (Taxol®). </li> <li class="seamTextUnorderedListItem">Everyone will receive the same anti-HER2 targeted therapies of trastuzumab (Herceptin®) and pertuzumab (Perjeta®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04266249' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ecog-acrin.org/clinical-trials/ea1181-educational-materials' target='_blank'>Cancer Research Group: CompassHER2 Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healthline.com/health/breast-cancer/chemotherapy-for-her2-positive-breast-cancer#chemotherapy-side-effects' target='_blank'>Healthline: Chemotherapy and Targeted Therapy for HER2-Positive Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/diagnosis/her2' target='_blank'>Breastcancer.org: HER2 Status</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hematologyandoncology.net/archives/may-2019/how-we-treat-locally-advanced-her2-positive-breast-cancer/' target='_blank'>Clinical Advances in Hematology & Oncology: How We Treat Locally Advanced HER2-Positive Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://esmoopen.bmj.com/content/4/3/e000515' target='_blank'>Journal Article: Neoadjuvant Treatment for Intermediate/High-Risk HER2 Positive and Triple Negative Breast Cancers</a> </li></ul>
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88

NEAREST SITE: 229 miles
Research Site
Santa Maria,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT04305496

Capivasertib & Fulvestrant or Fulvestrant Alone In Advanced ER+, HER2- Breast Cancer

A Phase III Double-blind Randomised Study Assessing the Efficacy and Safety of Capivasertib + Fulvestrant Versus Placebo + Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic Hormone Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2−) Breast Cancer Following Recurrence or Progression On or After ... Scientific Title

Purpose
To compare the anti-cancer activity of giving the targeted therapy capivasertib in combination with the anti-hormone therapy fulvestrant to giving fulvestrant alone.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer. You must have already been treated with an aromatase inhibitor and you must not have received more than one chemotherapy and two hormone therapies for advanced or metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice the first month, then once a month, ongoing </li> <li class="seamTextUnorderedListItem">Capivasertib, by mouth, twice a day, 4 days a week, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice the first month, then once a month, ongoing </li> <li class="seamTextUnorderedListItem">Placebo, by mouth, twice a day, 4 days a week, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedure for premenopausal women</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A drug that will put you into menopause, by injection, monthly, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is an anti-hormone therapy that is commonly used to treat postmenopausal women with HR+ tumors that have stopped responding to other anti-hormonal therapies.</li> <li class="seamTextUnorderedListItem">Capivasertib is a targeted therapy that blocks the Akt protein. The Akt protein helps cancer cells divide and grow.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04305496' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/akt-inhibitor-azd5363' target='_blank'>NCI Drug Dictionary: Capivasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2017/fda-fulvestrant-breast-cancer' target='_blank'>NCI Cancer Currents Blog: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/asco-2019/capivasertib-combined-with-fulvestrant-improves-pfs-in-er-breast-cancer' target='_blank'>OncLive: Capivasertib Combined With Fulvestrant Improves PFS in ER+ Breast Cancer</a> </li></ul>
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89

NEAREST SITE: 273 miles
Sansum Clinic
Santa Barbara,CA

VISITS: 3 visits over 3 months

PHASE: NA

NCT ID: NCT04436120

Next Generation Sequencing for Advanced HER2- Breast Cancer After Disease Progression

TREATMENT RESISTANCE FOLLOWING ANTI-CANCER THERAPIES (TRANSLATE) Scientific Title

Purpose
To compare the genetics of your cancer before and after you receive a targeted therapy to study why your cancer stopped responding to treatment and to help you decide which therapy or clinical trial you should try next.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-), hormone positive (ER+ and/or PR+) breast cancer or HER2 negative (HER2-) breast cancer with an inherited BRCA 1 or BRCA 2 mutation. Your cancer must have progressed while receiving palbociclib (Ibrance®) or a PARP inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy (tissue sample) of your tumor</li> <li class="seamTextUnorderedListItem">Blood draw</li> <li class="seamTextUnorderedListItem">Results of the Next Generation Sequencing (gene panel tests of your tumor and blood)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Next Generation Sequencing (NGS) is gene panel testing of your blood and tumor. </li> <li class="seamTextUnorderedListItem">NGS is a type of comprehensive genomic testing. Genomic testing looks at genetic mutations within your tumor.</li> <li class="seamTextUnorderedListItem">This information may help you and your doctor decide which therapy or clinical trial is right for you. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04436120' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pfizer.com/science/find-a-trial/nct04436120' target='_blank'>Pfizer Clinical Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/testing/types/broad-molecular-profiling-tests' target='_blank'>Breastcancer.org: Broad Molecular Profiling Tests</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medscape.com/viewarticle/899785' target='_blank'>Medscape: Should Every Metastatic Breast Cancer Patient Undergo Next-Generation Sequencing?</a> </li></ul>
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90

NEAREST SITE: 318 miles
City of Hope Antelope Valley
Lancaster,CA

VISITS: Every 3 weeks, ongoing

PHASE: II

NCT ID: NCT02778685

Femara, Palbociclib, & Pembrolizumab for Metastatic ER Positive, HER2 Negative Breast Cancer

Phase II Study of the Addition of MK-3475 (Pembrolizumab) to Letrozole and Palbociclib in Patients With Metastatic Estrogen Receptor Positive Breast Cancer Who Have Stable Disease But Are Not Responding to Letrozole and Palbociclib Scientific Title

Purpose
To study the anti-cancer activity and effects (good and bad) of adding the immunotherapy drug pembrolizumab (Keytruda®) to the commonly used combination of the anti-estrogen drug letrozole (Femara®) and the CDK 4/6 inhibitor palbociclib (Ibrance®).
Who is this for?
Women with metastatic (stage IV) estrogen receptor positive (ER+) HER2 negative (HER2-) breast cancer who have not yet started treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Letrozole (Femara®) and palbociclib (Ibrance®) are an already approved therapy combination. </li> <li class="seamTextUnorderedListItem">Letrozole (Femara®) is an anti-estrogen therapy. </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a CDK 4/6 inhibitor, which is a type of targeted therapy. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking the protein PD-1.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02778685' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Palbociclib' target='_blank'>Wikipedia: Palbociclib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com' target='_blank'>Pfizer Oncology Drug Information Page: Ibrance® (Palbociclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=CjwKCAjwycfkBRAFEiwAnLX5IZ2WUInCzwQ56GHMYYq-KXijoX1dzOK1O8HBbmaxajT0CPi2CbX3sRoC3A4QA' target='_blank'>Merck Oncology Drug Information Page: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/articles/the-evolving-field-of-erpositive-metastatic-breast-cancer-care' target='_blank'>Cure Today: The Evolving Field of ER Positive-Metastatic BC</a> </li></ul>
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91

NEAREST SITE: 326 miles
Kaiser Permanente-Woodland Hills
Woodland Hills,CA

VISITS: Visits every 3 weeks

PHASE: III

NCT ID: NCT03281954

Chemotherapy before Surgery with Atezolizumab for Triple Negative Breast Cancer

A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo Scientific Title

Purpose
To compare the safety and effects (good and bad) of using an immunotherapy along with the standard of care chemotherapy to using a placebo along with the standard of care chemotherapy before and after surgery.
Who is this for?
People with stage I, stage II, or stage III triple negative (ER-, PR-, HER2-) breast cancer. You must not have had any prior anti-cancer therapy including surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of care plus Immunotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy plus atezolizumab (Tecentriq®) by IV, every 3 weeks for 3 months</li> <li class="seamTextUnorderedListItem">followed by a different chemotherapy regimen plus atezolizumab (Tecentriq®), by IV, every 2 or 3 weeks, for 2 to 3 months</li> <li class="seamTextUnorderedListItem">followed by surgery (lumpectomy or mastectomy)</li> <li class="seamTextUnorderedListItem">followed by atezolizumab (Tecentriq®), by IV, every 3 weeks for up to 1 year </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care plus Placebo</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy plus placebo by IV, every 3 weeks for 3 months</li> <li class="seamTextUnorderedListItem">followed by a different chemotherapy regimen plus placebo, by IV, every 2 or 3 weeks, for 2 to 3 months</li> <li class="seamTextUnorderedListItem">followed by surgery (lumpectomy or mastectomy)</li> <li class="seamTextUnorderedListItem">followed by placebo, by IV, every 3 weeks for up to 1 year</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy used in this study is atezolizumab (Tecentriq®). </li> <li class="seamTextUnorderedListItem">Atezolizumab is a PD-L1 inhibitor approved to treat some triple negative (ER-, PR-, HER2-) metastatic (stage IV) breast cancers and certain types of bladder and lung cancer. </li> <li class="seamTextUnorderedListItem">It works by blocking the PD-L1 (programmed death-ligand 1) protein.</li> <li class="seamTextUnorderedListItem">The standard of care chemotherapy drugs used in this study are paclitaxel (Taxol®) and carboplatin (Paraplatin®) followed by doxorubicin (Adriamycin®) and cyclophosphamide (Cytoxan®) or epirubicin (Ellence®) and cyclophosphamide.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03281954' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org/understanding-triple-negative-breast-cancer/' target='_blank'>Triple Negative Breast Cancer Foundation: Understanding TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/patients/medicines/tecentriq' target='_blank'>Genentech: Tecentriq</a> </li></ul>
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92

NEAREST SITE: 326 miles
Kaiser Permanente-Woodland Hills
Woodland Hills,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03723928

Imaging and Tumor Mark Tests to Monitor Metastatic HR Positive, HER2 Negative Breast Cancer

Randomized Non-Inferiority Trial Comparing Overall Survival of Patients Monitored With Serum Tumor Marker Directed Disease Monitoring (STMDDM) Versus Usual Care in Patients With Metastatic Hormone Receptor Positive Breast Cancer (SWOG-S1703) Scientific Title

Purpose
To study if blood tests that look for tumor markers are as good as or better than imaging with PET and/or CT scans (the current standard of care) to determine if a tumor is growing.
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who are planning to have first line treatment for metastatic disease, or have started treatment within the past month; and have at least one elevated tumor marker.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Imaging (CT and/or PET scans), at least every 3 months, ongoing</li> <li class="seamTextUnorderedListItem">Tumor Marker Test, if ordered by your doctor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tumor Marker Tests, every 1 to 2 months, ongoing</li> <li class="seamTextUnorderedListItem">Imaging (CT and/or PET scans), only if need is shown by a Tumor Marker Test</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The tumor markers that will be tested for in this study are CA 15-3, CA27.29, and CEA.</li> <li class="seamTextUnorderedListItem">The imaging tests will be those ordered by your doctor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03723928' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/testing/types/blood_marker' target='_blank'>Breastcancer.org: Blood Marker Tests</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/about-us/collaborations/top-five-list-oncology/choosing-wisely®-top-five-cancer-related-tests-procedures-and-treatments-many-patients-do-not-need/topic-4-follow-tumor-marker-tests-and-imaging-tests-people-treated-breast-cancer' target='_blank'>ASCO Cancer.net: Follow-up Tumor Marker Tests and Imaging Tests for People Treated for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet' target='_blank'>NCI: Tumor Markers</a> </li><li class='seamTextUnorderedListItem'><a href='https://ozarkscancerresearch.org/wp-content/uploads/2019/04/SWOG-S1703.pdf' target='_blank'>Cancer Research for the Ozarks: Trial Information Page</a> </li></ul>
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93

NEAREST SITE: 330 miles
Synergy Hematology Oncology
Encino,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03382340

IMX-110 for Advanced Breast Cancer

A Phase 1/2a Open-Label, Dose-Escalation/Dose-Expansion Safety, Tolerability and Pharmacokinetic Study of IMX-110 in Patients With Advanced Solid Tumors Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of IMX-110, an experimental targeted therapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">IMX-110</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">IMX-110 is made up of a tyrosine kinase inhibitor that targets the Stat3 and NF-kB proteins and the chemotherapy drug doxorubicin. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03382340' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nccn.org/patients/resources/life_with_cancer/treatment/targeted_therapy.aspx' target='_blank'>National Comprehensive Cancer Network: Targeted Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://emedicine.medscape.com/article/1947145-medication#9' target='_blank'>MedScape: Tyrosine Kinase Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/22339066' target='_blank'>Journal Article Abstract: Doxorubicin-loaded Nanoparticles: New Advances in Breast Cancer Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='http://immixbio.com/pipeline/' target='_blank'>Drug Company Information Page: IMX-110</a> </li></ul>
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94

NEAREST SITE: 336 miles
Ronald Reagan UCLA Medical Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02554812

Using Two Immunotherapy Drugs to Treat Metastatic Triple Negative Breast Cancer

A Phase 1b/2 Open-Label Study To Evaluate Safety, Clinical Activity, Pharmacokinetics And Pharmacodynamics Of Avelumab (MSB0010718C) In Combination With Other Cancer Immunotherapies In Patients With Advanced Malignancies Scientific Title

Purpose
To study the safety of avelumab and determine the best dose of it to use along with PF-05082566.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Avelumab plus PF-05082566 (schedule determined by the physician)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Using two immunotherapy drugs together may kill more cancer cells than using one alone. </li> <li class="seamTextUnorderedListItem">Avelumab and PF-05082566 are two new immunotherapy drugs now in clinical trials. </li> <li class="seamTextUnorderedListItem">Both work by blocking a protein called PD-L1. </li> <li class="seamTextUnorderedListItem">Blocking this protein allows the immune system to find and kill cancer cells. </li> <li class="seamTextUnorderedListItem">Some of these patients will receive the immunotherapy drug PF-04518600 along with avelumab.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02554812' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02554812?term=NCT02554812&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.pfizer.com/news/press-release/press-release-detail/asco_2016_pivotal_avelumab_study_shows_positive_results_in_metastatic_merkel_cell_carcinoma' target='_blank'>Pfizer: Avelumab Study</a> </li></ul>
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95

NEAREST SITE: 336 miles
University of California, Los Angeles
Los Angeles,CA

VISITS: 1 visit

PHASE: NA

NCT ID: NCT02866994

An Internet-based Support Program for Women with Metastatic Breast Cancer

Project Connect: Enhancing Connections During Metastatic Breast Cancer (PCO) Scientific Title

Purpose
To study whether women with metastatic breast cancer benefit from creating a personal website about their breast cancer experience that they can share with friends, family members and other women diagnosed with breast cancer.
Who is this for?
Women with metastatic (stage IV) breast cancer who live in the greater Los Angeles area.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will participate in a 3-hour workshop to create a personal website and chronicle your breast cancer experience.</p>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02866994' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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96

NEAREST SITE: 336 miles
UCLA Hematology & Oncology Clinic
Los Angeles,CA

VISITS: 1 visit every 2-3 weeks

PHASE: I

NCT ID: NCT03219268

MGD013 With or Without Margetuximab for People With HER2 Positive Advanced Breast Cancer

A Phase 1, First-in-Human, Open-Label, Dose Escalation Study of MGD013, A Bispecific DART® Protein Binding PD-1 and LAG-3 in Patients With Unresectable or Metastatic Neoplasms Scientific Title

Purpose
To study the safety, effects (good and bad), and best dose of the immunotherapy MGD013 when used alone or in combination with the anti-HER2 targeted therapy margetuximab.
Who is this for?
People with HER2 positive (HER2+) advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> This is a 2-part study. Depending upon which part of the trial is open when you enroll, you will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 1: All solid tumor cancers</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MGD013, by IV, every 2-3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 2: HER2 positive cancers only</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MGD013, by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Margetuximab, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MGD013 is an investigational immunotherapy (only available in clinical trials) called a checkpoint inhibitor.</li> <li class="seamTextUnorderedListItem">MGD013 binds to the checkpoint inhibitors (proteins) PD-1 and LAG3, which helps your immune system go after cancer cells. </li> <li class="seamTextUnorderedListItem">Margetuximab is an investigational anti-HER2 targeted therapy. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced or metastatic solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03219268' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/792154' target='_blank'>NCI Drug Dictionary: MGD013</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.macrogenics.com/mgd013-pd-1-x-lag-3/' target='_blank'>Macrogenics Drug Information Page: MGD013</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Margetuximab' target='_blank'>Wikipedia: Margetuximab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/immune-checkpoint-inhibitor' target='_blank'>NCI Dictionary of Cancer Terms: Immune Checkpoint Inhibitor</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nationalbreastcancer.org/breast-cancer-targeted-therapy' target='_blank'>National Breast Cancer Foundation: Targeted Therapy</a> </li></ul>
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97

NEAREST SITE: 336 miles
(IRB#17-001086) Ronald Reagan UCLA Medical Center, Drug Information Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03284723

PF-06804103 in HER2+ Advanced Breast Cancer

A PHASE 1 DOSE ESCALATION STUDY EVALUATING THE SAFETY AND TOLERABILITY OF PF-06804103 IN PATIENTS WITH HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) POSITIVE SOLID TUMORS Scientific Title

Purpose
To study the safety and effects (good and bad) of PF-06804103 (an anti-body drug conjugate).
Who is this for?
People with locally advanced (stage III) or metastatic (stage IV) HER2+ breast cancer and have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PF-06804103 by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PF-06804103 is an antibody drug conjugate (ADC). It uses a HER2-targeted agent to deliver the chemotherapy drug Auristatin-0101 directly to HER2+ cancer cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of HER2+ solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03284723' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-her2-vc0101-adc-pf-06804103' target='_blank'>NCI Dictionary: PF-06804103</a> </li></ul>
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98

NEAREST SITE: 336 miles
University of California, Los Angeles
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03401385

DS-1062a in Advanced Triple Negative Breast Cancer

Phase 1, Two-part, Multicenter, Open-label, Multiple Dose, First-in-human Study of DS-1062a in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, best dose, and effects (good and bad) of DS-1062a.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DS-1062a</li> <li class="seamTextUnorderedListItem">2 biopsies</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DS-1062a is an investigational antibody-drug conjugate (ADC). This type of drug uses an antibody that targets cancer cells to deliver a chemotherapy drug directly to these cells.</li> <li class="seamTextUnorderedListItem">The antibody in this drug targets Trop-2 proteins. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03401385' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793720' target='_blank'>NCI Drug Dictionary: DS-1062a</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2019/05/01/mbc-news-11/' target='_blank'>Metastatic Trial Talk: Getting to the Target, Antibody Drug Conjugates in Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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99

NEAREST SITE: 336 miles
Ronald Reagan UCLA Medical Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03674827

A Vaccine-Based Immunotherapy For Stage IV Triple Negative Breast Cancer

A Phase 1 Study To Evaluate The Safety, Pharmacokinetics, And Pharmacodynamics Of Escalating Doses And Treatment Intensification Of A Vaccine-based Immunotherapy Regimen-2 (Vbir-2) (Pf-06936308) For Advanced Non-small Cell Lung Cancer And Metastatic Triple-negative Breast Cancer Scientific Title

Purpose
To investigate the safety and effects (good and bad) of increasing doses of a vaccine-based immunotherapy called TPF-06936308.
Who is this for?
People with metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PF-06936308, 4 times every 4 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The vaccine (TPF-06936308) is designed to make immune cells find and then stop the growth of cancer cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with advanced non-small cell lung cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03674827' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/795350' target='_blank'>Cancer.gov: Adenoviral cancer vaccine PF-06936308</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/navigating-cancer-care/how-cancer-treated/immunotherapy-and-vaccines/what-are-cancer-vaccines' target='_blank'>Cancer.net: What are Cancer Vaccines?</a> </li></ul>
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100

NEAREST SITE: 336 miles
University of California, Los Angeles
Los Angeles,CA

VISITS: Weekly visits for 6 weeks, then 1 visit every 3 weeks for 2 years

PHASE: I

NCT ID: NCT03719326

Immunotherapy Plus Chemotherapy for Advanced Triple Negative Breast Cancer

A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Breast and Gynecologic Malignancies Scientific Title

Purpose
To evaluate the best dose, safety and effects (good and bad) of AB928 when it is used along with pegylated liposomal doxorubicin (PLD).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer that has progressed on or not responded to available therapies.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AB928, by injection, once a week for 6 weeks, then once every 3 weeks for 2 years </li> <li class="seamTextUnorderedListItem">Pegylated liposomal doxorubicin (DOXIL®), by IV, once every 3 weeks for 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AB928 is a targeted therapy that researchers think can boost the immune system.</li> <li class="seamTextUnorderedListItem">Pegylated liposomal doxorubicin (Doxil®) is a chemotherapy drug used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03719326' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncolink.org/cancer-treatment/oncolink-rx/doxorubicin-liposomal-doxil-r' target='_blank'>OncoLink: Doxorubicin Liposomal (Doxil®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.arcusbio.com/pipeline/ab928/' target='_blank'>Arcus: AB928</a> </li></ul>
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101

NEAREST SITE: 336 miles
UCLA Hematology & Oncology Clinic
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03849469

XmAb®22841 and Pembrolizumab in Advanced Triple Negative Breast Cancer

A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®22841 Monotherapy and in Combination With Pembrolizumab in Subjects With Selected Advanced Solid Tumors (DUET-4) Scientific Title

Purpose
To determine the best dose, safety and effects of XmAb22841 when it is used alone or in combination with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">XmAb®22841</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">XmAb®22841</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">XmAb22841 is a new type of immunotherapy that targets CTLA-4 and LAG-3. </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor. It is approved to certain types of cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03849469' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.xencor.com/pipeline/' target='_blank'>Drug company information page: XmAb®22841</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/latest-news/fda-approves-keytruda-pembrolizumab-for-any-tumor-with-specific-genetic-change.html' target='_blank'>Cancer.org: FDA Approves Keytruda (Pembrolizumab) for Any Tumor with Specific Genetic Change</a> </li></ul>
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102

NEAREST SITE: 338 miles
Cancer Center of Southern California
Santa Monica,CA

VISITS: 1 visit every week, ongoing

PHASE: I

NCT ID: NCT03099174

Xentuzumab, Abemaciclib & an Anti-Estrogen Drug for Advanced Breast Cancer

An Open Label, Phase Ib Dose-escalation Study Evaluating the Safety and Tolerability of BI 836845 and Abemaciclib in Patients With Locally Advanced or Metastatic Solid Tumors and in Combination With Endocrine Therapy in Patients With Locally Advanced or Metastatic Hormone Receptor-positive Breast Cancer, Followed by Expansion Cohorts Scientific Title

Purpose
To study the best dose, safety, and anti-cancer activity of combining the CDK 4/6 inhibitor abemaciclib (Verzenio®) with xentuzumab and an anti-estrogen therapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV), hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who have received no more than two therapies for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Xentuzumab (BI 836845), by IV, weekly, ongoing</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Hormone therapy (letrozole/Femara®, anastrozole/Arimidex®, or fulvestrant/Faslodex®), by mouth or injection, daily or monthly, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">If you are premenopausal, you will also be given a therapy to stop your ovaries from producing estrogen</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Xentuzumab is an investigational targeted therapy that blocks insulin-like growth factor (IGF).</li> <li class="seamTextUnorderedListItem">Studies suggest it may improve how cancer cells respond to chemotherapy.</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®) is a CDK 4/6 inhibitor that is commonly used to treat metastatic, hormone positive (ER+ and/or PR+) breast cancer.</li> <li class="seamTextUnorderedListItem">The anti-estrogen drug you are given will be letrozole (Femara®), anastrozole (Arimidex®) or fulvestrant (Faslodex®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03099174' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/xentuzumab' target='_blank'>NCI Drug Dictionary: Xentuzumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verzenio.com' target='_blank'>Eli Lilly and Company Drug Information Page: Verzenio® (Abemaciclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/view/xentuzumab-combination-shows-promise-in-advanced-breast-cancer' target='_blank'>Cure Today: Xentuzumab Combination Shows Promise in Advanced Breast Cancer</a> </li></ul>
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103

NEAREST SITE: 338 miles
Research Site
Santa Monica,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04293094

AMG 650 for People With Advanced Triple Negative Breast Cancer

A Phase 1, Multicenter, Open-label, Dose-Exploration and Dose-Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 650 in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, effects (good and bad), and best dose of the experimental drug AMG 650.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have had at least one chemotherapy for advanced or metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <p class="seamTextPara"> AMG 650, by mouth, ongoing</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04293094' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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104

NEAREST SITE: 339 miles
UCLA School of Medicine
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT01351103

LGK974 and PDR001 for Advanced Triple Negative Breast Cancer

A Phase I, Open-label, Dose Escalation Study of Oral LGK974 in Patients With Malignancies Dependent on Wnt Ligands Scientific Title

Purpose
To study the best dose and effects (good and bad) of using the experimental targeted therapy LGK974 (WNT974) in combination with the experimental immunotherapy PDR001 (spartalizumab).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer with no other treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LGK974 (WNT974), by mouth</li> <li class="seamTextUnorderedListItem">PDR001 (spartalizumab), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Wnt pathway is a network of proteins that may play a role in how cancer develops. </li> <li class="seamTextUnorderedListItem">LGK974 (WNT974) is a targeted therapy designed to inhibit the Wnt pathway.</li> <li class="seamTextUnorderedListItem">PDR001 (spartalizumab) is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced or metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01351103' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/cancer-frontline/phase-i-clinical-trial-shows-wnt974-in-combination-with-spartalizumab-well-tolerated-for-advanced-solid-tumor-patients.h00-159381156.html' target='_blank'>MD Anderson Cancer Center: Phase I clinical trial shows WNT974 in combination with spartalizumab well tolerated for advanced solid tumor patients</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/porcupine-inhibitor-wnt974' target='_blank'>NCI Drug Dictionary: LGK974 (WNT974)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/spartalizumab' target='_blank'>NCI Drug Dictionary: PDR001 (Spartalizumab)</a> </li></ul>
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105

NEAREST SITE: 339 miles
UCLA Santa Monica Hematology / Oncology SC
Santa Monica,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT02890069

Immunotherapy Plus a Targeted Drug for Advanced Triple Negative Breast Cancer

Phase Ib, Open-label, Multi-center Study to Characterize the Safety, Tolerability and Pharmacodynamics (PD) of PDR001 in Combination With LCL161, Everolimus (RAD001) or Panobinostat (LBH589) Scientific Title

Purpose
To look at whether a new checkpoint inhibitor, a type of immunotherapy drug, is safe and effective when given along with a targeted drug.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer. (ER-, PR, HER2-) Your cancer must have progressed on or not responded to available therapies.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PDR001 and LCL161</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PDR001 and everolimus (Afinitor®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PDR001 and Panobinostat (LBH589)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy drug used in this study is called PDR001. </li> <li class="seamTextUnorderedListItem">You will receive one of three targeted drugs: LCL161, everolimus (Afinitor®), or panobinostat (LBH589).</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02890069' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2016-01890' target='_blank'>Cancer.gov Trial Information</a> </li></ul>
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106

NEAREST SITE: 339 miles
UCLA - Medical Center
Santa Monica,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03523572

Trastuzumab Deruxtican (DS-8201a) Plus Immunotherapy for Advanced HER2 Positive or HER2 Low Expression Breast Cancer

A Phase 1b, Multicenter, Two-Part, Open-Label Study of DS-8201a, an Anti-Human Epidermal Growth Factor Receptor-2 (HER2)-Antibody Drug Conjugate (ADC), in Combination With Nivolumab, an Anti-PD-1 Antibody, for Subjects With HER2-expressing Advanced Breast and Urothelial Cancer Scientific Title

Purpose
To test the safety and effects (good and bad) of the HER2 targeted therapy trastuzumab deruxtican (DS-8201a) when it is given in combination with an immunotherapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+) or HER2 low expression breast cancer whose cancer did not respond to standard therapies    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab deruxtican (DS-8201a), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DS-8201a (Trastuzumab deruxtecan) is a new type of HER2-targeted therapy. </li> <li class="seamTextUnorderedListItem">It is an antibody-drug conjugate (ADC), which means it uses an antibody to deliver a chemotherapy drug directly to the cancer cells. </li> <li class="seamTextUnorderedListItem">HER2 low expression is defined as IHC 1+ or IHC 2+/ISH-</li> <li class="seamTextUnorderedListItem">The immunotherapy being used in this study is the PD-1 inhibitor nivolumab (Opdivo®). By blocking PD-1, it allows your immune system to see and go after cancer cells. </li> <li class="seamTextUnorderedListItem">Opdivo is approved to treat certain types of cancers. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03523572' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-grants-ds8201-breakthrough-designation-for-her2-breast-cancer' target='_blank'>OncLive: FDA Grants DS-8201 Breakthrough Designation for HER2+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://adcreview.com/news/updated-analysis-ongoing-phase-trial-ds-8201-confirms-significant-benefit-her2-breast-cancer-patients-pretreated-ado-trastuzumab-emtansine/' target='_blank'>ADC Review: Trial Update of DS-8201</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/issues/april-10-2018/potent-anti-her2-agents-on-the-horizon/' target='_blank'>ASCO: Potent Anti-HER2 Agents</a> </li><li class='seamTextUnorderedListItem'><a href='https://adcreview.com/adc-university/adcs-101/antibody-drug-conjugates-adcs/' target='_blank'>ADC Review: What Are Antibody-Drug Conjugates?</a> </li></ul>
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107

NEAREST SITE: 339 miles
The Angeles Clinic and Research Center
Los Angeles,CA

VISITS: 1 visit every 2 or 4 weeks

PHASE: I

NCT ID: NCT03538028

Immunotherapy INCAGN02385 in Advanced Triple Negative Breast Cancer

A Phase 1 Open-Label, Dose-Escalation, Safety and Tolerability Study of INCAGN02385 in Participants With Select Advanced Malignancies Scientific Title

Purpose
To test the safety and effects (good and bad) of a new type of immunotherapy called INCAGN02385.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) that has not responded to other treatment options.    Full eligibility criteria
Contact research site
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NCAGN02385, by IV, once every 2 or 4 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy, INCAGN02385, gets the immune system to see and go after cancer cells by activating a molecule found on T cells called LAG-3. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03538028' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/13_Supplement/3819' target='_blank'>Cancer Research Abstract: INCAGN02385</a> </li></ul>
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108

NEAREST SITE: 339 miles
The Angeles Clinic and Research Institute
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03665285

NC318 for Advanced Triple-Negative Breast Cancer

A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To study the best dose, safety, and effects (good and bad) of an experimental cancer drug called NC318.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple-negative (ER-, PR-, HER2-) breast cancer that has low levels of the protein PD-L1 and have no standard treatment options.    Full eligibility criteria
Contact research site
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Contact Research Sites

  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NC318, by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i> </p> <p class="seamTextPara"> <u>Additional procedures</u> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 or 2 biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NC318 is designed to block a protein, called S15, that keeps the immune system from killing cancer cells. </li> <li class="seamTextUnorderedListItem">Blocking this protein could help the immune system see and go after cancer cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03665285' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/796496' target='_blank'>NCI Drug Dictionary: NC318</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.nextcure.com/pipeline/' target='_blank'>Drug Company Information Page: NC318</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/monoclonal-antibody/art-20047808' target='_blank'>Mayo Clinic: Monoclonal Antibody Drugs for Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://blog.dana-farber.org/insight/2018/03/monoclonal-antibody-therapy-cancer/' target='_blank'>Dana-Farber Cancer Institute: What is Monoclonal Antibody Therapy for Cancer?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/keytruda-faq/what-are-pd1-and-pdl1/' target='_blank'>Merk Oncology: What are PD-1 and PD-L1?</a> </li></ul>
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109

NEAREST SITE: 339 miles
University of California, Los Angeles JCCC Clinical Research Unit
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03674567

Immunotherapy for Advanced Triple Negative Breast Cancer

Phase 1/2 Dose-Escalation and Expansion Study of FLX475 Alone and in Combination With Pembrolizumab in Advanced Cancer Scientific Title

Purpose
To look at the best dose, safety and effects (good and bad) of using FLX475 alone or with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FLX475, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FLX475, by mouth</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FLX475 is an investigational targeted therapy that helps the immune system go after cancer cells. </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor. It is approved to treat certain types of cancers. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03674567' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.flxbio.com/next-generation-immune-modulators/flx475/' target='_blank'>Sponsor site: FLX475</a> </li></ul>
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110

NEAREST SITE: 339 miles
The Angeles Clinic and Research Institute
Los Angeles,CA

VISITS: May require hospitalization

PHASE: I

NCT ID: NCT04025216

CAR-T Immunotherapy for Metastatic Triple Negative & ER-Low Breast Cancer That is TnMUC1-Positive

A Phase 1 Open-Label, Multi-Center First in Human Study of TnMUC1-Targeted Genetically-Modified Chimeric Antigen Receptor T Cells in Patients With Advanced TnMUC1-Positive Solid Tumors and Multiple Myeloma Scientific Title

Purpose
To study the safety, best dose, side effects (good and bad), and anti-cancer activity of a new CAR-T cell immunotherapy that targets cancer cells that test positive for MUC1.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer that tests positive for the antigen TnMUC1. You must have already tried at least one other treatment regimen that included a PD-L1 or PD-1 inhibitor if your tumor is PD-L1 positive.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®) and fludarabine (Fludara®), by IV, once, before the CART-T immunotherapy is given</li> <li class="seamTextUnorderedListItem">CART-TnMUC1, by IV, once</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule. May require hospital stay.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">CAR-T is a personalized immunotherapy made from your white blood cells.</li> <li class="seamTextUnorderedListItem">The cells are removed from your blood, modified with chimeric antigen receptors (CARs) that allow them to attack proteins on cancer cells, and then put back in your body. </li> <li class="seamTextUnorderedListItem">The CAR-T therapy being used in this study trains the immune system to attack MUC1-positive cancer cells. </li> <li class="seamTextUnorderedListItem">Before you have the CAR-T cell therapy, you will be given the chemotherapy drugs fludarabine and cyclophosphamide. These drugs are given to prepare your immune system to receive the CAR-T cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancers that test TnMUC1-positive.</li> <li class="seamTextUnorderedListItem">Targets or mutations: TnMUC1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04025216' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/car-t-cell-therapy' target='_blank'>NCI Dictionary of Cancer Terms: CAR T-cell Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.dana-farber.org/cellular-therapies-program/car-t-cell-therapy/faq-about-car-t-cell-therapy/' target='_blank'>Dana-Farber Cancer Institute: CAR T-Cell Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tmunity.com/pipeline' target='_blank'>Drug Company Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/MUC1' target='_blank'>Wikipedia: MUC1</a> </li></ul>
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111

NEAREST SITE: 339 miles
Angeles Clinic and Research Institute, The
Santa Monica,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04042480

SGN-CD228A For Advanced HER2 Negative Breast Cancer

A Phase 1 Study of SGN-CD228A in Select Advanced Solid Tumors Scientific Title

Purpose
To study the safety and effects (good and bad) of an antibody-drug conjugate called SGN-CD228A.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative breast cancer who have already been treated with a taxane. If your tumor is ER+, you must already have been treated with a CDK4/6 inhibitor and an anti-estrogen therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SGN-CD228A, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An antibody-drug conjugate (ADC) is a type of cancer therapy that combines an antibody that targets cancer cells with a drug that can kill cancer cells. </li> <li class="seamTextUnorderedListItem">SGN-CD228A targets CD228, a protein found on several types of cancer cells. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04042480' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.marketwatch.com/press-release/seattle-genetics-highlights-antibody-drug-conjugate-innovation-and-immuno-oncology-program-at-the-american-association-for-cancer-research-aacr-annual-meeting-2019-03-27' target='_blank'>Press Release: SGN-CD228A</a> </li></ul>
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112

NEAREST SITE: 339 miles
UCLA
Santa Monica,CA

VISITS: 1 visit every 3 weeks

PHASE: I

NCT ID: NCT04064359

OBT076 in Advanced HER2 Negative Breast Cancer That Tests Positive for CD205

A Phase I, Open-label, Dose Finding Study to Assess the Safety, Tolerability, PK, and Preliminary Efficacy of OBT076, a CD205-directed ADC, in Recurrent and/or Metastatic CD205+ Solid Tumors and CD205+ HER2-negative Metastatic Breast Cancer Scientific Title

Purpose
To study the safety, best dose, and side effects (good and bad) of the investigational targeted therapy OBT076.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer whose tumor tests positive for the CD205 protein and who have no standard treatment options available.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">OBT076, by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">OBT076 is a type of therapy called an antibody-drug conjugate (ADC). These therapies combine an antibody that can find the cancer cells with a drug that can kill them. </li> <li class="seamTextUnorderedListItem">The antibody in OBT076 targets the CD205 protein and delivers a drug to make the immune system see cancer cells.</li> <li class="seamTextUnorderedListItem">Targets or mutations: CD205</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04064359' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Antibody-drug_conjugate' target='_blank'>Wikipedia: Antibody-drug Conjugates</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/ChemotherapyandTargetedTherapy.html' target='_blank'>Susan G. Komen: Emerging Areas</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/antibody-drug-conjugate' target='_blank'>NCI Dictionary of Cancer Terms: Antibody-drug Conjugate</a> </li><li class='seamTextUnorderedListItem'><a href='https://blog.aacr.org/from-the-journals-editors-picks-for-september/' target='_blank'>AACR Blog: Editors’ Picks for September</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.menarini.com/Home/Innovation-Research/MEN1309' target='_blank'>Drug Company Information Page: MEN1309 (OBT076)</a> </li></ul>
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113

NEAREST SITE: 339 miles
UCLA Hematology/Oncology Parkside
Santa Monica,CA

VISITS: 1 visit every 2 weeks, ongoing

PHASE: II

NCT ID: NCT04224272

Targeted Therapy ZW25, Palbociclib, & Fulvestrant for People with Advanced HER2+, HR+ Breast Cancer

Phase 2a Study of ZW25 in Combination With Palbociclib Plus Fulvestrant Scientific Title

Purpose
To assess the safety and effects (good and bad) of the experimental HER2-targeted therapy ZW25 when it is given with palbociclib (Ibrance®) and fulvestrant (Faslodex®).
Who is this for?
People who have advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+), hormone positive (ER+ and/or PR+) breast cancer; have previously been treated with trastuzumab (Herceptin®), pertuzumab (Perjeta®), or T-DM1 (Kadcyla®); and not have been treated with a CDK4/6 inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZW25, by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily,</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice a month for the first month, then once a month, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZW25 is a new type of HER2-targeted therapy. </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a type of targeted therapy called a CDK4/6 inhibitor. </li> <li class="seamTextUnorderedListItem">It is approved for use along with a hormone therapy to treat metastatic hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer.</li> <li class="seamTextUnorderedListItem">Faslodex is a hormone therapy approved to treat postmenopausal people with advanced breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04224272' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-her2-bi-specific-monoclonal-antibody-zw25' target='_blank'>NCI Drug Dictionary: ZW25</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/News/59508' target='_blank'>ASCO: Investigational Anti-HER2 Therapy in HER2-Expressing Solid Tumors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/herceptin' target='_blank'>Breastcancer.org: Targeted Therapies</a> </li><li class='seamTextUnorderedListItem'><a href='https://dailynews.ascopubs.org/do/10.1200/ADN.19.190160/full/' target='_blank'>ASCO: The Role of CDK4 Inhibitors in Triple-Positive Breast Cancers</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2017/fda-fulvestrant-breast-cancer' target='_blank'>NCI Cancer Currents Blog: FDA Expands Approval of Fulvestrant for Advanced Breast Cancer</a> </li></ul>
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114

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02926911

A Study Comparing Active Surveillance to Treatment for Low-Risk DCIS

Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial For Low Risk DCIS: A Phase III Prospective Randomized Trial Scientific Title

Purpose
To compare active surveillance--a mammogram every six months and optional anti-estrogen therapy--to the standard of care for treating DCIS.
Who is this for?
Women with hormone receptor positive (ER+ and/or PR+) DCIS who have not yet started treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and undergo the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery with or without radiation</li> <li class="seamTextUnorderedListItem">followed by mammogram, every 12 months for 5 years</li> <li class="seamTextUnorderedListItem">Optional endocrine therapy for 5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Active Monitoring</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mammogram, every 6 months for 5 years</li> <li class="seamTextUnorderedListItem">Optional endocrine therapy for 5 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Not all DCIS will become invasive breast cancer. This means that some women being treated for DCIS are getting more treatment than is necessary. </li> <li class="seamTextUnorderedListItem">The standard of care is surgery, which may be followed by radiation and/or anti-estrogen treatment.</li> <li class="seamTextUnorderedListItem">For more information, email: thomas.lynch2@duke.edu</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02926911' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://dcisoptions.org/' target='_blank'>COMET study website</a> </li><li class='seamTextUnorderedListItem'><a href='https://am.asco.org/when-less-more-breast-cancer-treatment' target='_blank'>ASCO: When 'Less is More' in Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pcori.org/research-results/2016/comparing-treatment-options-women-low-risk-ductal-carcinoma-situ-dcis-comet' target='_blank'>PCORI: Study information</a> </li></ul>
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115

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA

VISITS: Coincides with type of therapy

PHASE: NA

NCT ID: NCT03098576

Molecular Tumor Profiling to Select Targeted Therapies for People With Advanced Breast Cancer

A Basket Study: Personalized Cancer Care at Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute Scientific Title

Purpose
To study the effects (good and bad) of choosing a targeted therapy for treatment based on the results of molecular profiling of your tumor.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer. You must also have had at least one treatment your tumor did not respond to or progressed on.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups based on the results of your molecular profiling: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Matched targeted drug treatment</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will receive a drug that is targeted to a specific genetic abnormality (mutation) if one is found in your tumor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will receive the standard of care therapy if no genetic abnormality (mutation) is found in your tumor</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Molecular profiling is a process that identifies mutations and biomarkers in your tumor's DNA that have FDA-approved matched therapies or are eligible for clinical trials.</li> <li class="seamTextUnorderedListItem">In this study, a sample of your tumor will be analyzed (called molecular profiling) at Cedars-Sinai Medical Center in California.</li> <li class="seamTextUnorderedListItem">Targets or mutations: varies based on your test results</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03098576' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/KomenPerspectives/Tumor-profiling-–-personalizing-treatment-for-breast-cancer.html' target='_blank'>Susan G. Komen: Tumor Profiling--Personalized Treatment For Breast Cancer</a> </li></ul>
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116

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA

VISITS: 3 visits every month, ongoing

PHASE: I

NCT ID: NCT03129139

Minnelide™ Capsules and Chemotherapy for Metastatic Breast Cancer

A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Protein-Bound Paclitaxel in Patients With Advanced Solid Tumors Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using Minnelide™ along with the chemotherapy drug protein-bound paclitaxel (Abraxane®).
Who is this for?
People with metastatic (stage IV) breast cancer and have no standard cancer treatment options available.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Minnelide™, by mouth, daily (3 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Abraxane® (protein-bound paclitaxel), by IV, once a week (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Minnelide™ is an experimental heat shock protein (HSP) inhibitor. </li> <li class="seamTextUnorderedListItem">Abraxane is used to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">This study is also enrolling people with other types of cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03129139' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/protein-bound-paclitaxel' target='_blank'>NCI Dictionary of Cancer Terms: Protein-bound Paclitaxel</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/triptolide-analogue' target='_blank'>NCI Drug Dictionary: Triptolide Analogue (Minnelide™)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515388/' target='_blank'>Journal Article: Minnelide™ for Pancreatic and Liver Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.abraxane.com/mbc/' target='_blank'>Drug Company Information Page: Abraxane</a> </li></ul>
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117

NEAREST SITE: 341 miles
Cedars Sinai Medical Center / Samuel Oschin Comprehensive Cancer Institute
Los Angeles,CA

VISITS: Visits every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03310957

SGN-LIV1A and Keytruda for Advanced Triple Negative Breast Cancer

Single Arm, Open Label Phase 1b/2 Study of SGN-LIV1A in Combination With Pembrolizumab for First-Line Treatment of Patients With Unresectable Locally-Advanced or Metastatic Triple-Negative Breast Cancer Scientific Title

Purpose
To look at the safety and effects (good and bad) of using SGN-LIV1A along with pembrolizumab (Keytruda®) to treat triple negative advanced or metastatic breast cancer.
Who is this for?
People with advanced (some stage III) and metastatic (stage IV) breast cancer that is triple negative. You may not have received prior treatment for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SGN-LIV1A, by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SGN-LIV1A is an investigational drug that targets a protein called LIV-1 that is found on some tumor cells. </li> <li class="seamTextUnorderedListItem">Keytruda® is a type of immunotherapy drug called a PD-1 inhibitor. It blocks the PD-1 (programmed cell death-1) protein, making it possible for the body's immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">Keytruda® is approved to treat certain types of cancer, including breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03310957' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/News/20659' target='_blank'>ASCO Post: Keytruda for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://investor.seattlegenetics.com/phoenix.zhtml?c=124860&p=irol-newsArticle&ID=2305936' target='_blank'>Seattle Genetics: SGN-LIV1A</a> </li></ul>
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118

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA

VISITS: 2 visits, over 3 weeks

PHASE: I-II

NCT ID: NCT03366844

Pembrolizumab and Radiation before Surgery for Stage II-III Triple Negative and Select HR+, HER2- Breast Cancer

Pilot Study of the Preoperative Combination of Pembrolizumab and Radiation Therapy in Patients With Operable Breast Cancer Scientific Title

Purpose
To look at the effects (good and bad) of giving pembrolizumab (Keytruda®) and radiation therapy before surgery.
Who is this for?
Women with stage II or stage III, estrogen receptor positive (ER+), HER2 negative (HER2-) or triple negative (ER-, PR-, HER2-) breast cancer planning to receive breast-conserving surgery (lumpectomy).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, twice over 3 weeks </li> <li class="seamTextUnorderedListItem">Radiation therapy, once, along with second dose of Pembrolizumab</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving treatment before surgery is called neoadjuvant therapy. It gives researchers the ability to study the effect the treatment has on the cancer cells. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. By blocking PD-1, it helps the immune system see and kill cancer cells. Keytruda is approved to treat certain types of cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Radiation is commonly used to treat women with breast cancer who have had a lumpectomy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03366844' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biospace.com/article/merck-s-keytruda-hits-another-endpoint-this-time-in-triple-negative-breast-cancer/' target='_blank'>Biospace: Keytruda in TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/blog/2019-02/immunotherapy-breast-cancer-treatment-it-option' target='_blank'>Cancer.net: Immunotherapy for Breast Cancer Treatment: Is It an Option?</a> </li></ul>
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119

NEAREST SITE: 341 miles
Cedar-Sinai
Beverly Hills,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03530696

T-DM1 and Palbociclib for Advanced HER2 Positive Breast Cancer

A Randomized Phase II Study to Evaluate Efficacy of T-DM1 With or Without Palbociclib in the Treatment of Patients With Metastatic HER2 Positive Breast Cancer Scientific Title

Purpose
To compare the side effects and effectiveness of the combination of T-DM1 (Kadcyla®) and palbociclib (Ibrance®) to T-DM1 (Kadcyla®) alone.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2-positive breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, 2 weeks on, 1 week off </li> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®), by IV, once every 3 weeks </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Kadcyla® is a HER2-targeted therapy that combines the chemotherapy drug DM1 with the HER2 targeted therapy trastuzumab (Herceptin). </li> <li class="seamTextUnorderedListItem">It is approved for patients with previously treated HER2-positive metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Ibrance® is a CDK4/6 inhibitor approved to treat metastatic breast cancer when given along with hormone therapy--either letrozole (Femara®) or fulvestrant (Faslodex®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03530696' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://cslide.ctimeetingtech.com/library/esmo/browse/search/258K#2F3503b' target='_blank'>ESMO: Palbociclib in combination with TDM1 for metastatic HER2+ breast cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/RecommendedTreatmentsforMetastaticBreastCancer.html' target='_blank'>Susan G. Komen: Trastuzumab emtansine (T-DM1, Kadcyla)</a> </li></ul>
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120

NEAREST SITE: 341 miles
Cedars Sinai Medical Center
Los Angeles,CA

VISITS: Number of visits unavailable, over 2 months

PHASE: II

NCT ID: NCT03546686

Immunotherapy & Cryoablation Before Surgery in Taxane Treated Triple Negative Tumors

A Randomized Phase 2 Study of Peri-Operative Ipilimumab, Nivolumab and Cryoablation Versus Standard Peri-Operative Care in Women With Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer. Scientific Title

Purpose
To study the safety and effects (good and bad) of using cryoablation, ipilimumab (Yervoy®) and nivolumab (Opdivo ®) after neoadjuvant chemotherapy and before surgery.
Who is this for?
Women with stage I, stage II, or stage IIIa triple negative (ER-, PR-, HER2-) breast cancer who had taxane-based chemotherapy before surgery and still have some tumor remaining.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®), by IV, 1-5 days prior to core biopsy and cryoablation</li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, 1-5 days prior to core biopsy and cryoablation, and then every 2 weeks after surgery, for 6 weeks</li> <li class="seamTextUnorderedListItem">Core biopsy/Cryoablation, 7-10 days prior to surgery</li> <li class="seamTextUnorderedListItem">Breast surgery (standard-of-care) </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation uses extreme cold to kill cancer cells. It is not an established breast cancer treatment. </li> <li class="seamTextUnorderedListItem">Yervoy is an immunotherapy. It gets the immune system to see cancer cells by blocking the CTLA-4 protein. It is approved to treat metastatic melanoma. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Opdivo is an immunotherapy that gets the immune system to go after cancer cells by blocking a protein called PD-1. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03546686' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/ipilimumab-yervoy' target='_blank'>Cancer Research UK: Ipilimumab (Yervoy)</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/Nivolumab.aspx' target='_blank'>Chemocare: Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/cryotherapy' target='_blank'>Breastcancer.org: Cryotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedaily.com/releases/2018/11/181128082721.htm' target='_blank'>Science Daily: Cryoablation</a> </li></ul>
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121

NEAREST SITE: 341 miles
Cedars Sinai Medical Center
Los Angeles,CA

VISITS: Weekly visits for 3 months

PHASE: II

NCT ID: NCT03747120

Chemotherapy, HER2 Targeted Therapy, & Immunotherapy Before Surgery in HER2+ Breast Cancer

Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab (neoHIP) Scientific Title

Purpose
To compare the safety and effects (good and bad) of three different breast cancer treatment regimens that will be given before breast cancer surgery.
Who is this for?
People with stage I, stage II, or stage III HER2 positive (HER2+) breast cancer who have not yet received any treatment for breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Taxol/Herceptin/Perjeta (THP)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 months</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks, for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Taxol/Herceptin/Perjeta-Keytruda (THP-K)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Same treatment as Group 1 plus:</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Taxol/Herceptin-Keytruda (TH-K)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 months</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, for 3 months</li></ul>
  • <p class="seamTextPara"> <i class="seamTextEmphasis">The drugs used in different combinations for treatment:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ttrastuzumab (Herceptin®), a HER2-targeted therapy </li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), a HER2-targeted therapy</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), an immunotherapy</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), a chemotherapy</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03747120' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/Trastuzumab.html' target='_blank'>Susan G. Komen: Targeted Therapies for HER2-Positive Early Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/issues/december-10-2018/management-of-her2-positive-breast-cancer/' target='_blank'>ASCO Post: Management of HER2-Positive Breast Cancer: Business as Usual?</a> </li></ul>
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122

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA

VISITS: Please contact research site

PHASE: I

NCT ID: NCT03775525

GZ17-6.02 for Metastatic Breast Cancer (GEN602)

A Phase I, Multicenter, Open-label, Dose-Escalation, Safety, Pharmacodynamic and Pharmacokinetic Study of GZ17-6.02 Given Orally on a Daily x 28 Day Schedule in Patients With Advanced Solid Tumors or Lymphoma Scientific Title

Purpose
To study the safety and effects (good and bad) of a new type of cancer drug called GZ17-6.02.
Who is this for?
People with metastatic (stage IV) breast cancer who have no other available standard treatment options.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GZ17-6.02, by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers have found that GZ17-6.02 blocks the super-enhancers that send signals for cells to grow. </li> <li class="seamTextUnorderedListItem">This study is also enrolling women with advanced endometrial cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03775525' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://mct.aacrjournals.org/content/17/1_Supplement/LB-A26' target='_blank'>AACR Abstract: GZ17-6.02</a> </li></ul>
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123

NEAREST SITE: 342 miles
California Research Institute
Los Angeles,CA

VISITS: Weekly visits for 4 months

PHASE: I

NCT ID: NCT02626507

Gedatolisib, Ibrance and Faslodex Before Surgery in Women With ER+ HER2- Breast Cancer

Phase I Dose-Escalation Study of Combination of Gedatolisib (a Dual Inhibitor of PI3-K and mTOR) With Palbociclib and Faslodex in the Neoadjuvant Setting in Previously Untreated Patients With ER+/HER2- Breast Cancer Scientific Title

Purpose
To test the safety and effects (good and bad) and best dose of the targeted therapy gedatolisib when used along with fulvestrant (Faslodex®) and palbociclib (Ibrance®).
Who is this for?
Women with ER-positive HER2-negative stage I, II, III or IV (metastatic) breast cancer who has not yet had any breast cancer treatments and is scheduled to have a lumpectomy or a mastectomy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following treatment before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gedatolisib, by IV, once a week for 4 months</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice a month in the first month, then monthly for the remaining 3 months</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily for 3 weeks each month</li> <li class="seamTextUnorderedListItem">Goserelin (Zoladex®), by mouth, once a month, if needed</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The purpose of this study is to test the safety and effects (good or bad) and best dose of the targeted therapy gedatolisib when used along with fulvestrant (Faslodex®) and palbociclib (Ibrance®). </li> <li class="seamTextUnorderedListItem">The combination is given before surgery. This is called neoadjuvant treatment. </li> <li class="seamTextUnorderedListItem">Giving therapy before surgery allows researchers to study the effect the therapy has on the breast tumor. </li> <li class="seamTextUnorderedListItem">Gedatolisib kills cancer cells by blocking the PI3K/mTOR pathway. </li> <li class="seamTextUnorderedListItem">Faslodex® is a hormone therapy approved to treat advanced breast cancer in postmenopausal women. </li> <li class="seamTextUnorderedListItem">Ibrance® is a type of targeted therapy called a CDK 4/6 inhibitor. It is approved to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">If you are premenopausal, you will also be given the drug goserelin (Zoladex®), which will put you in temporary menopause.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02626507' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancer-news.com/2017/11/15/advanced-breast-cancer-therapy-combo-faslodex-fulvestrant-ibrance-palbociclib-approved-eu/' target='_blank'>Breast Cancer News: European Commission Approves Faslodex-Ibrance Combo for Advanced Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/palbociclib' target='_blank'>NCI Drug dictionary: Palbociclib (Ibrance®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/fulvestrant' target='_blank'>NCI Drug dictionary: Fulvestrant (Faslodex®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/goserelinacetate' target='_blank'>NCI Drug dictionary: Goserelin (Zoladex®)</a> </li></ul>
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124

NEAREST SITE: 347 miles
City of Hope South Pasadena
South Pasadena,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT01905046

Metformin to Reduce Breast Cancer Risk in Women with Increased Risk of Developing Breast Cancer

Testing for Atypia in Random Periareolar Fine Needle Aspiration (RPFNA) Cytology After 12 Months Metformin (1,1-Dimethylbiguanide Hydrochloride) Chemoprevention Versus Placebo Control in Premenopausal Women Scientific Title

Purpose
To determine whether metformin is better than a placebo at reducing breast cancer risk.
Who is this for?
Women who are at increased risk of breast cancer due to family history, BRCA mutation, or breast changes including atypical hyperplasia, DCIS or LCIS.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metformin, by mouth, daily for 2 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily for 1 year (may crossover to Group 1 for 1 year)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Women who have been diagnosed with atypical hyperplasia, DCIS or LCIS are at increased risk of developing breast cancer. </li> <li class="seamTextUnorderedListItem">Researchers are trying to find drugs (chemoprevention) that can reduce this risk. </li> <li class="seamTextUnorderedListItem">Findings from previous studies suggest that metformin, a drug used to treat diabetes, can reduce breast cancer risk in high-risk women.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01905046' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/about-cancer/causes-prevention/research/metformin' target='_blank'>NCI: Metformin Help Prevent Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.net/navigating-cancer-care/prevention-and-healthy-living/chemoprevention' target='_blank'>Cancer.net: Chemoprevention</a> </li></ul>
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125

NEAREST SITE: 347 miles
South Pasadena Cancer Center
South Pasadena,CA

VISITS: 2 visits

PHASE: NA

NCT ID: NCT01992432

Studying the Effect of Chemotherapy on the Brain in Older Women

A Pilot Study of Structural and Functional Brain Magnetic Resonance Imaging Findings of Chemotherapy Toxicity in Older Women With Breast Cancer Scientific Title

Purpose
To study how advanced MRI techniques characterize the changes that occur in the brain.
Who is this for?
Women age 65 and older receiving adjuvant chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants undergo: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain fMRI (functional MRI) before and after chemotherapy</li> <li class="seamTextUnorderedListItem">Cognitive testing before and after chemotherapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy can cause short-and long-term difficulties with cognitive functioning, a problem often referred to as <q>chemo brain</q> </li> <li class="seamTextUnorderedListItem">Older adults may be at increased risk of developing cognitive problems from chemotherapy.</li> <li class="seamTextUnorderedListItem">Results of this study will lay the foundation for future, larger scale studies on the impact of chemotherapy on cognitive functioning in adults age 65 and older.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01992432' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://breakthroughs.cityofhope.org/chemo-brain-questions-cancer' target='_blank'>City of Hope: Chemo Brain</a> </li></ul>
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126

NEAREST SITE: 347 miles
Chan Soon-Shiong Institute for Medicine
El Segundo,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03552718

Personalized Vaccine After Completing Treatment for Breast Cancer

QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers. (QUILT-2.025) Scientific Title

Purpose
To test the safety, effects (good and bad) and best dose of an immunotherapy vaccine that can be personalized to each patient's tumor profile.
Who is this for?
People who have completed treatment for stage I, stage II or stage III breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">YE-NEO-001, by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">YE-NEO-001 is a personalized vaccine. It is produced based on an individual's tumor profile.</li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03552718' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/797413' target='_blank'>NCI Drug Dictionary: Personalized neoepitope yeast vaccine YE-NEO-001</a> </li></ul>
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127

NEAREST SITE: 348 miles
University of Southern California
Los Angeles,CA

VISITS: 3 or 5 days over 1 week

PHASE: II

NCT ID: NCT02755896

Partial Breast Radiation After Lumpectomy in Women 50 & Older with Stage I Breast Cancer

Prone Partial Breast Irradiation (PBI): Prospective Randomized Controlled Non-inferiority Trial to Compare Radiation Fibrosis With Five Versus Three Fractions Scientific Title

Purpose
To compare the effectiveness and side effects (including the development of fibrosis) of two different schedules and doses of PBI therapy.
Who is this for?
Postmenopausal women with stage I breast cancer who have had a lumpectomy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Higher-Dose Radiation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">5 radiations, 5 consecutive days over 1 week</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Lower-Dose Radiation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3 radiations, every other day over 1 week</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">During partial breast irradiation (PBI), the radiation beam is directed to the area of the breast where the cancer was removed. </li> <li class="seamTextUnorderedListItem">Radiation fibrosis®the hardening of breast tissue®is one side effect of radiation therapy. This fibrosis can cause ongoing discomfort.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02755896' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02755896?term=NCT02755896&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancerresearchuk.org/about-cancer/type/breast-cancer/treatment/radiotherapy/breast-cancer-radiotherapy-side-effects' target='_blank'>Breast Cancer Radiotherapy Side Effects:</a> </li></ul>
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128

NEAREST SITE: 348 miles
University of Southern California Keck School of Medicine
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT01670877

Neratinib For Metastatic HER2 Negative Breast Cancer That Tests Positive For A HER2 Mutation

A Phase II Study of Neratinib in Metastatic HER2 Non-amplified But HER2 Mutant Breast Cancer Scientific Title

Purpose
To study the anti-cancer activity and effects (good and bad) of Neratinib (Nerlynx®) in HER2 negative (HER2-) tumors that test positive for a HER2 genetic mutation.
Who is this for?
People with metastatic (stage IV) breast cancer that is HER2 negative (HER2-). Your tumor must test positive for a HER2 gene mutation.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, monthly, ongoing (only if your tumor is estrogen receptor positive)</li> </ul> <p class="seamTextPara"> You may also receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 2 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer tumors are tested to determine whether they are producing too many HER2 proteins. Those that do are called HER2 positive; those that don't are HER2 negative. </li> <li class="seamTextUnorderedListItem">Using a new type of test, researchers can determine if a HER2 negative tumor has a HER2 gene mutation. </li> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®) is a tyrosine kinase inhibitor that works by blocking the HER2 and EGFR pathways. </li> <li class="seamTextUnorderedListItem">It is approved for use in HER2 positive (HER2+) breast cancer but its use for HER2 negative breast, HER2 mutated breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Targets or mutations: HER2 (ERBB2)</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01670877' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/publications/obtn/2013/January-2013/HER2-Mutations-Identified-as-Treatment-Targets-in-Patients-With-HER2-Negative-Breast-Cancer' target='_blank'>OncLive: HER2 Mutations as Treatment Targets for HER2-Negative BC</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.1039' target='_blank'>ASCO Abstract: Impact of HER2 Mutation Status on Personalized Molecular Targeted Therapy in Advanced Breast Cancers</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopost.com/issues/february-1-2013/somatic-her2-mutations-that-drive-cancer-found-in-her2-negative-breast-cancer/' target='_blank'>ASCO: Somatic HER2 Mutations That Drive Cancer Found in HER2-negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/full/10.1200/PO.16.00031' target='_blank'>Journal Article: Homologous Recombination Deficiency in Breast Cancer: A Clinical Review</a> </li></ul>
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129

NEAREST SITE: 348 miles
USC Norris Comprehensive Cancer Center
Los Angeles,CA

VISITS: 1 visit

PHASE: NA

NCT ID: NCT01755208

Using Light-Scattering Spectroscopy to Analyze Breast Tissue

Light-Scattering Spectroscopy for the Detection of Stage II-III Breast Cancer: A Pilot Study Scientific Title

Purpose
To investigate whether light-scattering spectroscopy can differentiate between women who have stage II or III breast cancer and women who do not have breast cancer.
Who is this for?
Women with stage II or stage III breast cancer, or without breast cancer, scheduled to have a mammogram at the University of Southern California.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following procedure: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Light-scattering spectroscopy in addition to standard of care</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A doctor will perform a breast biopsy to learn more about an area of concern seen on a mammogram. </li> <li class="seamTextUnorderedListItem">Light-scattering spectroscopy (LSS) is an imaging technique that does not require removal of tissue samples and can provide quick results. </li> <li class="seamTextUnorderedListItem">LSS may be able to identify cell abnormalities more effectively than a biopsy.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01755208' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ncbi.nlm.nih.gov/pubmed/17280544' target='_blank'>PubMed: Light spectroscopy for early cancer detection</a> </li></ul>
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130

NEAREST SITE: 348 miles
USC Norris Comprehensive Cancer Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT01802346

Low-Calorie Diet To Reduce Side Effects of Chemotherapy

A Randomized, Phase II Clinical Trial of a Controlled Diet Prior to Selected Chemotherapy Treatment in Breast and Prostate Cancer to Evaluate the Impact on Toxicity and Efficacy Scientific Title

Purpose
To study whether patients with breast cancer who eat a controlled low-calorie diet will have fewer side effects and a better response to chemotherapy than patients who eat a normal diet. (This trial also is enrolling men with prostate cancer.)
Who is this for?
People with breast cancer    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eat a special low-calorie diet during before, during and after chemotherapy (All food provided)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eat a normal diet, receive dietary advice from a nutritionist</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy drugs attack cells that are rapidly dividing, which is why they are an effective cancer treatment. </li> <li class="seamTextUnorderedListItem">However, other cells in the body that also divide rapidly, like those in the bone marrow, mouth, intestines, and hair follicles, are also likely to be affected by chemotherapy®which can lead to side effects. </li> <li class="seamTextUnorderedListItem">It is possible that eating a low-calorie diet may reduce chemotherapy-related side effects as well as improve how the tumor responds to treatment.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01802346' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/chemotherapy/side_effects' target='_blank'>BreastCancer.org: Chemotherapy Side Effects</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-treating-chemotherapy' target='_blank'>Cancer.gov: Chemotherapy</a> </li></ul>
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131

NEAREST SITE: 348 miles
Research Site
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT02264678

Ceralasertib Alone or With Chemotherapy or With Olaparib in Advanced Breast Cancer

A Modular Phase I, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD6738 in Combination With Cytotoxic Chemotherapy and/or DNA Damage Repair/Novel Anti-cancer Agents in Patients With Advanced Solid Malignancies. Scientific Title

Purpose
To study the safety, effects, and best dose of Ceralasertib when it is used alone or with the chemotherapy drug carboplatin or the PARP inhibitor olaparib (Lynparza®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Open to all MBC patients</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ceralasertib, by mouth </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks for up to 4.5 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Open to all MBC patients </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ceralasertib, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Open to Triple Negative Breast Cancer MBC patients with or without a BRCA mutation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ceralasertib, by mouth</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3 biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ceralasertib is a new type of targeted therapy called an ATR inhibitor. </li> <li class="seamTextUnorderedListItem">It disrupts a cancer cell's ability to repair its own DNA, which can cause the cancer cells to die. </li> <li class="seamTextUnorderedListItem">Carboplatin is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Lynparza is a PARP inhibitor approved to treat BRCA 1 or BRCA 2 positive metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02264678' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/atr-kinase-inhibitor-azd6738' target='_blank'>NCI Drug Dictionary: Ceralasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/olaparib' target='_blank'>NCI Drug Dictionary: Olaparib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/publications/oncology-live/2018/vol-19-no-24/targeting-cancers-achilles-heel-dna-damage-response-networks-beyond-parp' target='_blank'>OncLive: DNA Damage Response Networks Beyond PARP</a> </li></ul>
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132

NEAREST SITE: 348 miles
USC / Norris Comprehensive Cancer Center
Los Angeles,CA

VISITS: 3 visits a week for 12 weeks

PHASE: NA

NCT ID: NCT02454777

High-Intensity Interval Training for Patients with Early-Stage Breast Cancer

High-Intensity Interval Training (HIT) for Breast Cancer Patients During Trastuzumab Use Scientific Title

Purpose
To determine if women receiving chemotherapy and Herceptin can take part in high-intensity interval training to improve their heart and overall health.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who are planning to receive trastuzumab (Herceptin®) and chemotherapy. You must speak English and/or Spanish and be between the ages of 30 and 60.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: High-Intensity Interval Training</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High-intensity training for 30 minutes, 3 times a week, for 12 weeks </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Moderate-Intensity Interval Training</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Moderate-intensity training for 30 minutes, 3 times a week, for 12 weeks </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: No Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Maintain current sedentary activity level (less than 60 minutes of total exercise per week), for 12 weeks </li> <li class="seamTextUnorderedListItem">Document weekly activity in an exercise log </li> <li class="seamTextUnorderedListItem">Option to participate in the moderate-intensity exercise program after 12 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Herceptin (a HER2 targeted therapy) may cause heart problems in some patients. </li> <li class="seamTextUnorderedListItem">Aerobic exercise, which can improve heart functioning, may help reduce the risk of these heart problems developing. </li> <li class="seamTextUnorderedListItem">Aerobic exercise may also reduce risk of recurrence and reduce fatigue.</li> <li class="seamTextUnorderedListItem">High-intensity interval training involves short bursts of high-intensity efforts followed by periods of recovery.</li> <li class="seamTextUnorderedListItem">High-intensity interval training may allow patients who are unable to exercise for a long period of time to remain physically active.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02454777' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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133

NEAREST SITE: 348 miles
USC/Norris Cancer Center
Los Angeles,CA

VISITS: Visits weekly, ongoing

PHASE: I

NCT ID: NCT02892123

A HER2-Targeted Drug for Advanced HER2-Positive Breast Cancer

Phase I Trial of ZW25 in Patients With Locally Advanced (Unresectable) and/or Metastatic HER2-expressing Cancers Scientific Title

Purpose
To investigate whether a new type of HER2-targeted drug is safe and effective. It will also determine the most effective dose of the drug that can be used safely.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive breast cancer. You must have already received at least one treatment for your cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZW25, by IV, weekly, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The drug being studied is called ZW25. </li> <li class="seamTextUnorderedListItem">This study is also open to patients with other types of HER2-positive cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02892123' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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134

NEAREST SITE: 348 miles
USC Norris
Los Angeles,CA

VISITS: 1 visit per month, for 5 months

PHASE: I-II

NCT ID: NCT03058289

INT230-6 Injections & Immunotherapy in Advanced Breast Cancer

A Phase 1/2 Safety Study of Intratumorally Administered INT230-6 in Adult Subjects With Advanced Refractory Cancers Scientific Title

Purpose
To study the effects (good and bad) of giving INT230-6 alone and with an anti-PD-1 immunotherapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer. You must have no standard of care treatments available.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">INT230-6, by injection, into your tumor, monthly, for 5 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">If you are in the combination treatment cohort, you will also receive an anti-PD1 drug (schedule determined by the physician)</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">INT230-6 is a combination chemotherapy treatment that is injected directly into the tumor. </li> <li class="seamTextUnorderedListItem">INT230-6 contains the chemotherapy drugs cisplatin (Platinol®) and vinblastine (Velban®) along with a substance that makes them more effective.</li> <li class="seamTextUnorderedListItem">This study is also recruiting patients with other types of advanced cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03058289' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://intensitytherapeutics.com/products/lead-product-int230-6/' target='_blank'>Drug Company Information Page: INT230-6</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy/what' target='_blank'>Breastcancer.org: Immunotherapy</a> </li></ul>
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135

NEAREST SITE: 350 miles
Herald Cancer Association
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02946697

A Social Support Program Developed for Chinese-Speaking Breast Cancer Survivors

A Culturally Sensitive Social Support Intervention Scientific Title

Purpose
To look at whether a social support program can help improve quality of life.
Who is this for?
Women who are Chinese speakers (Mandarin or Cantonese) who have been treated for DCIS or stage I, stage II, or stage III breast cancer within the last 3 years. You must also live in or near Los Angeles, California.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Culturally-Based Social Support Program</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education and peer-support program, 7 weeks</li> <li class="seamTextUnorderedListItem">Receive weekly phone calls from peer-mentor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Wait List</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care (no intervention)</li> <li class="seamTextUnorderedListItem">Option to participate in the education and peer-support program after 7 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The program will address topics including treatment-related side effects, symptoms of cancer recurrence, physical therapy and other complementary treatments, stress, depression and other emotional problems, communicating with family members, and body image. </li> <li class="seamTextUnorderedListItem">Each study participant will have the opportunity to establish a relationship with a peer-mentor who is also a Chinese-speaking breast cancer survivor.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02946697' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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136

NEAREST SITE: 353 miles
City Of Hope National Medical Center
Duarte,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT02419417

BMS-986158 for Advanced Triple Negative Breast (and Other) Cancer

A Phase I/IIa Trial With BMS-986158, a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Subjects With Selected Advanced Solid Tumors Scientific Title

Purpose
To investigate whether a new targeted drug for triple negative breast cancer is safe and effective.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following at increasing does until the maximum tolerated dose is reached: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BMS-986158, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The new drug being studied is called BMS-986158. It is currently only available in clinical trials. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of advanced cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02419417' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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137

NEAREST SITE: 353 miles
City of Hope Medical Center
Duarte,CA

VISITS: 2 visits every 3 weeks, ongoing

PHASE: I

NCT ID: NCT02996825

Mirvetuximab Soravtansine & Chemotherapy in FRa+ Metastatic Triple Negative Breast Cancer

A Phase I Dose-Escalation Safety and Tolerability Study of Mirvetuximab Soravtansine (IMGN853) and Gemcitabine in Patients With FRa-positive Recurrent Ovarian, Primary Peritoneal, Fallopian Tube, Endometrial Cancer, or Triple Negative Breast Cancer (TNBC) Scientific Title

Purpose
To test the safety and effects (good and bad) of a new drug called mirvetuximab soravtansine when it is given with the chemotherapy drug gemcitabine (Gemzar®).
Who is this for?
People with stage IV metastatic breast cancer that is triple negative (ER-, PR- and HER2-) and folate receptor (FR) alpha-positive. You must not have had more than four lines of chemotherapy.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mirvetuximab soravtansine, by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Gemcitabine/Gemzar®, by IV, twice every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mirvetuximab soravtansine is an antibody drug conjugate (ADC). </li> <li class="seamTextUnorderedListItem">It uses a drug that targets folate receptors on cancer cells to deliver the chemotherapy drug soravtansine directly to the tumor. </li> <li class="seamTextUnorderedListItem">Gemzar® is a chemotherapy drug approved to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of FR positive tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02996825' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/mirvetuximab-soravtansine' target='_blank'>NCI Dictionary: Mirvetuximab Soravtansine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/gemcitabine-hydrochloride' target='_blank'>NCI Dictionary: Gemcitabine Hydrochloride</a> </li></ul>
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138

NEAREST SITE: 353 miles
City of Hope Comprehensive Cancer Center
Duarte,CA

VISITS: Monthly visits, ongoing

PHASE: II

NCT ID: NCT03012100

Vaccine Therapy and Chemotherapy for Treating Triple Negative Breast Cancer

Double Blind, Parallel Groups, Controlled, Randomized Phase II Trial to Evaluate Vaccination With Folate Receptor Alpha Peptide Vaccine With GM-CSF as Vaccine Adjuvant Following Oral Cyclophosphamide Versus GM-CSF/Placebo to Prevent Recurrence in Patients With Triple Negative Breast Cancer Scientific Title

Purpose
To compare the safety and effects (good and bad) of cyclophosphamide (Cytoxan®) given with a cancer treatment vaccine to Cytoxan given alone.
Who is this for?
Women with triple negative (ER-/PR-/HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®), by mouth, daily (every other week), for 1 month </li> <li class="seamTextUnorderedListItem">followed by FR alpha peptide vaccine with sargramostim, by injection, monthly for 6 months, then every 6 months, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan), by mouth, daily (every other week), for 1 month </li> <li class="seamTextUnorderedListItem">followed by placebo with sargramostim, by injection, monthly, then every 6 months, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FR alpha peptide vaccine is a personalized vaccine that is made by removing some of your white blood cells and mixing them in a lab with tumor proteins. </li> <li class="seamTextUnorderedListItem">The vaccine is a type of immunotherapy. </li> <li class="seamTextUnorderedListItem">This is a treatment that gets your immune cells to fight your cancer. </li> <li class="seamTextUnorderedListItem">All patients will receive sargramostim (GM-CSF) to prevent neutropenia--a low white blood cell count that increases your risk for infection.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03012100' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/immunotherapy/what' target='_blank'>Breastcancer.org: What is Immunotherapy?</a> </li></ul>
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139

NEAREST SITE: 353 miles
City of Hope National Medical Center
Duarte,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03199586

NP-G2-044 in Patients With Advanced Breast Cancer

First-in-Human, Dose Finding, Open Label Phase 1 Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Solid Tumors (Including Lymphoma) Scientific Title

Purpose
To study the safety and best dose of an experimental targeted therapy called NP-G2-044 that binds to a protein called fascin.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that is no longer responding to standard treatment.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NP-G2-044, by mouth, daily (1 month on, 2 weeks off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is investigating the safety and best dose of an experimental targeted therapy called NP-G2-044 that binds to a protein called fascin. </li> <li class="seamTextUnorderedListItem">This study is also enrolling people with other types of advanced and metastatic cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03199586' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/clinical-trials/18-051' target='_blank'>Memorial Sloan Kettering Cancer Center: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793138' target='_blank'>NCI Drug Dictionary: Fascin Inhibitor NP-G2-044</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/medgen/1633753' target='_blank'>MedGen: Fascin Inhibitor NP-G2-044</a> </li></ul>
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140

NEAREST SITE: 353 miles
Site 5
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03560531

Targeted Therapy ZN-c5 For Advanced Breast Cancer

A Phase I Open Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of ZN-c5 Alone and in Combination With Palbociclib in Subjects With Previously Treated Estrogen Receptor Positive, Human Epidermal Growth Factor Receptor-2 Negative Advanced Breast Cancer Scientific Title

Purpose
To look at the safety, best dose and effects (good and bad) of ZN-c5 when it is used alone or in combination with palbociclib (Ibrance®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have already been treated with a hormone therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c5, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c5, by mouth</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c5 is an investigational anti-cancer drug. </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a targeted drug used to treat metastatic breast cancer in combination with a hormone therapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03560531' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/ibrance' target='_blank'>Breastcancer.org: Ibrance</a> </li></ul>
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141

NEAREST SITE: 353 miles
City of Hope Comprehensive Cancer Center
Duarte,CA

VISITS: 1 visit every 3 weeks, for at least 3 months

PHASE: II

NCT ID: NCT03587740

T-DM1 (Kadcyla) in Stage I-III, HER2 Positive Breast Cancer

ATOP TRIAL: Adjuvant Ado-Trastuzumab Emtansine (T-DM1) for Older Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Scientific Title

Purpose
To study the effects (good and bad) and anti-cancer activity of T-DM1 (Kadcyla®).
Who is this for?
People with stage I, stage II, or stage III, HER2 positive (HER2+) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®), by IV, every 3 weeks, for at least 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®) is an antibody-drug conjugate (ADC). </li> <li class="seamTextUnorderedListItem">It uses the HER2-targeted therapy trastuzumab (Herceptin®) to deliver the chemotherapy drug DM1 directly to cancer cells. </li> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®) is approved to treat people with HER2 positive (HER2+) metastatic breast cancer and some people with early-stage HER2 positive (HER2+) breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03587740' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/kadcyla' target='_blank'>Breastcancer.org: Kadcyla (T-DM1)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.kadcyla.com/patient/early-breast-cancer.html' target='_blank'>Genentech Information Page: Kadcyla®</a> </li></ul>
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142

NEAREST SITE: 353 miles
City of Hope Medical Center
Duarte,CA

VISITS: May require hospitalization

PHASE: I

NCT ID: NCT03696030

CAR T-Cell Immunotherapy in HER2 Positive Breast Cancer With Brain or Leptomeningeal Metastases

A Phase 1 Cellular Immunotherapy Study of Intraventricularly Administered Autologous HER2-Targeted Chimeric Antigen Receptor (HER2-CAR) T Cells in Patients With Brain and/or Leptomeningeal Metastases From HER2 Positive Cancers Scientific Title

Purpose
To study the safety, best dose, and effects (good and bad) of a CAR T-cell immunotherapy that is delivered directly into the brain.
Who is this for?
People with metastatic (stage IV) HER2 positive (HER2+) breast cancer that has spread to the brain or to the membranes surrounding the brain and spinal cord (leptomeningeal metastases).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw to collect white blood cells to make your HER2 CAR T-cell therapy (leukapheresis)</li> <li class="seamTextUnorderedListItem">Surgery to place a device (similar to a chemotherapy port) under your scalp</li> <li class="seamTextUnorderedListItem">HER2 CAR T-cells, by injection, weekly, 3 times</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule. Hospital stay may be required.</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Follow up</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Every 2 months for 1 year, then every year for 15 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CAR T-cell therapy is a personalized immunotherapy made from your white blood cells.</li> <li class="seamTextUnorderedListItem">Your blood cells are removed and modified in a lab with chimeric antigen receptors (CARs) so that they can attack a specific protein.</li> <li class="seamTextUnorderedListItem">The CAR T-cells are then infused back into you while you are hospitalized. </li> <li class="seamTextUnorderedListItem">The CAR T-cell therapy being used in this study trains the immune system to attack HER2+ cancer cells.</li> <li class="seamTextUnorderedListItem">You will have surgery to insert a device under your scalp so that the CAR T-cell therapy can be infused directly into your brain.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03696030' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cityofhope.org/physician-news/breast-cancer-car-t-cell-therapy' target='_blank'>City of Hope Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/car-t-cell-therapy' target='_blank'>NCI Dictionary of Cancer Terms: CAR T-cell Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/car-t-cell1.html' target='_blank'>American Cancer Society: CAR T-cell Therapy and Its Side Effects</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Leukapheresis' target='_blank'>Wikipedia: Leukapheresis</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.brainmetsbc.org/content/leptomeningeal-metastases' target='_blank'>BrainMetsBC.org: Leptomeningeal Metastases</a> </li></ul>
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143

NEAREST SITE: 353 miles
City of Hope Medical Center
Duarte,CA

VISITS: 2-3 visits every month, ongoing

PHASE: I-II

NCT ID: NCT03853707

Ipatasertib, Carboplatin and Paclitaxel in Metastatic Triple Negative & ER-Low Breast Cancer

A Phase I/IB Study of Ipatasertib in Combination With Carboplatin or Carboplatin/Paclitaxel in Patients With Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To determine the best dose of ipatasertib (GDC-0068) when it is used along with paraplatin (Carboplatin®) alone or with paraplatin (Carboplatin®) and paclitaxel (Taxol®).
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer that has not responded to standard treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: With Paclitaxel</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, once daily, ongoing</li> <li class="seamTextUnorderedListItem">Paraplatin (Carboplatin®), by IV, 2 or 3 times a month, ongoing</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, 2 or 3 times a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Without Paclitaxel</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, once daily, ongoing</li> <li class="seamTextUnorderedListItem">Paraplatin (Carboplatin®), by IV, 2 or 3 times a month, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Ipatasertib is an investigational targeted therapy that blocks a protein called AKT that helps cancer cells grow and divide. </li> <li class="seamTextUnorderedListItem">Carboplatin and Taxol are chemotherapy drugs used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03853707' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/News/57955' target='_blank'>ASCO Post: AKT Inhibitor Ipatasertib in Metastatic Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/asco-2018/data-support-phase-3-trial-with-akt-inhibitor-in-triple-negative-breast-cancer' target='_blank'>OncLive: Early OS Data Support Phase III Trial With AKT Inhibitor Ipatasertib for TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://academic.oup.com/annonc/advance-article/doi/10.1093/annonc/mdz133/5485241' target='_blank'>Annals of Oncology: Targeting the PI3-kinase pathway in triple-negative breast cancer</a> </li></ul>
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144

NEAREST SITE: 353 miles
City of Hope Medical Center
Duarte,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT04305834

Effects of Abemaciclib in People 70 or Older With Metastatic Hormone Positive Breast Cancer

A Phase IIA Trial Assessing the Tolerability of Abemaciclib Monotherapy in Patients Age 70 and Older With Hormone Receptor Positive Metastatic Breast Cancer Scientific Title

Purpose
To study the side effects (good and bad) of abemaciclib (Verzenio®).
Who is this for?
People with metastatic (stage IV), hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who are age 70 or older and have already received treatment for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®) is a CDK 4/6 inhibitor that is commonly used to treat metastatic, hormone positive (ER+ and/or PR+) breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04305834' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verzenio.com' target='_blank'>Drug Company Information Page: Verzenio® (Abemaciclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/verzenio' target='_blank'>Breastcancer.org: Abemaciclib (Verzenio®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.bcrf.org/blog/breast-cancer-elderly-how-bcrf-researchers-are-treating-growing-patient-population' target='_blank'>Breast Cancer Research Foundation: Breast Cancer in the Elderly</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249663/' target='_blank'>Journal Article: Use of Cyclin-Dependent Kinase 4/6 (CDK4/6) Inhibitors in Older Patients</a> </li></ul>
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145

NEAREST SITE: 353 miles
City of Hope
Duarte,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04348916

ONCR-177 Alone or With Pembrolizumab in Advanced Breast Cancer

A Phase 1, Open-Label, Multicenter, Dose Escalation and Expansion Study of ONCR-177, an Oncolytic Herpes Simplex Virus for Intratumoral Injection, Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors Scientific Title

