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Find Breast Cancer Clinical Trials That Are Right For You
The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.
Use the search box and filters to find a trial that’s right for you.
Currently viewing trials
(Last updated: July 11, 2025)
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Treatment
Brain Mets
BRCA1/2 (inherited)
Chemotherapy
Hormone Therapy
Leptomeningeal Disease
Radiation Oncology
Surgery
Surgery: Reconstruction
Targeted Therapy: All
Targeted Therapy: ADC
Targeted Therapy: Anti-HER2 Therapy
Targeted Therapy: CDK Inhibitors
Targeted Therapy: PARP Inhibitors
Targeted Therapy: Tumor Mutations
Targeted Therapy: Other Targeted Therapy
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AKT
ALK
AR
BARD1
BRCA1/2 (tumor)
BRIP1
CD205
CD70
CHEK2 or CHEK1
dMMR/MSI-H
ESR1
FGFR
HER2/ERBB2
HLA
MET or C-Met
NTRK
PALB2
PIK3CA or PI3K
PTEN
RAD51
RAF (including BRAF)
RAS (KRAS or NRAS)
RB
ROS1
TP53
1
NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA
VISITS: Coincides with surgery
PHASE: II
NCT ID: NCT05020574
Impact of Antibiotics on Infection and the Microbiome in People Receiving a Mastectomy
Microbiome and Association With Implant Infections: Investigating the Impact of Antibiotics on the Gut and Breast Microbiomes Post-mastectomy With Implant-based Breast Reconstruction Scientific Title
Purpose
To study the effects (good and bad) of antibiotics after mastectomy with immediate reconstruction on infection and the microbiome.
Who is this for?
Women with stage 0 (DCIS), stage I, stage II, or some stage III breast cancer or people at risk of breast cancer who are planning to receive a mastectomy with immediate reconstruction.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, before and during surgery</li> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, daily for at least 7 days after surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, before and during surgery</li> <li class="seamTextUnorderedListItem">No antibiotics after surgery (unless infection occurs)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A mastectomy is surgery to remove a breast.</li> <li class="seamTextUnorderedListItem">Women with a strong family history of breast cancer or a BRCA mutation may choose to undergo a mastectomy to reduce their risk of developing breast cancer.</li> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) is an antibiotic used to prevent infection after surgery.</li> <li class="seamTextUnorderedListItem">The microbiome consists of the many bacteria, viruses, and fungi found on your body.</li> <li class="seamTextUnorderedListItem">The harmful bacteria cause disease such as infection, and the beneficial bacteria help keep you healthy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05020574' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a682733.html' target='_blank'>MedlinePlus: Cephalexin (Keflex®)</a> </li></ul>
2
NEAREST SITE: 339 miles
Providence Saint John's Hospital
Santa Monica,CA
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT05289466
Intraoperative Radiotherapy During Partial Mastectomy for Women Ages 50+ with Recurrent DCIS or Stage I-III Breast Cancer
Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation Scientific Title
Purpose
To study the safety, effects (good and bad), and anti-cancer activity of intraoperative radiotherapy (IORT) during a partial mastectomy after recurrence.
Who is this for?
Women ages 50 and older with DCIS, stage I, some stage II, or some stage III node negative breast cancer that has recurred within 1 year who have received radiation therapy. You must not be receiving any neoadjuvant (before surgery) treatment, except for radiation.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT), 1 time</li> <li class="seamTextUnorderedListItem">Partial mastectomy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT) is radiation given at the time of a partial mastectomy.</li> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">A partial mastectomy is surgery to remove part of the breast and is sometimes called a lumpectomy.</li> <li class="seamTextUnorderedListItem">Node negative means cancer has not spread to your lymph nodes.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling <span class="highlight">people</span> with lobular breast cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05289466' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy/intraoperative' target='_blank'>Breastcancer.org: Intraoperative Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/oncoplastic-lumpectomy' target='_blank'>Breastcancer.org: Partial Mastectomy</a> </li></ul>
3
NEAREST SITE: 680 miles
Swedish Cancer Institute
Seattle,WA
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT03513614
Lymph Node Surgery and Radiation for Stage II-III Node Positive Breast Cancer
Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS). A Multicenter Randomized Phase III Trial (OPBC-03/ SAKK 23/16 /IBCSG 57-18 / ABCSG-53 / GBG-101) Scientific Title
Purpose
To study the safety, effects (good and bad), and anti-cancer activity of tailored axillary surgery (TAS) with radiation, which may reduce the need for the invasive axillary lymph node dissection (ALND) procedure.
Who is this for?
People with stage II or stage III node positive breast cancer who are planning to receive surgery for a new diagnosis, recurrence, or second diagnosis. You must not have received radiation.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tailored axillary surgery (TAS)</li> <li class="seamTextUnorderedListItem">Radiation</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tailored axillary surgery (TAS)</li> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND)</li> <li class="seamTextUnorderedListItem">Radiation</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The removal of all lymph nodes in the armpit, called axillary lymph node dissection (ALND), is standard care for many <span class="highlight">people</span> with breast cancer.</li> <li class="seamTextUnorderedListItem">However, ALND is an invasive procedure and can cause side effects such as lymphedema (swelling), problems with shoulder mobility, nerve problems, and long-term pain.</li> <li class="seamTextUnorderedListItem">The surgery being studied in this trial is called tailored axillary surgery (TAS). </li> <li class="seamTextUnorderedListItem">TAS aims to remove only the lymph nodes with cancer cells and is less invasive than ALND.</li> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">Node positive means that cancer has spread to the lymph nodes.</li> <li class="seamTextUnorderedListItem">Recurrence means that cancer has come back.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03513614' target='_blank'>ClinicalTrials.gov</a> </li></ul>
4
NEAREST SITE: 1509 miles
UT Southwestern Medical Center
Dallas,TX
VISITS: 1 visit that coincides with surgery
PHASE: I-II
NCT ID: NCT02807597
Using an Experimental Technique to Look for Cancer Cells During a Lumpectomy (Breast Conserving Surgery)
Evaluation of LS301 Uptake in Tumors of Patients Undergoing Partial Mastectomy and Sentinel Lymph Node Biopsy for Breast Cancer Scientific Title
Purpose
To study if using an experimental imaging technique during a lumpectomy -- using the dye LS301 and Cancer Vision Goggles -- can help determine if all the tumor and cancer cells have been removed from the breast.
Who is this for?
People with stage I or stage II breast cancer who will be receiving a lumpectomy (breast conserving surgery).
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LS301, by IV, 4 to 24 hours before surgery</li> <li class="seamTextUnorderedListItem">Lumpectomy (breast conserving surgery)</li> <li class="seamTextUnorderedListItem">A Cancer Vision Goggles review of the breast tissue removed during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The goal of a lumpectomy is to remove all of the tumor and a rim of normal tissue from around the tumor. The rim of normal tissue is also called the margin or surgical margin. </li> <li class="seamTextUnorderedListItem">During or after surgery, the margin will be looked at by a type of doctor called a pathologist to see if there are any cancer cells in the margin. </li> <li class="seamTextUnorderedListItem">It may affect your treatment plan if cancer cells are found in the margin. Some <span class="highlight">people</span> with cancer cells in the margin may need more surgery and/or radiation. </li> <li class="seamTextUnorderedListItem">This trial is studying a new technique to determine if there are cancer cells in the margin--the technique uses the dye LS301 and Cancer Vision Goggles. </li> <li class="seamTextUnorderedListItem">LS301 is injected into your body, and then attaches itself to cancer cells in your breast. </li> <li class="seamTextUnorderedListItem">Cancer Vision Goggles are experimental glasses that allow a surgeon to see any cancer cells LS301 has attached to in the breast.</li> <li class="seamTextUnorderedListItem">Research suggests that using LS301 and Cancer Vision Goggles together may allow surgeons to immediately see if they have removed all of the tumor during a lumpectomy and whether the margins are free of cancer cells.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02807597' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/diagnosis/margins' target='_blank'>Breastcancer.org: Surgical Margins</a> </li><li class='seamTextUnorderedListItem'><a href='https://source.wustl.edu/2020/03/cancerous-tumors-surrounding-cells-illuminated-by-new-imaging-agent/' target='_blank'>The Source: Cancerous Tumors, Surrounding Cells Illuminated by New Imaging Agent</a> </li><li class='seamTextUnorderedListItem'><a href='https://outlook.wustl.edu/2014/aug/seeing-cancer/' target='_blank'>Outlook Magazine: Cancer Vision</a> </li></ul>
5
NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT04703244
Registry of Samples with Residual Disease After Neoadjuvant Treatment for Stage I-III Breast Cancer
Development of Patient Derived Xenografts (PDX) in Patients With Breast Cancer Who Have Residual Disease After Neoadjuvant Systemic Therapy Scientific Title
Purpose
To use blood and tissue samples to find ways to treat people with breast cancer in the future.