Purpose
To study the best dose and anti-cancer activity of giving the genetically modified virus ONCR-177 alone and in combination with the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONCR-177, by injection, directly into your tumor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONCR-177, by injection, directly into your tumor</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONCR-177 is an Oncolytic Herpes Simplex Virus--this is a herpes virus that has been genetically modified to destroy cancer cells. Researchers believe it will also work as an immunotherapy.</li> <li class="seamTextUnorderedListItem">ONCR-177 is injected directly into the tumor. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. It gets the immune system to go after cancer cells.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is approved to treat only certain types of breast cancer and its use in this trial is considered experimental. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04348916' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://static1.squarespace.com/static/59df87cbd7bdceb69ad86d5a/t/5ca4c245e5e5f0302a360460/1554301532888/Design+of+ONCR-177+base+vector.pdf' target='_blank'>Drug Company Information Page: ONCR-177</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Oncolytic_herpes_virus' target='_blank'>Wikipedia: Oncolytic Herpes Virus</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda® (Pembrolizumab)</a> </li></ul>
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146

NEAREST SITE: 359 miles
Research Site
Whittier,CA

VISITS: 3 visits a month for at least 6 months

PHASE: III

NCT ID: NCT03997123

Capivasertib & Paclitaxel as First Line Treatment for Advanced Triple Negative Tumors

A Phase III Double-blind Randomised Study Assessing the Efficacy and Safety of Capivasertib/+Paclitaxel vs Placebo+Paclitaxel as First-line Treatment for Patients With Locally Advanced (Inoperable) or Metastatic TNBC. (CapItello290) Scientific Title

Purpose
To compare the effects (good and bad) and effectiveness of paclitaxel (Taxol®) and capivasertib to paclitaxel (Taxol®) and a placebo.
Who is this for?
People who are receiving their first treatment for advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capivasertib, by mouth, 4 times a week, 3 weeks on, 1 week off</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, once a week, 3 weeks on, 1 week off, for at least 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, 4 times a week, 3 weeks on, 1 week off</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, once a week, 3 weeks on, 1 week off, for at least 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy drug that is used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Capivasertib is a targeted therapy drug that blocks Akt.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03997123' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/akt-inhibitor-azd5363' target='_blank'>NCI Drug Dictionary: Capivasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/asco-2019/capivasertib-combined-with-fulvestrant-improves-pfs-in-er-breast-cancer' target='_blank'>Oncolive: Capivasertib Combined With Fulvestrant Improves PFS in ER+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medpagetoday.com/meetingcoverage/asco/80249' target='_blank'>Medpage Today: AKT Inhibitor Doubles PFS in Advanced Breast Cancer</a> </li></ul>
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147

NEAREST SITE: 362 miles
Coast Hematology-Oncology Associates Medical Group
Long Beach,CA

VISITS: Monthly visits for 6 months

PHASE: II

NCT ID: NCT03628066

Ibrance, Ovarian Suppression & Letrozole Before Surgery in Premenopausal Breast Cancer

An Assessment of the Biological and Clinical Effects of Palbociclib (PD 0332991) With Ovarian Suppression and Letrozole in the Neoadjuvant Treatment of Patients With Premenopausal Estrogen-Receptor Positive/HER2-Negative Primary Breast Cancer Scientific Title

Purpose
To look at the safety and effects (good and bad) of giving palbociclib (Ibrance®) and a hormone therapy before surgery to premenopausal women.
Who is this for?
Premenopausal women with estrogen receptor positive, HER2 negative stage II or stage III breast cancer. You must have had a tumor score less than 26 on the OncotypeDX test, and not yet had surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Diagnostic Test: Oncotype DX Breast Recurrence Score</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily for 6 months</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily for 6 months</li> <li class="seamTextUnorderedListItem">Goserelin (Zoladex®), by injection, monthly for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsies: at baseline, after 6 weeks of treatment, and at time of surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ibrance is a type of targeted drug called a CDK inhibitor. It is given along with hormone therapy--either letrozole (Femara®) or fulvestrant (Faslodex®)--to treat breast cancer in postmenopausal women. </li> <li class="seamTextUnorderedListItem">To study the combination in premenopausal women, patients will be given goserelin (Zoladex®), a drug that shuts down the ovaries.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03628066' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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148

NEAREST SITE: 362 miles
Innovative Clinical Research Institute
Whittier,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03858972

Tesetaxel and Capecitabine for Advanced, HER2 Negative, Hormone Positive Breast Cancer

Multinational, Multicenter, Phase 2 Study of Tesetaxel Plus a Reduced Dose of Capecitabine in Patients With HER2 Negative, Hormone Receptor Positive, Locally Advanced or Metastatic Breast Cancer Who Have Not Previously Received a Taxane (CONTESSA 2) Scientific Title

Purpose
To study the anti-cancer activity of tesetaxel when it is given with a reduced dose of capecitabine (Xeloda®).
Who is this for?
People with locally advanced (some stage III) or metastatic (stage IV), hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer not previously treated with a taxane.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel, by mouth, once every 3 weeks</li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, twice a day (2 weeks on, 1 week off)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel is a new type of taxane chemotherapy drug that can be taken by mouth. </li> <li class="seamTextUnorderedListItem">The taxanes that are currently approved are all given intraveneously (IV). </li> <li class="seamTextUnorderedListItem">Xeloda® is an oral chemotherapy drug approved to treat advanced breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03858972' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.odonate.com/tesetaxel' target='_blank'>Odonate Therapeutics Drug Information Page: Tesetaxel</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-7777/capecitabine-oral/details' target='_blank'>WebMD: Capecitabine</a> </li></ul>
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149

NEAREST SITE: 362 miles
Innovative Clinical Research Institute
Whittier,CA

VISITS: Number of visits unavailable, for 5 months

PHASE: II

NCT ID: NCT04075604

Anastrozole & Palbociclib With or Without Nivolumab Before Surgery For People With Stage I-III ER+, HER2- Breast Cancer

Randomized, Non-comparative Neoadjuvant Phase II Study in Patients With ER+/HER2- Breast Cancer >= 2 cm With Safety Run-in, Assessing Nivolumab + Abemaciclib or Palbociclib + Anastrozole Scientific Title

Purpose
To compare the anti-cancer activity, safety, and effects (good and bad) of using nivolumab (Opdivo®), palbociclib (Ibrance®), and anastrozole (Arimidex®) to just palbociclib (Ibrance®) and anastrozole (Arimidex®).
Who is this for?
People with stage I, stage II, or stage III estrogen receptor-positive (ER+), HER2 negative (HER2-) breast cancer who have not yet started treatment. If you are a woman, you must be postmenopausal.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving these drugs before surgery allows researchers to study how they affect breast cancer cells. </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®) is a type of immunotherapy called a PD-1 inhibitor. By blocking PD-1, it helps the immune system see and kill cancer cells. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a type of targeted therapy called a CDK 4/6 inhibitor approved to treat advanced breast cancer. </li> <li class="seamTextUnorderedListItem">Anastrozole (Arimidex®) is a type of hormone therapy called an aromatase inhibitor. It is approved to treat breast cancer in postmenopausal women.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04075604' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://reference.medscape.com/drug/opdivo-nivolumab-999989' target='_blank'>Medscape: Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2018/08/01/mbc-news/' target='_blank'>MetastaticTrialTalk: Update on CDK Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li></ul>
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150

NEAREST SITE: 363 miles
Pacific Shores Medical Group
Long Beach,CA

VISITS: 1 visit weekly

PHASE: I

NCT ID: NCT03800836

Ipatasertib with Atezolizumab & Paclitaxel or Nab-Paclitaxel in Advanced TNBC

A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Ipatasertib in Combination With Atezolizumab and Paclitaxel or Nab-Paclitaxel in Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using ipatasertib in combination with atezolizumab (Tecentriq®) and either paclitaxel (Taxol®) or nab-paclitaxel (Abraxane®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: with Paclitaxel</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily, 3 weeks on, 1 week off</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, once every 2 weeks </li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, 3 weeks on, 1 week off</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: with Nab-Paclitaxel</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily, 3 weeks on, 1 week off</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, once every 2 weeks </li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, weekly, 3 weeks on, 1 week off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib is an investigational targeted therapy that blocks a protein called AKT that helps cancer cells divide and grow. </li> <li class="seamTextUnorderedListItem">Tecentriq is an immunotherapy that is approved for use in combination with Taxol to treat PD-L1-positive advanced triple negative breast cancer. </li> <li class="seamTextUnorderedListItem">Taxol and Abraxane are chemotherapy drugs used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03800836' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2019/04/01/mbc-news-10/' target='_blank'>MetastaticTrialTalk: Tecentriq® (Atezolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biooncology.com/pipeline-molecules/ipatasertib.html' target='_blank'>Drug information page: Ipatasertib</a> </li></ul>
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151

NEAREST SITE: 363 miles
Pacific Shores Medical Group
Long Beach,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT04172597

Poziotinib for Metastatic Breast Cancer with EGFR or HER2 Gene Mutations

A Phase 2 Study of Poziotinib in Patients With EGFR or HER2 Activating Mutations in Advanced Malignancies Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-tumor activity of the experimental targeted therapy poziotinib hydrochloride (HM781-36B).
Who is this for?
People with metastatic (stage IV) breast cancer who have no standard treatment options available. Your tumor must test positive for certain EGFR or HER2 (ERBB2) gene mutations. (See below for complete list of targets or mutations.)    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A biopsy so that your tumor can be tested for certain genetic mutations</li> <li class="seamTextUnorderedListItem">Poziotinib hydrochloride (HM781-36B), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Poziotinib hydrochloride (HM781-36B) is designed to target tumors with certain HER and EGFR related mutations. </li> <li class="seamTextUnorderedListItem">Targets or mutations: HER2 (ERBB2), EGFR, Furin-Like/Extracellular, S310F/Y Transmembrane, I655V, V659E, R678Q, V697L, Exon 20 insertion, T733I, L755X, I767M, D769H/N/Y, V773M, V777L/M, L786V, V842I, T862I, L869R EGFRvIII, R108K, R222C, A289T, P596L, G598V, E709K, G719X, V742I, E746 A750del, S768I, V769M, V774M, R831C, R831H, L858R, L861Q, A864V</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04172597' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nationalbreastcancer.org/breast-cancer-targeted-therapy' target='_blank'>National Breast Cancer Foundation: Targeted Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/poziotinib' target='_blank'>NCI Drug Dictionary: Poziotinib Hydrochloride (HM781-36B)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/targeted-therapy-for-breast-cancer.html' target='_blank'>American Cancer Society: Targeted Therapy for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/23422737' target='_blank'>Journal Abstract: Antitumor activity of HM781-36B, a Pan-HER Tyrosine Kinase Inhibitor, in HER2-amplified Breast Cancer Cells</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/30094493' target='_blank'>Journal Abstract: Activating Human Epidermal Growth Factor Receptor 2 (HER2) Gene Mutation in Bone Metastases From Breast Cancer.</a> </li></ul>
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152

NEAREST SITE: 366 miles
University of California, Los Angeles
Santa Monica,CA

VISITS: At least 1 visit per month

PHASE: II

NCT ID: NCT03207867

Combination Immunotherapies for Advanced Triple Negative Breast Cancer

A Phase 2, Multi-center, Open Label Study of NIR178 in Combination With PDR001 in Patients With Selected Advanced Solid Tumors and Non-Hodgkin Lymphoma Scientific Title

Purpose
To study the safety and effects (good and bad) of using two different types of immunotherapy drugs at the same time to treat advanced triple negative breast cancer.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NIR178, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">PDR001, by IV, monthly, ongoing</li> <li class="seamTextUnorderedListItem">2 biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two experimental immunotherapies being used in this study are NIR178 and PRD001.</li> <li class="seamTextUnorderedListItem">NIR178 is an adenosine receptor antagonist. It blocks adenosine, which is found in the microenvironment that surrounds the tumor. </li> <li class="seamTextUnorderedListItem">PDR001 is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling patients with other types of advanced cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03207867' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/navigating-cancer-care/how-cancer-treated/immunotherapy-and-vaccines/understanding-immunotherapy' target='_blank'>Cancer.net: Understanding Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/pdr001/' target='_blank'>Immuno-Oncology News: PDR001</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.novartis.com/news/media-releases/novartis-continues-grow-immuno-oncology-pipeline-through-collaboration-and' target='_blank'>Novartis: NIR178</a> </li></ul>
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153

NEAREST SITE: 374 miles
St. Joseph Hospital of Orange
Orange,CA

VISITS: Coincides with standard surgery

PHASE: NA

NCT ID: NCT01295723

Radiation Therapy During Surgery for Early-Stage Disease

Intraoperative Boost Radiotherapy With Electrons (IOERT) Followed By Hypofractionated Whole-Breast Irradiation (WBRT) Scientific Title

Purpose
To evaluate the safety and effectiveness of using IOERT in individuals who go on to receive three weeks of whole breast radiation therapy.
Who is this for?
People 40 and older planning to have a lumpectomy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiation therapy with electrons (IOERT) during surgery</li> </ul> <p class="seamTextPara"> Standard whole breast radiation therapy (WBRT) will follow surgery.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy is used following a lumpectomy to destroy any cancer cells that may be left in the breast after surgery. </li> <li class="seamTextUnorderedListItem">It usually consists of 3-5 weeks of daily whole breast radiation therapy, followed by a ®boost® of 5-8 daily radiation treatments targeted directly to the site where the tumor was located. </li> <li class="seamTextUnorderedListItem">Intraoperative radiation therapy with electrons (IOERT) is a new technique that gives intensive radiation therapy during surgery to the area where the tumor was removed.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01295723' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation/types/ext/intraop.jsp' target='_blank'>BreastCancer.org: Intraoperative Radiation</a> </li><li class='seamTextUnorderedListItem'><a href='http://ww5.komen.org/BreastCancer/RadiationTherapy.html' target='_blank'>Susan G. Komen: New Radiation Therapies</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/coping/radiation-therapy-and-you' target='_blank'>NCI Cancer Topics: Radiation Therapy</a> </li></ul>
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154

NEAREST SITE: 374 miles
St. Joseph Hospital of Orange
Orange,CA

VISITS: Coincides with surgery

PHASE: I-II

NCT ID: NCT01688388

Single Dose of Radiation During Surgery for DCIS and Stage I-II Breast Cancer

Single Fraction Intraoperative Radiotherapy With Electrons: An Option in Breast-Conserving Operable Breast Cancer Stages 0, I and II - Prospective, Single-arm Trial Scientific Title

Purpose
To study the safety and effects (good and bad) of giving one dose of radiation therapy during breast cancer surgery instead of many doses of radiation therapy after surgery.
Who is this for?
Women, 40 and older, with DCIS or stage I or stage II breast cancer who will have a lumpectomy (breast conserving surgery) and whose tumor is no larger than 2.5 cm.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT), given after your lumpectomy and sentinel node procedure</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast conserving surgery (lumpectomy) is typically followed by radiation therapy to the breast.</li> <li class="seamTextUnorderedListItem">Radiation therapy is usually given five days a week, for three to six weeks. </li> <li class="seamTextUnorderedListItem">Researchers believe that giving the full dose of radiation therapy in one session during surgery may be as effective as the more typical radiation therapy schedule.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01688388' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/RadiationTherapy.html' target='_blank'>Susan G. Komen: Emerging Areas in Radiation Therapy, Intra-operative radiation therapy</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-treating-radiation' target='_blank'>American Cancer Society: Radiation</a> </li></ul>
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155

NEAREST SITE: 374 miles
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange,CA

VISITS: Weekly visits for 3 months

PHASE: II

NCT ID: NCT02436993

Chemotherapy and a Targeted Therapy Before Surgery for Stage II-III Breast Cancer

A Phase II Study of Breast Cancer Treatment Using Weekly Carboplatin + Paclitaxel With Pertuzumab + Trastuzumab (HER2+) or Bevacizumab (HER2-) in the Neoadjuvant Setting Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of giving chemotherapy with Avastin or Perjeta before surgery and to study whether magnetic resonance imaging (MRI) is a good tool for monitoring and predicting how a tumor will respond to the treatment.
Who is this for?
Women with stage II or stage III breast cancer who have not received prior anti-cancer treatment including surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be assigned to 1 of 2 groups and receive the following treatment for 3 months prior to surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: HER2-negative</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), weekly</li> <li class="seamTextUnorderedListItem">Bevacizumab (Avastin®), every other week</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: HER2-positive</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carbolplain (Paraplatin®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stage II and III tumors may be treated with chemotherapy before surgery. </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) and paclitaxel (Taxol®) are chemotherapy drugs routinely used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Bevacizumab (Avastin®) is a targeted therapy that keeps tumors from growing the blood vessels they need to survive. </li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) are targeted therapies used to treat HER2 positive breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02436993' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://ww5.komen.org/BreastCancer/Neoadjuvant.html' target='_blank'>Susan G. Komen: Neoadjuvant Therapies</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/targeted_therapies/avastin' target='_blank'>BreastCancer.org: Avastin</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/targeted_therapies/herceptin' target='_blank'>BreastCancer.rog: Herceptin</a> </li></ul>
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156

NEAREST SITE: 374 miles
University of California at Irvine Medical Center
Orange,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT04209465

BDTX-189 in Metastatic Breast Cancer That Tests Positive for or Expresses Certain Markers

MasterKey-01: A Phase 1/2, Open-label, Two-part, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics & Antitumor Activity of BDTX-189, an Inhibitor of Allosteric ErbB Mutations, in Patients w/ Advanced Solid Malignancies Scientific Title

Purpose
To study the safety, effects (good and bad), best dose, and anti-cancer activity of the experimental targeted therapy BDTX-189.
Who is this for?
People with metastatic (stage IV) breast cancer whose tumor tests positive or expresses one of several markers. (See below for a list of markers.)    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BDTX-189, by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BDTX-189 targets certain mutations in the ErbB (HER) group of receptor tyrosine kinases. </li> <li class="seamTextUnorderedListItem">People with other types of metastatic breast cancer are also being enrolled in this study.</li> <li class="seamTextUnorderedListItem">Targets or mutations: HER1 (ERBB1), allosteric HER2 (ERBB2), HER3 (ERBB3), EGFR, HER2 exon 20 insertion, HER2 positive, EGFR exon 19 deletion, or L858R</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04209465' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.blackdiamondtherapeutics.com/pipeline/bdtx-189/' target='_blank'>Drug Company Information Page: BDTX-189</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies' target='_blank'>Breastcancer.org: Targeted Therapies</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/25435079' target='_blank'>Article Abstract: Irreversible Multitargeted ErbB Family Inhibitors for Therapy of Lung and Breast Cancer.</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.frontiersin.org/articles/10.3389/fonc.2013.00086/full' target='_blank'>Journal Article: Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment</a> </li></ul>
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157

NEAREST SITE: 386 miles
Loma Linda Medical Center
Loma Linda,CA

VISITS: 2 visits weekly, for 6 weeks

PHASE: NA

NCT ID: NCT03272919

Physical Therapy to Prevent Peripheral Neuropathy in Women with Early-Stage Breast Cancer

Chemotherapy Induced Peripheral Neuropathy (CIPN): A Pilot Study of Intraneural Facilitation for Managing Chemotherapy-Induced Peripheral Neuropathy Scientific Title

Purpose
To study whether a new physical therapy technique called intraneural facilitation can restore blood flow to damaged nerves and reduce the risk of peripheral neuropathy.
Who is this for?
Women who are newly diagnosed with early stage (stage I-III) breast cancer. You must also be planning to receive platinum- and/or taxane-based chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraneural facilitation (physical therapy), twice a week, for 6 weeks</li> <li class="seamTextUnorderedListItem">3 assessments (ultrasound, surveys and questionnaires) over 4.5 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care muscle stretching and strengthening, twice a week, for 6 weeks</li> <li class="seamTextUnorderedListItem">3 assessments (ultrasound, surveys and questionnaires) over 4.5 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You must be planning to receive platinum- and/or taxane-based chemotherapy. This includes carboplatin/Paraplatin® or cisplatin/Platinol® and/or docetaxel/Taxotere® or paclitaxel/Taxol®. </li> <li class="seamTextUnorderedListItem">Intraneural facilitation (INF) is a technique that helps improve blood flow to the nerves by widening tiny openings in nearby arteries. The improved blood flow may stimulate healing and reduce or stop nerve pain.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03272919' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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158

NEAREST SITE: 421 miles
Comprehensive Cancer Centers of Nevada
Las Vegas,NV

VISITS: 2 visit every month, ongoing

PHASE: I

NCT ID: NCT03565445

ASP1948 Immunotherapy For Advanced Breast Cancer

A Phase 1b Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With Nivolumab in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To evaluate the safety and effects of using ASP1948 alone or with nivolumab (Opdivo®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that has not responded to other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ASP1948, by IV, every 2 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ASP1948, by IV, every 2 weeks </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ASP1948 is an investigational immunotherapy that may stimulate an immune response against your cancer cells. </li> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy called a PD-1 (programmed cell death-1) inhibitor. By blocking this protein, immune cells are able to see and kill cancer cells. </li> <li class="seamTextUnorderedListItem">Opdivo is approved to treat certain types of advanced cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This clinical trial is also enrolling patients with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03565445' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/795699' target='_blank'>NCI Drug Dictionary: ASP1948</a> </li></ul>
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159

NEAREST SITE: 421 miles
Comprehensive Cancer Centers of Nevada
Las Vegas,NV

VISITS: 3 visits a month, ongoing

PHASE: II

NCT ID: NCT04225117

Targeted Therapy Enfortumab Vedotin in Advanced, HER2 Negative Breast Cancer

An Open-label, Multicenter, Multicohort, Phase 2 Study to Evaluate Enfortumab Vedotin in Subjects With Previously Treated Locally Advanced or Metastatic Malignant Solid Tumors (EV-202) Scientific Title

Purpose
To study the antitumor activity and effects (good and bad) of the experimental targeted therapy enfortumab vedotin (AGS-22CE).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV), HER2 negative (HER2-) breast cancer who have received chemotherapy for advanced or metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Enfortumab vedotin (ASG-22CE), by IV, weekly (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Enfortumab vedotin (ASG-22CE) is an antibody-drug conjugate. It combines an antibody that targets a specific protein on cancer cells (Nectin-4) with a chemotherapy drug that can kill them.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04225117' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-nectin-4-antibody-drug-conjugate-asg-22ce' target='_blank'>NCI Drug Dictionary: Enfortumab Vedotin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/targeted-cancer-drugs/types/monoclonal-antibodies' target='_blank'>Cancer Research UK: Monoclonal Antibodies</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.seattlegenetics.com/pipeline/enfortumab-vedotin' target='_blank'>Seattle Genetics Drug Information Page: Enfortumab Vedotin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.frontiersin.org/articles/10.3389/fmed.2019.00200/full' target='_blank'>Journal Article: Nectin-4 Expression Is an Independent Prognostic Biomarker and Associated With Better Survival in Triple-Negative Breast Cancer</a> </li></ul>
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160

NEAREST SITE: 426 miles
Research Site
Palm Springs,CA

VISITS: 5 initial visits, then 1 visit every 2 months for 18 months, then 1 visit every 3 months

PHASE: II

NCT ID: NCT03330847

Lynparza Alone or with Ceralasertib in Metastatic Triple Negative Breast Cancer

A Phase II, Open Label, Randomised, Multi-centre Study to Assess the Safety and Efficacy of Agents Targeting DNA Damage Repair in Combination With Olaparib Versus Olaparib Monotherapy in the Treatment of Metastatic Triple Negative Breast Cancer Patients Stratified by Alterations in Homologous Recombinant... (VIOLETTE) Scientific Title

Purpose
To compare the safety and effects (good and bad) of using olaparib (Lynparza®) alone to using olaparib (Lynparza®) in combination with the experimental targeted therapy ceralasertib (AZD6738).
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have received at least one but no more than two lines of chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily</li> <li class="seamTextUnorderedListItem">Ceralasertib (AZD6738), by mouth, once a day (1 week on, 3 weeks off)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">While your tumor will be tested for mutations in genes that are part of the homologous recombination repair (HRR) pathway, which includes BRCA 1/2, a mutation in the HRR pathway is not required for enrollment. </li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of drug called a PARP inhibitor. PARP inhibitors work by blocking the action of poly (ADP-ribose) polymerase, an enzyme that helps repair DNA. It is approved for use in metastatic inherited BRCA1/2 mutation, HER2 negative breast cancer. </li> <li class="seamTextUnorderedListItem">Ceralasertib (AZD6738) is an experimental targeted therapy drug that targets DNA damage repair.</li> <li class="seamTextUnorderedListItem">Targets or mutations: HRR (homologous recombination repair) pathway, BRCA 1, BRCA 2</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03330847' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm592357.htm' target='_blank'>FDA approves olaparib for germline BRCA-mutated metastatic breast cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparza.com/' target='_blank'>AstraZeneca Drug Information Page: Lynparza</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/atr-kinase-inhibitor-azd6738' target='_blank'>NCI Drug Dictionary: Ceralasertib</a> </li></ul>
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161

NEAREST SITE: 428 miles
California Cancer Associates for Research & Excellence, Inc.
Encinitas,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03840200

Ipatasertib With Rucaparib in Advanced HER2 Negative Breast Cancer

A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Ipatasertib in Combination With Rucaparib in Patients With Advanced Breast, Ovarian, or Prostate Cancer Scientific Title

Purpose
To determine the best dose, safety, and effects (good and bad) of ipatasertib when it is used in combination with rucaparib (Rubraca®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer that has not been treated with more than 2 lines of chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib, by mouth, once daily</li> <li class="seamTextUnorderedListItem">Rucaparib, by mouth, twice daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib is an investigational drug that targets Akt, a protein that plays a role in tumor growth. </li> <li class="seamTextUnorderedListItem">Rucaparib is a type of targeted therapy called a PARP inhibitor. It blocks poly (ADP-ribose) polymerase, an enzyme that helps cancer cells grow by repairing their DNA. </li> <li class="seamTextUnorderedListItem">Rucaparib is approved to treat women with certain types of reproductive cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with ovarian and prostate cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03840200' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ipatasertib' target='_blank'>NCI Drug Dictionary: Ipatasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/asco-2018/data-support-phase-3-trial-with-akt-inhibitor-in-triple-negative-breast-cancer' target='_blank'>OncLive: Early OS Data Support Phase III Trial With AKT Inhibitor Ipatasertib for TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.clovisoncology.com/pipeline/rucaparib/' target='_blank'>Drug company information site: Rucaparib</a> </li></ul>
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162

NEAREST SITE: 434 miles
California Cancer Care Associates for Research & Excellence, Inc.
San Marcos,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03251378

Targeted Therapy Fruquintinib for Metastatic HER2 Negative Breast Cancer

A Multi-Center, Open-Label, Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anticancer Activity of Fruquintinib in Patients With Advanced Solid Tumors Scientific Title

Purpose
To study the safety and effects (good and bad) of the experimental targeted therapy fruquintinib.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer who have not already received a VEGFR inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fruquintinib, by mouth, daily (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fruquintinib is a tyrosine kinase inhibitor, a type of targeted therapy, that is designed to block the VEGFR (vascular endothelial growth factor receptor) protein.</li> <li class="seamTextUnorderedListItem">Tumors use VEGFR to grow new blood vessels and research suggests VEGFR inhibitors may slow or stop cancer cell growth. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03251378' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.vicc.org/clinical-trials/protocol-viccgip1965' target='_blank'>Vanderbilt-Ingram Cancer Center Study Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fruquintinib' target='_blank'>NCI Drug Dictionary: Fruquintinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/VEGF_receptor' target='_blank'>Wikipedia: VEGF Receptor</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.drugs.com/drug-class/vegf-vegfr-inhibitors.html' target='_blank'>Drugs.com: What are VEGF/VEGFR inhibitors?</a> </li></ul>
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163

NEAREST SITE: 441 miles
University of California, San Diego
La Jolla,CA

VISITS: Visits weekly over 6 months

PHASE: I

NCT ID: NCT02776917

A New Targeted Therapy and Taxol for Advanced Breast Cancer

A Phase 1b Pilot Clinical Trial of Cirmtuzumab, an Anti-ROR1 Monoclonal Antibody, in Combination With Paclitaxel for the Treatment of Patients With Metastatic, or Locally Advanced, Unresectable Breast Cancer Scientific Title

Purpose
To investigate the safety and effects (good and bad) of a new type of targeted therapy when it is given along with the chemotherapy drug paclitaxel (Taxol®) to treat advanced breast cancer.
Who is this for?
People with triple negative (ER-, PR-, or HER2-) or hormone receptor positive (ER+ or PR+), advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cirmtuzumab, by IV, weekly (2 weeks on, 2 weeks off), over 6 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, ongoing</li> <li class="seamTextUnorderedListItem">Blood and tissue sample collection</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The experimental targeted therapy is cirmtuzumab. It targets ROR1, a protein found only on cancer cells. </li> <li class="seamTextUnorderedListItem">Taxol is commonly used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02776917' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://health.ucsd.edu/news/releases/Pages/2018-08-27-researchers-to-test-novel-drug-combination-against-toughest-breast-cancer.aspx' target='_blank'>UCSD Health Article</a> </li></ul>
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164

NEAREST SITE: 441 miles
Ucsd /Id# 157374
La Jolla,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03000257

ABBV-181: An Immunotherapy Drug for Advanced Breast (and Other Solid) Tumors

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of ABBV-181, a Monoclonal Antibody , in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To look at whether a new type of immunotherapy drug is safe and effective in patients with metastatic or locally advanced breast cancer. The study will also determine the best dose of the drug to use.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) who are no longer responding to available therapies.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-181</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The drug in this study is called ABBV-181. </li> <li class="seamTextUnorderedListItem">ABBV-181 is only available in clinical trials. </li> <li class="seamTextUnorderedListItem">This study has two parts. If you are in the first part, called the dose escalation phase, you can take part if you have already been treated with PD-1/PD-L1 immunotherapy drugs. If you are in the second part, called the dose expansion phase, you cannot have had any PD-1/PD-L1 immunotherapy drugs.</li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03000257' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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165

NEAREST SITE: 441 miles
Moores UCSD Cancer Center
San Diego,CA

VISITS: 1 visit every 3 weeks, ongoing

PHASE: III

NCT ID: NCT03262935

Evaluating a New Targeted Therapy for HER2 Positive Advanced Breast Cancer

A Multi-centre, Open-label, Randomized Clinical Trial Comparing the Efficacy and Safety of the Antibody-drug Conjugate SYD985 to Physician's Choice in Patients With HER2-positive Unresectable Locally Advanced or Metastatic Breast Cancer Scientific Title

Purpose
To compare the safety and effects (good and bad) of a new targeted drug to a physician's choice of standard treatment for advanced HER2+ breast cancer.
Who is this for?
Women with HER2 positive advanced (some stage III) or metastatic (stage IV) breast cancer whose cancer has progressed on two anti-HER2 therapies for locally advanced or metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SYD985, by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Physician's choice treatment (lapatinib/Tykerb®, capecitabine/Xeloda®, trastuzumab/Herceptin®, vinorelbine/Navelbine®, or eribulin/Halaven®)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The new targeted therapy is called SYD985. </li> <li class="seamTextUnorderedListItem">It is an antibody-drug conjugate (ADC). This means it uses an antibody that targets cancer cells to deliver a chemotherapy drug directly to these cells. </li> <li class="seamTextUnorderedListItem">The physician's standard of care drug combination will include two of the following: lapatinib (Tykerb®), capecitabine (Xeloda®), trastuzumab (Herceptin®), vinorelbine (Navelbine®), or eribulin (Halaven®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03262935' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/trastuzumab-duocarmazine-active-in-her2positive-breast-cancer' target='_blank'>OncLive: SYD985</a> </li></ul>
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166

NEAREST SITE: 441 miles
University of California San Diego Medical Center; Moores Cancer Center
La Jolla,CA

VISITS: At least 1 visit every 3 weeks

PHASE: I-II

NCT ID: NCT03424005

Tecentriq & Targeted Therapy or Chemotherapy for Metastatic Triple Negative Breast Cancer

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy And Safety Of Multiple Immunotherapy-Based Treatment Combinations In Patients With Metastatic Triple-Negative Breast Cancer (Morpheus-TNBC) Scientific Title

Purpose
To study the safety and effects (good and bad) of 7 different immunotherapy-based treatment combinations in people with triple negative (ER-/PR-/HER2-) breast cancer.
Who is this for?
People with triple negative (ER-/PR-/HER2-) advanced (some stage III) or metastatic (stage IV) breast cancer that progressed during or following first-line metastatic treatment with chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 7 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth (2 weeks on, 1 week off), ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Ipatasertib (GDC-0068), by mouth, daily (3 weeks on, 1 week off), ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">SGN-LIV1A, by IV, every 3 weeks, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Bevacizumab (Avastin®), by IV, once or twice every 3 weeks, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 5</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Bevacizumab (Avastin®), by IV, once or twice every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Cobimetinib (Cotellic®), by mouth, daily (3 weeks on, 1 week off), ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 6</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, daily (2 weeks on, 1 week off), ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 7</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Physician's choice chemotherapy (gemcitabine/Gemzar® plus carboplatin/Paraplatin®, or eribulin/Halaven®), by IV, weekly (2 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy being used in this study is atezolizumab (Tecentriq®). It is a PD-L1 inhibitor that works by stimulating the body's immune system to go after cancer cells.</li> <li class="seamTextUnorderedListItem">Tecentriq is approved to treat certain types of urinary, bladder and lung cancer.</li> <li class="seamTextUnorderedListItem">The targeted therapies being used in the study are Ipatasertib (GDC-0068), SGN-LIV1A, bevacizumab (Avastin®) and cobimetinib (Cotellic®).</li> <li class="seamTextUnorderedListItem">The chemotherapies being used in this study are capecitabine (Xeloda®), gemcitabine (Gemzar®), carboplatin (Paraplatin®) and eribulin (Halaven®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03424005' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/EmergingMetasticBreastCancer.html' target='_blank'>Komen: Emerging Areas in Metastatic Breast Cancer Treatment</a> </li></ul>
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167

NEAREST SITE: 441 miles
University of CA San Diego
La Jolla,CA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03435640

NKTR-262 and NKTR-214 with or without Opdivo for Advanced TNBC (and Other) Cancers

A Phase 1/2, Open-label, Multicenter, Dose Escalation and Dose Expansion Study of NKTR-262 in Combination With NKTR-214 and in Combination With NKTR-214 Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies (REVEAL) Scientific Title

Purpose
To evaluate the safety and best dose of two experimental immunotherapy drugs when they are given with or without the immunotherapy drug nivolumab (Opdivo®) to treat advanced breast cancer.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that is triple negative breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NKTR-262, by injection, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">NKTR-214, by IV, every 3 weeks, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NKTR-262, by injection, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">NKTR-214, by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks, ongoing</li></ul>
  • <p class="seamTextPara"> INKTR-262 and NKTR-214 are the experimental immunotherapy drugs being used in this study. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy drug called a PD-1 inhibitor. It is approved to treat certain types of metastatic melanoma and non-small cell lung cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03435640' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/web-exclusives/nktr-214-nivolumab-combination-shows-promise-in-early-study' target='_blank'>OncLive: NKTR-214 and Nivolumab</a> </li></ul>
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168

NEAREST SITE: 441 miles
UC San Diego Moores Cancer Center
San Diego,CA

VISITS: 1 visit every 2 weeks, for 2 months

PHASE: I

NCT ID: NCT03752398

XmAb23104 for Advanced Triple Negative Breast Cancer (DUET-3)

A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®23104 in Subjects With Selected Advanced Solid Tumors Scientific Title

Purpose
To study the safety, effects (good and bad) and the best dose of an experimental immunotherapy called XmAb23104.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR-, HER2-) that has not responded to other treatment options.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">XmAb23104, by IV, every 2 weeks, for 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">XmAb23104 targets both PD-1 (programmed cell death protein 1) and ICOS (inducible T-cell co-stimulator). </li> <li class="seamTextUnorderedListItem">This study is enrolling people with other types of metastatic cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03752398' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/796973' target='_blank'>NCI drug dictionary: XmAb23104</a> </li></ul>
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169

NEAREST SITE: 441 miles
UCSD Moores Cancer Center
San Diego,CA

VISITS: Weekly visits for 3 weeks

PHASE: I

NCT ID: NCT03841110

FT500 Alone or With Immunotherapy for Advanced HER2-positive Breast Cancer

FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors (Phase 1) Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of giving FT500 alone or with immunotherapy.
Who is this for?
People with HER2-positive advanced (some stage III) or metastatic (stage IV) breast cancer. Your cancer must have progressed after being treated with nivolumab (Opdivo®), pembrolizumab (Keytruda®) or atezolizumab (Tecentriq®).    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FT500, by IV, weekly, for 3 weeks</li> <li class="seamTextUnorderedListItem">Cyclophosphamide and Fludarabine</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FT500, by IV, weekly for 3 weeks</li> <li class="seamTextUnorderedListItem">Combined with an Immune Checkpoint Inhibitor: Nivolumab (Opdivo®), Pembrolizumab (Keytruda®) or Atezolizumab (Tecentriq®) </li> <li class="seamTextUnorderedListItem">Cyclophosphamide and Fludarabine</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FT500 is a natural killer (NK) cell immunotherapy. </li> <li class="seamTextUnorderedListItem">NK cells are specialized immune cells that can fight cancer cells. </li> <li class="seamTextUnorderedListItem">Cyclophosphamide and fludarabine are chemotherapy drugs used to deplete lymph cells.</li> <li class="seamTextUnorderedListItem">Opdivo, Tecentriq and Keytruda are each a type of immunotherapy drug called a PD-1 (programmed cell death-1) inhibitor. They are approved to treat certain other types of cancers, but their use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03841110' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://health.ucsd.edu/news/releases/Pages/2019-04-01-UC-San-Diego-Health-Treats-Cancer-Patient-with-Stem-Cell-Derived-Natural-Killer-Cells.aspx' target='_blank'>UCSD Health: UC San Diego Health Treats 1st Cancer Patient with Stem-Cell Derived Natural Killer Cells</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.the-scientist.com/news-opinion/clinical-trial-underway-for-a-natural-killer-cell-therapy-65845' target='_blank'>The Scientist: Clinical Trial Underway for a Natural Killer Cell Therapy</a> </li></ul>
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170

NEAREST SITE: 446 miles
UC San Diego
San Diego,CA

VISITS: Visits 5 times a week over 2 months

PHASE: NA

NCT ID: NCT02603341

Proton vs. Photon Radiotherapy for DCIS or Stage I-III Breast Cancer

Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial Scientific Title

Purpose
To compare the safety and effects (good and bad) of photon radiation to proton radiation.
Who is this for?
People with DCIS or stage I, stage II or stage III breast cancer. You must also be between the ages of 21 and 65 and have had a lumpectomy or a mastectomy.    Full eligibility criteria
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  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Photon Therapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">X-ray Radiation (Photon) therapy, 5 times a week, for 5-7 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Proton Therapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Proton radiation therapy, 5 times a week, for 5-7 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Photon radiation therapy is the standard X-ray radiation therapy used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Proton radiation therapy is a type of radiation treatment that delivers radiation more directly to the cancer cells, making it less likely to damage nearby normal tissues. It is often used to treat brain tumors.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02603341' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02603341?term=NCT02603341&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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171

NEAREST SITE: 446 miles
California Protons Cancer Therapy Center
San Diego,CA

VISITS: 10 visits

PHASE: II

NCT ID: NCT01766297

Proton Radiation Therapy For DCIS and Early-Stage Breast Cancer

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer Scientific Title

Purpose
To study the safety, effectiveness, and side effects of proton radiotherapy.
Who is this for?
Women, 50 and older, with DCIS, stage I or stage II breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Proton Radiotherapy, 10 sessions</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation is used after surgery to kill any cancer cells that may have been left in the breast.</li> <li class="seamTextUnorderedListItem">Proton therapy is a form of external beam radiation that uses protons (instead of x-rays) to treat the tumor.</li> <li class="seamTextUnorderedListItem">Because the proton beam can be more directly targeted to the tumor, proton therapy may result in fewer side effects than x-ray radiation.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01766297' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www2.mdanderson.org/cancerwise/2010/03/is-proton-therapy-right-for-you.html' target='_blank'>MD Anderson: Proton therapy</a> </li></ul>
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172

NEAREST SITE: 454 miles
Sharp Memorial Hospital
San Diego,CA

VISITS: At least 4 visits over 1 month

PHASE: I

NCT ID: NCT00986661

PV-10 Chemoablation for Breast Cancer That Has Spread to The Liver

A Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics of PV-10 Chemoablation of Cancer Metastatic to the Liver or Hepatocellular Carcinoma Not Amenable to Resection or Transplant Scientific Title

Purpose
To look at the safety and effects (good and bad) of a PV-10 injection into the liver.
Who is this for?
People with stage IV (metastatic) breast cancer that has spread to the liver.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PV-10, by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Follow up</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visits every 3 months for up to 8 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PV-10 targets and concentrates in tumor cells. </li> <li class="seamTextUnorderedListItem">When used along with radiation, it may make radiation more effective. </li> <li class="seamTextUnorderedListItem">It also may get the immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">This study will also include patients who have liver cancer or who have other types of cancers that have spread to the liver.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00986661' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://provectusbio.com/pv-10-for-cancers-of-the-liver' target='_blank'>Drug company information page: PV-10 For Cancers of the Liver</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pv-10' target='_blank'>NCI Drug Dictionary: PV-10</a> </li></ul>
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173

NEAREST SITE: 533 miles
Oregon Health & Science University
Portland,OR

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03504488

AB-ROR2-ADC for Advanced Breast Cancer

A Phase 1/2 Dose Escalation and Dose Expansion Study of BA3021 in Patients With Advanced Solid Tumors Scientific Title

Purpose
To study the safety and effects (good and bad) of an experimental drug called CAB-ROR2-ADC (BA3021).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that has not responded to standard therapies.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CAB-ROR2-ADC (BA3021) </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CAB-ROR2-ADC is a type of drug called an antibody-drug conjugate (ADC). </li> <li class="seamTextUnorderedListItem">This means it uses an antibody that targets cancer cells to deliver a chemotherapy drug directly to these cells. </li> <li class="seamTextUnorderedListItem">The antibody in this drug targets ROR2 proteins. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03504488' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/794991' target='_blank'>NCI Drug Dictionary: CAB-ROR2-ADC</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/13_Supplement/833' target='_blank'>Cancer Research: Anti-tumor efficacy of BA3021</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.hematologyandoncology.net/archives/april-2017/antibody-drug-conjugates-in-breast-cancer/' target='_blank'>Clinical Advances in Hematology & Oncology: ADC in Breast Cancer</a> </li></ul>
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174

NEAREST SITE: 533 miles
OHSU Knight Cancer Institute
Portland,OR

VISITS: Monthly visits for 1 year

PHASE: II

NCT ID: NCT03801369

Olaparib and Durvalumab in Metastatic Triple Negative & ER-Low Breast Cancer

A Phase II, Open Label, Study of Olaparib and Durvalumab (MEDI4736) in Patients With Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using the combination of olaparib (Lynparza®) and durvalumab (Imfinzi®).
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily for 1 month, then once a month for 1 year</li> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by IV, monthly, for 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2-3 tumor biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Lynparza is a PARP inhibitor. It stops the growth of cancer cells by blocking enzymes called poly ADP ribose polymerase (PARP). </li> <li class="seamTextUnorderedListItem">It is approved to treat certain types of ovarian cancer. </li> <li class="seamTextUnorderedListItem">Imfinzi is a type of immunotherapy drug called a PD-L1 inhibitor. It gets the body's immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">It is approved to treat certain types of lung cancer. </li> <li class="seamTextUnorderedListItem">Preclinical studies suggest this drug combination may be effective in patients with metastatic triple negative breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03801369' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.imfinzi.com/stage-3-nsclc/about/how-imfinzi-works.html?source=imz_c_c_45&umedium=cpc&uadpub=google&ucampaign=2018imfinzidtcnsclcbranded_general&ucreative=branded_alone_ex&uplace=durvalumab&outcome=dtc&cmpid=1' target='_blank'>Durvalumab (Imfinzi®) Drug Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparza.com/ovarian-cancer/recurrent-ovarian-cancer.html?source=lyn_d_c_2&umedium=cpc&uadpub=google&ucampaign=lynparzadtcbranded_alone_2019&ucreative=branded_alone_ex&uplace=olapariblynparza&outcome=dtc&cmpid=1' target='_blank'>Olaparib (Lynparza®) Drug Information Page</a> </li></ul>
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175

NEAREST SITE: 533 miles
OHSU Knight Cancer Institute
Portland,OR

VISITS: Number of visits varies based upon assigned treatment

PHASE: I

NCT ID: NCT03878524

Personalized Medicine For People With Metastatic Breast Cancer (SMMART, Basket Study)

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) Trial Scientific Title

Purpose
To study the safety and effects (good and bad) of having your therapy selected by a group of doctors based on genomic testing of your tumor.
Who is this for?
People with metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Testing of your tumor sample to identify biomarkers</li> <li class="seamTextUnorderedListItem">A combination of two drugs selected from 35 possible drugs</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">This process may be repeated if your disease progresses</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A group of doctors will make a personalized treatment decision for you by studying your tumor's genetic profile (this is called genomic testing).</li> <li class="seamTextUnorderedListItem">The group of doctors will choose 2 drugs out of 35 to give to you. The types of drugs available include: targeted therapies, immunotherapies, and chemotherapies. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of cancer. </li> <li class="seamTextUnorderedListItem">This type of study is called a basket trial.</li> <li class="seamTextUnorderedListItem">Targets or mutations: ABL, BCL2, BRAF, CDK4, CDK6, COX-2, CSF-1R, CTLA-4, EGF, EGFR, FGFR, FLT3, HDAC, HER2 (ERBB2), JAK1/2, KIT, MEK, MET, mTOR, PARP, PD-1, PDGFR, PI3Kdelta, RAF, RET, VEGF, VEGF ligand, VEGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03878524' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ohsu.edu/spatial-systems-biomedicine-center/serial-measurements-molecular-and-architectural-responses' target='_blank'>Oregon Health & Science University: SMMART program</a> </li><li class='seamTextUnorderedListItem'><a href='https://news.ohsu.edu/2018/11/16/making-cancer-clinical-trials-smmart' target='_blank'>Oregon Health & Science University NEWS: Making cancer clinical trials SMMART</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/diagnosis/genomic_assays' target='_blank'>Breastcancer.org: Tumor Genomic Assay Testing</a> </li></ul>
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176

NEAREST SITE: 538 miles
Providence Portland Medical Center
Portland,OR

VISITS: 10 visits over the first 2 months, then monthly visits, ongoing

PHASE: I

NCT ID: NCT03329950

A Study of CDX-1140 as Monotherapy or in Combination in Pati...

A Phase 1 Study of CDX-1140 as Monotherapy or in Combination in Patients With Advanced Malignancies Scientific Title

Purpose
To study the safety, effects (good and bad) and best dose of the experimental cancer drug CDX-1140 when it is used alone or in combination with CDX-301, which is also an experimental cancer drug.
Who is this for?
People with locally advanced (stage III) or metastatic (stage IV) breast cancer and have no other standard treatment options available.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CDX-1140 by IV, every 4 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CDX-1140 by IV, every 4 weeks</li> <li class="seamTextUnorderedListItem">CDX-301 by injection, daily for 5 days per month, for the first 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A pre-treatment and on-treatment biopsy may be required</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CDX-1140 targets a protein called CD40, which is found on cancer cells. </li> <li class="seamTextUnorderedListItem">CDX-301 is a new type of tyrosine-kinase inhibitor. It is also a targeted therapy. </li> <li class="seamTextUnorderedListItem">This study is enrolling patients with other types of solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03329950' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793440' target='_blank'>NCI Dictionary: CDX-1140</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/recombinant-flt3-ligand' target='_blank'>NCI Dictionary: CDX-301</a> </li></ul>
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177

NEAREST SITE: 538 miles
Providence Cancer Institute
Portland,OR

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03602079

A166 for Advanced HER2 Positive and HER2 Low Expression Breast Cancer

A Phase I-II, FIH Study of A166 in Locally Advanced/Metastatic Solid Tumors Expressing Human Epidermal Growth Factor Receptor 2 (HER2) or Are HER2 Amplified That Did Not Respond or Stopped Responding to Approved Therapies Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of the experimental therapy A166.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+) or HER2 low expression breast cancer that has not responded to standard therapies    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A166, by IV </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A166 is a type of drug called an antibody-drug conjugate (ADC).</li> <li class="seamTextUnorderedListItem">A166 combines chemotherapy with a HER2 targeted therapy, allowing it to deliver the chemotherapy directly to the cancer cells. </li> <li class="seamTextUnorderedListItem">HER2 low expression is defined as IHC 1+ or IHC 2+/ISH-</li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03602079' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/795827' target='_blank'>NCI Drug Dictionary: A166</a> </li></ul>
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178

NEAREST SITE: 538 miles
Providence Oncology & Hematology Care Clinic - Eastside
Portland,OR

VISITS: 1 visit every 2 weeks

PHASE: II

NCT ID: NCT03650894

Nivolumab Combined with Ipilimumab and Bicalutamide for HER2 Negative Advanced Breast Cancer

A Phase II Study of Nivolumab Combined With Bicalutamide and Ipilimumab in Metastatic HER2-negative Breast Cancer Scientific Title

Purpose
To test the safety and effects (good and bad) of using a combination of nivolumab (Opdivo®), ipilimumab (Yervoy®), and bicalutamide (Casodex®).
Who is this for?
Women with HER2 negative advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following for up to 2 years: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®), by IV, every 6 weeks</li> <li class="seamTextUnorderedListItem">Bicalutamide (Casodex®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Opdivo® is a type of immunotherapy that gets the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). </li> <li class="seamTextUnorderedListItem">Yervoy is an immunotherapy that works by blocking a protein called CTLA-4. </li> <li class="seamTextUnorderedListItem">Yervoy and Opdivo are approved to be used together to treat patients with melanoma and certain other cancers. Their use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Casodex is an anti-androgen drug used to treat prostate cancer. </li> <li class="seamTextUnorderedListItem">Some breast cancers contain androgen receptors. Laboratory studies suggest these tumors may respond to anti-androgen therapies.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03650894' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ipilimumab' target='_blank'>NCI drug dictionary: Ipilimumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/nivolumab' target='_blank'>NCI drug dictionary: Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/bicalutamide' target='_blank'>NCI drug dictionary: Bicalutamide</a> </li></ul>
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179

NEAREST SITE: 538 miles
Providence Portland Medical Center
Portland,OR

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03957096

SGN-CD47M for Advanced Breast Cancer

A Phase 1 Study of SGN-CD47M in Patients With Advanced Solid Tumors Scientific Title

Purpose
To look at the safety and effects (good and bad) of SGN-CD47M.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer and have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SGN-CD47M, by IV </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This investigational drug is an antibody-drug conjugate. </li> <li class="seamTextUnorderedListItem">These drugs use a targeted therapy to bring a cancer killing drug directly to cancer cells. SGN-CD47M targets CD47. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03957096' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://scopeblog.stanford.edu/2019/03/05/anti-cd47-antibody-trial-in-advanced-cancers-shows-treatment-appears-safe-well-tolerated/' target='_blank'>Stanford Medicine: Anti-CD47 antibody trial in advanced cancers shows treatment appears safe, well-tolerated</a> </li></ul>
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180

NEAREST SITE: 538 miles
Providence Portland Medical Center
Portland,OR

VISITS: 1 visit every 2 weeks, ongoing

PHASE: I

NCT ID: NCT04440943

Immunotherapy CDX-527 for Advanced Breast Cancer

A Phase 1 Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of the experimental immunotherapy CDX-527.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have already received standard of care therapies.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CDX-527, by IV, every 2 weeks, ongonig</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CDX-527 is a drug that has two functions: it bocks PD-1 and also targets CD27. This may activate the immune response more than targeting either PD-1 or CD27 alone. </li> <li class="seamTextUnorderedListItem">CDX-527 is an experimental immunotherapy. This means it is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04440943' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://pubmed.ncbi.nlm.nih.gov/32451681/' target='_blank'>Journal Article Abstract: Development of CDX-527, A Bispecific Antibody Combining PD-1 Clockade and CD27 Costimulation for Cancer Immunotherapy</a> </li></ul>
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181

NEAREST SITE: 602 miles
Huntsman Cancer Institute
Salt Lake City,UT

VISITS: 2 visits over 1 week

PHASE: NA

NCT ID: NCT02317783

Using Brain Imaging to Study the Effect of Chemotherapy on the Brain

Amyloid Plaque Deposition in Chemotherapy-Induced Cognitive Impairment Scientific Title

Purpose
To better understand chemo brain.
Who is this for?
Women with stage I, stage II, or stage II breast cancer who have completed chemotherapy between 6 months and 36 months ago.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will undergo 2 FDG-PET scans using flutemetamol over a week</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Many cancer patients have thinking and memory problems due to cancer or its treatments. </li> <li class="seamTextUnorderedListItem">The reasons for this <q>mental fog</q> referred to as chemo brain are not always known.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02317783' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02317783?term=NCT02317783&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/chemotherapyeffects/chemo-brain' target='_blank'>Cancer.org: Chemo Brain</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm372261.htm' target='_blank'>FDA.gov: Imaging Drug, Flutemetamol</a> </li></ul>
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182

NEAREST SITE: 602 miles
Huntsman Cancer Institute SC
Salt Lake City,UT

VISITS: 1 visit every 3 weeks

PHASE: I

NCT ID: NCT02947165

NIS793 with Spartalizumab (PDR001) in Patients With Advanced Triple Negative Breast Cancer

A Phase I/Ib, Open-label, Multi-center Dose Escalation Study of NIS793 in Combination With PDR001 in Adult Patients With Advanced Malignancies Scientific Title

Purpose
To study the safety, effects (good and bad) and best dose of NIS793 when it is used alone or with an immunotherapy.
Who is this for?
People with locally advanced (stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) and have no other standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NIS793, by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Spartalizumab (PDR001), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">NIS793, by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NIS793 is a targeted therapy that binds to the transforming growth factor-beta receptor. </li> <li class="seamTextUnorderedListItem">Spartalizumab is the investigational immunotherapy being used in this study. It is a type of immunotherapy called a PD-L1 checkpoint inhibitor. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02947165' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/spartalizumab' target='_blank'>NCI Dictionary: Spartalizumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-tgf-beta-monoclonal-antibody-nis793' target='_blank'>NCI Dictionary: NIS793</a> </li></ul>
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183

NEAREST SITE: 602 miles
Huntsman Cancer Institute/University of Utah
Salt Lake City,UT

VISITS: 9 visits over 2 weeks

PHASE: II

NCT ID: NCT03345420

Hypofractionated Radiation for DCIS or Stage I-II Breast Cancer

NOVEMBER (Novem- (9), BrEast Radiation), A Phase II Trial of a 9 Day Course of Whole Breast Radiotherapy for Early Stage Breast Cancer Scientific Title

Purpose
To study the effects (good and bad) of 9 sessions of hypofractionated radiation.
Who is this for?
People with DCIS, stage I, or stage II breast cancer who have had breast cancer surgery and did not have chemotherapy before or after surgery. This study is investigating the effects (good and bad) of 9 sessions of hypofractionated radiation. This type of radiation therapy delivers higher doses of radiation in a fewer number of sessions than standard radiation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following after breast-conserving surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated Radiation Therapy, 9 sessions over 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation delivers higher doses of radiation in a fewer number of sessions than standard radiation.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03345420' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hypofractionated-radiation-therapy' target='_blank'>NCI Dictionary: Hypofractionated radiation therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/benefits-seen-with-shorter-radiation-regimen' target='_blank'>Breastcancer.org: Shorter Radiation Regimen Causes Fewer Side Effects, Offers Better Quality of Life Than Traditional Regimen</a> </li></ul>
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184

NEAREST SITE: 602 miles
Research Site
Salt Lake City,UT

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03616587

AZD9833 With or Without Palbociclib in ER Positive and HER2 Negative Advanced Breast Cancer

A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination With Palbociclib in Women With ER Positive, HER2 Negative Advanced Breast Cancer Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of AZD9833 alone or in combination with palbociclib (Ibrance®).
Who is this for?
Women with ER positive and HER2 negative advanced (some stage III) or metastatic (stage IV) breast cancer that did not respond to standard therapies and has not been treated with more than two different chemotherapy regimens.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD9833</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD9833 </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD9833 is an experimental drug that targets the estrogen receptor and is being developed to treat ER positive, HER2 negative breast cancer. </li> <li class="seamTextUnorderedListItem">Ibrance is a targeted drug used to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">If you are premenopausal, you will also receive a drug that will put you in temporary menopause.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03616587' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/targeted-therapy/palbociclib-ibrance' target='_blank'>BreastCancerResearchUK: Palbociclib</a> </li></ul>
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185

NEAREST SITE: 637 miles
Research Site
Goodyear,AZ

VISITS: Approximately 1 visit a week

PHASE: I-II

NCT ID: NCT03742102

Imfinzi & Taxol with Capivasertib, Danvatirsen or Oleclumab for First Line Metastatic TNBC

A Phase IB/II, 2-stage, Open-label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab (MEDI4736) in Combination With Paclitaxel and Multiple Novel Oncology Therapies and Durvalumab (MEDI4736) + Paclitaxel for First-line Metastatic Triple Negative Breast Cancer. (BEGONIA) Scientific Title

Purpose
To look at the safety and effects (good and bad) of the combination of durvalumab (Imfinzi®) and paclitaxel (Taxol®) when used alone or with one of three additional therapies.
Who is this for?
Women with metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) being treated for the first time for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, 3 weeks on and 1 week off</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, 3 weeks on and 1 week off</li> <li class="seamTextUnorderedListItem">Capivasertib (AZD5363), by mouth, twice a day, 3 weeks on and 1 week off</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, 3 weeks on and 1 week off</li> <li class="seamTextUnorderedListItem">Danvatirsen (AZD9150), by IV, 3 times in the first week and then weekly</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, 3 weeks on and 1 week off</li> <li class="seamTextUnorderedListItem">Oleclumab (MEDI9447), by IV, once every 2 weeks for 1 month, then monthly</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Imfinzi is a type of immunotherapy called a PD-L1 (programmed cell death ligand-1) inhibitor. It has been approved to treat certain types of cancers, and its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Taxol is a chemotherapy drug routinely used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">The three additional therapies are capivasertib, a targeted therapy that blocks Akt; danvatirsen, a targeted therapy that blocks the STAT3 protein; and oleclumab, which targets CD73.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03742102' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/asco-2019/capivasertib-combined-with-fulvestrant-improves-pfs-in-er-breast-cancer' target='_blank'>OncLive: Capivasertib Combined With Fulvestrant Improves PFS in ER+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/stat3-antisense-oligonucleotide-isis-481464' target='_blank'>NCI Drug Dictionary: Danvatirsen</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cd73-monoclonal-antibody-medi9447' target='_blank'>NCI Drug Dictionary: Oleclumab</a> </li></ul>
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186

NEAREST SITE: 650 miles
Mayo Clinic
Phoenix,AZ

VISITS: Weekly visits, for 4 months

PHASE: II

NCT ID: NCT02907918

Ibrance with Femara and Herceptin Before Surgery for Stage II-III ER+ HER2+ Breast Cancer

A Phase II Neoadjuvant Study of Palbociclib in Combination With Letrozole and Trastuzumab as Neoadjuvant Treatment of Stage II-III ER+ HER2+ Breast Cancer (PALTAN) Scientific Title

Purpose
To study the effects (good and bad) of giving Herceptin along with combination therapy of a CDK 4/6 inhibitor and a hormone therapy.
Who is this for?
People with stage II or stage III estrogen receptor positive, HER2 positive breast cancer who have not yet started treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off), for 4 months </li> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily (3 weeks on, 1 week off), for 4 months </li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, weekly, for 4 months </li> <li class="seamTextUnorderedListItem">followed by surgery </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">If you are premenopausal, you will also be given a drug to shut down your ovaries.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The effect of the treatment will be studied by giving the therapy before surgery (neoadjuvant treatment).</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a targeted drug that is used to treat metastatic breast cancer. It is given along with hormone therapy--either letrozole (Femara®) or fulvestrant (Faslodex®).</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) is a HER2-targeted therapy.</li> <li class="seamTextUnorderedListItem">If you are premenopausal, you will also be given a therapy that will stop your ovaries from producing estrogen.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02907918' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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187

NEAREST SITE: 650 miles
Mayo Clinic
Phoenix,AZ

VISITS: At least 1 visit every 3 weeks

PHASE: I-II

NCT ID: NCT03917381

Immunotherapy GEN1046 in Metastatic Triple Negative Breast Cancer

First-in-human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety of GEN1046 in Subjects With Malignant Solid Tumors Scientific Title

Purpose
To find the best dose and study the effects (good and bad) of the experimental immunotherapy GEN1046.
Who is this for?
People with metastatic (stage IV), triple negative (ER-, PR-, HER2-) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive GEN1046, by IV, every 3 weeks</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03917381' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.genmab.com/product-pipeline/products-in-development' target='_blank'>Drug Company Information Page: GEN1046</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2018/10/03/mbc-news-4/' target='_blank'>Metastatic Trial Talk: Immunotherapy & Metastatic Breast Cancer</a> </li></ul>
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188

NEAREST SITE: 650 miles
Mayo Clinic
Phoenix,AZ

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT04301011

Immunotherapy TBio-6517 Alone or With Pembrolizumab for Advanced Triple Negative Breast Cancer

A Phase 1/2a, Multicenter, Open-label Trial of TBio-6517, an Oncolytic Vaccinia Virus, Administered by Intratumoral Injection, Alone and in Combination With Pembrolizumab, in Patients With Advanced Solid Tumors (RAPTOR) Scientific Title

Purpose
To determine the best dose and to study the effects (good and bad) of using the immunotherapy TBio-6517 alone and in combination with the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer. If your tumor is PD-L1 positive, you must have already received a PD-L1 or a PD-1 targeted therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will participate in either Phase 1 or Phase 2: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Phase 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TBio-6517, by injection directly into your tumor, 4 times (you may also receive boosters for up to 2 years)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Phase 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TBio-6517, by injection directly into your tumor, 4 times (you may also receive boosters for up to 2 years)</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TBio-6517 is an immunotherapy that is injected directly into your tumor.</li> <li class="seamTextUnorderedListItem">TBio-6517 is an experimental drug, this means it is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking PD-1. It is approved for use in some cancers but its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04301011' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://turnstonebio.com/#about-us' target='_blank'>Turnstone Biologics Drug Information Page: TBio-6517 (RIVAL-01)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Drug Information Page: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/keytruda-plus-chemo-better-than-chemo-alone-for-some' target='_blank'>Breastcancer.org: Keytruda Plus Chemotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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189

NEAREST SITE: 656 miles
Northwest Medical Specialties
Tacoma,WA

VISITS: At least 1 visit every month, ongoing

PHASE: II-III

NCT ID: NCT04191499

Palbociclib, & Fulvestrant With or Without GDC-0077 in Advanced HR+, HER2- Breast Cancer with a PIK3CA Mutation

A Phase III, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of GDC-0077 Plus Palbociclib and Fulvestrant Versus Placebo Plus Palbociclib and Fulvestrant in Patients With PIK3CA-Mutant, Hormone Receptor-Positive, Her2-Negative, Locally Advanced or Metastatic Breast Cancer Scientific Title

Purpose
To compare the safety, effects (good and bad), and anti-cancer activity of using GDC-0077 with palbociclib (Ibrance®) and fulvestrant (Faslodex®) to using only Ibrance® and Faslodex®.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer that the study investigator finds tests positive for a PIK3CA mutation. You must have received hormone therapy for early stage disease and have not already started treatment for metastatic breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0077, by mouth, daily</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) by injection, once a month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) by injection, once a month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0077 is an experimental targeted therapy that blocks the PI3K pathway.</li> <li class="seamTextUnorderedListItem">Ibrance® is a type of targeted therapy called a CDK4/6 inhibitor. It is used along with a hormone therapy to treat advanced HR positive, HER2 negative breast cancer. </li> <li class="seamTextUnorderedListItem">Faslodex is a hormone therapy used to treat advanced HR positive breast cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04191499' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pi3k-inhibitor-gdc-0077' target='_blank'>NCI Drug Dictionary: GDC-0077</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies' target='_blank'>Breastcancer.org: Targeted Therapies for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/publications/cure/2019/breast-2019/a-brighter-outlook-for-metastatic-breast-cancer' target='_blank'>Cure Today: A Brighter Look for Metastatic Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com/about-ibrance?src_code=IBRW10028851#faq' target='_blank'>Pfizer Oncology: Ibrance® (Palbociclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/fda-expands-use-of-faslodex-for-bc' target='_blank'>Breastcancer.org: FDA Expands Use of Faslodex for Breast Cancer</a> </li></ul>
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190

NEAREST SITE: 660 miles
Mayo Clinic - Scottsdale
Scottsdale,AZ

VISITS: Number of visits unavailable, over 4 months

PHASE: II

NCT ID: NCT01723774

PD 0332991 & Arimidex Before Surgery for ER+, HER2- Tumors

A Phase II Trial of Neoadjuvant PD 0332991, a Cyclin-Dependent Kinase (Cdk) 4/6 Inhibitor, in Combination With Anastrozole in Women With Clinical Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast Cancer Scientific Title

Purpose
To study the safety and effectiveness of giving PD 0332991 along with Arimidex before surgery.
Who is this for?
Women with stage II or stage III estrogen receptor positive (ER+), HER2 negative breast cancer. To be eligible for this trial, patients must have pre-registered for the NCI 9170 trial and then have been told they were not able to enroll because they did not have a PIK3CA hotspot mutation.    Full eligibility criteria
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  • <p class="seamTextPara"> All participants will receive the following prior to surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PD 0332991 by mouth, daily 3 weeks per month for 4 months</li> <li class="seamTextUnorderedListItem">Anastrozole by mouth, daily for 4 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PD 0332991 (palbociclib isethionate) is a new oral drug that works by blocking a family of enzymes that control cell division. </li> <li class="seamTextUnorderedListItem">Anastrozole (Arimidex®) is used routinely to treat hormone-sensitive tumors. </li> <li class="seamTextUnorderedListItem">Giving anti-cancer medications before surgery (neoadjuvant treatment) allows researchers to see how the tumor responds to the drugs being studied.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01723774' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/drugdictionary?cdrid=454586' target='_blank'>NCI Drug Dictionary: Palbociclib isethionate</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted' target='_blank'>NCI: Targeted therapy</a> </li><li class='seamTextUnorderedListItem'><a href='http://finance.yahoo.com/news/pfizer-palbociclib-pd-0332991-receives-120000060.html' target='_blank'>Yahoo Finance: Palbociclib</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors/arimidex' target='_blank'>BreastCancer.org: Arimidex</a> </li></ul>
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191

NEAREST SITE: 660 miles
Mayo Clinic in Arizona
Scottsdale,AZ

VISITS: 1 visit weekly, ongoing

PHASE: II

NCT ID: NCT03179904

TVB-2640 with Taxol and Herceptin for Advanced, HER2 Positive Breast Cancer

Phase II Trial to Evaluate the Efficacy of the FASN Inhibitor, TVB-2640, in Combination With Paclitaxel and Trastuzumab in Patients With HER2+ Metastatic Breast Cancer Resistant to Trastuzumab and Taxane-Based Therapy Scientific Title

Purpose
To look at the safety and effects (good and bad) of using a new targeted therapy along with both chemotherapy and a HER2-targeted therapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV), HER2 positive (HER2+) breast cancer. Your cancer must have progressed after receiving trastuzumab (Herceptin®) and pertuzumab (Perjeta®) and you must have also already received a taxane-based chemotherapy.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TVB-2640, by mouth, daily, ongoing </li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, ongoing </li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, weekly, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The new targeted therapy used in this study is TVB-2640. It stops cancer cells from growing by targeting a protein called FASN. </li> <li class="seamTextUnorderedListItem">The chemotherapy drug used in this study is paclitaxel (Taxol®). </li> <li class="seamTextUnorderedListItem">The HER2-targeted drug is trastuzumab (Herceptin®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03179904' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.3vbio.com' target='_blank'>Drug Company Information Page: TVB-2640</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fasn-inhibitor-tvb-2640' target='_blank'>NCI Drug Dictionary: TVB-2640</a> </li></ul>
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192

NEAREST SITE: 660 miles
Mayo Clinic in Arizona
Scottsdale,AZ

VISITS: Daily visits for 5 days, followed by surgery in 1-4 months

PHASE: II

NCT ID: NCT03624478

Hypofractionated Radiation Therapy For Stage I-II Breast Cancer Before Surgery

A Pilot/Phase II Trial of Hypofractionated Radiotherapy to the Whole Breast Alone Before Breast Conserving Surgery Scientific Title

Purpose
To look at the effects of hypofractionated radiation has on a breast tumor when it is given before surgery.
Who is this for?
People with stage I through stage IIA breast cancer, not have had any other cancer treatments, and be scheduled to have surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy, daily for 5 days</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care surgery 1-4 months after radiation therapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is looking to see if hypofractionated radiation therapy delivers higher doses of radiation therapy than standard radiation therapy in fewer sessions. </li> <li class="seamTextUnorderedListItem">Giving the therapy before surgery allows the researchers to see how it affects the tumor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03624478' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hypofractionated-radiation-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Hypofractionated radiation therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://moffitt.org/newsroom/press-release-archive/2017/radiation-therapy-prior-to-surgery-reduces-the-risk-of-secondary-tumors-in-early-stage-breast-cancer-patients/' target='_blank'>Moffit Cancer Center: Radiation Therapy Prior to Surgery Reduces the Risk of Secondary Tumors in Early-Stage Breast Cancer Patients</a> </li></ul>
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193

NEAREST SITE: 666 miles
University of Washington Medical Center
Seattle,WA

VISITS: 1 visit

PHASE: II

NCT ID: NCT02398773

Predicting Which People With Newly Diagnosed Metastases Will Respond to Hormone Therapy

[18F] Fluoroestradiol (FES) PET as a Predictive Measure for Endocrine Therapy in Patients With Newly Diagnosed Metastatic Breast Cancer (EAI142) Scientific Title

Purpose
To see if FES-PET/CT scans can be used to predict how well a patient with newly diagnosed, ER+ breast cancer that has spread to other parts of the body will respond to standard hormone therapy.
Who is this for?
People with newly diagnosed metastatic (stage IV) breast cancer who have not yet received hormone therapy for advanced disease.    Full eligibility criteria
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  • <p class="seamTextPara"> All participants will undergo the following up to 30 days before starting standard hormone therapy: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FES tracer, by IV over 2 minutes</li> <li class="seamTextUnorderedListItem">followed by PET/CT imaging</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">May undergo a second FES-PET/CT at least 24 hours and no later than 10 days after the initial study</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tracers are chemicals that are used to find cancer cells in the body. </li> <li class="seamTextUnorderedListItem">Fluoroestradiol (FES) is a tracer that can find estrogen receptors in breast tumors. </li> <li class="seamTextUnorderedListItem">Giving an FES tracer before a PET/CT scan may help doctors find ER+ breast cancer cells that have spread to other parts of the body (metastasized).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02398773' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://clincancerres.aacrjournals.org/content/23/2/407' target='_blank'>AACR: Estrogen Receptor Binding and Glycolytic Activity Predict Progression-Free Survival on Endocrine Therapy</a> </li></ul>
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194

NEAREST SITE: 666 miles
University of Washington Medical Center
Seattle,WA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02993068

Stand up to Cancer: Making Genetic Testing Accessible

Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible) Scientific Title

Purpose
To study four approaches to providing education about genetic risk for cancer.
Who is this for?
Women, age 30 or over, with at least one ovary, a history of breast cancer or considered at high risk for breast cancer, and planning to be tested for a breast cancer-related genetic mutation.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Watch an online educational video before the testing</li> <li class="seamTextUnorderedListItem">Mail in the saliva collection kit </li> <li class="seamTextUnorderedListItem">Receive an online test results report</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Watch an online educational video before the genetic testing </li> <li class="seamTextUnorderedListItem">Mail in the saliva collection kit </li> <li class="seamTextUnorderedListItem">Receive an online test results report with telephone genetic counseling</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Watch an online educational video with telephone genetic counseling before the testing</li> <li class="seamTextUnorderedListItem">Mail in the saliva collection kit </li> <li class="seamTextUnorderedListItem">Receive an online test results report with telephone genetic counseling </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Watch an online educational video with telephone genetic counseling before the testing</li> <li class="seamTextUnorderedListItem">Mail in the saliva collection kit </li> <li class="seamTextUnorderedListItem">Receive an online test results report</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The researchers will see what effects the programs have on a woman's understanding of genetics and quality of life.</li> <li class="seamTextUnorderedListItem">The study is using FDA-approved saliva-testing kits and genetic tests.</li> <li class="seamTextUnorderedListItem">To be eligible for this study, you must meet one of the following: diagnosed with breast cancer at 45 or younger; diagnosed with triple negative (ER-, PR-, HER2-) breast cancer at 60 or younger; have one blood relative with a mutation in BRCA 1, BRCA 2, BRIP1, PALB2, RAD51C, RAD51D, BARD1, MSH2, MSH6, MLH1, or PMS2; have one relative with ovarian cancer; have at least 2 relatives with breast cancer on the same side of the family, one of which is 50 years of age or less; or have one male relative with breast cancer.</li> <li class="seamTextUnorderedListItem">Any woman who tests positive for a genetic mutation will have the ability to speak with a genetic counselor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02993068' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://magenta.mdanderson.org' target='_blank'>MD Anderson Cancer Center Study Information: MAGENTA</a> </li></ul>
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195

NEAREST SITE: 671 miles
Banner MD Anderson Cancer Center
Gilbert,AZ

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03901469

ZEN003694 and Talazoparib for Triple Negative & ER-Low Breast Cancer

A Phase 2 Study of ZEN003694 in Combination With Talazoparib in Patients With Triple-Negative Breast Cancer Scientific Title

Purpose
To look at the safety and effects (good and bad) of using the experimental drug ZEN003694 along with talazoparib (Talzenna®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer who have been tested for and found to not have inherited a BRCA1 or BRCA2 mutation    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZEN003694, by mouth, once daily </li> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, once daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">ZEN003694 is a drug taken by mouth that targets the protein BET. </li> <li class="seamTextUnorderedListItem">This protein helps cancer cells grow. </li> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®) is a PARP inhibitor. </li> <li class="seamTextUnorderedListItem">It prevents the PARP protein from repairing damaged DNA inside tumor cells. </li> <li class="seamTextUnorderedListItem">It is approved to treat HER2-negative locally advanced or metastatic breast cancer in people with an inherited BRCA mutation.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03901469' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-approves-talazoparib-for-brcamutated-her2negative-breast-cancer' target='_blank'>OncLive: FDA Approves Talazoparib for BRCA-Mutated, HER2-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/bet-bromodomain-inhibitor-zen-3694' target='_blank'>NCI Drug Dictionary: BET bromodomain inhibitor ZEN-3694</a> </li></ul>
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196

NEAREST SITE: 671 miles
Banner MD Anderson Cancer Center
Gilbert,AZ

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04115306

Targeted Therapy PMD-026 for Metastatic Triple Negative Breast Cancer

Phase 1/1b Multicenter, Open-Label, First-in-Human Dose Escalation and Dose Expansion Study to Assess Safety and Tolerability of Orally Administered PMD-026 in Patients With Metastatic Breast Cancer With Expansion in Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To determine the best dose, safety, and effects of the drug PMD-026.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer with no standard treatment options.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PMD-026, by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PMD-026 is an experimental therapy that targets RSK2, a protein that plays a role in cancer cell growth.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04115306' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://phoenixmd.ca/pipeline' target='_blank'>Drug Company Information Page: PMD-026</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/29498411' target='_blank'>PubMed Abstract: RSK1 Promotes Murine Breast Cancer Growth and Metastasis</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Ribosomal_s6_kinase' target='_blank'>Wikipedia: RSK</a> </li></ul>
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197

NEAREST SITE: 680 miles
Swedish Cancer Institute
Seattle,WA

VISITS: 1 visit

PHASE: NA

NCT ID: NCT02701244

Breast Seed Implant Radiation Treatment for Women with DCIS or Early-Stage Breast Cancer

A Multicenter Registry Study of Breast Microseed Treatment for Early Stage Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of a permanent breast seed implant (PBSI) radiation technique for treating women with DCIS or early-stage breast cancer.
Who is this for?
Women who are at least 50 years of age and who have recently had a lumpectomy for DCIS or stage I, stage II, or stage III breast cancer. You must also have had either an axillary node dissection or sentinel lymph node biopsy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pre-planning of implantation using CT scan </li> <li class="seamTextUnorderedListItem">Permanent breast seed implantation, an out-patient procedure using local anesthesia and light sedation</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PBSI involves implanting radioactive seeds in a portion of the breast, allowing the patient to live a normal life while the seeds deliver the prescribed radiation to the breast. </li> <li class="seamTextUnorderedListItem">Researchers think that PBSI is a safe and effective alternative to traditional forms of radiation for women who have had a lumpectomy and lymph node dissection or sentinel lymph node biopsy.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02701244' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/radiation/internal-radiation-therapy-brachytherapy.html' target='_blank'>Cancer.gov: Internal Radiation Therapy</a> </li></ul>
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198

NEAREST SITE: 682 miles
Fred Hutch/University of Washington Cancer Consortium
Seattle,WA

VISITS: 7 visits over 15 months

PHASE: I

NCT ID: NCT02157051

A Vaccine for Treating Advanced, HER2 Negative Breast Cancer

A Phase I Trial of the Safety and Immunogenicity of a Multiple Antigen Vaccine (STEMVAC) in HER2 Negative Advanced Stage Breast Cancer Patients Scientific Title

Purpose
To study the effects (good and bad) and best dose of the new STEMVAC vaccine.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV), HER2 negative (HER2-) breast cancer. You must have either no evidence of cancer or metastasis to bone only.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">STEMVAC vaccine, by injection, every month for 3 months, and at 6 and 12 months</li> <li class="seamTextUnorderedListItem">Follow up visits during months 4 and 15</li></ul>
  • <p class="seamTextPara"> Vaccines made from DNA from tumor cells may help the body build an effective immune response to the cancer. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A new vaccine called STEMVAC is designed to target a protein on breast cancer stem cells that is resistant to chemotherapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02157051' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.historyofvaccines.org/content/articles/cancer-vaccines-and-immunotherapy' target='_blank'>The College of Physicians of Philadelphia: Cancer Vaccines and Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='http://sharedresources.fredhutch.org/profile/disis-nora' target='_blank'>Lead Researcher: Dr. Nora Disis</a> </li><li class='seamTextUnorderedListItem'><a href='https://depts.washington.edu/tumorvac/clinical-trials/breast-cancer/protocol-137' target='_blank'>University of Washington Medicine Cancer Vaccine Institute: Study website</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2018/10/03/mbc-news-4/' target='_blank'>MetastaticTrialTalk.org: Immunotherapy & Metastatic Breast Cancer</a> </li></ul>
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199

NEAREST SITE: 682 miles
Fred Hutch/University of Washington Cancer Consortium
Seattle,WA

VISITS: 2-3 visits over 1-2 months; may include hospital stay

PHASE: I

NCT ID: NCT02706392

CAR T-Cell Therapy For Metastatic Triple Negative & ER-Low Breast Cancer that is ROR1 Positive

Phase I Study of Adoptive Immunotherapy for Advanced ROR1+ Malignancies With Defined Subsets of Autologous T Cells Engineered to Express a ROR1-Specific Chimeric Antigen Receptor Scientific Title

Purpose
To assess the safety, effects (good and bad) and best dose of an experimental CAR-T immunotherapy that targets cancer cells that test positive for ROR1.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer that has not responded to other treatment options and that tests positive for ROR1.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leukapheresis (blood draw for the collection of cells) </li> <li class="seamTextUnorderedListItem">Chemotherapy (cyclophosphamide and fludarabine), 1 or 2 times over 3 weeks</li> <li class="seamTextUnorderedListItem">ROR1 CAR-T cells, by IV, 1 or 2 times over 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Hospital stay may be required</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">CAR-T is a personalized immunotherapy made from a patient's white blood cells. </li> <li class="seamTextUnorderedListItem">The blood cells are removed from the patient and then modified with chimeric antigen receptors (CARs) so they can attack specific proteins. The cells are then infused back into the patient in the hospital. </li> <li class="seamTextUnorderedListItem">The CAR-T therapy being used in this study trains the immune system to attack ROR1-positive tumor cells. </li> <li class="seamTextUnorderedListItem">It is given along with the chemotherapy drugs fludarabine phosphate and cyclophosphamide. These drugs are given to deplete lymph cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of ROR1-positive metastatic tumors.</li> <li class="seamTextUnorderedListItem">Targets or mutations: ROR1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02706392' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertherapyadvisor.com/sabcs-2018/cart-trial-triple-negative-breast-cancer-start-tnbc/article/819085/' target='_blank'>Cancer Therapy Advisor: CAR-T Trial for Triple-Negative Breast Cancer Under Way</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.drsusanloveresearch.org/videos/chimeric-antigen-receptor-t-cell-car-t-therapy' target='_blank'>Dr. Susan Love Research Foundation: Chimeric Antigen Receptor T-Cell (CAR-T) Therap</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/26874851' target='_blank'>Pubmed: Expression of ROR1 has prognostic significance in triple negative breast cancer.</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.abstracts2view.com/sabcs18/view.php?nu=SABCS18L_1227' target='_blank'>SABCS 2018 Abstract: Trial update (ROR1-CAR)</a> </li></ul>
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200

NEAREST SITE: 682 miles
Investigational Site Number 8400001
Seattle,WA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03284957

SAR439859 with Ibrance in Postmenopausal Women with ER+, HER2- Advanced Breast Cancer

A Phase 1/2 Study for the Safety, Efficacy, Pharmacokinetic and Pharmacodynamics Evaluation of SAR439859, Administered Orally as Monotherapy, Then in Combination With Palbociclib in Postmenopausal Women With Estrogen Receptor-positive Advanced Breast Cancer Scientific Title

Purpose
To determine the best dose, safety and effects (good and bad) of SAR439859 when it is given alone or in combination with palbociclib (Ibrance®).
Who is this for?
Postmenopausal women with estrogen receptor positive, HER2 negative, advanced (some stage III) or metastatic (stage IV) breast cancer . You must have received prior treatment for advanced breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SAR439859, by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SAR439859, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SAR439859 is an experimental anti-estrogen drug. It is available only in clinical trials. </li> <li class="seamTextUnorderedListItem">Ibrance® is a targeted therapy that blocks the CDK4/6 protein. It is approved to treat postmenopausal women with ER+, HER2- metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03284957' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/77/4_Supplement/P3-04-05' target='_blank'>Cancer Research: SAR439859</a> </li></ul>
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201

NEAREST SITE: 682 miles
University of Washington, Fred Hutchinson Cancer Research Center
Seattle,WA

VISITS: Weekly visits for 6-7 weeks, then every 3 months for 6 months

PHASE: II

NCT ID: NCT03384914

Vaccine to Prevent Recurrence in Early Stage HER2+ Breast Cancer

A Multicenter Phase II Study of Vaccines to Prevent Recurrence in Patients With HER-2 Positive Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of two different vaccines, either dendritic cell vaccines or WOKVAK vaccine.
Who is this for?
People with stage I, stage II, or stage III HER2 positive breast cancer that was treated with chemotherapy and a HER2 targeted therapy before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dendritic cell vaccine, by injection, weekly, for 6 weeks </li> <li class="seamTextUnorderedListItem">Followed by 3 booster vaccines, 6 months after receiving the first vaccine, every 3 months </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">WOKVAC vaccine, by injection, every 3 weeks for 7 weeks </li> <li class="seamTextUnorderedListItem">Followed by 3 booster vaccines, 6 months after receiving the first vaccine, every 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers think vaccines will stimulate the immune system in ways that will help reduce your risk of a breast cancer recurrence.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03384914' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/whats-new-in-immunotherapy-research.html' target='_blank'>Cancer.org: What's New in Cancer Immunotherapy Research?</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.wingsofkaren.org/dr-king---dr-disis' target='_blank'>Wings of Karen: WOKVAC Vaccine</a> </li></ul>
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202

NEAREST SITE: 682 miles
University of Washington Seattle Cancer Center
Seattle,WA

VISITS: At least 1 visit every 2 months

PHASE: I-II

NCT ID: NCT03997968

CYT-0851 for Advanced Solid Tumors and Some Types of Blood Cancers

A Multi-Center, Open Label Phase 1/2 Study of CYT-0851, an Oral RAD51 Inhibitor, in Patients With Relapsed/Refractory B-Cell Malignancies and Advanced Solid Tumors Scientific Title

Purpose
To study the safety and best dose of CYT-0851, a type of targeted therapy called a RAD51 inhibitor.
Who is this for?
People with triple negative (ER-, PR-, HER2-) metastatic (stage IV) breast cancer that tests positive for a protein called activation-induced cytidine deaminase (AID).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CYT-0851, by mouth, ongoing</li> <li class="seamTextUnorderedListItem">1 biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RAD51 is a protein that helps cells repair DNA damage. Blocking this process may keep tumors from growing. </li> <li class="seamTextUnorderedListItem">Tumors that test positive for a protein called activation-induced cytidine deaminase (AID) may have high rates of DNA damage. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling patients with other types of cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03997968' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancernetwork.com/breast-cancer/rad51-linked-parp-inhibitor-resistance-brca-mutated-breast-cancer' target='_blank'>CancerNetwork.com: RAD51</a> </li></ul>
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203

NEAREST SITE: 682 miles
Fred Hutchinson Cancer Research Center
Seattle,WA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04020575

CAR T-Cell Immunotherapy for Metastatic Breast Cancer That Tests Positive for MUC 1*

Adoptive Immunotherapy for Advanced MUC1* Positive Breast Cancer With Autologous T Cells Engineered to Express a Chimeric Antigen Receptor, huMNC2-CAR44 Specific for a Cleaved Form of MUC1 (MUC1*) Scientific Title

Purpose
To look at the safety, best dose and effects of an experimental CAR T-cell immunotherapy that targets cancer cells that test positive for MUC1*, a special type of the MUC1 protein.
Who is this for?
People with metastatic (stage IV) breast cancer that tests positive for MUC1 and who have already received at least one standard therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw to collect white blood cells to make your personalized CAR T-cell therapy (leukapheresis)</li> <li class="seamTextUnorderedListItem">Chemotherapy to deplete your lymph cells</li> <li class="seamTextUnorderedListItem">huMNC2-CAR44 CAR T-cells, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule. Hospital stay may be required.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CAR T-cell therapy is a personalized immunotherapy made from your white blood cells. </li> <li class="seamTextUnorderedListItem">Your blood cells are removed and modified in a lab with chimeric antigen receptors (CARs) so that they can attack a specific protein. </li> <li class="seamTextUnorderedListItem">The CAR T-cells are then infused back into you while you are hospitalized </li> <li class="seamTextUnorderedListItem">The CAR T-cell therapy being used in this study trains the immune system to attack MUC1 on cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04020575' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/treatment-options/car-t-cell-therapy.html' target='_blank'>MD Anderson Cancer Center: CAR T-Cell Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/research/car-t-cells' target='_blank'>NCI: Car T-Cells</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.minervabio.com/clinical-trial-humnc2-car44-in-mbc/' target='_blank'>Minerva Biotechnologies: Study Page</a> </li></ul>
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204

NEAREST SITE: 682 miles
Fred Hutch/University of Washington Cancer Consortium
Seattle,WA

VISITS: 1 visit every 3 weeks

PHASE: I

NCT ID: NCT04120246

Alpha-TEA and Trastuzumab for Metastatic HER2 Positive Breast Cancer

A Phase I Dose Escalation Trial of Alpha-Tocopheryloxyacetic Acid (α-TEA) in Patients With Treatment Refractory HER2+ Metastatic Breast Cancer Scientific Title

Purpose
To study the best dose and effects (good and bad) of giving alpha-TEA in combination with trastuzumab (Herceptin®).
Who is this for?
People with metastatic (stage IV) HER2 positive (HER2+) breast cancer who have already received trastuzumab (Herceptin®), pertuzumab (Perjeta®), and trastuzumab emtansine (TDM-1) for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpha-TEA, by mouth, daily (2 weeks on, 2 weeks off), ongoing</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">You will also receive your doctor's choice of hormone therapy if your tumor is hormone positive</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpha-TEA is a drug derived from vitamin E.</li> <li class="seamTextUnorderedListItem">Alpha-TEA may stimulate the immune system to fight cancer cells.</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) is commonly used to treat people with metastatic HER2 positive breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04120246' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/alpha-tocopheryloxyacetic-acid' target='_blank'>NCI Drug Dictionary: Alpha-Tocopheryloxyacetic Acid (Alpha-TEA)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/herceptin' target='_blank'>Breastcancer.org: Trastuzumab (Herceptin®)</a> </li></ul>
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205

NEAREST SITE: 682 miles
Site 5
Seattle,WA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04176757

ZN-C5 for Stage I, II, III, and IV ER+, HER2- Breast Cancer

A Phase 1 Open-Label, Multicenter Study to Evaluate Biomarkers for ZN-c5 in Subjects With Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Scientific Title

Purpose
To determine the best dose of the investigational drug ZN-c5.
Who is this for?
People with stage I, stage II, stage III, or stage IV (metastatic) estrogen positive (ER+), HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c5, by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c5 is a type of hormone therapy called a SERD (selective estrogen receptor degrader).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04176757' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.zentalis.com/#pipeline' target='_blank'>Drug Company Information Page: ZN-C5</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Selective_estrogen_receptor_degrader' target='_blank'>Wikipedia: Selective Estrogen Receptor Degrader (SERD)</a> </li></ul>
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206

NEAREST SITE: 741 miles
University of Arizona
Tucson,AZ

VISITS: 2 visits within 2 months

PHASE: NA

NCT ID: NCT03661892

Syndros to Reduce Pain from Bone Metastases in Stage IV Breast Cancer

Title A Pilot Trial to Evaluate Syndros in Decreasing Opioid Requirement in Patients With Bone Metastases From Breast Cancer Scientific Title

Purpose
To identify the best dose and side effects (good and bad) of Syndros (dronabinol) when used to treat pain from bone metastasis.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the bone and have been taking an opioid for bone pain for at least 4 weeks.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Syndros (Dronabinol), by mouth, daily, for 2 months</li> <li class="seamTextUnorderedListItem">Blood and urine samples</li> <li class="seamTextUnorderedListItem">Questionnaires</li> <li class="seamTextUnorderedListItem">Weekly calls</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Syndros is an FDA-approved cannabinoid. </li> <li class="seamTextUnorderedListItem">Cannabinoids are the active chemicals in medical marijuana.</li> <li class="seamTextUnorderedListItem">Syndros is approved to treat patients receiving chemotherapy whose nausea and vomiting are not controlled by other anti-nausea therapies.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03661892' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.practicalpainmanagement.com/resources/news-and-research/fda-approves-syndros-first-liquid-form-cannabinoid-dronabinol' target='_blank'>Practical Pain Management: FDA Approves Syndros, First Liquid Form of Cannabinoid Dronabinol</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/ManagingPainRelatedToMetastaticBreastCancer.html' target='_blank'>Practical Pain Management: FDA Approves Syndros, First Liquid Form of Cannabinoid Dronabinol</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/articles/fda-approves-liquid-formulation-of-thccontaining-drug-for-cinv' target='_blank'>CureToday: FDA Approves Liquid Formulation of THC-Containing Drug for CINV</a> </li></ul>
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207

NEAREST SITE: 752 miles
University of Arizona Cancer Center
Tucson,AZ

VISITS: Weekly for 1 month, then 1 visit every 2 weeks, ongoing

PHASE: I

NCT ID: NCT02627274

RO6874281 Alone or With Trastuzumab For Advanced Breast Cancer

An Open-Label,Multicenter,Dose-Escalation,Phase Ia/Ib Study to Evaluate Safety,Pharmacokinetics, and Therapeutic Activity of RO6874281, an Immunocytokine Consisting of Interleukin 2 Variant (IL-2v) Targeting Fibroblast Activation Protein-α (FAP),as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C) Scientific Title

Purpose
To test the safety and effects (good and bad) of RO6874281 when it is given alone or with trastuzumab (Herceptin®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer. This study will test the safety and effects (good and bad) of RO6874281 when it is given alone or with trastuzumab (Herceptin®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RO6874281, by IV, once every week for 1 month, then once every 2 weeks </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RO6874281, by IV, once every week for 1 month, then once every 2 weeks </li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Herceptin is a HER2-targeted therapy used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">RO6874281 is an investigational targeted therapy that blocks FAP and IL2a. It stimulates immune cells to go after tumor cells. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02627274' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-fap-interleukin-2-fusion-protein-ro6874281' target='_blank'>NCI Drug Dictionary: Anti-FAP/interleukin-2 fusion protein RO6874281</a> </li></ul>
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208

NEAREST SITE: 752 miles
University of Arizona Cancer Center
Tucson,AZ

VISITS: Number of visits unavailable, over 3 weeks

PHASE: NA

NCT ID: NCT03911453

PARP Inhibitor Rucaparib Before Surgery in Patients with Triple Negative Breast Cancer

Window of Opportunity Trial to Evaluate Change in PD-L1 Expression in Triple Negative Breast Tumors in Response to the PARP Inhibitor Rucaparib Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of the PARP inhibitor rucaparib (Rubraca®) when it is given before surgery.
Who is this for?
People with stage I, stage II or stage III triple negative (ER-, PR- and HER2-) breast cancer who are scheduled to have breast cancer surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rucaparib (Rubraca®), by mouth, twice daily, for 3 weeks before surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Possible biopsy before treatment</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rubraca is a targeted therapy that has been approved to treat ovarian cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Giving the drug before surgery allows researchers to study the effect that it has on cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03911453' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2019/02/04/mbc-news-8/' target='_blank'>MetastaticTrialTalk.org: Get the Latest News on PARP Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20090531' target='_blank'>Breastcancer.org: New Type of Targeted Therapy May Help TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/rucaparib.aspx' target='_blank'>Chemocare: Rucaparib</a> </li></ul>
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209

NEAREST SITE: 752 miles
Site 0102
Tucson,AZ

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT04158336

Targeted Therapy ZN-c3 Alone or with Talazoparib or Pembrolizumab in Advanced Breast Cancer

A Phase 1/2 Study of ZN-c3 as a Single Agent and in Combination With Talazoparib or Pembrolizumab in Patients With Solid Tumors Scientific Title

Purpose
To look at the safety and effects (good and bad) of the experimental targeted therapy ZN-c3 when it is used alone or with talazoparib (Talzenna®) or pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups; </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c3, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c3, by mouth</li> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c3, by mouth</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ZN-c3 is tyrosine kinase inhibitor that blocks a protein called WEE1 that helps tumors grow. </li> <li class="seamTextUnorderedListItem">Talzenna® is a type of targeted therapy called a PARP inhibitor. It prevents the PARP protein from repairing damaged DNA in tumor cells. It is approved to treat advanced HER2-negative breast cancer in people with an inherited BRCA mutation. </li> <li class="seamTextUnorderedListItem">Keytruda® is an immunotherapy that targets the programmed cell death (PD-1) protein. Blocking this protein allows the body's immune system to attack cancer cells. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: WEE1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04158336' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/parp-inhibitor' target='_blank'>NCI Drug Dictionary: PARP Inhibitor</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.talzenna.com/?source=google&HBX_PK=s_talazoparib&skwid=43700039109817433' target='_blank'>Pfizer Oncology: Talzenna® (Talazoparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://blog.dana-farber.org/insight/2019/05/the-science-of-pd-1-and-immunotherapy/' target='_blank'>Dana-Farber Cancer Institute: What is PD-1 and Immunotherapy?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.businesswire.com/news/home/20191218005179/en/Zentalis-Pharmaceuticals-Announces-FDA-Clearance-IND-Oncology' target='_blank'>Drug Company Press Release: ZN-c3</a> </li></ul>
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210

NEAREST SITE: 757 miles
Providence St. Patrick Hospital/Community Medical Center
Missoula,MT

VISITS: One visit every year

PHASE: NA

NCT ID: NCT02012699

iCaRe2: Integrated Cancer Data Repository for Cancer Research

Integrated Cancer Repository for Cancer Research Scientific Title

Purpose
To study cancer risk factors, cancer prevention, early detection and personalized cancer treatments by creating a data registry and biobank.
Who is this for?
People who have or are at risk for developing breast cancer and other cancers.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> This is a data collection (registry) study. You will: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Provide biospecimens (blood, urine, tissue) for the biobank</li> <li class="seamTextUnorderedListItem">Complete questionnaires, once a year</li> <li class="seamTextUnorderedListItem">Participate in follow-up visits with your healthcare provider, once a year</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Research sites will implement and maintain a comprehensive data and biospecimen bank known as the Integrated Cancer Repository for Cancer Research (iCaRe2). </li> <li class="seamTextUnorderedListItem">Participants will provide blood, urine and tissue samples for the biobank. </li> <li class="seamTextUnorderedListItem">The data registry and biospecimen bank is made available for research on cancer and other chronic diseases.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02012699' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://icare2project.org' target='_blank'>iCaRe2 Project</a> </li></ul>
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211

NEAREST SITE: 936 miles
Rocky Mountain Cancer Centers - Boulder
Boulder,CO

VISITS: 5 visits over 5 days

PHASE: III

NCT ID: NCT01185132

Intensity-Modulated Radiation Therapy After Lumpectomy

A Phase III Randomized Study Comparing Intensity Modulated Planning Versus 3-Dimensional Planning for Accelerated Partial Breast Radiotherapy Scientific Title

Purpose
To compare the effectiveness of intensity-modulated radiation therapy with standard accelerated 3D-conformal external beam radiotherapy
Who is this for?
People, 40 or older, with stage I or II breast cancer, and planning to receive a lumpectomy followed by radiation    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intensity-Modulated Radiotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intensity-modulated radiotherapy over 5 days</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: 3D-Conformal External Beam Radiotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3D-conformal external beam radiotherapy over 5 days</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Women whose breast cancer treatment includes a lumpectomy almost always receive radiation as well. </li> <li class="seamTextUnorderedListItem">Intensity-modulated radiation therapy is a type of high-precision radiotherapy that can more precisely deliver radiation to the three-dimensional (3-D) shape of the tumor. </li> <li class="seamTextUnorderedListItem">This allows higher radiation doses to be focused on the site of the tumor while minimizing the amount of radiation the surrounding normal breast and lung tissue receive.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01185132' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.radiologyinfo.org/en/info.cfm?pg=imrt' target='_blank'>RadiologyInfo.org: IMRT</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancercenter.com/treatments/intensity-modulated-radiation-therapy/' target='_blank'>CamcerCemter.com: IMRT Video</a> </li><li class='seamTextUnorderedListItem'><a href='https://rockymountaincancercenters.com/innovative-treatments/radiation-therapy-services#IMRT' target='_blank'>Rocky Mountain Cancer Center: IMRT</a> </li></ul>
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212

NEAREST SITE: 941 miles
University of Colorado Cancer Center
Aurora,CO

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT02719691

MLN0128 and Alisertib for Metastatic Triple-Negative Breast (and Other Advanced) Cancers

A Phase Ib Study of the Combination of MLN0128 (Dual TORC1/2 Inhibitor) and MLN8237 (Aurora A Inhibitor, Alisertib) in Patients With Advanced Solid Tumors With an Expansion Cohort in Metastatic Triple-negative Breast Cancer (TNBC) Scientific Title

Purpose
To determine if the combination of Alisertib and MLN0128, an mTOR inhibitor, is safe and effective.
Who is this for?
People with metastatic (stage IV) triple negative breast cancer. You must have received one prior round of chemotherapy, either following surgery for early breast cancer or for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alisertib (MLN8237), by mouth, twice daily, for 1 week every month</li> <li class="seamTextUnorderedListItem">MLN0128, by mouth daily, for 2-3 weeks every month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MLN0128 is a new type of targeted therapy called an mTOR inhibitor.</li> <li class="seamTextUnorderedListItem">Alisertib (MLN8237) is a new targeted therapy that blocks an enzyme--Aurora A kinase--that helps cancer cells grow.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02719691' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/study/NCT02719691#contacts' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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213

NEAREST SITE: 941 miles
University of Colorado Denver
Aurora,CO

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT01503190

Immune System Response to Breast Cancer in Women Under Age 50

A Translational Study of the Interactions Between Prior Pregnancy and the Biologic Subtype of Breast Cancer in Defining the Cancer: Host Immunologic Interaction Scientific Title

Purpose
To determine how the immune system responds to different types of tumors or to tumors that develop during or after a pregnancy. Some of the breast cancer tissue collected in this study will be used to create models that develop and test new drug treatments.
Who is this for?
Women with any stage of breast cancer who are 50 years or younger    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will provide the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tissue, blood and urine samples, if recently diagnosed</li> <li class="seamTextUnorderedListItem">Tissue donation only, if enrolled after treatment has begun or has ended</li></ul>
  • <p class="seamTextPara"> Researchers are interested in learning more about the role the immune system plays in cancer. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is looking specifically at the level of immune suppression seen in breast cancer that occurs in women under age 50.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01503190' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/tips/immune/' target='_blank'>BreastCancer.org: Understanding Your Immune System</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.youngsurvival.org/' target='_blank'>Young Survival Coalition</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/MedicalOncology/faculty/Pages/VirginiaFBorges,MD.aspx' target='_blank'>Study PI: Virginia F. Borges, MD</a> </li></ul>
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214

NEAREST SITE: 941 miles
University of Colorado
Aurora,CO

VISITS: Weekly visits for 3 weeks, then once a month for 3 months

PHASE: II

NCT ID: NCT02955394

Fulvestrant plus Enzalutamide Before Surgery in AR+, ER+, HER2- Breast Cancer

Randomized Phase II Trial of Preoperative Fulvestrant With or Without Enzalutamide in ER+/Her2- Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of giving an anti-estrogen drug along with an anti-androgen drug before surgery.
Who is this for?
Women with stage II and stage III estrogen receptor positive (ER+), HER2 negative breast cancer. Your tumor must also be androgen receptor positive (AR+)    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, once a week for 3 weeks then once a month for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, once a week for 3 weeks then once a month for 3 months</li> <li class="seamTextUnorderedListItem">Enzalutamide (Xtandi®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">If you are pre- or peri- menopausal, you will also be given a therapy that will stop your ovaries from producing estrogen</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is the anti-estrogen drug being used in this study. It is approved to treat postmenopausal women with metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">The anti-androgen drug used in this study is enzalutamide (Xtandi®). It is currently used to treat prostate cancer.</li> <li class="seamTextUnorderedListItem">If you are pre- or perimenopausal, you will also be given a therapy that will stop your ovaries from producing estrogen.</li> <li class="seamTextUnorderedListItem">Targets or mutations: AR (androgen receptor)</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02955394' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/issues/june-10-2017/targeting-the-androgen-receptor-in-breast-cancer/' target='_blank'>ASCO: Treating AR in Breast Cancer</a> </li></ul>
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215

NEAREST SITE: 941 miles
University of Colorado
Aurora,CO

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03332797

GDC-9545 plus Ibrance for Locally Advanced or Metastatic ER+ Breast Cancer

A Phase Ia/Ib, Multicenter, Open-Label, Dose Escalation, Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-9545 Alone or in Combination With Palbociclib and/or LHRH Agonist in Patients With Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of giving GDC-9545 alone or with Ibrance to treat advanced breast cancer.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) breast cancer that is estrogen receptor positive and HER2 negative. You must not have received more than 2 prior anti-cancer therapies for advanced or metastatic breast cancer    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive one, two or three of the following drugs: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-9545, by mouth, daily</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Luteinizing hormone-releasing hormone (LHRH) agonist, by injection, monthly</li></ul>
  • <p class="seamTextPara"> GDC-9545 is the experimental drug being used in this study. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a type of targeted therapy that keeps cancer cells from growing by blocking two proteins, CDK 4 and CDK 6. It is approved by the FDA to treat postmenopausal women with ER+, HER2- metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Luteinizing hormone-releasing hormone (LHRH) agonist keeps the ovaries from making estrogen and progesterone.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03332797' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/targeted_therapies' target='_blank'>Breastcancer.org: Targeted Therapy</a> </li></ul>
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216

NEAREST SITE: 941 miles
University of Colorado Denver- Anschutz Medical Center
Aurora,CO

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03601897

Rebastinib and Paclitaxel in People with Metastatic Breast Cancer

An Open-Label, Multicenter, Phase 1b/2 Study of Rebastinib (DCC-2036) in Combination With Paclitaxel to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using the experimental drug rebastinib along with paclitaxel (Taxol®)
Who is this for?
People with metastatic breast cancer. You must have received prior treatment for metastatic breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rebastinib (DCC-2036), by mouth</li> <li class="seamTextUnorderedListItem">Paclitaxel, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rebastinib is an investigational targeted therapy. </li> <li class="seamTextUnorderedListItem">Taxol is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">This study is also enrolling women with ovarian cancer and endometrial cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03601897' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.deciphera.com/pipeline/rebastinib/' target='_blank'>Sponsor Site & Drug Company Information Page: Rebastinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/druglist/taxol' target='_blank'>Breastcancer.org: Taxol</a> </li><li class='seamTextUnorderedListItem'><a href='https://malebreastcancercoalition.org' target='_blank'>Male Breast Cancer Coalition</a> </li></ul>
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217

NEAREST SITE: 941 miles
University of Colorado Denver
Aurora,CO

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03739931

mRNA-2752 & Durvalumab for Advanced Triple Negative Breast Cancer

A Phase 1, Open-Label, Multicenter, Dose Escalation Study of mRNA-2752, a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L, IL-23, and IL-36γ, for Intratumoral Injection Alone and in Combination With Immune Checkpoint Blockade Scientific Title

Purpose
To study the safety, best dose and effects (good and bad) of mRNA-2752 when it is combined with durvalumab (Imfinzi®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that has already been treated with adequate standard of care therapies.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem"> mRNA-2752, by injection</li> <li class="seamTextUnorderedListItem">IMFINZI® (durvalumab), by IV</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">mRNA-2752 is injected directly into a tumor. It is designed to make a tumor more responsive to an immunotherapy drug. </li> <li class="seamTextUnorderedListItem">Imfinzi® is a type of immunotherapy called a PD-L1 (programmed cell death ligand-1) inhibitor. It works by stimulating the body's immune system to go after cancer cells. It has been approved to treat certain types of cancers. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03739931' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.imfinzi.com/stage-3-nsclc/about/how-imfinzi-works.html?source=imz_c_c_45&umedium=cpc&uadpub=google&ucampaign=2018imfinzidtcnsclcbranded_general&ucreative=branded_alone_ph&uplace=durvalumab&outcome=dtc&cmpid=1' target='_blank'>AstraZeneca Drug Information Page: Imfinzi®</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/796816' target='_blank'>NCI Drug Dictionary: mRNA-2752</a> </li><li class='seamTextUnorderedListItem'><a href='https://cancerres.aacrjournals.org/content/79/13_Supplement/CT210' target='_blank'>AACR Abstract: mRNA-2752</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.modernatx.com/pipeline/therapeutic-areas/immuno-oncology' target='_blank'>Drug Company Information Page: Intratumoral Immuno-Oncology Therapeutics</a> </li><li class='seamTextUnorderedListItem'><a href='https://stm.sciencemag.org/content/11/477/eaat9143.full?ijkey=nRihB/hFvaoUw&keytype=ref&siteid=scitransmed' target='_blank'>Journal Article: Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs</a> </li></ul>
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218

NEAREST SITE: 941 miles
University of Colorado
Aurora,CO

VISITS: Number of visits unavailable, over 2 weeks

PHASE: I

NCT ID: NCT03916744

GDC-9545 in Postmenopausal Women With Stage I, II or III ER-Positive Breast Cancer

A Phase I, Multicenter, Open-Label Preoperative, Short-Term Window Study of GDC-9545 in Postmenopausal Women With Stage I-III Operable, Estrogen Receptor-Positive Breast Cancer Scientific Title

Purpose
To evaluate the safety, effects (good and bad) and best dose of GDC-9545, an investigational hormone therapy.
Who is this for?
Postmenopausal women with estrogen receptor (ER) positive, HER2 negative stage I, stage II or stage III breast cancer who have not yet started cancer treatment.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following treatment before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-9545, by mouth, once daily, for 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-9545 is an investigational hormone therapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03916744' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/792379' target='_blank'>NCI Drug Dictionary: SERD GDC-9545</a> </li><li class='seamTextUnorderedListItem'><a href='https://cancerres.aacrjournals.org/content/79/4_Supplement/P5-04-07' target='_blank'>Cancer Research: GDC-9545</a> </li></ul>
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219

NEAREST SITE: 947 miles
HealthONE Clinic Services Oncology-Hematology
Denver,CO

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04045496

A New Targeted Therapy (JAB-3312) for Advanced Breast and Other Cancers

A Phase 1, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of JAB-3312 in Adult Patients With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, best dose, and effects (good and bad) of the experimental drug JAB-3312.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that was treated with standard therapies or who have no standard therapy options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">JAB-3312, by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">JAB-3312 is a type of targeted therapy called a KRAS inhibitor. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04045496' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/799443' target='_blank'>NCI Drug Dictionary: JAB-3312</a> </li><li class='seamTextUnorderedListItem'><a href='http://en.jacobiopharma.com/news/97.html' target='_blank'>Drug Company Information Page: JAB-3312</a> </li></ul>
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220

NEAREST SITE: 948 miles
Sarah Cannon Research Institute at HealthOne
Denver,CO

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04148937

The Targeted Therapy LY3475070 Alone or With Pembrolizumab in Advanced Breast Cancer

A Phase 1 Multicenter Global First in Human Study of the CD73 Inhibitor LY3475070 as Monotherapy or in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies Scientific Title

Purpose
To study the safety, anti-cancer activity, and effects (good and bad) of the experimental targeted therapy LY3475070 when it is given alone or with the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) breast cancer who have no other standard treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3475070, by mouth, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3475070, by mouth, ongoing</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3475070 is a type of investigational therapy called a CD73 inhibitor. </li> <li class="seamTextUnorderedListItem">CD73 is a protein that may be a new biomarker in triple negative (ER-, PR-, HER2-) breast cancer. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking PD-1.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is approved to treat certain other types of cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04148937' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lillytrialguide.com/en-US/studies/advanced-cancer/jzma' target='_blank'>Eli Lilly & Company Trial Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=pembrolizumab&utm_kxconfid=sq7irm3mh&gclid=CjwKCAiA1L_xBRA2EiwAgcLKA1rjY2sDvGijJBKlq4pryVynCh4LO-tR1STTRbK7a6-qFcn3XQre2RoC' target='_blank'>Merck Oncology: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='http://tcr.amegroups.com/article/view/21463/html' target='_blank'>Journal Article: CD73, A New Biomarker in Triple-negative Breast Cancer</a> </li></ul>
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221

NEAREST SITE: 996 miles
Texas Tech University HSC El Paso
El Paso,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03144037

Adherence to Aromatase Inhibitors in Stage I-III, HR+ Latina & Other Breast Cancer Patients

Adherence of Hispanic / Latina Breast Cancer - Patients to Adjuvant Aromatase Inhibitors - (AIs) Scientific Title

Purpose
To learn more about how well women on AI hormone therapy follow their treatment plan.
Who is this for?
Postmenopausal women with stage I, stage II, or stage III, hormone receptor positive (ER+ and/or PR+) breast cancer taking an aromatase inhibitor (AI) after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will complete a medication adherence survey in English or Spanish.</p>
  • <p class="seamTextPara"> The researchers are making an effort to recruit Latinas being treated at Texas Tech University Health Sciences Center in El Paso, but women of any ethnicity can enroll.</p>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03144037' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.peervoice.com/tool-may-help-predict-adherence-aromatase-inhibitor-therapy-breast-cancer-presented-sabcs' target='_blank'>Tool May Help Predict Adherence to AI</a> </li></ul>
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222

NEAREST SITE: 1175 miles
St. Catherine Hospital - Central Care Cancer Center
Garden City,KS

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02595320

Comparing Two Different Doses of Xeloda for Metastatic Breast (and GI) Cancer

Randomized Open-label Trial of Dose Dense, Fixed Dose Capecitabine Compared to Standard Dose Capecitabine in Metastatic Breast Cancer and Advanced/Metastatic Gastrointestinal Cancers Scientific Title

Purpose
To compare the effectiveness and side effects associated with two different doses and dosing schedules of Xeloda in women with metastatic breast cancer.
Who is this for?
Women with metastatic (stage IV) breast cancer who have not received Xeloda (capecitabine) for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: 1500 mg</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capacitabine (Xeloda®), by mouth, twice daily, 1 week on, 1 week off</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: 1250 mg</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capacitabine (Xeloda®), by mouth, twice daily, 2 weeks on, 1 week off</li></ul>
  • <p class="seamTextPara"> Capecitabine (Xeloda®) is a chemotherapy drug used to treat metastatic breast cancer that has stopped responding to other chemotherapy drugs. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Xeloda® is an oral drug and can be taken at home.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02595320' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02595320?term=NCT02595320&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancerresearchuk.org/about-cancer/cancers-in-general/treatment/cancer-drugs/capecitabine' target='_blank'>Capecitabine (Xeloda®)</a> </li><li class='seamTextUnorderedListItem'><a href='http://mbcn.org/' target='_blank'>Metastatic Breast cancer Network</a> </li></ul>
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223

NEAREST SITE: 1251 miles
Hays Medical Center Dreiling-Schmidt Cancer Institute
Hays,KS

VISITS: 1 visit

PHASE: NA

NCT ID: NCT02302742

A Registry for People with Triple Negative Breast Cancer or an Inherited BRCA1/2 or Certain Other Mutations

PROspective Evaluation of GErmline Mutations, Cancer Outcome and Tissue Biomarkers: A Registry for Patients With Triple Negative Breast Cancer and Germline Mutations (PROGECT) Scientific Title

Purpose
To learn more about the relationship between genetic mutations and cancer outcomes.
Who is this for?
People with inherited BRCA1/2 mutations or certain other genetic mutations (see list below) and people with stage I, stage II, stage III, or stage IV triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> This is a data collection (registry) study. You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 blood test</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Studies have found a relationship between triple negative breast cancer and inherited BRCA 1 and BRCA 2 mutations. </li> <li class="seamTextUnorderedListItem">Targets or mutations: BRCA1, BRCA2, PTEN, P53, and PALB2</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02302742' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer' target='_blank'>ASCO: Hereditary Breast and Ovarian Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://ww5.komen.org/BreastCancer/InheritedGeneticMutations.html' target='_blank'>Susan G. Komen: Inherited Gene Expressions</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://ghr.nlm.nih.gov/condition/breast-cancer' target='_blank'>NIH Genetics Home Reference: Breast Cancer</a> </li></ul>
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224

NEAREST SITE: 1298 miles
CHI Health Saint Francis
Grand Island,NE

VISITS: 6 visits over 3 months, plus surgery

PHASE: II

NCT ID: NCT01750073

Chemotherapy & Herceptin Before Surgery for Stage I-III Tumors

A Phase II Study of Neoadjuvant Chemotherapy With and Without Trastuzumab in Patients With Breast Cancer Scientific Title

Purpose
To study the effects (good and bad) that occur when giving Taxol and Cytoxan.
Who is this for?
Women with stage I, stage II, or stage III breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following treatment: </p> <p class="seamTextPara"> <u>Before surgery:</u> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) and Cyclophosphamide (Cytoxan®) by IV every 2 weeks, for 12 weeks </li> </ul> <p class="seamTextPara"> Participants with HER2 positive tumors will also receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) by IV every 2 weeks, for 12 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Mastectomy or breast conserving surgery follows 4-8 weeks later.</i> </p> <p class="seamTextPara"> <u>Post-Surgery:</u> </p> <p class="seamTextPara"> HER2 POSITIVE PATIENTS: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard radiation therapy</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) by IV every 3 week for up to 13 courses</li> </ul> <p class="seamTextPara"> ER/PR POSITIVE PATIENTS: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard hormonal or endocrine therapy</li> </ul> <p class="seamTextPara"> STAGE I TRIPLE NEGATIVE PATIENTS: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard radiation therapy</li> </ul> <p class="seamTextPara"> STAGE II-III TRIPLE NEGATIVE PATIENTS: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doxorubicin hydrochloride (Adriamycin®) by IV every 2 weeks for up to 4 courses</li> <li class="seamTextUnorderedListItem">Standard radiation therapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving chemotherapy before surgery may make the tumor smaller, reducing the amount of tissue that needs to be removed during surgery. </li> <li class="seamTextUnorderedListItem">It also allows researchers to study how tumors respond to certain drugs. Paclitaxel (Taxol®) and cyclophosphamide (Cytoxan®) are two chemotherapy drugs that are routinely used to treat breast cancer. Trastuzumab (Herceptin®) is a targeted therapy that is used to treat HER2-positive breast cancer. </li> <li class="seamTextUnorderedListItem">Patients with HER2+ tumors will also receive Herceptin prior to surgery, so that the researchers can study a three drug combination®Taxol, Cytoxan, and Herceptin.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01750073' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/factsheet/Therapy/adjuvant-breast' target='_blank'>Cancer.gov: Adjuvant and Neoadjuvant Therapy for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-treating-by-stage' target='_blank'>ACS: Breast Cancer Treatment</a> </li></ul>
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225

NEAREST SITE: 1387 miles
Research Site
Oklahoma City,OK

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03205176

AZD5153 Alone or With Olaparib in Advanced Triple Negative Breast Cancer

A Phase I, Multicenter Dose-Escalation Study to Assess the Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of AZD5153 in Patients With Relapsed/Refractory Malignant Solid Tumors, Including Lymphomas Scientific Title

Purpose
To study the safety and effects (good and bad) of giving the targeted therapy AZD5153 alone and in combination with the PARP inhibitor olaparib (Lynparza®).
Who is this for?
People with advanced (stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD5153, by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD5153, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice a day, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD5153 is an investigational targeted therapy (only available in clinical trials). </li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of targeted therapy called a PARP inhibitor. It stops the growth of cancer cells by blocking enzymes called poly ADP ribose polymerase (PARP).</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is approved to treat metastatic, HER2 negative breast cancer in women with a hereditary BRCA 1 or BRCA 2 mutation. Its use in this trial is considered experimental. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03205176' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://openinnovation.astrazeneca.com/azd5153.html' target='_blank'>AstraZeneca Drug Information Page: AZD5153</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793144' target='_blank'>NCI Drug Dictionary: AZD5153</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparzahcp.com/ovarian-cancer/home.html?source=lyn_d_h_15&umedium=cpc&uadpub=google&ucampaign=lynparzahcpovarian_branded_alone_2019&ucreative=generic_alone_ex&uplace=olaparib&outcome=hcp&cmpid=1&gclid=CjwKCAjwpqv0BRABEiwA-TySwSHK0dvXHqFh8iMkn' target='_blank'>AstraZeneca Drug Information Page: Lynparza® (Olaparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/lynparza' target='_blank'>Breastcancer.org: Lynparza® (Olaparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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226

NEAREST SITE: 1387 miles
University of Oklahoma
Oklahoma City,OK

VISITS: 2 visits per week, ongoing

PHASE: I

NCT ID: NCT03364400

VT1021 in Metastatic Triple Negative Breast Cancer

A Phase 1 Study Evaluating the Safety, Pharmacology, and Preliminary Activity of VT1021 in Patients With Advanced Solid Tumors Scientific Title

Purpose
To study the effects (good and bad) of the experimental drug VT1021.
Who is this for?
People with metastatic (stage IV), triple negative (ER-, PR-, HER2-) breast cancer who have already received at least three lines of therapy in the metastatic setting.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">VT1021, by IV, twice a week, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">VT1021 is an experimental targeted therapy that researchers believe may work by affecting the tumor's microenvironment (the tissue surrounding the tumor).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03364400' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://vigeotherapeutics.com' target='_blank'>Drug Company Information Page: VT1021</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2020/03/03/mbc-news-20/' target='_blank'>Metastatic Trial Talk: The Tumor Microenvironment</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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227

NEAREST SITE: 1387 miles
Stephenson Cancer Center
Oklahoma City,OK

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03775850

Immunotherapy EDP1503 With Pembrolizumab For Advanced Triple Negative Breast Cancer

A Phase I/II Open-label Study of EDP1503 Alone and in Combination With Pembrolizumab in Patients With Advanced Metastatic Colorectal Carcinoma, Triple-negative Breast Cancer, and Checkpoint Inhibitor Relapsed Tumors Scientific Title

Purpose
To assess the safety and the effects (good and bad) of the immunotherapy EDP1503 when it is given along with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV),triple negative (ER-, PR-, HER2-) breast cancer who have no other approved treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EDP1503, by mouth, twice daily, for 2 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EDP1503, by mouth, twice daily </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EDP1503 is an experimental immunotherapy that may work by changing the microenvironment that surrounds the cancer cells. </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">It is only approved to treat certain types of breast cancers. Its use in this trial is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03775850' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/795263' target='_blank'>NCI: Monoclonal microbial EDP1503</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pharmacychoice.com/News/article.cfm?Article_ID=2142547' target='_blank'>Pharmacy Choice: Evelo Enters into Clinical Trial Collaboration Agreement with Merck</a> </li><li class='seamTextUnorderedListItem'><a href='https://globenewswire.com/news-release/2019/01/04/1680530/0/en/Evelo-Biosciences-Announces-Dosing-of-First-Patient-in-Phase-1-2-Clinical-Trial-of-EDP1503-in-Combination-with-KEYTRUDA-pembrolizumab-in-Multiple-Oncology-Indications.html' target='_blank'>Evelo Press Release: EDP1503</a> </li></ul>
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228

NEAREST SITE: 1387 miles
Stephenson Cancer Center
Oklahoma City,OK

VISITS: 1 to 4 visits monthly, ongoing

PHASE: I

NCT ID: NCT03829436

TPST-1120 Alone or With a Systemic Therapy in Advanced Triple Negative Breast Cancer

A Phase 1/1b Open-label, Dose-escalation and Dose-expansion Study of TPST-1120 as a Single Agent or in Combination With Systemic Anti-Cancer Therapies in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, best dose and effects (good and bad) of TPST-1120 when it is used alone or with another anti-cancer drug.
Who is this for?
People with triple negative advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1120, by mouth, twice daily </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1120, by mouth, twice daily </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, once a month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1120, by mouth, twice daily </li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV, once every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1120, by mouth, twice daily </li> <li class="seamTextUnorderedListItem">Cetuximab (Erbitux®), by IV, once a week</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1120 is an investigational drug that targets a protein called PPARα. </li> <li class="seamTextUnorderedListItem">The other drugs it may be given with are nivolumab (Opdivo®), docetaxel (Taxotere®), and cetuximab (Erbitux®). </li> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy called a PD-1 inhibitor. It has been approved to treat certain types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Taxotere is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Erbitux is a targeted therapy that blocks EGFR. It is approved to treat head, neck and colorectal cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This trial also is enrolling patients with other types of advanced cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03829436' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medpagetoday.com/reading-room/asco/breast-cancer/79947' target='_blank'>Medpage Today: Cetuximab in Metastatic Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.esmo.org/Oncology-News/Promising-Response-Rates-in-Patients-with-Metastatic-TNBC-Treated-with-Nivolumab-After-Induction-Treatment' target='_blank'>ESMO 2017: Promising Response Rates in Patients with Metastatic TNBC Treated with Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/docetaxel-taxotere' target='_blank'>Cancer Research UK: Docetaxel</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/79/13_Supplement/3606' target='_blank'>Cancer Research: TPST-1120 suppresses tumor growth and stimulates anti-tumor immunity</a> </li></ul>
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229

NEAREST SITE: 1387 miles
Stephenson Cancer Center (Oklahoma University)
Oklahoma City,OK

VISITS: 1 visit a week, ongoing

PHASE: I-II

NCT ID: NCT04180371

BT5528 Alone or With Nivolumab in Advanced Triple Negative Breast Cancer That Tests EphA2+

Phase I/II Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT5528 in Patients With Advanced Malignancies Associated With EphA2 Expression Scientific Title

Purpose
To study the safety, effects (good and bad), and best dose of an experimental therapy called BT5528 when it is given alone or with nivolumab (Opdivo®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR-, HER2-), have already tried other cancer treatments, have no other standard treatment options, and have a tumor that tests positive for a protein called EphA2.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> This trial is being conducted in two parts. You will participate in 1 of 2 parts depending on when you enroll: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BT5528, by IV, once a week, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BT5528, by IV, once a week, ongoing</li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, once every 4 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BT5528 targets a protein called EphA2 that helps cancer cells grow. </li> <li class="seamTextUnorderedListItem">EphA2 is found on some triple negative breast tumors. </li> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04180371' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.bicycletherapeutics.com/programs/' target='_blank'>Bicycle Therapeutics Information Page: BT5528</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nature.com/articles/onc2017170' target='_blank'>Journal Article: Targeting EphA2 In Triple Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.opdivo.com/about-opdivo/how-opdivo-works-monotherapy' target='_blank'>Bristol-Meyers Squibb Information Page: Opdivo</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/publications/cure/2019/immunotherapy-2019/breast-cancer-gets-a-boost-from-immunotherapy' target='_blank'>Cure Today: Breast Cancer Gets a Boost From Immunotherapy</a> </li></ul>
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230

NEAREST SITE: 1387 miles
Stephenson Cancer Center
Oklahoma City,OK

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04247126

Targeted Therapy SY 5609 in Advanced, Hormone Positive, HER2 Negative Breast Cancer

A Phase 1 Study of SY 5609, an Oral, Selective CDK7 Inhibitor, in Adult Patients With Select Advanced Solid Tumors Scientific Title

Purpose
To study the best dose, safety, and anti-cancer activity of the experimental targeted therapy SY 5609.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV), hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer whose disease progressed while receiving a CDK 4/6 inhibitor and an anti-hormone therapy. If you are a woman, you must also be postmenopausal.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SY-5609, by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SY 5609 is an experimental type of targeted therapy called a CDK 7 inhibitor (cyclin-dependent kinase 7 inhibitor).</li> <li class="seamTextUnorderedListItem">Researchers believe that SY 5609 may be effective in treating tumors that have not responded to a CDK 4/6 inhibitor.</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a hormone therapy approved to treat postmenopausal women with advanced breast cancer.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04247126' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.syros.com/programs/sy-5609' target='_blank'>Syros Pharmaceuticals Drug Information Page: SY 5609</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/fulvestrant.aspx' target='_blank'>Chemocare: Fulvestrant (Faslodex®)</a> </li></ul>
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231

NEAREST SITE: 1387 miles
Bolt Investigative Site
Oklahoma City,OK

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT04278144

BDC-1001 With or Without Keytruda for People With Advanced HER2 Positive Breast Cancer

Phase 1 Study of BDC-1001 as a Single Agent and in Combination With Pembrolizumab in Patients With Advanced and HER2-Expressing Solid Tumors Scientific Title

Purpose
To study the anti-cancer activity and effects (good and bad) of giving the new immunotherapy drug BDC-1001 alone and with the PD-1 inhibitor pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+) breast cancer who have no other treatment options available.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> This is a 2-part study. Depending upon which part of the trial is open when you enroll, you will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BDC-1001</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BDC-1001</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BDC-1001 is an investigational drug called an Immune Stimulating Antibody Conjugate. It combines an anti-HER2 drug with a drug that targets the TLR7/8 proteins. </li> <li class="seamTextUnorderedListItem">Researchers think targeting the TLR7/8 proteins can help make tumors more likely to respond to pembrolizumab (Keytruda®). </li> <li class="seamTextUnorderedListItem">Pembrolizumab is another type of immunotherapy called a PD-1 inhibitor. It works by getting the immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04278144' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://boltbio.com/#ourscience' target='_blank'>Drug Company Information Page: BDC-1001</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytru' target='_blank'>Merck Oncology: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nationalbreastcancer.org/breast-cancer-targeted-therapy' target='_blank'>National Breast Cancer Foundation: Targeted Therapy (Monoclonal Antibodies)</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Immune_stimulating_antibody_conjugate' target='_blank'>Wikipedia: Immune Stimulating Antibody Conjugate</a> </li></ul>
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232

NEAREST SITE: 1398 miles
Avera Cancer Institute
Sioux Falls,SD

VISITS: Coincides with surgery

PHASE: II

NCT ID: NCT02927912

Radiation Therapy During Surgery for Patients with Stage I-II Breast Cancer

Multi-institution Phase II Trial of Intraoperative Electron Beam Radiotherapy Boost at the Time of Breast Conserving Surgery With Oncoplastic Reconstruction in Women With Early-Stage Breast Cancer Scientific Title

Purpose
To study the effects (good and bad) of delivering radiation therapy during surgery.
Who is this for?
Women with stage I or stage II breast cancer and who are planning to have breast conserving surgery (lumpectomy) with reconstruction.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> You will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative electron radiotherapy (IOERT) delivered directly after lumpectomy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by standard of care reconstruction and whole breast radiation therapy</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative Electron Therapy (IOERT) is a radiation treatment used during surgery. It delivers a concentrated beam of radiation directly to the area where the tumor was removed.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02927912' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation/types/intraoperative' target='_blank'>Breastcancer.org: Intraoperative Radiation</a> </li></ul>
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233

NEAREST SITE: 1398 miles
Avera Cancer Institute
Sioux Falls,SD

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03154281

PARP Inhibitor Niraparib With Everolimus in Advanced HER2 Negative Breast Cancer

A Phase 1 Evaluation of the Safety and Tolerability of Niraparib in Combination With Everolimus in Advanced Ovarian and Breast Cancer Scientific Title

Purpose
To assess the safety, effects (good and bad) and best dose of the PARP inhibitor niraparib (Zejula®) when used with everolimus (Afinitor®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer who have no standard treatment options available and who have not already received a PARP inhibitor.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Niraparib (Zejula®), by mouth, daily </li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth, daily or every other day</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Zejula is at type of targeted therapy called a PARP inhibitor. These drugs block poly (ADP-ribose) polymerase. </li> <li class="seamTextUnorderedListItem">This enzyme helps cancer cells grow by repairing their DNA. It is approved to treat women with certain types of reproductive cancers. </li> <li class="seamTextUnorderedListItem">Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Afinitor is a type of targeted drug called an mTOR inhibitor. It is used to treat advanced hormone receptor-positive, HER2-negative breast cancer. </li> <li class="seamTextUnorderedListItem">This study also is recruiting patients with ovarian cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03154281' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fda.gov/drugs/resources-information-approved-drugs/everolimus-afinitor' target='_blank'>FDA Approval: Everolimus (Afinitor®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fda.gov/drugs/resources-information-approved-drugs/niraparib-zejula' target='_blank'>FDA Approval: Niraparib (Zejula®)</a> </li></ul>
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234

NEAREST SITE: 1414 miles
Nebraska Cancer Center Oncology Hematology West P.C.
Omaha,NE

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04306900

TTX-030 in Combination With Chemotherapy or Immunotherapy or Both in Advanced Breast Cancer

Phase 1/1b Study to Evaluate the Safety and Activity of TTX-030 (Anti-CD39) in Combination With Budigalimab and/or Chemotherapy in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of using TTX-030 (an experimental drug that targets the tumor microenvironment) with either chemotherapy or Budigalimab (a type of immunotherapy) or both chemotherapy and Budigalimab.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TTX-030</li> <li class="seamTextUnorderedListItem">Budigalimab (ABBV-181), by IV</li> <li class="seamTextUnorderedListItem">mFOLFOX6, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TTX-030</li> <li class="seamTextUnorderedListItem">Budigalimab (ABBV-181), by IV</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TTX-030</li> <li class="seamTextUnorderedListItem">mFOLFOX6, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TTX-030</li> <li class="seamTextUnorderedListItem">Budigalimab (ABBV-181), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TTX-030 is an experimental drug that may work by changing the tumor microenvironment (the tissue that surrounds the tumor) and by causing the immune system to go after the tumor. </li> <li class="seamTextUnorderedListItem">Budigalimab (ABBV-181) is an experimental PD-1 inhibitor. PD-1 inhibitors are a type of immunotherapy that get the immune system to see and go after cancer cells.</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®) is a chemotherapy commonly used in breast cancer. </li> <li class="seamTextUnorderedListItem">mFOLFOX6 is a chemotherapy regimen that combines three different drugs: leucovorin calcium, fluorouracil, and, oxaliplatin. It is commonly used in colorectal cancer.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04306900' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tizonatx.com/science/' target='_blank'>Drug Company Information Page: TTX-030</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-pd1-monoclonal-antibody-abbv-181' target='_blank'>NCI Drug Dictionary: Budigalimab (ABBV-181)</a> </li><li class='seamTextUnorderedListItem'><a href='https://abbviescience.com/oncology/pipeline' target='_blank'>Drug Company Information Page: ABBV-181 (Budigalimab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/folfox' target='_blank'>NCI Drug Dictionary: mFOLFOX-6</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/docetaxel.aspx' target='_blank'>Chemocare: Docetaxel</a> </li></ul>
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235

NEAREST SITE: 1418 miles
University of Nebraska Medical Center
Omaha,NE

VISITS: 2-3 visits per month, ongoing

PHASE: II

NCT ID: NCT03393845

Keytruda and Faslodex for HR+, HER2- Advanced Breast Cancer

A Phase II Study of Pembrolizumab Plus Fulvestrant in Hormone Receptor Positive, HER-2 Negative Advanced/Metastatic Breast Cancer Patients: Big Ten Cancer Research Consortium BTCRC-BRE16-042 Scientific Title

Purpose
To investigate the safety and effect (good and bad) of using pembrolizumab (Keytruda®) along with fulvestrant (Faslodex®) to treat HR+, HER2- advanced breast cancer.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that is estrogen receptor positive and HER2 negative. You cannot have received more than one prior regimen of hormone therapy or chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, every 2 weeks for 6 weeks, then once a month, ongoing</li></ul>
  • <p class="seamTextPara"> Keytruda® is type of immunotherapy called a PD-1 inhibitor. It is approved to treat certain types of cancers, including breast cancer. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Faslodex® is a hormone therapy that is used to treat hormone sensitive breast cancer in postmenopausal women.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03393845' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ihatebreastcancer.wordpress.com/tag/keytruda/' target='_blank'>IHateBreastCancer: ASCO 2017: METASTATIC BREAST CANCER HIGHLIGHTS</a> </li></ul>
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236

NEAREST SITE: 1478 miles
Mary Crowley Cancer Research Center
Dallas,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT02393248

Targeted Therapy Pemigatinib Alone or with Chemotherapy, Immunotherapy, or Anti-HER2 Targeted Therapy in Advanced Breast Cancer

A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCB054828 in Subjects With Advanced Malignancies (FIGHT-101) Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of the experimental kinase inhibitor Pemigatinib (Pemazyre™) when it is used alone or in combination with chemotherapy, immunotherapy, or an anti-HER2 targeted therapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment available. Your tumor must test positive for or express one of the following: FGF or FGFR.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 6 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pemigatinib (Pemazyre™), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pemigatinib (Pemazyre™), by IV</li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV</li> <li class="seamTextUnorderedListItem">Cisplatin (Platinol®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pemigatinib (Pemazyre™), by IV</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pemigatinib (Pemazyre™), by IV</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 5</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pemigatinib (Pemazyre™), by IV</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 6</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pemigatinib (Pemazyre™), by IV</li> <li class="seamTextUnorderedListItem">INCMGA00012, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pemigatinib (Pemazyre™) is an experimental kinase inhibitor, a type of targeted therapy, that is designed to block the FGFR (fibroblast growth factor receptor) protein. </li> <li class="seamTextUnorderedListItem">Laboratory studies show that targeting FGFR may slow or stop cancer cell growth.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: FGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02393248' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Pemigatinib' target='_blank'>Wikipedia: Pemigatinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fgfr-inhibitor-incb054828' target='_blank'>NCI Drug Dictionary: Pemigatinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-pd-1-monoclonal-antibody-mga012' target='_blank'>NCI Drug Dictionary: INCMGA00012</a> </li></ul>
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237

NEAREST SITE: 1478 miles
Mary Crowley Cancer Research
Dallas,TX

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT04332653

Immunotherapies Hyleukin-7 and Pembrolizumab for Advanced Triple Negative Breast Cancer

An Open-label Phase 1b/2a Study of NT-I7 (Hyleukin-7) in Combination With Pembrolizumab in Subjects With Relapsed/Refractory Advanced Solid Tumors Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of combining the experimental immunotherapy Hyleukin-7 with the PD-1 checkpoint inhibitor pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer whose disease progressed after receiving a PD-1/PD-L1 inhibitor.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Hyleukin-7 (NT-17), by injection, every 6 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hyleukin-7 (NT-17) is an experimental immunotherapy. This means it is only available in clinical trials. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking PD-1.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04332653' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='http://neoimmunetech.com/technology/page01.html' target='_blank'>NeoImmuneTech Drug Information Page: Hyleukin-7 (NT-17)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793669' target='_blank'>NCI Drug Dictionary: Efineptakin Alfa (Hyleukin-7)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor+PEMBROLIZUMAB+ONLY_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Generic+Keyword_General&kw=pembrolizumab&utm_kxconfid=sq7irm3mh&gclid=CjwKCAjwmMX4BRAAEiwA-zM4Jt_FsXjBbCDQmDpAauIhhxyGABNsAMua9ha' target='_blank'>Merck Oncology Drug Information Page: Keytruda® (Pembrolizumab)</a> </li></ul>
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238

NEAREST SITE: 1479 miles
Mary Crowley Cancer Research Centers
Dallas,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03150810

BGB-290 with Temozolomide for Advanced Breast Cancer

A Phase 1b Study to Assess the Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Subjects With Locally Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using an oral chemotherapy along with a new targeted drug to treat advanced breast cancer.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have not already received a PARP inhibitor. If you have triple negative (ER-, PR-, HER2-) breast cancer, you must have received less than three prior therapies for advanced disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BGB-290, by mouth</li> <li class="seamTextUnorderedListItem">Temolozomide, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two drugs being used in this study are temozolomide (Temodar) and BGB-290. </li> <li class="seamTextUnorderedListItem">Temodar is used to treat brain cancer. </li> <li class="seamTextUnorderedListItem">BGB-290 is a type of targeted therapy called a PARP inhibitor.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03150810' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a601250.html' target='_blank'>NIH MedlinePlus: Temozolomide</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.beigene.com/pipeline/clinical-candidates/bgb-290/' target='_blank'>Drug Company Information Page: BGB-290</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/temozolomide' target='_blank'>Cancer Research UK: Temozolomide</a> </li></ul>
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239

NEAREST SITE: 1481 miles
University of Texas-San Antonio
San Antonio,TX

VISITS: Visits 5 days a week for 3 weeks

PHASE: I-II

NCT ID: NCT01928589

Radiation & Chemotherapy Together or Sequentially for Stage I-II Breast Cancer

"Randomized Trial of Partial Breast Irradiation (PBI) and Sequential vs. Concurrent Chemotherapy in Women With ER Negative Early Stage Breast Cancer (PBI 3.0)" Scientific Title

Purpose
To compare the safety and effects (good and bad) of giving PBI radiation therapy and chemotherapy at the same to giving PBI radiation therapy followed by chemotherapy.
Who is this for?
Women with stage I or stage II breast cancer. You must not have yet received anti-cancer treatment including surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 following groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Concurrent</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PBI radiation therapy, 5 days a week</li> <li class="seamTextUnorderedListItem">Physician's choice chemotherapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Sequential</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PBI radiation therapy, 5 days a week</li> <li class="seamTextUnorderedListItem">followed by physician's choice chemotherapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Following surgery, patients typically receive radiation followed by chemotherapy.</li> <li class="seamTextUnorderedListItem">Previous studies suggest that giving radiation therapy and chemotherapy at the same time is also a safe and effective way to treat breast cancer.</li> <li class="seamTextUnorderedListItem">Partial-breast irradiation (PBI) is a type of radiation therapy given only to the area of the breast where the cancer was removed.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01928589' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/20110925b' target='_blank'>BreastCancer.org: Chemo and Radiation Therapy at Same Time</a> </li></ul>
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240

NEAREST SITE: 1481 miles
Mays Cancer Center, UT Health San Antonio
San Antonio,TX

VISITS: At least 1 visit

PHASE: NA

NCT ID: NCT02538484

Omega-3 Fatty Acid (Fish Oil) or Femara Before Surgery in Obese Women with ER+ Tumors

A Phase 0, Investigator Initiated Study, Evaluating the Impact of Omega 3 Fatty Acid Supplementation on Aromatase in Obese Postmenopausal Women With Estrogen Receptor Positive Breast Cancer Scientific Title

Purpose
To look at the effect that an omega-3 fatty acid (fish oil) supplement and an anti-estrogen breast cancer drug have on hormone-sensitive breast cancer cells.
Who is this for?
Women diagnosed with estrogen receptor positive (ER+) breast cancer who are postmenopausal and considered to be obese (body mass index ò 30).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Femara Only</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily for 1 month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Fish Oil Only</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Omega-3 Fatty Acid (fish oil), by mouth, daily for 1 month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Femara and Fish Oil</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Letrozole (Femara®) and Omega-3 Fatty Acids (fish oil), by mouth, daily for 1 month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Omega-3 fatty acids are not made by the body and are obtained only through foods or supplements. </li> <li class="seamTextUnorderedListItem">The omega-3 supplement being used in the study is fish oil. </li> <li class="seamTextUnorderedListItem">The anti-estrogen drug used in the study is letrozole (Femara®). It is used to treat postmenopausal women with hormone receptor positive (ER+ and/or PR+) breast cancer. </li> <li class="seamTextUnorderedListItem">Giving the treatments before surgery allows the researchers to study the effect they have on breast cancer cells.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02538484' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/view?cdrid=775881' target='_blank'>Cancer.gov: Trial Description</a> </li></ul>
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241

NEAREST SITE: 1481 miles
Novartis Investigative Site
San Antonio,TX

VISITS: 5 visits over the first 3 weeks, then one visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT02829723

BLZ945 Alone or With PDR001 For Metastatic Breast (and Other) Cancer

A Phase I/II, Open-label, Multi-center Study of the Safety and Efficacy of BLZ945 as Single Agent and in Combination With PDR001 in Adults Patients With Advanced Solid Tumors Scientific Title

Purpose
To investigate whether a new type of targeted cancer drug is safe and effective when it is given alone or with an immunotherapy drug.
Who is this for?
This study has two phases: Phase 1 is for people with any type of metastatic (stage iV) breast cancer; Phase II is for people with metastatic, triple negative breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive one of the following treatments: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BLZ945</li> </ul> <p class="seamTextPara"> or </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BLZ945 and PDR001</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <p class="seamTextPara"> The targeted drug being used in this study is called BLZ945. It targets a receptor called CSF1R that plays a role in tumor growth. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This is the first study to test this new targeted drug in cancer patients. </li> <li class="seamTextUnorderedListItem">Some patients who enroll in this study will also receive an immunotherapy drug called PDR001.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02829723' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=770801' target='_blank'>NCI Drug Dictionary: PDR001</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902121/' target='_blank'>OncoImmunology: CSF1R</a> </li></ul>
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242

NEAREST SITE: 1481 miles
NEXT Oncology /ID# 204893
San Antonio,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03595059

ABBV-155 for Advanced Breast (and Other) Cancers

A Phase 1 First-in-Human Study With ABBV-155 Alone and in Combination With Taxane Therapy in Adults With Relapsed and/or Refractory Solid Tumors Scientific Title

Purpose
To evaluate the safety of a new cancer drug ABBV-155 and to determine the best dose of the drug to use, and look at the effects (good and bad) of the best dose.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-155, by IV</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The experimental drug is called ABBV-155. It is only available in clinical trials. </li> <li class="seamTextUnorderedListItem">ABBV-155 will be given with paclitaxel (Taxol®) a drug approved to treat breast cancer. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03595059' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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243

NEAREST SITE: 1481 miles
NEXT Oncology /ID# 208930
San Antonio,TX

VISITS: 1 visit every month, ongoing

PHASE: I

NCT ID: NCT03821935

ABBV-151 and ABBV-181 for Advanced Triple Negative Breast Cancer

A Phase 1 First-in Human, Multi-Center, Open Label Dose-Escalation Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Subjects With Locally Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To investigate the safety, best dose and effects (good and bad) of ABBV-151 when it used with or without ABBV-181.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) that has been treated with at least one systemic therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of the 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-151, by IV, once a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-151, by IV, once a month, ongoing</li> <li class="seamTextUnorderedListItem">ABBV-181, by IV, once a month, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-151 is a targeted therapy that blocks a protein called GARP- TGF-β1. </li> <li class="seamTextUnorderedListItem">ABBV-181 is an experimental PD-1 inhibitor. This type of immunotherapy, called a checkpoint inhibitor, gets the immune system to see and go after cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03821935' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.abbvie.com/our-science/pipeline/abbv-151.html' target='_blank'>Drug company information page: ABBV-151</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/abbv-181/' target='_blank'>Immuno-oncology news: ABBV-181</a> </li></ul>
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244

NEAREST SITE: 1481 miles
South Texas Accelerated Research Therapeutics, LLC
San Antonio,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03875313

Telaglenastat and Talazoparib for Advanced Triple Negative Breast Cancer

A Phase 1b/2 Open Label, Dose Escalation and Expansion Study of the Glutaminase Inhibitor CB-839 in Combination With the PARP Inhibitor Talazoparib in Patients With Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To study the safety, best dose, and effects (good and bad) of CB-839 (Telaglenastat) when it is used along with talazoparib (Talzenna®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CB-839 (Telaglenastat), by mouth, twice daily, ongoing</li> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, twice daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CB-839 (Telaglenastat) is an investigational targeted therapy that blocks an enzyme called glutaminase. </li> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®) is a type of targeted therapy called a PARP inhibitor. It is approved to treat advanced HER2 negative breast cancer in people with an inherited BRCA mutation.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03875313' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-talazoparib-gbrcam-her2-negative-locally-advanced-or-metastatic-breast-cancer' target='_blank'>FDA: FDA approves talazoparib for gBRCAm HER2-negative locally advanced or metastatic breast cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/glutaminase-inhibitor-cb-839' target='_blank'>NCI Drug Dictionary: Glutaminase inhibitor CB-839</a> </li></ul>
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245

NEAREST SITE: 1481 miles
NEXT Oncology /ID# 210717
San Antonio,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03893955

ABBV-927 and ABBV-368 for Advanced Triple Negative Breast Cancer

A Phase 1, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 and ABBV-368 With and Without ABBV-181 in Subjects With Locally Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To study the safety and effects (good and bad) of using two experimental immunotherapies, ABBV-927 and ABBV-368, together.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) that has not been treated with an immunotherapy and that did not respond to at least one systemic therapy that included a taxane.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-927, by IV</li> <li class="seamTextUnorderedListItem">ABBV-368, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ABBV-927 is an immunotherapy that gets the immune system to go after cancer cells by targeting a protein called CD40. </li> <li class="seamTextUnorderedListItem">ABBV-368 is an immunotherapy that targets OX40, which is found on certain T cells. </li> <li class="seamTextUnorderedListItem">This study is also recruiting patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03893955' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cd40-agonist-monoclonal-antibody-abbv-927' target='_blank'>NCI Drug Dictionary: ABBV-927</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.abbvie.com/our-science/pipeline/abbv-368.html' target='_blank'>Drug company information page: ABBV-368</a> </li></ul>
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246

NEAREST SITE: 1481 miles
Mays Cancer Center, UT Health San Antonio
San Antonio,TX

VISITS: 2 visits every 3 weeks, ongoing

PHASE: NA

NCT ID: NCT03995706

A Targeted Therapy for Breast Cancer That Has Spread to the Brain

A Phase 0, Investigator Initiated Study to Determine the Bioavailability of Sacituzumab Govitecan in Breast Brain Metastasis and Glioblastoma Scientific Title

Purpose
To look at the safety of sacituzumab govitecan, an antibody-drug conjugate.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the brain and scheduled to have surgery to remove the tumors in your brain.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sacituzumab govitecan, by IV, 1 day before surgery, then 2 times every 3 weeks following surgery, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sacituzumab govitecan is an antibody-drug conjugate (ADC). </li> <li class="seamTextUnorderedListItem">These drugs combine an antibody that can target a cancer cell with an anti-cancer drug. </li> <li class="seamTextUnorderedListItem">The anti-cancer drug in sacituzumab govitecan is irinotecan, a chemotherapy drug used to treat many types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03995706' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Sacituzumab_govitecan' target='_blank'>Wikipedia: Sacituzumab Govitecan</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertodaymag.org/pages/Fall2015/Advances-Treating-Brain-Metastases.aspx' target='_blank'>Cancer Today: Breaking the Blood-Brain Barrier</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nejm.org/doi/full/10.1056/NEJMoa1814213' target='_blank'>The New England Journal of Medicine: Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer</a> </li></ul>
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247

NEAREST SITE: 1481 miles
NEXT Oncology
San Antonio,TX

VISITS: 1 visit per week, ongoing

PHASE: I-II

NCT ID: NCT04092673

eFT226 in Advanced Breast Cancer That Tests Positive for HER2, ERBB3, FGFR1, FGFR2, or KRAS Mutations

A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Intravenous eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of eFT226 (Zotatifin), an experimental targeted therapy that blocks eIF4A1.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that has been treated with standard therapies and tests positive for a mutation in HER2 (ERRB2), ERBB3, FGFR1, FGFR2, or KRAS.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">eFT226 (Zotatifin), by IV, weekly, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">eFT226 (Zotatifin) is an experimental targeted therapy that blocks eIF4A1. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of solid tumors that have these mutations.</li> <li class="seamTextUnorderedListItem">Targets or mutations: HER2 (ERBB2), ERBB3, FGFR1, FGFR2, or KRAS</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04092673' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.globenewswire.com/news-release/2019/11/05/1941103/0/en/eFFECTOR-Therapeutics-Initiates-Phase-1-2-Safety-and-Efficacy-Study-of-Zotatifin-eFT226-in-Patients-with-Advanced-Solid-Tumor-Malignancies.html' target='_blank'>Drug Company Press Release: eFT226 (Zotatifin)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/targeted-therapy-for-breast-cancer.html' target='_blank'>American Cancer Society: Targeted Therapies for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nature.com/articles/cddis2014542' target='_blank'>Journal Article: The Malignant Phenotype in Breast Cancer is Driven by eIF4A1-mediated Changes in The Translational Landscape</a> </li></ul>
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248

NEAREST SITE: 1481 miles
South Texas Accelerated Research Therapeutics, LLC
San Antonio,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04188548

LY3484356 Alone or With Abemaciclib in Advanced ER+, HER2- Breast Cancer

A Phase 1a/1b Study of LY3484356 Administered as Monotherapy and in Combination With Abemaciclib to Patients With ER+, HER2- Locally Advanced or Metastatic Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of LY3484356 when it is given alone or with abemaciclib (Verzenio®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer that has been treated with at least one standard of care therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3484356, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3484356, by mouth</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsies (tissue samples)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3484356 is an experimental drug. </li> <li class="seamTextUnorderedListItem">Verzenio® is a type of targeted therapy called a CDK 4/6 inhibitor. It is approved to treat metastatic ER positive and/or PR positive, HER2- breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04188548' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lillytrialguide.com/en-US/studies/breast-cancer/jzla' target='_blank'>Eli Lilly & Company Study Information</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verzenio.com/?utm_source=google&utm_medium=ppc&campaign=6456675261&adgroup=82640243172&ad=378689406880&utm_keyword=kwd-389189556877&gclid=CjwKCAiA1L_xBRA2EiwAgcLKA1TCNjqFBHZ6GUcDnbYuJPCiPuF9GkpS2yp7gF3j1LJCZnLEMhSm_RoCO0QQAvD_BwE' target='_blank'>Eli Lilly & Company Drug Information Page: Verzenio® (Abemaciclib)</a> </li></ul>
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249

NEAREST SITE: 1481 miles
South Texas Accelerated Research Therapeutics (START)
San Antonio,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04344795

TPST-1495 Alone or With Pembrolizumab for Advanced Triple Negative Breast Cancer

Phase 1a/1b Open Label Dose-escalation and Expansion Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors Scientific Title

Purpose
To study the safety, effects (good and bad), and best dose of TPST-1495 alone and in combination with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1495, by mouth, twice a day, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1495, by mouth, twice a day, ongoing</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TPST-1495 is an experimental (only available in clinical trials) targeted therapy.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking PD-1.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is approved to treat only certain types of breast cancer. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04344795' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/EmergingMetasticBreastCancer.html' target='_blank'>Susan G. Komen: Emerging Areas in Metastatic Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=CjwKCAjwv4_1BRAhEiwAtMDLsqE2Q3a74MSBt-Qt-jPAPtFkWZ4hjxPY6s9hW1c5ZyCjJkFSvzZULhoCbjYQA' target='_blank'>Merck Oncology Information Page: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tempesttx.com/file.cfm/33/docs/2019-sitc-poster-p311.pdf' target='_blank'>Drug Company Information Page: TPST-1495</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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250

NEAREST SITE: 1481 miles
The START Center for Cancer Care.
San Antonio,TX

VISITS: 1 visit every 3 weeks

PHASE: I

NCT ID: NCT04354246

An Experimental Targeted Therapy in Advanced Breast Cancer

A Phase 1 Study of The Safety and Tolerability of COM902 in Subjects With Advanced Malignancies Scientific Title

Purpose
To study the safety, best dose, and effects (good and bad) of COM902.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">COM902, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">COM902 is a type of targeted therapy called a TIGIT inhibitor. It is an experimental drug that is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04354246' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cgen.com/pipeline/immuno-oncology/cgen-15137tigit/' target='_blank'>Drug Company Information Page: COM902</a> </li></ul>
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251

NEAREST SITE: 1481 miles
South Texas Accelerated Research Therapeutics
San Antonio,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04389632

SGN-B6A in Advanced Breast Cancer

A Phase 1 Study of SGN-B6A in Advanced Solid Tumors Scientific Title

Purpose
To study the safety, side-effects, anti-cancer activity, and best dose of the antibody-drug conjugate SGN-B6A.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SGN-B6A, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SGN-B6A is an investigational therapy. This means it is only available in a clinical trial.</li> <li class="seamTextUnorderedListItem">An antibody-drug conjugate (ADC) is a cancer therapy that combines an antibody that targets cancer cells with a drug that can kill cancer cells.</li> <li class="seamTextUnorderedListItem">SGN-B6A is an antibody-drug conjugate (ADC) targeting integrin beta-6. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced or metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04389632' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://mbcn.org' target='_blank'>Metastatic Breast Cancer Network</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biospace.com/article/releases/seattle-genetics-announces-initiation-of-phase-1-clinical-trials-for-two-novel-antibody-based-drug-candidates/' target='_blank'>BioSpace Press Release: Seattle Genetics Announces Initiation of Phase 1 Clinical Trials for Two Novel Antibody-Based Drug Candidates</a> </li></ul>
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252

NEAREST SITE: 1481 miles
NEXT Oncology
San Antonio,TX

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT04441099

Targeted Therapy NBE-002 for Advanced Triple Negative Breast Cancer

A First-in-Human, Phase 1/2 Study of NBE-002, an Anti-ROR1 Antibody Drug Conjugate, in Patients With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, best dose, and anti-cancer activity of the experimental targeted therapy NBE-002.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have received no more than three therapies for advanced or metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NBE-002, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NBE-002 is a type of targeted therapy called an antibody-drug conjugate (ADC).</li> <li class="seamTextUnorderedListItem">Antibody-drug conjugates are cancer therapies that combine an antibody that targets cancer cells with a drug that can kill cancer cells.</li> <li class="seamTextUnorderedListItem">Because the antibody only targets cancer cells, the drug does not kill normal cells, making it less likely to cause side effects.</li> <li class="seamTextUnorderedListItem">The antibody in NBE-002 targets ROR1 proteins. </li> <li class="seamTextUnorderedListItem">NBE-002 delivers an anthracycline-based chemotherapy. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: ROR1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04441099' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://cancerres.aacrjournals.org/content/79/13_Supplement/LB-197' target='_blank'>AACR Abstract: NBE-002</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Antibody-drug_conjugate' target='_blank'>Wikipedia: Antibody-Drug Conjugate</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2019/05/01/mbc-news-11/' target='_blank'>MetastaticTrialTalk: Getting to the Target, Antibody Drug Conjugates in Breast Cancer</a> </li></ul>
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253

NEAREST SITE: 1481 miles
Investigative Site
San Antonio,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04460456

SBT6050 for Advanced HER2 Expressing Breast Cancer

A Phase 1/1B, Open-Label, Dose Escalation and Expansion Study of SBT6050 in Subjects With Advanced Solid Tumors Expressing HER2 Scientific Title

Purpose
To study the best dose, safety, side effects, and anti-cancer activity of the experimental targeted therapy SBT6050.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 expressing (IHC 2+ or 3+) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SBT6050, by IV, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HER2 expressing cancer is IHC 2+ or 3+.</li> <li class="seamTextUnorderedListItem">SBT6050 is an antibody-drug conjugate (ADC). A type of cancer therapy that combines an antibody that targets cancer cells with a drug that can kill cancer cells.</li> <li class="seamTextUnorderedListItem">Because the antibody only targets cancer cells, the drug does not kill normal cells, making it less likely to cause side effects.</li> <li class="seamTextUnorderedListItem">SBT6050 may also stimulate your immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of HER2 expressing cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04460456' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://silverbacktx.com' target='_blank'>Silverback Therapeutics Drug Information Page: SBT6050</a> </li></ul>
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254

NEAREST SITE: 1482 miles
Texas Oncology-Baylor -Charles A. Sammons Cancer Center
Dallas,TX

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03094169

AVID100 in Advanced Triple Negative Breast Cancer That Tests Positive for EGFR

Phase 1a/2a Dose Escalation Trial to Determine Safety, Tolerance, MTD, and Preliminary Antineoplastic Activity of AVID100, in Patients With Advanced or Metastatic Solid Tumors of Epithelial Origin Scientific Title

Purpose
To determine the safety and effects (good and bad) of using an experimental targeted therapy called AVID100.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR-, HER2-) that has not responded to other treatment options and tests positive for EGFR over-expression.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AVID100 IV, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AVID100 is a targeted antibody-drug conjugate (ADC). </li> <li class="seamTextUnorderedListItem">It targets EGFR proteins to deliver a chemotherapy drug called maytansinoid mertansine (DM1).</li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: EGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03094169' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/792639' target='_blank'>NCI Drug Dictionary: AVID100</a> </li></ul>
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255

NEAREST SITE: 1482 miles
Baylor University Medical Center
Dallas,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03193853

Targeted therapy followed by Chemotherapy for Metastatic Triple Negative Breast Cancer

Phase II Clinical Trial of Treatment With TAK-228 and TAK-117 to Inhibit Homologous Recombination (HR) Followed by Cisplatin and Nab Paclitaxel in Patients With Chemotherapy-pretreated Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of using two targeted drugs (TAK-228 and TAK-117) followed by chemotherapy.
Who is this for?
Women with triple negative metastatic (stage IV) breast cancer. Your tumor must test negative for androgen receptors. In addition, you must have already had chemotherapy (anthracycline, cyclophosphamide, and taxane).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TAK-228 and TAK-117, by mouth, until disease progression</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cisplatin (Paraplatin®) and nab-paclitaxel (Abraxane®), by IV, as long as benefit is shown</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The targeted drugs used in this study are TAK-228 and TAK-117. Both are mTOR inhibitors. </li> <li class="seamTextUnorderedListItem">mTOR is a kinase, a type of protein found in the body. Kinases help all cells -- both healthy and cancerous – get the energy they need. When kinases don’t act normally or are overactive, they help certain breast cancers grow. mTOR inhibitors interfere with the mTOR kinase, which stops cancer cells from getting the energy they need to grow. (Breastcancer.org)</li> <li class="seamTextUnorderedListItem">Cisplatin (Paraplatin®) and nab-paclitaxel (Abraxane®) are the chemotherapy drugs used in this study.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03193853' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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256

NEAREST SITE: 1482 miles
10 sites incl TX, WA, VA, and NV
Dallas,TX

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03379428

Ibrutinib and Herceptin in HER2+ Advanced Breast Cancer

Phase I/II Trial of Ibrutinib Plus Trastuzumab in HER2-amplified Metastatic Breast Cancer Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using an experimental therapy along with trastuzumab (Herceptin®).
Who is this for?
Women with metastatic (stage IV) breast cancer that is HER2 positive. Your tumor must have progressed while you were receiving T-DM1 (kadcyla) anti-HER2 therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Ibrutinib (Imbruvica®), by mouth, daily</li></ul>
  • <p class="seamTextPara"> Ibrutinib (Imbruvica) is the experimental targeted therapy being used in this study. It is currently approved for treating certain types of blood cancers. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Herceptin is a targeted therapy used to treat HER2-positive breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03379428' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/inside-oncology/cll-therapeutic-management/cll-the-biologics-of-ibrutinib-therapy' target='_blank'>OncLive: Ibrutinib</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/targeted_therapies' target='_blank'>Breastcancer.org Targeted Therapy</a> </li></ul>
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257

NEAREST SITE: 1482 miles
Texas Oncology- Baylor
Dallas,TX

VISITS: 1 visit every 3 weeks for 4.5 months

PHASE: II

NCT ID: NCT03639948

Immunotherapy and Chemotherapy Before Surgery to Treat Triple Negative Breast Cancer

Neoadjuvant Phase II Study of Pembrolizumab And Carboplatin Plus Docetaxel in Triple Negative Breast Cancer (NeoPACT) Scientific Title

Purpose
To study the effect of using the immunotherapy pembrolizumab (Keytruda®) along with chemotherapy before surgery (neoadjuvant therapy).
Who is this for?
People with stage I, II or III triple-negative (ER-/PR-/HER2-) breast cancer who have not yet started treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV</li> <li class="seamTextUnorderedListItem">Pegfilgrastim, by injection </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">All medications are given once every 3 weeks, for 4.5 months</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">It stimulates the body's immune system to go after cancer cells. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) and docetaxel (Taxotere®) are chemotherapy drugs used to treat triple negative breast cancer. </li> <li class="seamTextUnorderedListItem">Pegfilgrastim is a human granulocyte colony-stimulating factor (GCSF). It is given along with chemotherapy to reduce the risk of neutropenia (low white blood cell count) and infection.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03639948' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/immunotherapy-remains-focal-point-in-tnbc' target='_blank'>OncLive: Immunotherapy Remains Focal Point in TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/issues/july-10-2017/pembrolizumab-moving-forward-in-triple-negative-breast-cancer/' target='_blank'>ASCO: Pembrolizumab Moving Forward in Triple-Negative Breast Cancer</a> </li></ul>
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258

NEAREST SITE: 1482 miles
Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas,TX

VISITS: 1 visit every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03952325

Tesetaxel and Immunotherapy in Advanced HER2- Breast Cancer

A Multicenter, Phase 2 Study of Tesetaxel Plus 3 Different PD-(L)1 Inhibitors in Patients With Metastatic TNBC and Tesetaxel Monotherapy in Elderly Patients With HER2 Negative MBC (CONTESSA TRIO) Scientific Title

Purpose
To compare the safety and effects (good and bad) of an experimental oral chemotherapy drug called tesetaxel when it is given with one of three immunotherapy drugs as well as the safety and effects of tesetaxel when it is given alone.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) who have not received prior chemotherapy for advanced disease; or people, 65 or older, who have advanced or metastatic HER2 negative breast cancer and have not received prior chemotherapy for advanced disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> <u>Cohort 1:</u> </p> <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel, by mouth, every 3 weeks</li> <li class="seamTextUnorderedListItem">Nivolumab, by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel, by mouth, every 3 weeks</li> <li class="seamTextUnorderedListItem">Pembrolizumab, by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel, by mouth, every 3 weeks</li> <li class="seamTextUnorderedListItem">Atezolizumab, by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <u>Cohort 2:</u> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">For over 65 years old with HER2 negative breast cancer</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel, by mouth, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">To take part in the first cohort, you must have advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) and have not received prior chemotherapy for advanced disease. </li> <li class="seamTextUnorderedListItem">To be part of the second cohort, you must be age 65 or older, have advanced or metastatic HER2 negative breast cancer, and have not received prior chemotherapy for advanced disease. </li> <li class="seamTextUnorderedListItem">In the first cohort, this study is comparing the safety and effects (good and bad) of an experimental oral chemotherapy drug called tesetaxel when it is given with one of three immunotherapy drugs. </li> <li class="seamTextUnorderedListItem">In the second cohort, the study is investigating the safety and effects (good and bad) of tesetaxel when it is given alone. </li> <li class="seamTextUnorderedListItem">The three immunotherapy drugs being used in this study are nivolumab (Opdivo®), pembrolizumab (Keytruda®), and atezolizumab (Tecentriq®). </li> <li class="seamTextUnorderedListItem">Opdivo and Keytruda are PD-1 inhibitors. They get the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). Both are approved for certain types of cancers. Their use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Tecentriq is a PD-L1 inhibitor. It gets the immune system to go after cancer cells by blocking PD-L1. </li> <li class="seamTextUnorderedListItem">Tecentriq in combination with Abraxane is an FDA-approved treatment for metastatic triple negative breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03952325' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/issues/july-25-2018/oral-taxane-shows-strong-activity-and-good-tolerability-in-metastatic-breast-cancer/' target='_blank'>ASCO post: Oral Taxane Shows Strong Activity and Good Tolerability in MBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/peer-exchange/unmet-needs-mbc/tesetaxel-an-oral-taxane-for-hr-positive-mbc' target='_blank'>OncLive: Tesetaxel: An Oral Taxane for HR-Positive mBC</a> </li></ul>
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259

NEAREST SITE: 1482 miles
Baylor Scott and White University Medical Center
Dallas,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT04032080

LY3023414 Followed by Prexasertib in Metastatic Triple Negative Breast Cancer

Pilot Clinical Trial Of Treatment With Oral LY3023414 To Inhibit Homologous Recombination (HR) Followed By Prexasertib In Patients With Chemotherapy-Pretreated Metastatic Triple Negative Breast Cancer (ExIST) Scientific Title

Purpose
To look at the safety and effects (good and bad) of treating patients with the investigational targeted therapy LY3023414 followed by the investigational targeted therapy prexasertib.
Who is this for?
Women with metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer who have not had more than 3 chemotherapy regimens.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3023414, by mouth, twice a day, until disease progression </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Prexasertib, by IV, every 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3023414 is a type of targeted therapy called a PI3K/mTOR inhibitor. </li> <li class="seamTextUnorderedListItem">Prexasertib is a targeted therapy that blocks checkpoint kinase1 (chk1), which plays a role in chemotherapy drug resistance.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04032080' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/prexasertib' target='_blank'>NCI Drug Dictionary: Prexasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pi3k-mtor-inhibitor-ly3023414' target='_blank'>NCI Drug Dictionary: LY3023414</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.1064' target='_blank'>Journal of Clinical Oncology: Safety and tolerability of LY3023414 in combination with fulvestrant in treatment refractory advanced breast cancer</a> </li></ul>
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260

NEAREST SITE: 1494 miles
The University of Kansas Cancer Center, West Clinic
Kansas City,KS

VISITS: 1 visit every 3 weeks, for 5 months

PHASE: II

NCT ID: NCT03238495

Chemotherapy plus Metformin Before Surgery for HER2 Positive Breast Cancer

Randomized Trial of Neo-adjuvant Chemotherapy With or Without Metformin for HER2 Positive Operable Breast Cancer Scientific Title

Purpose
To study whether a current standard treatment given before surgery achieves a better response (the tumor shrinks more) when the drug metformin is added to the regimen.
Who is this for?
Women who completed chemotherapy and/or radiation treatment for stage I, stage II, or stage III breast cancer within the past 5 years.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and receive the following before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TCHP chemotherapy (docetaxel/Taxotere®, carboplatin/Paraplatin®, trastuzumab/Herceptin®, pertuzumab/Perjeta®), by IV, every 3 weeks, for 5 months</li> <li class="seamTextUnorderedListItem">Metformin, daily, for 5 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TCHP chemotherapy (docetaxel/Taxotere®, carboplatin/Paraplatin®, trastuzumab/Herceptin®, pertuzumab/Perjeta®), by IV, every 3 weeks, for 5 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The standard therapy used in this study is called TCHP chemotherapy--docetaxel/Taxotere®, carboplatin/Paraplatin®, trastuzumab/Herceptin®, pertuzumab/Perjeta®. </li> <li class="seamTextUnorderedListItem">Studies have suggested metformin, which is used to treat diabetes, may slow tumor growth.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03238495' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/web-exclusives/tchp-still-standard-choice-for-patients-with-her2-breast-cancer' target='_blank'>OncLive: TCH+P Still Standard Choice for HER2+ Breast Cancer</a> </li></ul>
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261

NEAREST SITE: 1494 miles
The University of Kansas Cancer Center, West Clinic
Kansas City,KS

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03709082

Palbociclib, Letrozole and T-DM1 in ER Positive and HER2 Positive Metastatic Breast Cancer

A Phase I/II Study of Palbociclib, Letrozole and T-DM1 in Trastuzumab Refractory Estrogen Receptor Positive (ER+) and HER2 Positive Metastatic Breast Cancer Scientific Title

Purpose
To determine the best dose of palbociclib (Ibrance®) to use when it is given along with letrozole (Femara®) and T-DM1 (Kadcyla®).
Who is this for?
Women with ER positive and HER2 positive metastatic (stage IV) breast cancer and have been treated with a taxane and trastuzumab (Herceptin®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, once daily</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, once daily</li> <li class="seamTextUnorderedListItem">T-DM1(Kadcyla®), by IV, once every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ibrance is a type of targeted therapy called a CDK 4/6 inhibitor. It is used along with certain hormonal therapies to treat ER positive and HER2 negative metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Femara is an aromatase inhibitor used to treat hormone-sensitive tumors in postmenopausal women. </li> <li class="seamTextUnorderedListItem">Kadcyla is used to treat HER2-positive metastatic breast cancer. It combines the chemotherapy drug DM1 with the HER2-targeted drug trastuzumab (Herceptin®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03709082' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pfizeroncologytogether.com/patient/ibrance/patient-financial-assistance?source=google&HBX_PK=s_ibrance&skwid=43700026569998730&cmp=353c6806-b5f2-46a9-afb6-d8080bcdf84d' target='_blank'>pfizer Oncology: Ibrance</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-4297/letrozole-oral/details' target='_blank'>WebMD: Letrozole</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20131001' target='_blank'>Breastcancer.org: Kadcyla</a> </li></ul>
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262

NEAREST SITE: 1499 miles
The University of Kansas Cancer Center - Overland Park
Overland Park,KS

VISITS: 2 visits per month, ongoing

PHASE: II

NCT ID: NCT03147287

Ibrance, Bavencio and Faslodex for Previously Treated ER+, HER2- Advanced Breast Cancer

Palbociclib After CDK and Endocrine Therapy (PACE): A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab for Endocrine Pre-treated ER+/HER2- Metastatic Breast Cancer Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using fulvestrant (Faslodex®) alone, in combination with Ibrance®, or in combination with Ibrance and an immunotherapy agent (Bavencio®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that is estrogen receptor positive and HER2 negative. You must have already been treated with a CDK4/6 inhibitor in combination with an anti-estrogen therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice a month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice a month</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, once daily (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice a month</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, once daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, twice monthly</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Faslodex is the anti-estrogen drug used in this study. Palbociclib (Ibrance®) is approved to treat HR+, HER2-negative breast cancer in combination with an anti-estrogen therapy. </li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®) is a type of immunotherapy called a PD-L1 inhibitor. It is approved to treat a type of blood cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03147287' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://externalmediasite.partners.org/Mediasite/Play/ae54eaa1a0fc497d8e4db9135bc857ca1d' target='_blank'>Dana-Farber Cancer Institute: Patient-friendly informational video about this trial</a> </li></ul>
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263

NEAREST SITE: 1500 miles
University of Kansas Medical Center
Kansas City,KS

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT00291096

Assessment of Individual Risk in High-Risk Women

High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast Cancer Scientific Title

Purpose
To develop a system of breast cancer risk assessment as well as to determine the best biomarkers (biological markers) for predicting and monitoring response to prevention interventions.
Who is this for?
Women age 30 to 65 with at least 2 times the normal risk of developing breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Tissue samples</li> <li class="seamTextUnorderedListItem">Mammogram </li> <li class="seamTextUnorderedListItem">Random periareolar fine needle aspiration (RPFNA)</li> <li class="seamTextUnorderedListItem">Possible genetic testing</li> </ul> <p class="seamTextPara"> This is a prospective study, in which the researchers will be in contact with you for a number of years after you undergo initial testing and will want to know if you go on to develop breast cancer.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doctors are trying to determine the best protocols for following women who are known to be at high risk for developing breast cancer. </li> <li class="seamTextUnorderedListItem">The doctors will evaluate many factors, including new breast tissue biomarkers, mammographic breast density, blood levels of estrogens, proteins found in breast cells and nipple fluid, and hormone levels. </li> <li class="seamTextUnorderedListItem">This is a prospective study. This means the researchers will maintain contact with the research participants for a number of years, as they are interested in knowing who goes on to develop breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00291096' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/Cancer/BreastCancer/DetailedGuide/breast-cancer-risk-factors' target='_blank'>American Cancer Society: Risk Factors</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/risk/understand/your_risk.jsp' target='_blank'>BreastCancer.org: Your Risk</a> </li></ul>
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264

NEAREST SITE: 1500 miles
University of Kansas Medical Center
Kansas City,KS

VISITS: Daily visits for 1 month

PHASE: NA

NCT ID: NCT02958774

Hypofractionated Radiation To Treat Regional Lymph Nodes to Reduce Lymphedema Risk

Hypofractionated Radiation Therapy for Patients With Breast Cancer Receiving Regional Nodal Irradiation Scientific Title

Purpose
To learn whether hypofractionated radiation therapy is less likely to cause lymphedema than conventional radiation therapy.
Who is this for?
Women with stage II or stage III breast cancer that has spread to the lymph nodes (node positive) who will be treated with radiation after breast cancer surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy, daily, for 1 month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a swelling of the soft tissues in the arm and hand caused by a build-up of lymph fluid. </li> <li class="seamTextUnorderedListItem">Radiation therapy to the lymph nodes can result in scar tissue that blocks the lymph flow, increasing risk for lymphedema. </li> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy is a type of radiation therapy that is given at a higher dose over a shorter period of time than standard radiation therapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02958774' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hypofractionated-radiation-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Hypofractionated radiation therapy</a> </li></ul>
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265

NEAREST SITE: 1500 miles
University of Kansas Medical Center/ Cancer Center
Kansas City,KS

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03460067

Radiation or No Radiation For HER2 Positive Stage I-II Breast Cancer

Selective Use of Observation After Lumpectomy and Sentinel Lymph Node Biopsy in Her-2 Positive Patients With Pathologic Complete Response to Neoadjuvant Chemotherapy Scientific Title

Purpose
To see if radiation therapy helps prevent the cancer from coming back (recurrence).
Who is this for?
Women 50 or older with HER2 positive stage I or stage II breast cancer who received a treatment regimen that included trastuzumab (Herceptin®) before surgery and who intends to be treated with Herceptin after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following based on the results of your surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Experimental (if pathologic complete response (pCR) after surgery)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation (please contact research site for treatment schedule); or</li> </ul> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No radiation (if you agree)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Standard treatment (if no pathologic complete response (pCR) after surgery)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation (please contact research site for treatment schedule)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is looking at whether radiation therapy helps prevent the cancer from coming back (recurrence) in patients with stage I or stage II HER-2 positive early-stage breast cancer who had a complete response (no signs of cancer cells) after neoadjuvant treatment (therapy before surgery).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03460067' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/survival-better-if-neoadjuvant-chemo-clears-nodes' target='_blank'>Breastcancer.org: pCR</a> </li></ul>
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266

NEAREST SITE: 1502 miles
The University of Kansas Cancer Center
Westwood,KS

VISITS: Visits every 2 weeks for 1.5 months, then monthly, ongoing

PHASE: II

NCT ID: NCT02632045

Ribociclib and Faslodex for HR+, HER2- Advanced Breast Cancer

A Randomized Phase II Trial of Fulvestrant With or Without Ribociclib After Progression on Aromatase Inhibition Plus Cyclin-dependent Kinase 4/6 Inhibition in Patients With Unresectable or Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer Scientific Title

Purpose
To compare the safety and effectiveness of Faslodex and ribocicilib to Faslodex alone for treating HR+, HER2- advanced breast cancer.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that is estrogen receptor positive and HER2 negative. You must not have received more than one prior systemic chemotherapy for advanced or metastatic breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, every 2 weeks for 1.5 months, then monthly</li> <li class="seamTextUnorderedListItem">Ribociclib (LEE011), by mouth, daily, 3 weeks on and 1 week off</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, every 2 weeks for 1.5 months, then monthly</li> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily, 3 weeks on and 1 week off</li></ul>
  • <p class="seamTextPara"> Ribociclib (LEE011) is a type of targeted therapy called a cyclin-dependent kinase (CDK) inhibitor. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LEE011 works by inhibiting two enzymes, CDK4 and CDK6. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is an anti-estrogen therapy used to treat advanced breast cancer in postmenopausal women.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02632045' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02632045' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689330' target='_blank'>NCI Drug Dictionary: Ribociclib</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/hormonal/erds/faslodex' target='_blank'>Breastcancer.org: Faslodex</a> </li></ul>
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267

NEAREST SITE: 1506 miles
HCA Midwest Division
Kansas City,MO

VISITS: 2 visits every 3 weeks

PHASE: III

NCT ID: NCT03371017

Atezolizumab plus Chemotherapy for Early Relapsing Recurrent Triple Negative Breast Cancer

A Phase III, Randomised, Double-Blind, Placebo-Controlled, Multicentre Study Of The Efficacy And Safety Of Atezolizumab Plus Chemotherapy For Patients With Early Relapsing Recurrent (Inoperable Locally Advanced Or Metastatic) Triple-Negative Breast Cancer Scientific Title

Purpose
To determine the safety and effects (good and bad) of giving chemotherapy with an immunotherapy agent to giving chemotherapy alone for advanced breast cancer.
Who is this for?
People with triple negative (ER-/PR-/HER2-) advanced (some stage III) or metastatic (stage IV) breast cancer. You must not have received any prior anti-cancer therapy for stage III or stage IV breast cancer. Your cancer must have progressed within 1 year from receiving treatment for early stage breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Immunotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) by IV, once every 3 weeks </li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®) by IV, twice every 3 weeks </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, twice every 3 weeks </li> <li class="seamTextUnorderedListItem">Capacitabine (Xeloda®), by mouth, daily, for 2 weeks, followed by a 7-day rest period </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Placebo</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo by IV, once every 3 weeks </li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®) by IV, twice every 3 weeks </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, twice every 3 weeks </li> <li class="seamTextUnorderedListItem">Capacitabine (Xeloda®), by mouth, daily, for 2 weeks, followed by a 7-day rest period</li></ul>
  • <p class="seamTextPara"> The immunotherapy drug being used in this study is atezolizumab (Tecentriq®). </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The chemotherapy drugs used in this study are gemcitabine (Gemzar®), carboplatin (Paraplatin®) and capecitabine (Xeloda®). </li> <li class="seamTextUnorderedListItem">Gemzar is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Paraplatin is a platinum-based chemotherapy drug that is commonly used to treat triple negative breast cancer. </li> <li class="seamTextUnorderedListItem">Xeloda is commonly used to treat metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03371017' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/immunotherapy/what' target='_blank'>Breastcancer.org: What is Immunotherapy?</a> </li></ul>
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268

NEAREST SITE: 1509 miles
The University of Texas Southwestern Medical Center
Dallas,TX

VISITS: 1 visit

PHASE: I

NCT ID: NCT02685332

Cyberknife Radiation After Surgery for DCIS or Stage I-II Breast Cancer

Phase I Dose Escalation Trial of Single Fraction Adjuvant Stereotactic Body Partial Breast Irradiation (SB-PBI) For Early Stage Breast Cancer Scientific Title

Purpose
To learn whether it is safe to use a type of radiation called Cyberknife® to treat breast cancer. The study will also help researchers learn the best dose of Cyberknife radiation to use.
Who is this for?
Women diagnosed with DCIS (ductal carcinoma in situ) or stage I or stage II breast cancer. You must have had a lumpectomy (breast conserving surgery) and be planning to have radiation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive one CyberKnife radiation treatment.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation is used after surgery to kill any breast cancer cells that may be left in the breast. </li> <li class="seamTextUnorderedListItem">Cyberknife radiation is a type of radiation treatment that delivers a high dose of radiation over a short period of time to a targeted area.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02685332' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cyberknife.com/cyberknife-overview/how-unique.aspx' target='_blank'>CyberKnife®</a> </li></ul>
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269

NEAREST SITE: 1509 miles
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas,TX

VISITS: Number of visits unavailable, over 7 weeks

PHASE: II

NCT ID: NCT03747042

Letrozole Before Surgery for Post-Menopausal Stage I-III ER-Positive Breast Cancer

Pre-Surgical Trial of Letrozole in Post-Menopausal Patients With Operable Hormone-Sensitive Breast Cancer Scientific Title

Purpose
To look at the effects letrozole (Femara®) has on cancer cells.
Who is this for?
Postmenopausal women with ER positive HER2 negative stage I, stage II or stage III breast cancer who are going to have breast cancer surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, once daily, for 7 weeks before surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Femara® is a hormone therapy used to treat hormone-sensitive breast cancer. </li> <li class="seamTextUnorderedListItem">Giving a drug before surgery allows researchers to see the effect that it has on cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03747042' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/druglist/femara' target='_blank'>Breastcancer.org: Femara</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.uptodate.com/contents/neoadjuvant-management-of-newly-diagnosed-hormone-positive-breast-cancer' target='_blank'>UpToDate: Neoadjuvant management of newly diagnosed HR-positive breast cancer</a> </li></ul>
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270

NEAREST SITE: 1509 miles
University of Texas Southwestern Medical Center
Dallas,TX

VISITS: 1 visit every 2 weeks, ongoing

PHASE: II

NCT ID: NCT03789110

Nivolumab Plus Ipilimumab in Metastatic Hypermutated HER2 Negative Breast Cancer

NIMBUS: A Phase II Study of Nivolumab Plus Ipilimumab in Metastatic Hypermutated HER2-negative Breast Cancer (NIMBUS) Scientific Title

Purpose
To test the safety and effects (good and bad) of using two immunotherapy drugs in combination to treat metastatic breast cancer.
Who is this for?
People with HER2 negative metastatic (stage IV) breast cancer that is hypermutated (found to have at least 10 mutations per megabase) on a 300 gene panel test such as Foundation One, Oncopanel, or IMPACT.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®), by IV, every 6 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®) is a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). </li> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®) gets the immune system to go after cancer cells by blocking a protein called CTLA-4. </li> <li class="seamTextUnorderedListItem">Yervoy and Opdivo are used in combination to treat patients with melanoma and certain other cancers. </li> <li class="seamTextUnorderedListItem">Their use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03789110' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.opdivo.com/' target='_blank'>Bristol‑Myers Squibb Information Page: Opdivo</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.yervoy.com/' target='_blank'>Bristol‑Myers Squibb Information Page: Yervoy</a> </li></ul>
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271

NEAREST SITE: 1509 miles
UT Southwestern
Dallas,TX

VISITS: 4 visits the first month, then 1 visit a month, ongoing

PHASE: II

NCT ID: NCT04024436

TAS-120 (Futibatinib) for Advanced HER2 Negative Breast Cancer with FGFR Amplification

A Phase 2 Study of TAS-120 in Metastatic Breast Cancers Harboring Fibroblast Growth Factor Receptor (FGFR) Amplifications Scientific Title

Purpose
To study the safety and anti-cancer activity of the FGFR inhibitor TAS-120 (futibatinib).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer that tests positive for certain FGFR gene amplifications. You must have already received at least one treatment for advanced disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups depending on the hormone status of your cancer: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Hormone negative</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TAS-120 (futibatinib), by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Hormone positive</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TAS-120 (futibatinib), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, monthly, ongoing</li> <li class="seamTextUnorderedListItem">Goserelin (Zoladex®), by injection, monthly, ongoing ( only if you are premenopausal)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TAS-120 (futibatinib) is a type of targeted therapy called a kinase inhibitor. </li> <li class="seamTextUnorderedListItem">It is designed to block the FGFR (fibroblast growth factor receptor) protein.</li> <li class="seamTextUnorderedListItem">Targets or mutations: FGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04024436' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fgfr-inhibitor-tas-120' target='_blank'>NCI Drug Dictionary: Futibatinib</a> </li><li class='seamTextUnorderedListItem'><a href='http://targetedcancercare.massgeneral.org/My-Trial-Guide/Diseases/Breast-Cancer/FGFR-1,-2,-3-and-4.aspx' target='_blank'>Massachusetts General Hospital Cancer Canter: Breast Cancer, FGFR</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.faslodex.com/home.html' target='_blank'>AstraZeneca Drug Information Page: (Faslodex®) Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/hormone-therapy/goserelin-zoladex' target='_blank'>Breast Cancer Now: Goserelin</a> </li></ul>
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272

NEAREST SITE: 1509 miles
University of Texas Southwestern Medical Center
Dallas,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT04041128

PARP Inhibitor Before Surgery in Women with Triple Negative Breast Cancer & Inherited BRCA1/2 Mutation

Pre-Surgical Window Pilot Investigation of the Effect of PARP Inhibition on the Cellular and Molecular Changes in Primary Ovarian and Breast Cancer Scientific Title

Purpose
To study the effect that olaparib (Lynparza®) has on breast cancer cells when it is given before surgery.
Who is this for?
Women with stage I, stage II, or stage III triple negative (ER-, PR- and HER2-) breast cancer who have an inherited BRCA 1/2 mutation and who have not received any other breast cancer therapies.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily, for 7 days before surgery</li> <li class="seamTextUnorderedListItem">1 biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lynparza is a PARP inhibitor that is approved to treat HER2-negative metastatic breast cancer in women with an inherited BRCA mutation. </li> <li class="seamTextUnorderedListItem">This study is also enrolling women with ovarian cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04041128' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparza.com/breast-cancer/how-lynparza-treats-breast-cancer.html' target='_blank'>AstraZeneca Drug Information Page: Lynparza® (Olaparib)</a> </li></ul>
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273

NEAREST SITE: 1562 miles
Highlands Oncology Group
Fayetteville,AR

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02938442

Vaccine Plus Chemotherapy Before Surgery in Triple Negative Breast Cancer

A Combined Phase II Efficacy Study of a Carbohydrate Mimotope-based Vaccine With MONTANIDE ISA 51 VG Combined With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer Scientific Title

Purpose
To compare the safety and effects of an investigational vaccine along with chemotherapy to chemotherapy alone when given before surgery (neoadjuvant therapy).
Who is this for?
Women with stage II or III triple negative breast cancer (ER-, PR- and HER2-) who are going to be treated with standard chemotherapy before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups in a 2:1 ratio (twice as many participants will be in Group 1 as compared to Group 2). Treatment will be given before surgery. </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemovax (P10s-PADRE with MONTANIDEâ„¢ ISA 51 VG)</li> <li class="seamTextUnorderedListItem">Standard Chemotherapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard Chemotherapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The vaccine, P10s-PADRE, is a peptide-based vaccine that is designed to enhance the immune response and potentially attack tumors. </li> <li class="seamTextUnorderedListItem">It is given along with Montanide ISA 51 VG, which is designed to enhance an immune response by stimulating cytotoxic T-lymphocytes.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02938442' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/mimotope-p10s-padre-peptide-vaccine' target='_blank'>NCI Drug Dictionary: mimotope-P10s-PADRE peptide vaccine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/montanide-isa-51-vg' target='_blank'>NCI Drug Dictionary: Montanide ISA 51 VG</a> </li></ul>
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274

NEAREST SITE: 1562 miles
Highlands Oncology Group
Fayetteville,AR

VISITS: 1 visit every 3 weeks, ongoing

PHASE: III

NCT ID: NCT04208178

Alpelisib for Advanced HER2+ Breast Cancer with a PIK3CA Mutation

EPIK-B2: A Two Part, Phase III, Multicenter, Randomized (1:1), Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA Mutation Scientific Title

Purpose
To study the best dose and anti-cancer activity of combining the PI3K inhibitor alpelisib (Piqray®) with the anti-HER2 therapies trastuzumab (Herceptin®) and pertuzumab (Perjeta®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+) breast cancer that tests positive for a PIK3CA mutation. You must have already received chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, once every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, once every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, once every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, once every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®) is a targeted therapy called a PI3K inhibitor. </li> <li class="seamTextUnorderedListItem">If there is a mutation in the PIK3CA gene, the PI3K pathway can become overactivated, which allows cancer cells to grow. </li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®) blocks the PI3K pathway. </li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®) and trastuzumab (Herceptin®) are HER2-targeted therapies used to treat early-stage and metastatic HER2 positive (HER2+) breast cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04208178' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/piqray' target='_blank'>Breastcancer.org: Alpelisib (Piqray®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancernetwork.com/view/alpelisib-changing-clinical-landscape-breast-cancer-treatment' target='_blank'>Cancer Network: Alpelisib Is Changing the Clinical Landscape in Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2020/tucatinib-trastuzumab-deruxtecan-her2-positive-metastatic-breast-cancer' target='_blank'>NCI Cancer Currents Blog: For Metastatic HER2-Positive Breast Cancer, New Treatments Emerge</a> </li></ul>
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275

NEAREST SITE: 1591 miles
Cox Medical Center
Springfield,MO

VISITS: 1 visit every 3 weeks, ongoing

PHASE: III

NCT ID: NCT03671044

Comparing an Experimental form of Docetaxel to Standard Docetaxel in Women with Advanced Triple Negative Breast Cancer

A Global, Multicenter, Three Arms, Open-label Randomized Study to Evaluate the Efficacy and Safety of Nanosomal Docetaxel Lipid Suspension Compared to Taxotere® (Docetaxel Injection Concentrate) in Triple-negative Breast Cancer Patients With Locally Advanced or Metastatic Breast Cancer After Failure to Prior Chemotherapy Scientific Title

Purpose
To compare the safety and anti-cancer activity of Nanosomal Docetaxel Lipid Suspension (NDLS) to docetaxel (Taxotere®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV), triple negative (ER-, PR-, HER2-) breast cancer who have received no more than one chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nanosomal Docetaxel Lipid Suspension (NDLS), by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®) is a chemotherapy commonly used for breast cancer.</li> <li class="seamTextUnorderedListItem">Nanosomal Docetaxel Lipid Suspension (NDLS) is an experimental form of docetaxel. </li> <li class="seamTextUnorderedListItem">Research suggests that NDLS is safer than the standard form of docetaxel.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03671044' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/docetaxel-taxotere' target='_blank'>Breast Cancer Now: Docetaxel</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/nanosomal-docetaxel-lipid-suspension' target='_blank'>NCI Drug Dictionary: Nanosomal Docetaxel Lipid Suspension</a> </li><li class='seamTextUnorderedListItem'><a href='https://pubmed.ncbi.nlm.nih.gov/28255844/' target='_blank'>Journal Abstract: Nanosomal Docetaxel Lipid Suspension</a> </li></ul>
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276

NEAREST SITE: 1615 miles
Mayo Clinic Cancer Center
Rochester,MN

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02188745

Estrogen and an Aromatase Inhibitor in Advanced ER+ Breast Cancer

Phase II Pre-emptive OsciLLation of ER activitY Levels Through Alternation of Estradiol/Anti-estrogen Therapies Prior to Disease Progression in ER+/HER2- Advanced Breast Cancer Scientific Title

Purpose
To investigate how breast cancer responds when estrogen (17B-estradiol) is given along with an aromatase inhibitor--letrozole (Femara®), anastrozole (Arimidex®) or exemestane (Aromasin®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) breast cancer that is estrogen receptor positive and HER2 negative and for whom currently available therapy does not exist. You must have received at least one anti-estrogen therapy for for advanced/metastatic, but only one prior regimen of chemotherapy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive an alternating therapies of aromatase inhibitor (Femara®, Arimidex or Aromasin) and estrogen (17B-estradiol) by mouth, daily.</p>
  • <p class="seamTextPara"> Anti-estrogen therapies are used to treat ER+ tumors. However, over time, these tumors can stop responding to these treatments. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Laboratory studies suggest that giving a high dose of estrogen to patients whose tumors have stopped responding to an anti-estrogen therapy may get the tumor to respond again to the treatment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02188745' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02188745?term=NCT02188745&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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277

NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN

VISITS: 2-4 visits per month for 7 months

PHASE: II

NCT ID: NCT02876302

Jakafi and Chemo Before Surgery for Stage III Triple Negative Inflammatory Breast Cancer

Phase II Study Of Combination Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer Scientific Title

Purpose
To learn the safety and effects (good and bad) of using a new targeted drug along with chemotherapy to treat inflammatory breast cancer.
Who is this for?
People with stage III triple negative (ER-/PR-/HER2-), inflammatory breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups and receive the following before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly for 3 months </li> <li class="seamTextUnorderedListItem">followed by AC chemotherapy, by IV, every 2 weeks for 4 months </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly for 3 months </li> <li class="seamTextUnorderedListItem">Ruxolitinib (Jakafi®), by mouth, daily for 3 months </li> <li class="seamTextUnorderedListItem">followed by AC chemotherapy, by IV, every 2 weeks for 4 months </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly for 3 months </li> <li class="seamTextUnorderedListItem">Ruxolitinib (Jakafi®), by mouth, daily for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The targeted drug is ruxolitinib (Jakafi®). It is used to treat myelofibrosis, a disease of the bone marrow. </li> <li class="seamTextUnorderedListItem">Laboratory studies suggest Jakafi may make chemotherapy more effective. </li> <li class="seamTextUnorderedListItem">The chemotherapy drugs that will be used in this study are paclitaxel (Taxol®), doxorubicin (Adriamycin®) and cyclophosophamide (Cytoxan®).</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02876302' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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278

NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN

VISITS: Weekly study visits during radiation treatment

PHASE: NA

NCT ID: NCT02945579

Neoadjuvant Chemo & Radiation But No Surgery for Stage I-II Triple Negative or HER2 Positive Breast Cancer

Eliminating Breast Cancer Surgery in Exceptional Responders With Neoadjuvant Systemic Therapy Scientific Title

Purpose
To study the effects (good and bad) of avoiding surgery but still using radiation therapy in women whose biopsy shows their tumor disappeared after they received neoadjuvant chemotherapy.
Who is this for?
Women 40 or older with stage I or stage II triple negative (ER-, PR-, HER2-) or HER2 positive (HER2+) breast cancer. You must have already had chemotherapy to shrink your tumor, but no other treatments    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An image-guided biopsy (a biopsy that uses imaging such as CT, ultrasound, MRI or mammography)</li> <li class="seamTextUnorderedListItem">If the biopsy does not show any evidence of disease, you will then have radiation therapy</li> <li class="seamTextUnorderedListItem">If the biopsy show evidence of disease, you will have surgery then radiation therapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neoadjuvant chemotherapy (treatment given before surgery) is used to shrink tumors before surgery. The tumor may even disappear. When this occurs, researchers think it may be possible for patients to avoid surgery.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02945579' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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279

NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02993159

Tamoxifen Delivered Through the Breast Skin to Control ER+ DCIS Before Surgery

Phase IIB Trial of Neoadjuvant Oral Tamoxifen Versus Transdermal 4-hydroxytamoxifen in Women With DCIS of the Breast Scientific Title

Purpose
To compare the effect of tamoxifen (given orally) to an afimoxifene gel (applied to the breast before surgery) on the KI-67 protein.
Who is this for?
Women with ductal carcinoma in situ (DCIS) that is estrogen receptor positive (ER+). You must not have had surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Apply afimoxifene gel (TamoGel) to both breasts daily</li> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily, for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Apply placebo gel to both breasts daily</li> <li class="seamTextUnorderedListItem">Tamoxifen citrate (Nolvadex ®), by mouth, daily, for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by surgery</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Ki-67 protein increases as the cell prepares to divide into new cells. Afimoxifene gel (TamoGel) is a gel that is applied to the skin to relieve breast pain. </li> <li class="seamTextUnorderedListItem">Tamoxifen citrate (Nolvadex ®) is an anti-estrogen therapy used to treat hormone-sensitive breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02993159' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/diagnosis/rate_grade' target='_blank'>Breastcancer.org: Ki-67</a> </li></ul>
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280

NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN

VISITS: 1 visit every 2-3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03106415

Pembrolizumab and Binimetinib for Advanced Triple Negative or ER-Low, HER2 Negative Breast Cancer

Phase I/II Trial of Pembrolizumab in Combination With Binimetinib in Unresectable Locally Advanced or Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To study the safety and effectiveness of using an immunotherapy along with a targeted therapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER), HER2 negative (HER2-) breast cancer. You must have received no more than 3 prior therapies for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda ®), by IV, once every 2-3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Binimetinib (MEK162), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low, HER2- breast cancer.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">Keytruda® is currently approved to treat certain types cancers. </li> <li class="seamTextUnorderedListItem">Binimetinib (MEK162) is a type of targeted therapy called an MEK inhibitor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03106415' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Binimetinib' target='_blank'>Wikipedia: Binimetinib</a> </li></ul>
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281

NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN

VISITS: 1 visit every 2 weeks, for 2 months

PHASE: I-II

NCT ID: NCT03793829

HER2 Vaccine Before Surgery For HER2 Positive DCIS

A Phase IB Trial of Neoadjuvant Multi-epitope HER2 Peptide Vaccine in Patients With HER2-expressing DCIS (HER2Vaccine) Scientific Title

Purpose
To look at the safety and effects (good and bad) that a HER2 vaccine has on DCIS cells.
Who is this for?
Women with ductal carcinoma in situ (DCIS) who are scheduled to have breast cancer surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">H2NVAC vaccine, by injection, once every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">GM-CSF, by injection, once every 2 weeks, for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Periodic echocardiograms to monitor heart function</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The vaccine is designed to teach the immune system to go after cancer cells that express HER2.</li> <li class="seamTextUnorderedListItem">You will also receive GM-CSF to prevent neutropenia--a low white blood cell count that increases your risk for infection.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03793829' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-vaccine-being-tested-may-help-prevent-breast-cancer/' target='_blank'>Mayo Clinic Cancer Center: Vaccine being tested may help prevent breast cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://drsusanloveresearch.org/behind-the-hype-breast-cancer-vaccine/' target='_blank'>Dr. Susan Love Foundation: Behind the Hype: Breast Cancer Vaccine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/navigating-cancer-care/how-cancer-treated/immunotherapy-and-vaccines/what-are-cancer-vaccines' target='_blank'>Cancer.net: What are Cancer Vaccines?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/tests-procedures/echocardiogram/about/pac-20393856' target='_blank'>Mayo Clinic: Echocardiogram</a> </li></ul>
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282

NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN

VISITS: 1 visit per month, ongoing

PHASE: II

NCT ID: NCT03941730

Estradiol in Advanced Triple Negative & ER-Low Tumors that Test Positive for ER Beta

Therapeutic Targeting of ER Beta in Triple Negative Breast Cancer Scientific Title

Purpose
To study the effects (good and bad) of estradiol in the subset of triple negative and ER-Low tumors that test positive for ER beta.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer whose tumor tests positive for estrogen receptor beta (ER beta).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Estradiol, by mouth, 3 times a day</li> <li class="seamTextUnorderedListItem">2 biopsies (at the start of treatment and after 1 month)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Early studies suggest that estradiol--a type of estrogen--slows the growth of tumors that are ER-beta positive.</li> <li class="seamTextUnorderedListItem">Targets or mutations: ER beta</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03941730' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Estrogen_receptor_beta' target='_blank'>Wikipedia: Estrogen receptor beta</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.drugs.com/estradiol.html' target='_blank'>Drugs.com: Estradiol</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayo.edu/research/centers-programs/cancer-research/research-programs/womens-cancer-program/breast-cancer-spore/research-projects/therapeutic-targeting-estrogen-receptor-beta-triple-negative-breast-cancer' target='_blank'>Mayo Clinic: Therapeutic Targeting Estrogen receptor-beta in TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/30338035' target='_blank'>Journal Abstract: Estrogen receptor-beta is a potential target for TNBC</a> </li></ul>
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283

NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03979508

Abemaciclib Before Surgery for Women with Stage I-III, Triple Negative or ER-Low, HER2- Breast Cancer That Did Not Respond to Chemotherapy

Window Trial of Abemaciclib for Surgically Resectable, Chemotherapy-Resistant, Triple Negative Breast Cancer (a BEAUTY Study*) Scientific Title

Purpose
To study the safety and effects of using the CDK 4/6 inhibitor abemaciclib (Verzenio®) after neoadjuvant chemotherapy and before surgery.
Who is this for?
Women with stage I, stage II, or stage III triple negative (ER-, PR- HER2-) or ER-Low (1%-10% ER), HER2- breast cancer that did not fully respond to chemotherapy given before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, twice a day, for 2 to 3 weeks before your surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low, HER2- breast cancer.</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®) is a CDK 4/6 inhibitor approved to treat HR+ and HER2- metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">Its use in this trial is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03979508' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/cdk46-inhibitors' target='_blank'>Breastcancer.org: What Are CDK4/6 Inhibitors?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verzenio.com/?utm_source=google&utm_medium=ppc&campaign=6456675261&adgroup=82640243172&ad=378689406892&utm_keyword=kwd-389189556877&gclid=Cj0KCQiAmsrxBRDaARIsANyiD1qSisgRZtObbCNg3aCVnfoCwqXFjJlXYQsig6GLWR1OKy3oM7jjYJIaAtcqEALw_wcB' target='_blank'>Eli Lilly and Company Drug Information Page: Verzenio® (Abemaciclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org/' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2018/09/01/mbc-news-3/' target='_blank'>Metastatic Trial Talk: Insights Into Treatment Resistance</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523967/' target='_blank'>Journal Article: Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer</a> </li></ul>
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284

NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN

VISITS: Every 2 weeks, for 2 months

PHASE: I

NCT ID: NCT04144023

Vaccine Before Surgery for HER2-Expressing DCIS

A Phase IB Trial of Neoadjvuant Multi-Epitope HER2 Peptide Vaccine in Patients With HER2-Expressing DCIS Scientific Title

Purpose
To study the best dose, safety, and effects (good and bad) of a HER2 vaccine called H2NVAC.
Who is this for?
Women with DCIS that is HER2-expressing and who have not have had any other treatments for this DCIS.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HER2 vaccine H2NVAC, by injection, once every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">GM-CSF, by injection, once every 2 weeks for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedure</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving the H2NVAC vaccine before surgery allows researchers to study the effect that it has on cancer cells. </li> <li class="seamTextUnorderedListItem">Cancer vaccines are a type of immunotherapy. They are designed to teach the immune system to see and kill cancer cells.</li> <li class="seamTextUnorderedListItem">HER2-expressing DCIS will have an immunohistochemistry of +1, +2, or +3.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04144023' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/navigating-cancer-care/how-cancer-treated/immunotherapy-and-vaccines/what-are-cancer-vaccines' target='_blank'>ASCO Cancer.net: What are Cancer Vaccines?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayo.edu/research/forefront/researchers-testing-vaccine-against-dcis' target='_blank'>Mayo Clinic: Vaccine for DCIS</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youtube.com/watch?v=-gJfkmv5ZIs' target='_blank'>Dr. Susan Love Research Foundation: Breast Cancer Vaccines (Video)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearch.org/immunotherapy/treatment-types/cancer-vaccines' target='_blank'>Cancer Research Institute: Cancer Vaccines, Preventive, Therapeutic, Personalized</a> </li></ul>
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285

NEAREST SITE: 1621 miles
MD Anderson in The Woodlands
The Woodlands,TX

VISITS: Coincides with routine care

PHASE: NA

NCT ID: NCT00477100

Inflammatory Breast Cancer Registry

Inflammatory Breast Cancer (IBC) Registry Scientific Title

Purpose
To collect blood and tissue samples and clinical data.
Who is this for?
People with new clinical diagnosis of primary inflammatory breast cancer (IBC), second primary IBC, or highly suspicious for IBC.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will have the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Additional blood drawn during a routine blood draw</li> <li class="seamTextUnorderedListItem">Core, breast tissue, and skin biopsy (performed for diagnosis)</li> <li class="seamTextUnorderedListItem">Medical history interview</li> <li class="seamTextUnorderedListItem">Clinical data collected from your medical records</li> <li class="seamTextUnorderedListItem">Photographs of both breasts</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Inflammatory breast cancer is a rare, aggressive type of breast cancer in which the cancer cells block the lymph vessels in the skin, causing the breast to appear red and swollen. </li> <li class="seamTextUnorderedListItem">Researchers have not yet identified any genes or other risk factors that they could use to design better treatments for inflammatory breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00477100' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/factsheet/sites-types/ibc' target='_blank'>Cancer.gov: Inflammatory Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/types/inflammatory' target='_blank'>BreastCancer.org: IBC</a> </li><li class='seamTextUnorderedListItem'><a href='http://scholar.google.com/scholar?q=inflammatory+breast+cancer&hl=en&btnG=Search' target='_blank'>Google Scholar: IBC</a> </li></ul>
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286

NEAREST SITE: 1621 miles
MD Anderson in The Woodlands
Conroe,TX

VISITS: Daily visits for 2 to 2.5 weeks

PHASE: II

NCT ID: NCT03077841

Hypofractionated Radiation Therapy for DCIS or Early Stage Breast Cancer

Optimizing Preventative Adjuvant Linac-based Radiation: the OPAL Trial A Phase II Study of Hypofractionated Partial Breast Irradiation in Women With Early Stage Breast Cancer Scientific Title

Purpose
To evaluate the effects (good and bad) of hypofractionated radiation.
Who is this for?
Women 50 or older and recently diagnosed with DCIS or stage I or stage II breast cancer. If you have stage I or II breast cancer, your tumor must be estrogen receptor positive (ER+).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation treatment, 5 days a week for 2 to 2.5 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation treatment delivers larger doses of radiation in less time than standard radiation therapy.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03077841' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/shorter-radiation-better-for-early-stage' target='_blank'>Breastcancer.org: Shorter Radiation Course for Early Stage Breast Cancer</a> </li></ul>
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287

NEAREST SITE: 1625 miles
Houston Methodist Hospital Willowbrook
Houston,TX

VISITS: Number of visits unavailable, over 1 year

PHASE: II-III

NCT ID: NCT02068092

Effect of Olive Oil on Breast Density in High-Risk Women

A Pilot Study of Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention In Women At High Risk Of Breast Cancer Scientific Title

Purpose
To evaluate the effect that hydroxytyrosol has on the breast tissue of women who are at high risk for developing breast cancer.
Who is this for?
Women who are at high risk for developing breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Baseline mammogram within 90 days prior to start of the study</li> <li class="seamTextUnorderedListItem">Hydroxytyrosol by mouth daily for 1 year</li> <li class="seamTextUnorderedListItem">Core needle biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Studies have shown that women with dense breast tissue are at increased risk for developing breast cancer.</li> <li class="seamTextUnorderedListItem">Laboratory studies have found that hydroxytyrosol--a major component of olive oil--is a powerful antioxidant with very low toxicity in the human body, even at high doses. </li> <li class="seamTextUnorderedListItem">Researchers think that hydroxytyrosol may reduce dense breast tissue.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02068092' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.sciencedaily.com/releases/2014/01/140122112401.htm' target='_blank'>Science Daily: Study article</a> </li></ul>
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288

NEAREST SITE: 1643 miles
Houston Methodist Hospital
Houston,TX

VISITS: 5 visits a week, every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT02834403

L-NMMA plus Taxotere for Women with Advanced Triple Negative or ER-Low Breast Cancer

Clinical Phase Ib Trial of L-NMMA Plus Docetaxel in the Treatment of Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients Scientific Title

Purpose
To determine the best dose, safety and effects of L-NMMA when it is given with chemotherapy.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer. If you are stage III, you must have received at least 3 types of chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">L-NMMA, by IV, daily for 5 days, every 3 weeks</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV, once every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws</li> <li class="seamTextUnorderedListItem">Biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">L-NMMA targets the NOS (nitric oxide synthase) inhibitor.</li> <li class="seamTextUnorderedListItem">The chemotherapy being used is docetaxel (Taxotere®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02834403' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/77/13_Supplement/CT037' target='_blank'>AACR Abstract: L-NMMA</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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289

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02764541

Ibrance Before Surgery for HR-Positive Stage I-III Breast Cancer

Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS): A Randomized Phase II Study of Palbociclib With Letrozole Versus Letrozole Alone for Invasive Lobular Carcinoma and Invasive Ductal Carcinoma Scientific Title

Purpose
To look at the safety and effects (good and bad) of using the drug Ibrance along with a hormone therapy to treat breast cancer.
Who is this for?
Women with stage I, stage II or stage III hormone receptor positive (ER+ and/or PR+), HER2 negative breast cancer. Your tumor must be at least 1.5 cm in size.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy, by mouth daily over 2 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Part 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy, by mouth, daily over 6 months</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily over 6 months</li> </ul> <p class="seamTextPara"> OR </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy, by mouth, daily over 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">If you are premenopausal, you will enroll directly into part 2 of the study</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a targeted therapy that keeps cancer cells from growing by blocking two enzymes, CDK4 and CDK6.</li> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®) and letrozole (Femara®) are hormone therapies commonly used to treat hormone sensitive breast cancer.</li> <li class="seamTextUnorderedListItem">Giving drugs before surgery is called neoadjuvant therapy. It allows researchers to study the effect the drugs have on the tumor.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02764541' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02764541?term=NCT02764541&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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290

NEAREST SITE: 1643 miles
University of Texas MD Anderson Cancer Center/Regional Cancer Centers
Houston,TX

VISITS: 1 visit

PHASE: NA

NCT ID: NCT01772771

Testing Tumors to Personalize Cancer Therapy

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program Scientific Title

Purpose
To perform tests on a piece of your tumor to see what types of mutations it has and use these findings to recommend personalized anti-cancer therapy.
Who is this for?
People with breast cancer who are receiving care at MD Anderson Cancer Center in Houston TX.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will have your tumor tissue sample collected and tested.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cancer cells have genes that have changed (mutated). </li> <li class="seamTextUnorderedListItem">Scientists are developing cancer treatments that work best in tumors with specific changes (mutations). </li> <li class="seamTextUnorderedListItem">This study will help researchers learn more about tumor mutations. </li> <li class="seamTextUnorderedListItem">It will also allow them to let you know when a clinical trial opens that is testing new drugs for your type of tumor.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01772771' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT01772771?term=NCT01772771&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='https://pct.mdanderson.org/#/' target='_blank'>MD Anderson: Personalized Cancer Therapy</a> </li></ul>
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291

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Visits weekly

PHASE: II

NCT ID: NCT02530489

Atezolizumab & Abraxane for Triple Negative Stage I-III Breast Tumors

Triple-Negative First-Line Study: Neoadjuvant Trial of Nab-Paclitaxel and MPDL3280A, a Pdl-1 Inhibitor in Patients With Triple Negative Breast Cancer Scientific Title

Purpose
To look at the safety and effects (good and bad) of using atezolizumab (Tecentriq®) and nab-paclitaxel (Abraxane®) before surgery and then using atezolizumab after surgery.
Who is this for?
People with stage I, stage II, or stage III triple negative (ER-, PR-, HER2-) breast cancer who have not yet received anti-cancer treatment including surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Before surgery:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, weekly for 3 months</li> <li class="seamTextUnorderedListItem">MPDL3280A (atezolizumab), by IV, every 3 weeks for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">After surgery:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MPDL3280A, by IV, every 3 weeks for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is an immunotherapy drug that stimulates the body's immune system to go after cancer cells. It works by blocking a protein called programmed cell death ligand-1 (PD-L1) that normally keeps the body's immune system from attacking and destroying tumor cells. </li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®) is a chemotherapy drug routinely used to treat advanced breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02530489' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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292

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02152254

Molecular Profiling-Based Targeted Therapies for Metastatic Breast Cancer (Basket Study)

A Basket Study: Randomized Study Evaluating Molecular Profiling and Targeted Agents in Metastatic Cancer: Initiative for Molecular Profiling and Advanced Cancer Therapy (IMPACT 2) Scientific Title

Purpose
To study if choosing cancer treatment based on your tumor's molecular profile is more effective than the current standard of care.
Who is this for?
People with metastatic (stage IV) breast cancer who have been treated with standard of care therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will have their tumor biopsy undergo molecular profiling. Participants who have tumors with no molecular abnormality will receive an FDA-approved therapy. Participants with a molecular abnormality will then be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Targeted therapy based on molecular profiling</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Physican's choice standard of care</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Patients whose tumors progress will have the option of crossing over to the other treatment arm</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Molecular profiling of a tumor may identify genetic mutations or biomarkers that suggest the tumor is likely to respond to a currently available targeted therapy. </li> <li class="seamTextUnorderedListItem">It is not known if choosing metastatic breast cancer treatment based on the tumor's molecular profile is more effective than the current standard of care. </li> <li class="seamTextUnorderedListItem">All patients who enroll in this study will have molecular profiling performed on a biopsy of their tumor. </li> <li class="seamTextUnorderedListItem">If there is no mutation or biomarker found, the patient will receive the treatment their doctor determines is the best option. </li> <li class="seamTextUnorderedListItem">If a mutation or biomarker is found and there is an FDA-approved drug for the tumor type, patients will be offered that treatment. </li> <li class="seamTextUnorderedListItem">If there is a mutation or biomarker found but no FDA-approved drug that targets it, patients will be randomly assigned to either a targeted therapy or the standard of care.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: vary based on test results.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02152254' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825646/' target='_blank'>Journal Article: Molecular Profiling for Breast Cancer</a> </li></ul>
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293

NEAREST SITE: 1643 miles
University of Texas MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT00851032

Initiative for Molecular Profiling in Advanced Cancer Therapy (IMPACT) Trial

A Basket Study: An Initiative for Molecular Profiling in Advanced Cancer Therapy (IMPACT) Trial. A Molecular Profile-Based Study in Patients With Advanced Cancer Treated in the Investigational Cancer Therapeutics Program Scientific Title

Purpose
To see if there is an association between the tumor's molecular profile, how the tumor responds to drugs in phase I trials, and which side effects the patient experiences.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who are receiving care at the Investigational Cancer Therapeutics department at MD Anderson Cancer Center in Texas.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will have genetic profiling done on their blood and tissue samples stored at the MD Anderson Tissue Bank.</p>
  • <p class="seamTextPara"> Molecular profiling allows researchers to identify a tumor's specific mutations and biomarkers. </p>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00851032' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT00851032' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/education-and-research/departments-programs-and-labs/departments-and-divisions/investigational-cancer-therapeutics/research/personalized-cancer-therapy/index.html' target='_blank'>MD Anderson: Personalized Cancer Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/oncolog/january-2015/impact2-study-tests-benefits-of-personalized-cancer-treatment-ba.html' target='_blank'>MD Anderson: article</a> </li></ul>
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294

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Weekly visits for 3 months

PHASE: II

NCT ID: NCT02456857

Liposomal Doxorubicin, Bevacizumab and Temsirolimus For Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy

Women's Triple-Negative First-Line Study: A Phase II Trial of Liposomal Doxorubicin, Bevacizumab and Temsirolimus (DAT) in Patients With Localized Triple-Negative Breast Cancer (TNBC) With Tumors Predicted Insensitive to Standard Neoadjuvant Chemotherapy Scientific Title

Purpose
To study the effect that the DAT regimen has when it is given before surgery.
Who is this for?
Women with triple negative (ER-, PR-, HER2-) breast cancer who have stopped a neoadjuvant chemotherapy because the cancer progressed or they experienced too many side effects to continue.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following treatment before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DAT (Bevacizumab, Liposomal Doxorubicin and Temsirolimus), by IV for 6 hours, once every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Temsirolimus (Torisel®) alone, by IV for 90 minutes, weekly following each DAT treatment</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by surgery</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The experimental drug regimen DAT, consists of liposomal doxorubicin (Doxil®), bevacizumab (Avastin®), and temsirolimus (Torisel®). </li> <li class="seamTextUnorderedListItem">Doxil is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Avastin works by keeping the cancer from making the blood vessels it needs to grow. It currently is not approved as a breast cancer treatment. </li> <li class="seamTextUnorderedListItem">Torisel is an mTOR inhibitor. It works by blocking a protein called mTOR that helps cancer cells grow. </li> <li class="seamTextUnorderedListItem">Treatment given before surgery--called neoadjuvant therapy---allows researchers to see the effect that the treatment has on the tumor.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02456857' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02456857?term=NCT02456857&rank=1' target='_blank'>ClincialTrials.gov trial information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancerresearchuk.org/about-cancer/cancers-in-general/treatment/cancer-drugs/temsirolimus' target='_blank'>CancerResearchUK: Temsirolimus</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancerresearchuk.org/about-cancer/cancers-in-general/treatment/cancer-drugs/liposomal-doxorubicin' target='_blank'>CancerResearchUK: Liposomal doxorubicin</a> </li></ul>
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295

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit every 3 weeks, ongoing

PHASE: II

NCT ID: NCT02411656

Pembrolizumab for Metastatic HER2- Inflammatory, Triple Negative, and ER-Low Breast Cancer

A Phase II Study of Anti-PD-1 (MK-3475) Therapy in Patients With Metastatic Inflammatory Breast Cancer Who Have Received Prior Chemotherapy With Clinical Response Scientific Title

Purpose
To look at the safety and effects (good and bad) of using pembrolizumab (Keytruda®).
Who is this for?
People with metastatic (stage IV) HER2 negative inflammatory, triple negative (ER-, PR-, HER2-), or ER-Low (1%-10%) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is an immunotherapy that helps the body's immune system slow or stop cancer cell growth by blocking a protein known as programmed cell death receptor-1 (PD-1).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02411656' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=CjwKCAjwy7vlBRACEiwAZvdx9jIPFQgWidLA-C5wT1MzjtITa1lJzO4axMQhgd1rro0RP5g40-abvxoCQlYQA' target='_blank'>Merck Drug Information Page: Keytruda</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pembrolizumab' target='_blank'>NCI Drug Dictionary: Pembrolizumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/Inflammatory-Breast-Cancer.html' target='_blank'>Susan G. Komen: Inflammatory Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/TripleNegativeBreastCancer.html' target='_blank'>Susan G. Komen: Triple Negative Breast Cancer</a> </li></ul>
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296

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 2 visits per day, for 5 days

PHASE: II

NCT ID: NCT01245712

Proton Beam Partial Breast Radiation for Women With DCIS or Stage I-II Breast Cancer

Assessing the Cosmesis and Toxicity of Partial Breast Irradiation Using Proton Beam Irradiation Scientific Title

Purpose
To study if there are fewer or less severe side effects when using proton-beam PBI (Partial Breast Irradiation) therapy for 1 week instead of standard radiation therapy for 3 to 7 weeks.
Who is this for?
Women with DCIS or stage I or stage II breast cancer planning to have radiation therapy and a lumpectomy (or who have already had a lumpectomy).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Proton radiation therapy, two times per day, at least six hours apart, for five consecutive days</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DCIS and stage I-II breast cancer treated with a lumpectomy is often followed by radiation therapy, which is used to kill any cancer cells that may still remain in the breast.</li> <li class="seamTextUnorderedListItem">Radiation therapy is usually given five days a week, for up to seven weeks.</li> <li class="seamTextUnorderedListItem">Proton-beam partial breast irradiation (PBI) is a newer type of radiation therapy. It is given over a shorter time period, and it directs the radiation to the precise area of the breast where the cancer was removed so that less healthy tissue is affected.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01245712' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pennmedicine.org/for-health-care-professionals/for-physicians/physician-education-and-resources/clinical-briefings/2017/june/enrolling-clinical-trials-proton-radiotherapy-for-accelerated-partial-breast-irradiation-in-stage-0-i---ii-breast-canc' target='_blank'>Penn Medicine: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='hhttp://www.breastcancer.org/treatment/radiation/' target='_blank'>Breastcancer.org: Radiation</a> </li><li class='seamTextUnorderedListItem'><a href='http://scholar.google.com/scholar?q=Proton+Beam+Partial+Breast+Radiation&hl=en&btnG=Search&as_sdt=1%2C5&as_sdtp=on' target='_blank'>Google Scholar: proton beam PBI</a> </li></ul>
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297

NEAREST SITE: 1643 miles
The University of Texas MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02400476

Neratinib & Imodium after Herceptin for HER2+ Stage I-III Breast Cancer

A Study Looking the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and Loperamide Scientific Title

Purpose
To see whether women with HER2 positive tumors who take Imodium along with neratinib experience less diarrhea.
Who is this for?
Women with stage I, stage II, or stage III HER2 positive breast cancer who have previously received Herceptin.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib, by mouth, daily</li> <li class="seamTextUnorderedListItem">Loperamide, by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib is a targeted therapy that is currently being studied in clinical trials for HER2 positive breast cancer. </li> <li class="seamTextUnorderedListItem">These studies have found that diarrhea is one of the common side effects of neratinib. </li> <li class="seamTextUnorderedListItem">Loperamide (Imodium) is an over-the-counter medication used to prevent and treat diarrhea.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02400476' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.medscape.org/viewarticle/586897' target='_blank'>Medscape.org: Neratinib for HER2-positive Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.webmd.com/drugs/2/drug-4789-4025/loperamide-oral/loperamide-oral/details' target='_blank'>WebMD: Loperamide</a> </li></ul>
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298

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Weekly visits, ongoing

PHASE: I

NCT ID: NCT01552434

Bevacizumab & Temsirolimus with Valproic Acid or Cetuximab in Advanced Breast Cancer

A Phase I Trial of Bevacizumab, Temsirolimus Alone and in Combination With Valproic Acid, or Cetuximab in Patients With Advanced Malignancy and Other Indications Scientific Title

Purpose
To compare the effects (good and bad) of bevacizumab (Avastin®) and temsirolimus (Torisel®) alone or with valproic acid (Depakote®) or cetuximab (Erbitux®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer and have previously been treated with a standard therapy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Temsirolimus, by IV, once a week </li> <li class="seamTextUnorderedListItem">Bevacizumab, by IV, twice a month </li> <li class="seamTextUnorderedListItem">Cetuximab, by IV, once a week </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Temsirolimus, by IV, once a week </li> <li class="seamTextUnorderedListItem">Bevacizumab, by IV, twice a month </li> <li class="seamTextUnorderedListItem">Valproic acid, by mouth, daily on the first and third week of every month. </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Temsirolimus, by IV, once a week </li> <li class="seamTextUnorderedListItem">Bevacizumab, by IV, twice a month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Avastin is a targeted therapy that blocks the growth of the blood vessels that cancer cells need to survive. It is used to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Torisel is a type of targeted therapy called an mTOR inhibitor. It is approved to treat kidney cancer. </li> <li class="seamTextUnorderedListItem">Depakote is an anti-seizure medication that researchers think may also slow cancer cell growth. </li> <li class="seamTextUnorderedListItem">Erbitux is a type of targeted therapy called an EGFR inhibitor. It is approved to treat head, neck and colorectal cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01552434' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/patients/medicines/avastin' target='_blank'>Genetech: Avastin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncolink.org/cancer-treatment/oncolink-rx/temsirolimus-torisel-r' target='_blank'>Oncolink: Temsirolimus</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/cetuximab' target='_blank'>Cancer Research UK: Cetuximab</a> </li></ul>
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299

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02286687

Talazoparib for People With Advanced Breast Cancer Whose Tumor Tests Positive for a Tumor (Not Inherited) BRCA 1/2 Mutation

Phase II Study of the PARP Inhibitor BMN 673 (Talazoparib Tosylate) in Advanced Cancer Patients With Somatic Alterations in BRCA1/2, Mutations/Deletions in PTEN or PTEN Loss, a Homologous Recombination Defect, Mutations/Deletions in Other BRCA Pathway Genes and Germline Mutation in BRCA1/2 (Not Breast or Ovarian Cancer) Scientific Title

Purpose
To study the safety and anti-cancer activity of the PARP inhibitor talazoparib (Talzenna®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer whose tumor tests positive for a tumor (not inherited) BRCA mutation.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib® is a type of drug called a PARP inhibitor. It works by preventing the PARP protein from repairing damaged DNA in tumor cells.</li> <li class="seamTextUnorderedListItem">Targets or mutations: tumor (not inherited) BRCA 1 or BRCA 2 mutations</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02286687' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.talzenna.com/?source=google&HBX_PK=s_talazoparib&skwid=43700051780449266' target='_blank'>Pfizer Oncology Drug Information Page: Talzenna® (Talazoparib)</a> </li></ul>
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300

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Visits weekly over 3 months

PHASE: II

NCT ID: NCT02593175

Vectibix, Paraplatin & Taxol Before Surgery For Early Stage Triple Negative Breast Cancer

Women's Triple-Negative First-Line Study: A Phase II Trial of Panitumumab, Carboplatin and Paclitaxel (PaCT) in Patients With Localized Triple-Negative Breast Cancer (TNBC) With Tumors Predicted Insensitive to Standard Neoadjuvant Chemotherapy Scientific Title

Purpose
To see if giving three types of cancer drugs at the same time before surgery will shrink triple negative tumors.
Who is this for?
Women with stage I, stage II, or stage II triple-negative (ER-, PR-,HER2-) breast cancer but have not yet had surgery. You must also have a type of tumor that is not likely to get smaller with the standard type of chemotherapy usually given before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following over 3 months followed by surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Panitumumab (Vectibix®), by IV, weekly (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vectibix®, Paraplatin, and Taxol are three different types of cancer drugs. </li> <li class="seamTextUnorderedListItem">Panitumumab (Vectibix®) is a targeted therapy used to treat certain types of colorectal cancer. </li> <li class="seamTextUnorderedListItem">Its use in breast cancer is considered experimental. Experimental drugs can only be used through a clinical trial. </li> <li class="seamTextUnorderedListItem">Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific types of cancer cells only, doing less harm to normal cells. </li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) and paclitaxel (Taxol®) are chemotherapy drugs that are used to treat breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02593175' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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301

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Visits weekly for 3 months

PHASE: II

NCT ID: NCT02689427

Xtandi and Taxol Before Surgery for Stage I-III Triple Negative Breast Cancer that is Androgen Receptor Positive

A Phase IIB Study of Neoadjuvant Enzalutamide (ZT) Regimen Therapy in Combination With Weekly Paclitaxel for Androgen Receptor (AR)-Positive Triple-Negative Breast Cancer Scientific Title

Purpose
To look at the safety and anti-cancer activity of giving an anti-androgen drug along with chemotherapy before surgery.
Who is this for?
People with stage I, stage II or stage III triple negative (ER-, PR-, HER2-) breast cancer that is androgen receptor positive (AR+).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Enzalutamide (Xtandi®), by mouth, daily for 3 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Androgen receptors (AR) are found on many triple-negative breast tumors.</li> <li class="seamTextUnorderedListItem">Researchers think drugs that blocking these receptors could keep breast cancer cells from growing.</li> <li class="seamTextUnorderedListItem">The anti-androgen drug that will be used in this study is enzalutamide (Xtandi®). It is currently used to treat prostate cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: AR (androgen receptor)</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02689427' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/about-cancer/treatment/drugs/enzalutamide' target='_blank'>NCI Drug Drug Dictionary: Xtandi</a> </li></ul>
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302

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 10-12 visits over 8 weeks

PHASE: II

NCT ID: NCT02754752

Acupuncture for Relieving Severe Post-Mastectomy Pain

Randomized-Controlled Trial of Acupuncture for Post-Mastectomy Pain Syndrome Scientific Title

Purpose
This study is investigating whether electro-acupuncture can help reduce pain women feel after their mastectomy.
Who is this for?
Women who had a mastectomy at least 4 months ago. You must have had persistent pain in your chest area for at least 3 months and have seen your oncologist within the last 6 months.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Acupuncture on specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Acupuncture on non-specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Wait-List</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No acupuncture</li> <li class="seamTextUnorderedListItem">After 4 weeks, optional participation in up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Electro-acupuncture is a two-step process. First, hair-thin needles are put into specific points in your body. Then, a mild electrical current is applied to the needles at a level that is comfortable to you.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02754752' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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303

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Visits every 1-3 weeks over 6 months

PHASE: II

NCT ID: NCT02876107

Vectibix and Chemotherapy Before Surgery for Triple Negative Inflammatory Breast Cancer

A Randomized Phase II Study of Neoadjuvant Carboplatin/Paclitaxel (CT) Versus Panitumumab/Carboplatin/Paclitaxel (PaCT) Followed by Anthracycline-Containing Regimen for Newly Diagnosed Primary Triple-Negative Inflammatory Breast Cancer Scientific Title

Purpose
To see if chemotherapy combinations used to treat advanced breast cancer are more effective when given along with a targeted drug. The treatments are given before you have surgery.
Who is this for?
Women who are newly diagnosed with stage III, inflammatory triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Chemo with Vectibix for 3 months</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Panitumumab (Vectibix®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Chemo without Vectibix for 3 months</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AC (Adriamycin® and Cytoxan®), by IV, every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">followed by surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The initial chemotherapy combination is carboplatin (Paraplatin®) and paclitaxel (Taxol®). </li> <li class="seamTextUnorderedListItem">It is followed by doxorubicin (Adriamycin®) and cyclophosphamide (Cytoxan®)--known as AC. </li> <li class="seamTextUnorderedListItem">The targeted drug is panitumumab (Vectibix®).</li> <li class="seamTextUnorderedListItem">Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific types of cancer cells only, doing less harm to normal cells. </li> <li class="seamTextUnorderedListItem">Vectibix® is currently used to treat a certain type of metastatic colorectal cancer. </li> <li class="seamTextUnorderedListItem">It is not yet known if Vectibix® will be effective as a treatment for breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02876107' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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304

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 5 visits per week for 3 or 5 weeks

PHASE: II

NCT ID: NCT02912312

The Risk of Developing Lymphedema When Using Hypofractionated Radiation For DCIS & Stage I-III Breast Cancer

Shortening Adjuvant Photon Irradiation to Reduce Edema (SAPHIRE): A Randomized Trial of Hypofractionated Versus Conventionally Fractionated Regional Nodal Irradiation for Invasive Breast Cancer Scientific Title

Purpose
To compare the effects (good and bad) and the risk of developing lymphedema when using hypofractionated radiation therapy of the lymph nodes to traditional radiation therapy of the lymph nodes.
Who is this for?
Women with DCIS or stage I, stage II, or stage III breast cancer. You must have had surgery as part of your treatment unless you had DCIS.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Shorter radiation schedule (hypofractionated)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">15 radiation treatments: 5 days a week, for 3 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires, blood draws, and arm measurements, 7 visits over 10.5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard radiation</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">25 radiation treatments: 5 days a week, for 5 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires, blood draws, and arm measurements, 7 visits over 10.5 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that develops as a side effect of breast cancer treatments like surgery and radiation therapy. </li> <li class="seamTextUnorderedListItem">Giving the traditional amount of radiation in a shorter period of time is called hypofractionated whole-breast radiation.</li> <li class="seamTextUnorderedListItem">The hypofractionated radiation therapy used in this trial takes about 4 weeks.</li> <li class="seamTextUnorderedListItem">The tradiational radiation therapy used in this trial takes about 6 weeks.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02912312' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/lymphedema/how/treat_impact' target='_blank'>Breastcancer.org: Impact of Radiation Therapy on Lymphedema Risk</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/shorter-radiation-better-for-early-stage' target='_blank'>Breastcancer.org: Shorter Radiation for Early Stage Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li></ul>
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305

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit

PHASE: NA

NCT ID: NCT02918474

A Tool to Help Women Decide Whether to Have a Contralateral Preventative Mastectomy

Decision Making Tool for Contralateral Prophylactic Mastectomy Scientific Title

Purpose
To learn more about an online decision support tool that helps you and your doctor discuss whether or not you should have a contralateral prophylactic mastectomy (removal of breast that does not have cancer).
Who is this for?
Women recently diagnosed with DCIS or stage I, stage II, or stage III breast cancer and are seeing a surgeon at MD Anderson Cancer Center.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will complete a questionnaire before and after using the decision support tool.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">If you take part in this study, you will complete a questionnaire about the decision support tool.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02918474' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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306

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT02926690

OTS167PO: A Targeted Therapy for Advanced Triple Negative or ER-Low Breast Cancer

A Phase I Study of OTS167PO, a MELK Inhibitor, to Evaluate Safety, Tolerability and Pharmacokinetics in Patients With Advanced Breast Cancer and Dose-Expansion Study in Patients With Triple Negative Breast Cancer Scientific Title

Purpose
To determine the safety and effects (good and bad) of using the experimental targeted therapy OTS167PO.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast (ER-, PR-, HER2-) or ER-Low (1%-10%) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">OTS167PO </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">The targeted therapy used in this trial is OTS167PO. It is a MELK inhibitor. </li> <li class="seamTextUnorderedListItem">It is an experimental therapy. This means it is only available in clinical trials. </li> <li class="seamTextUnorderedListItem">Targets or mutations: MELK</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02926690' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncotherapy.co.jp/en/research-development/drug-discovery-research/melk-inhibitor/' target='_blank'>Drug Company Information Page: OTS167</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/melk-inhibitor-ots167' target='_blank'>NCI Drug Dictionary: OTS167</a> </li></ul>
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307

NEAREST SITE: 1643 miles
The Methodist Hospital System
Houston,TX

VISITS: Visits weekly or every 2 weeks for 6 months

PHASE: II

NCT ID: NCT02957968

Keytruda & Decitabine Then Neoadjuvant Chemotherapy in Advanced HER2 Negative Breast Cancer

T-Cell Immune Checkpoint Inhibition Plus Hypomethylation for Locally Advanced HER2-Negative Breast Cancer - A Phase 2 Neoadjuvant Window Trial of Pembrolizumab and Decitabine Followed by Standard Neoadjuvant Chemotherapy Scientific Title

Purpose
To study the safety and effects (good and bad) of giving immunotherapy and an experimental chemotherapy before giving standard of care neoadjuvant chemotherapy.
Who is this for?
People with locally advanced (some stage III) HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Triple Negative</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Decitabine and pembrolizumab (Keytruda®), scheduled determined by your doctor</li> <li class="seamTextUnorderedListItem">followed by AC (Adriamycin®/Cytoxan®), by IV, once every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">followed by paclitaxel and carboplatin, by IV, weekly, for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: HER2 negative, hormone positive</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Decitabine and pembrolizumab (Keytruda®), schedule determined by your doctor</li> <li class="seamTextUnorderedListItem">followed by AC (Adriamycin®/Cytoxan®), by IV, once every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">followed by paclitaxel, by IV, weekly, for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving therapies before surgery is called neoadjuvant treatment. This can shrink your tumor and allow researchers to study the effects the treatment had on your cancer cells. </li> <li class="seamTextUnorderedListItem">The immunotherapy used in this study is pembrolizumab (Keytruda®). It is approved to treat certain types of cancer but its use in this trial is considered experimental. </li> <li class="seamTextUnorderedListItem">Keytruda will be given along with the chemotherapy drug decitabine (Dacogen®), which is used to treat a certain type of blood cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02957968' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/decitabine' target='_blank'>Cancer Research UK: Decitabine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=Cj0KCQjw-_j1BRDkARIsAJcfmTFCLLDlVuNOgPVdOcuETY7kLiCJ-6rlJU8KGMwPhBxXJjp_oGSLJ1waAg-0E' target='_blank'>Merck Oncology Information Page: Keytruda® (Pembrolizumab)</a> </li></ul>
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308

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Visits once every 3 weeks, ongoing

PHASE: II

NCT ID: NCT02971748

Keytruda + an Anti-Estrogen Drug for HR+ Inflammatory Breast Cancer

A Phase II Study of Anti-PD-1 (Pembrolizumab) in Combination With Hormonal Therapy in Patients With Hormone Receptor (HR)-Positive Localized Inflammatory Breast Cancer (IBC) Who Did Not Achieve a Pathological Complete Response (pCR) to Neoadjuvant Chemotherapy Scientific Title

Purpose
To study the effects (good and bad) of treating inflammatory breast cancer with an immunotherapy drug along with a standard anti-estrogen drug.
Who is this for?
People with hormone receptor positive (ER+ and/or PR+) inflammatory breast cancer. You must have received chemotherapy prior to breast surgery, but tumor cells were still present after therapy was completed.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following for up to 2 years: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks</li> <li class="seamTextUnorderedListItem">Physician's choice hormone therapy (tamoxifen/Nolvadex®, exemestane/Aromasin®, anastorzole/Arimidex®, letrozole/Femara®, LHRH agonist), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy drug (treatment that uses your body's own immune system to help fight cancer) being used in this study is pembrolizumab (Keytruda®). </li> <li class="seamTextUnorderedListItem">Your doctor will choose which anti-estrogen drug you receive: tamoxifen/Nolvadex®, exemestane/Aromasin®, anastrozole/Arimidex®, or letrozole/Femara®. </li> <li class="seamTextUnorderedListItem">If you are premenopausal, you may also receive a therapy that will stop your ovaries from producing estrogen. </li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02971748' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/cancer-types/inflammatory-breast-cancer.html' target='_blank'>MD Anderson Inflammatory Breast Cancer Clinic</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/types/inflammatory' target='_blank'>Inflammatory Breast Cancer</a> </li></ul>
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309

NEAREST SITE: 1643 miles
Houston Methodist Cancer Center
Houston,TX

VISITS: 1 visit daily for 2 weeks, then every 3 weeks ongoing

PHASE: II

NCT ID: NCT03004183

Vaccine & Radiation Therapy Then Immunotherapy For Advanced Triple Negative Breast Cancer

Phase II Window of Opportunity Trial of Stereotactic Body Radiation Therapy and In Situ Oncolytic Virus Therapy in Metastatic Triple Negative Breast Cancer and Metastatic Non-Small Cell Lung Cancer Followed by Pembrolizumab (STOMP) Scientific Title

Purpose
To investigate the safety and effects (good and bad) of receiving a vaccine, then SBRT radiation therapy (stereotactic body radiation therapy), then the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have no other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ADV/HSV-tk, by injection, once</li> <li class="seamTextUnorderedListItem">followed by valacyclovir (anti-viral drug), by mouth, daily, for 2 weeks</li> <li class="seamTextUnorderedListItem">Stereotactic body radiation therapy (SBRT), 5 sessions over 2 weeks</li> <li class="seamTextUnorderedListItem">followed by pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The vaccine is called ADV/HSV-tk. It is given along with the anti-viral drug valacyclovir. </li> <li class="seamTextUnorderedListItem">The immunotherapy used in this study is pembrolizumab (Keytruda®). It is approved to treat certain types of cancers. </li> <li class="seamTextUnorderedListItem">This study is also enrolling people with advanced non-small cell lung cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03004183' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/aglatimagene-besadenovec' target='_blank'>NCI Drug Dictionary: ADV/HSV-tk</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/valacyclovir-hydrochloride' target='_blank'>NCI Drug Dictionary: Valacyclovir</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/treatment-options/stereotactic-body-radiation-therapy.html' target='_blank'>MD Anderson Cancer Center: SBRT</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nejm.org/doi/full/10.1056/NEJMoa1910549' target='_blank'>New England Journal of Medicine: Pembrolizumab for Early Triple-Negative Breast Cancer</a> </li></ul>
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310

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit

PHASE: NA

NCT ID: NCT03012399

Effects of Hypnosis During Breast Cancer Surgery

Biobehavioral Effects of Hypnosis During Breast Cancer Surgery Scientific Title

Purpose
To study a relaxation method called hypnosedation.
Who is this for?
Women with DCIS or stage I breast cancer who have not yet had breast surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnosedation performed by a hypnotherapist, beginning right before surgery and continuing through until your surgery ends</li> <li class="seamTextUnorderedListItem">Conscious sedation during surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Empathetic conversation with a hypnotherapist right before surgery</li> <li class="seamTextUnorderedListItem">General anesthesia during surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Using hypnosedation before and during breast cancer surgery may allow patients to avoid having general anesthesia.</li> <li class="seamTextUnorderedListItem">Hypnosedation is administered by a hypnotherapist, a mind-body specialist who uses words and images to help you relax during surgery.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03012399' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://abcnews.go.com/Health/Healthday/story?id=4508455&page=1' target='_blank'>ABC News: Hypnosis Article</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/comp_med/types/hypnosis' target='_blank'>Breastcancer.org: Hypnosis</a> </li></ul>
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311

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Weekly visits

PHASE: I-II

NCT ID: NCT03101748

Adding Neratinib to Treatment Regimens for Advanced or Inflammatory Breast Cancer

A Phase 1b Study of Neratinib, Pertuzumab and Trastuzumab With Taxol (3HT) in Primary Metastatic and Locally Advanced Breast Cancer, and Phase II Study of 3HT Followed by AC in HER2 + Primary IBC, and Neratinib With Taxol (NT) Followed by AC in HR+ /HER2- Primary IBC Scientific Title

Purpose
To investigate the safety and best dose of neratinib (Nerlynx®) to add to drug regimens used to treat advanced breast cancer.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) breast cancer that is HER2-positive. If you have inflammatory breast cancer, your tumor can be either HER2 positive (HER2+) or HER2 negative (HER2-) so long as its also estrogen receptor positive (ER+).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: HER2 Positive</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Keep a medication diary about neratinib</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: HER2 Positive Inflammatory</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, monthly</li> <li class="seamTextUnorderedListItem">Doxorubicin and cyclophosphamide, by IV, monthly</li> <li class="seamTextUnorderedListItem">followed by surgery</li> <li class="seamTextUnorderedListItem">Keep a medication diary about neratinib</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: HER2 Negative/ER Positive Inflammatory</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Doxorubicin and cyclophosphamide, by IV, monthly</li> <li class="seamTextUnorderedListItem">followed by surgery</li> <li class="seamTextUnorderedListItem">Keep a medication diary about neratinib</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®) is a tyrosine kinase inhibitor approved for use in patients with HER2 positive (HER2+) breast cancer</li> <li class="seamTextUnorderedListItem">The HER2-targeted drugs used in this study are pertuzumab (Perjeta®) and Herceptin. </li> <li class="seamTextUnorderedListItem">The chemotherapy drugs used in this study are doxorubicin/Adriamicin® and cyclophosphamide/Cytoxan®. </li> <li class="seamTextUnorderedListItem">Your treatment regimen will be determined by whether your tumor is HER2+ or HER2- and if you have inflammatory breast cancer. </li> <li class="seamTextUnorderedListItem">Women with inflammatory breast cancer will also have surgery.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03101748' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/inside-oncology/adam-brufsky-md/neratinib-for-metastatic-breast-cancer' target='_blank'>OncLive: Neratinib for Metastatic Breast Cancer (Video)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/neratinib-improves-pfs-in-her2-metastatic-breast-cancer' target='_blank'>OncLive: Neratinib Improves PFS in HER2+ MBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancer-news.com/pb272-neratinib/' target='_blank'>Breast Cancer News: Neratinib</a> </li></ul>
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312

NEAREST SITE: 1643 miles
University of Texas MD Anderson Cancer Center
Houston,TX

VISITS: 6 visits over the first 2 months; monthly visits thereafter

PHASE: I

NCT ID: NCT03162627

Selumetinib and Lynparza for Advanced Breast Cancer

Evaluation of the Combination of Selumetinib and Olaparib in Endometrial, Ovarian and Other Solid Tumors With Ras Pathway Alterations, and Ovarian Tumors With PARP Resistance Scientific Title

Purpose
To study the safety and anti-cancer activity of using the drug selumetinib along with olaparib (Lynparza®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer for whom available therapies are no longer effective.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Selumetinib (AZD6244), by mouth, daily, ongoing </li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Selumetinib (AZD6244) is an experimental targeted drug called an MEK inhibitor.</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of targeted drug called a PARP inhibitor. It is approved to treat certain types of ovarian cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03162627' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Selumetinib' target='_blank'>Wikipedia: Selumetinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparza.com' target='_blank'>AstraZeneca Information Page: Lynparza</a> </li></ul>
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313

NEAREST SITE: 1643 miles
The University of Texas MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03195699

Oral TTI-101 in Patients with Advanced Breast Cancer

Phase I Study of TTI-101, an Oral Inhibitor of Signal Transducer and Activator of Transcription (STAT) 3, in Patients With Advanced Cancers Scientific Title

Purpose
To study the safety, effects (good and bad), and best dose of TT1-101, a new oral cancer drug.
Who is this for?
People with locally advanced (stage III) or metastatic (stage IV) breast cancer and no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TTI-101 by mouth, for up to 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TTI-101 is a tyrosine-kinase inhibitor that blocks STAT3, a protein that helps cancer cells grow. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03195699' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/796468' target='_blank'>NCI Dictionary: TTI-101</a> </li></ul>
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314

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit every week to 2 weeks, ongoing

PHASE: II

NCT ID: NCT03202316

Tecentriq, Cotellic & Halaven for Metastatic Inflammatory Breast Cancer

A Phase II Study of Triple Combination of Atezolizumab + Cobimetinib + Eribulin (ACE) in Patients With Chemotherapy Resistant Metastatic Inflammatory Breast Cancer Scientific Title

Purpose
To determine the safety and effects (good and bad) of a combination therapy including chemotherapy, immunotherapy, and targeted therapies.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) inflammatory breast cancer. If your cancer is HER2 positive (HER2+), you must have received at least two anti-HER2 therapies, including pertuzumab (Perjeta®) and T-DM1 (Kadcyla®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">First 2 weeks</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, once</li> <li class="seamTextUnorderedListItem">Cobimetinib (Cotellic®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Eribulin (Halaven®), by IV, 8 times over 3.5 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 2 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Cobimetinib (Cotellic®), mouth, weekly (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is a type of immunotherapy called a PD-L1 inhibitor. </li> <li class="seamTextUnorderedListItem">FDA has approved Tecentriq® to treat certain types of bladder and lung cancer. </li> <li class="seamTextUnorderedListItem">Cobimetinib (Cotellic®) is a new targeted therapy called an MEK inhibitor. It is approved to treat certain types of melanoma. </li> <li class="seamTextUnorderedListItem">Eribulin (Halaven®) is a chemotherapy drug approved for treating metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03202316' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tecentriq.com' target='_blank'>Genentech Information Page: Tecentriq</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Cobimetinib' target='_blank'>Wikipedia: Cobimetinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cotellic.com' target='_blank'>Genentech Information Page: Cotellic</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.halaven.com/metastatic-breast-cancer' target='_blank'>Drug Company Information Page: Halaven</a> </li></ul>
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315

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03207529

Alpelisib & Enzalutamide in Advanced HER2 Negative Breast Cancer That Tests Positive for AR and PTEN

Phase Ib Study of BYL719 (Alpelisib) in Combination With Androgen Receptor Inhibitor (Enzalutamide) in Patients With Androgen Receptor (AR)-Positive and PTEN Positive Metastatic Breast Cancer Scientific Title

Purpose
To determine the best dose, safety, and effects (good and bad) of alpelisib (Piqray®) when it is used along with enzalutamide (Xtandi®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer that tests AR-positive and PTEN-positive and who have received at least one standard therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Enzalutamide (Xtandi®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Piqray is a targeted therapy that inhibits PI3K. It is approved to treat advanced hormone receptor positive, HER2 negative breast cancer in patients with a tumor that has a PIK3CA mutation. </li> <li class="seamTextUnorderedListItem">Xtandi is an oral drug that targets the androgen receptor (AR). It is approved to treat advanced prostate cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: AR (androgen receptor), PTEN</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03207529' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hcp.novartis.com/products/piqray/metastatic-breast-cancer/?site=PIQ-1221443GK100070&source=01030&gclid=CjwKCAjwqML6BRAHEiwAdquMndS0YjjO837gyodgP7mwwUOT5tESFIWm4OnegRTdcPJWR25nfOu0ohoCTgAQAvD_BwE&gclsrc=aw.ds' target='_blank'>Novartis Drug Information Page: Piqray® (Alpelisib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/enzalutamide' target='_blank'>NCI Drug Dictionary: Enzalutamide</a> </li></ul>
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316

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Monthly visits, ongoing

PHASE: I

NCT ID: NCT03218826

AZD8186 and Docetaxel for Advanced Breast Cancer with PTEN or PIK3C-beta Mutations

A Phase I Study of AZD8186 in Combination With Docetaxel in Patients With PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to Docetaxel Scientific Title

Purpose
To determine the best dose and effects (good and bad) of the targeted therapy AZD8186 when it is used with chemotherapy in tumors that test positive for PTEN or PIK3C-beta mutations.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that will potentially respond to the chemotherapy drug docetaxel (Taxotere®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD8186, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV, monthly, ongoing</li> <li class="seamTextUnorderedListItem">2 biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD8186 is an experimental targeted therapy that works by inhibiting PI3K proteins and is designed for cancers that are characterized as being deficient in PTEN.</li> <li class="seamTextUnorderedListItem">Taxotere is a chemotherapy commonly used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancers.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PTEN or PIK3CB</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03218826' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/risk/factors/genetics' target='_blank'>Breastcancer.org: Genetics</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pi3kbeta-inhibitor-azd8186' target='_blank'>NCI Dictionary: AZD8186</a> </li></ul>
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317

NEAREST SITE: 1643 miles
Baylor College of Medicine
Houston,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03324425

Simvastatin With Anti-HER2 Therapy in Patients With HER2-Positive Metastatic Breast Cancer

A Phase II Single Arm Trial of Adding Simvastatin to Dual Anti-HER2 Therapy in Patients With HER2-Positive Metastatic Breast Cancer (SIMPHONY) Scientific Title

Purpose
To look at the effects of using simvastatin (Zocor®) along with dual anti-HER2 therapy.
Who is this for?
Women with metastatic (stage IV) HER2 positive breast cancer that is being treated with two types of anti-HER2 therapies, but has stopped responding.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Simvastatin (Zocor®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Anti-HER2 therapy as determined by your physician</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Zocor is a drug that is approved to treat high cholesterol. </li> <li class="seamTextUnorderedListItem">Laboratory studies suggest that it can get tumors to start responding again to HER2-targeted therapies. </li> <li class="seamTextUnorderedListItem">The two HER2-targeted therapies you will be on in this study are those your doctor selected for you.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03324425' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a692030.html' target='_blank'>MedlinePlus: Simvastatin</a> </li></ul>
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318

NEAREST SITE: 1643 miles
University of Texas MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03429907

A Stress-Reduction Program for Women Getting Chemo Before Breast Cancer Surgery

An Early Stress-Reduction Intervention in Patients With Newly Diagnosed Breast Cancer: A Randomized Pilot Study Scientific Title

Purpose
To see whether patients who use a mind-body stress-reduction app for two weeks before starting neoadjuvant chemotherapy have lower stress, better mood, and fewer physical symptoms during treatment than patients who do not take part in this program.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who will have chemotherapy before surgery (neoadjuvant treatment) at MD Anderson Cancer Center in Texas.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mind-body exercises using an app, daily for 2 weeks before starting chemotherapy</li> <li class="seamTextUnorderedListItem">4 questionnaires, before, during and after chemotherapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">4 questionnaires, before, during and after chemotherapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The exercises are presented on an online application (<q>app</q>) on your personal electronic device.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03429907' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/tips/exercise/treatment/chemo_targeted' target='_blank'>Breastcancer.org: Exercise During and After Chemotherapy or Targeted Therapies</a> </li></ul>
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319

NEAREST SITE: 1643 miles
University of Texas MD Anderson Cancer Center
Houston,TX

VISITS: Hospital stay for 1 week; 4 visits in the first month; then 1 visit every 3 weeks for up to 1 year

PHASE: I

NCT ID: NCT03435952

Keytruda plus Bacterial Therapy for Advanced Breast (and Other) Tumors

A Phase Ib Investigation of Pembrolizumab in Combination With Intratumoral Injection of Clostridium Novyi-NT in Patients With Treatment-Refractory Solid Tumors Scientific Title

Purpose
To study the safety, effects (good and bad) and best dose of a type of bacteria that researchers believe will prime tumors to respond to an immunotherapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bacterial therapy (Clostridium Novyi-NT), by injection, once, on Day 8, during 1-week hospital stay</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, for up to 1 year</li> <li class="seamTextUnorderedListItem">Doxocyclin, by mouth, 2 times a day for the rest of your life to lower the risk of further growth of Clostridium novyi-NT</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The bacteria have been modified to remove the chemicals that are poisonous to humans. </li> <li class="seamTextUnorderedListItem">The bacterial therapy being used in this study is clostridium novyi-NT. </li> <li class="seamTextUnorderedListItem">The immunotherapy being used in this study is the PD-1 inhibitor pembrolizumab (Keytruda®). </li> <li class="seamTextUnorderedListItem">Keytruda stimulates the body's immune system to go after cancer cells. It is approved to treat select types of cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">You will also receive the antibiotic, doxocyclin. It is given to help keep the growth of the bacteria clostridium novyi-NT under control.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03435952' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/clostridium-novyi-nt-spores' target='_blank'>NCI Drug Dictionary: Clostridium novyi-NT</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedirect.com/science/article/pii/S2352304216000064' target='_blank'>Genes & Diseases: Clostridium novyi-NT in Cancer Therapy</a> </li></ul>
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320

NEAREST SITE: 1643 miles
University of Texas MD Anderson Cancer Center
Houston,TX

VISITS: 1 visit every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03501979

Tucatinib, Trastuzumab, and Capecitabine for HER2+ Breast Cancer with Leptomeningeal Metastases

A Phase II Non-randomized Study to Assess the Safety and Efficacy of the Combination of Tucatinib and Trastuzumab and Capecitabine for Treatment of Leptomeningeal Metastases in HER2 Positive Breast Cancer Scientific Title

Purpose
To look at the safety and effects (good and bad) of using tucatinib (Tukysa) along with trastuzumab (Herceptin®) and capecitabine (Xeloda®).
Who is this for?
People with metastatic (stage IV) HER2 positive (HER2+) breast cancer with leptomeningeal metastases. This is when the cancer spreads to the membranes lining the brain and spinal cord.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa), by mouth, twice daily</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks </li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, twice daily, 2 weeks on and 1 week off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa) is a HER2-targeted therapy approved to treat some advanced HER2+ breast cancer in combination with certain other therapies. </li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) is a commonly used HER2-targeted therapy. </li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®) is a type of chemotherapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03501979' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/herceptin' target='_blank'>Breastcancer.org: Trastuzumab (Herceptin®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/capecitabine' target='_blank'>CancerResearchUK: Capecitabine (Xeloda®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tukysahcp.com' target='_blank'>Seattle Genetics Information Page: Tukysa (Tucatinib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/publications/oncology-live/2018/vol-19-no-24/tucatinib-shows-promise-in-patients-with-breast-cancer-and-brain-metastases' target='_blank'>OncLive: Tucatinib Shows Promise in Patients With Breast Cancer and Brain Metastases</a> </li></ul>
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321

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit every 2 weeks, and 5 to 10 days of radiation therapy

PHASE: I

NCT ID: NCT03524170

Immunotherapy and Radiation Therapy for Metastatic Hormone Positive, HER2 Negative Breast Cancer

RACHEL1: A Phase I Radiation and CHEckpoint bLockade Trial in Patients With Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer Scientific Title

Purpose
To study the best dose, safety, and effects (good and bad) of using the immunotherapy M7824 in combination with radiation therapy.
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer. You must have at least two sites of metastatic disease as seen by imaging.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">M7824, by IV, every 2 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Radiation therapy, daily, 5-10 days</li> <li class="seamTextUnorderedListItem">Biopsy after 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">M7824 (MSB0011359C) is a protein with two components: PD-L1 antibody and TGF-β receptor. </li> <li class="seamTextUnorderedListItem">M7824 is currently being used for research purposes only.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03524170' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://stm.sciencemag.org/content/10/424/eaan5488' target='_blank'>Science Translational Medicine: M7824</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/oncolog/radiation-may-enhance-immunotherapy-for-solid-tumors.h10-1591413.html' target='_blank'>MD Anderson Cancer Center: Radiation May Enhance Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976948/' target='_blank'>Journal Article: Evolution of Radiation Therapy in MBC</a> </li></ul>
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322

NEAREST SITE: 1643 miles
Novartis Investigative Site
Houston,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03549000

NZV930, PDR001 and NIR178 Immunotherapies in Advanced Triple Negative Breast Cancer

A Phase I/Ib, Open-label, Multi-center, Study of NZV930 as a Single Agent and in Combination With PDR001 and/or NIR178 in Patients With Advanced Malignancies. Scientific Title

Purpose
To compare the safety and effects (good and bad) of NZV930 alone or in combination with PDR001 and/or NIR178.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) that has not responded to other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NZV930, by IV </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NZV930, by IV </li> <li class="seamTextUnorderedListItem">PDR001, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NZV930, by IV</li> <li class="seamTextUnorderedListItem">NIR178, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NZV930, by IV</li> <li class="seamTextUnorderedListItem">PDR001, by IV</li> <li class="seamTextUnorderedListItem">NIR178, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 biopsies (a new tumor biopsy at screening and during treatment)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NZV930 is an investigational targeted therapy that blocks the CD73 protein. Blocking this protein allows T cells and other immune cells to attack the tumor. </li> <li class="seamTextUnorderedListItem">PDR001 is an investigational immunotherapy. It is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">NIR178 is an investigational immunotherapy. It is an immune checkpoint inhibitor that gets the immune system to attack cancer cells by blocking the adenosine A2A receptor (A2AR).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03549000' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.surfaceoncology.com/our-science/srf373-nzv930-cd73-antibody/' target='_blank'>Sponsor site: AZV930</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/spartalizumab' target='_blank'>NCI Drug Dictionary: PDR001</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793151' target='_blank'>NCI Drug Dictionary: NIR178</a> </li></ul>
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323

NEAREST SITE: 1643 miles
UT M.D Anderson Cancer Center
Houston,TX

VISITS: Visits every 2 weeks, ongoing

PHASE: I-II

NCT ID: NCT03576131

GEN1029 for Advanced Breast (and Other) Cancer

First-in-human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety of GEN1029 in Patients With Malignant Solid Tumors Scientific Title

Purpose
To determine the best dose and effects (good and bad) of a new type of targeted cancer therapy called GEN1029 (HexaBody®-DR5/DR5).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer. You must also have already been treated with standard treatments or have no standard treatment available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GEN1029 (HexaBody®-DR5/DR5), by IV, every 2 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Patients with other types of cancers will also be enrolled in this study.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03576131' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/794053' target='_blank'>NCI Drug Dictionary: DR5 HexaBody agonist GEN1029</a> </li></ul>
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324

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 4 visits every 6 weeks, ongoing

PHASE: I

NCT ID: NCT03579472

M7824 and Halaven for Metastatic Triple Negative or ER-Low Breast Cancer

A Phase Ib Trial of M7824 and Eribulin in Patients With Metastatic Triple Negative Breast Cancer (TNBC) Scientific Title

Purpose
To find the best dose of M7824 to use with eribulin (Halaven).
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">M7824, by IV, weekly, for 3 out of every 6 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Eribulin, by IV, weekly, for 4 out of every 6 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">M7824 is an investigational immunotherapy drug. </li> <li class="seamTextUnorderedListItem">It gets immune cells to see cancer cells by blocking PD-L1 and TGF-beta. </li> <li class="seamTextUnorderedListItem">Halaven is used to treat patients who have already had at least two other anticancer medicines for their metastatic breast cancer and who have already been treated with an anthracycline and a taxane for either early or advanced breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03579472' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://immuno-oncologynews.com/io-m7824/' target='_blank'>Immuno-Oncology News: M7824</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.halaven.com/metastatic-breast-cancer' target='_blank'>Drug Company Information Page: Halaven</a> </li></ul>
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325

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 2 visits over 2 weeks

PHASE: I

NCT ID: NCT03620201

M7824 Immunotherapy Before Surgery in Stage II or Stage III HER2+ Breast Cancer

A Pilot Single Arm Open Label Trial Evaluating M7824 (Anti-PD-L1/TGF-Beta TRAP) in a Window Setting in Patients With Stage II-III HER2/Neu Positive (HER2+) Breast Cancer (BC) Scientific Title

Purpose
To study the effects that the experimental immunotherapy M7824 has on tumor-infiltrating lymphocytes.
Who is this for?
People with stage II or stage III HER2 positive breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">M7824, by IV, twice over 2 weeks prior to starting chemotherapy before surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">M7824 is designed to get the immune system to go after cancer cells by targeting PD-L1 and TGFbetaRII. </li> <li class="seamTextUnorderedListItem">Tumor-infiltrating lymphocytes (TILs) are a type of immune cell that has moved from the blood into a tumor to try and attack the cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03620201' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/795582' target='_blank'>NCI Drug Dictionary: M7824</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/29721396' target='_blank'>Oncoimmunology: M7824, a novel fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine.</a> </li></ul>
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326

NEAREST SITE: 1643 miles
Texas Children's Hospital
Houston,TX

VISITS: Hospital stay may be required

PHASE: I

NCT ID: NCT03635632

CAR T-Cell Therapy for Advanced Breast Cancer That Tests Positive for GD2

Phase I Study of Autologous T Lymphocytes Expressing GD2-specific Chimeric Antigen and Constitutively Active IL-7 Receptors for the Treatment of Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Solid Cancers (GAIL-N) Scientific Title

Purpose
To study the safety, best dose, anti-cancer activity and side effects (good and bad) of a new CAR-T cell immunotherapy that targets cancer cells that test positive for GD2.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that tests positive for GD2 and who have already received at least two therapies for advanced disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw to collect white blood cells to make your personalized CAR T-cell therapy (leukapheresis)</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®) and fludarabine (Fludara®), by IV, at least 24 hours before the CAR T-cell immunotherapy is given</li> <li class="seamTextUnorderedListItem">C7R-GD2 CAR T-cell immunotherapy, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule. Hospital stay may be required.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CAR T-cell therapy is a personalized immunotherapy made from your white blood cells. The white blood cells are removed from your body and then modified with chimeric antigen receptors (CARs) so they can attack specific proteins. These white blood cells are then infused into your body. </li> <li class="seamTextUnorderedListItem">The CAR T-cell therapy used in this study trains the immune system to attack cancer cells that test positive for the protein GD2.</li> <li class="seamTextUnorderedListItem">You will receive the chemotherapy drugs cyclophosphamide (Cytoxan®) and fludarabine (Fludara®) before you receive the CAR T-cells. This makes it easier for the CAR T-cells to get into your immune system. </li> <li class="seamTextUnorderedListItem">This study is also enrolling people with other types of advanced cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: GD2</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03635632' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.bcm.edu/research/clinical-trials/h-42207' target='_blank'>Baylor College of Medicine Study Page: GAIL-N</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/car-t-cell-therapy' target='_blank'>NCI Dictionary of Cancer Terms: CAR T-Cell Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/treatment-options/car-t-cell-therapy.html' target='_blank'>MD Anderson Cancer Center: T-Cell Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458232/' target='_blank'>Journal Article: GD2 Expression in Breast Cancer</a> </li></ul>
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327

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03654547

TT-00420 For Advanced Triple Negative or ER-Low Breast Cancer

A Phase I, First-In-Human, Multicenter, Open-Label Study of TT-00420, Administered Orally in Adult Patients With Advanced Solid Tumors and Triple Negative Breast Cancers Scientific Title

Purpose
To study the best dose, safety, and effects (good and bad) of an investigational targeted therapy called TT-00420.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer that has not responded to other treatments.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TT-00420, by mouth, once daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">TT-00420 blocks the growth of the new blood vessels tumors need to grow and targets tumor inflammation.</li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03654547' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://abstracts.asco.org/239/AbstView_239_266885.html' target='_blank'>ASCO abstract: TT-00420</a> </li></ul>
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328

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 3 visits every month, ongoing

PHASE: I

NCT ID: NCT03725436

ALRN-6924 and Paclitaxel for Advanced Breast Cancer

A Phase 1b Study of ALRN-6924 in Combination With Paclitaxel in Wild-Type TP53 Advanced or Metastatic Solid Tumors Including Estrogen-Receptor Positive Breast Cancer Scientific Title

Purpose
To determine the safety and best dose of ALRN-6924 to use in combination with paclitaxel.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer and who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ALRN-6924, by IV, weekly, for 3 weeks out of every month</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 weeks out of every month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ALRN-6924 is a new type of anti-cancer drug that targets MDM2/MDM4, inhibitors of a tumor suppressor protein called p53. </li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancers.</li> <li class="seamTextUnorderedListItem">Targets or mutations: p53</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03725436' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.aileronrx.com/pipeline/' target='_blank'>Sponsor site: ALRN-6924</a> </li></ul>
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329

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03774472

Hydroxychloroquin, Palbociclib & Letrozole for ER+ HER2- Breast Cancer

Phase I/II Safety and Efficacy Study of Autophagy Inhibition With Hydroxychloroquine to Augment the Antiproliferative and Biological Effects of Pre-Operative Palbociclib Plus Letrozole for Estrogen Receptor-Positive and HER2-Negative Breast Cancer Scientific Title

Purpose
To study the safety, best dose and effects (good and bad) of giving hydroxychloroquine along with palbociclib (Ibrance®) and letrozole (Femara®).
Who is this for?
Postmenopausal women with HR positive and HER2 negative breast cancer who has not yet had surgery (if you have stage I, II, or III breast cancer) and has not been treated with a CDK 4/6 inhibitor (if you have metastatic (stage IV) breast cancer).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following treatment by mouth, daily for 1 year: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hydroxychloroquine</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®)</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Participants with early stage (stage I-III) breast cancer will undergo standard surgery after 1 or 5-6 months.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hydroxychloroquine is a drug that decreases immune responses in the body. It is routinely used to prevent or to treat malaria and some auto-immune diseases. </li> <li class="seamTextUnorderedListItem">Ibrance is a targeted drug that is given along with hormone therapy to treat metastatic breast cancer in postmenopausal women. </li> <li class="seamTextUnorderedListItem">Femara is an aromatase inhibitor used to treat early-stage and metastatic breast cancer in postmenopausal women. It is approved for use along with Ibrance.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03774472' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-5482/hydroxychloroquine-oral/details' target='_blank'>WebMD: Hydroxychloroquine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718030/' target='_blank'>NCBI: Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents</a> </li></ul>
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330

NEAREST SITE: 1643 miles
Kymab investigator site 1101
Houston,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03829501

KY1044 and Immunotherapy Atezolizumab for Advanced Triple Negative Breast Cancer

A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of KY1044 as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of using immunotherapy KY1044 alone or with the PD-1 inhibitor Tecentriq® (atezolizumab).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-,PR-,HER2-) breast cancer that has not responded to other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Monotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">KY1044</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Combination Therapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">KY1044</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">KY1044 stimulates immune cells to go after and kill cancer cells. </li> <li class="seamTextUnorderedListItem">It also kills the T regulatory cells that keep immune cells from killing the cancer cells.</li> <li class="seamTextUnorderedListItem">Tecentriq® (atezolizumab) is a type of immunotherapy called a PD-L1 (programmed cell death-ligand 1) inhibitor. </li> <li class="seamTextUnorderedListItem">It is approved to treat advanced triple negative breast cancer, as well as certain types of bladder and lung cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03829501' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.kymab.com/news-and-events/news/2017/nov/8/ky1044-anti-icos-antibody-sitc/' target='_blank'>Drug Sponsor Site: KY1044</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertherapyadvisor.com/home/news/conference-coverage/american-society-of-clinical-oncology-asco/asco-2018/first-in-class-icos-agonist-alone-or-in-combination-may-be-effective-for-advanced-cancer/' target='_blank'>StatNews: Tecentriq approval for breast cancer</a> </li></ul>
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331

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03872388

Atorvastatin in Stages IIb-III TNBC After Neoadjuvant Therapy & Surgery

Atorvastatin in Triple-Negative Breast Cancer (TNBC) Patients Who Did Not Achieve a Pathologic Complete Response (pCR) After Receiving Neoadjuvant Chemotherapy, a Multicenter Pilot Study Scientific Title

Purpose
To study the effects (good and bad) of atorvastatin (Lipitor®).
Who is this for?
People with stage IIb or stage III triple negative (ER-, PR- and HER2-) breast cancer that did not fully respond to neoadjuvant chemotherapy (treatment given before surgery).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atorvastatin, by mouth, once a day, for up to 2 years</li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, 2 times daily, 2 weeks on and 1 week off </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard treatment</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, 2 times daily, 2 weeks on and 1 week off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atorvastatin (Lipitor®) is used to treat high cholesterol and may also be effective in treating triple negative breast cancer. </li> <li class="seamTextUnorderedListItem">Your doctor will decide whether you should receive the breast cancer drug capecitabine (Xeloda®) while you are in this study.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03872388' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.drugs.com/atorvastatin.html' target='_blank'>Drugs.com: Atorvastatin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/community/bonnie-annis/2018/03/do-statins-contribute-to-cancer-recurrence' target='_blank'>Cure today: Do Statins Contribute to Cancer Recurrence?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medscape.com/viewarticle/889813' target='_blank'>Medscape: Statins May Up Breast Cancer–Specific and Overall Survival</a> </li></ul>
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332

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: 2 visits every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03992131

Rubraca & Sacituzumab Govitecan for Metastatic Triple Negative Breast Cancer

SEASTAR: A Phase 1b/2, Open-label, Parallel Arm Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Oral Rucaparib in Combination With Other Anticancer Agents in Patients With a Solid Tumor Scientific Title

Purpose
To study the safety and effects (good and bad) of the combination of rucaparib (Rubraca®) and sacituzumab govitecan.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that has been treated with at least one standard therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rucaparib (Rubraca®), by mouth, twice daily, ongoing</li> <li class="seamTextUnorderedListItem">Sacituzumab govitecan (IMMU-132), by IV, 2 times every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rubraca is a PARP inhibitor approved to treat recurrent ovarian, fallopian tube, and primary peritoneal cancer. </li> <li class="seamTextUnorderedListItem">Sacituzumab govitecan is a type of cancer therapy called an antibody-drug conjugate (ADC). It uses an antibody that targets cancer cells to deliver the drug SN-38 directly to these cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03992131' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/rucaparib-phosphate' target='_blank'>NCI Drug Dictionary: Rucaparib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.clovisoncology.com/pipeline/rucaparib/' target='_blank'>Drug company information site: Rucaparib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sacituzumab-govitecan' target='_blank'>NCI Drug Dictionary: Sacituzumab govitecan</a> </li></ul>
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333

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit every 2 or 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT04108858

Copanlisib for Stage IV HER2 Positive Breast Cancer with a PIK3CA or PTEN Mutation

Phase Ib/II Trial of Copanlisib in Combination With Trastuzumab and Pertuzumab After Induction Treatment of HER2 Positive (HER2+) Metastatic Breast Cancer (MBC) With PIK3CA Mutation or PTEN Mutation Scientific Title

Purpose
To study the best dose, effects (good and bad), and anti-cancer activity of adding copanlisib (Aliqopa®) to the combination of trastuzumab (Herceptin®) and pertuzumab (Perjeta®).
Who is this for?
People with metastatic (stage IV) HER2 positive (HER2+) breast cancer that tests positive for a PIK3CA or PTEN mutation and who have already received chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Copanlisib (Aliqopa®), by IV, every week (2 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Copanlisib (Aliqopa®) is a type of targeted therapy called a PI3K inhibitor. It is approved for use in lymphoma, but its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) are targeted therapies routinely used to for HER2 positive breast cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA (PI3K) and PTEN</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04108858' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.aliqopa-us.com/?utm_source=google&utm_medium=cpc&utm_campaign=Aliqopa_Branded_Patient_%3BS%3BPH%3BBR%3BONC%3BDTC%3BBR&utm_content=General&utm_term=copanlisib&matchtype=e&device=c&adposition=&loc=9008590&gclid=Cj0KCQjwjer4BRCZARIsABK4QeVEb_yjzH' target='_blank'>Bayer Drug Information Page: Aliqopa® (Copanlisib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies' target='_blank'>Breastcancer.org: Targeted Therapies</a> </li></ul>
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334

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT04143711

Immunotherapy DF1001 Alone or With Keytruda® for IHC HER2 1+, 2+ or 3+ Metastatic Breast Cancer

A Phase I/II, First-In-Human, Multi-Part, Open-Label, Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF1001 in Patients With Locally Advanced or Metastatic Solid Tumors, and Expansion in Selected Indications Scientific Title

Purpose
To study the safety, effects (good and bad), and best dose of DF1001 when it is given alone or with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer that tests HER2 1+, 2+ or 3+ on the IHC (immunohistochemistry) tumor test and have not had more than three lines of chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DF1001 immunotherapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">You may also receive:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DF1001 is an experimental immunotherapy. </li> <li class="seamTextUnorderedListItem">Keytruda® is a type of immunotherapy called a PD-L1 inhibitor. It is approved to treat certain types of cancers. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04143711' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/msi-h/' target='_blank'>Merck Oncology Information Page: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.dragonflytx.com/copy-of-about-us-1' target='_blank'>Dragonfly Therapeutics Information Page: DF1001</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554437/' target='_blank'>Journal Article: Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/articles/keytruda-approved-for-microsatellite-instability-high-and-mismatch-repair-deficient-cancers' target='_blank'>Cure Today: Keytruda Approved for Any Solid Tumor With a Specific Genetic Marker</a> </li></ul>
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335

NEAREST SITE: 1643 miles
Investigational Site
Houston,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT04143789

AP-002 for Advanced Breast Cancer

A Phase 1/2 Dose Escalation Study of AP-002 In Patients With Advanced or Recurrent Solid Tumors Scientific Title

Purpose
To look at the safety, best dose, and anti-tumor activity of an experimental targeted therapy called AP-002.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer and have no standard treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AP-002, by mouth, daily, 2 weeks on, 1 week off, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04143789' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.altumpharma.com/pipeline/ap-002/' target='_blank'>Drug Company Information Page: AP-002</a> </li></ul>
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336

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04182516

NMS-03305293 for People With Advanced HER2 Negative Breast Cancer and an Inherited BRCA1/2 Mutation

A Phase I Dose Escalation Study of NMS-03305293 in Adult Patients With Selected Advanced/Metastatic Solid Tumors Scientific Title

Purpose
To look at the safety, effects (good and bad), and anti-tumor activity of the targeted therapy NMS-03305293.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV), HER2 negative (HER2-) breast cancer who have an inherited BRCA 1 or BRCA 2 mutation and no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NMS-03305293, by mouth, daily (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NMS-03305293 is a PARP inhibitor. It works by blocking the action of poly (ADP-ribose) polymerase, an enzyme that helps repair DNA.</li> <li class="seamTextUnorderedListItem">NMS-03305293 is an experimental drug, which means it is only available in clinical trials. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04182516' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/parp-inhibitors-in-breast-cancer-treatment' target='_blank'>Breast Cancer Now: PARP Inhibitors</a> </li></ul>
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337

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit a week, for 9 weeks

PHASE: II

NCT ID: NCT04216472

Nab-paclitaxel and Alpelisib for Stage I-III Triple Negative Breast Cancer with a PIK3CA or PTEN Mutation

A Phase-2, Two-Cohort Trial of Neoadjuvant Nab-Paclitaxel and Alpelisib in Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations Scientific Title

Purpose
To study the anti-tumor activity and effects (good and bad) of combining the chemotherapy nab-paclitaxel (Abraxane®) with the targeted therapy alpelisib (Piqray®).
Who is this for?
People with stage I, stage II, or stage III triple negative (ER-, PR-, HER2-) breast cancer who have had an anthracycline-based chemotherapy that did not make their tumor disappear, have not yet had surgery, and whose tumor tests positive for or expresses one of the following: PIK3CA or PTEN.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Before surgery, you will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, once a week, for 9 weeks</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily, for 9 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®) is a chemotherapy drug routinely used to treat advanced breast cancer.</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®) is a targeted therapy called a PI3K inhibitor.</li> <li class="seamTextUnorderedListItem">If there is a mutation in the PIK3CA gene, the PI3K pathway can become overactivated, which allows cancer cells to grow.</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®) is approved for use in metastatic HR+, HER2- breast cancer that tests positive for a mutation in the PIK3CA gene. Its use in this trial is considered experimental. </li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA, PTEN</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04216472' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/diagnosis/trip_neg' target='_blank'>Breastcancer.org: Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hcp.novartis.com/products/piqray/metastatic-breast-cancer/?site=PIQ-1221443GK100070&source=01030&gclid=Cj0KCQjw09HzBRDrARIsAG60GP8NmxZEpBut51InBn-RSi3suu6WOtcycuwZHt4pRFtkVUYNZBtpxGoaAjQJEALw_wcB&gclsrc=aw.ds' target='_blank'>Novartis Pharmaceuticals Information Page: Piqray® (Alpelisib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/issues/december-25-2018/association-between-pathologic-complete-response-after-neoadjuvant-chemotherapy-and-breast-cancer-outcomes/' target='_blank'>ASCO: Association Between Pathologic Complete Response After Neoadjuvant Chemotherapy and Breast Cancer Outcomes</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertreatmentreviews.com/article/S0305-7372(16)30083-4/fulltext' target='_blank'>Journal Article: Nab-paclitaxel for the Treatment of Triple-negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/full/10.1200/EDBK_175631' target='_blank'>Journal Article: Novel Targeted Agents and Immunotherapy in Breast Cancer</a> </li></ul>
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338

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04234113

SO-C101 (Immunotherapy) Alone or With Pembrolizumab In Advanced Triple Negative Breast Cancer

A Multicenter Open-label Phase 1/1b Study to Evaluate the Safety and Preliminary Efficacy of SO-C101 as Monotherapy and in Combination With Pembrolizumab in Patients With Selected Advanced/Metastatic Solid Tumors Scientific Title

Purpose
To study the safety, best dose, anti-tumor activity and effects (good and bad) of the experimental immunotherapy drug SO-C101 (RLI-15) when it is given alone or in combination with pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have no standard treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SO-C101</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SO-C101</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SO-C101 (RLI-15) is a new type of immunotherapy that works by getting immune cells called natural killer cells to kill cancer cells. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. It is approved to treat certain types of cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04234113' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sotio.com/pipeline/so-c101' target='_blank'>Drug Company Information Page: SO-C101 (RLI-15)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=CjwKCAiA1rPyBRAREiwA1UIy8AIFO2xkZ72nv59oRzgEL2_j5xbdlfT_f9w1NuFPTrkeUqYvN9yqxxoCBOYQA' target='_blank'>Merk Oncology Drug Information: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerhealth.com/article/immunotherapies-show-mixed-results-triplenegative-breast-cancer' target='_blank'>Cancer Health: Immunotherapies Show Mixed Results for Triple-Negative Breast Cancer</a> </li></ul>
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339

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT04256941

Fulvestrant For Metastatic Hormone Positive Breast Cancer with an ERS1 Mutation (INTERACT)

INTERACT- Integrated Evaluation of Resistance and Actionability Using Circulating Tumor DNA in HR Positive Metastatic Breast Cancers Scientific Title

Purpose
To compare the safety and effectiveness of combining a CDK 4/6 inhibitor with fulvestrant (Faslodex®) to a CDK 4/6 inhibitor and a standard of care aromatase inhibitor, on tumors that test positive for ESR1.
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+) breast cancer who are currently on a CDK4/6 inhibitor and an aromatase inhibitor and whose tumor tests positive for ESR1.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Your current CDK 4/6 inhibitor, by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, monthly (2 times the first month)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Your current CDK 4/6 inhibitor, by mouth</li> <li class="seamTextUnorderedListItem">Your current aromatase inhibitor, by mouth</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a hormone therapy approved to treat hormone-sensitive HER2-negative advanced breast cancer in postmenopausal women.</li> <li class="seamTextUnorderedListItem">Targets or mutations: ESR1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04256941' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/erds/faslodex' target='_blank'>Breastcancer.org: Fulvestrant (Faslodex®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncnursingnews.com/web-exclusives/overcoming-ai-resistance-in-esr1mutant-breast-cancer' target='_blank'>Oncology Nursing News: Overcoming AI Resistance in ESR1-Mutant Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/CDK46inhibitorsfortreatmentofmetastaticbreastcancer.html' target='_blank'>Susan G. Komen: CDK4/6 Inhibitors for Treatment of Metastatic Breast Cancer</a> </li></ul>
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340

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Hospital stay may be required

PHASE: I

NCT ID: NCT04319757

Immunotherapy ACE1702 for Advanced HER2 Expressing (HER2 IHC 2+ or 3+) Breast Cancer

A Phase I, Open Label, Dose Escalation Study of ACE1702 Cell Immunotherapy in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors Scientific Title

Purpose
To study the safety, anti-cancer activity, and effects (good and bad) of an experimental natural killer (NK) cell immunotherapy that targets HER2-expressing cancer cells.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2-expressing (HER2 IHC 2+ or 3+) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®) and fludarabine (Fludara®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ACE1702 natural killer cell immunotherapy (anti-HER2 oNK cells), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule. Hospital stay may be required.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ACE1702 is the natural killer (NK) cell immunotherapy used in this trial. </li> <li class="seamTextUnorderedListItem">Before you receive ACE1702, you will be given the chemotherapy drugs fludarabine and cyclophosphamide. These drugs are used to prepare your immune system to receive the NK immunotherapy.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04319757' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.acepodia.com/pipeline' target='_blank'>Acepodia Drug Information Page: ACE1702</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Natural_killer_cell' target='_blank'>Wikipedia: Natural Killer Cell</a> </li></ul>
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341

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Weekly visits

PHASE: I

NCT ID: NCT04429542

BCA101 for Metastatic Triple Negative Breast Cancer That Tests Positive for EGFR

First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFβ Fusion Protein BCA101 Alone and in Combination With Pembrolizumab in Patients With EGFR-Driven Advanced Solid Tumors Scientific Title

Purpose
To study the safety, anti-cancer activity, and effects (good and bad) of the targeted therapy BCA101.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that tests positive for EGFR amplification and who have no other treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BCA101, by IV, once a week, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BCA101 targets the EGFR and TGFβ pathways. </li> <li class="seamTextUnorderedListItem">It is an experimental targeted therapy, this means it is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of metastatic cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: EGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04429542' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://europepmc.org/article/med/27648353' target='_blank'>Journal Article Abstract: A Perspective on Anti-EGFR Therapies Targeting Triple Negative Breast Cancer.</a> </li></ul>
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342

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: 1 visit every 3 weeks

PHASE: I

NCT ID: NCT04432857

AN0025 and Pembrolizumab for Advanced Triple Negative Breast Cancer

An Open-Label Multicenter Phase Ib Study of AN0025 in Combination With Pembrolizumab in Patients With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, anti-cancer activity, and side effects of combining the experimental targeted therapy AN0025 with the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have received no more than 3 prior therapies for advanced disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AN0025, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AN0025 is an experimental targeted therapy. This means it is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor/checkpoint inhibitor. It is approved for use in other cancers but its use for breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04432857' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.adlainortye.com/en_product.php' target='_blank'>Adlai Nortye Drug Information Page: AN0025</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/keytruda-plus-chemo-better-than-chemo-alone-for-some' target='_blank'>Breastcancer.org: Keytruda Plus Chemotherapy Offers More Benefits Than Chemo Alone as First Treatment for Metastatic Triple-Negative Breast Cancer With High Levels of PD-L1</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor+KEYTRUDA+ONLY_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=Cj0KCQjwpNr4BRDYARIsAADIx9zN_JT9uThoV9MYlllBnCVVYDzP8fCogm1trpDps_D9ZqW' target='_blank'>Merck Oncology Drug Information Page: Keytruda® (Pembrolizumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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343

NEAREST SITE: 1655 miles
University of Iowa Hospitals and Clinics
Iowa City,IA

VISITS: Weekly visits for 3 months

PHASE: II

NCT ID: NCT03642990

Vitamin B3 to Reduce Paclitaxel-Related Peripheral Neuropathy in Metastatic Breast Cancer

Nicotinamide Riboside (NR) in Paclitaxel-induced Peripheral Neuropathy Scientific Title

Purpose
To determine whether nicotinamide riboside (Niagen®) prevents the progression of peripheral neuropathy.
Who is this for?
People with stage IV metastatic breast cancer that is being treated with paclitaxel (Taxol®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nicotinamide Riboside (Niagen®), by mouth, twice daily for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nicotinamide riboside (NR) is a vitamin B3 supplement. </li> <li class="seamTextUnorderedListItem">Studies suggest it may help prevent or treat nerve pain. </li> <li class="seamTextUnorderedListItem">Neuropathy--pain or numbness in the hands and feet--is a type of nerve pain. </li> <li class="seamTextUnorderedListItem">It is a common side effect of certain types of chemotherapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03642990' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/neuropathy' target='_blank'>Breastcancer.org: Neuropathy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medcom.uiowa.edu/theloop/news/nicotinamide-riboside-vitamin-b3-prevents-nerve-pain-caused-by-cancer-drugs' target='_blank'>University of Iowa: Nicotinamide riboside (vitamin B3) prevents nerve pain caused by cancer drugs</a> </li></ul>
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344

NEAREST SITE: 1655 miles
University of Iowa Hospital and Clinics
Iowa City,IA

VISITS: Weekly visits, ongoing

PHASE: I-II

NCT ID: NCT03911973

Gedatolisib and Talazoparib in Advanced HER2 Negative, Inherited BRCA1/2+ or Triple Negative Breast Cancer

Phase 2 Trial With Safety Run-In of Gedatolisib Plus Talazoparib in Advanced Triple Negative or BRCA1/2 Positive, HER2 Negative Breast Cancers Big Ten Cancer Research Consortium BTCRC-BRE18-337 Scientific Title

Purpose
To determine the safety, best dose, and effects (good and bad) of gedatolisib when it is used in combination with talazoparib (Talzenna®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer whose cancer is triple negative (ER-, PR-, HER2-) or who have an inherited BRCA1 or BRCA2 mutation and HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by IV, once a week </li> <li class="seamTextUnorderedListItem">Gedatolisib, by IV, once a day</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gedatolisib is an experimental targeted therapy that works by blocking two proteins, called PI3K and mTOR, that help tumors grow. </li> <li class="seamTextUnorderedListItem">Talzenna is a type of targeted therapy called a PARP inhibitor. It is approved to treat HER2 negative advanced or metastatic breast cancer in people with an inherited BRCA mutation.</li> <li class="seamTextUnorderedListItem">Targets or mutations: inherited BRCA 1 and BRCA 2 mutations.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03911973' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-approves-talazoparib-for-brcamutated-her2negative-breast-cancer' target='_blank'>OncLive: FDA Approves Talazoparib for BRCA-Mutated, HER2- Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pfizer.com/files/news/asco/Pfizer_IO_GetaPI3KFactSheet.pdf' target='_blank'>Pfizer Oncology Information Page: Gedatolisib</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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345

NEAREST SITE: 1678 miles
University of Wisconsin Carbone Cancer Center
Madison,WI

VISITS: Weekly visits for 3 months

PHASE: NA

NCT ID: NCT03096418

Taxol Before Surgery for Stage I-III Breast Cancer

Neoadjuvant Weekly Paclitaxel and Biomarkers of Therapy Response Scientific Title

Purpose
To study the effects (good and bad) that the chemotherapy drug, paclitaxel (Taxol®), has on the tumor.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who have not yet had breast surgery or any other treatment for their cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for up to 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A chemotherapy drug will be given before surgery (neoadjuvant treatment). </li> <li class="seamTextUnorderedListItem">Giving chemotherapy before surgery can shrink the tumor. </li> <li class="seamTextUnorderedListItem">It also lets researchers study whether the drug works better for certain types of tumors. </li> <li class="seamTextUnorderedListItem">The chemotherapy drug being used in this study is paclitaxel (Taxol®). It is commonly used to treat breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03096418' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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346

NEAREST SITE: 1678 miles
University of Wisconsin Carbone Cancer Center
Madison,WI

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03733119

ONC201 and Methionine-Restricted Diet in Patients With Advanced Triple Negative Breast Cancer

ONC201 With and Without Methionine-Restricted Diet in Patients With Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To compare the safety and effects (good and bad) of a targeted therapy called ONC201 in patients who are or are not on a methionine-restricted (low-protein) diet.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONC201, by mouth, once a week, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONC201, by mouth, once a week, ongoing</li> <li class="seamTextUnorderedListItem">Methionine-Restricted Diet, 5 days a week, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONC201 is an experimental targeted therapy that targets Akt/ERK and can lead to the death of a tumor cell. </li> <li class="seamTextUnorderedListItem">Methionine is an essential amino acid that is found in foods that contain protein. </li> <li class="seamTextUnorderedListItem">The researchers want to see if restricting the amount of methionine in a patient's diet affects how the cancer responds to the drug ONC201.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03733119' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedaily.com/releases/2018/05/180508155031.htm' target='_blank'>ScienceDaily: ONC201 kills breast cancer cells in vitro by targeting mitochondria</a> </li><li class='seamTextUnorderedListItem'><a href='https://integrativeoncology-essentials.com/2014/07/kill-cancer-restricting-methionine-rich-foods/' target='_blank'>Integrative Oncology Essentials: Kill Cancer By Restricting Methionine-Rich Foods</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedaily.com/releases/2018/03/180322140921.htm' target='_blank'>Science Daily: Methionine-restricted diet</a> </li></ul>
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347

NEAREST SITE: 1718 miles
Siteman Cancer Center at Saint Peters Hospital
Saint Peters,MO

VISITS: 2-3 visits the first month, then 1 to 3 visits a month thereafter

PHASE: I-II

NCT ID: NCT03939897

Fulvestrant & Abemaciclib with and without Copanlisib in Metastatic HR+, HER2- Breast Cancer

A Randomized Phase I/II Trial of Fulvestrant and Abemaciclib in Combination With Copanlisib (FAC) Versus Fulvestrant and Abemaciclib Alone (FA) for Endocrine-Resistant, Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer (FAC vs FA) Scientific Title

Purpose
To compare the effects (good and bad) of giving the CDK 4/6 inhibitor abemaciclib (Verzenio®) and the anti-hormone drug fulvestrant (Faslodex®) with or without the PI3K inhibitor copanlisib (Aliqopa®).
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer treated with no more than one chemotherapy for metastatic disease and your cancer must have progressed during or after hormone therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Copanlisib (Aliqopa®), by IV, 2 or 3 times a month</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, twice a day</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice the first month, then monthly thereafter</li> <li class="seamTextUnorderedListItem">If you are premenopausal, an ovarian suppression drug, by injection, monthly</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, twice a day</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice the first month, then monthly thereafter</li> <li class="seamTextUnorderedListItem">If you are premenopausal, an ovarian suppression drug, by injection, monthly</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Copanlisib (Aliqopa®) is a type of targeted therapy called a PI3K inhibitor. It is approved for use in lymphoma, but its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®) is a type of targeted therapy called a CDK 4/6 inhibitor. It is approved for use in people with metastatic hormone positive (ER+ and/or PR+) breast cancer.</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is approved to treat certain people with metastatic hormone positive (ER+ and/or PR+) breast cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PI3K</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03939897' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/verzenio' target='_blank'>Breastcancer.org: Verzenio (Abemaciclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a617044.html' target='_blank'>MedLine Plus: Copanlisib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hcp.aliqopa-us.com/mechanism-of-action/' target='_blank'>Bayer Information Page: Aliqopa® (Copanlisib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/hormone-therapy/ovarian-suppression-breast-cancer' target='_blank'>Breast Cancer Now: Ovarian Suppression and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hematologyandoncology.net/archives/september-2019/phosphoinositide-3-kinase-inhibition-in-the-treatment-of-hormone-receptor-positive-breast-cancer/' target='_blank'>Journal Article: Phosphoinositide 3-Kinase Inhibition in the Treatment of Hormone Receptor–Positive Breast Cancer</a> </li></ul>
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348

NEAREST SITE: 1718 miles
Saint Luke's Cancer Institute
Saint Peters,MO

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04288089

H3B-6545 & Palbociclib for Women with Advanced ER+, HER2- Breast Cancer

An Open-Label Multicenter Phase 1b Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive HER2-Negative Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of giving the experimental anti-estrogen therapy H3B-6545 in combination with the targeted therapy palbociclib (Ibrance®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have already at least one therapy for advanced or metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, ongoing</li> <li class="seamTextUnorderedListItem">H3B-6545, by mouth, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">H3B-6545 is an experimental anti-estrogen therapy that targets ER alpha (estrogen receptor alpha).</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is commonly used in combination with approved anti-estrogen therapies for metastatic hormone positive, HER2 negative breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04288089' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793979' target='_blank'>NCI Drug Dictionary: H3B-6545</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com/about-ibrance#faq' target='_blank'>Pfizer Oncology Drug Information Page: Ibrance® (Palbociclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/targeted-therapy/palbociclib-ibrance' target='_blank'>Breast Cancer Now: Palbociclib</a> </li></ul>
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349

NEAREST SITE: 1728 miles
Mercy David C. Pratt Cancer Center
Saint Louis,MO

VISITS: Periodic visits for 3 years; then 1-3 visits per week for 1 month if needed

PHASE: NA

NCT ID: NCT03292198

L-Dex to Identify Breast Cancer-Related Lymphedema

Treatment Indications for Breast Cancer-related Subclinical Lymphedema Identified Through a Bioimpedance Surveillance Model Scientific Title

Purpose
To evaluate whether routine screening with L-Dex to detect lymphedema early improves patient outcomes.
Who is this for?
Women whose breast cancer surgery will include a sentinel lymph node biopsy or axillary lymph node dissection.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive periodic screening with L-dex for 3 years following surgery. If you develop lymphedema, you will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Wear compression sleeves and gloves, daily, for 1 month</li> <li class="seamTextUnorderedListItem">L-dex measurement, weekly </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Manual Lymphatic Drainage, 3 times per week, for 1 month</li> <li class="seamTextUnorderedListItem">Wear compression sleeves and gloves, daily, for 1 month</li> <li class="seamTextUnorderedListItem">L-dex measurement, weekly</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a common side effect after breast cancer surgery. </li> <li class="seamTextUnorderedListItem">It causes pain and swelling in the hands and arms. </li> <li class="seamTextUnorderedListItem">L-Dex is a portable system that uses a small electrical current to detect the build up of lymphatic fluid before it begins to cause side effects. </li> <li class="seamTextUnorderedListItem">Patients who develop lymphedema will be randomized to receive one of two treatment plans for breast cancer-related lymphedema.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03292198' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nice.org.uk/advice/mib111/chapter/The-technology' target='_blank'>National Institute for Health and Care Excellence UK: L-Dex</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li></ul>
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350

NEAREST SITE: 1734 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: Coincides with surgical appointments

PHASE: NA

NCT ID: NCT00353483

Studying Disseminated Cancer Cells Before and After Chemotherapy

Effect of Neoadjuvant Chemotherapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells Scientific Title

Purpose
To compare the tumor markers seen on DTCs detected prior to chemotherapy to the tumor markers seen on any DTCs present after chemotherapy.
Who is this for?
People with stage II, stage III, or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Breast cancer tissue, peripheral blood, and bone marrow will be collected 3-4 times: </p> <ol> <li>During surgery for a sentinel lymph node biopsy or portacath placement</li> <li>During breast cancer surgery (if surgery occurs)</li> <li>At one year</li> <li>If metastatic disease develops</li></ol>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Single tumor cells or small groups of tumor cells that are found in the lymph or blood are often referred to as disseminated tumor cells (DTCs). </li> <li class="seamTextUnorderedListItem">Chemotherapy that is given before surgery may not kill all cancer cells. </li> <li class="seamTextUnorderedListItem">DTCs that are not killed by chemotherapy are believed to have a unique set of tumor marker proteins.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00353483' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://scholar.google.com/scholar?hl=en&q=disseminated+cancer+cells+breast+cancer&btnG=&as_sdt=1%2C5&as_sdtp=' target='_blank'>Google Scholar: disseminated cancer cells</a> </li></ul>
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351

NEAREST SITE: 1735 miles
Siteman Cancer Center- Washington University School of Medicine in St. Louis
Saint Louis,MO

VISITS: 1 visit every 2 weeks, ongoing

PHASE: II

NCT ID: NCT02422641

Methotrexate in Metastatic Breast Cancer With Leptomeningeal Metastasis

Traditional Incision and Drainage of Cutaneous Abscess Vs. Minimally Invasive Incision and Drainage With Vessel Loop: A Randomized Controlled Trail Scientific Title

Purpose
To study the effects (good and bad) of using high-dose methotrexate to treat metastases in the cerebrospinal fluid surrounding the brain and spinal cord and/or in the leptomeninges (the lining of the brain and spinal cord).
Who is this for?
People with metastatic (stage IV) breast cancer with leptomeningeal metastases.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High-dose Methotrexate (HD-MTX), by IV, once every 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metastases in the cerebrospinal fluid surrounding the brain and spinal cord and/or in the leptomeninges (the lining of the brain and spinal cord) is called leptomeningeal disease. </li> <li class="seamTextUnorderedListItem">Methotrexate is a chemotherapy drug approved to treat advanced breast cancer.</li> <li class="seamTextUnorderedListItem">Researchers believe methotrexate can cross the blood-brain barrier, which will allow the drug to reach the leptomeningeal metastases.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02422641' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/cancerwise/2017/04/new-hope-for-leptomeningeal-disease-care.html' target='_blank'>MDAnderson: New Hope for Leptomeningeal Disease Care</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.brainmetsbc.org/content/leptomeningeal-metastases' target='_blank'>BrainMetsBC.org: Leptomeningeal Metastases</a> </li></ul>
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352

NEAREST SITE: 1735 miles
Washington University
Saint Louis,MO

VISITS: 1 visit per week

PHASE: I

NCT ID: NCT03767335

MEN1611 & Trastuzumab In Advanced HER2 Positive Breast Cancer With A PIK3CA Mutation

Open-label, Multicentre, Phase Ib Dose-escalation Study of MEN1611, a PI3K Inhibitor Combined With Trastuzumab With or Without Fulvestrant, in Subjects With PIK3CA Mutated HER2 Positive Locally Recurrent Unresectable (Advanced) or Metastatic (a/m) Breast Cancer Progressed to Anti-HER2 Based Therapy Scientific Title

Purpose
To study the best dose, safety, side effects, and anti-cancer activity of giving the experimental PI3K inhibitor MEN1611 in combination with the anti-HER2 targeted therapy trastuzumab (Herceptin®), with and without the anti-hormone drug fulvestrant (Faslodex®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 positive (HER2+), breast cancer whose tumor has a PIK3CA mutation and whose disease progressed after receiving trastuzumab (Herceptin®) and at least one other anti-HER2 therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MEN1611, by mouth, daily</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) by IV, weekly</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, monthly (only if you are postmenopausal and your cancer is hormone positive)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MEN1611 is a type of targeted therapy called a PI3K inhibitor. PI3K is a protein that is involved in cancer cell growth. MEN1611 blocks this protein.</li> <li class="seamTextUnorderedListItem">MEN1611 is an investigational drug, which means it is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) is an anti-HER2 targeted therapy. It is commonly used to treat people with HER2 positive (HER2+) breast cancer. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a hormone therapy that is commonly used to treat postmenopausal women with metastatic, hormone positive (ER+ and/or PR+) breast cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03767335' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.menarini.com/Home/Innovation-Research/MEN1611' target='_blank'>The Menarini Group Information Page: MEN1611</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verywellhealth.com/pik3ca-mutations-in-metastatic-breast-cancer-4689488' target='_blank'>Verywell Health: PIK3CA Mutations in Metastatic Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/trastuzumab' target='_blank'>NCI A to Z List of Cancer Drugs: Trastuzumab</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/fulvestrant.aspx' target='_blank'>Chemocare: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.faslodex.com/home.html' target='_blank'>AstraZeneca Information Page: Faslodex (Fulvestrant)</a> </li></ul>
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353

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: 7 visits over 6 months

PHASE: I

NCT ID: NCT02427581

Breast Cancer Vaccine for Triple Negative Breast Cancer Following Chemo Before Surgery

A Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy Scientific Title

Purpose
To study the best dose and effects (good and bad) of using a personalized synthetic long peptide vaccine.
Who is this for?
Women with stage II or stage III triple negative (ER-, PR-, HER2-) breast cancer who received neoadjuvant (before surgery) chemotherapy and still had cancer cells in their breast during surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Personalized synthetic long peptide breast cancer vaccine, 4 injections in the first 10 days, then 3 additional injections over 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A peptide is a naturally occurring biological molecule made up of amino acids. </li> <li class="seamTextUnorderedListItem">Researchers have developed a way to create a personalized synthetic long peptide vaccine that can generate an immune response to breast cancer cells by targeting mutations specific to a person's tumor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02427581' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2015-01050&r=1' target='_blank'>NCI Study Website: Personalized Vaccine Therapy in Treating Patients with Triple-Negative Breast Cancer</a> </li></ul>
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354

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: Number of visits unavailable, over 5 months

PHASE: II

NCT ID: NCT02124902

Taxotere and Paraplatin Before Surgery in Women with Stage II-III, Triple Negative or ER-, HER2- Breast Cancer

A Co-clinical Trial in Triple Negative Breast Cancer Patients With Genoproteomic Discovery Scientific Title

Purpose
To study the effects (good and bad) that docetaxel (Taxotere®) and carboplatin (Paraplatin®) have on breast cancer cells.
Who is this for?
Women with stage II or stage III triple negative (ER-, PR-, HER2-) or ER negative, HER2 negative breast cancer    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®) by IV</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) by IV</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This trial is enrolling women with triple negative (ER-, PR-, HER2-) and estrogen receptor negative, progesterone receptor positive, HER2 negative (ER-, PR+, HER2-) breast cancer. </li> <li class="seamTextUnorderedListItem">Giving chemotherapy before surgery, called neoadjuvant therapy, allows researchers to study the effect that the treatment has on cancer cells.</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®) is a chemotherapy drug commonly used to treat advanced breast cancer.</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) is a chemotherapy drug used to treat advanced breast cancer that has not responded to previous chemotherapy treatments.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02124902' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://ww5.komen.org/BreastCancer/Neoadjuvant.html' target='_blank'>Susan G. Komen: Neoadjuvant Thearpy</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/druglist/taxotere' target='_blank'>Breastcancer.org: Docetaxel</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/pdq/treatment/breast/healthprofessional/page8' target='_blank'>NCI: Triple-Negative Breast Cancer</a> </li></ul>
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355

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: Visits monthly over 3 months

PHASE: I

NCT ID: NCT02204098

Mammaglobin-A DNA Vaccine + Hormone Therapy Before Surgery for ER+, HER2- Breast Cancer

A Phase 1B Randomized Clinical Trial to Evaluate the Safety and Immune Response to a Mammaglobin-A DNA Vaccine in Breast Cancer Patients Undergoing Neoadjuvant Endocrine Therapy Scientific Title

Purpose
To compare the immune response from a mammaglobin-A DNA vaccine along with hormone therapy or hormone therapy alone before surgery.
Who is this for?
Women with stage II or stage III estrogen receptor positive (ER+), HER2 negative breast cancer. You must not have yet received any anti-cancer therapy including surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Mammaglobin-A DNA Vaccine</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy (Physician's choice), before surgery</li> <li class="seamTextUnorderedListItem">Mammaglobin-A DNA vaccine, by injection, monthly over 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy (Physician's choice), before surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mammaglobin-A is a protein that is highly expressed by breast cancer cells. </li> <li class="seamTextUnorderedListItem">Laboratory studies suggest a mammaglobin-A DNA vaccine may trigger the body's immune system to destroy cancer cells. </li> <li class="seamTextUnorderedListItem">Hormone therapies are used to treat hormone-sensitive tumors. </li> <li class="seamTextUnorderedListItem">These medications include anastrozole (Arimidex®), letrozole (Femara®), exemestane (Aromasin®), goserelin (Zoladex®) and tamoxifen. </li> <li class="seamTextUnorderedListItem">Giving treatment before surgery--called neoadjuvant therapy--allows researchers to study how the cancer responds to the treatment.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02204098' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02204098?term=NCT02204098&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='https://source.wustl.edu/2014/12/breast-cancer-vaccine-shows-promise-in-small-clinical-trial/' target='_blank'>Washington University, St. Louis: Potential New Breast Cancer Vaccine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fredhutch.org/en/news/center-news/2014/12/breast-cancer-vaccine-shows-promise.html' target='_blank'>Fred Hutchinson Cancer Research Ctr: Mammaglobin-A DNA Vaccine</a> </li></ul>
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356

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: Visits every 3-6 months, up to 2 years

PHASE: II

NCT ID: NCT02476786

Hormone Therapy With or Without Other Treatment for Women 70 and Older With Low Risk Breast Cancer

Endocrine Treatment Alone as Primary Treatment for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score Scientific Title

Purpose
To study the effects (good and bad) of giving neoadjuvant hormone therapy to see if surgery (lumpectomy or mastectomy) can be avoided.
Who is this for?
Women 70 or older with stage I or stage II estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have not had surgery. Your tumor must be of a slow growing type that is at low risk for a recurrence.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doctor's choice of hormone therapy</li> <li class="seamTextUnorderedListItem">Office visit to assess your tumor, every 3 to 6 months, for up to 2 years</li> <li class="seamTextUnorderedListItem">Surgery, chemotherapy and/or radiation, if your tumor starts to grow or you want to have these treatments</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Oncotype DX test on tumor sample (biopsy)</li> <li class="seamTextUnorderedListItem">3 quality of life questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Your doctor will choose the hormone therapy drug you will receive: goserelin (Zoladex®), anastrozole (Arimidex®), letrozole (Femara®), exemestane (Aromasin®), fulvestrant (Faslodex®), or tamoxifen (Nolvadex®).</li> <li class="seamTextUnorderedListItem">You will not have surgery, radiation, or chemotherapy unless your tumor starts to grow or you decide you want to have these treatments.</li> <li class="seamTextUnorderedListItem">Ki67 is a protein found in cancer cells.</li> <li class="seamTextUnorderedListItem">By measuring the amount of the Ki67 protein in your cancer cells, researchers can learn how quickly the cancer cells are growing.</li> <li class="seamTextUnorderedListItem">To enroll in this study, researchers must determine that your cancer is slow growing.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02476786' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/diagnosis/rate_grade' target='_blank'>Breastcancer.org: Ki-67</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/testing/types/oncotype_dx' target='_blank'>Breastcancer.org: Oncotype DX Test</a> </li></ul>
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357

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: Visits 7 times over 1 year

PHASE: I

NCT ID: NCT03199040

Vaccine & Immunotherapy After Standard Care for Stage II-III Triple Negative Breast Cancer

A Randomized Phase 1 Trial of Neoantigen DNA Vaccine Alone vs. Neoantigen DNA Vaccine Plus Durvalumab in Triple Negative Breast Cancer Patients Following Standard of Care Therapy Scientific Title

Purpose
To study the effects (good and bad) of a personalized vaccine given alone or with an immunotherapy drug.
Who is this for?
Women newly diagnosed with stage II or stage III triple negative (ER-, PR-, HER2-) breast cancer who have already received standard of care therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care therapy</li> <li class="seamTextUnorderedListItem">followed by personalized vaccine, by injection, 6 times over 4 months (at least 3 weeks between each injection)</li> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by injection, monthly, starting at 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care therapy</li> <li class="seamTextUnorderedListItem">followed by personalized vaccine, by injection, 6 times over 4 months (at least 3 weeks between each injection )</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The personalized vaccine used in this study is a neoantigen DNA vaccine. </li> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®) is an immunotherapy drug that works by stimulating the body's immune system to go after cancer cells. It is approved to treat certain types of lung cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03199040' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nature.com/articles/d41586-017-08706-3' target='_blank'>Nature: Neoantiven Vaccines</a> </li></ul>
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358

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: 1 visit every 3 or 4 weeks, ongoing

PHASE: I

NCT ID: NCT03255070

ARX788 for HER2 Positive Advanced Breast Cancer

A Phase 1, Multicenter, Open-label, Multiple Dose-escalation Study of ARX788, Intravenously Administered as a Single Agent in Subjects With Advanced Cancers With HER2 Expression Scientific Title

Purpose
To evaluate the safety, effects (good and bad) and best dose of ARX788.
Who is this for?
People with HER2 positive advanced (some stage III) or metastatic (stage IV) breast cancer that has not responded to standard therapies and has already been treated with trastuzumab (Herceptin®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ARX788, by IV, every 3 or 4 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ARX788 is an antibody-drug conjugate (ADC). </li> <li class="seamTextUnorderedListItem">It uses an antibody that targets HER2 positive cancer cells to deliver a chemotherapy drug called amberstatin269 directly to these cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03255070' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://ambrx.com/pipeline/arx788-aher2-adc-oncology/' target='_blank'>Drug Company Information Page: ARX788 HER2 ADC</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-her2-antibody-drug-conjugate-arx788' target='_blank'>NCI Drug Dictionary: ARX788</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.hematologyandoncology.net/archives/april-2017/antibody-drug-conjugates-in-breast-cancer/' target='_blank'>Clinical Advances in Hematology & Oncology: ADC in Breast Cancer</a> </li></ul>
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359

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: At least 7 visits over 3 years

PHASE: II

NCT ID: NCT03862131

PROactive Evaluation to Reduce Treatment-Related Heart Problems (PROACT)

PROactive Evaluation of Function to Avoid CardioToxicity Scientific Title

Purpose
To look at whether MyoStrain® measurements are as good as or better than traditional MRI measurements for predicting and reducing a patient's risk of developing treatment-related heart problems.
Who is this for?
People with breast cancer and scheduled to start a cancer treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cardiac MRI at 1 month, 3 months, 6 months, 1 year, 2 years, and 3 years after the baseline visit</li> <li class="seamTextUnorderedListItem">MyoStrain® measurements</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cardiac MRI at 1 month, 3 months, 6 months, 1 year, 2 years, and 3 years after the baseline visit</li> <li class="seamTextUnorderedListItem">Standard of care MRI measurements (LVEF and LVEDV/LVESV)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MyoStrain® analyzes data collected from MRI heart scans to assess a patient's risk of developing heart problems.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03862131' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.myocardialsolutions.com/' target='_blank'>Sponsor site: MyoStrain®</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nccn.org/patients/resources/life_with_cancer/managing_symptoms/cardiac_toxicity.aspx' target='_blank'>National Comprehensive Cancer Network: Cardiac Toxicity</a> </li></ul>
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360

NEAREST SITE: 1739 miles
Washington University School Of Medicine
Saint Louis,MO

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04132817

Chemotherapy Plus One or Two Immunotherapies for Women With Advanced ER Positive, HER2 Negative Breast Cancer

A Phase 1 Multi-Targeted Study to Promote Anti-Tumor Immunity in ER Positive, HER2 Negative Advanced Breast Cancer Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of the chemotherapy nab-paclitaxel (Abraxane®) in combination with immunotherapy: either nivolumab (Opdivo®) or nivolumab and ipilimumab (Yervoy®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have received at least one but no more than three lines of treatment for advanced or metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, ongoing</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, ongoing</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, ongoing</li> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®), by IV, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®) is a type of immunotherapy called a PD-1 inhibitor.</li> <li class="seamTextUnorderedListItem">Ipilimumab (Yerovy®) is a type of immunotherapy called a CTLA-4 inhibitor.</li> <li class="seamTextUnorderedListItem">Neither immunotherapy drug is approved to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04132817' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.bmsstudyconnect.com/content/studyconnect/us/en/clinical-trials/NCT04132817.html?id=NCT04132817&location=New%20York,%20NY,%20USA&geo_lati=40.7127753&geo_long=-74.0059728' target='_blank'>Bristol-Meyers Squibb Study Information</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.opdivo.com' target='_blank'>Bristol-Meyers Squibb Drug Information Page: Opdivo® (Nivolumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.yervoy.com/metastatic/what-is-yervoy' target='_blank'>Bristol-Meyers Squibb Drug Information Page: Yervoy® (Ipilimumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nature.com/articles/s41598-019-57380-0' target='_blank'>Journal Article: Efficacy and safety of Nab-Paclitaxel</a> </li></ul>
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361

NEAREST SITE: 1754 miles
Cancer Care Specialists of Central Illinois-Swansea
Swansea,IL

VISITS: 1 visit every 3 weeks, for up to 2 years

PHASE: II

NCT ID: NCT04024800

AE37 Vaccine and Immunotherapy Pembrolizumab in Metastatic Triple Negative or ER-Low Breast Cancer

A Phase II Clinical Trial of Pembrolizumab in Combination With the AE37 Peptide Vaccine in Patients With Metastatic Triple-Negative Breast Cancer (NSABP FB-14) Scientific Title

Purpose
To study the safety, best dose and effects (good and bad) of an AE37 peptide vaccine (AE37) when it is given along with the PD-1 inhibitor pembrolizumab (Keytruda®).
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) who have been treated with at least one line of therapy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AE37 Peptide vaccine, by injection, once every 3 weeks, for 4 months</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda® ), by IV, once every 3 weeks, for up to 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">The vaccine is a type of immunotherapy. It gets the immune cells to see and kill cancer cells. </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor. It gets the immune system to see and kill cancer cells by blocking a checkpoint called PD-1. It is approved to treat metastatic breast tumors that genomic testing has shown are microsatellite instability-high (MSI-H) or have a DNA mismatch repair deficiency (dMMR).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04024800' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.targetedonc.com/news/pembrolizumab-and-chemotherapy-met-primary-endpoint-in-phase-iii-tnbc-trial' target='_blank'>Targeted Oncology: Pembrolizumab and Chemotherapy Met Primary Endpoint in Phase III TNBC Trial</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ae37-peptide-gm-csf-vaccine' target='_blank'>NCI Drug Dictionary: AE37 peptide</a> </li></ul>
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362

NEAREST SITE: 1816 miles
West Cancer Center
Germantown,TN

VISITS: Weekly visits for 4 months

PHASE: II

NCT ID: NCT03812393

Neratinib and Chemotherapy Before Surgery For Triple Negative Breast Cancer

Phase II Trial Evaluating the Efficacy and Safety of Neoadjuvant Neratinib and Chemotherapy in Early Stage Triple-Negative Breast Cancer Patients Who Exhibit Enhanced HER2 Signaling by Live Cell HER2 Signaling Transduction Analysis (FACT-2) Scientific Title

Purpose
To study the safety and effects (good and bad) of giving the anti-HER2 targeted therapy neratinib (Nerlynx®) along with paclitaxel (Taxol®) and carboplatin (Paraplatin®).
Who is this for?
People with stage I or stage II triple negative (ER-, PR-, HER2-) breast cancer that has abnormal HER2 signals based on the Celcuity CELx HER2 Signal Function (HSF) Test and who have not yet started treatment for your breast cancer.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Core needle biopsy to test for HER2 activity</li> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily, for 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily, for 3 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 months</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, weekly, for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®) is a HER2 targeted therapy used to treat early-stage, HER2-positive patients who have already been treated with trastuzumab (Herceptin®). </li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) and carboplatin (Paraplatin®) are chemotherapy drugs used to treat breast cancer.</li> <li class="seamTextUnorderedListItem">The Celcuity CELx HER2 Signal Function (HSF) Test examines HER2 activity in the tumor. </li> <li class="seamTextUnorderedListItem">Giving treatment before surgery allows researchers to study the effect the treatment has on cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03812393' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/nerlynx' target='_blank'>Breastcancer.org: Nerlynx</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancernetwork.com/breast-cancer/nab-paclitaxelcarboplatin-should-be-first-option-tnbc' target='_blank'>Cancer Network: Nab-Paclitaxel/Carboplatin Should Be a First Option in TNBC</a> </li></ul>
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363

NEAREST SITE: 1832 miles
Froedtert Hospital
Milwaukee,WI

VISITS: 5 visits over 10 days

PHASE: NA

NCT ID: NCT02728076

MRI-Guided Targeted Radiation Before Lumpectomy for ER+, Stage I-II Breast Cancer

Phase II Study of MRI-Based Preoperative Accelerated Partial Breast Irradiation Scientific Title

Purpose
To look at whether it is effective to use MRI with APBI to treat early-stage breast cancer.
Who is this for?
Women who have stage I or stage II estrogen receptor positive (ER+) breast cancer and who have not yet had surgery.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following 5-8 weeks before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation planning using MRI </li> <li class="seamTextUnorderedListItem">5 radiation treatments, every other day for 10 days</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by lumpectomy, chemotherapy and/or hormone therapy</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving radiation before surgery allows researchers to study how cancer cells respond to radiation treatments. </li> <li class="seamTextUnorderedListItem">Accelerated partial breast irradiation (APBI) is a type of radiation treatment that delivers a high dose of radiation directly to the tumor. </li> <li class="seamTextUnorderedListItem">This type of radiation treatment is less likely to damage healthy breast tissue. </li> <li class="seamTextUnorderedListItem">A CT (computed tomography) scan is typically used to plan the radiation treatment. </li> <li class="seamTextUnorderedListItem">Researchers think using MRI (magnetic resonance imaging) to plan the radiation treatment may lead to a better outcome.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02728076' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02728076' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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364

NEAREST SITE: 1843 miles
Northwestern University- Lake Forest Hospital
Lake Forest,IL

VISITS: 1 visit per month for 4 months, then every 2 weeks

PHASE: II

NCT ID: NCT02536794

Combination Immunotherapy in HER2-Negative Metastatic Breast Cancer

A Single Arm Phase II Study Evaluating the Efficacy and Safety of MEDI4736 in Combination With Tremelimumab in Patients With Metastatic Her2 Negative Breast Cancer Scientific Title

Purpose
To study the safety and effect (good and bad) of combining two immunotherapy drugs (MEDI4736 and tremelimumab).
Who is this for?
Women with HER2 negative metastatic breast cancer.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MEDI4736 and Tremelimumab, by IV, monthly for 4 months</li> <li class="seamTextUnorderedListItem">followed by MEDI4736, by IV, every 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MEDI4736 and tremelimumab are two new immunotherapy drugs currently being studied in clinical trials. </li> <li class="seamTextUnorderedListItem">MEDI4736 targets the programmed cell death 1 (PD-1)/B7H1 protein. </li> <li class="seamTextUnorderedListItem">Tremelimumab targets the CTLA4 protein.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02536794' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02536794?term=NCT02536794&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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365

NEAREST SITE: 1853 miles
Rush University Cancer Center
Chicago,IL

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03544723

Gene Therapy Ad-p53 In Combination With Immunotherapy for Advanced Breast Cancer

A Phase 2, Multi-Center, Open Label Study to Evaluate Efficacy and Safety of Adenoviral p53 (Ad-p53) in Combination With Immune Checkpoint Inhibitor Therapy in Patients With Progression or Recurrence of Head and Neck Squamous Cell Carcinoma (HNSCC) Scientific Title

Purpose
To study the safety and anti-cancer activity of giving the gene therapy Ad-p53 in combination with a PD-1 or PD-L1 inhibitor.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ad-p53, by injection, directly into your tumor</li> <li class="seamTextUnorderedListItem">Doctor's choice of PD-1 inhibitor or PD-L1 inhibitor, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ad-p53 is a type of gene therapy.</li> <li class="seamTextUnorderedListItem">Gene therapy is a treatment that inserts genetic material (DNA or RNA) directly into your cells to prevent or fight disease.</li> <li class="seamTextUnorderedListItem">PD-1 inhibitors are a type of immunotherapy called a checkpoint inhibitor. They get the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). </li> <li class="seamTextUnorderedListItem">PD-L1 inhibitors are also checkpoint inhibitors. They stimulate your immune system to go after cancer cells by blocking a protein called PD-L1 (programmed death-ligand 1).</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced and metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03544723' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ad5cmv-p53-gene' target='_blank'>NCI Drug Dictionary: Ad-p53</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertodaymag.org/Pages/cancer-talk/First-Immunotherapy-Approved-for-Breast-Cancer.aspx' target='_blank'>Cancer Today: First Immunotherapy Approved for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors' target='_blank'>Wikipedia: PD-1 and PD-L1 inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/gene-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Gene Therapy</a> </li></ul>
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366

NEAREST SITE: 1853 miles
University of Illinois
Chicago,IL

VISITS: Weekly visits for 3 months, then every other week for 2 months

PHASE: II

NCT ID: NCT04083963

Carboplatin & Standard Chemotherapy Before Surgery in Triple Negative Breast Cancer

BRE-01: Phase 2 Trial of Neoadjuvant Weekly Carboplatin Plus Paclitaxel Followed by Doxorubicin and Cyclophosphamide in Triple Negative Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of adding a low dose of the chemotherapy drug paraplatin (Carboplatin®) to the standard of care neoadjuvant chemotherapy regimen for triple negative tumors.
Who is this for?
Women with early-stage (stage II and some stage IIII) triple negative (ER-, PR- and HER2-) breast cancer who have not yet started cancer treatment and is expected to have breast cancer surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following treatment before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paraplatin (Carboplatin®), by IV, weekly, for 3 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 months</li> <li class="seamTextUnorderedListItem">Doxorubicin (Doxil®), by IV, every other week, for 2 months</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®), by IV, every other week, for 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The standard of care regimen includes these three chemotherapy drugs: paclitaxel (Taxol®), doxorubicin (Doxil®), and cyclophosphamide (Cytoxan®). </li> <li class="seamTextUnorderedListItem">All of the chemotherapy drugs being used in this study are approved to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04083963' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healio.com/hematology-oncology/breast-cancer/news/print/hemonc-today/%7B4f8936d7-fa9f-443b-8b46-3b5056efceb4%7D/should-neoadjuvant-carboplatin-be-used-for-triple-negative-breast-cancer' target='_blank'>Healio: Should neoadjuvant carboplatin be used for TNBC?</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.516' target='_blank'>ASCo 2019: Results of randomized phase II trial of neoadjuvant carboplatin plus docetaxel or carboplatin plus paclitaxel followed by AC in stage I-III TNBC (NCT02413320).</a> </li></ul>
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367

NEAREST SITE: 1856 miles
Northwestern University
Chicago,IL

VISITS: 1 visit every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03213041

Keytruda with Chemotherapy for Treating HER2- Metastatic Breast Cancer

I-CURE-1: A Phase II, Single Arm Study of Pembroluzimab Combined With Carboplatin in Patients With Circulating Tumor Cells (CTCs) Positive Her-2 Negative Metastatic Breast Cancer (MBC) Scientific Title

Purpose
To determine the safety and effects (good and bad) of treating HER2-negative metastatic breast cancer with an immunotherapy drug along with a chemotherapy drug.
Who is this for?
People with metastatic (stage IV) breast cancer that is HER2 negative. If you are estrogen receptor positive, you must have progressed on available endocrine therapy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks for up to 2 years</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks for up to 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy drug used in this study is pembrolizumab (Keytruda®). It is a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">The chemotherapy drug is carboplatin (Paraplatin®). It is used to treat metastatic breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03213041' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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368

NEAREST SITE: 1857 miles
University of Chicago
Chicago,IL

VISITS: 1 visit a week, ongoing

PHASE: II

NCT ID: NCT02788981

Abraxane & Mifepristone in Advanced Triple Negative or ER-Low Breast Cancer that is Glucocorticoid Receptor Positive

A Randomized, Placebo-Controlled, Double-Blind, Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel (Nab-Paclitaxel, Abraxane®) With or Without Mifepristone for Advanced, Glucocorticoid Receptor-Positive, Triple-Negative Breast Cancer Scientific Title

Purpose
To determine the safety and effects (good and bad) of using chemotherapy in combination with the anti-progesterone therapy mifepristone.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- HER2-) or ER-Low (1%-10% ER) breast cancer that tests positive for glucocorticoid receptors.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mifepristone, by mouth, daily</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, weekly (3 weeks on, 1 week off)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, weekly (3 weeks on, 1 week off)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">The chemotherapy drug being used in this study is nab-paclitaxel (Abraxane®). It is approved to treat advanced breast cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: glucocorticoid receptors</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02788981' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860283/' target='_blank'>Clinical Cancer Research: Glucocorticoid receptor antagonism for TNBC</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.abraxanepro.com' target='_blank'>Drug Company Information Page: Abraxane</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Mifepristone' target='_blank'>Wikipedia: Mifepristone</a> </li></ul>
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369

NEAREST SITE: 1857 miles
University of Chicago
Chicago,IL

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I

NCT ID: NCT03135171

Two Targeted Therapies with Tocilizumab for HER2+ Metastatic Breast Cancer Resistant to Herceptin

A Phase 1 Multi-Center Trial of Trastuzumab and Pertuzumab in Combination With Tocilizumab in Subjects With Metastatic HER2 Positive Breast Cancer Resistant to Trastuzumab Scientific Title

Purpose
To study the safety and effects (good and bad) of using three targeted drugs to treat HER2-positive metastatic breast cancer that has stopped responding to Herceptin.
Who is this for?
People with HER2 positive metastatic (stage IV) breast cancer. You must have already been treated with trastuzumab (Herceptin).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Tocilizumab (Actemra®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The three drug combination is HER2-targeted drugs (Herceptin and pertuzumab (Perjeta®)) and tocilizumab (Actemra®). </li> <li class="seamTextUnorderedListItem">Actemra is a targeted drug approved to treat rheumatoid arthritis</li> <li class="seamTextUnorderedListItem">Laboratory studies suggest Actemra may get HER2+ tumors to start responding again to Herceptin.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03135171' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Tocilizumab-Actemra' target='_blank'>Tocilizumab</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/targeted_therapies' target='_blank'>Breastcancer.org: Herceptin and Perjeta</a> </li></ul>
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370

NEAREST SITE: 1857 miles
University of Chicago
Chicago,IL

VISITS: 1 visit

PHASE: NA

NCT ID: NCT03238976

Nature Sounds to Reduce Pain and Anxiety During a Breast Core Needle Biopsy

Nature Sounds as a Pain and Anxiety Reducing Strategy in Patients Undergoing Breast Core Biopsy: A Randomized Study Scientific Title

Purpose
To investigate the effects (good and bad) playing continuous nature sounds during a core needle biopsy has on a patient's pain and anxiety.
Who is this for?
Women scheduled to have a breast core needle biopsy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Receive continuous nature sounds during core needle biopsy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Receive supportive dialogue during core needle biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A core needle biopsy is a procedure that removes a small amount of suspicious tissue from the breast with a needle.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03238976' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/CoreNeedleBiopsy.html' target='_blank'>Susan G. Komen: Core Needle Biopsy</a> </li></ul>
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371

NEAREST SITE: 1857 miles
University of Chicago
Chicago,IL

VISITS: Visits every 3 weeks, for 6 months

PHASE: II

NCT ID: NCT03487666

Opdivo plus Xeloda After Surgery for Triple Negative Breast Cancer

OXEL: A Pilot Study of Immune Checkpoint or Capecitabine or Combination Therapy as Adjuvant Therapy for Triple Negative Breast Cancer With Residual Disease Following Neoadjuvant Chemotherapy Scientific Title

Purpose
To compare the effects (good and bad) of using two drugs alone or together after surgery.
Who is this for?
People with triple negative (ER-, PR-, and HER2-), DCIS, LCIS, or early stage (stage I, stage II or stage III) breast cancer that was treated with chemotherapy before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks, for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, daily, for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks, for 6 months</li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, daily, for 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two drugs being used in this study are nivolumab (Opdivo®) and capecitabine (Xeloda®).</li> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy drug called a PD-1 inhibitor. It is approved to treat certain types of metastatic melanoma and non-small cell lung cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Xeloda is a chemotherapy drug used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03487666' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy/what' target='_blank'>Breastcancer.org: What is Immunotherapy?</a> </li></ul>
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372

NEAREST SITE: 1906 miles
USA02
Lafayette,IN

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT04444427

GLR2007 for Metastatic Breast Cancer that has Spread to the Brain

An Open-Label, Multicenter, Phase 1b/2 Study to Establish Safety, Tolerability, and Optimal Dosing Strategy of GLR2007 in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To study the safety, side effects, and best dose of the experimental targeted therapy GLR2007.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the brain and who have already received a CDK 4/6 inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GLR2007, by mouth, daily (3 weeks on, 1 week off), ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain MRI</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GLR2007 is a type targeted therapy called a cyclin-dependent kinase 4/6 inhibitor (CDK 4/6 inhibitor). </li> <li class="seamTextUnorderedListItem">Experimental therapies are only available in clinical trials.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04444427' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biospace.com/article/releases/gan-and-amp-lee-pharmaceuticals-initiates-first-in-human-phase-1-clinical-trial-for-new-anti-tumor-drug-glr2007/' target='_blank'>BioSpace Press Release: GLR2007</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nature.com/articles/s41523-019-0121-y' target='_blank'>Journal Article: Are all cyclin-dependent kinases 4/6 inhibitors created equal?</a> </li></ul>
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373

NEAREST SITE: 1933 miles
I U Health West
Avon,IN

VISITS: 15 visits over 3 weeks plus chemotherapy

PHASE: I

NCT ID: NCT01618357

Radiation and Veliparib After Chemotherapy and Before Surgery

Pre-Operative PARPi and Irradiation (POPI) in Women With an Incomplete Response to Neo-Adjuvant Chemotherapy for Breast Cancer Scientific Title

Purpose
To investigate the safety of combining radiation and Veliparib.
Who is this for?
Women with stage IIb, stage III, or metastatic (stage IV) breast cancer whose cancer did not have a complete response to neoadjuvant chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neoadjuvant chemotherapy (at the discretion of the oncologist)</li> </ul> <p class="seamTextPara"> Participants with an incomplete response following chemotherapy will receive the following treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation, Monday-Friday, for 3 weeks</li> <li class="seamTextUnorderedListItem">Veliparib by mouth twice daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving chemotherapy before surgery (called neoadjuvant therapy) allows doctors to see how the tumor responds to the treatment.</li> <li class="seamTextUnorderedListItem">It can also shrink the tumor, which may permit a woman to have a lumpectomy instead of a mastectomy.</li> <li class="seamTextUnorderedListItem">About 20-30 percent of the time, the breast tumor will completely disappear. This is referred to as a pathologic complete response (PCR).</li> <li class="seamTextUnorderedListItem">Studies that have looked at whether giving radiation before surgery will increase the PCR rate have had mixed results.</li> <li class="seamTextUnorderedListItem">Veliparib is a type of new cancer treatment called a PARP inhibitor. Laboratory studies have shown that it can make the tumor more likely to respond to radiation and chemotherapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01618357' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT01618357' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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374

NEAREST SITE: 1941 miles
Animated Dynamics, Inc.
Indianapolis,IN

VISITS: At least 1-2 visits

PHASE: NA

NCT ID: NCT03164863

Onco 4D® Chemotherapy Selection for Women with Breast Cancer or Abnormal Imaging Results

Feasibility Study of Motility Contrast Tomography for Predicting Therapeutic Response Scientific Title

Purpose
To see if a new technology called Onco 4D® can help predict how breast cancer will respond to chemotherapy.
Who is this for?
Women recently diagnosed with breast cancer or had an abnormal mammography/ultrasound or an abnormal clinical exam. You must have not yet have had surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 or 2 biopsies</li> <li class="seamTextUnorderedListItem">Your biopsy sample will be evaluated using motility contrast tomography (MTC)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Onco 4D uses motility contrast tomography, a new type of imaging, to determine how your cancer is likely to respond to different types of chemotherapy. </li> <li class="seamTextUnorderedListItem">The Onco 4D test will be done after you have had a mammogram or ultrasound but before you have a biopsy.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03164863' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.purdue.edu/newsroom/releases/2016/Q2/closing-of-series-a-funding-to-help-purdue-biotech-company-improve-targeted-cancer-treatments.html' target='_blank'>Purdue.edu: Onco 4D™</a> </li></ul>
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375

NEAREST SITE: 1946 miles
Indiana University
Indianapolis,IN

VISITS: 1 visit a week, ongoing

PHASE: II

NCT ID: NCT02755272

Keytruda with Chemotherapy for Metastatic Triple Negative or ER-Low Breast Cancer

A Randomized Phase II Clinical Trial Assessing the Efficacy and Safety of MK-3475 (Pembrolizumab) in Combination With Carboplatin and Gemcitabine in Patients With Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To study the anti-cancer activity of giving the PD-1 inhibitor pembrolizumab (Keytruda®) immunotherapy in combination with chemotherapy.
Who is this for?
Women with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10%) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) and gemcitabine (Gemzar®) by IV, once a week, 2 weeks on 1 week off</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) and gemcitabine (Gemzar®) by IV, once a week, 2 weeks on 1 week off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking PD-1.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02755272' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=CjwKCAjwy7vlBRACEiwAZvdx9jIPFQgWidLA-C5wT1MzjtITa1lJzO4axMQhgd1rro0RP5g40-abvxoCQlYQA' target='_blank'>Merck Information Page: Keytruda</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/EmergingMetasticBreastCancer.html' target='_blank'>Susan G. Komen: Emerging Areas in Metastatic Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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376

NEAREST SITE: 1946 miles
Indiana University Health Melvin Bren Simon Cancer Center
Indianapolis,IN

VISITS: 1 visit every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03206203

Carboplatin plus Atezolizumab for Metastatic Triple Negative or ER-Low Breast Cancer

A Phase II Trial of Atezolizumab (Anti-PDL1) With Carboplatin in Patients With Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To compare the anti-cancer activity of giving the chemotherapy carboplatin (Paraplatin®) alone to giving it in combination with the immunotherapy atezolizumab (Tecentriq®).
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer. You must not have received more than one prior chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®) is the chemotherapy drug used in this study. </li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is the immunotherapy drug used in this study. It is an anti-PDL1 medicine.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03206203' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tecentriq.com' target='_blank'>Genentech Information Page: Atezolizumab</a> </li></ul>
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377

NEAREST SITE: 1946 miles
IU Simon Cancer Center
Indianapolis,IN

VISITS: Weekly visits, ongoing

PHASE: I

NCT ID: NCT03243331

Gedatolisib plus PTK7-ADC for Metastatic Triple Negative Breast Cancer

An Initial Safety Study of Gedatolisib Plus PTK7-ADC for Metastatic Triple-negative Breast Cancer Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using two investigational drugs to treat metastatic triple negative breast cancer.
Who is this for?
People with metastatic (stage IV) breast cancer that is triple negative. You must have received at least 1 prior chemotherapy regimen for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gedatolisib, by IV, weekly (3 weeks on, 1 week off), ongoing </li> <li class="seamTextUnorderedListItem">PTK7-ADC (PF-06647020), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two drugs are gedatolisib and PTK7-ADC. </li> <li class="seamTextUnorderedListItem">Gedatolisib is a targeted therapy that works by blocking PI3K and mTOR kinase proteins, which play a role in the cellular pathways that help tumors grow. </li> <li class="seamTextUnorderedListItem">PTK7-ADC (PF-06647020) targets a protein called PTK7, which is often found on cancer cells. </li> <li class="seamTextUnorderedListItem">It is an antibody-drug conjugate (ADC). This means it uses an antibody that targets cancer cells to deliver a drug that can kill these cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03243331' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pfizer.com/files/news/asco/Pfizer_IO_GetaPI3KFactSheet.pdf' target='_blank'>Pfizer: Gedatolisib</a> </li></ul>
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378

NEAREST SITE: 1946 miles
Indiana University Melvin & Bren Simon Cancer Center
Indianapolis,IN

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04134884

ASTX727 and Talazoparib in Advanced HER2 Negative Breast Cancer

A Phase I Study of ASTX727 Plus Talazoparib in Patients With Triple Negative or Hormone Resistant/ Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Metastatic Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of using the PARP inhibitor Talazoparib (Talzenna®) along with the targeted therapy ASTX727.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer who have already received chemotherapy or a CDK 4/6 inhibitor with hormone therapy for metastatic disease.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">ASTX727, by mouth, first 5 days of every cycle (28 days), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®) is a type of drug called a PARP inhibitor. It works by preventing the PARP protein from repairing damaged DNA in tumor cells.</li> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®) is approved to treat advanced or metastatic HER2 negative (HER2-) breast cancer in people with an inherited BRCA 1 or BRCA 2 mutation.</li> <li class="seamTextUnorderedListItem">ASTX727 is an investigational targeted therapy that is only available in clinical trials.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04134884' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/talzenna' target='_blank'>Breastcancer.org: Talazoparib (Talzenna®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.talzenna.com/?source=google&HBX_PK=s_+pfizer++talazoparib&skwid=43700051780428716' target='_blank'>Pfizer Oncology Drug Information Page: Talzenna® (Talazoparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/expertconnections/parp-inhibition-brca-mutated-breast-cancer/benefit-of-parp-inhibitors-in-brca-positive-breast-cancer' target='_blank'>Cure Today: Benefit of PARP Inhibitors in BRCA+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/cda-inhibitor-e7727-decitabine-combination-agent-astx727' target='_blank'>NCI Drug Dictionary: ASTX727 (CDA Inhibitor E7727)</a> </li><li class='seamTextUnorderedListItem'><a href='https://astx.com/research-development/clinical-pipeline/astx727-oral-dnmt-inhibitor-hematological-malignancies/' target='_blank'>Drug Company Information Page: ASTX727 (Cedazuridine and Decitabine)</a> </li></ul>
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379

NEAREST SITE: 1946 miles
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
Indianapolis,IN

VISITS: 3 to 8 visits a month, ongoing

PHASE: II

NCT ID: NCT04215146

Pelareorep with Taxol or with Taxol & Avelumab for Advanced HR+, HER2- Breast Cancer

A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study Scientific Title

Purpose
To study the safety and anti-cancer activity of the experimental immunotherapy pelareorep when it is given in combination with paclitaxel (Taxol®) or with paclitaxel (Taxol®) and the PD-L1 inhibitor avelumab (Bavencio®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer whose disease progressed after they received a CDK 4/6 inhibitor in combination with hormone therapy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off), ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Pelareorep, by IV, 2 days a week (3 weeks on, 1 week off), ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Pelareorep, by IV, 2 days a week (3 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, every 2 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy used for advanced breast cancer.</li> <li class="seamTextUnorderedListItem">Avelumab (Bevancio®) is an immunotherapy that works by stimulating the body's immune system to go after cancer cells by blocking a protein called PD-L1.</li> <li class="seamTextUnorderedListItem">Pelareorep is an oncolytic virus--this means it targets and kills cancer cells. It may directly kill cancer cells and stimulate your immune system to go after and kill cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04215146' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Pelareorep' target='_blank'>Wikipedia: Pelareorep</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Avelumab' target='_blank'>Wikipedia: Avelumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/paclitaxel-taxol' target='_blank'>Breast Cancer Now: Paclitaxel</a> </li></ul>
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380

NEAREST SITE: 1958 miles
Vanderbilt University/Ingram Cancer Center
Nashville,TN

VISITS: Visits weekly, ongoing

PHASE: I

NCT ID: NCT02672475

Galunisertib and Taxol for Metastatic Triple Negative Breast Cancer

A Phase Ib Trial of LY2157299 (TGFβR1 Kinase Inhibitor) With Paclitaxel in Patients With Triple Negative Metastatic Breast Cancer Scientific Title

Purpose
To evaluate the best dose and safety of galunisertib and Taxol for treating patients with metastatic triple negative breast cancer that is also androgen-receptor negative.
Who is this for?
People diagnosed with metastatic (stage IV) triple negative breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, 3 weeks on, 1 week off</li> <li class="seamTextUnorderedListItem">Galunisertib (LY2157299), by mouth, twice daily, 3 weeks on, 1 week off</li></ul>
  • <p class="seamTextPara"> Paclitaxel (Taxol®) is a chemotherapy drug routinely used to treat advanced breast cancer. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Galunisertib (LY2157299) is a new type of targeted therapy. It works by blocking a protein called TGF-beta 1 kinase.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02672475' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02672475?term=NCT02672475&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/publications/oncology-live/2014/august-2014/targeting-the-androgen-receptor-new-hope-for-aggressive-forms-of-prostate-and-breast-cancer/3' target='_blank'>OncLive: Targeting Angrogen Receptor</a> </li></ul>
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381

NEAREST SITE: 1958 miles
Vanderbilt-Ingram Cancer Center
Nashville,TN

VISITS: At least 1 visit per month, ongoing

PHASE: I

NCT ID: NCT03238196

Faslodex, Ibrance & Erdafitinib for ER+, HER2-, Advanced Breast Cancer

A Phase Ib Trial of Fulvestrant, Palbociclib (CDK4/6 Inhibitor) and Erdafitinib (JNJ- 42756493,Pan-FGFR Tyrosine Kinase Inhibitor) in ER+/HER2-/FGFR-Amplified Metastatic Breast Cancer (MBC) Scientific Title

Purpose
To investigate the best dose, safety and effects (good and bad) of giving targeted therapies along with hormone therapy.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who are estrogen receptor positive and HER2 negative. As part of the study, your tumor will be tested to see if it is FGFR positive.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, once a month, ongoing </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off), ongoing </li> <li class="seamTextUnorderedListItem">Erdafitinib (JNJ-42756493), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a type of targeted therapy called a CDK4/6 inhibitor. </li> <li class="seamTextUnorderedListItem">Erdafitinib (JNJ-42756493) is an experimental targeted therapy that works by targeting the FGFR tyrosine kinase protein. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is the hormone therapy used in this study. It is approved to treat metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">Targets or mutations: FGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03238196' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Erdafitinib' target='_blank'>Wikipedia: Erdafitinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/erds/faslodex' target='_blank'>Breastcancer.org: Faslodex</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com/?src_code=IBRW10028851' target='_blank'>Pfizer Oncology Information Page: Ibrance</a> </li></ul>
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382

NEAREST SITE: 1958 miles
Vanderbilt-Ingram Cancer Center
Nashville,TN

VISITS: Visits 5 days a week for 6 weeks

PHASE: I

NCT ID: NCT03958721

Capecitabine & Radiation for Tumors That Did Not Fully Respond to Chemo Before Surgery

Concurrent Capecitabine and Radiotherapy in the Adjuvant Treatment of Resistant Breast Cancer: A Prospective Feasibility Trial Scientific Title

Purpose
To study the effects (good and bad) of using capecitabine (Xeloda®) and radiation after surgery following neoadjuvant chemotherapy (chemo given before surgery).
Who is this for?
Women with stage II or stage III breast cancer whose tumor did not fully respond to chemotherapy given before surgery and who were not treated with capecitabine or 5-FU.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, twice daily, every other week, for 6 weeks</li> <li class="seamTextUnorderedListItem">Radiotherapy, once daily (Monday through Friday), for 6 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Xeloda® is a chemotherapy drug approved to treat metastatic breast cancer. Its use in early-stage breast cancer is considered investigational.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03958721' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/xeloda-improves-survival-for-some' target='_blank'>Breastcancer.org: Treating Residual Disease With Xeloda Improves Survival in Women With Early-Stage, HER2-Negative Disease</a> </li></ul>
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383

NEAREST SITE: 1958 miles
Vanderbilt-Ingram Cancer Center
Nashville,TN

VISITS: Number of visits unavailable, over 2 weeks

PHASE: NA

NCT ID: NCT03962647

Keto Diet and Letrozole Before Surgery in Women with Stage I-III, ER+, HER2- Breast Cancer with a BMI >=30

A Pilot and Feasibility Neoadjuvant Study of a 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+ Breast Cancer Scientific Title

Purpose
To study the effects the ketogenic, or keto, diet has on breast cancer cells in patients who are taking the anti-estrogen drug letrozole (Femara®) before surgery.
Who is this for?
Postmenopausal women with stage I, stage II, or stage III estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have a BMI >=30.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Before surgery, you will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily, for 2 weeks</li> <li class="seamTextUnorderedListItem">Ketogenic meal replacement shakes, for 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The keto diet is typically high in fat and low in carbohydrates. </li> <li class="seamTextUnorderedListItem">In this study, you will be given meal replacement shakes that mimic a keto diet. </li> <li class="seamTextUnorderedListItem">The keto diet affects the amount of glucose in the body. Reducing glucose may affect how quickly cancer cells grow.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03962647' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fredhutch.org/en/news/center-news/2019/10/keto-fat-cancer-its-complicated.html' target='_blank'>Fred Hutchinson Cancer Research Center: Keto, Fat and Cancer, It's Complicated</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors/femara' target='_blank'>Breastcancer.org: Letrozole</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.vanderbiltcancer.org/clinical-trials/protocol-viccbre18108' target='_blank'>Vanderbilt-Ingram Cancer Center: Study page</a> </li></ul>
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384

NEAREST SITE: 1959 miles
Sarah Cannon Research Institute
Nashville,TN

VISITS: 1-2 visits over 4 weeks, ongoing

PHASE: I

NCT ID: NCT03006172

GDC-0077 & Anti-Estrogen Therapy with or without Palbociclib for Advanced Breast Cancer with a PIK3CA Mutation

A Phase I, Open-Label, Dose-Escalation Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0077 as a Single Agent in Patients With Locally Advanced or Metastatic PIK3CA-Mutant Solid Tumors and in Combination With Endocrine and Targeted Therapies in Patients With Locally Advanced or Metastatic PIK3CA-Mutant... Scientific Title

Purpose
To study the safety and effects (good and bad) of the experimental drug GDC-0077 when it is used in breast cancer that has a PIK3CA mutation.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer. You will only be eligible for this study if your tumor has a PIK3CA mutation. The study investigator will test your tumor for this mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0077, by mouth daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0077, by mouth daily, ongoing</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0077, by mouth daily, ongoing</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0077, by mouth daily, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 1-2 times over 4 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is an approved CDK 4/6 inhibitor. </li> <li class="seamTextUnorderedListItem">Letrozole (Femara®) and fulvestrant (Faslodex®) are approved anti-estrogen drugs. </li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03006172' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/clinical-trials/16-1556' target='_blank'>Memorial Sloan Kettering Cancer Center: Study website</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Palbociclib' target='_blank'>Wikipedia: Palbociclib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com/?src_code=IBRW10028851' target='_blank'>Pfizer Oncology Information Page: Ibrance</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/4_Supplement/PD4-14' target='_blank'>AACR Abstract: GDC-0077</a> </li></ul>
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385

NEAREST SITE: 1959 miles
Novartis Investigative Site
Nashville,TN

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03742349

Four Immunotherapy Combinations in Advanced Triple Negative Breast Cancer

A Phase Ib, Multicenter, Open-label Dose Escalation and Expansion Platform Study of Select Immunotherapy Combinations in Adult Patients With Triple-negative Breast Cancer Scientific Title

Purpose
To study the safety, best dose and effects (good and bad) of spartalizumab and LAG525 when they are used in combination with NIR178, capmatinib, MCS110, or canakinumab.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have not received more than two prior lines of chemotherapy, including neoadjuvant or adjuvant chemotherapy; and have had a taxane-based chemotherapy as neoadjuvant or metastatic treatment.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Spartalizumab (PDR001), by IV</li> <li class="seamTextUnorderedListItem">LAG525, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">with 1 of the following 4 drugs: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NIR178, by mouth</li> <li class="seamTextUnorderedListItem">Capmatinib (INC280), by mouth</li> <li class="seamTextUnorderedListItem">MCS110 (INC280), by IV</li> <li class="seamTextUnorderedListItem">Canakinumab (ACZ885), by injection</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Spartalizumab is an investigational PD-1 immune checkpoint inhibitor. </li> <li class="seamTextUnorderedListItem">LAG525 is an investigational immune checkpoint inhibitor that targets LAG-3. </li> <li class="seamTextUnorderedListItem">NIR178 is an investigational immunotherapy. </li> <li class="seamTextUnorderedListItem">Capmatinib is a targeted therapy that blocks c-Met, which plays a role in cancer cell growth.</li> <li class="seamTextUnorderedListItem">MCS110 is an investigational immunotherapy that targets M-CSF. </li> <li class="seamTextUnorderedListItem">Canakinumab is an investigational monoclonal antibody that targets human interleukin-1 beta (IL-1b), which plays a role in inflammation.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03742349' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/spartalizumab' target='_blank'>NCI Drug Dictionary: Spartalizumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-lag-3-monoclonal-antibody-lag525' target='_blank'>NCI Drug Dictionary: LAG525</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/capmatinib' target='_blank'>NCI Drug Dictionary: Capmatinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-m-csf-monoclonal-antibody-mcs110' target='_blank'>NCI Drug Dictionary: MCS110</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/795723' target='_blank'>NCI Drug Dictionary: Canakinumab</a> </li></ul>
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386

NEAREST SITE: 1959 miles
Sarah Cannon Research Institute Drug Ship - 3
Nashville,TN

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03891953

Immunotherapy DKY709 Alone or With PDR001 in Advanced Triple Negative Breast Cancer

A Phase I/Ib, Open-label, Multi-center, Study of DKY709 as a Single Agent and in Combination With PDR001 in Patients With Advanced Solid Tumors Scientific Title

Purpose
To compare the safety and effects (good and bad) of DKY709 alone and in combination with PDR001.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer that has not been treated with a PD-1 or PD-L1 checkpoint inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DKY709</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DKY709</li> <li class="seamTextUnorderedListItem">PDR001 (Spartalizumab)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">DKY709 is an investigational immunotherapy. </li> <li class="seamTextUnorderedListItem">PDR001 (spartalizumab) is an investigational immunotherapy that targets PD-1 .</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03891953' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/spartalizumab' target='_blank'>NCI Drug Dictionary: Spartalizumab</a> </li></ul>
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387

NEAREST SITE: 1959 miles
Sarah Cannon Research Institute
Nashville,TN

VISITS: 1 visit every 3 weeks

PHASE: I

NCT ID: NCT04157517

Immunotherapy TAK-573 for Advanced Triple Negative Breast Cancer

An Open-Label, Dose-Escalation Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-573 in Adult Patients With Metastatic Solid Tumors Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of the immunotherapy TAK-573.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TAK-573, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TAK-573 is an experimental immunotherapy. This means it is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04157517' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cd38-targeted-igg4-attenuated-ifna-tak-573' target='_blank'>NCI Drug Dictionary: TAK-573</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.takeda.com/49ef0c/siteassets/system/investors/report/quarterlyannouncements/fy2018/1_oncology_e.pdf' target='_blank'>Takeda Drug Information Page: TAK-573</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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388

NEAREST SITE: 1984 miles
James Graham Brown Cancer Center at the University of Louisville
Louisville,KY

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT04088435

Radiation During Surgery in Stage I or Stage II ER Positive Breast Cancer

A Prospective Observational Trial of Xoft® Intraoperative Radiotherapy (IORT) as a Component of Breast Conserving Therapy (BCT) in Patients With Early-Stage Breast Cancer Scientific Title

Purpose
To look at the safety and effects (good and bad) of using intraoperative radiotherapy (IORT).
Who is this for?
People with stage I or stage II ER positive and HER2 negative breast cancer and be planning to have a lumpectomy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiotherapy during surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Post-treatment follow-up</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Follow-up visits at 4-6 weeks, 6 months, 1 year, 18 months, 2 years and then yearly for a total of 5 years</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">IORT radiation therapy is delivered as a single treatment during surgery. This study is using an IORT device called Xoft®.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04088435' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.xoftinc.com/breast-ebx-iort-apbi.html' target='_blank'>Sponsor site: Intraoperative Radiation Therapy</a> </li></ul>
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389

NEAREST SITE: 2010 miles
University of Alabama at Birmingham (UAB) Hazelrig-Salter Radiation Oncology Center (HSROC)
Birmingham,AL

VISITS: 5 visits

PHASE: NA

NCT ID: NCT03643861

Stereotactic Radiation For Patients Age 50+ with ER+ DCIS or Stage I - II Breast Cancer

RAD 1802: Pilot Trial of LINAC Based Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI) Scientific Title

Purpose
To study the safety, side effects and effectiveness of stereotactic body radiation therapy (SBRT).
Who is this for?
People with DCIS, stage I or stage IIA estrogen receptor positive (ER+) breast cancer who are over age 50, have had a lumpectomy, and have not had chemotherapy before surgery.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> You will receive the following after breast surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast stereotactic body radiation therapy, 5 sessions</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic body radiation therapy (SBRT) delivers a higher targeted dose of radiation in fewer sessions than standard radiation therapy.</li> <li class="seamTextUnorderedListItem">In this study, you will have 5 sessions. </li> <li class="seamTextUnorderedListItem">The higher dose can be targeted in a way that reduces risk to nearby normal tissue or organs.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03643861' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/treatment-options/stereotactic-body-radiation-therapy.html' target='_blank'>MD Anderson Cancer Center: Stereotactic Body Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-approves-stereotactic-radiotherapy-system-for-breast-cancer' target='_blank'>OncLive: FDA Approves Stereotactic Radiotherapy System for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.uclahealth.org/radonc/faqs-sbrt' target='_blank'>UCLA Health: FAQs: SBRT</a> </li></ul>
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390

NEAREST SITE: 2010 miles
Research Site
Birmingham,AL

VISITS: At least once a month

PHASE: II

NCT ID: NCT04214288

AZD9833 or Fulvestrant For Women With Advanced ER+, HER2- Breast Cancer

SERENA-2: A Randomised, Open-Label, Parallel-Group, Multicentre Phase 2 Study Comparing the Efficacy and Safety of Oral AZD9833 Versus Fulvestrant in Women With Advanced ER-Positive HER2-Negative Breast Cancer Scientific Title

Purpose
To compare the safety and anti-cancer activity of different doses of AZD9833, an experimental anti-estrogen drug that is take by mouth, to fulvestrant (Faslodex®), a commonly used anti-estrogen drug that is given by injection.
Who is this for?
Postmenopausal women with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer. You must not have received more than one chemotherapy and one anti-hormone therapy for advance disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD9833, by mouth, daily, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) by injection, once a month, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is an anti-estrogen drug approved to treat postmenopausal women with metastatic, hormone positive (ER+ and/or PR+) breast cancer. </li> <li class="seamTextUnorderedListItem">AZD9833 is an experimental anti-estrogen drug. This means it is only available in a clinical trial.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04214288' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/RecommendedTreatmentsforMetastaticBreastCancer.html' target='_blank'>Susan G. Komen: Recommended Treatments for Metastatic Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/799429' target='_blank'>NCI Drug Dictionary: AZD9833</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fulvestrant' target='_blank'>NCI Drug Dictionary: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Fulvestrant' target='_blank'>Wikipedia: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Selective_estrogen_receptor_degrader' target='_blank'>Wikipedia: Selective Estrogen Receptor Degrader (SERD)</a> </li></ul>
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391

NEAREST SITE: 2013 miles
University of Alabama at Birmingham
Birmingham,AL

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03368729

Niraparib and Herceptin in Women With Metastatic HER2+ Breast Cancer

A Phase 1b/2 Study of the PARP Inhibitor Niraparib in Combination With Trastuzumab in Patients With Metastatic HER2+ Breast Cancer Scientific Title

Purpose
To look at the safety, effects (good and bad), and anti-cancer activity of combining niraparib (Zejula®) with trastuzumab (Herceptin®).
Who is this for?
Women with metastatic (stage IV) HER2 positive (HER2+) breast cancer who have already been treated with a HER2 targeted therapy, have not been treated with a PARP inhibitor, and do not have a hereditary BRCA1/2 mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Niraparib (Zejula®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Zejula is at type of targeted therapy called a PARP inhibitor. It works by blocking poly (ADP-ribose) polymerase, an enzyme that helps cancer cells grow by repairing their DNA. It is approved to treat women with certain types of reproductive cancers. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Herceptin is a HER2-targeted therapy approved to treat HER2 positive breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03368729' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.zejula.com/en' target='_blank'>Drug Company Information Page: Zejula® (Niraparib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/herceptin?gclid=Cj0KCQiAyKrxBRDHARIsAKCzn8zEHqEyTfwjNEW138WZ4GeUdB3CVmQfk-GJ5zPldOhQ2p6lEMBu1fsaAt6rEALw_wcB' target='_blank'>Breastcancer.org: Herceptin</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/parp-inhibitors-in-breast-cancer-treatment' target='_blank'>Breast Cancer Now: PARP Inhibitors in Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedaily.com/releases/2012/09/120917084946.htm' target='_blank'>ScienceDaily: PARP Inhibitors May Have Clinical Utility in HER2-positive Breast Cancers</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/25128455' target='_blank'>PubMed Abstract: Poly (ADP-ribose) Polymerase Inhibition Enhances Trastuzumab Antitumour Activity in HER2 Overexpressing Breast Cancer.</a> </li></ul>
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392

NEAREST SITE: 2064 miles
University of Toledo
Toledo,OH

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT04232319

Online Program with an Occupational Therapist for Women Who Have Been Treated for DCIS, Stage I, Stage II, or Stage III Breast Cancer and Have Sleep Problems

Feasibility of a Sleep Hygiene Education Program for Sleep Issues in Breast Cancer Survivors Scientific Title

Purpose
To evaluate whether an online program with an occupational therapist who teaches sleep hygiene can improve quality of sleep.
Who is this for?
Women who were treated for DCIS, stage I, stage II, or stage III breast cancer who are not receiving chemotherapy or radiation, are having sleep problems, and are not taking a pharmacological sleep aide.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Online session with an occupational therapist, weekly, for 30 to 45 minutes, for 3 weeks</li> <li class="seamTextUnorderedListItem">A workbook about sleep hygiene (habits) and strategies to improve quality of sleep</li> <li class="seamTextUnorderedListItem">Help from the occupational therapist about how to apply different sleep habits and strategies from the workbook</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study will evaluate whether an online program with an occupational therapist who teaches sleep hygiene can improve quality of sleep.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04232319' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sleepfoundation.org/articles/sleep-hygiene' target='_blank'>SleepFoundation.org: What is Sleep Hygiene?</a> </li></ul>
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393

NEAREST SITE: 2088 miles
Barbara Ann Karmanos Cancer Institute
Detroit,MI

VISITS: 1 visit

PHASE: NA

NCT ID: NCT01698658

Evaluating the SoftVue Technique for Breast Imaging

Clinical Data Collection for Initial Evaluation of SoftVue: a Novel Ultrasound Breast Scanner Scientific Title

Purpose
To see how the images SoftVue provides compare to those provided by these other methods.
Who is this for?
Women scheduled for mammogram, breast ultrasound and/or breast MRI    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Patients undergo ultrasound tomography using SoftVue. Some patients also undergo MRI of the breast.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SoftVue is a new technique that may improve breast cancer detection. </li> <li class="seamTextUnorderedListItem">It involves submerging the breast in warm water inside an ultrasound transducer ring, which creates detailed, three-dimensional images of the breast.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01698658' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.prnewswire.com/news-releases/ultrasound-breast-cancer-imaging-device-created-at-the-karmanos-cancer-institute-one-step-closer-to-fda-approval-188641301.html' target='_blank'>PRNewsWire: SoftVue</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.karmanos.org/Video/View.aspx?&sid=1&VideoID=55' target='_blank'>Video: News story</a> </li></ul>
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394

NEAREST SITE: 2088 miles
Karmanos Cancer Institute
Detroit,MI

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT02632448

LY2880070 in Advanced Triple Negative Breast Cancer

A Phase 1b/2a Two-Part Open-Label Multicenter Study to Evaluate the Safety and Efficacy of LY2880070 as Monotherapy and in Combination With Gemcitabine in Patients With Advanced or Metastatic Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of an investigational drug called LY2880070.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR- and HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY2880070, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY2880070, by mouth</li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY2880070 inhibits CHK1, which may improve how a tumor responds to a chemotherapy drug. </li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®) is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">This study will also enroll patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02632448' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/druglist/gemzar' target='_blank'>Breastcancer.org: Gemzar</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/gemcitabine-gemzar#who' target='_blank'>BreastCancerNow.org: Gemzar</a> </li></ul>
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395

NEAREST SITE: 2108 miles
Ohio State University Comprehensive Cancer Center
Columbus,OH

VISITS: Weekly visits

PHASE: II

NCT ID: NCT02760030

Faslodex & Ibrance for People Age 70 & Older with Stage I-III Breast Cancer

Phase II Trial of Primary Endocrine Therapy With Combination of Fulvestrant and Palbociclib in Elderly Patients With Hormone Responsive Breast Cancer Who Have Inoperable Tumor Or Operable Tumor But Cannot Undergo Surgery Due to Frailty Or Who Refuse Surgery Scientific Title

Purpose
To study the effects (good and bad) of giving fulvestrant and palbociclib to older patients who will not have surgery.
Who is this for?
People, 70 or older, who were recently diagnosed with stage I, stage II or stage III breast cancer and elected to not have surgery. Your tumor must be hormone receptor positive (ER+ and/or PR+) and HER2 negative.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, weekly, 2 weeks on, 2 week off</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, 3 weeks on, 1 week off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some older people diagnosed with early-stage breast cancer do not have surgery.</li> <li class="seamTextUnorderedListItem">Two drugs now used to treat breast cancer that has spread to other parts of the body may be a good treatment option for these patients.</li> <li class="seamTextUnorderedListItem">The drugs are called fulvestrant (Faslodex®) and palbociclib (Ibrance®).</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is an anti-estrogen therapy used to treat metastatic hormone positive tumors in postmenopausal women.</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a targeted therapy. It keeps cancer cells from growing by blocking two enzymes, CDK4 and CDK6.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02760030' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://malebreastcancercoalition.org' target='_blank'>Male Breast Cancer Coalition</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/erds/faslodex' target='_blank'>Breastcancer.org: Faslodex</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Palbociclib' target='_blank'>Wikipedia: Palbociclib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com' target='_blank'>Pfizer Oncology Information Page: Ibrance</a> </li></ul>
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396

NEAREST SITE: 2108 miles
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
Columbus,OH

VISITS: Visits weekly

PHASE: II

NCT ID: NCT02203552

Antibiotic to Prevent Memory Problems, Anxiety & Depression in Patients on Adriamycin

Randomized Placebo Controlled Study of Minocycline for Amelioration of Chemotherapy Induced Affective Disorders Scientific Title

Purpose
To see if giving the drug Minocycline (Minocin) to women who are receiving Adriamycin will keep side effects such as problems with memory and thinking skills, anxiety, and/or depression, from developing.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who are schedule to receive adriamycin chemotherapy before or after breast cancer surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Minocycline (Minocin), by mouth, twice daily for 9 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, twice daily for 9 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Women who receive the chemotherapy drug doxorubicin (Adriamycin®) as part of their breast cancer treatment may develop problems with their memory and thinking skills, anxiety, and/or depression. </li> <li class="seamTextUnorderedListItem">Researchers think giving the drug Minocycline (Minocin) to women who are receiving Adriamycin may keep these side effects from developing. </li> <li class="seamTextUnorderedListItem">Minocin is is an antibiotic you take by mouth to treat infections.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02203552' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/show/NCT02203552' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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397

NEAREST SITE: 2108 miles
Ohio State University Medical Center
Columbus,OH

VISITS: 3-4 visits, over 6 months

PHASE: I

NCT ID: NCT01376505

Vaccine Therapy for HER2+ Metastatic Breast Cancer

Phase I Active Immunotherapy Trial With a Combination of Two Chimeric (Trastuzumab-like and Pertuzumab-like) HER-2 B Cell Peptide Vaccine Emulsified in ISA 720 and Nor-MDP Adjuvant in Patients With Advanced Solid Tumors Scientific Title

Purpose
To determine the best dose for and the side effects of a new HER2 vaccine when it is used to treat individuals with HER2+ metastatic breast cancer.
Who is this for?
People with stage IV breast cancer for whom currently available therapy does not exist.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following treatment, based on a 21-day cycle: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HER2 vaccine by injection for 3 cycles</li> </ul> <p class="seamTextPara"> Participants may receive booster vaccination at 6 months.</p>
  • <p class="seamTextPara"> Researchers are studying whether vaccines can teach the body's immune system to kill cancer cells. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">About 30% of all breast tumors make too much of a protein called human epidermal growth factor receptor 2 (HER2). Scientists believe a vaccine that incorporates a small amount of the HER2 protein may get the immune system to recognize and go after HER2+ cancer cells.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01376505' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancer.osu.edu/mediaroom/releases/Pages/A-New-Anticancer-Vaccine-Study-Starts-At-The-James.aspx' target='_blank'>Ohio State University: Study Summary</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/tips/immune/helping.jsp' target='_blank'>BreastCancer.org: Cancer Vaccines</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/factsheet/Therapy/cancer-vaccines' target='_blank'>NCI Fact Sheet: Cancer Vaccines</a> </li></ul>
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398

NEAREST SITE: 2108 miles
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Wexner Medical Center
Columbus,OH

VISITS: At least 2 visits

PHASE: NA

NCT ID: NCT02415387

Typhoid Vaccine to Study Immune Response in Patients Who Received Chemotherapy

The IMPACT Study: Inflammatory Responses, Mood and Physical Fitness After Cancer Treatment Scientific Title

Purpose
To investigate how women who have completed treatment for early-stage breast cancer respond to a typhoid vaccine by measuring their cardiorespiratory fitness, natural inflammatory reaction, and behavioral responses such as depression, fatigue, pain, and problems with thinking and reasoning.
Who is this for?
Women who are postmenopausal and have received chemotherapy as part of breast cancer treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Typhoid vaccine, by injection, on first visit</li> <li class="seamTextUnorderedListItem">followed by placebo, by injection, on second visit (2 weeks to 1 month later)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by injection, on first visit</li> <li class="seamTextUnorderedListItem">followed by typhoid vaccine, by injection, on second visit (2 weeks to 1 month later)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy can weaken the body's immune system. </li> <li class="seamTextUnorderedListItem">Physical fitness may protect the body from the effects that chemotherapy has on the immune system as well as reduce other health problems. </li> <li class="seamTextUnorderedListItem">Giving patients a typhoid vaccine allows researchers to study their immune response.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02415387' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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399

NEAREST SITE: 2108 miles
Ohio State University
Columbus,OH

VISITS: Visits every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03414684

Carboplatin plus Nivolumab in Advanced Triple Negative Breast Cancer

A Randomized Phase II Trial of Carboplatin With or Without Nivolumab in First- or Second-line Metastatic Triple-negative Breast Cancer Scientific Title

Purpose
To compare the safety and effect (good and bad) of giving the chemotherapy drug carboplatin (Paraplatin®) alone or with an immunotherapy drug to treat advanced breast cancer.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-/PR-/HER2-) breast cancer. You may have received up to one prior regimen of chemotherapy for metastatic cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, every 3 weeks, ongoing</li></ul>
  • <p class="seamTextPara"> Paraplatin is a chemotherapy drug routinely used to treat advanced breast cancer. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy drug used in this study is the PD-1 inhibitor nivolumab (Opdivo®). The drug, which has been approved to treat certain types of cancer, but not breast cancer, stimulates the body's immune system to attack cancer cells by blocking a protein called PD-1 (programmed cell death-1).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03414684' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://triplesteptowardthecure.org/' target='_blank'>Triple Step Toward the Cure</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/cancerwise/2015/04/finding-hope-after-triple-negative-breast-cancer.html' target='_blank'>MDAnderson: Finding Hope After Triple Negative Breast Cancer</a> </li></ul>
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400

NEAREST SITE: 2108 miles
Ohio State University Comprehensive Cancer Center
Columbus,OH

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03535701

Ketogenic Diet and Taxol for Metastatic Breast Cancer

Ketogenic Diet and Chemotherapy to Affect Recurrence of Breast Cancer (The KETO-CARE Study) Scientific Title

Purpose
To study whether a ketogenic diet helps the chemotherapy drug paclitaxel (Taxol®) control tumor growth.
Who is this for?
People with metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), standard of care</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ketogenic diet (with meals prepared in the research kitchen), for 3 months</li> <li class="seamTextUnorderedListItem">Free living ketogenic diet program (group and individual sessions, online educational content) for 3 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), standard of care</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A ketogenic diet is a low-carbohydrate diet. </li> <li class="seamTextUnorderedListItem">Eating fewer carbohydrates forces the body to burn stored fat. </li> <li class="seamTextUnorderedListItem">Laboratory studies suggest being on a ketogenic diet may reduce inflammation and help chemotherapy drugs control tumor growth. </li> <li class="seamTextUnorderedListItem">Taxol is a chemotherapy drug routinely used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03535701' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fredhutch.org/en/news/center-news/2019/10/keto-fat-cancer-its-complicated.html' target='_blank'>Fred Hutchinson Cancer Research Center: Keto, Fat, and Cancer--It's Complicated</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/cancerwise/the-keto-diet-and-cancer--what-patients-should-know.h00-159223356.html' target='_blank'>MD Anderson Cancer Center: The Keto Diet and Cancer: What Patients Should Know</a> </li></ul>
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401

NEAREST SITE: 2108 miles
Mount Carmel West Hospital
Columbus,OH

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT03536897

Radiation During Breast Cancer Surgery in Women Age 65 and Older

Intraoperative Radiation Therapy (IORT) Following Breast Conserving Surgery for Early Stage Breast Cancer Registry Scientific Title

Purpose
To develop a registry that will allow researchers to study the 5-year risk of a local breast cancer recurrence after intraoperative radiation therapy (IORT).
Who is this for?
Women age 65 or older with stage II or stage III low- risk breast cancer who will be treated with partial mastectomy (lumpectomy) and radiation during surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">IORT (Intraoperative radiation), during surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiation therapy (IORT) is given right after the tumor has been removed while you are still in the operating room.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03536897' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/tests-procedures/intraoperative-radiation-therapy/about/pac-20385150' target='_blank'>Mayo Clinic: Intraoperative radiation therapy (IORT)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tricitymed.org/2016/10/iort-breast-cancer-treatment-primer/' target='_blank'>Tricity Medicine: IORT as Breast Cancer Treatment: A Primer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.uptodate.com/contents/overview-of-the-approach-to-early-breast-cancer-in-older-women' target='_blank'>UpToDate: Overview of the approach to early breast cancer in older women</a> </li></ul>
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402

NEAREST SITE: 2108 miles
Ohio State University Comprehensive Cancer Center
Columbus,OH

VISITS: Number of visits unavailable, over 5 weeks

PHASE: II

NCT ID: NCT03786354

3D Radiation Therapy To Reduce Side Effects For Lymph-Node Positive Breast Cancer

Prospective Evaluation of Shoulder Morbidity in Patients With Lymph-Node Positive Breast Cancer Receiving Regional Nodal Irradiation Scientific Title

Purpose
To compare the shoulder- and upper arm-related side effects of intensity-modulated radiation therapy to those of 3-dimensional conformal radiation therapy.
Who is this for?
Women with stage II or stage III breast cancer who have had a lumpectomy or a mastectomy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intensity-Modulated Radiation Therapy (IMRT), over 5 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3-Dimensional Conformal Radiation Therapy (3DCRT), over 5 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy can affect the muscles in the shoulder and upper arm. </li> <li class="seamTextUnorderedListItem">Intensity-modulated radiotherapy (IMRT) is a widely used type of radiation therapy. </li> <li class="seamTextUnorderedListItem">3-dimensional conformal radiation therapy (3DCRT) is a newer type of radiation therapy that may result in fewer side effects.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03786354' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/issues/july-10-2016/managing-upper-extremity-dysfunction-in-breast-cancer-survivors/' target='_blank'>ASCO Post: Managing Upper Extremity Dysfunction in Breast Cancer Survivors</a> </li><li class='seamTextUnorderedListItem'><a href='https://conquer-magazine.com/categories/breast-cancer/394-shoulder-pain-and-breast-cancer' target='_blank'>Conquer: Shoulder Pain and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healthline.com/health/breast-cancer/why-do-i-have-arm-shoulder-pain' target='_blank'>Heathline: Breast Cancer: Why Do I Have Arm and Shoulder Pain?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.radiologyinfo.org/en/info.cfm?pg=imrt' target='_blank'>UCSF Radiology: Intensity-Modulated Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://radonc.ucsf.edu/three-dimensional-conformal-radiation-therapy-3dcrt' target='_blank'>UCSF Radiology: 3-Dimensional Conformal Radiation Therapy</a> </li></ul>
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403

NEAREST SITE: 2133 miles
John B. Amos Cancer Center
Columbus,GA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03691493

Radiation Therapy, Palbociclib & Hormone Therapy for Breast Cancer Related Bone Metastases

A Phase II Multi-Institutional Study of Concurrent Radiotherapy, Palbociclib, and Hormone Therapy for Treatment of Bone Metastasis in Breast Cancer Patients Scientific Title

Purpose
To study the effects (good and bad) of using radiation therapy along with the targeted therapy palbociclib (Ibrance®) and hormone therapy.
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer that has spread to the bone.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy, daily, for 5-10 days</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, for 3 out of every 4 weeks</li> <li class="seamTextUnorderedListItem">Your doctor's choice of hormone therapy: letrozole, anastrozole, exemestane, tamoxifen, or fulvestrant</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a type of targeted therapy called a CDK 4/6 inhibitor. It is used along with a hormone therapy to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">The hormone therapies used along with Ibrance are fulvestrant (Faslodex®), letrozole (Femara®), anastrozole (Arimidex®), exemestane (Aromasin®) and tamoxifen.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03691493' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/79/4_Supplement/PD8-12' target='_blank'>AACR Cancer Research Abstract: Safety and efficacy of palbociclib and radiotherapy in MBC</a> </li></ul>
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404

NEAREST SITE: 2133 miles
Piedmont Cancer Institute, PC
Atlanta,GA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT04060862

Ipatasertib or Placebo Plus Palbociclib + Fulvestrant in Advanced HR+, HER2- Breast Cancer

A Phase Ib/III Study of Ipatasertib Plus Palbociclib and Fulvestrant Versus Placebo Plus Palbociclib and Fulvestrant in Hormone Receptor Positive and HER2 Negative Locally Advanced Unresectable or Metastatic Breast Cancer Scientific Title

Purpose
To look at whether adding the experimental drug ipatasertib to the currently used treatment regimen of fulvestrant (Faslodex®) and palbociclib (Ibrance®) is more effective than Faslodex, Ibrance, and a placebo.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) hormone positive, HER2 negative (HR+, HER2-) breast cancer that recurred (came back) or progressed while you were on an anti-estrogen therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> <i class="seamTextEmphasis">You will be randomly assigned to 1 of 2 groups:</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib, by mouth, daily, 3 weeks on, 1 week off, ongoing</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) , by mouth, daily, 3 weeks on, 1 week off, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) , by injection, 1 or 2 times a month, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily, 3 weeks on, 1 week off, ongoing</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, 3 weeks on, 1 week off, ongoing</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 1 or 2 times a month, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib is a targeted therapy that blocks AKT, a protein that helps cancer cells grow.</li> <li class="seamTextUnorderedListItem">Faslodex is an anti-estrogen therapy approved to treat advanced breast cancer in postmenopausal women. </li> <li class="seamTextUnorderedListItem">Ibrance is a type of targeted therapy called a CDK 4/6 inhibitor. It is approved to treat metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04060862' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ipatasertib' target='_blank'>NCI Drug Dictionary: Ipatasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ibrance.com/about-ibrance?src_code=IBRW10028851' target='_blank'>Pfizer Oncology: Ibrance®</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/erds/faslodex' target='_blank'>Breastcancer.org: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/issues/may-10-2019/postprogression-treatment-of-estrogen-receptor-positive-breast-cancer/' target='_blank'>ASCO: Postprogression Treatment of ER+ Breast Cancer</a> </li></ul>
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405

NEAREST SITE: 2139 miles
Research Facility
Atlanta,GA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT02643303

A Combination of Three Immunotherapies for Advanced Breast Cancer

A Phase 1/2 Study of In Situ Vaccination With Tremelimumab and IV Durvalumab (MEDI4736) Plus the Toll-like Receptor Agonist PolyICLC in Subjects With Advanced, Measurable, Biopsy-accessible Cancers Scientific Title

Purpose
To study the safety and anti-cancer activity of giving a combination of three different types of immunotherapies, including a PD-L1 inhibitor.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by IV</li> <li class="seamTextUnorderedListItem">Tremelimumab, by IV</li> <li class="seamTextUnorderedListItem">Poly ICLC (Hiltonol®), by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®) is a type of immunotherapy called a PD-L1 (programmed cell death ligand-1) inhibitor. It has been approved to treat certain types of cancers but its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">Tremelimumab is a type of immunotherapy called a CTLA4 inhibitor.</li> <li class="seamTextUnorderedListItem">Poly ICLC (Hiltonol®) is an immune cell activating factor.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02643303' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncovir.com' target='_blank'>Oncovir Drug Information Page: Hiltonol® (Poly ICLC)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/poly-iclc' target='_blank'>NCI Drug Dictionary: Poly ICLC</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.imfinzihcp.com/durvalumab-clinical-trials.html?source=imz_n_h_9&umedium=cpc&uadpub=google&ucampaign=2019imfinzihcpnsclcbranded_general_hcp&ucreative=branded_alone_ex&uplace=durvalumab&outcome=hcp&cmpid=1' target='_blank'>AstraZeneca Drug Information Page: Imfinzi® (Durvalumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Tremelimumab' target='_blank'>Wikipedia: Tremelimumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tremelimumab' target='_blank'>NCI Drug Dictionary: Tremelimumab</a> </li></ul>
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406

NEAREST SITE: 2139 miles
Emory University Hospital
Atlanta,GA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02803593

Computer and Internet-Based Support Program for Asian-American Breast Cancer Survivors

To Enhance Breast Cancer Survivorship of Asian Americans Scientific Title

Purpose
To evaluate whether an internet and computer-based information and coaching/support program designed specifically for Asian-American breast cancer survivors improves quality of life
Who is this for?
Women who have been diagnosed with breast cancer within the past 5 years and identify as Chinese, Korean, or Japanese. You must also have access to the internet through a computer, smartphone or tablet.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Support Care Needs survey at baseline</li> <li class="seamTextUnorderedListItem">Receive culturally tailored internet and computer-based information and coaching/support in one of four languages (English, Mandarin Chinese, Korean, and Japanese)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Support Care Needs survey at baseline</li> <li class="seamTextUnorderedListItem">Standard support provided by American Cancer Society</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The program is provided in English, Mandarin Chinese, Korean, and Japanese.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02803593' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.dukecancerinstitute.org/news/cancer-survivorship-asian-americans' target='_blank'>Duke Cancer Institute: Cancer Survivorship of Asian Americans</a> </li></ul>
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407

NEAREST SITE: 2139 miles
Emory University/Winship Cancer Institute
Atlanta,GA

VISITS: Monthly visits for 6 months

PHASE: I

NCT ID: NCT02897375

Ibrance with Cisplatin or Carboplatin for Advanced Breast (and Other) Cancer

A Phase 1 Study of Palbociclib in Combination With Cisplatin or Carboplatin in Advanced Solid Malignancies Scientific Title

Purpose
To look at the safety and effects (good and bad) of two different drug combinations.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups and receive the following for up to 6 months: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Cisplatin (Platinol®), by IV, once, monthly</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Carboplatin (Paraplatin®), by IV, once, monthly</li></ul>
  • <p class="seamTextPara"> To take part in this study, you must have been diagnosed with stage III or stage IV (metastatic) breast cancer. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">All patients in this study will receive palbociclib (Ibrance®) with a chemotherapy drug, either cisplatin (Platinol®) or carboplatin (Paraplatin®).</li> <li class="seamTextUnorderedListItem">Ibrance is a new type of targeted drug called a CDK inhibitor. It is approved to treat postmenopausal women with ER-positive, HER2-negative metastatic breast cancer who have not already had an anti-estrogen drug. </li> <li class="seamTextUnorderedListItem">The two chemotherapy drugs, Platinol and Paraplatin, are are used to treat advanced breast cancer that has not responded to previous chemotherapy treatments. </li> <li class="seamTextUnorderedListItem">This is a Phase I trial.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02897375' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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408

NEAREST SITE: 2139 miles
Emory University
Atlanta,GA

VISITS: Daily visits for 3 weeks

PHASE: NA

NCT ID: NCT03167359

Three Weeks of Radiation for Women Under 50 with DCIS or Stage I-III Breast Cancer

A Pilot Study of Hypofractionated Simultaneous Integrated Boost Radiotherapy in Stage 0, I and III Breast Cancer Patients Scientific Title

Purpose
To see if giving 3 weeks of daily radiation therapy after surgery, instead of the standard 6, improves quality of life and reduces side effects such as lymphedema and fatigue.
Who is this for?
Women with DCIS or stage I, stage II, or stage III breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Daily radiation treatment for 3 weeks (15 sessions)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Because the number of breast cancer survivors has increased, researchers want to reduce the toxicities and inconveniences of the traditional 6 weeks of daily radiation treatment.</li> <li class="seamTextUnorderedListItem">The researchers will see if the shorter time period improves women's quality of life and reduces side effects such as lymphedema and fatigue.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03167359' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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409

NEAREST SITE: 2163 miles
Metro Health Medical Center
Cleveland,OH

VISITS: 1-3 visit per week for 5 months

PHASE: NA

NCT ID: NCT02763228

An Exercise Study for Older African-American and White Breast Cancer Survivors

A Physical Activity Intervention to Reduce Functional Health Disparities Among Older Breast Cancer Survivors Scientific Title

Purpose
To study whether older breast cancer survivors who take part in an exercise program offered in their community have improved quality of life.
Who is this for?
Women 65 or older who have been treated for stage I, stage II, or stage III breast cancer within the last 5 years. You must also identify as non-Hispanic white or African-American.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Exercise Group</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking program on your own, 1-3 times per week, for 1 year</li> <li class="seamTextUnorderedListItem">Aerobic and resistance training with a trainer, 3 times per week, for 5 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aerobic and resistance training with a trainer, on your own schedule, for 8 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Support Group</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health Education and Support Group sessions, weekly, for 5 months</li> <li class="seamTextUnorderedListItem">Encouraged to participate in any Support Group sessions offered regularly, on your own schedule, for 8 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You may be assigned to a group that will exercise by walking and by using resistance training, some of which will be with a personal trainer. </li> <li class="seamTextUnorderedListItem">You may be assigned to a group that will attend a Health Education and Support Group. </li> <li class="seamTextUnorderedListItem">The researchers also want to see if there are differences in how African-American and white breast cancer survivors respond to the exercise program.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02763228' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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410

NEAREST SITE: 2223 miles
Greenville Health System Center Institute
Greenville,SC

VISITS: 1 visit every week or every other week

PHASE: I

NCT ID: NCT03847168

KN026 for Advanced HER2 Positive Breast Cancer

Phase I Study of KN026 in HER2 Expressing Breast Cancer, Astric/Gastroesophageal Junction Cancer and Other Locally Advanced/Metastatic Solid Tumors Scientific Title

Purpose
To determine the safety, best dose and effects (good and bad) of KN026, an experimental HER2 targeted therapy.
Who is this for?
People with HER2 positive advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">KN026, by IV, every week or every other week</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">KN026 is an experimental HER2 targeted therapy. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with stomach cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03847168' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.biospace.com/article/releases/alphamab-oncology-s-her2-bispecific-antibody-kn026-gained-us-ind-approval-phase-i-clinical-trial-started-in-china/' target='_blank'>Biospace: Alphamab Oncology's HER2 bispecific antibody KN026</a> </li></ul>
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411

NEAREST SITE: 2246 miles
Virginia K Crosson Cancer Center
Fullerton,CA

VISITS: 1 to 4 appointments (by phone or in person) a month, for 1 year

PHASE: NA

NCT ID: NCT03154190

Supportive Care for People With Metastatic Breast Cancer

St. Judes-Stanford Comprehensive Support Initiative Scientific Title

Purpose
To learn whether supportive care from a health care coach is better than standard support for helping you make treatment decisions that include concerns about symptom management.
Who is this for?
People with newly diagnosed metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Health Care Coach Support</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sessions with a health care coach, by phone or in person, 1 at baseline and 1 after first oncology appointment</li> <li class="seamTextUnorderedListItem">Sessions with a health care coach, by phone or in person, weekly or monthly (based on need), for 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care Support</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care support</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health care coaches are trained to talk to and educate cancer patients and their family members about care goals and shared decision making.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03154190' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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412

NEAREST SITE: 2258 miles
University of Pittsburgh
Pittsburgh,PA

VISITS: Visits 3 times a week over 6 months

PHASE: NA

NCT ID: NCT02793921

An Exercise Program to Improve Thinking and Memory in Women on an Aromatase Inhibitor

Influence of Exercise on Neurocognitive Function in Breast Cancer Scientific Title

Purpose
To see if taking part in a supervised aerobic exercise program during the first 6 months on an aromatase inhibitor will help improve thinking, memory, learning, attention and other brain functions.
Who is this for?
Women who have had surgery for stage I, stage II, or stage III breast cancer and are planning to start on a type of anti-estrogen drug called an aromatase inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A supervised aerobic exercise program, 3 times a week, during the first 6-months of aromatase inhibitor therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Normal physical activity (neither limited or withheld), during the first 6-months of aromatase inhibitor therapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Problems with thinking, memory and other brain functions are a common side effect of the aromatase inhibitors. </li> <li class="seamTextUnorderedListItem">The aromatase inhibitors are anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®). </li> <li class="seamTextUnorderedListItem">All three are used to treat hormone receptor positive (ER+ and/or PR+) tumors in postmenopausal women.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02793921' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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413

NEAREST SITE: 2260 miles
Allegheny Health Network (AHN) - Allegheny General Hospital ONLY
Pittsburgh,PA

VISITS: 1 visit a week for 3 weeks, then monthly visits thereafter

PHASE: II

NCT ID: NCT02738866

Palbociclib With Fulvestrant for ER+, HER2- Advanced Breast Cancer

Phase II Trial of Palbociclib With Fulvestrant in Individuals With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer Who Have Progressed on Treatment With Palbociclib and an Aromatase Inhibitor Scientific Title

Purpose
To study the safety and effects (good and bad) of using Ibrance and Faslodex to treat people with advanced breast cancer who have previously been treated with Ibrance and an aromatase inhibitor.
Who is this for?
People with ER positive, HER2 negative advanced (some stage III) or metastatic (stage IV) breast cancer and have already been treated with palbociclib (Ibrance®) and an aromatase inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, once daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, once a week for 3 weeks then once a month thereafter</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a CDK4/6 inhibitor approved to treat hormone receptor positive (ER+ and/or PR+), HER2 negative breast cancer in combination with an anti-estrogen therapy. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is an anti-estrogen therapy approved to treat postmenopausal women with metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02738866' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://pubchem.ncbi.nlm.nih.gov/compound/Fulvestrant#section=Top' target='_blank'>PubChem: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.astrazeneca.com/media-centre/press-releases/2017/faslodex-receives-us-fda-approval-as-monotherapy-for-expanded-use-in-breast-cancer.html' target='_blank'>AstraZeneca Press Release: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/targeted-therapy/palbociclib-ibrance#what%20is%20palbociclib' target='_blank'>BreastCancerCare UK: Palbociclib</a> </li></ul>
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414

NEAREST SITE: 2264 miles
Magee-Womens Hospital UPMC
Pittsburgh,PA

VISITS: Monthly visits, ongoing

PHASE: II

NCT ID: NCT02913430

Faslodex or Tamoxifen for ER-Positive Metastatic Breast Cancer

Treatment of Metastatic Breast Cancer With Fulvestrant or Tamoxifen: A Randomized Phase II Trial With ESR1 Mutation Tested in Circulating Tumor DNA Scientific Title

Purpose
To compare how well two different anti-estrogen drugs keep metastatic breast cancer from spreading.
Who is this for?
People with estrogen receptor positive metastatic (stage IV) breast cancer. You must not have received Faslodex or Tamoxifen since being diagnosed with metastatic breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, every 4 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two drugs are fulvestrant (Faslodex®) and tamoxifen (Nolvadex®). Both are used to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">The researchers will use blood tests to study each patient's circulating tumor DNA, DNA from the cancer that floats in the blood stream, in order to learn more about a mutation called ESR1 and why hormone-sensitive tumors stop responding to anti-estrogen treatments.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02913430' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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415

NEAREST SITE: 2265 miles
UPMC
Pittsburgh,PA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04144140

Immunotherapy Injected Directly Into Advanced Breast Cancer Tumors

An Open-Label, Multicenter Phase 1/1b Study of Intratumorally Administered STING Agonist E7766 in Subjects With Advanced Solid Tumors or Lymphomas - INSTAL-101 Scientific Title

Purpose
To study the safety, best dose, and effects (good and bad) of an immunotherapy that is injected directly into tumors. You must have at least one tumor that is 1 to 3 cm in size.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">E7766, by injection, directly into your tumor(s)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">At least 1 biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">E7766 is an experimental immunotherapy that is only available in clinical trials. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04144140' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/799924' target='_blank'>NCI Drug Dictionary: E7766</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li></ul>
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416

NEAREST SITE: 2293 miles
Carolina BioOncology Institute
Huntersville,NC

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04244552

ATRC-101 (An Experimental Immunotherapy) for Advanced Breast Cancer

A First-in-Human Phase 1b Dose Escalation Trial to Investigate the Safety, Tolerability, Pharmacokinetics, and Biological Activity of ATRC-101 in Adults With Advanced Solid Malignancies Scientific Title

Purpose
To study the safety and effects (good and bad) of the experimental immunotherapy ATRC-101.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ATRC-101</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ATRC-101 is a new drug that is designed to get the immune system to see and attack cancer cells. </li> <li class="seamTextUnorderedListItem">It is also believed to change the microenvironment (the area that surrounds the cancer cells), which may make it easier for the immune cells to kill the cancer cells.</li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of solid cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04244552' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.atreca.com/pipeline/' target='_blank'>Drug Company Information Page: ATRC-101</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/immunotherapy.html' target='_blank'>American Cancer Society: Immunotherapy for Breast Cancer</a> </li></ul>
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417

NEAREST SITE: 2299 miles
Levine Cancer Institute
Charlotte,NC

VISITS: 1 visit before surgery

PHASE: NA

NCT ID: NCT02522468

Comparing Two Ways to Mark Tumor Location Before Breast Cancer Surgery

A Randomized Single-Center Superiority Trial of Radioactive Seed Localization Versus Needle Localization for Malignant Breast Disease. Scientific Title

Purpose
To compare two ways to mark a tumor's location before surgery: radioactive seed localization (RSL) and wire-guided localization (WL).
Who is this for?
Women with stage 0 (DCIS), stage I, stage II or stage IIIA breast cancer who are going to have breast conservation surgery (often referred to as a lumpectomy) and have not had any other breast cancer treatments.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radioactive Seed Localization (a tiny metal seed placed into the breast tissue to show a surgeon which piece to remove), during a mammogram or ultrasound, prior to surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Wire-guided localization (a wire inserted into the breast tissue to show a surgeon which piece to remove), during a mammogram or ultrasound, prior to surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by surgery</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radioactive seed localization (RSL) involves placing tiny metal seeds in the breast to mark the tumor's location. </li> <li class="seamTextUnorderedListItem">Wire-guided localization (WL) involves placing a small wire into the breast tissue to mark the tumor's location.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02522468' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/breast-seed-localization' target='_blank'>Memorial Sloan Kettering Cancer Center: Radioactive Seed Localization</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/breast-cancer/getting-diagnosed/tests-diagnose/wire-guided-excision-biopsy' target='_blank'>Cancer Research UK: Wire guided excision biopsy</a> </li></ul>
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418

NEAREST SITE: 2299 miles
Levine Cancer Institute
Charlotte,NC

VISITS: Weekly visits

PHASE: II

NCT ID: NCT03018080

Keytruda plus Taxol for Metastatic HER2 Negative Breast Cancer

LCI-BRE-H2N-PEPP-001: A Pilot Study of Paclitaxel Plus Pembrolizumab in Patients With Metastatic HER2-Negative Breast Cancer (The PePPy Trial) Scientific Title

Purpose
To compare two different treatment plans using Keytruda and Taxol.
Who is this for?
People with metastatic (stage IV) HER2 negative (HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (2 weeks on, 1 weeks off) for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (2 weeks on, 1 week off), ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (2 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Two different treatment plans are studied in this trial. </li> <li class="seamTextUnorderedListItem">In one plan, patients will receive Taxol followed by Taxol and Keytruda at the same time. In the other, patients will receive Taxol and Keytruda at the same time. </li> <li class="seamTextUnorderedListItem">Taxol is routinely used to treat breast cancer.</li> <li class="seamTextUnorderedListItem">Keytruda is approved to treat certain types of cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03018080' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda</a> </li></ul>
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419

NEAREST SITE: 2299 miles
Roswell Park Cancer Institute
Buffalo,NY

VISITS: 4 visits over the first 2 weeks, then 1 visit every 3 weeks for 2 years

PHASE: NA

NCT ID: NCT03599453

Chemokine Modulation and Keytruda in Advanced Triple Negative Breast Cancer

Pilot Open Label Clinical Trial Evaluating the Safety and Efficacy of Chemokine Modulation to Enhance the Effectiveness of Pembrolizumab in Patients With Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of using chemokine modulation therapy before treatment with pembrolizumab (Keytruda®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-) that has not responded to other treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Celecoxib (Celebrex®), by mouth, twice daily</li> <li class="seamTextUnorderedListItem">Interferon Alfa-2b, by IV, 3 times over 2 weeks </li> <li class="seamTextUnorderedListItem">Rintatolimod, by IV, 3 times over 2 weeks</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, for 2 years</li> <li class="seamTextUnorderedListItem">2 biopsies (before treatment and during treatment)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy drug called a PD-1 (programmed cell death-1) inhibitor. It is approved to treat at least 10 different types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Small proteins called chemokines help get the immune cells to specific organs. </li> <li class="seamTextUnorderedListItem">Celecoxib (Celebrex®), recombinant interferon alfa-2b, and rintatolimod (Ampligen) each works in a different way to get chemokines to an organ. </li> <li class="seamTextUnorderedListItem">Chemokine modulation therapy may make Keytruda more effective.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03599453' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/rintatolimod' target='_blank'>NCI Drug Dictionary: Rintatolimod</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/recombinant-interferon-alfa-2b' target='_blank'>NCI Drug Dictionary: Interferon Alfa-2b</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/celecoxib' target='_blank'>NCI Drug Dictionary: Celecoxib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pembrolizumab' target='_blank'>NCI Drug Dictionary: Pembrolizumab</a> </li></ul>
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420

NEAREST SITE: 2299 miles
Levine Cancer Institute
Charlotte,NC

VISITS: 1 visit every 2 weeks, ongoing

PHASE: I-II

NCT ID: NCT03964532

Talazoparib and Avelumab for Advanced Breast Cancer (TALAVE)

TALAVE: A Pilot Trial of Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of talazoparib (Talzenna®) when it is used along with avelumab (Bavencio®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have not already received a PARP inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, every 2 weeks, starting 1 month after Talazoparib</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talzenna is a type of targeted therapy called a PARP inhibitor. It is approved to treat patients with an inherited BRCA mutation who have advanced HER2-negative breast cancer. </li> <li class="seamTextUnorderedListItem">Bavencio is a type of immunotherapy called a PD-L1 inhibitor. It is approved to treat certain types of lung cancer. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03964532' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-talazoparib-gbrcam-her2-negative-locally-advanced-or-metastatic-breast-cancer' target='_blank'>FDA: FDA approves talazoparib to treat some advanced breast cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.practiceupdate.com/content/avelumab-is-clinically-active-and-safe-in-advancedmetastatic-breast-cancer/60403' target='_blank'>PracticeUpdate: Avelumab Is Clinically Active and Safe in Advanced/Metastatic Breast Cancer</a> </li></ul>
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421

NEAREST SITE: 2299 miles
Roswell Park Cancer Institute
Buffalo,NY

VISITS: 3 visits a week for 3 months, then every 2 weeks for 2 months

PHASE: I

NCT ID: NCT04081389

Chemokine Modulation and Chemotherapy Before Surgery for Stage I-III Triple Negative Breast Cancer

Phase I Clinical Trial Assessing the Combination of Chemokine Modulation With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of using chemokine modulation therapy--celecoxib (Celebrex®), recombinant interferon alfa-2b, and rintatolimod (Ampligen)--and chemotherapy before surgery (neoadjuvant treatment).
Who is this for?
People with stage I, stage II, or stage III triple negative (ER-, PR-, HER2-) breast cancer who are scheduled to have surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following for 3 months: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Celecoxib (Celebrex®), by mouth, twice daily</li> <li class="seamTextUnorderedListItem">Recombinant interferon alfa-2b, by IV, 3 times a week</li> <li class="seamTextUnorderedListItem">Rintatolimod, by IV, 3 times a week</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) by IV, once a week</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">1 to 3 weeks after your last dose of paclitaxel, you will receive the following for 2 months:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doxorubicin and cyclophosphamide, by IV, once every 2 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemokines are molecules that help to enhance the immune system. </li> <li class="seamTextUnorderedListItem">Chemokine modulation therapy may make chemotherapy more effective.</li> <li class="seamTextUnorderedListItem">The chemotherapy drugs used in this study are doxorubicin (adriamycin) and cyclophosphamide (Cytoxan). Both are used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04081389' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/recombinant-interferon-alfa-2b' target='_blank'>NCI A to Z List of Cancer Drugs: Recombinant Interferon Alfa-2b</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/rintatolimod' target='_blank'>NCI Drug Dictionary: Rintatolimod</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/sabcs-2017/dr-coombes-on-intriguing-results-with-celecoxib-in-breast-cancer' target='_blank'>OncLive (Video): Dr. Coombes on Intriguing Results With Celecoxib in Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancernetwork.com/nccn/treatment-triple-negative-breast-cancer-slowly-moving-forward' target='_blank'>Cancer Network: Treatment for Triple-Negative Breast Cancer Slowly Moving Forward</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.frontiersin.org/articles/10.3389/fimmu.2019.00379/full' target='_blank'>Journal Article: Chemokines and Chemokine Receptors, New Targets for Cancer Immunotherapy</a> </li></ul>
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422

NEAREST SITE: 2314 miles
Wake Forest University Health Sciences
Winston-Salem,NC

VISITS: 9 visits over 3 months

PHASE: NA

NCT ID: NCT03505671

Acupuncture for Neuropathy (Hand/Foot Pain) Caused by Chemo for Stage I-III Breast Cancer

Acupuncture for Chemotherapy-Induced Peripheral Neuropathy Among Breast Cancer Patients Scientific Title

Purpose
To see if acupuncture can help reduce pain from peripheral neuropathy.
Who is this for?
Women with stage I, II or III breast cancer and currently receiving a taxane-based chemotherapy either before surgery (neoadjuvant therapy) or after surgery (adjuvant therapy). You must also have begun to develop peripheral neuropathy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">8 acupuncture treatments (45 minutes) over 2.5 months</li> <li class="seamTextUnorderedListItem">Follow-up visit at 3 months </li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care</li> <li class="seamTextUnorderedListItem">Follow-up visit at 3 months </li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Peripheral neuropathy--pain and numbness in the hands and feet--is a common side effect of chemotherapy regimens that include a taxane. </li> <li class="seamTextUnorderedListItem">This study is designed to see if acupuncture can help reduce this type of pain.</li> <li class="seamTextUnorderedListItem">Acupuncture is a type of Chinese medicine that involves inserting hair-thin needles into specific points on the body.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03505671' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/peripheral-neuropathy.html' target='_blank'>American Cancer Society: Peripheral Neuropathy Caused by Chemotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medscape.com/viewarticle/755026' target='_blank'>Medscape: Acupuncture Soothes Chemo-Induced Neuropathic Pain</a> </li></ul>
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423

NEAREST SITE: 2314 miles
Wake Forest University Health Sciences
Winston-Salem,NC

VISITS: Coincides with standard surgery

PHASE: NA

NCT ID: NCT03796273

Ketoconazole Before Surgery For Breast Cancer Brain Metastases

tGLI1 as a Therapeutic Target in Brain Metastases: A Window of Opportunity Study Scientific Title

Purpose
To study the anti-cancer activity, safety, and effects (good and bad) of the anti-fungal drug ketoconazole when it is given before surgery.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the brain.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ketoconazole, by mouth, once daily, for 4 days before surgery</li> <li class="seamTextUnorderedListItem">Surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ketoconazole is an antifungal drug that may be able to block a protein called tGLI1. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of brain tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03796273' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ketoconazole' target='_blank'>NCI Drug Dictionary: Ketoconazole</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/types/recur_metast/treat_metast/options/local/brain' target='_blank'>Breastcancer.org: Brain Metastasis Local Treatments</a> </li></ul>
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424

NEAREST SITE: 2352 miles
University of Rochester
Rochester,NY

VISITS: 1 visit a week, for 2 months

PHASE: NA

NCT ID: NCT03045289

Plant-Based Nutrition for Women with Metastatic Breast Cancer

Whole-Food, Plant-Based Nutrition Among Women With Metastatic Breast Cancer: A Pilot Study of Recruitment, Retention, and Preliminary Changes in Biomarkers and Symptoms. Scientific Title

Purpose
To explore the feasibility of conducting a study looking at the effect of a plant-based diet in women with stable metastatic breast cancer.
Who is this for?
Women with stable stage IV metastatic breast cancer who have had at least one imaging test (CT scan, bone scan, or PET/CT) within the last 6 months. You must currently be receiving systemic anti-cancer therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will randomly be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3 meals daily, delivered to your home, for 2 months</li> <li class="seamTextUnorderedListItem">1 office visit, weekly</li> <li class="seamTextUnorderedListItem">Multivitamin, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Maintain current food intake</li> <li class="seamTextUnorderedListItem">Multivitamin, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study will also provide preliminary data on the effect of plant-based nutrition on cancer prognosis and overall health.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03045289' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/20070321b' target='_blank'>Breastcancer.org: Plant-Based Diet May Decrease Risk</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancer.ucsf.edu/_docs/crc/nutrition_breast.pdf' target='_blank'>UCSF Cancer Center: Nutrition & Breast Cancer (pdf file)</a> </li></ul>
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425

NEAREST SITE: 2352 miles
University of Rochester
Rochester,NY

VISITS: 5 visits over 3-5 months

PHASE: NA

NCT ID: NCT03137095

Memory Problems During Chemotherapy in Patients with Stage I-III Breast Cancer

Longitudinal Pilot Mechanistic Study of the Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients and Non-Cancer Control Participants Scientific Title

Purpose
To see if and how your cognitive functioning skills, like memory and concentration, change as you receive chemotherapy.
Who is this for?
Women who have been recently diagnosed with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following over 3-5 months: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3 computerized and paper-based cognitive tests during chemotherapy and 1 month after completion of chemotherapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers will give you cognitive tests during your chemotherapy treatment and one month after you have completed treatment.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03137095' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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426

NEAREST SITE: 2352 miles
University of Rochester NCORP Research Base
Rochester,NY

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT03367572

Combinations of Antiemetics for Reducing Chemotherapy-Induced Nausea and Vomiting

Treatment of Refractory Nausea Scientific Title

Purpose
To study which combination of antiemetic drugs is most effective in reducing nausea and vomiting that often occur in patients receiving chemotherapy.
Who is this for?
Women diagnosed with breast cancer but who have not yet started chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Netupitant/palonosetron hydrochloride, by mouth, within 1 hour prior to receiving chemotherapy, on day 1 </li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, within 30 minutes prior to chemotherapy, days 1-4 </li> <li class="seamTextUnorderedListItem">Placebo, by mouth, every 8 hours with chemotherapy, days 1-4 </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Netupitant/palonosetron hydrochloride, by mouth, within 1 hour prior to receiving chemotherapy, on day 1 </li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, within 30 minutes prior to chemotherapy, days 1-4 </li> <li class="seamTextUnorderedListItem">Prochlorperazine and placebo, by mouth, every 8 hours with chemotherapy, days 1-4 </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Netupitant/palonosetron hydrochloride, by mouth, within 1 hour prior to receiving chemotherapy, on day 1 </li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, within 30 minutes prior to chemotherapy, days 1-4 </li> <li class="seamTextUnorderedListItem">Olanzapine and placebo, by mouth, every 8 hours with chemotherapy, days 1-4</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The antiemetic drugs being used in this study are netupitant/palonsetron hydrochloride (Akynzeo), dexamethasone (Decadrone), prochlorperazine, and olanzapine (Zyprexa).</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03367572' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/updated-asco-guidelines-on-antiemetics' target='_blank'>ASCO: Guidelines to treat nausea and vomiting</a> </li></ul>
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427

NEAREST SITE: 2352 miles
University of Rochester Medical Center
Rochester,NY

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03473639

Entinostat & Capecitabine for Stage II, Stage III and Metastatic HER2 Negative Breast Cancer

A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant Therapy Scientific Title

Purpose
To study the safety and effects (good and bad) of using a combination of the targeted therapy entinostat with the chemotherapy capecitabine (Xeloda®).
Who is this for?
People with stage II, stage III, or metastatic (stage IV) HER2 negative (HER2-) breast cancer who had chemotherapy that included a taxane or anthracycline before they had surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Entinostat, by mouth, once a week, for 6 months</li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, twice a day, for 2 out of every 3 weeks, for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">For stage IV patients, treatment is received for as long as benefit is shown</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Entinostat is an investigational type of targeted therapy called an HDAC inhibitor. </li> <li class="seamTextUnorderedListItem">Xeloda is a chemotherapy drug used to treat metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03473639' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/capecitabine.aspx' target='_blank'>Chemocare: Capecitabine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/entinostat' target='_blank'>NCI Drug Dictionary: Entinostat</a> </li></ul>
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428

NEAREST SITE: 2371 miles
University of Florida Proton Therapy Institute
Jacksonville,FL

VISITS: 2 visits over 1 year

PHASE: NA

NCT ID: NCT02199366

Using MRI of the Heart to Study Effects of Radiation Therapy for Left-Sided Breast Cancer

Prospective Pilot Study of Early Markers of Radiation-Induced Cardiac Injury in Patients With Left-Sided Breast Cancer Receiving Photon or Proton Therapy Scientific Title

Purpose
To study whether MRI scans of the heart can identify changes in heart function that develop after radiation therapy.
Who is this for?
People who are scheduled to receive radiation therapy for a stage I, stage II, or stage III, left-sided breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 MRI scans of the heart, before radiation therapy and within 1 year after completion of radiation therapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">People who receive radiation therapy to treat breast cancer in their left breast are at risk of developing heart problems. </li> <li class="seamTextUnorderedListItem">Magnetic Resonance Imaging (MRI) scans produce detailed images of the inside of the body.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02199366' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/testing/types/mri' target='_blank'>BreastCancer.org: MRI</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/20070809b' target='_blank'>BreastCancer.org: Radiation and Heat Problem</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation/when_appropriate' target='_blank'>BreastCancer.org: Radiation</a> </li></ul>
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429

NEAREST SITE: 2376 miles
University of Virginia
Charlottesville,VA

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT02400658

Intraoperative Radiation Therapy for Women Age 45 and Over with Stage I-III Breast Cancer

A Prospective Single-Arm Phase II Study To Investigate The Efficacy Of Single-Fraction Intraoperative Radiation Treatment Using A Multi-Lumen Balloon Applicator And In-Room CT Imaging For The Treatment Of Early-Stage Breast Cancer Scientific Title

Purpose
To study the anti-cancer activity and effects (good and bad) of giving a single high-dose of radiation therapy during surgery instead of many lower-doses of radiation therapy after surgery.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who are 45 or older and planning to have breast conserving surgery (lumpectomy)    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiation therapy (IORT) during surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast conserving surgery (lumpectomy) followed by radiation therapy is a standard treatment for early-stage breast cancer.</li> <li class="seamTextUnorderedListItem">Intraoperative radiation therapy (IORT) delivers a high dose of radiation guided by CT-imaging during surgery to the area in the breast where the tumor was removed.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02400658' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation/types/intraoperative' target='_blank'>Breastcancer.org: IORT</a> </li></ul>
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430

NEAREST SITE: 2376 miles
University of Virginia
Charlottesville,VA

VISITS: 1 visit every 3 weeks, up to 2 years

PHASE: I

NCT ID: NCT03237572

Focused Ultrasound and Pembrolizumab in Advanced Breast Cancer

Focused Ultrasound Therapy to Augment Antigen Presentation and Immune-Specificity of Checkpoint Inhibitor Therapy With Pembrolizumab in Metastatic Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of receiving High-Intensity Focused Ultrasound (HIFU), a method of killing cancer cells with sound waves, along with the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who no standard treatments available. You must also have a tumor in the breast, chest wall, or armpit.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High Intensity Focused Ultrasound (HIFU), once</li> <li class="seamTextUnorderedListItem">followed by, pembrolizumab (Keytruda®), by IV, every 3 weeks, for 9 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, for 9 weeks</li> <li class="seamTextUnorderedListItem">after your first dose of pembrolizumab, then High Intensity Focused Ultrasound (HIFU), once</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HIFU is a treatment that works to kill cancer cells with high frequency sound waves. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. It stimulates the body's immune system to fight cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03237572' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/other/high-intensity-focused-ultrasound-hifu' target='_blank'>Cancer Research UK: High-Intensity Focused Ultrasound</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda</a> </li></ul>
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431

NEAREST SITE: 2376 miles
University of Virginia
Charlottesville,VA

VISITS: 1-2 visits a week for 7 weeks, may require hospitalization

PHASE: I-II

NCT ID: NCT03272334

A T-Cell Immunotherapy (HER2 BATs) and Keytruda for Women With Metastatic Breast Cancer

A Phase I/II Study of Anti-CD3 x Anti-HER2/Neu (Her2Bi) Armed Activated T Cells (ATC) and Pembrolizumab Combination Therapy in Women With Metastatic Breast Cancer Scientific Title

Purpose
To investigate the safety and effects (good and bad) of combining the PD-1 inhibitor Keytruda with an immunotherapy made from your T-cells.
Who is this for?
Women with metastatic (stage IV) breast cancer. You must have had two or more prior therapies (chemotherapy or hormonal) for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw for the collection of your white blood cells (leukapheresis), then 4 to 5 weeks later</li> <li class="seamTextUnorderedListItem">T-cell immunotherapy (HER2 BATs), by IV, 8 times over 6 weeks </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once during week 7</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw for the collection of your white blood cells (leukapheresis), then 4 to 5 weeks later</li> <li class="seamTextUnorderedListItem">T-cell immunotherapy (HER2 BATs), by IV, 8 times over 6 weeks </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, twice, during week 3-4 and week 7</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw for the collection of your white blood cells (leukapheresis), then 4 to 5 weeks later</li> <li class="seamTextUnorderedListItem">T-cell immunotherapy (HER2 BATs), by IV, 8 times over 6 weeks </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, three times, before BATs, during week 3-4 and week 7</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule. May require hospitalization</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">HER2 bispecific antibody armed T cells (BATs) are an experimental type of T-cell immunotherapy. </li> <li class="seamTextUnorderedListItem">The HER2 BATs will be made by collecting white blood cells from your body. Your white blood cells will then be modified in a lab so they can identify and attack cancer cells. These modified cells will then be infused back into your body.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03272334' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/her2bi-armed-activated-t-cells' target='_blank'>NCI Drug Dictionary: HER2Bi-armed ATCs</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839366/' target='_blank'>OncoImmunology: HER2 BATs</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com/?src=google&med=cpc&camp=Keytruda+Pan+Tumor_Brand_BRND_NA_ENGM_EXCT_TEXT_NA&adgrp=Brand+Keyword_General&kw=keytruda&utm_kxconfid=sq7irm3mh&gclid=CjwKCAjwt-L2BRA_EiwAacX32ZWZ-hf-RSddVt1Y8_oFJEJzejiyhC9eCFhl1JG4WlqWBf2Aq3rrXhoCf7AQA' target='_blank'>Merck Oncology Drug Information Page: Keytruda®</a> </li></ul>
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432

NEAREST SITE: 2376 miles
University of Virginia
Charlottesville,VA

VISITS: At least 11 visits over 3-4 months; may require hospitalization

PHASE: I

NCT ID: NCT03661424

T-Cell Immunotherapy for Women with Breast Cancer-Related Leptomeningeal Metastases

A Phase I Study of Anti-CD3 x Anti-Her2/Neu (Her2Bi) Armed Activated T Cells (ATC) in Patients With Breast Cancer Leptomeningeal Metastases Scientific Title

Purpose
To study the safety and effects (good and bad) of an immunotherapy made from T-cells taken from your body that have been treated to go after cancer cells.
Who is this for?
Women with metastatic (stage IV) breast cancer that has spread to the membranes surrounding the brain and spinal cord. This is called leptomeningeal metastasis.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw for the collection of your white blood cells (leukapheresis)</li> <li class="seamTextUnorderedListItem">Surgery to place a device (similar to a chemotherapy port) under your scalp, 2 weeks after the blood draw</li> <li class="seamTextUnorderedListItem">Methotrexate, by IV, at least once</li> <li class="seamTextUnorderedListItem">T-cell immunotherapy (HER2 BATs), by IV, weekly, for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 brain MRIs (before the first and after the eighth infusion)</li> <li class="seamTextUnorderedListItem">Blood draws, before, during and after treatment</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HER2 BATs is the name for the T-cell immunotherapy you will receive. </li> <li class="seamTextUnorderedListItem">BATs is short for bi-specific antibody armed T-cells. </li> <li class="seamTextUnorderedListItem">Although trastuzumab (Herceptin®) is used to make the BATs, women do not need to have HER2+ breast cancer to take part in the study.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03661424' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.drsusanloveresearch.org/impatient-science/understanding-immunology' target='_blank'>Dr. Susan Love Foundation: Cancer Immunology</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1500672' target='_blank'>OncoImmunology Journal: BATs</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/her2bi-armed-activated-t-cells' target='_blank'>NCI Drug Dictionary: HER2Bi-armed ATCs</a> </li></ul>
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433

NEAREST SITE: 2376 miles
University of Virginia
Charlottesville,VA

VISITS: 1 visit every 2-3 weeks for 6 months

PHASE: II

NCT ID: NCT04038489

Aspirin, Tamoxifen & AC-T Chemotherapy Before Surgery for ER+, HER2- Breast Cancer

COX Inhibition and Biomarkers of Response During Neoadjuvant Chemoendocrine Therapy for Estrogen Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative Stage I-III Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of adding aspirin and tamoxifen to a standard chemotherapy regimen used before surgery to treat ER+, HER2- early-stage breast cancer.
Who is this for?
People with estrogen receptor positive (ER+), HER2 negative (HER2-) stage I, stage II or stage III breast cancer and not have had any treatment for your breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aspirin, by mouth, daily, for 6 months</li> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®), by mouth, daily, for 6 months</li> <li class="seamTextUnorderedListItem">Doxorubicin (Adriamycin®), by IV, every 2 or 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®), by IV, every 2 or 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Followed by Paclitaxel (Taxol®), by IV, every 1-3 weeks depending on the dose, for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aspirin reduces pain and swelling by blocking an enzyme called COX2. Studies suggest blocking this enzyme could also help keep cancer cells from growing. </li> <li class="seamTextUnorderedListItem">Tamoxifen is a hormone therapy used to treat hormone-sensitive breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04038489' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-1082-3/aspirin-oral/aspirin-oral/details' target='_blank'>WebMD: Aspirin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/breast-cancer/news/20170501/low-dose-aspirin-may-lower-risk-for-common-breast-cancer-by-20-percent#1' target='_blank'>WebMD: Low-Dose Aspirin May Lower Breast Cancer Risk</a> </li><li class='seamTextUnorderedListItem'><a href='https://ecancer.org/en/news/15340-low-dose-aspirin-is-associated-with-a-reduced-risk-of-metastases-and-increased-survival-in-cancer' target='_blank'>eCancer: Low-dose aspirin is associated with a reduced risk of metastases and increased survival in cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1065-0' target='_blank'>Breast Cancer Research: No association between low-dose aspirin use and breast cancer outcomes overall</a> </li></ul>
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434

NEAREST SITE: 2376 miles
University of Virginia
Charlottesville,VA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04116320

FUSA Alone or With Immunotherapy in Advanced Breast Cancer

Pilot Evaluation of Focused Ultrasound Ablation and Focused Ultrasound Ablation Plus PD-1 Antibody Blockade in Advanced Solid Tumors Scientific Title

Purpose
To compare the safety and effects (good or bad) of Focused Ultrasound Ablation (FUSA) when it is used alone, with a PD-1 inhibitor, with imiquimod (Aldara®), or with both a PD-1 inhibitor and imiquimod (Aldara®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 4 groups depending on your diagnosis: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Focused Ultrasound Ablation (FUSA), once</li> <li class="seamTextUnorderedListItem">PD-1 inhibitor therapy, by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Focused Ultrasound Ablation (FUSA), once</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Focused Ultrasound Ablation (FUSA), once</li> <li class="seamTextUnorderedListItem">PD-1 inhibitor therapy, by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Imiquimod (Aldara®), cream applied to skin</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Focused Ultrasound Ablation (FUSA), once</li> <li class="seamTextUnorderedListItem">Imiquimod (Aldara®), cream applied to skin</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">FUSA (Focused Ultrasound Ablation) uses ultrasound waves to kill cancer cells. It may also trigger your immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">PD-1 inhibitors are a type of immunotherapy called a checkpoint inhibitor. They stimulate the body's immune system to fight cancer cells. </li> <li class="seamTextUnorderedListItem">Imiquimod (Aldara®) is a cream-based immunotherapy. It is used to treat skin cancer and other types of skin disorders. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04116320' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://fusfoundation.org/diseases-and-conditions/oncological/breast-cancer' target='_blank'>Focused Ultrasound Foundation: Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.researchgate.net/figure/Ultrasound-guided-focused-ultrasound-ablation-device-Echopulse-Theraclion-VTU_fig1_268788751' target='_blank'>ResearchGate: Echopulse</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/imiquimod' target='_blank'>NCI Drug Dictionary: Imiquimod</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://oncologypro.esmo.org/Oncology-News/OncologyNews-archives-2017/Topical-Imiquimod-Regimen-Shows-Promise-For-Chest-Wall-Cutaneous-Breast-Cancer-Metastases' target='_blank'>ESMO: Topical Imiquimod Regimen Shows Promise For Chest Wall, Cutaneous Breast Cancer Metastases</a> </li></ul>
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435

NEAREST SITE: 2383 miles
Mayo Clinic in Florida
Jacksonville,FL

VISITS: 3 visits a month

PHASE: NA

NCT ID: NCT04249167

Cryoablation, Immunotherapy, & Chemotherapy For Advanced Triple Negative & ER-Low Breast Cancer That Tests Positive For PD-L1

Cryoablation and Anti-PD-L1 Immunotherapy for Triple Negative Breast Cancer (TNBC) Scientific Title

Purpose
To study the safety and effects (good and bad) of cryoablation followed by treatment with atezolizumab (Tecentriq®) and nab-paclitaxel (Abraxane®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer whose tumor tests positive for PD-L1.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation of tumor</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 2 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, every week (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Cryoablation uses extreme cold to kill cancer cells. </li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is a type of immunotherapy called a PD-L1 inhibitor. It works by blocking the PD-L1 (programmed death-ligand 1) protein.</li> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is approved for use with the chemotherapy drug Abraxane® to treat advanced, triple-negative, PD-L1-positive breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04249167' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayo.edu/research/clinical-trials/cls-20477447' target='_blank'>Mayo Clinic: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2019/atezolizumab-triple-negative-breast-cancer-fda-approval' target='_blank'>NCI Cancer Currents Blog: Atezolizumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Protein-bound_paclitaxel' target='_blank'>Wikipedia: Protein-bound Paclitaxel</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopost.com/issues/october-10-2019/atezolizumab-for-triple-negative-breast-cancer/' target='_blank'>ASCO: Atezolizumab for PD-L1–Positive Locally Advanced or Metastatic Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.frontiersin.org/articles/10.3389/fimmu.2019.02283/full' target='_blank'>Frontiers in Immunology: Cryoablation and Immunotherapy</a> </li></ul>
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436

NEAREST SITE: 2384 miles
Duke University Medical Center
Durham,NC

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02707471

Treatment Adherence for Stage I-III Breast Cancer Patients Taking a Hormone Therapy Drug

Improving Well-Being for Breast Cancer Patients Taking Adjuvant Endocrine Therapy Scientific Title

Purpose
To determine which type of phone counseling session helps women continue to take their anti-estrogen drugs daily.
Who is this for?
Women with stage I, stage II, and stage III hormone receptor positive (ER+ and/or PR+) breast cancer. You must also be planning on taking an anti-estrogen drug after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and undergo the following over 1.5 years: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">10 phone counseling sessions with a nurse </li> <li class="seamTextUnorderedListItem">Interactive voice messaging tailored to your medication-taking behavior </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">10 phone counseling sessions on general health education with a nurse</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will receive a smart medication bottle that records the time you take your drug and sends this information to the research team.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02707471' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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437

NEAREST SITE: 2384 miles
Duke University
Durham,NC

VISITS: At least 1 visit every month, ongoing

PHASE: II

NCT ID: NCT03167619

Durvalumab & Olaparib in Advanced Triple Negative Breast Cancer Treated with Chemotherapy

Phase II Multicenter Study of Durvalumab and Olaparib in Platinum tReated Advanced Triple Negative Breast Cancer (DORA) Scientific Title

Purpose
To compare the effects (good and bad) of using the targeted therapy olaparib (Lynparza®) alone or with an immunotherapy drug.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer, already treated with at least four cycles of a platinum-based chemotherapy, and who have had no more than two prior chemotherapies for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily</li> <li class="seamTextUnorderedListItem">Durvalumab (Imfizi®), by IV, once every month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lynparza is approved to treat HER2-negative metastatic breast cancer in patients who test positive for an inherited BRCA mutation. </li> <li class="seamTextUnorderedListItem">Lynparza is a PARP inhibitor, a drug that blocks the action of poly (ADP-ribose) polymerase, an enzyme that helps repair DNA. </li> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®) is a type of immunotherapy called a PD-L1 (programmed cell death ligand-1) inhibitor. </li> <li class="seamTextUnorderedListItem">It has been approved to treat certain other types of cancers, and its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03167619' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.imfinzi.com/stage-3-nsclc/about/how-imfinzi-works.html?source=imz_c_c_45&umedium=cpc&uadpub=google&ucampaign=2018imfinzidtcnsclcbranded_general&ucreative=branded_alone_ex&uplace=durvalumab&outcome=dtc&cmpid=1' target='_blank'>AstraZeneca Information Page: Imfinzi</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/durvalumab-improves-survival-in-stage-iii-nsclc' target='_blank'>Oncolive: Durvalumab/Olaparib Combo Is Active in BRCA-Mutated Metastatic Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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438

NEAREST SITE: 2385 miles
Duke Cancer Center
Durham,NC

VISITS: 1 visit

PHASE: II

NCT ID: NCT02482376

Radiation Therapy Before Surgery for ER+, HER2- DCIS or Stage I Breast Cancer

A Phase II Preoperative Single-Fraction Partial Breast Radiotherapy in Early Stage Breast Cancer: Analysis of Pathologic Response Scientific Title

Purpose
To compare cancer cells found in a breast biopsy done before the radiation treatment is given with cancer cells removed during breast conserving surgery (lumpectomy).
Who is this for?
Women with estrogen receptor positive, HER2 negative DCIS or stage I breast cancer. You must be at least 60 years of age or. if you are between 50 and 59 years of age, have a low Oncotype DX score (0-17)    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 radiation treatment, 6 weeks before surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving radiation before surgery allows researchers to study how cancer cells respond to radiation treatments. </li> <li class="seamTextUnorderedListItem">Stereotactic body radiation therapy (SBRT) is a type of radiation treatment that delivers a high dose of radiation directly to the tumor. This reduces the risk of damaging healthy breast tissue.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02482376' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02482376?term=NCT02482376&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.radiologyinfo.org/en/info.cfm?pg=stereotactic' target='_blank'>RadiologyInfo.org: SBRT</a> </li></ul>
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439

NEAREST SITE: 2385 miles
Duke University Medical Center
Durham,NC

VISITS: 1 visit

PHASE: NA

NCT ID: NCT03564782

PVSRIPO Vaccine in Stage II, III and IV Triple Negative Breast Cancer

Examining Oncolytic Poliovirus Bioactivity in Tumor Tissue After Intratumoral Administration of PVSRIPO in Women With Triple Negative Breast Cancer Scientific Title

Purpose
To look at the safety, effects (good and bad) and best dose of an experimental immunotherapy called PVSRIPO.
Who is this for?
Women with stage II-III triple negative breast cancer (ER-, PR- and HER2-) that has not responded to other treatment options or who has metastatic (stage IV) TNBC with a local recurrence on the chest wall.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVSRIPO, by injection, one time </li> <li class="seamTextUnorderedListItem">Surgery as planned</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVSRIPO is a vaccine made out of a modified poliovirus. </li> <li class="seamTextUnorderedListItem">The vaccine uses the virus to get the immune system to kill cancer cells. </li> <li class="seamTextUnorderedListItem">You can not get polio from the vaccine.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03564782' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/recombinant-oncolytic-poliovirus-pvs-ripo' target='_blank'>Cancer.gov: Recombinant oncolytic poliovirus PVS-RIPO</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.istarioncology.com/our-science/pvs-ripo/' target='_blank'>Sponsor site: PVSRIPO</a> </li><li class='seamTextUnorderedListItem'><a href='http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e12641' target='_blank'>Journal of Clinical Oncology: Recombinant oncolytic poliovirus combined with checkpoint blockade for breast cancer therapy</a> </li></ul>
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440

NEAREST SITE: 2385 miles
Duke University
Durham,NC

VISITS: Visits every 2 weeks for 6 weeks and/or every 3 weeks for 4 months

PHASE: II

NCT ID: NCT03632941

A Cancer Vaccine and Pembrolizumab for Advanced HER2 Positive Breast Cancer

A Phase II Randomized Study to Evaluate the Immunologic and Antitumor Activity of Concurrent VRP-HER2 Vaccination and Pembrolizumab for Patients With Advanced HER2-overexpressing Breast Cancer Scientific Title

Purpose
To compare the safety and effects (good and bad) of using the investigational tumor vaccine VRP-HER2 alone, to pembrolizumab (Keytruda®) alone, and to both treatments together.
Who is this for?
People with recurrent or advanced (some stage III) or metastatic (stage IV) HER2 positive breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">VRP-HER2 (AVX901), by injection, once every 2 weeks, for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks, for 4 months </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">VRP-HER2 (AVX901), by injection, once every 2 weeks, for 6 weeks</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks, for 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures: 2 biopsies</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The VRP-HER2 cancer vaccine is designed to activate the immune system to go after HER2 positive cancer cells. </li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PDL-1 inhibitor. It is approved to treat certain types of cancers. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03632941' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/her2-ecdtm-virus-like-replicon-particles-vaccine-avx901' target='_blank'>NCI Drug Dictionary: HER2 ECD+TM virus-like replicon particles vaccine AVX901</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645504/' target='_blank'>Frontiers Endocrinology: Breast Cancer Vaccines: New Insights</a> </li></ul>
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441

NEAREST SITE: 2385 miles
Duke University Medical Center
Durham,NC

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04197999

Your Hormone Therapy & GMI-1359 in Hormone Positive Metastatic Breast Cancer

A Phase 1b, Single and Multiple Dose, Open-Label Trial of Intravenous GMI-1359 in HR+ Metastatic Breast Cancer Subjects Scientific Title

Purpose
To study the safety and effects (good and bad) of the experimental drug GMI-1359 when it is used along with a hormone therapy you are currently receiving and responding to.
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+) breast cancer, on a hormone therapy, and not receiving a HER2 targeted therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Your current hormone therapy</li> <li class="seamTextUnorderedListItem">GMI-1359, by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GMI-1359 is an experimental therapy that targets two proteins--E-selectin and CXCR4--that help tumors spread to other parts of the body. </li> <li class="seamTextUnorderedListItem">Researchers think using GMI-1359 along with hormone therapy will make the hormone therapy more effective.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04197999' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://glycomimetics.com/pipeline/programs/gmi-1359/' target='_blank'>Drug Company Information Page: GMI-1359</a> </li></ul>
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442

NEAREST SITE: 2395 miles
H. Lee Moffitt Cancer Center and Research Institute
Tampa,FL

VISITS: 3 visits a week for 3 months

PHASE: I-II

NCT ID: NCT03112590

Actimmune with Taxol, Herceptin & Perjeta for HER2+ Breast Cancer

A Phase I-II Study of Interferon-gamma Plus Weekly Paclitaxel, Trastuzumab and Pertuzumab in Patients With HER-2 Positive Breast Cancer Scientific Title

Purpose
To evaluate the safety, effects (good and bad) and best dose of Actimmune® (IFN-γ 1b), an immunotherapy, when it is used along with paclitaxel (Taxol®), trastuzumab (Herceptin®), and pertuzumab (Perjeta®).
Who is this for?
People with HER2 positive breast cancer. Phase 1 is for advanced (some stage III) or metastatic (stage IV) breast cancer; Phase II is for stage II or stage III breast cancer."    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following for 3 months: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Phase I: Advanced breast cancer</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Actimmune® (IFN-γ 1b), by injection, 3 times a week</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks </li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Phase II: Stage II-III breast cancer</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Actimmune® (IFN-γ 1b), by injection, 3 times a week</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks </li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by surgery</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Interferon-gamma (IFN-?) is a protein produced by the body's immune cells to prevent infection.</li> <li class="seamTextUnorderedListItem">Actimmune is a protein made in the laboratory that is similar to interferon-gamma (IFN-?). </li> <li class="seamTextUnorderedListItem">Taxol, Herceptin and Perjeta are standard of care treatments for HER2+ advanced breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03112590' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=784898' target='_blank'>NCI: Actimmune (IFN-γ 1b)</a> </li></ul>
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443

NEAREST SITE: 2395 miles
H. Lee Moffitt Cancer Center and Research Institute
Tampa,FL

VISITS: 12-15 visits over 2 years

PHASE: NA

NCT ID: NCT03387553

HER2 Vaccine Before and After Surgery For HER2-Positive Breast Cancer

A Pilot Study Utilizing a HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+ Breast Cancer Scientific Title

Purpose
To determine the safety, effects (good and bad) and best schedule for using a personalized HER2 immunotherapy vaccine.
Who is this for?
People with HER2 positive and hormone receptor negative (ER-and PR-) stage II or stage III breast cancer who intend to be treated with TCH-P chemotherapy (Taxotere®, Carboplatin, Herceptin®, Perjeta®) before surgery.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups and receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis"><u>Group 1: Vaccine given once a week</u></i> </p> <p class="seamTextPara"> Before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dendritic cell vaccine (DC1), by injection, once a week, for 3 weeks</li> <li class="seamTextUnorderedListItem">followed by TCH-P chemotherapy (Taxotere®, Carboplatin, Herceptin®, Perjeta®), by IV, every 3 weeks for 4-5 months</li> <li class="seamTextUnorderedListItem">Booster vaccine, by injection, 1 week before surgery</li> </ul> <p class="seamTextPara"> After surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Booster vaccine, by injection, every 6 months for 18 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis"><u>Group 2: Vaccine given twice a week</u></i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Same as above with the DC1 vaccine given twice a week, for 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study will investigate the safety, effects (good and bad) and best schedule for using a personalized HER2 immunotherapy vaccine. </li> <li class="seamTextUnorderedListItem">Each study participant receives a vaccine made from his or her own white blood cells. </li> <li class="seamTextUnorderedListItem">The white blood cells, called dendritic cells, are removed from your body, processed in a lab so that they will see and go after HER2-positive cancer cells, and then will be injected as a vaccine before and after your breast cancer surgery.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03387553' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youtube.com/watch?v=-gJfkmv5ZIs' target='_blank'>Dr. Susan Love Research Foundation: Breast Cancer Vaccines</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedirect.com/science/article/abs/pii/S1526820911703330' target='_blank'>Clinical Breast Cancer: HER2 Dendritic Cell Vaccines</a> </li></ul>
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444

NEAREST SITE: 2395 miles
H. Lee Moffitt Cancer Center and Research Institute
Tampa,FL

VISITS: 1 visit every 4 weeks, ongoing

PHASE: I

NCT ID: NCT03807765

Stereotactic Radiation and Nivolumab for Metastatic Breast Cancer with Brain Metastases

Phase Ib Study of Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases Scientific Title

Purpose
To study the safety and effects of using stereotactic radiosurgery to treat brain metastases in patients who have received nivolumab (Opdivo®).
Who is this for?
People with metastatic (stage IV) breast cancer with brain metastases not previously treated with whole brain radiation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 4 weeks</li> <li class="seamTextUnorderedListItem">Stereotactic Radiosurgery (SRS), once, during the week after the first dose of Nivolumab</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery is a type of very targeted radiation therapy. </li> <li class="seamTextUnorderedListItem">Opdivo is a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03807765' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.radiologyinfo.org/en/info.cfm?pg=stereotactic' target='_blank'>RadiologyInfo.org: Stereotactic Radiosurgery (SRS)</a> </li></ul>
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445

NEAREST SITE: 2395 miles
H. Lee Moffitt Cancer Center and Research Institute
Tampa,FL

VISITS: 1 visit every month, for 6 months

PHASE: II

NCT ID: NCT03874325

Aromatase Inhibitor & Durvalumab Before Surgery in Postmenopausal Women

A Phase II Trial With Safety Run-in of Neoadjuvant Therapy With an Aromatase Inhibitor in Combination With Durvalumab (MEDI4736) in Postmenopausal Patients With Hormone-Receptor-Positive Breast Cancer Scientific Title

Purpose
To study the safety and effects of durvalumab (Imfinzi®) when it is given along with an aromatase inhibitor.
Who is this for?
Postmenopausal women with HER2-negative and ER-positive stage II or stage IIIA breast cancer who have not yet had surgery or other cancer treatments.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (Imfinzi®), by IV, once a month, for 6 months</li> <li class="seamTextUnorderedListItem">Anastrozole (Arimidex®) or Letrozole (Femara®) or Exemestane (Aromasin®), by mouth, daily for 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Treatment given before surgery is called neoadjuvant therapy. It allows the researchers to study the effect the treatment has on the cancer cells. </li> <li class="seamTextUnorderedListItem">Imfinzi is a type of immunotherapy called a PD-1 inhibitor. It is approved to treat certain types of lung cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Anastrozole (Arimidex®), letrozole (Femara®) and exemestane (Aromasin®) are aromatase inhibitors used to treat HR-positive breast cancer in postmenopausal women.</li> <li class="seamTextUnorderedListItem">You will begin treatment with Arimidex. If you develop side effects, you will receive Femara or Aromasin instead.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03874325' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/durvalumab.aspx' target='_blank'>Chemocare.com: Durvalumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li></ul>
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446

NEAREST SITE: 2406 miles
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill,NC

VISITS: 3 visits

PHASE: NA

NCT ID: NCT01000883

Identifying Tumor Markers That Predict Treatment Response in Women with Advanced Disease

Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior Scientific Title

Purpose
To collect biological specimens from patients with locally advanced or metastatic breast cancer along with clinical information about their treatment, and to identify tumor markers that predict treatment response in women with advanced disease
Who is this for?
Women with stage III and metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will undergo the following at diagnosis, during chemotherapy treatment, and prior to surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Core biopsy</li> <li class="seamTextUnorderedListItem">Blood sampling</li> <li class="seamTextUnorderedListItem">Assessment of tumor markers</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers are trying to find ways to determine which tumors will respond to which treatments. </li> <li class="seamTextUnorderedListItem">Studying tumor tissue and blood samples from patients before and after cancer treatments may help researchers identify tumor markers that can guide treatment choices.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01000883' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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447

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda,MD

VISITS: Every 2 weeks for 1 year

PHASE: I-II

NCT ID: NCT02484404

MEDI4736 with Lynparza or Cediranib for Advanced Triple Negative Breast Cancer

Phase I/II Study of the Anti-Programmed Death Ligand-1 Antibody MEDI4736 in Combination With Olaparib or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of giving MEDI4736 and Lynparza together.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer for whom no currently available treatment exists. You must not have received more than three prior therapies for metastatic disease.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MEDI4736 (duryalumab), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MEDI4736 (duryalumab), by IV, every 2 weeks</li> <li class="seamTextUnorderedListItem">Cediranib, by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Durvalumab (MEDI4736) is an immunotherapy drug that works by blocking a protein called PD-L1 (programmed cell death ligand-1). Blocking this protein allows the body's immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of cancer drug called a PARP inhibitor. PARP inhibitors interfere with the cancer cells' DNA, making them more sensitive to chemotherapy. </li> <li class="seamTextUnorderedListItem">Lynparza is used to treat advanced ovarian cancer in women who have an inherited BRCA1/2 mutation.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02484404' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=740856' target='_blank'>NCI Drug Dictonary: MEDI4736</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=560191' target='_blank'>NCI Drug Dictonary: Olaparib</a> </li></ul>
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448

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda,MD

VISITS: Hospital stay for about 4 weeks

PHASE: II

NCT ID: NCT01174121

Individualized Immunotherapy for Metastatic Breast (and Other) Cancer

A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphocyte Depleting Regimen in Metastatic Cancers Plus the Administration of Pembrolizumab Scientific Title

Purpose
To study a new type of immunotherapy in which researchers take TILs from tumors, grow the ones that are most effective in fighting the cancer in the laboratory, and then give the cells back to the patient.
Who is this for?
People with metastatic (stage IV) breast cancer and have a tumor that can be surgically removed.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> All participants will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery to remove tumor sample used to grow the tumor infiltrating lymphocyte</li> <li class="seamTextUnorderedListItem">White blood cells-depleting preparative regimen</li> <li class="seamTextUnorderedListItem">Followed by tumor Infiltrating Lymphocytes, by IV</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tumor infiltrating lymphocytes (TILs) are the white blood cells that are found in tumors. </li> <li class="seamTextUnorderedListItem">The immune system has activated these cells to try to control the cancer's growth. </li> <li class="seamTextUnorderedListItem">This study is investigating a new type of immunotherapy in which researchers take TILs from tumors, grow the ones that are most effective in fighting the cancer in the laboratory, and then give the cells back to the patient. </li> <li class="seamTextUnorderedListItem">Previous studies using TIL in melanoma have shown effectiveness in shrinking the tumor. </li> <li class="seamTextUnorderedListItem">In this study, researchers will study the effectiveness of TIL in shrinking breast (and other) tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01174121' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT01174121' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.esmo.org/Conferences/Past-Conferences/ESMO-2014-Congress/News-Articles/The-Promise-of-Tumour-Infiltrating-Lymphocytes-for-Cancer-Treatment-and-as-Prognostic-Predictive-Indicators' target='_blank'>ESMO: Tumor Infiltrating Lymphocytes in Melanoma</a> </li></ul>
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449

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda,MD

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT00028340

Using Breast Duct Cells to Assess Cancer Risk

Characterization of High Risk Breast Duct Epithelium by Cytology, Breast Duct Endoscopy, and cDNA Gene Expression Profile Scientific Title

Purpose
To compare the ductal cells and tissue by using ductal lavage and ductal endoscopy in women who are at high risk for breast cancer, breast cancer survivors and healthy volunteers.
Who is this for?
Women with breast cancer or high risk of developing breast cancer, healthy volunteer can also join the trial.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> All participants will receive the following procedures: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ductal lavage to collect milk duct cells</li> <li class="seamTextUnorderedListItem">Ductal endoscopy to observe the structure of the duct</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Most breast cancers begin in the cells that line the milk ducts in the breast. </li> <li class="seamTextUnorderedListItem">Previous studies have identified certain changes in the ductal cells and breast tissue that are associated with an increased risk of developing breast cancer. </li> <li class="seamTextUnorderedListItem">Ductal lavage and ductal endoscopy are techniques that allow researchers to study the cells and fluid that line the breast duct.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00028340' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/testing/types/ductal' target='_blank'>breastcancer.org: Ductal Lavage</a> </li></ul>
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450

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD

VISITS: Hospital stay for at least 1 week; follow-up visits for 2 years

PHASE: I-II

NCT ID: NCT02830724

CAR T-Cell Immunotherapy for Metastatic Breast Cancer That Tests Positive for CD70

A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to Patients With CD70 Expressing Cancers Scientific Title

Purpose
To study the safety and effects (good and bad) of using a new type of CAR T-cell immunotherapy.
Who is this for?
People with metastatic (stage IV) breast cancer that tests positive for CD70 who have already received at least one standard therapy.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Hospital stay (at least 1-week):</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leukapheresis (blood draw for the collection of cells)</li> <li class="seamTextUnorderedListItem">Cyclophosphamide, by IV, once a day, for 2 days</li> <li class="seamTextUnorderedListItem">Fludarabine, by IV, once a day, for 5 days</li> <li class="seamTextUnorderedListItem">Aldesleukin, by IV, 3 times a day, for 3 days</li> <li class="seamTextUnorderedListItem">Anti-hCD70 CAR T-cells, by IV, one time</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Post-hospital stay:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Antibiotic for 6 months</li> <li class="seamTextUnorderedListItem">Repeat Leukapheresis (blood draw for the collection of cells)</li> <li class="seamTextUnorderedListItem">1-2 day hospital visits (for lab tests, imaging studies, and a physical exam), every 1-3 months for the 1st year after treatment, every 6 months for the 2nd year, and then as determined by your doctor</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CAR T-cell is a personalized immunotherapy made from your white blood cells. </li> <li class="seamTextUnorderedListItem">After your blood cells are removed, they are modified with chimeric antigen receptors (CARs) so they can attack specific proteins. </li> <li class="seamTextUnorderedListItem">The CAR T-cells are then infused back into you while you are hospitalized. </li> <li class="seamTextUnorderedListItem">The CAR T-cell therapy used in this study is designed to get the immune system to see and kill cancer cells that are CD70+. </li> <li class="seamTextUnorderedListItem">Along with the CAR-T immunotherapy, you will receive the chemotherapy drugs fludarabine and cyclophosphamide. These drugs are given to deplete the lymph cells. </li> <li class="seamTextUnorderedListItem">You will also receive aldesleukin, a drug that stimulates the growth and development of T cells.</li> <li class="seamTextUnorderedListItem">Targets or mutations: CD70</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02830724' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.drsusanloveresearch.org/videos/chimeric-antigen-receptor-t-cell-car-t-therapy' target='_blank'>Dr Susan Love Research Foundation: CAR-T Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/25368676' target='_blank'>Journal Article Abstract: CD70, A Potential Target in Breast Cancer?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/search?contains=false&q=Aldesleukin' target='_blank'>NCI Drug Dictionary: Aldesleukin</a> </li></ul>
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451

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03190967

Kadcyla and Temodar for Recurrent HER2+ Brain Metastases from Breast Cancer

Phase I/II Study of T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using a targeted therapy along with chemotherapy to treat HER2-positive breast cancer that has spread to the brain.
Who is this for?
Women with HER2 positive breast cancer with brain metastases that were recently treated with stereotactic radiation and/or surgery.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Temozolomide (Temodar®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">2 lumbar punctures (spinal taps)</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T-DM1 (Kadcyla®), by IV, every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">2 lumbar punctures (spinal taps)</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The targeted therapy used in this study is T-DM1 (Kadcyla®). It is used to treat HER2-positive metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">It combines the chemotherapy drug DM1 with the HER2-targeted drug trastuzumab (Herceptin®). </li> <li class="seamTextUnorderedListItem">The chemotherapy drug used in this study is temozolomide (Temodar®). It is used to treat brain cancer. </li> <li class="seamTextUnorderedListItem">Participants will have at least two lumbar punctures (spinal taps) under local anesthesia.</li> <li class="seamTextUnorderedListItem">During lumbar puncture, imaging will guide the insertion of a needle into the spinal canal in the lower back to collect cerebrospinal fluid. </li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03190967' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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452

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD

VISITS: 1 visit per month, ongoing

PHASE: II

NCT ID: NCT03394027

ONC201 for Estrogen Receptor Positive or Triple Negative Metastatic Breast Cancer

A Phase 2 Study of ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma Scientific Title

Purpose
To examine the safety and effectiveness of using an experimental drug called ONC201 to slow cancer growth.
Who is this for?
People with estrogen receptor positive or triple negative (ER-, PR- and HER2-) metastatic breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONC201, by mouth, once a week, ongoing</li> <li class="seamTextUnorderedListItem">Two biopsies, before starting treatment and 5 weeks after</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is also enrolling women with advanced endometrial cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03394027' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://oncoceutics.com/onc201-trial-begins-endometrial-breast-cancer/' target='_blank'>oncoceutics: ONC201 Trial Begins for Endometrial and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/akt-erk-inhibitor-onc201' target='_blank'>cancer.gov: Akt/ERK inhibitor ONC201</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.eurekalert.org/pub_releases/2018-05/rp-okb050818.php' target='_blank'>EurekAlert: ONC201 kills breast cancer cells in vitro by targeting mitochondria</a> </li></ul>
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453

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD

VISITS: Hospital stay for up to 9 days; screening test every few months for 2 years

PHASE: II

NCT ID: NCT03412877

Using Personalized T-Cells Along with Chemotherapy to Treat Metastatic Breast Cancer

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in People With Metastatic Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of an immunotherapy that uses personalized T cells.
Who is this for?
People with metastatic (stage IV) breast cancer for which standard treatments have not worked.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be in the hospital and receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Before hospital stay:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leukapheresis (blood draw for the collection of cells), 2-4 months before receiving treatment</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Hospital stay for receiving treatment (2-3 weeks):</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®), by IV, once a day, for 2 days </li> <li class="seamTextUnorderedListItem">Fludarabine (Fludara), by IV, once a day, for 5 days</li> <li class="seamTextUnorderedListItem">Followed by Aldesleukin, by IV, once every 8 hours, for up to 4 days </li> <li class="seamTextUnorderedListItem">TCR-Transduced T-Cells, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">After hospital stay:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Antibiotic and antiviral, for at least 6 months</li> <li class="seamTextUnorderedListItem">Screening tests, every few months for the first year, every 6 months for the second year, then as determined</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">To create the personalized T cells, cancer cells will be taken from your tumor and white blood cells will be removed from your blood. </li> <li class="seamTextUnorderedListItem">The cancer cells will be analyzed to learn about the genetic mutations they contain. </li> <li class="seamTextUnorderedListItem">In a lab, your white blood cells will be modified in ways that will help them go after your tumor cells. </li> <li class="seamTextUnorderedListItem">They will then be infused into your body. This will take place in the hospital where the research study is taking place. </li> <li class="seamTextUnorderedListItem">When you receive the infused T cells, you will also be given Aldesleukin, an immune function enhancing drug. </li> <li class="seamTextUnorderedListItem">Your treatment will also include two chemotherapy drugs: cyclophosphamide (Cytoxan), which is used to treat breast cancer, and fludarabine (Fludara), which is approved to treat chronic lymphocytic leukemia (CLL). </li> <li class="seamTextUnorderedListItem">This trial also is enrolling patients with other types of metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03412877' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/press-releases/2014/ACTepithelial' target='_blank'>National Cancer Institute Press Release: Immunotherapy</a> </li></ul>
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454

NEAREST SITE: 2432 miles
National Cancer Institute
Bethesda,MD

VISITS: At least 1 visit every 2 weeks

PHASE: I

NCT ID: NCT03476681

NEO-201 in People With Advanced Breast Cancer

Phase 1 With Expansion Cohorts in a Study of NEO-201 in Adults With Chemo-Resistant Solid Tumors (QUILT-3.017) Scientific Title

Purpose
To study the safety, best dose, and effects (good and bad) of the experimental therapy NEO-20.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NEO-201, by IV, every 2 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NEO-20 is a monoclonal antibody that binds to proteins called CEACAMs (carcinoembryonic antigen-related cell adhesion molecules). These proteins help tumors grow and keep the immune system from attacking the tumor. </li> <li class="seamTextUnorderedListItem">By blocking CECAMs, NEO-20 may slow tumor growth and/or get the immune system to kill cancer cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling people with other types of advanced and metastatic solid tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03476681' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/795513' target='_blank'>NCI Drug Dictionary: Monoclonal Antibody NEO-201</a> </li><li class='seamTextUnorderedListItem'><a href='https://precision-biologics.com/pipeline/' target='_blank'>Drug Company Information Page: NEO-201</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/monoclonal-antibody/art-20047808' target='_blank'>Mayo Clinic: Monoclonal Antibodies Drugs for Cancer, How They Work.</a> </li><li class='seamTextUnorderedListItem'><a href='https://ccr.cancer.gov/news/article/clinical-trial-tests-safety-and-dosing-of-neo-201-antibody-in-patients-with-advanced-cancer' target='_blank'>NCI Center for Cancer Research: Trial Information</a> </li></ul>
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455

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD

VISITS: Hospital stay for 4-5 weeks

PHASE: II

NCT ID: NCT04102436

CAR T-Cell Immunotherapy for Metastatic Breast Cancer

A Phase II Study Using the Administration of Autologous T-Cells Engineered Using the Sleeping Beauty Transposon/Transposase System to Express T-Cell Receptors Reactive Against Mutated Neoantigens in Patients With Metastatic Cancer Scientific Title

Purpose
To study if an immunotherapy, made from your own white blood cells that are then modified with T-cell receptors, can cause breast cancer tumors to shrink.
Who is this for?
People with metastatic breast cancer that did not respond to the first treatment received.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be in the hospital and receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Before hospital stay:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw for the collection of cells (leukapheresis)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Hospital stay for receiving treatment (4-5 weeks):</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Modified white blood cells (CAR T-cell immunotherapy), by IV</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®) and Fludarabine (Fludara®), by IV</li> <li class="seamTextUnorderedListItem">Aldesleukin, by IV, once every 8 hours, for up to 10 doses</li> <li class="seamTextUnorderedListItem">Antibiotics</li> <li class="seamTextUnorderedListItem">Filgrastim, by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">After hospital stay:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visits approximately 6 and 12 weeks after treatment, then every 3-6 months for 3 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T-cells can be modified in a lab to recognize certain changes in the tumor. </li> <li class="seamTextUnorderedListItem">To create the personalized T cells, your white blood cells will be collected and modified in ways that will help them go after your tumor cells. </li> <li class="seamTextUnorderedListItem">These supercharged T cells will then be put into your body. This will be done in the hospital. </li> <li class="seamTextUnorderedListItem">This type of therapy is called CAR T-cell therapy. </li> <li class="seamTextUnorderedListItem">Before you receive the enhanced T cells, you will be treated with the chemotherapy drugs cyclophosphamide (Cytoxan®) and fludarabine (Fludara®). This is to prepare your body to receive the enhanced T cells. </li> <li class="seamTextUnorderedListItem">You will also receive aldesleukin, a drug that enhances immune function and filgrastim, to reduce your risk of developing an infection. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04102436' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/research/car-t-cells' target='_blank'>NCI Research Article: CAR T Cells, Engineering Patients’ Immune Cells to Treat Their Cancers</a> </li></ul>
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456

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD

VISITS: 2 short hospital stays, then 1 visit a week, ongoing

PHASE: I

NCT ID: NCT04222413

Metarrestin (ML-246) for Metastatic Breast Cancer

First-in-Human Phase I Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors. Scientific Title

Purpose
To find the best dose and study the safety and anti-cancer activity of the experimental targeted therapy metarrestin (ML-246).
Who is this for?
People with metastatic (stage IV) breast cancer who have no standard therapy options available.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metarrestin, by mouth, 1 to 5 days a week, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Two short hospital stays during the first month are required.</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Drug diary</li> <li class="seamTextUnorderedListItem">Questionnaires</li> <li class="seamTextUnorderedListItem">CT scan or MRI</li> <li class="seamTextUnorderedListItem">Cognitive tests</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metarrestin (ML-246) is an experimental targeted therapy.</li> <li class="seamTextUnorderedListItem">Metarrestin breaks down a part of the cancer cell called the perinucleolar compartment (PNC). </li> <li class="seamTextUnorderedListItem">Breaking down PNCs may reduce cancer progression. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04222413' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/800687' target='_blank'>NCI Drug Dictionary: Metarrestin (ML-246)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.kucancercenter.org/news-room/news/2018/06/metastasis-suppressing-compound' target='_blank'>The University of Kansas Cancer Center: Researchers Identify Metastasis-Suppressing Compound</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nih.gov/news-events/news-releases/nih-northwestern-scientists-develop-potential-new-approach-stop-cancer-metastasis' target='_blank'>NIH News Release: NIH, Northwestern Scientists Develop Potential New Approach to Stop Cancer Metastasis</a> </li></ul>
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457

NEAREST SITE: 2433 miles
Sibley Memorial Hospital
Washington,DC

VISITS: 10 visits over 6 weeks

PHASE: NA

NCT ID: NCT03143894

Non-Invasive Brain Stimulation to Reduce Fatigue & Improve Thinking Skills

Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation Scientific Title

Purpose
To learn whether non-invasive brain stimulation reduces fatigue and improves thinking skills in breast cancer survivors.
Who is this for?
Women who have completed breast cancer treatment within the past 6 months to 5 years and have persistent fatigue.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">30-minute brain stimulation, once daily for 5 consecutive days; twice over 6 weeks</li> <li class="seamTextUnorderedListItem">Follow-up questionnaire by phone, 1 week later</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">30-minute sham stimulation, once daily for 5 consecutive days; twice over 6 weeks</li> <li class="seamTextUnorderedListItem">Follow-up questionnaire by phone, 1 week later</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The brain stimulation technique is called transcranial direct current stimulation (tDCS). </li> <li class="seamTextUnorderedListItem">Previous studies have found it can improve fatigue and thinking skills.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03143894' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Transcranial_direct-current_stimulation' target='_blank'>Wikipedia: Transcranial direct-current stimulation (tDCS)</a> </li></ul>
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458

NEAREST SITE: 2434 miles
Lombardi Comprehensive Cancer Center
Washington,DC

VISITS: Coincides with chemotherapy treatment

PHASE: II

NCT ID: NCT02910219

Preventing Diarrhea in Patients Being Treated for HER2+ Breast Cancer

Diarrhea Prevention and Prophylaxis With Crofelemer in HER2 Positive Breast Cancer Patients Receiving Trastuzumab, Pertuzumab, and Docetaxel or Paclitaxel With or Without Carboplatin: HALT-D Scientific Title

Purpose
To see if an anti-diarrhea medicine can help prevent chemotherapy-induced diarrhea in HER2+ breast cancer patients.
Who is this for?
People with any stage of HER2 positive breast cancer who are scheduled to receive either THP or TCHP therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups during the first 2 cycles of chemotherapy with THP or TCHP: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Crofelemer (Mytesi®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No intervention</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The anti-diarrhea medicine being used in this study is Crofelemer (Mytesi®). It is used to prevent diarrhea in HIV/AIDS patients. </li> <li class="seamTextUnorderedListItem">The THP chemotherapy regimen contains docetaxel (Taxotere®), trastuzumab (Herceptin®), and pertuzumab (Perjeta®). </li> <li class="seamTextUnorderedListItem">The TCHP regimen contains docetaxel (Taxotere®), carboplatin (Paraplatin®), trastuzumab (Herceptin®), and pertuzumab (Perjeta®).</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02910219' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.fulyzaq.com/' target='_blank'>Crofelemer (Mytesi®)</a> </li></ul>
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459

NEAREST SITE: 2434 miles
Georgetown University
Washington,DC

VISITS: 1 visit

PHASE: NA

NCT ID: NCT03091647

Acupressure for Chinese Immigrant Breast Cancer Survivors in Los Angeles

Acupressure Intervention to Improve Fatigue and Physical Functioning of Chinese Immigrant Breast Cancer Survivors Scientific Title

Purpose
To see whether using a Chinese-language video to teach patients how to self-administer acupressure helps improve cancer-related fatigue and quality of life better than the current standard of care.
Who is this for?
First-generation immigrants who speaks Chinese (Mandarin or Cantonese) and live in or near Los Angeles, California. You must have been treated for DCIS or Stage I, II, or III breast cancer within the last 1 to 5 years and have moderate to severe levels of fatigue.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Acupressure</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Learn acupressure practice from an instructional video in Chinese </li> <li class="seamTextUnorderedListItem">Self-administer acupressure and record practice in a log, daily, for 2 months</li> <li class="seamTextUnorderedListItem">2 phone interviews, at baseline and at follow-up </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care support </li> <li class="seamTextUnorderedListItem">Record fatigue and functioning levels in a log, daily, for 2 months </li> <li class="seamTextUnorderedListItem">2 phone interviews, at baseline and at follow-up</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is investigating whether using a Chinese-language video to teach patients how to self-administer acupressure helps improve cancer-related fatigue and quality of life better than the current standard of care.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03091647' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/Acupressure.html' target='_blank'>Susan G. Komen: Acupressure</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/self-acupressure-eases-anxiety-pain-depression' target='_blank'>Breastcancer.org: Self-administered Acupressure</a> </li></ul>
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460

NEAREST SITE: 2434 miles
MedStar Georgetown University Hospital
Washington,DC

VISITS: Number of visits unavailable, over 12 days

PHASE: II

NCT ID: NCT03535506

Palbociclib Before Surgery For DCIS

Preoperative Palbociclib in Patients With DCIS of the Breast That Are Candidates for Surgery Scientific Title

Purpose
To look at the safety of treating people with DCIS with palbociclib (Ibrance®) before surgery.
Who is this for?
People who have been diagnosed with DCIS and are scheduled to have surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, for 12 days </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No treatment before surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ibrance is a type of targeted therapy called a CDK 4/6 inhibitor. </li> <li class="seamTextUnorderedListItem">It is approved to treat HR+, HER2- metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03535506' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/ibrance' target='_blank'>Breastcancer.org: Ibrance®</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/RecommendedTreatmentsforDuctalCarcinomaInSitu.html' target='_blank'>Susan G. Komen: Treatment for DCIS</a> </li></ul>
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461

NEAREST SITE: 2434 miles
Lombardi Comprehensive Cancer Center
Washington,DC

VISITS: 3 visits per month, ongoing

PHASE: I

NCT ID: NCT03854903

Ibrance, Bosutinib & Fulvestrant for Advanced HR+ HER2- Breast Cancer

A Phase I Trial of Palbociclib and Bosutinib With Fulvestrant in Patients With Metastatic Hormone Receptor Positive and HER2 Negative (HR+ HER2-) Breast Cancer Refractory to an Aromatase Inhibitor and a CDK4/6 Inhibitor Scientific Title

Purpose
To evaluate the safety, best dose and effects (good and bad) of bosutinib (Bosulif®) when it is used along with palbociclib (Ibrance®) and fulvestrant (Faslodex®).
Who is this for?
Women with estrogen receptor positive, HER2 negative advanced (some stage III) or metastatic (stage IV) breast cancer, who have had no more than 3 chemotherapy regimens, and have been treated with at least one aromatase inhibitor and one CDK 4/6 inhibitor.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, 3 weeks on, 1 week off</li> <li class="seamTextUnorderedListItem">Bosutinib (Bosulif®), by mouth, 5 days on, 2 days off</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 3 times a month, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bosulif is a targeted therapy approved to treat certain types of leukemia. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Ibrance is a targeted therapy approved to treat metastatic breast cancer in combination with Faslodex or letrozole (Femara®), which are both hormone therapies.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03854903' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/bosutinib' target='_blank'>NCI Drug Dictionary: Bosutinib</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2018/08/01/mbc-news/' target='_blank'>Metastatic Trial Talk.org: Update on CDK Inhibitors</a> </li></ul>
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462

NEAREST SITE: 2435 miles
Georgetown University Hospital
Washington,DC

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02457117

Study of Women 50 and Over Who Get CyberKnife Radiation for DCIS or Stage I Breast Cancer

A Multi-Institutional Registry for CyberKnife Stereotactic Accelerated Partial Breast Irradiation (CK-SAPBI) Scientific Title

Purpose
To establish a registry and to collect information about the effectiveness and cosmetic outcomes seen with CK-SAPBI.
Who is this for?
Women 50 and older who have received cyberknife radiotherapy (CK-SAPBI) for DCIS or stage I breast cancer.    Full eligibility criteria
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  • <p class="seamTextPara"> All participants will be monitored over 5 years following CK-SAPBI therapy.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">There are different types of radiation therapy women can receive as part of their breast cancer treatment. </li> <li class="seamTextUnorderedListItem">CK-SAPBI (CyberKnife® Stereotactic Accelerated Partial Breast Irradiation) is a type of radiation therapy that delivers a targeted, high dose of radiation over a short period of time with limited damage to surrounding healthy tissue. </li> <li class="seamTextUnorderedListItem">Results from early studies suggest CK-SAPBI technique is as safe and effective as traditional whole breast radiation</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02457117' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cyberknife.com/cyberknife-overview/how-unique.aspx' target='_blank'>CyberKnife</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.mdanderson.org/patient-and-cancer-information/cancer-information/cancer-topics/cancer-treatment/radiation/partial-breast-irradiation/index.html' target='_blank'>MD Anderson: Accelerated Partial Breast Irradiation</a> </li></ul>
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463

NEAREST SITE: 2437 miles
Penn State Hershey Medical Center
Hershey,PA

VISITS: Coincides with chemotherapy treatment

PHASE: NA

NCT ID: NCT03280836

Exercise Program for Women Receiving Chemotherapy Before Surgery

Women In Steady Exercise Research - Neoadjuvant Exercise Trial Scientific Title

Purpose
To study the effectiveness of an at-home aerobic exercise training program.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who are scheduled to receive chemotherapy before their breast cancer surgery    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Participate in a personalized exercise program, 75 or more minutes per week</li> <li class="seamTextUnorderedListItem">Wear a heart rate monitor during exercise</li> <li class="seamTextUnorderedListItem">Keep an exercise log </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No exercise intervention</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03280836' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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464

NEAREST SITE: 2438 miles
Walter Reed Army Medical Center
Washington,DC

VISITS: 1 visit

PHASE: NA

NCT ID: NCT01322750

A Circulating Tumor Cell Test To Screen For Breast Cancer At Walter Reed National Military Medical Center

Circulating Tumor Cells (CTCs): A Potential Screening Test for Clinically Undetectable Breast Carcinoma Scientific Title

Purpose
To study if a blood test for circulating tumor cells (CTCs) can reliably find breast cancer before your cancer has become clinically detectable (seen on a mammogram, ultrasound, or other imaging).
Who is this for?
People without breast cancer and people with DCIS, stage I, stage II, or stage III breast cancer who are having a diagnostic or therapeutic procedure (biopsy, lumpectomy, mastectomy) done at Walter Reed National Military Medical Center.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will have your blood drawn</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Scientists are researching new techniques to screen for breast cancer.</li> <li class="seamTextUnorderedListItem">Breast cancer cells can leave the tumor and move through the blood stream before the tumor is clinically detectable.</li> <li class="seamTextUnorderedListItem">Circulating tumor cell tests look for these traveling cancer cells and may provide a simple, reliable, and cost-effective form of breast cancer screening.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01322750' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cbcp-research.org' target='_blank'>Walter Reed National Military Medical Center: Clinical Breast Care Project</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/testing/types/blood_marker.jsp' target='_blank'>Breastcancer.org: Blood Marker Tests</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/types/breast/patient/breast-screening-pdq' target='_blank'>NCI: Breast Cancer Screening</a> </li></ul>
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465

NEAREST SITE: 2452 miles
Baltimore VA Medical Center
Baltimore,MD

VISITS: Visits 3 times a week for 3 months

PHASE: NA

NCT ID: NCT02991677

Effect of Exercise on Chemotherapy-Related Pain and Numbness in Hands and Feet

Exercise Effect on Chemotherapy-Induced Neuropathic Pain, Peripheral Nerve Fibers Scientific Title

Purpose
To investigate whether aerobic exercise or resistance training exercise can help decrease chemotherapy-related peripheral neuropathy.
Who is this for?
People with stage I, stage II, stage III and stage IV breast cancer who were treated with oxaliplatin (Eloxitin®), docetaxel (Taxotere®) or paclitaxel (Taxol®). You must have completed this chemotherapy between 6 months and 1 year prior to study enrollment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aerobic exercise, 3 times a week for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Resistive training exercise, 3 times a week for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No exercise intervention</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Certain types of chemotherapy drugs can cause patients to develop peripheral neuropathy-pain and numbness in the hands and feet. </li> <li class="seamTextUnorderedListItem">Aerobic exercise or resistance training exercise may help decrease chemotherapy-related peripheral neuropathy.</li> <li class="seamTextUnorderedListItem">The aerobic exercise program will involve walking or running on a treadmill. </li> <li class="seamTextUnorderedListItem">The resistance training will use muscles in your upper-body and lower-body. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02991677' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/side_effects/neuropathy' target='_blank'>Breastcancer.org: Neuropathy</a> </li></ul>
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466

NEAREST SITE: 2453 miles
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore,MD

VISITS: No additional visits required

PHASE: NA

NCT ID: NCT01937039

Johns Hopkins Breast Cancer Program Tissue Bank

Johns Hopkins Breast Cancer Program Longitudinal Repository Scientific Title

Purpose
To store blood, breast tissue and urine samples donated periodically for up to 20 years by women with breast cancer or benign breast disease as well as healthy women and provide them to breast cancer researchers in order for them to study what causes breast cancer and how to treat it.
Who is this for?
People being seen at Johns Hopkins for breast cancer treatment, or for any screening or diagnostic breast procedures    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will provide blood, urine, and tissue samples periodically over time (up to 20 years).</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Breast Cancer Program at Johns Hopkins, in Baltimore, Maryland, has started a Longitudinal Repository-also known as a tissue bank.</li> <li class="seamTextUnorderedListItem">The Repository will store blood, breast tissue and urine samples donated periodically for up to 20 years by women with breast cancer or benign breast disease as well as healthy women. </li> <li class="seamTextUnorderedListItem">The Repository will provide blood, tissue, and urine samples donated by these women to breast cancer researchers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01937039' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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467

NEAREST SITE: 2453 miles
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore,MD

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT02965755

Tumor Molecular Profiling by Liquid Biopsy for Choosing Treatments for Metastatic Breast Cancer

Individualized Molecular Analyses Guide Efforts in Breast Cancer - Personalized Molecular Profiling in Cancer Treatment at Johns Hopkins Scientific Title

Purpose
To study if a liquid biopsy (blood test) can give the same genetic information as a tumor biopsy (tumor tissue test) and if the genetic information can help doctors choose your next treatment.
Who is this for?
People being treated for metastatic (stage IV) breast cancer who have already received chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Genetic profiling of your cancer using a liquid biopsy (blood test)</li> <li class="seamTextUnorderedListItem">Genetic profiling of your cancer using a tumor sample already in your medical records</li> <li class="seamTextUnorderedListItem">Possible treatment recommendations based on the results of the genetic profiling</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The information obtained from the liquid biopsy may help guide recommendations for your next treatment.</li> <li class="seamTextUnorderedListItem">Targets or mutations: varies based on your test results</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02965755' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/KomenPerspectives/Tumor-profiling-–-personalizing-treatment-for-breast-cancer.html' target='_blank'>Susan G. Komen: Tumor Profiling-Personalizing Treatment for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2017/liquid-biopsy-detects-treats-cancer' target='_blank'>NCI Cancer Currents Blog: Liquid Biopsy</a> </li></ul>
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468

NEAREST SITE: 2453 miles
Johns Hopkins University
Baltimore,MD

VISITS: 2 visits in the first month; visits every 3-4 months while on treatment

PHASE: II

NCT ID: NCT03439735

Predicting Response to Treatment with an AI and Palbociclib for HR+ Advanced Breast Cancer

Prospective Evaluation of Determinants of Resistance to First-line Therapy With an Aromatase Inhibitor and the Cyclin-dependent Kinases 4 and 6 Inhibitor Palbociclib in Hormone Receptor Positive Metastatic Breast Cancer Scientific Title

Purpose
To see if certain blood and tumor tests can help researchers predict which patients' tumors will respond to an aromatase inhibitor and Ibrance®.
Who is this for?
People with newly diagnosed estrogen receptor positive (ER+) and/or progesterone receptor positive (PR+) advanced breast cancer who will be treated with an aromatase inhibitor and palbociclib (Ibrance®).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws: at the start of treatment, 1 month later, and every 3-4 months while on treatment</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The researchers will analyze each patient's tumor tissue and blood samples during treatment. </li> <li class="seamTextUnorderedListItem">They will be looking specifically at a mutation, called ESR1, that can develop in cancer cells. </li> <li class="seamTextUnorderedListItem">Previous studies have suggested that cancer cells with this mutation may be less likely to respond to an aromatase inhibitor. </li> <li class="seamTextUnorderedListItem">The researchers will use what they learn to help doctors personalize treatment options for metastatic breast cancer patients.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03439735' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://jhoponline.com/breast-cancer/17182-esr1-mutations-occur-often-in-estrogen-receptor-positive-breast-cancer' target='_blank'>Journal article: ESR1 Mutations Occur Often in Estrogen Receptor–Positive Breast Cancer</a> </li></ul>
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469

NEAREST SITE: 2453 miles
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore,MD

VISITS: 1 visit every 2 weeks, for 3 months

PHASE: II

NCT ID: NCT03573648

Tamoxifen, Palbociclib, Avelumab Before Surgery in ER Positive Breast Cancer

A Pilot Study of IMMUNe mOdulation in Early Stage Estrogen Receptor Positive Breast Cancer Treated With neoADjuvant Avelumab, Palbociclib, and Tamoxifen: The ImmunoADAPT Study Scientific Title

Purpose
To see whether giving tamoxifen and avelumab before surgery shrinks tumors more than the combination of tamoxifen, avelumab and palbociclib.
Who is this for?
People with stage II or stage III ER-positive breast cancer that will be treated with surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, once every 2 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®), by mouth, daily, for 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®), by IV, once every 2 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®), by mouth, daily, for 4 months</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on and 1 week off), for 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®) is a hormonal therapy used to treat ER-positive breast cancer.</li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®) is a type of immunotherapy drug called a PD-L1 inhibitor. It is approved to treat non-small-cell lung cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a CDK inhibitor. It is approved to treat ER-positive, HER2-negative metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Giving therapies before surgery, called neoadjuvant treatment, allows researchers to measure how tumors respond to different therapies.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03573648' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.practiceupdate.com/content/avelumab-is-clinically-active-and-safe-in-advancedmetastatic-breast-cancer/60403' target='_blank'>PracticeUpdate: Avelumab Is Clinically Active and Safe in Advanced/Metastatic Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/sabcs-2015/avelumab-effective-in-pd-l1-positive-metastatic-breast-cancer' target='_blank'>OncLive: Avelumab Effective in PD-L1-Positive Metastatic Breast Cancer</a> </li></ul>
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470

NEAREST SITE: 2494 miles
Lehigh Valley Health Network
Allentown,PA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT01775072

Analyzing Genetic Mutations Before and After Treatment with Targeted Therapies

A Basket Study: Tumor Genomic Profiling in Patients Evaluated for Targeted Cancer Therapy Scientific Title

Purpose
To compare genetic mutations seen in a tumor sample before and after treatment with a targeted therapy. The study will investigate how tumor mutations can be used to predict a cancer's response to treatment and how they change in response to targeted therapies.
Who is this for?
People who are receiving ongoing care at Memorial Sloan Kettering Cancer Center.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will be asked to provide: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A tube of blood</li> <li class="seamTextUnorderedListItem">Cheek swab (also known as a buccal), or a saliva sample that contains normal genes for comparison</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Leftover tumor tissue from a previous surgery or biopsy will be used for genomic testing.</i></p>
  • <p class="seamTextPara"> Most genetic mutations found in cancer cells are not passed down from parents (inherited), but occur when the cells make mistakes when they divide. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Most cancers have many mutations. </li> <li class="seamTextUnorderedListItem">Some of these mutations help drive the tumor's growth, while others are just bystanders.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01775072' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT01775072?term=NCT01775072&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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471

NEAREST SITE: 2494 miles
Lehigh Valley Health Network
Allentown,PA

VISITS: Monthly visits, ongoing

PHASE: I-II

NCT ID: NCT03377387

Neratinib and Xeloda for Metastatic HER2+ Breast Cancer

Phase Ib/II Study of Capecitabine 7/7 Schedule With Neratinib in Patients With Metastatic HER2-Positive Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of using a targeted therapy in combination with different doses of a standard chemotherapy.
Who is this for?
Women with HER2 positive metastatic (stage IV) breast cancer who have received prior Herceptin. You may have had up to 4 prior regimens of chemotherapy    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capacitabine (Xeloda®), by mouth, daily (1 week on, 1 week off) </li> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth daily</li></ul>
  • <p class="seamTextPara"> The targeted therapy that is being used in this study is neratinib (Nerlynx®). It is approved to treat certain patients with HER2+ early-stage breast cancer. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Capacitabine (Xeloda®) is approved by the FDA for treating advanced breast cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03377387' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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472

NEAREST SITE: 2494 miles
Lehigh Valley Health Network
Allentown,PA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03808337

Stereotactic Body Radiotherapy (SBRT) Combined with Standard of Care Treatment for Metastatic Breast Cancer

A Phase II Randomized Study Assessing the Efficacy of Stereotactic Body Radiotherapy (SBRT) in Patients With Oligometastatic Breast or Lung Cancer Scientific Title

Purpose
To compare the effects (good and bad) of using stereotactic body radiotherapy (SBRT) along with a standard of care treatment to a standard of care treatment alone.
Who is this for?
People with metastatic (stage IV) triple negative breast cancer (ER-, PR- and HER2-).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic Body Radiotherapy (SBRT)</li> <li class="seamTextUnorderedListItem">Standard of care determined by your physician</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care determined by your physician</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">SBRT can be used to deliver precise, intense doses of radiation to specific places where the cancer has spread. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03808337' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/radiotherapy/external/types/stereotactic-body-radiotherapy-sbrt' target='_blank'>CancerResearchUK: Stereotactic Radiotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.uclahealth.org/radonc/faqs-sbrt' target='_blank'>UCLA Health: SBRT FAQs</a> </li></ul>
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473

NEAREST SITE: 2517 miles
Abramson Cancer Center of the University of Pennsylvania
Philadelphia,PA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03032406

Plaquenil and Afinitor to Prevent Breast Cancer Recurrence

CLEVER Pilot Trial: A Phase II Pilot Trial of HydroxyChLoroquine, EVErolimus or the Combination for Prevention of Recurrent Breast Cancer Scientific Title

Purpose
To see whether Plaquenil® alone, Afinitor® alone, or a combination of the two drugs reduces the risk of recurrence.
Who is this for?
People who have been treated for stage II HER2 negative breast cancer within the past 5 years. Disseminated tumor cells (DTCs) must be found in your bone marrow after you completed treatment. The researchers will test you for DTCs.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hydroxychloroquine (Plaquenil®), by mouth, twice daily, up to 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth, daily, up to 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hydroxychloroquine (Plaquenil®), by mouth, daily, up to 1 year</li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth, daily, up to 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Observation for 3 months, followed by</li> <li class="seamTextUnorderedListItem">Hydroxychloroquine (Plaquenil®), by mouth, daily, up to 1 year</li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth, daily, up to 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">At least 2 bone marrow biopsies</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hydroxychloroquine (Plaquenil®) is a drug commonly used to prevent and treat malaria.</li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®) is a type of targeted drug called an mTOR inhibitor. It is used to treat advanced hormone receptor positive (ER+ and/or PR+), HER2 negative breast cancer.</li> <li class="seamTextUnorderedListItem">This study is investigating whether Plaquenil® alone, Afinitor alone, or a combination of the two drugs reduces the risk of recurrence in HER2-negative breast cancer survivors who have DTCs.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03032406' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pennmedicine.org/cancer/cancer-research/translating-research-to-practice/breast-cancer-tce/clever-study' target='_blank'>Penn Medicine Abramson Cancer Center: CLEVER Study</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.futuremedicine.com/doi/pdf/10.2217/bmm.09.17' target='_blank'>Disseminated tumor cells as biomarkers for breast cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/hydroxychloroquine' target='_blank'>NCI Drug Dictionary: Hydroxychloroquine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.us.afinitor.com' target='_blank'>Novartis Pharmaceuticals Information Page: Everolimus</a> </li></ul>
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474

NEAREST SITE: 2519 miles
Thomas Jefferson University
Philadelphia,PA

VISITS: 1 visit

PHASE: II

NCT ID: NCT02874430

Metformin and Antibiotics Before Surgery for DCIS and Early Stage Breast Cancer

A Phase II Study of Metformin in Combination With Doxycycline in Patients With Localized Breast and Uterine Cancer Scientific Title

Purpose
To see if combining metformin with doxycycline will be an effective cancer treatment.
Who is this for?
Women recently diagnosed with DCIS or stage I, stage II, or stage III breast cancer who are scheduled to have their tumor removed by surgery at Thomas Jefferson University Hospital in Pennsylvania.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following up to 1 week before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metformin hydrochloride, by mouth, twice daily, up to 5 weeks</li> <li class="seamTextUnorderedListItem">Doxycycline, by mouth, twice daily, up to 5 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metformin hydrochloride is a drug used to treat diabetes. It may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. </li> <li class="seamTextUnorderedListItem">Doxycycline is a commonly used antibiotic drug. It may stop the growth of bacteria by keeping them from making proteins and minimize the toxic side effects of anti-cancer therapy. </li> <li class="seamTextUnorderedListItem">It is not yet known whether giving metformin hydrochloride together with doxycycline may be a better way in treating patients.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02874430' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/oncolog/november-december-2014/beyond-diabetes-metformin-may-have-broad-utility-in-cancer.html' target='_blank'>MD Anderson: Metformin May Have Broad Utility in Cancer</a> </li></ul>
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475

NEAREST SITE: 2519 miles
Sidney Kimmel Cancer Center at Thomas Jefferson University
Philadelphia,PA

VISITS: 2 visits a week for 3 weeks

PHASE: I

NCT ID: NCT03955640

Hyperthermia and Olaparib for Breast Cancer That Has Come Back in the Chest Wall

A Pilot Trial of Hyperthermia in Combination With Olaparib in Breast Cancer Patients With Chest Wall Recurrences Scientific Title

Purpose
To determine the best dose and effects (good and bad) of olaparib (Lynparza®) when it is used along with hyperthermia.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) breast cancer who do not have an inherited BRCA mutation and whose cancer has come back in the chest wall.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice a day, for 1 month</li> <li class="seamTextUnorderedListItem">Hyperthermia treatment, twice a week, for 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lynparza is a type of targeted therapy called a PARP inhibitor. </li> <li class="seamTextUnorderedListItem">It is approved to treat patients with an inherited BRCA mutation who have HER2-negative metastatic breast cancer that was previously treated with chemotherapy. </li> <li class="seamTextUnorderedListItem">Hyperthermia is a treatment that uses heat to kill or damage cancer cells. It is being studied in clinical trials.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03955640' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-approves-olaparib-for-brca-breast-cancer' target='_blank'>OncLive: FDA Approves Olaparib for BRCA+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/hyperthermia.html' target='_blank'>Cancer.org: Hyperthermia to Treat Cancer</a> </li></ul>
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476

NEAREST SITE: 2519 miles
Glenmark Investigational Site 3
Philadelphia,PA

VISITS: Weekly visits

PHASE: I-II

NCT ID: NCT03983395

GBR 1302 in HER2-positive Metastatic Breast Cancer

A Phase 1/2, Open-Label, Dose-Escalation Study of GBR 1302 in Subjects With HER2-Positive Metastatic Breast Cancer Scientific Title

Purpose
To determine the safety and best dose of an investigational immunotherapy called GBR 1302.
Who is this for?
Women with HER2 positive metastatic (stage IV) breast cancer who have been treated with all standard options.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GBR 1302, by IV, once a week</li> <li class="seamTextUnorderedListItem">2 biopsies (1 before starting treatment and 1 while on treatment)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This drug stimulates immune cells to go after HER2+ cancer cells by targeting CD3 on immune cells and HER2 on cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03983395' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://oncologypro.esmo.org/Meeting-Resources/ESMO-2018-Congress/Preliminary-Results-from-a-Phase-1-Study-of-GBR-1302-A-Bispecific-Antibody-T-Cell-Engager-in-HER2-Positive-Cancers' target='_blank'>OncologyPro.ESMO.org: Preliminary Results from a Phase 1 Study of GBR 1302</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-her2-anti-cd3-bispecific-monoclonal-antibody-gbr-1302' target='_blank'>NCI Drug Dictionary: GBR 1302</a> </li></ul>
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477

NEAREST SITE: 2521 miles
Fox Chase Cancer Center
Philadelphia,PA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03125928

Tecentriq plus Taxol, Herceptin and Perjeta for HER2+ Advanced Breast Cancer

Single Arm, Phase IIA Clinical Trial Assessing The Safety And Efficacy of Atezolizumab in Combination With Paclitaxel, Trastuzumab, and Pertuzumab in Patients With Metastatic HER-2 Positive Breast Cancer Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of adding an immunotherapy to the standard treatment for HER2-positive advanced breast cancer.
Who is this for?
Women with HER2 positive advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®)</li> <li class="seamTextUnorderedListItem">Standard chemotherapy (paclitaxel/Taxol®) and targeted therapy (trastuzumab/Herceptin® and pertuzumab/Perjeta®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®) is the immunotherapy drug used in this study. It is approved to treat bladder cancer and a type of lung cancer. </li> <li class="seamTextUnorderedListItem">The standard of care for HER2+ advanced breast cancer treatment is the chemotherapy drug paclitaxel (Taxol®) and the HER2-targeted drugs trastuzumab (Herceptin®) and pertuzumab (Perjeta®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03125928' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/patients/medicines/tecentriq' target='_blank'>Genentech: Tecentriq</a> </li></ul>
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478

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Consent only)
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT00897702

Helping Researchers Learn Why Tumors Stop Responding to Treatment

Molecular Mechanisms of Clinical Resistance to Targeted Therapy Among Patients With Breast Cancer Scientific Title

Purpose
To study ways molecules in cancer cells change over time and stop responding to treatment.
Who is this for?
People with metastatic (stage IV) breast cancer for whom available therapy is no longer an option. You must be a patient at Memorial Sloan Kettering Cancer Center in New York City.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Blood draw</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Over time, a tumor can stop responding to treatment. </li> <li class="seamTextUnorderedListItem">In lab studies, scientists have found that molecules in cancer cells can change in different ways that result in a tumor no longer responding to treatment. However, it's not known if the same molecules change in every patient. </li> <li class="seamTextUnorderedListItem">The researchers hope to use what they learn from this study to develop and offer more effective treatment to future breast cancer patients.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00897702' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT00897702?term=MSKCC-06163&rank=1' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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479

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge
Basking Ridge,NJ

VISITS: 4 visits over 1 year, then annual visits for 5 years

PHASE: NA

NCT ID: NCT01788839

Sexual and Reproductive Health of Women Treated for Breast Cancer

Longitudinal Sexual and Reproductive Health Study of Women With Breast Cancer and Lymphoma Scientific Title

Purpose
To study how to identify which women are most likely to develop early menopause or sexual problems during cancer therapy, or have difficulty getting pregnant after cancer treatment.
Who is this for?
Women, 50 or younger, diagnosed with DCIS or stage I, stage II, or stage III breast cancer who are within one month of starting treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sexual and Reproductive Health survey, 9 times over 5 years</li> <li class="seamTextUnorderedListItem">If you receive chemotherapy, optional blood draw, 3 times over 2 years</li> <li class="seamTextUnorderedListItem">If you are premenopausal and only receive tamoxifen, blood draws, 12 times over 2 years and transvaginal ultrasound, 2 times, at baseline and 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cancer and its treatment may affect sexual and reproductive health.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling women with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01788839' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.mskcc.org/cancer-care/trial/12-249' target='_blank'>Memorial Sloan Kettering Cancer Center: Study Website</a> </li></ul>
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480

NEAREST SITE: 2539 miles
Memorial Sloan Kettering at Basking Ridge
Basking Ridge,NJ

VISITS: Visits 5 days a week, for 3 weeks

PHASE: II

NCT ID: NCT02422498

Predicting Response to A Combination of Cisplatin & Radiation Therapy in Women with Advanced Triple Negative Breast Cancer

A Phase II Trial of Homologous Recombination Repair Status as a Biomarker of Response in Locally Recurrent/Metastatic Triple Negative Breast Cancer Patients Treated With Concurrent Cisplatin and Radiation Therapy Scientific Title

Purpose
To study if testing a biopsy sample can predict the anti-cancer activity of a combination of the chemotherapy cisplatin and radiation therapy.
Who is this for?
Women with recurrent (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cisplatin (Platinol®), by IV, once a week, for 1-2 weeks</li> <li class="seamTextUnorderedListItem">Followed by radiation therapy, 5 days a week, for 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cisplatin (Platinol®) is a platinum-based chemotherapy drug.</li> <li class="seamTextUnorderedListItem">Radiation therapy can be used to treat cancer cells that have spread to different parts of the body. </li> <li class="seamTextUnorderedListItem">Researchers have developed a test that may predict if your tumor will respond to cisplatin and radiation therapy. </li> <li class="seamTextUnorderedListItem">The test is performed on a biopsy (tissue sample) of the tumor, taken from the breast or elsewhere in the body.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02422498' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/TripleNegativeBreastCancer.html' target='_blank'>Susan G. Komen: Triple Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation/metastatic' target='_blank'>Breastcancer.org: Radiation for Metastatic Breast Cancer</a> </li></ul>
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481

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Consent only)
Basking Ridge,NJ

VISITS: 5 visits over 2 years

PHASE: NA

NCT ID: NCT02743858

Learning Why Some Women Develop Lymphedema After Surgery and Others Do Not

A Prospective Surveillance Program for Assessment and Treatment of Breast Cancer-Related Lymphedema After Axillary Lymph Node Dissection Scientific Title

Purpose
To help researchers learn why only some women develop lymphedema after breast cancer surgery that includes an axillary lymph node dissection.
Who is this for?
Women recently diagnosed with stage I, stage II or stage III breast cancer. You must be planning to have breast cancer surgery that includes the removal of nearby lymph nodes under the arm.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following over 2 years: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">5 arm measurements</li> <li class="seamTextUnorderedListItem">5 height and weight measurements</li> <li class="seamTextUnorderedListItem">5 quality of life questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Breast tissue taken during surgery will be studied for signs of inflammation, which may increase a woman's risk for lymphedema.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a painful swelling of the hand, wrist and/or arm that can occur after breast cancer surgery.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02743858' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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482

NEAREST SITE: 2539 miles
Memorial Sloan Kettering at Basking Ridge (Consent and Follow Up)
Basking Ridge,NJ

VISITS: 1 visit

PHASE: NA

NCT ID: NCT03255577

Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer

Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Patients Presenting With Locally Advanced Breast Cancer: A Prospective Study Scientific Title

Purpose
To study the accuracy of sentinel lymph node biopsy (SLNB) procedure in identifying residual cancer cells in patients who received chemotherapy before surgery (neoadjuvant treatment).
Who is this for?
Women with advanced (stage III) or metastatic (stage IV) breast cancer who are scheduled to begin or have completed neoadjuvant therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sentinel lymph node biopsyy (SLNB) followed by axillary lymph node dissection</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A sentinel lymph node biopsy is used to see if breast cancer cells are found in the sentinel node--the first lymph node under the arm to which the cancer cells are most likely to have spread.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03255577' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/diagnosis-staging/staging/sentinel-node-biopsy-fact-sheet' target='_blank'>Cancer.gov: Sentinel Lymph Node Biopsy</a> </li></ul>
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483

NEAREST SITE: 2539 miles
Memorial Sloan Kettering at Basking Ridge
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03542175

Rucaparib & Radiation in Triple Negative Breast Cancer That Did Not Fully Respond to Chemo

A Phase I Study of Rucaparib Administered Concurrently With Postoperative Radiotherapy in Patients With Triple Negative Breast Cancer With an Incomplete Pathologic Response Following Neoadjuvant Chemotherapy Scientific Title

Purpose
To look at the safety and effects of using rucaparib (Rubraca™) during radiation therapy given after breast surgery.
Who is this for?
Women with stage I, stage II or stage III triple negative (ER-, PR-, HER2-) breast cancer who have cancer cells remaining in her breast or lymph nodes after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rucaparib (Rubraca™), by mouth, twice a day, for 2.5 months</li> <li class="seamTextUnorderedListItem">Radiation, for 1.5 months (number of sessions not available)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rubraca is a type of targeted therapy called a PARP (poly ADP ribose polymerase) inhibitor. It is approved to treat women with advanced ovarian cancer whose tumors have a BCRA mutation. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03542175' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/rucaparib.aspx' target='_blank'>Chemocare: Rucaparib</a> </li></ul>
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484

NEAREST SITE: 2539 miles
Memoral Sloan Kettering Basking Ridge
Basking Ridge,NJ

VISITS: 1 visit every other day for 6 or 10 days, then visits coincide with standard treatment

PHASE: II

NCT ID: NCT03808662

SBRT Radiation Therapy for Oligoprogressive Metastatic Breast Cancer

A Randomized Phase II Study Assessing the Efficacy of Local Ablative Radiation Therapy for Metastatic Breast and Lung Cancer Patients With Oligoprogressive Disease Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using stereotactic body radiation therapy (SBRT) to treat each site of metastases.
Who is this for?
People with oligoprogessive metastatic (stage IV) triple negative (ER-, PR- and HER2-) or hormone receptor positive (ER+ and/or PR+) breast cancer that has progressed on at least one other systemic treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic body radiation therapy (SBRT), every other day, for 3 or 5 sessions</li> <li class="seamTextUnorderedListItem">followed by standard of care treatment (decided by you and your physician)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care treatment (decided by you and your physician)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Patients with oligoprogressive metastatic breast cancer have a small number of metastatic tumors in one or two other parts of the body. </li> <li class="seamTextUnorderedListItem">This study will compare the safety and effects (good or bad) of using stereotactic body radiation therapy (SBRT) to treat each site of metastases followed by a standard of care treatment, to a standard of care treatment alone. </li> <li class="seamTextUnorderedListItem">SBRT uses multiple radiation beams to deliver high doses of precision radiation directly to the tumor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03808662' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.uclahealth.org/radonc/faqs-sbrt' target='_blank'>UCLA Health: SBRT FAQs</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/diagnosis-treatment/cancer-treatments/radiation-therapy/what-sbrt' target='_blank'>Memorial Sloan Kettering Cancer Center: What is SBRT?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oligometastasis' target='_blank'>NCI Dictionary of Cancer Terms: Oligometastasis</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/clinical-trials/18-431' target='_blank'>Memorial Sloan Kettering Cancer Center: Study information</a> </li></ul>
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485

NEAREST SITE: 2539 miles
Memoral Sloan Kettering Basking Ridge
Basking Ridge,NJ

VISITS: Daily visits for 3 days

PHASE: II

NCT ID: NCT04084730

Three Days of Radiation Therapy in Women with DCIS or Stage I Breast Cancer

Ultra-Short External Beam-Based Accelerated Partial Breast Irradiation (APBI): A Phase II Toxicity Study Nested With a Non-inferiority Assessment of APBI in New Patient Cohorts Scientific Title

Purpose
To study the effects (good and bad) of three days of accelerated partial breast irradiation (APBI) after a lumpectomy.
Who is this for?
Women with ductal carcinoma in situ (DCIS) or stage I breast cancer who have had a lumpectomy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Accelerated Partial Breast Irradiation (APBI), daily, for 3 days</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Three days is a shorter course of radiation than patients would typically receive.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04084730' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/apbr-vs-wbr-for-lower-recurrence-risk-after-lx' target='_blank'>Breastcancer.org: Accelerated Partial-Breast Radiation Slightly Less Effective Than Whole-Breast Radiation for Preventing Breast Cancer Recurrence After Lumpectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2018/breast-cancer-radiation-therapy-whole-partial-recurrence' target='_blank'>Cancer.gov: Whole- and Partial-Breast Radiation Effective at Preventing Breast Cancer from Returning</a> </li></ul>
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486

NEAREST SITE: 2539 miles
Memoral Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge,NJ

VISITS: Coincides with surgery

PHASE: III

NCT ID: NCT04241341

Axillary Lymph Node Dissection with or without Immediate Lymph Reconstruction to Prevent Lymphedema

A Randomized Controlled Trial: Does Immediate Lymphatic Reconstruction Decrease the Incidence of Lymphedema After Axillary Lymph Node Dissection Scientific Title

Purpose
To study whether having immediate lymphatic reconstruction (ILR) during an axillary lymph node dissection (removal of lymph nodes from the underarm area) reduces a woman's risk of developing lymphedema.
Who is this for?
Women planning to have an axillary lymph node dissection.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND)</li> <li class="seamTextUnorderedListItem">Lymphatic reconstruction immediately following your ALND</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Quality of life questionnaires</li> <li class="seamTextUnorderedListItem">Standard lymphedema measurements, every 6 months for 2 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a painful swelling of the hand, wrist, or arm that can occur after breast cancer surgery. </li> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND) is a surgical procedure done to see if the cancer has spread to the lymph nodes located in your armpit (axilla). It can increase your risk for lymphedema. </li> <li class="seamTextUnorderedListItem">Immediate lymphatic reconstruction is a procedure that will be performed immediately after your ALND and is designed to improve lymphatic drainage.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04241341' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/surgery-for-breast-cancer/lymph-node-surgery-for-breast-cancer.html' target='_blank'>American Cancer Society: Lymph Node Surgery for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/oncolog/advances-in-surgical-management-of-lymphedema.h13-1591413.html' target='_blank'>MD Anderson Cancer Center: Advances in Surgical Management of Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/lymphedema-what-are-your-surgical-options' target='_blank'>Johns Hopkins Medicine: Lymphedema, What Are Your Surgical Options?</a> </li></ul>
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487

NEAREST SITE: 2549 miles
Rutgers Cancer Institute of New Jersey
New Brunswick,NJ

VISITS: 1 visit every 3 weeks, ongoing

PHASE: II

NCT ID: NCT03428802

Immunotherapy Pembrolizumab for Advanced Breast Cancer in People With a BRCA1/2 Tumor Mutation

A Basket Trial of Pembrolizumab in Patients With Advanced Solid Tumors and Genomic Instability Scientific Title

Purpose
To study the effects (good and bad) of using the PD-1 inhibitor pembrolizumab (Keytruda®) in breast cancer with a BRCA1/2 tumor mutation.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have been tested for and found to have a BRCA 1 or BRCA 2 tumor (not inherited) mutation or a POLE or POLD1 mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy drug is pembrolizumab (Keytruda®). </li> <li class="seamTextUnorderedListItem">Keytruda® is a type of immunotherapy drug called a PD-1 inhibitor. It gets the immune system to go after cancer cells by blocking a protein called programmed cell death (PD-1). </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancers.</li> <li class="seamTextUnorderedListItem">Targets or mutations: BRCA1/2 tumor (not inherited), POLE, POLD1</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03428802' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/issues/july-10-2017/pembrolizumab-moving-forward-in-triple-negative-breast-cancer/' target='_blank'>ASCO: Keytruda for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.curetoday.com/articles/parp-inhibitor-may-prolong-survival-in-metastatic-brcapositive-breast-cancer' target='_blank'>Cure Today: Parp Inhibitor May Prolong Survival</a> </li></ul>
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488

NEAREST SITE: 2549 miles
Rutgers Cancer Institute of New Jersey
New Brunswick,NJ

VISITS: 3 visits a month, ongoing

PHASE: II

NCT ID: NCT04090398

Paclitaxel Alone or With Radium-223 Dichloride For Metastatic HER2 Negative Breast Cancer With Bone Metastases

Phase II Trial of Radium-223 Dichloride in Combination With Paclitaxel in Patients With Bone Metastatic Breast Cancer Scientific Title

Purpose
To study the anti-cancer activity and effects (good and bad) of giving radium-223 dichloride (a type of radiation therapy given by IV) in combination with paclitaxel (Taxol®).
Who is this for?
People with metastatic (stage IV), HER2 negative (HER2-) breast cancer that has spread to the bone and who have not received more than three lines of chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Radium 223 dichloride (Xofigo®), by IV, once a month, for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy drug routinely used to treat metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">Radium-223 dichloride (Xofigo®) is a radiation therapy given by IV. It works by killing cancer cells and may reduce the pain caused by bone metastases. </li> <li class="seamTextUnorderedListItem">Radium-223 dichloride (Xofigo®) is approved to treat metastatic prostate cancer that has spread to the bones. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04090398' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/oral-vs-iv-paclitaxel-for-mbc' target='_blank'>Breastcancer.org: Is Oral Paclitaxel Better Than IV Paclitaxel for Metastatic Breast Cancer?</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/radium-223-dichloride.aspx' target='_blank'>Chemocare: Radium 223 Dichloride</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Radium-223' target='_blank'>Wikipedia: Radium-223</a> </li><li class='seamTextUnorderedListItem'><a href='http://mbcn.org/bone-mets/' target='_blank'>Metastatic Breast Cancer Network: Bone Mets</a> </li></ul>
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489

NEAREST SITE: 2549 miles
Rutgers Cancer Institute of New Jersey
New Brunswick,NJ

VISITS: 5 visits per month, ongoing

PHASE: II

NCT ID: NCT04445844

Immunotherapies MGA012 and Pelareorep for Advanced Triple Negative Breast Cancer

IRENE Study: Phase 2 Study of INCMGA00012 and the Oncolytic Virus Pelareorep in Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To study the safety and anti-cancer activity of combining the experimental checkpoint inhibitor MGA012 with the immunotherapy pelareorep.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have received one to three prior therapies for advanced disease.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pelareorep, by IV, 2 days a week, every other week, ongoing</li> <li class="seamTextUnorderedListItem">MGA012 (Retifanlimab), by IV, once a month, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MGA012 (Retifanlimab) is a type of immunotherapy called a checkpoint inhibitor. It gets the immune system to go after cancer cells by blocking the protein PD-1.</li> <li class="seamTextUnorderedListItem">Pelareorep is an oncolytic virus--this means it targets and kills cancer cells. It may directly kill cancer cells and stimulate your immune system to go after and kill cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04445844' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.macrogenics.com/mga012-pd-1/' target='_blank'>Macrogenics Drug Information Page: Retifanlimab (MGA012)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-pd-1-monoclonal-antibody-mga012' target='_blank'>NCI Drug Dictionary: MGA012</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Pelareorep' target='_blank'>Wikipedia: Pelareorep</a> </li></ul>
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490

NEAREST SITE: 2561 miles
Memorial Sloan Kettering Bergen (Consent and follow-up only)
Montvale,NJ

VISITS: At least 2 visits over 2-3 months; includes hospital stay for at least 2 days

PHASE: I

NCT ID: NCT02792114

Mesothelin-Targeted CAR T-Cell Immunotherapy for Metastatic HER2 Negative Breast Cancer

A Phase I Clinical Trial to Evaluate the Safety and Tolerability of Mesothelin-Specific Chimeric Antigen Receptor-Positive T Cells in Patients With Metastatic Mesothelin-Expressing Breast Cancer (CAR-T therapy) Scientific Title

Purpose
To study the safety and best dose of a CAR T-cell immunotherapy made from your own T-cells.
Who is this for?
Women with metastatic (stage IV) HER2 negative (HER2-) breast cancer. You must have been previously treated with at least one chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leukapheresis (blood draw for the collection of cells)</li> <li class="seamTextUnorderedListItem">Acetaminophen and diphenhydramine</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®), by IV, 2 to 7 days before you receive your CAR T-cell therapy</li> <li class="seamTextUnorderedListItem">Mesothelin-targeted CAR T-cell therapy, by IV, while you are in the hospital for at least 2 days</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immune system has two types of white blood cells, B cells and T cells. </li> <li class="seamTextUnorderedListItem">Mesothelin is a protein commonly found in breast cancer cells. </li> <li class="seamTextUnorderedListItem">The mesothelin-targeted CAR T-cells can get to the cancer cells by attaching itself to these proteins.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02792114' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/about-cancer/treatment/research/car-t-cells' target='_blank'>NCI Research Article: CAR T-Cell Therapy</a> </li></ul>
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491

NEAREST SITE: 2561 miles
Memorial Sloan Kettering Bergen
Montvale,NJ

VISITS: Number of visits unavailable, over 2 years

PHASE: NA

NCT ID: NCT00579488

Identifying Different Types of BRCA1 and BRCA2 Mutations

Clinical Significance of Germline BRCA Mutations Scientific Title

Purpose
To identify the range of BRCA mutations found in people who have genetic testing, to better understand the different types of BRCA1 and BRCA2 mutations that increase cancer risk.
Who is this for?
People, including those without breast cancer, who are planning to have a genetic counseling consultation at Memorial Sloan-Kettering Cancer Center in New York City.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will undergo blood tests</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">People who inherit a mutation in the genes known as BRCA1 and BRCA2 are at increased risk of developing breast cancer. </li> <li class="seamTextUnorderedListItem">To be eligible, participants must have a genetic counseling consultation at Memorial Sloan-Kettering Cancer Center in New York City.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00579488' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.net/all-about-cancer/genetics/genetics-breast-cancer' target='_blank'>Cancer.Net: Genetics of Breast Cancer</a> </li></ul>
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492

NEAREST SITE: 2561 miles
Memorial Sloan Kettering Bergen
Montvale,NJ

VISITS: 8 to 10 times for 2-3 years, then once a year for 2-3 years

PHASE: NA

NCT ID: NCT00823654

Measuring Hormone Levels to Study How Cancer Treatments & Inherited BRCA 1/2 Mutations Affect The Ovaries

Multi-Center Study of Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer and Lymphoma Scientific Title

Purpose
To study if a blood test that measures hormones can predict who will enter early menopause or develop fertility issues because of how chemotherapy and hormone therapy affect the ovaries; and to study the fertility and sexual health of women with inherited BRCA 1 or BRCA 2 mutations.
Who is this for?
Premenopausal women, 44 or younger, with DCIS or stage I, stage II, or stage III breast cancer planning to receive chemotherapy or tamoxifen. You may also enroll if you do not have breast cancer but have an inherited BRCA 1 or BRCA 2 mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Women with DCIS or stage I-III breast cancer</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws, 8-10 times for 2-3 years, then once a year for 2-3 years (5 years total)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Women with inherited BRCA mutations</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws, 5 times for the first year, then optional draws once a year for 4 years (5 years total)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer treatments can affect the ovaries, which may cause early menopause or difficulty becoming pregnant. </li> <li class="seamTextUnorderedListItem">Ovarian functioning can be assessed by evaluating the blood levels of certain hormones the ovaries produce.</li> <li class="seamTextUnorderedListItem">Inherited BRCA 1/2 mutations may affect your ovaries.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00823654' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youngsurvival.org' target='_blank'>Young Survival Coalition</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.facingourrisk.org/index.php' target='_blank'>FORCE: Facing Our Risk of Cancer Empowered</a> </li></ul>
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493

NEAREST SITE: 2561 miles
Memorial Sloan Kettering Bergen (Consent and Follow-Up)
Montvale,NJ

VISITS: At least 2 visits over 3-6 weeks; may include hospital stay

PHASE: I-II

NCT ID: NCT02414269

CAR T-Cell Immunotherapy for Metastatic Breast Cancer That Has Spread to the Pleura

A Phase I Clinical Trial of Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin Scientific Title

Purpose
To study the safety and effects (good and bad) of using a new type of CAR T-cell immunotherapy.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the pleura.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: CAR T-Cells only</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leukapheresis (blood draw for the collection of cells) <i class="seamTextEmphasis">followed 3-6 weeks later by:</i></li> <li class="seamTextUnorderedListItem">Acetaminophen and diphenhydramine, by mouth or by IV </li> <li class="seamTextUnorderedListItem">iCasp9M28z CAR T-cells, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: CAR T-Cells with chemotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leukapheresis (blood draw for the collection of cells) <i class="seamTextEmphasis">followed 3-6 weeks later by:</i></li> <li class="seamTextUnorderedListItem">Acetaminophen and diphenhydramine, by mouth or by IV</li> <li class="seamTextUnorderedListItem">iCasp9M28z CAR T-cells, by IV</li> <li class="seamTextUnorderedListItem">Cyclophosphamide, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Hospital stay may be required.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CAR T-cell therapy is a personalized immunotherapy made from your own white blood cells. </li> <li class="seamTextUnorderedListItem">The blood cells are removed from you, and then modified with chimeric antigen receptors (CARs) so they can attack specific proteins. </li> <li class="seamTextUnorderedListItem">The cells are then infused back into you while you are hospitalized. </li> <li class="seamTextUnorderedListItem">The pleura is the thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity. </li> <li class="seamTextUnorderedListItem">This CAR T-cell therapy is designed to target proteins found on cancer cells in the pleura.</li> <li class="seamTextUnorderedListItem">The CAR T-cell therapy is given along with acetaminophen and diphenhydramine. These drugs are used to prevent infusion-related reactions.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02414269' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.drsusanloveresearch.org/videos/chimeric-antigen-receptor-t-cell-car-t-therapy' target='_blank'>Dr. Susan Love Research Foundation: Chimeric Antigen Receptor T-Cell (CAR-T) Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744527/' target='_blank'>Pubmed: Mesothelin-Targeted CARs: Driving T cells to Solid Tumors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.targetedonc.com/publications/targeted-therapy-news/2018/august-2018/early-signs-of-efficacy-seen-with-mesothelin-car-tcell-therapy' target='_blank'>Targeted Oncology: Early Signs of Efficacy Seen With Mesothelin CAR T-Cell Therapy</a> </li></ul>
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494

NEAREST SITE: 2566 miles
Memorial Sloan Kettering Monmouth
Middletown,NJ

VISITS: 4 visits over the first 2 months, then monthly visits thereafter

PHASE: I-II

NCT ID: NCT02605486

Palbociclib & Bicalutamide for Women with Metastatic Triple Negative Breast Cancer that is Androgen Receptor Positive

Palbociclib in Combination With Bicalutamide for the Treatment of AR(+) Metastatic Breast Cancer (MBC) Scientific Title

Purpose
To look at the safety and anti-cancer activity of using the CDK 4/6 inhibitor palbociclib (Ibrance®) in combination with the anti-androgen drug bicalutamide (Casodex®).
Who is this for?
Women with metastatic (stage (IV) triple negative (ER-, PR-, HER2-) breast cancer that is androgen-receptor positive.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bicalutamide (Casodex®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a targeted therapy that keeps cancer cells from growing by blocking two enzymes, CDK 4 and CDK 6. It is used to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Bicalutamide (Casodex®) is an anti-androgen drug used to treat prostate cancer. </li> <li class="seamTextUnorderedListItem">Some breast cancers test positive for androgen receptors. </li> <li class="seamTextUnorderedListItem">Targets or mutations: AR (androgen receptor)</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02605486' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/targeted_therapies/ibrance' target='_blank'>Breastcancer.org: Ibrance</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancerresearchuk.org/about-cancer/cancers-in-general/treatment/cancer-drugs/bicalutamide' target='_blank'>Cancer Research UK: Bicalutamide</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/issues/june-10-2017/targeting-the-androgen-receptor-in-breast-cancer/' target='_blank'>ASCO: Targeting the Androgen Receptor in Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li></ul>
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495

NEAREST SITE: 2567 miles
Memorial Sloane Kettering Cancer Center
New York,NY

VISITS: Coincides with risk assessment

PHASE: II

NCT ID: NCT02653755

Lumpectomy Without Radiation for Individuals at Low-Risk of Cancer Coming Back

The PRECISION Trial (Profiling Early Breast Cancer for Radiotherapy Omission): A Phase II Study of Breast-Conserving Surgery Without Adjuvant Radiotherapy for Favorable-Risk Breast Cancer Scientific Title

Purpose
To see whether women who are at low risk of having their cancer come back can skip radiation.
Who is this for?
Women between the ages of 50 and 75 who have had a lumpectomy for early stage (stage I, stage II or stage III) breast cancer. Your tumor must be hormone (ER+ and/or PR+) receptor positive and HER2 negative.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intermediate or High Risk</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Receive radiation therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Low Risk</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No radiation therapy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Most women receive radiation therapy after a lumpectomy (also called breast conserving surgery). </li> <li class="seamTextUnorderedListItem">Prosigna is a genetic test used on tumor tissue. It tells you how likely it is your breast cancer will come back in a location other than your breast (called a distant recurrence or metastases).</li> <li class="seamTextUnorderedListItem">If your Prosigna score is high or intermediate, you will recieve radtion therapy.</li> <li class="seamTextUnorderedListItem">If your Prosigna score is low, you may chose to not recieve radiation therapy. </li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02653755' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/study/NCT02653755?term=NCT02653755&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/testing/types/prosigna' target='_blank'>Breastcancer.org: Prosigna Test</a> </li></ul>
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496

NEAREST SITE: 2567 miles
Lenox Hill Brain Tumor Center
New York,NY

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT02571530

Herceptin for HER2-Positive Breast Cancer That Has Spread to the Brain

Phase 1 Trial of Super-selective Intra-arterial Cerebral Infusion of Trastuzumab After Blood-Brain Barrier Disruption for the Treatment of Cerebral Metastases of HER2/Neu Positive Breast Cancer Scientific Title

Purpose
To evaluate the safety of administering a single dose of trastuzumab into an artery in the brain to treat brain metastases.
Who is this for?
Women with stage I, stage II, or stage III HER2 positive breast cancer who have completed chemotherapy between 6 months and 36 months ago.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive a single infusion of trastuzumab (Herceptin®) into arteries in the brain (Intra-arterial Cerebral Infusion).</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) is used to treat HER2 positive breast cancer. </li> <li class="seamTextUnorderedListItem">It is delivered intravenously. </li> <li class="seamTextUnorderedListItem">However, the blood-brain barrier prevents much of the drug from getting to cancer cells that have spread to the brain.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02571530' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://ascopubs.org/doi/full/10.1200/JCO.2012.44.8894' target='_blank'>JCO: Intrathecal Trastuzumab</a> </li></ul>
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497

NEAREST SITE: 2567 miles
Mount Sinai Downtown
New York,NY

VISITS: Visits every 3 weeks

PHASE: II

NCT ID: NCT02531932

Carboplatin and Afinitor for Women with Metastatic Triple Negative or ER-Low Breast Cancer

A Multi-Centered Randomized Phase II Study Comparison of Single-Agent Carboplatin vs the Combination of Carboplatin and Everolimus for the Treatment of Advanced Triple-Negative Breast Cancer Scientific Title

Purpose
To compare the safety and effects (good and bad) of carboplatin and Afinitor to carboplatin alone.
Who is this for?
Women with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or ER-Low (1%-10% ER) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paraplatin (Carboplatin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paraplatin (Carboplatin®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Paraplatin (Carboplatin®) is a platinum-based chemotherapy drug used to treat metastatic breast cancer that has not responded to previous treatments. </li> <li class="seamTextUnorderedListItem">Everolimus (Afinitor®) is a type of targeted therapy called an mTOR inhibitor. It works by interfering with a cancer cell's ability to divide and grow.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02531932' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancernetwork.com/news/new-approaches-triple-negative-breast-cancer' target='_blank'>CancerNetwork: New Approaches for TNBC</a> </li></ul>
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498

NEAREST SITE: 2567 miles
Memorial Sloan Kettering Cancer Center
New York,NY

VISITS: 1-2 visits

PHASE: NA

NCT ID: NCT01916122

A New Approach to Studying How ER+ Tumors Respond to Treatment

Fluorestradiol (FES) PET/CT for Imaging Estrogen Receptor Status Scientific Title

Purpose
To explore the use of FES with a PET/CT scan in women who have ER+ breast cancer and have not yet received hormone therapy.
Who is this for?
People with estrogen receptor positive stage I, stage II, stage III, or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will undergo FES PET/CT scanning, up to 1 hour per scanning session.</p>
  • <p class="seamTextPara"> Breast cancer tumors are tested to determine if they are estrogen receptor (ER) positive or negative. Those that are ER+ can be treated with an anti-estrogen therapy. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A positron emission tomography (PET) scan is an imaging test that uses a radioactive substance called a tracer that can look for and attach to cancer cells. </li> <li class="seamTextUnorderedListItem">A tracer called 16a-18F-fluoroestradiol (FES) looks for and attaches to estrogen receptors. Researchers think that it may be possible to use FES to monitor the effect that a cancer treatment is having on the breast tumor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01916122' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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499

NEAREST SITE: 2567 miles
Weill Cornell Medical College
New York,NY

VISITS: 15 visits over 3 weeks

PHASE: I-II

NCT ID: NCT02917421

Lymph Node Radiation For Early Stage Breast Cancer After Surgery

Accelarated Radiation Therapy (ART) to the Breast and Nodal Stations After Neo-adjuvant Chemotherapy and Surgery : A Feasibility Study. Scientific Title

Purpose
To compare the safety and effects (good and bad) and effectiveness of 15 sessions of standard radiation to the breast and chest wall with 15 sessions of radiation to breast, chest wall and surrounding lymph nodes.
Who is this for?
Women with stage I, stage II or stage III breast cancer who had chemotherapy before surgery, has completed surgery, and will be having radiation therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation to breast and chest wall, 15 sessions over 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation to breast, chest wall, and surrounding lymph nodes, 15 sessions over 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is comparing the safety and effects (good and bad) and effectiveness of 15 sessions of standard radiation to the breast and chest wall with 15 sessions of radiation to breast, chest wall and surrounding lymph nodes.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02917421' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph_node_removal/axillary_dissection' target='_blank'>Breastcancer.org: Axillary Lymph Node Dissection</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph_node_removal/importance' target='_blank'>Breastcancer.org: Why Are Lymph Nodes Important?</a> </li></ul>
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500

NEAREST SITE: 2567 miles
Mount Sinai Beth Israel Comprehensive Cancer Center West
New York,NY

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03304080

Arimidex, Ibrance, Herceptin and Perjeta for HR+, HER2+ Metastatic Breast Cancer

A Multicenter, Phase I/II Trial of Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HeR-positive, Her2-positive Metastatic Breast Cancer Scientific Title

Purpose
To study the safety and effects (good and bad) of using two anti-estrogen therapies and two HER2-targeted therapies to treat HR+, HER2+ metastatic breast cancer.
Who is this for?
Women with metastatic (stage IV) breast cancer that is estrogen receptor positive and HER2 positive. You must not have received any prior anti-cancer-treatment for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Anastrozole (Armidex®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks</li></ul>
  • <p class="seamTextPara"> The anti-estrogen therapies being used in this study are palbociclib (Ibrance®) and anastrozole (Arimidex®). </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The HER2-targeted therapies are trastuzumab (Herceptin®) and pertuzumab (Perjeta®). </li> <li class="seamTextUnorderedListItem">All four therapies are approved to treat metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03304080' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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501

NEAREST SITE: 2567 miles
Mount Sinai Beth Israel
New York,NY

VISITS: Number of visits varies, over 5 months before surgery, then 1 visit every 3 weeks for 9 months

PHASE: II

NCT ID: NCT03329378

Dose Dense Chemotherapy Before Surgery For Stage II-III HER2 Positive Breast Cancer

A Phase II Randomized Trial Evaluating Neoadjuvant Dose-Dense Doxorubicin/Cyclophosphamide Followed by Paclitaxel/Trastuzumab/Pertuzumab (AC THP) and Docetaxel/Carboplatin/Trastuzumab/Pertuzumab (TCHP) For Early Her2Neu Positive Breast Cancer Scientific Title

Purpose
To compare the anti-cancer activity and side-effects of dose-dense chemotherapy to standard of care chemotherapy given before surgery.
Who is this for?
Women with stage II, stage IIIA or stage IIIB/C (locally advanced) HER2 positive (HER2+) or inflammatory breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and receive the following before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Dose-dense chemotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AC (Doxorubicin (Adriamycin®) and Cyclophosphamide (Cytoxan®), by IV, every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">Pegfilgrastim (Neulasta®), by injection, every 2 weeks, for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, once a week, for 3 months</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, once every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, once every 3 weeks, to continue after surgery, for 1 year total</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard chemotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">TCHP (Taxotere®, Carboplatin, Herceptin®, Perjeta®), by IV, once every 3 weeks, for 5 months</li> <li class="seamTextUnorderedListItem">Pegfilgrastim (Neulasta®), by injection, once every 3 weeks, for 5 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, please contact research site for the treatment schedule</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, once every 3 weeks, to continue after surgery, for 1 year total</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">One regimen will include doxorubicin and cyclophosphamide followed by paclitaxel, trastuzumab, and pertuzumab. </li> <li class="seamTextUnorderedListItem">The other will include docetaxel, carboplatin, trastuzumab, and pertuzumab.</li> <li class="seamTextUnorderedListItem">Doxorubicin (Adriamycin®), cyclophosphamide (Cytoxan®), docetaxel (Taxotere®), paclitaxel (Taxol® ), and carboplatin (Paraplatin®) are chemotherapy drugs used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) and Pertuzumab (Perjeta®) are HER2 targeted therapies used to treat HER2+ breast cancer. </li> <li class="seamTextUnorderedListItem">Pegfilgrastim (Neulasta®) is a drug that can stimulate the body to produce more white blood cells. It is routinely used to reduce the risk of infection in patients receiving chemotherapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03329378' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/chemotherapy-for-breast-cancer.html' target='_blank'>American Cancer Society: Dose-dense chemotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/chemotherapy/process/when' target='_blank'>Breastcancer.org: Dose-dense chemotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2018-03595&r=1' target='_blank'>Cancer.gov: Trial summary</a> </li></ul>
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502

NEAREST SITE: 2567 miles
Weill Cornell Medicine
New York,NY

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03449238

Pembrolizumab (Immunotherapy) And Radiosurgery (Radiation) to Treat Brain Metastases

Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients Scientific Title

Purpose
To study the safety and effects (good and bad) of using pembrolizumab (Keytruda®) along with stereotactic radiosurgery (SRS) to treat breast cancer that has spread to the brain.
Who is this for?
Women with metastatic (stage IV) breast cancer and at least two brain metastases.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks, ongoing</li> <li class="seamTextUnorderedListItem">Stereotactic Radiosurgery (SRS), once after the first treatment of pembrolizumab</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor.</li> <li class="seamTextUnorderedListItem">It stimulates the body's immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">It has been approved to treat certain types of cancer, but its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery is not surgery. It is a type of radiation therapy that precisely targets metastases in the brain.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03449238' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.brainmetsbc.org/' target='_blank'>BrainMetsBC.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/types/recur_metast/treat_metast/options/local/brain/radiosurgery' target='_blank'>Breastcancer.org: Stereotactic Radiosurgery for Brain Metastasis</a> </li></ul>
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503

NEAREST SITE: 2567 miles
New York Presbyterian Hospital at Lower Manhattan Cancer Center
New York,NY

VISITS: 5 visits a week, for 2 or 3 weeks

PHASE: III

NCT ID: NCT04175210

Comparing Two Whole Breast Radiation Schedules in Women with DCIS or Stage I-II Breast Cancer

Prospective Randomized Study of Accelerated Radiation Therapy (PRART) Scientific Title

Purpose
To compare the effects (good and bad) of two whole breast radiation and tumor bed boost schedules.
Who is this for?
Women with DCIS or stage I or stage II node-negative (no cancer cells were found in your lymph nodes) breast cancer who had a lumpectomy (breast conserving surgery) with clear margins (cancer free area around tumor).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard schedule</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Whole breast radiation, 5 days a week, for 3 weeks</li> <li class="seamTextUnorderedListItem">Followed by boost to tumor bed</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental schedule</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Whole breast radiation, 5 days a week, for 2 weeks</li> <li class="seamTextUnorderedListItem">Followed by boost to tumor bed</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation is typically given five days a week, for three to six weeks. </li> <li class="seamTextUnorderedListItem">Accelerated Radiation Therapy is given five days a week for two weeks. </li> <li class="seamTextUnorderedListItem">The radiation boost to the tumor bed is given after whole breast radiation is completed. </li> <li class="seamTextUnorderedListItem">The boost delivers radiation specifically to the area of the breast where the tumor was removed.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04175210' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/radiation-for-breast-cancer.html' target='_blank'>American Cancer Society: Radiation for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/GoingThroughRadiationTherapy.html' target='_blank'>Susan G. Komen: Going Through Radiation Therapy</a> </li></ul>
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504

NEAREST SITE: 2568 miles
NYU Perlmutter Cancer Center
New York,NY

VISITS: Visits weekly

PHASE: NA

NCT ID: NCT02752685

Keytruda and Abraxane in HER2 Negative Metastatic Breast Cancer

Phase II Study of Pembrolizumab and Nab-paclitaxel in HER-2 Negative Metastatic Breast Cancer Scientific Title

Purpose
To study the safety and effects of using a chemotherapy drug along with Keytruda immunotherapy.
Who is this for?
Women with metastatic (stage IV) breast cancer that is either triple negative (ER-, PR-, HER2-) or estrogen receptor positive and HER2 negative.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Taxotere®), by IV, weekly, 2 weeks on 1 week off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers are trying to see which treatment combinations are best for HER2-negative breast cancer. </li> <li class="seamTextUnorderedListItem">The chemotherapy drug is nab-paclitaxel (Abraxane®), which is used to treat advanced breast cancer. </li> <li class="seamTextUnorderedListItem">The immunotherapy drug is pembrolizumab (Keytruda®), which gets the immune system to fight cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02752685' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02752685?term=NCT02752685&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li></ul>
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505

NEAREST SITE: 2568 miles
Mount Sinai West
New York,NY

VISITS: Number of visits unavailable, over 3 weeks

PHASE: I

NCT ID: NCT02936206

Tamoxifen and Faslodex Before Surgery in Premenopausal Women with ER+ Breast Cancer

Comparison in the Change of Proliferation Index Between Fulvestrant and Tamoxifen in Cyclin D1 +, Estrogen Receptor + Breast Cancer Scientific Title

Purpose
To look at the effect that two different types of anti-estrogen drugs have on breast cancer cells in premenopausal women.
Who is this for?
Women who are premenopausal and newly diagnosed with estrogen receptor positive (ER+), HER2 negative breast cancer. You must be scheduled to have surgery at Mount Sinai Hospital in New York and your tumor must be cyclin D1-positive and at least 5 mm in size.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and receive the following treatment before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), 3 injections on day 1</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®), by mouth, daily for 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two drugs being studied are tamoxifen (Nolvadex®) and fulvestrant (Faslodex®). </li> <li class="seamTextUnorderedListItem">Both are used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">Giving the drugs before surgery allows the researchers to study the effect they have on breast cancer cells.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02936206' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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506

NEAREST SITE: 2568 miles
NYU Langone Health
New York,NY

VISITS: 1-2 visits a week for 5-6 months, before surgery

PHASE: II

NCT ID: NCT03742986

Immunotherapy Nivolumab & Chemotherapy Before Surgery for Inflammatory Breast Cancer

Phase II Trial of Nivolumab With Chemotherapy as Neoadjuvant Treatment in Inflammatory Breast Cancer (IBC) Scientific Title

Purpose
To look at the effect of adding the immunotherapy drug nivolumab (Opdivo®) to chemotherapy routinely used before surgery (neoadjuvant treatment).
Who is this for?
People with newly diagnosed inflammatory breast cancer who have not yet started treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups depending on the HER2 status of your tumor, and will receive the following treatment before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis"><u>Group 1: HER2 Negative</u></i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, every week, for 3 months</li> </ul> <p class="seamTextPara"> Then you will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doxorubicin (Doxil®), by IV, every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®), by IV, every 2 weeks, for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis"><u>Group 2: HER2 Positive</u></i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, every week, for 3 months OR Docetaxel (Taxotere®) every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks, for 3 months</li> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®), by IV, every 3 weeks, for 3 months</li> </ul> <p class="seamTextPara"> Then you will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Doxorubicin (Doxil®), by IV, every 2 weeks, for 2 months</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®), by IV, every 2 weeks, for 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®) is a type of immunotherapy called a PD-1 inhibitor. </li> <li class="seamTextUnorderedListItem">It gets the immune system to go after cancer cells by blocking a protein called PD-1 (programmed cell death 1). </li> <li class="seamTextUnorderedListItem">It is approved to treat certain types of cancer. </li> <li class="seamTextUnorderedListItem">Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03742986' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/immunotherapy' target='_blank'>Breastcancer.org: Immunotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.opdivo.com/' target='_blank'>Bristol-Meyers Squibb Information Page: Opdivo® (Nivolumab)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/chemotherapy-for-breast-cancer.html' target='_blank'>American Cancer Society: Chemotherapy for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/sabcs-2018/association-between-pcr-and-neoadjuvant-chemo-shows-improved-breast-cancer-outcomes' target='_blank'>OncLive: Association Between pCR and Neoadjuvant Chemo Shows Improved Breast Cancer Outcomes</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.theibcnetwork.org/' target='_blank'>The IBC Network Foundation: What is Inflammatory Breast Cancer?</a> </li></ul>
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507

NEAREST SITE: 2569 miles
Columbia University Medical Center - Herbert Irving Cancer Center
New York,NY

VISITS: Number of visits unavailable, over 2 weeks

PHASE: NA

NCT ID: NCT01980823

Metformin & Atorvastatin Before Surgery to Study Their Effect on Cancer Cells

Pre-Surgical "Window of Opportunity" Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer Scientific Title

Purpose
To study the effects of metformin and atorvastin on breast cancer cells.
Who is this for?
Women with stage I, stage II, stage III, or stage IV (metastatic) breast cancer or DCIS.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metformin and atorvastatin, by mouth, daily, for 2 weeks prior to surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metformin is a medication used to treat patients with diabetes.</li> <li class="seamTextUnorderedListItem">Atorvastatin is used to treat high cholesterol.</li> <li class="seamTextUnorderedListItem">By giving these drugs before surgery--called neoadjuvant treatment--researchers can study the effect that they have on breast cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01980823' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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508

NEAREST SITE: 2569 miles
Columbia University Medical Center
New York,NY

VISITS: 3 visits over 2 months

PHASE: I

NCT ID: NCT02977468

Neoadjuvant Keytruda and Radiation Therapy for Stage I-III, Triple Negative Breast Cancer

Effects of MK-3475 (Pembrolizumab) on the Breast Tumor Microenvironment in Triple Negative Breast Cancer With and Without Intra-operative RT: a Window of Opportunity Study Scientific Title

Purpose
To study how pembrolizumab (Keytruda®) affects cancer cells, the healthy tissue surrounding tumors (the microenvironment), the immune system, and intraoperative radiation therapy.
Who is this for?
Women with stage I, stage II, or stage III triple negative (ER-, PR-, HER2-) breast cancer who have not yet received any treatment for their cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, 1 or 2 times before surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Followed by</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiation therapy (IORT) during surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Giving a drug before surgery allows doctors to study its effects. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is approved to treat certain types of breast cancer. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">The radiation treatment, called intraoperative radiation therapy (IORT), delivers a high dose of radiation to the area where the tumor was removed.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02977468' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.ascopost.com/News/20659' target='_blank'>ASCO Post: Keytruda</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/radiation/types/intraoperative' target='_blank'>Breastcancer.org: Intraoperative Radiation Therapy (IORT)</a> </li></ul>
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509

NEAREST SITE: 2569 miles
Columbia University Medical Center
New York,NY

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03069742

Web-based Decision Aids for High-Risk Women

Web-based Decision Aids for Breast Cancer Risk Assessment and Increasing Breast Cancer Chemoprevention in the Primary Care Setting: Randomized Controlled Trial Scientific Title

Purpose
To evaluate how well the RealRisks decision aid helps you to understand your breast cancer risk and your risk reduction options as well as develop an action plan with your provider.
Who is this for?
Women who are at high risk for breast cancer and receiving primary care at Columbia University Medical Center/ New York-Presbyterian Hospital.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RealRisks web-based decision aid tool</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard health education brochures</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RealRisks is a web-based decision aid for patients that is designed to work with the Breast Cancer Risk Navigation tool developed for doctors.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03069742' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://realrisks.dbmi.columbia.edu/' target='_blank'>RealRisks Website</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.facingourrisk.org/understanding-brca-and-hboc/information/risk-management/chemoprevention-breast-cancer/basics/overview.php' target='_blank'>Chemoprevention</a> </li></ul>
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510

NEAREST SITE: 2569 miles
Columbia University Medical Center
New York,NY

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT03165487

Breast Tissue Study in Women 40 and Older Having a Lumpectomy

Differential Comparison of the Breast Tumor Microenvironment Between Luminal A and Triple Negative Breast Cancer With and Without Radiation Treatment Scientific Title

Purpose
To study the healthy tissue surrounding your tumor to determine if this tissue affects how your cancer cells behave.
Who is this for?
Women with DCIS or stage I or stage II, HER2 negative (HER2-) breast cancer. You must also be 40 or older, have had a mammogram within the past six months, and be receiving treatment at the Breast Surgery and Radiation Oncology Clinics of Columbia University.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> <i class="seamTextEmphasis">During surgery</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 tissue and blood samples will be collected</li> <li class="seamTextUnorderedListItem">Samples will be collected before and after you receive intraoperative radiotherapy</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03165487' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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511

NEAREST SITE: 2569 miles
Columbia University Medical Center
New York,NY

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT03216421

Radiation Therapy During Surgery for DCIS

Locoregional Breast Cancer Recurrence Following Targeted Intraoperative Radiotherapy (IORT) for Ductal Carcinoma in Situ (DCIS) Scientific Title

Purpose
To study the safety and effects of using intraoperative radiation therapy (IORT) in women who are having a lumpectomy to treat DCIS.
Who is this for?
Women with DCIS who are scheduled to have a lumpectomy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT) during surgery</li> <li class="seamTextUnorderedListItem">Quality of life questionnaires, before and after IORT</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">IORT delivers a high dose of radiation during surgery to the area in the breast where the DCIS was removed.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03216421' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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512

NEAREST SITE: 2569 miles
Icahn School of Medicine at Mount Sinai
New York,NY

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03709446

Leflunomide in Previously Treated Metastatic Triple Negative & ER-Low Breast Cancer

A Phase I/II Trial of Leflunomide in Women With Previously Treated Metastatic Triple Negative Cancers Scientific Title

Purpose
To determine the safety and effects (good and bad) of leflunomide (Arava®), an oral drug that blocks dihydroorotate dehydrogenase (DHODH).
Who is this for?
Women with metastatic (stage IV) triple negative (ER-,PR-,HER2-) or ER-Low (1%-10% ER) breast cancer who have had no more than 2 chemotherapy drugs used to treat metastases.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Leflunomide (Arava®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling women with triple negative as well as ER-Low breast cancer.</li> <li class="seamTextUnorderedListItem">Leflunomide (Arava®) is approved to treat certain adults with rheumatoid arthritis.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03709446' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/leflunomide-oral-route/description/drg-20067158' target='_blank'>Mayo Clinic: Drugs and Supplements Leflunomide (Oral Route)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedaily.com/releases/2017/12/171219092956.htm' target='_blank'>Science Daily:Arthritis drug could help treat advanced skin cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncologynurseadvisor.com/home/cancer-types/breast-cancer/immunosuppressor-inhibits-metabolic-pathway-in-breast-cancer-kills-cancer-cells/' target='_blank'>Oncology Nurse Advisor: Immunosuppressor Inhibits Metabolic Pathway in Breast Cancer, Kills Cancer Cells</a> </li></ul>
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513

NEAREST SITE: 2569 miles
Icahn School of Medicine at Mount Sinai
New York,NY

VISITS: At least 1 visit every 3 weeks

PHASE: I-II

NCT ID: NCT03789097

Immunotherapy Vaccine, Radiation and Pembrolizumab for Metastatic Breast Cancer

In Situ Vaccination With Flt3L, Radiation, and Poly-ICLC Combined With Pembrolizumab in Patients With Non-Hodgkin's Lymphoma, Metastatic Breast Cancer, and Head and Neck Squamous Cell Carcinoma Scientific Title

Purpose
To test the safety and effects (good and bad) of an experimental immunotherapy injected into metastases when combined with radiation and pembrolizumab (Keytruda®).
Who is this for?
People with metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, once every 3 weeks</li> <li class="seamTextUnorderedListItem">Flt3L(CDX-301), by injection</li> <li class="seamTextUnorderedListItem">Radiation, 2 small treatments, on day 1 and day 2</li> <li class="seamTextUnorderedListItem">Poly ICLC (Hiltonol), by injection </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapies injected into the metastases are flt3L and poly-ICLC. </li> <li class="seamTextUnorderedListItem">Flt3L is an immune cell growth factor. It gets the body to make more immune cells. </li> <li class="seamTextUnorderedListItem">Poly-ICLC is an immune cell activating factor. It turns on the immune cells that have been brought to the tumor by flt3L. </li> <li class="seamTextUnorderedListItem">Radiation therapy will be targeted at the same metastases as these immunotherapies.</li> <li class="seamTextUnorderedListItem">Keytruda is a type of immunotherapy called a PD-1 inhibitor that is given intravenously (IV). It stimulates the body's immune system to go after cancer cells. It is approved to treat more than 10 types of cancer. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03789097' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.celldex.com/pipeline/cdx-301.php' target='_blank'>Drug company information page: CDX-301</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/poly-iclc' target='_blank'>NCI Drug Dictionary: poly ICLC</a> </li></ul>
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514

NEAREST SITE: 2570 miles
Ashikari Breast Center
Dobbs Ferry,NY

VISITS: Coincides with surgery and radiation therapy

PHASE: NA

NCT ID: NCT01792726

Radiation Therapy Boost During or After Lumpectomy For Stage I-III Breast Cancer Considered High Risk For Local Recurrence

An International Randomised Controlled Trial to Compare Targeted Intra-operative Radiotherapy Boost With Conventional External Beam Radiotherapy Boost After Lumpectomy for Breast Cancer in Women With a High Risk of Local Recurrence. Scientific Title

Purpose
To compare the anti-cancer activity of giving a radiation therapy boost during surgery (TARGIT) to the standard of care which is to give the radiation boost after surgery (EBRT).
Who is this for?
Women with stage I, stage II, or stage III breast cancer who are planning to have a lumpectomy (breast conserving surgery) and who are considered high risk for a local recurrence.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Targeted Radiotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Targeted intraoperative radiotherapy boost to the tumor bed, during surgery</li> <li class="seamTextUnorderedListItem">Standard of care whole-breast radiation therapy, after surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard Radiotherapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">External beam radiotherapy boost to the tumor bed, after surgery</li> <li class="seamTextUnorderedListItem">Standard of care whole-breast radiation therapy, after surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Targeted intraoperative radiotherapy (TARGIT) is given during surgery immediately after the tumor has been removed.</li> <li class="seamTextUnorderedListItem">This allows the radiation to directly target the tissue bed--the area where the tumor was located--where the risk of recurrence is highest.</li> <li class="seamTextUnorderedListItem">External beam radiation therapy (EBRT) is given after surgery and is the standard radiation therapy used following a lumpectomy.</li> <li class="seamTextUnorderedListItem">You will also receive whole-breast radiation therapy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01792726' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Targeted_intra-operative_radiotherapy' target='_blank'>Wikipedia: TARGIT</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation/types/internal' target='_blank'>Breastcancer.org: Internal Radiation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation/types/ext' target='_blank'>Breastcancer.org: External Whole-Breast Radiation</a> </li></ul>
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515

NEAREST SITE: 2574 miles
Montefiore Medical Center
Bronx,NY

VISITS: Visits weekly, ongoing

PHASE: I

NCT ID: NCT02824575

Rebastinib plus Chemotherapy for Metastatic Breast Cancer

Phase Ib Study of Rebastinib Plus Antitubulin Therapy With Paclitaxel or Eribulin in Patients With Metastatic Breast Cancer Scientific Title

Purpose
To look at how well Rebastinib works when it is given along with a chemotherapy drug.
Who is this for?
Women who metastatic (stage IV) HER2 negative breast cancer who have already received chemotherapy. If your tumor is estrogen receptor positive, you must have already taken an anti-estrogen drug.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rebastinib, by mouth, daily</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rebastinib, by mouth, daily</li> <li class="seamTextUnorderedListItem">Eribulin (Halaven®), by IV, weekly</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rebastinib is a new drug that is available only in clinical trials. Rebastinib is a targeted drug. </li> <li class="seamTextUnorderedListItem">The chemotherapy drugs being used in this study are paclitaxel (Taxol®) and eribulin (Halaven®). </li> <li class="seamTextUnorderedListItem">Both are used to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">The researchers will look at what treatments you have already had to decide whether you should get Taxol or Halaven.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02824575' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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516

NEAREST SITE: 2604 miles
Stony Brook University Cancer Center
Stony Brook,NY

VISITS: Visits monthly

PHASE: II

NCT ID: NCT02613416

Effect of Xgeva on Breast Tissue in Women Treated for DCIS, Stage I-III Breast Cancer

Phase II Correlative Study of Denosumab Effects on Tissue and Imaging Breast Biomarkers Scientific Title

Purpose
To investigate the effects (good and bad) that Xgeva has on breast tissue.
Who is this for?
Women who have completed treatment, including hormone therapy, for DCIS or stage I, stage II or stage III breast cancer. You must be at least 3 months post-treatment.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Observational period for 3 months</li> <li class="seamTextUnorderedListItem">followed by Denosumab (Xgeva®), by injection, monthly for 6 month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers are studying the relationship between breast density and breast cancer. </li> <li class="seamTextUnorderedListItem">Laboratory studies suggest a protein called the RANK ligand may be linked to breast density. </li> <li class="seamTextUnorderedListItem">Denosumab (Xgeva®) is an anti-RANK antibody that inhibits the RANK protein. </li> <li class="seamTextUnorderedListItem">In patients with bone metastases, Xgeva is used to prevent fractures, spinal cord compression, or the need for bone radiation or surgery.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02613416' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02613416?term=NCT02613416&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Denosumab' target='_blank'>Wikipedia: Denosumab</a> </li></ul>
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517

NEAREST SITE: 2614 miles
Yale School of Medicine
New Haven,CT

VISITS: Hospital stay for at least 3 weeks

PHASE: II

NCT ID: NCT04111510

T-Cell Immunotherapy for Metastatic Triple Negative Breast Cancer

A Phase 2 Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients With Pretreated Metastatic Triple Negative Breast Cancer Scientific Title

Purpose
To study the anti-cancer activity and effects (good and bad) of the personalized T-cell immunotherapy LN-145.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have received at least one but no more than three lines of chemotherapy for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy of your tumor to collect the white blood cells needed to make LN-145, (about 3 weeks before treatment)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">During hospital stay</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nonmyeloablative lymphodepletion (chemotherapy), daily, for 1 week</li> <li class="seamTextUnorderedListItem">LN-145, by infusion, once</li> <li class="seamTextUnorderedListItem">Interleukin-2 (IL-2), by IV, up to 6 times</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T lymphocytes are a natural part of your immune system and a T lymphocyte that has entered a cancer cell is called a Tumor Infiltrating Lymphocyte (TIL). </li> <li class="seamTextUnorderedListItem">From the biopsy of your tumor, researchers will remove TILs, and then in a laboratory make copies. </li> <li class="seamTextUnorderedListItem">The copies (LN-145) will be infused into your body during your hospital stay. </li> <li class="seamTextUnorderedListItem">After the infusion of LN-145, you will receive up to 6 doses of interleukin 2 (IL-2) to help the immune system.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04111510' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-tumor-infiltrating-lymphocytes-ln-145' target='_blank'>NCI Drug Dictionary: LN-145 (Autologous Tumor Infiltrating Lymphocytes LN-145)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/adoptive-cellular-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Adoptive Cell Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medicine.yale.edu/ycci/trial/6876/' target='_blank'>Yale University: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.iovance.com/clinical/our-clinical-program/' target='_blank'>Immunotherapy Company Information Page: How Adoptive Cell Therapy Works</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/t-cell-transfer-therapy' target='_blank'>NCI Cancer Treatment: T-Cell Transfer Therapy</a> </li></ul>
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518

NEAREST SITE: 2619 miles
Dartmouth-Hitchcock Medical Center
Lebanon,NH

VISITS: Daily visits for 5-10 days

PHASE: NA

NCT ID: NCT01089374

Partial Breast Radiation for Phyllodes Tumor

A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Scientific Title

Purpose
To determine what the chances are that a phyllodes tumor will recur in the breast when the breast is treated with partial breast radiation therapy after a lumpectomy.
Who is this for?
Women with phyllodes tumor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Partial breast irradiation (PBI) twice daily on 5 days over a period of 5-10 days </li> </ul> <p class="seamTextPara"> Treatment must start within 12 weeks of having surgery.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Phyllodes tumors are a very rare type of breast tumor. They tend to be large and to grow very quickly. </li> <li class="seamTextUnorderedListItem">When patients with phyllodes tumors who have been treated with a lumpectomy experience a recurrence, it is almost always at the original tumor site. </li> <li class="seamTextUnorderedListItem">This is why researchers believe partial breast radiation is likely to be as effective as whole breast radiation for treating malignant phyllodes tumors.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01089374' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.dartmouth.edu/breast/phyllodes_partial_radiation.shtml' target='_blank'>Norris Cotton Cancer Center: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://en.wikipedia.org/wiki/Phyllodes_tumor' target='_blank'>Wikipedia: Phyllodes Tumors</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/healthy/findcancerearly/womenshealth/non-cancerousbreastconditions/non-cancerous-breast-conditions-phyllodes-tumors' target='_blank'>Cancer.org: Phyllodes Tumors</a> </li></ul>
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519

NEAREST SITE: 2691 miles
Massachusetts General Hospital
Boston,MA

VISITS: Coincides with standard follow-up care

PHASE: NA

NCT ID: NCT01521741

Impact of Lymphedema on Quality of Life after Breast Cancer

Prospective Analysis of Symptoms, Functionality and Quality of Life Questionnaires to Evaluate Lymphedema in Patients Following Treatment for Breast Cancer. Scientific Title

Purpose
To determine how the symptoms and functional disability that accompany lymphedema can impact breast cancer survivors' quality of life.
Who is this for?
Women with breast cancer and without brain metastasis or axillary lymph node malignancy    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will complete the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires and arm measurements</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer treatments can result in long-term, painful swelling of the arm and hand, a condition called lymphedema. </li> <li class="seamTextUnorderedListItem">To be eligible, participants must be planning to have surgery and receive follow-up care for breast cancer at Massachusetts General Hospital.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01521741' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/search.jsp?terms=lymphedema' target='_blank'>BreastCancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/pdq/supportivecare/lymphedema/Patient/page1' target='_blank'>NCI: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/Treatment/TreatmentsandSideEffects/PhysicalSideEffects/Lymphedema/WhatEveryWomanwithBreastCancerShouldKnow/lymphedema-what-every-woman-with-breast-cancer-should-know-toc' target='_blank'>ACS: Lymphedema</a> </li></ul>
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520

NEAREST SITE: 2693 miles
Dana-Farber Cancer Institute
Boston,MA

VISITS: At least 8 visits over 6 months plus surgery

PHASE: II

NCT ID: NCT02623972

Eribulin and AC Before Surgery for HER2-Negative Inflammatory Breast Cancer

A Phase 2 Study of Eribulin Followed by Doxorubicin and Cyclophosphamide as Preoperative Therapy for HER2-negative Inflammatory Breast Cancer Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of treating HER2-negative inflammatory breast cancer with Halaven and AC before surgery.
Who is this for?
People with stage IIIb or IIIc HER2 negative inflammatory breast cancer. You must not have had surgery for your cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eribulin (Halaven®) by IV, for 4 cycles</li> <li class="seamTextUnorderedListItem">followed by AC by IV, for 4 cycles</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by surgery</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eribulin (Halaven®) is a chemotherapy drug used to treat advanced breast cancer. </li> <li class="seamTextUnorderedListItem">AC (Adriamycin® and Cytoxan®) is used to treat inflammatory breast cancer before surgery. </li> <li class="seamTextUnorderedListItem">Adding Halaven to the AC treatment may be more effective than using AC alone.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02623972' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02623972' target='_blank'>ClinicalTrials.gov trial info</a> </li></ul>
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521

NEAREST SITE: 2693 miles
Beth Israel Deaconess Medical Center
Boston,MA

VISITS: Number of visits unavailable, over 1 year

PHASE: NA

NCT ID: NCT02666378

Detecting Treatment-Related Cardiotoxicity in HER2 Positive Breast Cancer

Imaging Markers of Subclinical Cardiotoxicity in Breast Cancer Scientific Title

Purpose
To determine whether Cardiac Magnetic Resonance Imaging (CMR) and Echocardiogram (ECHO) tests can be used to identify early signs of heart problems that can be caused by Doxil and Herceptin.
Who is this for?
Women with HER2 positive breast cancer who are going to be treated with doxorubicin (Doxil®) and trastuzumab (Herceptin®) after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will undergo the following before treatment with chemotherapy and at predetermined times during and after treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI (Cardiac Magnetic Resonance Imaging, CMR)</li> <li class="seamTextUnorderedListItem">Ultrasound (Echocardiogram, ECHO)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is investigating whether Cardiac Magnetic Resonance Imaging (CMR) and Echocardiogram (ECHO) tests can be used to identify early signs of heart problems that can be caused by Doxil and Herceptin.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02666378' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20111005' target='_blank'>Breastcancer.org: Herceptin Related Heart Damage</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/heart-meds-reduce-herceptin-cardiac-damage' target='_blank'>Breastcancer.org: Medicine for Herceptin Related Heart Damage</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/tx-w-herceptin-needs-heart-monitoring' target='_blank'>Breastcancer.org: Women Treated With Herceptin Need Heart Monitoring</a> </li></ul>
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522

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: 3 visits

PHASE: NA

NCT ID: NCT02823262

Decision Aid for Women Age 70 and Older Diagnosed with ER+, HER2- Stage I-II Breast Cancer

A Breast Cancer Treatment Decision Aid for Women Aged 70 and Older Scientific Title

Purpose
To evaluate a breast cancer treatment Decision Aid created specifically for newly diagnosed older women.
Who is this for?
Women 70 or older who have been diagnosed with estrogen receptor positive (ER+), HER2 negative breast cancer. Your tumor must be either stage I or stage II.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Decision Aid</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Initial surgical consultation</li> <li class="seamTextUnorderedListItem">Treatment decision assistance provided by the Decision Aid</li> <li class="seamTextUnorderedListItem">Assessments, at 1 week and 5 months after surgical consultation</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Initial surgical consultation</li> <li class="seamTextUnorderedListItem">Usual care assistance when making treatment decisions</li> <li class="seamTextUnorderedListItem">Assessments, at 1 week and 5 months after surgical consultation</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">There are two phases to this study. </li> <li class="seamTextUnorderedListItem">In phase I, the researchers will collect feedback about the Decision Aid from breast cancer patients age 70 and over who were treated at least six months ago and their family members and clinicians. </li> <li class="seamTextUnorderedListItem">The researchers will use this feedback to improve the Decision Aid. </li> <li class="seamTextUnorderedListItem">In Phase II, the researchers will see if the revised Decision Aid helps women age 70 and older who have been diagnosed with breast cancer make treatment decisions.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02823262' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02823262?term=NCT02823262&rank=1' target='_blank'>The Decision Aid</a> </li></ul>
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523

NEAREST SITE: 2693 miles
Dana-Farber Cancer Institute
Boston,MA

VISITS: Weekly visits for 14-15 weeks

PHASE: I

NCT ID: NCT02999477

Keytruda plus Abraxane Before Surgery for Stage II-III Hormone Positive, HER2 Negative Breast Cancer

A Pilot Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer Scientific Title

Purpose
To investigate the safety and effects (good and bad) of different combinations of pembrolizumab (Keytruda®) and nab-paclitaxel (Abraxane®) when they are given before surgery.
Who is this for?
People with stage II or stage III hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who have not yet had surgery    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and will receive the following before surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Treatment will be given for 15 weeks, followed by surgery</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®) alone, by IV, weekly for 2 weeks</li> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Treatment will be given for 14 weeks, followed by surgery</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) alone, by IV, weekly for 2 weeks</li> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®), by IV, weekly</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is an immunotherapy drug. It gets the body's immune system to go after cancer cells by blocking a protein called programmed cell death (PD-1).</li> <li class="seamTextUnorderedListItem">Pembrolizumab is currently approved to treat certain types of melanoma, head and neck cancer, lung cancer, Hodgkin lymphoma, and other cancers.</li> <li class="seamTextUnorderedListItem">Nab-paclitaxel (Abraxane®) is a chemotherapy drug approved to treat metastatic breast cancer in patients who have already tried other cancer treatments.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02999477' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://externalmediasite.partners.org/Mediasite/Play/10e45413748143659e23155f9e13de881d' target='_blank'>Dana-Farber Cancer Institute: Patient-friendly informational video about this trial</a> </li></ul>
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524

NEAREST SITE: 2693 miles
Brigham and Women's Hospital
Boston,MA

VISITS: 1-10 visits over 1-2 weeks

PHASE: III

NCT ID: NCT03075072

How Different Radiation Therapy Techniques for People With 5 to 15 Brain Metastases Affect Their Quality of Life

Whole Brain Radiation Versus Stereotactic Radiation (SRS) in Patients With 5-15 Brain Metastases: A Phase III, Randomized Clinical Trial Scientific Title

Purpose
To compare the side effects and quality of life in people who receive stereotactic radiation to those who receive whole brain radiation (the current standard of care).
Who is this for?
People with metastatic (stage IV) breast cancer who have 5 to 15 brain metastases.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Whole brain radiation treatments, 10 times</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation treatments, 1-5 times</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation delivers focused radiation to each site of brain metastasis. </li> <li class="seamTextUnorderedListItem">Whole brain radiation treats the entire brain.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03075072' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.brainmetsbc.org/en/content/current-treatments-brain-metastases' target='_blank'>BrainMetsBC: Whole Brain Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.dana-farber.org/Adult-Care/Treatment-and-Support/Treatment-Centers-and-Clinical-Services/Center-for-Neuro-Oncology/Brain-Metastases-Program.aspx' target='_blank'>Dana-Farber Cancer Institute: Radiation Treatments</a> </li></ul>
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525

NEAREST SITE: 2693 miles
Dana-Farber Cancer Institute
Boston,MA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03130439

Abemaciclib in Advanced Triple Negative Breast Cancer That Tests Positive for Rb Protein

A Phase 2 Study of Abemaciclib for Patients With Retinoblastoma-Positive, Triple Negative Metastatic Breast Cancer Scientific Title

Purpose
To evaluate the safety, anti-cancer activity, and effects (good and bad) of abemaciclib (Verzenio®) in tumors that test positive for the Rb protein.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer. You tumor must test positive for the retinoblastoma (Rb) protein. The researchers will test your tumor for this protein.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®) is a CDK 4/6 inhibitor approved for use in metastatic hormone positive breast cancer. Its use in this trial is considered experimental. </li> <li class="seamTextUnorderedListItem">Studies have found that the Rb protein, which can help stop tumors from growing, doesn't work properly in certain cancers.</li> <li class="seamTextUnorderedListItem">Targets or mutations: Rb</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03130439' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.targetedonc.com/conference/asco-2014/Cell-Cycle-Inhibitor-Slows-Metastatic-Breast-Cancer' target='_blank'>Targeted Oncology: Abemaciclib</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://externalmediasite.partners.org/Mediasite/Play/f901a457a7924768b215636596e569f41d' target='_blank'>Dana-Farber Cancer Institute: Patient-friendly informational video about this trial</a> </li></ul>
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526

NEAREST SITE: 2693 miles
Dana-Farber Cancer Institute
Boston,MA

VISITS: At least 1 visit per month, ongoing

PHASE: I

NCT ID: NCT03294694

Ribociclib and Immunotherapy to Treat Metastatic Breast Cancer

A Phase 1 Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Combination With the PD-1 Inhibitor PDR001 in Patients With Metastatic Hormone Receptor-positive Breast Cancer and Metastatic Ovarian Cancer Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using ribociclib (Kisqali®) along with an immunotherapy or an immunotherapy and a hormone therapy.
Who is this for?
People with metastatic (stage IV) breast cancer that is hormone receptor positive and HER2-negative.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to one of the following groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ribociclib (Kisqali®), by mouth, daily for 3 weeks per month</li> <li class="seamTextUnorderedListItem">Spartalizumab (PDR001), by IV, once a month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ribociclib (Kisqali®), by mouth, daily for 3 weeks per month</li> <li class="seamTextUnorderedListItem">Spartalizumab (PDR001), by IV, once a month</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, 2 doses the first month, then once monthly</li> </ul> <p class="seamTextPara"> Additional procedures: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 biopsies (before treatment and at 7 weeks)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Kisqali is a type of targeted therapy called a CDK 4/6 inhibitor. It is approved for use along with an anti-estrogen therapy to treat HR-positive HER2-negative metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">The aromatase inhibitor being used in this study is fulvestrant (Faslodex®). </li> <li class="seamTextUnorderedListItem">The immunotherapy being used in this study is spartalizumab (PDR001). It is a type of immunotherapy that targets PD-1. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with metastatic ovarian cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03294694' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ribociclib' target='_blank'>NCI Dictionary: Ribociclib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/spartalizumab' target='_blank'>NCI Dictionary: Spartalizumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fulvestrant' target='_blank'>NCI Dictionary: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2018/ribociclib-fda-expanded-approval-breast-cancer?cid=eb_govdel' target='_blank'>NCI News: Ribociclib Approval Expanded for Some Women with Advanced Breast Cancer</a> </li></ul>
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527

NEAREST SITE: 2693 miles
Dana-Farber Cancer Institute
Boston,MA

VISITS: Visits every 1.5 months for 6 months, then ever 3 months thereafter

PHASE: II

NCT ID: NCT03344965

Olaparib for Metastatic Breast Cancer with Certain Tumor Mutations

A Phase 2 Study of Olaparib Monotherapy in Metastatic Breast Cancer Patients With Germline or Somatic Mutations in DNA Repair Genes (Olaparib Expanded) Scientific Title

Purpose
To investigate the safety and effects (good and bad) of using olaparib (Lynparza®) has a DNA repair gene mutation, such as BRCA1 or BRCA2.
Who is this for?
People with metastatic (stage IV) breast cancer that has inherited mutations. You may not have progressed on more than two chemotherapy regimens in the metastatic setting    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, daily, ongoing </li> <li class="seamTextUnorderedListItem">Tumor measurements, every 1.5 months for 6 months, then every 3 months thereafter</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of targeted therapy known as a PARP inhibitor. </li> <li class="seamTextUnorderedListItem">PARP helps repair DNA when it becomes damaged. Studies showed that the tumors in individuals who have inherited or acquired a mutation in the BRCA 1 or BRCA 2 genes are often sensitive to killing by PARP inhibitors.</li> <li class="seamTextUnorderedListItem">Olaparib is approved to treat recurrent ovarian cancer. </li> <li class="seamTextUnorderedListItem">Patients with inherited BRCA1/2 mutations are NOT eligible for this study</li> <li class="seamTextUnorderedListItem">Targets or mutations: somatic (tumor) BRCA1/2 mutation, ATM, ATR, BARD1, BRIP1 (FANCJ), CHEK2 , FANCA, FANCC, FANCD2, FANCE, FANCF, FANCM, MRE11A, NBN, PALB2, RAD50, RAD51C, RAD51D, and other HR-related genes.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03344965' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lynparza.com' target='_blank'>AstraZeneca Drug Information Page: Olaparib</a> </li></ul>
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528

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: Weekly visits for 5 weeks, then every 3 weeks, ongoing

PHASE: I

NCT ID: NCT03362060

PVX-410 Vaccine & Pembrolizumab for Advanced Triple Negative Breast Cancer That Tests Positive for HLA-A2+

A Phase 1b Study of Safety and Immune Response to PVX-410 Vaccine Alone and in Combination With Pembrolizumab in HLA-A2+ Patients With Metastatic Triple Negative Breast Cancer (TNBC) Scientific Title

Purpose
To study the anti-cancer activity of using the experimental vaccine PVX-410 in combination with the PD-1 inhibitor pembrolizumab (Keytruda®).
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that tests positive for the protein HLA-A2. The researchers will test your tumor for this protein.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVX-410 vaccine, by IV, weekly for 5 weeks </li> <li class="seamTextUnorderedListItem">Followed by 2 booster vaccines 5 weeks after receiving the first vaccine, every 4 months </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVX-410 is an experimental vaccine that may help the immune system find and attack cancer cells. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy drug called a PD-1 inhibitor that has been approved to treat some cancer types, including breast cancer. It gets the immune system to go after cancer cells by blocking a protein called programmed cell death (PD-1).</li> <li class="seamTextUnorderedListItem">Targets or mutations: HLA-A2</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03362060' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/whats-new-in-immunotherapy-research.html' target='_blank'>Cancer.org: What's New in Cancer Immunotherapy Research?</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncopep.com' target='_blank'>Drug Company Information Page: PVX-410</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda</a> </li></ul>
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529

NEAREST SITE: 2693 miles
Dana-Farber Cancer Institute
Boston,MA

VISITS: Visits every 3 week, ongoing

PHASE: II

NCT ID: NCT03483012

Immunotherapy and Radiation Therapy for Women With Triple Negative Breast Cancer That Has Spread to the Brain

A Phase II Study of Atezolizumab in Combination With Stereotactic Radiosurgery for Patients With Triple-negative Breast Cancer and Brain Metastasis Scientific Title

Purpose
To study the safety and anti-cancer activity of combining stereotactic radiosurgery (radiation therapy) and the immunotherapy drug atezolizumab (Tecentriq®).
Who is this for?
Women with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that has spread to the brain.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atezolizumab (Tecentriq®), by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery, within 2 weeks after brain MRI</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain MRI</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery delivers focused radiation to each individual brain metastasis. It is routinely used to treat brain metastases. </li> <li class="seamTextUnorderedListItem">The immunotherapy drug being used in this study is atezolizumab (Tecentriq®). It gets the immune system to go after cancer cells by blocking a protein called PD-L1 (programmed death ligand-1). It is approved to treat certain types of bladder cancer and lung cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03483012' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/types/recur_metast/treat_metast/options/local/brain/radiosurgery' target='_blank'>Breastcancer.org: Stereotactic Radiosurgery for Brain Mets</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/patients/medicines/tecentriq' target='_blank'>Genentech Information Page: Tecentriq</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.brainmetsbc.org' target='_blank'>BrainMetsBC.org</a> </li></ul>
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530

NEAREST SITE: 2693 miles
Massachusetts General Hospital
Boston,MA

VISITS: Number of visits unavailable, before surgery

PHASE: I

NCT ID: NCT03596073

Topical Ointment Calcipotriene Before Surgery to Stimulate Immune Cells

A Pilot Trial of Topical Calcipotriene Treatment for Breast Cancer Immunoprevention Scientific Title

Purpose
To see the effect that a topical ointment called calcipotriene has on the tumor's microenvironment.
Who is this for?
People who are 45 or older, scheduled to have breast cancer surgery, and not receiving chemotherapy before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Topical calcipotriene ointment, 2 times per day, for the period between biopsy and surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Topical vaseline, 2 times per day, for the period between core biopsy and surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Calcipotriene is a man-made form of vitamin D.</li> <li class="seamTextUnorderedListItem">It is approved by the FDA to treat psoriasis. Its use in breast cancer is experimental. </li> <li class="seamTextUnorderedListItem">Giving the treatment before surgery allows researchers to look at how it affects the tumor's microenvironment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03596073' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-1506/calcipotriene-topical/details' target='_blank'>WebMD: Calcipotriene</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/1672178' target='_blank'>Pubmed: Topical calcipotriol treatment in advanced breast cancer</a> </li></ul>
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531

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03641755

Olaparib & Sapacitabine for People with Advanced Breast Cancer & an Inherited BRCA1/2 Mutation

A Phase Ib/II Study of Olaparib With Sapacitabine in BRCA Mutant Breast Cancer Scientific Title

Purpose
To look at the safety, effects (good and bad) and best dose of sapacitabine to use along with olaparib (Lynparza®).
Who is this for?
People with metastatic (stage IV) breast cancer who have been tested for and found to have an inherited BRCA1 or BRCA2 mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice daily</li> <li class="seamTextUnorderedListItem">Sapacitabine, by mouth, 2 weeks on 2 weeks off</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sapacitabine is an investigational chemotherapy taken orally (by mouth). </li> <li class="seamTextUnorderedListItem">Lynparza is a type of targeted therapy known as a PARP inhibitor. </li> <li class="seamTextUnorderedListItem">PARP inhibitors block poly (ADP-ribose) polymerase, an enzyme that plays a role in cancer cell growth. </li> <li class="seamTextUnorderedListItem">Lynparza is approved to treat HER2-negative metastatic breast cancer.</li> <li class="seamTextUnorderedListItem">Targets and mutations: inherited BRCA 1 and BRCA 2 mutations</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03641755' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sapacitabine' target='_blank'>NCI Drug Dictionary: Sapacitabine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cyclacel.com/research_programs_oncology_cyc682.shtml' target='_blank'>Cyclacel Pharmaceuticals Drug Information Page: Sapacitabine</a> </li></ul>
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532

NEAREST SITE: 2693 miles
Dana-Farber Cancer Institute
Boston,MA

VISITS: Visits every 3 weeks

PHASE: II

NCT ID: NCT03765983

GDC-0084 with Trastuzumab for HER2 Positive Breast Cancer with Brain Metastases

Phase II Trial of GDC-0084 in Combination With Trastuzumab for Patients With HER2-Positive Breast Cancer Brain Metastases Scientific Title

Purpose
To study the safety and effects (good and bad) of using the experimental PI3K inhibitor GDC-0084 in combination with trastuzumab (Herceptin®).
Who is this for?
People with metastatic (stage IV) breast cancer that has spread (metastasized) to the brain.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0084, by mouth, daily</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">GDC-0084 is an investigational drug that blocks a protein called PI3-kinase that helps cancer cells grow. </li> <li class="seamTextUnorderedListItem">Herceptin is a HER2 targeted therapy. It is routinely used to for HER2 positive (HER2+) breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03765983' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pi3k-inhibitor-gdc-0084' target='_blank'>NCI Drug Dictionary: GDC-0084</a> </li></ul>
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533

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute/Brigham and Women's Hospital
Boston,MA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03945721

Niraparib & Radiation in TNBC That Did Not Fully Respond to Neoadjuvant Chemotherapy

A Phase I Study of Niraparib Administered Concurrently With Postoperative RT in Patients With Triple Negative Breast Cancer and an Incomplete Pathologic Response Scientific Title

Purpose
To look at the safety and best dose of niraparib (Zejula®) when it is used along with radiation therapy.
Who is this for?
People with stage I, stage II or stage IIIA triple negative (ER-, PR- and HER2-) breast cancer that did not completely respond to the chemotherapy given before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Niraparib (Zejula®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Radiation therapy </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact the research site for the treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Zejula is a type of targeted therapy called a PARP inhibitor. These drugs kill cancer cells by preventing them from repairing damage to their DNA. </li> <li class="seamTextUnorderedListItem">Zejula is approved to treat ovarian cancer. Its use in breast cancer is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03945721' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fda.gov/drugs/resources-information-approved-drugs/niraparib-zejula' target='_blank'>FDA: Niraparib (Zejula®)</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/niraparib.aspx' target='_blank'>Chemocare: Niraparib (Zejula®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://cancerres.aacrjournals.org/content/79/4_Supplement/PD5-02' target='_blank'>Cancer Research Abstract: Durability of clinical benefit with niraparib + pembrolizumab in patients with advanced TNBC beyond BRCA</a> </li></ul>
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534

NEAREST SITE: 2693 miles
Massachusetts General Hospital Cancer Center
Boston,MA

VISITS: 2 visits in the first month, then once a month thereafter

PHASE: I

NCT ID: NCT03959891

Ipatasertib, Hormone Therapy and Ibrance for Metastatic Breast Cancer (TAKTIC)

Clinical Trial to Evaluate Safety and Anti-tumor Activity of AKT Inhibitor, Ipatasertib,With Endocrine Therapy With/Without CDK 4/6 Inhibitor for Patients With Metastatic Hormone Receptor Positive Breast Cancer (TAKTIC) Scientific Title

Purpose
To study the safety and effects (good and bad) of combining ipatasertib with palbociclib (Ibrance®) and/or a hormone therapy.
Who is this for?
Postmenopausal women with estrogen receptor positive, HER2 negative advanced (some stage III) or metastatic (stage IV) breast cancer that has progressed on at least one therapy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, twice a month for the first month, then once a month thereafter</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipatasertib is an investigational targeted therapy that blocks AKT (protein kinase B).</li> <li class="seamTextUnorderedListItem">Ibrance is a CDK4/6 inhibitor approved to treat HR positive, HER2 negative breast cancer in combination with an anti-estrogen therapy. </li> <li class="seamTextUnorderedListItem">The two hormone therapies used in this study are fulvestrant (Faslodex®) and letrozole (Femara®). Both are routinely used to treat breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03959891' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ipatasertib' target='_blank'>NCI Drug Dictionary: Ipatasertib</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/conference-coverage/asco-2018/data-support-phase-3-trial-with-akt-inhibitor-in-triple-negative-breast-cancer' target='_blank'>Oncolive: Early OS Data Support Phase III Trial With AKT Inhibitor Ipatasertib for TNBC</a> </li></ul>
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535

NEAREST SITE: 2693 miles
Massachusetts General Hospital Cancer Center
Boston,MA

VISITS: Weekly visits for 2 out of every 3 weeks

PHASE: I-II

NCT ID: NCT04039230

Sacituzumab Govitecan and Talazoparib for Women With Metastatic Triple Negative Breast Cancer

Phase 1b/2 Study to Evaluate Antibody-Drug Conjugate Sacituzumab Govitecan in Combination With PARP Inhibitor Talazoparib in Patients With Metastatic Breast Cancer Scientific Title

Purpose
To evaluate the safety, best dose, and effects (good and bad) of using a PARP inhibitor in combination with sacituzumab govitecan.
Who is this for?
Women with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Sacituzumab govitecan (IMMU-132), by IV, once a week, for 2 out of every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The PARP inhibitor being used in this study is talazoparib (Talzenna®). It is approved for use in individuals with advanced triple negative breast cancer and an inherited BRCA 1 or BRCA 2 mutation. </li> <li class="seamTextUnorderedListItem">Sacituzumab govitecan (IMMU-132) has been approved for use in some metastatic triple negative breast cancer. </li> <li class="seamTextUnorderedListItem">Sacituzumab govitecan is an antibody-drug conjugate (ADC). This type of drug uses an antibody that targets cancer cells to deliver a chemotherapy drug directly to these cells. </li> <li class="seamTextUnorderedListItem">The antibody in this drug targets TROP2 proteins. It delivers the chemotherapy drug SN-38.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04039230' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sacituzumab-govitecan' target='_blank'>NCI Drug Dictionary: Sacituzumab Govitecan</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ascopost.com/news/april-2020/fda-approves-sacituzumab-govitecan-hziy-for-patients-with-previously-treated-metastatic-triple-negative-breast-cancer/' target='_blank'>ASCO: FDA Approves Sacituzumab Govitecan-hziy for Patients With Previously Treated Metastatic Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.immunomedics.com/sacituzumab-govitecan-immu-132/' target='_blank'>Drug Company Information Page: Sacituzumab Govitecan</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.talzenna.com/?source=google&HBX_PK=s_talazoparib&skwid=43700039109819878' target='_blank'>Pfizer Oncology: Talzenna™</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/2019/05/01/mbc-news-11/' target='_blank'>Metastatic Trial Talk: ADCs in Breast Cancer</a> </li></ul>
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536

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: 1 visit per week

PHASE: II

NCT ID: NCT04468061

Sacituzumab Govitecan with or without Pembrolizumab for Advanced Triple Negative or ER-Low, HER2- Breast Cancer

Randomized Phase II Study of Sacituzumab Govitecan With or Without Pembrolizumab in PD-L1-negative Metastatic Triple Negative Breast Cancer (TNBC) Scientific Title

Purpose
To study the safety and anti-cancer activity of giving the antibody-drug conjugate sacituzumab govitecan (Trodelvy) alone and in combination with the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-. HER2-) or ER-Low (1%-10% ER), HER2 negative breast cancer that is PD-L1 negative, who have not yet started treatment for metastatic disease.    Full eligibility criteria
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  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sacituzumab Govitecan (Trodelvy), by IV, every week (2 weeks on, 1 week off), ongoing</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV, every 3 weeks, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sacituzumab Govitecan (Trodelvy), by IV, every week (2 weeks on, 1 week off), ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sacituzumab govitecan is an antibody-drug conjugate (ADC)--it uses an antibody that targets cancer cells to deliver a chemotherapy drug directly to these cells. </li> <li class="seamTextUnorderedListItem">The antibody in sacituzumab govitecan targets TROP2 proteins and delivers the chemotherapy Irinotecan. </li> <li class="seamTextUnorderedListItem">Sacituzumab govitecan is approved for use in people with metastatic triple negative breast cancer who have already received at least two other therapies for metastatic disease. </li> <li class="seamTextUnorderedListItem">Pembrolizumab is a type of immunotherapy called a PD-1 inhibitor. It is approved to treat certain types of cancers but its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER-Low. This trial is enrolling people with triple negative as well as ER-Low, HER2 negative breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04468061' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2020/fda-sacituzumab-govitecan-triple-negative-breast-cancer' target='_blank'>NCI Cancer Currents Blog: Sacituzumab Govitecan Approved for Metastatic Triple-Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.trodelvy.com/dosing' target='_blank'>Immunomedics Drug Information Page: Trodelvy (Sacituzumab Govitecan)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/pembrolizumab' target='_blank'>Cancer Research UK: Pembrolizumab (Keytruda)</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/lab-tests/pdl1-immunotherapy-tests/' target='_blank'>NIH MedlinePlus: PDL1 (Immunotherapy) Tests</a> </li></ul>
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537

NEAREST SITE: 2694 miles
Massachusetts General Hospital Cancer Center
Boston,MA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03990896

Talazoparib in Women With Metastatic Triple Negative or HR+, HER2- Breast Cancer with a Tumor (Not Inherited) BRCA1/2 Mutation

Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial Scientific Title

Purpose
To study the anti-cancer activity of the PARP inhibitor Talazoparib (Talzenna®) in breast cancer tumors that test positive for a tumor (not inherited) BRCA 1 or BRCA 2 mutation.
Who is this for?
Women with metastatic (stage IV) triple negative (ER-, PR-, HER2-) or hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer. Your tumor must test positive for a BRCA 1 or a BRCA 2 tumor (not inherited) mutation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®) is a type of targeted therapy called a PARP inhibitor. It prevents the PARP protein from repairing damaged DNA in tumor cells.</li> <li class="seamTextUnorderedListItem">BRCA1/2 mutations are called germline when they are inherited. </li> <li class="seamTextUnorderedListItem">BRCA1/2 mutations are called somatic when they are not inherited.</li> <li class="seamTextUnorderedListItem">Targets or mutations: BRCA 1 (tumor), BRCA 2 (tumor)</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03990896' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/somatic-mutation' target='_blank'>NCI Drug Dictionary: Somatic Mutation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.talzenna.com/?source=google&HBX_PK=s_talazoparib&skwid=43700039109817433' target='_blank'>Pfizer Oncology: Talzenna®</a> </li><li class='seamTextUnorderedListItem'><a href='https://blog.dana-farber.org/insight/2016/07/how-do-parp-inhibitors-work-in-cancer/' target='_blank'>Dana-Farber Cancer Institue: How Do PARP Inhibitors Work In Cancer? (Video)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/publications/oncology-live/2017/vol-18-no-13/blurring-the-lines-between-germline-and-somatic-mutations-in-cancer' target='_blank'>OncLive: Blurring the Lines Between Germline and Somatic Mutations in Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nature.com/articles/s41416-018-0127-5' target='_blank'>Journal Article: BRCA1/2 Testing: Therapeutic Implications for Breast Cancer Management</a> </li></ul>
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538

No Travel Required

VISITS: Saliva sample and questionnaires

PHASE: NA

NCT ID: NCT02253251

A Study of the Inherited KRAS-Variant Mutation and Breast Cancer Risk

Clinical Validation of the Role of microRNA Binding Site Mutations in Cancer Risk, Prevention and Treatment Scientific Title

Purpose
To analyze the association between the KRAS-variant mutation and cancer risk.
Who is this for?
People with stage I, stage II, stage III or metastatic (stage IV) breast cancer    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will provide a saliva sample and answer questionnaires periodically over 10 years. Participants will be able to get their KRAS-variant test results after submitting their sample, at a discounted cost ($295). </p> <p class="seamTextPara"> Click here for the <a href="http://mirakind.org/study-eligibility-questionnaire/">Eligibility Survey</a></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An inherited genetic mutation, a KRAS-variant, may increase a person's risk of developing breast or other types of cancer. </li> <li class="seamTextUnorderedListItem">This study will follow participants for 10 years. </li> <li class="seamTextUnorderedListItem">The researchers will also look at the effect that different lifestyle factors have on cancer risk. </li> <li class="seamTextUnorderedListItem">All participants will have a saliva sample tested for the KRAS-variant. </li> <li class="seamTextUnorderedListItem">To be eligible, participants must have a personal or family history of breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02253251' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://mirakind.org/wp-content/uploads/2014/03/Understanding_Results.pdf' target='_blank'>MiraKind.org: KRAS-Variant</a> </li><li class='seamTextUnorderedListItem'><a href='https://miradx.com/test/kras-variant/' target='_blank'>MiraDx: KRAS-Variant Testing</a> </li><li class='seamTextUnorderedListItem'><a href='http://mirakind.org/study-eligibility-questionnaire/' target='_blank'>MiraKind Eligibility Survey</a> </li></ul>
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539

No Travel Required

VISITS: Saliva sample and questionnaire by mail

PHASE: NA

NCT ID: NCT01251900

BRCA Gene Mutations in Latinas and Hispanic Women with Breast Cancer

BRCA1 and BRCA2 Mutations and Triple Negative Disease in Hispanic/Latino Breast Cancer Subjects Scientific Title

Purpose
To study how common BRCA1 and BRCA2 mutations are among Hispanic women and Latinas with breast cancer.
Who is this for?
Women with stage I, stage II, stage III or metastatic (stage IV) breast cancer who are Hispanic or Latina.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Provide a saliva sample </li> <li class="seamTextUnorderedListItem">Complete a questionnaire </li> <li class="seamTextUnorderedListItem">Provide a copy of pathology report</li> </ul> <p class="seamTextPara"> No study visits are required. The consent process can be done by phone (in English or Spanish) and the questionnaire and saliva collections completed by U.S. mail.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some women who have triple negative (ER-, PR-, HER2-) breast cancer also have a BRCA 1 or BRCA 2 genetic mutation.</li> <li class="seamTextUnorderedListItem">The number of Hispanic women and Latinas with triple negative breast cancer who also have a BRCA1/2 mutation is unknown. </li> <li class="seamTextUnorderedListItem">Learning more about BRCA1/2 mutation rates among Latinas and Hispanic women will help researchers provide better treatment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01251900' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA' target='_blank'>NCI: BRCA Mutations</a> </li><li class='seamTextUnorderedListItem'><a href='http://ww5.komen.org/BreastCancer/InheritedGeneticMutations.html' target='_blank'>Susan G. Komen: Gene Mutations</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/TripleNegativeBreastCancer.html' target='_blank'>Susan G. Komen: Triple Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/espanol/tipos/seno' target='_blank'>NCI: Cá¡ncer de seno</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/espanol/cancer/cancerdeseno/' target='_blank'>American Cancer Society: Cá¡ncer de seno</a> </li></ul>
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540

No Travel Required

VISITS: Weekly phone sessions, for 6 weeks

PHASE: II

NCT ID: NCT03998618

Telephone Support to Reduce Fatigue in Women With Metastatic Breast Cancer

Telephone Support for Metastatic Breast Cancer Patients Scientific Title

Purpose
To evaluate whether a telephone-based psychotherapy program can reduce fatigue and improve activity level, mood, and cognition.
Who is this for?
Women with metastatic (stage IV) breast cancer being treated at the Indiana University (IU) Simon Cancer Center, Eskenazi Health, IU Health North, IU Health Bloomington, IU Health Ball Memorial, Franciscan Health, or St. Vincent Health.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acceptance and Commitment Therapy: 50-minute phone sessions, weekly, for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education/Support: 50-minute phone sessions, weekly, for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Follow-up</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">30-minute phone assessments at 2 weeks, 3 months, and 6 months after study activities</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The type of psychotherapy being studied is called Acceptance and Commitment Therapy (ACT). </li> <li class="seamTextUnorderedListItem">It teaches mindfulness exercises as well as ways to identify and engage in activities consistent with your personal values.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03998618' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/29327085' target='_blank'>Pubmed Abstract: Acceptance and commitment therapy for symptom interference in metastatic breast cancer patients</a> </li></ul>
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541

No Travel Required

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT04160182

Online Program with an Occupational Therapist to Help Women Treated for DCIS, Stage I, Stage II, or Stage III Breast Cancer Manage Fatigue

Feasibility and Effectiveness of an Internet-based Intervention to Manage Fatigue in Breast Cancer Survivors Scientific Title

Purpose
To evaluate whether six weeks of online meetings with an occupational therapist who teaches fatigue management skills helps reduce fatigue or the effects of fatigue on quality of life.
Who is this for?
Women who were treated for DCIS, stage I, stage II, or stage III breast cancer who are currently not receiving chemotherapy or radiation, are experiencing fatigue, and are not taking medications for depression, sleep issues, or fatigue.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Online sessions with an occupational therapist, 45 minutes each, weekly, for 6 weeks</li> <li class="seamTextUnorderedListItem">A workbook containing information, strategies, and skills to help you manage your fatigue</li> <li class="seamTextUnorderedListItem">Help from the occupational therapist in applying these skills to your life</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fatigue is a common side effect of breast cancer treatment.</li> <li class="seamTextUnorderedListItem">This study will evaluate whether six weeks of online meetings with an occupational therapist who teaches fatigue management skills helps reduce fatigue or the effects of fatigue on quality of life.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04160182' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/fatigue' target='_blank'>Breastcancer.org: Fatigue</a> </li></ul>
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542

No Travel Required

VISITS: Online surveys

PHASE: NA

NCT ID: NCT02333604

CSC Online Survey: The Cancer Experience Registry

Cancer Experience Registry: An Online Initiative to Understand the Experiences of Those Impacted by a Cancer Diagnosis (CER) Scientific Title

Purpose
To learn more about the emotional and social experiences and needs of people affected by cancer.
Who is this for?
People diagnosed with DCIS, stage I, stage II, stage III, or metastatic (stage IV) breast cancer and people who provide care to individuals diagnosed with cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participation in this study involves the completion of an online questionnaire. The questionnaire may be accessed at the following link: </p> <a href="http://www.cancersupportcommunity.org/MainMenu/ResearchTraining/Cancer-Experience-Registry.html" target="_blank">www.cancerexperienceregistry.org</a>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The researchers hope to use this information to improve the educational materials and the overall quality of care that cancer patients receive. </li> <li class="seamTextUnorderedListItem">This study is also enrolling people diagnosed with other types of cancer. </li> <li class="seamTextUnorderedListItem">The data collected from this study can be found <a href="https://www.cancersupportcommunity.org/RegistryIndexReport2017" target="_blank">here.</a></li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02333604' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerexperienceregistry.org/' target='_blank'>Cancer Support Community Study Website: Cancer Experience Registry</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancersupportcommunity.org/RegistryIndexReport2017' target='_blank'>Cancer Support Community: Cancer Experience Registry Index Report 2017</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youtube.com/watch?v=SyyUYqyNaCc' target='_blank'>Cancer Support Community YouTube Channel: What is the Cancer Experience Registry?</a> </li></ul>
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543

No Travel Required

VISITS: Mobile or online surveys

PHASE: NA

NCT ID: NCT00000003

MBC Connect Patient Registry: Sharing MBC History, Experiences, and Quality of Life

MBC Connect -- Patient Powered. Research Driven Scientific Title

Purpose
To collect information about the experiences of people with metastatic breast cancer for researchers and clinicians and to provide personalized information to each participant.
Who is this for?
People with metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will be asked to fill out surveys about your breast cancer diagnosis, treatment history and quality of life.</li> <li class="seamTextUnorderedListItem">Based on information you enter, you will get personalized insights and alerts with MBC news, events, and clinical trial opportunities.</li> </ul> <p class="seamTextPara"> To join the registry, click here: <a href="https://www.mbcconnect.org/" target="_blank">www.mbcconnect.org/</a><p></p></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MBC Connect is a free, web and mobile-friendly registry that collects information about the experiences of people with metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Joining the registry allows you to receive personalized information about MBC-related news, events, and clinical trial opportunities. </li> <li class="seamTextUnorderedListItem">Researchers and clinicians will be able to analyze information collected in the registry in research studies. </li> <li class="seamTextUnorderedListItem">MBC Connect is available in English and Spanish.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'><a href='https://www.mbcconnect.org/' target='_blank'>MBC Connect</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mbcalliance.org/' target='_blank'>Metastatic Breast Cancer Alliance</a> </li></ul>
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544

No Travel Required

VISITS: Online forms, questionnaires, saliva sample by mail

PHASE: NA

NCT ID: NCT00000002

MBC Project: Collecting Information About Metastatic Breast Cancer To Further Research

The Metastatic Breast Cancer Project Scientific Title

Purpose
To accelerate research in treating, curing and preventing metastatic breast cancer.
Who is this for?
People with metastatic (stage IV) breast cancer.    Full eligibility criteria
Contact research site
Close

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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Your participation will include the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Complete a simple online form about yourself and your cancer</li> <li class="seamTextUnorderedListItem">Fill out an online consent form that gives your permission for the researchers to obtain copies of your medical records and some of your stored tumor tissue</li> <li class="seamTextUnorderedListItem">Provide a saliva sample and send back via U.S. mail </li> </ul> <p class="seamTextPara"> To learn more and/or to participate, click here: <a href="https://www.mbcproject.org/" target="_blank">https://www.mbcproject.org/</a><p></p></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The goal of the Metastatic Breast Cancer Project is to accelerate research in treating, curing and preventing metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">If you take part in the project, you will fill out questionnaires, provide a saliva sample, and share a piece of your stored tumor tissue and copies of your medical records with the researchers. </li> <li class="seamTextUnorderedListItem">The researchers believe analyzing this data will help them learn more about metastatic breast cancer and make more research advances. </li> <li class="seamTextUnorderedListItem">The MBC Project was created by a coalition of researchers and breast cancer advocacy organizations.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'><a href='https://www.mbcproject.org/' target='_blank'>The Metastatic Breast Cancer Project</a> </li></ul>
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