Who is this for?
People with stage I, stage II, or stage III breast cancer who are receiving chemotherapy or hormone therapy before surgery (neoadjuvant).
Full eligibility criteria
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<p class="seamTextPara"> You will provide the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood samples</li> <li class="seamTextUnorderedListItem">Tissue samples during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">People with breast cancer who receive treatment before surgery (neoadjuvant) and still have breast cancer at the time of surgery have a high (greater than 50%) risk of cancer coming back. Cancers like this may be different than ones in which there is no cancer remaining after neoadjuvant treatment.</li> <li class="seamTextUnorderedListItem">Cancer tissue from surgery will be used to grow the cancer in a lab to study why it is different and how to treat it.</li> <li class="seamTextUnorderedListItem">Blood samples will be used to look at biomarkers to study how the cancer is different and find new ways to identify and treat it.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04703244' target='_blank'>ClinicalTrials.gov</a> </li></ul>
6
NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT03941756
Procedure During Lymph Node Surgery to Prevent Lymphedema for Stage III Breast Cancer
Prophylactic Lymphovenous Bypass Procedure Following Axillary Lymphadenectomy in Patients With Inflammatory Breast Cancer: A Prospective, Randomized Study Scientific Title
Purpose
To study if a procedure called lymphovenous bypass completed during lymph node surgery can prevent lymphedema (arm swelling).
Who is this for?
People with advanced or inflammatory (some stage III) breast cancer who are planning to receive lymph node surgery (axillary lymph node dissection) and radiation.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Indocyanine green, by IV</li> <li class="seamTextUnorderedListItem">Imaging to see lymph nodes</li> <li class="seamTextUnorderedListItem">Lymphovenous bypass during lymph node surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Usual Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care during lymph node surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that develops as a side effect of breast cancer treatments like surgery and radiation therapy.</li> <li class="seamTextUnorderedListItem">Lymphedema can affect arm function and quality of life.</li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND).</li> <li class="seamTextUnorderedListItem">The lymphovenous bypass procedure creates a path for lymph fluid to flow away from the arms. It is usually done after a diagnosis of lymphedema.</li> <li class="seamTextUnorderedListItem">Performing lymphovenous bypass before underarm lymph node surgery may help prevent lymphedema from forming.</li> <li class="seamTextUnorderedListItem">Indocyanine green (ICG) is a tracer routinely used for lymph node surgery that helps locate cancer in the body.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling <span class="highlight">people</span> with other types of cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03941756' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/about-your-lymphovenous-bypass-lvb-surgery-lymphedema' target='_blank'>Memorial Sloan Kettering Cancer Center: About Your Lymphovenous Bypass (LVB) Surgery for Lymphedema</a> </li></ul>
7
NEAREST SITE: 1643 miles
Baylor Medicine
Houston,TX
VISITS: 1 visit, then coincides with surgery
PHASE: NA
NCT ID: NCT03796559
Magseed Marker to Identify Axillary Lymph Nodes Before Surgery for Stage I-III Breast Cancer
A Prospective Open Label Study of the Use of Magseed® Markers and Sentimag® to Localize Axillary Lymph Nodes With Biopsy-proven Metastases in Breast Cancer Patients (MAGELLAN) Scientific Title
Purpose
To study the accuracy and safety of using Magseed markers to help doctors identify axillary lymph nodes and plan surgery.
Who is this for?
People with stage I, stage II, or some stage III node positive breast cancer who are planning to receive chemotherapy before surgery (neoadjuvant).
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placement of Magseed marker with ultrasound, before chemotherapy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Magseed is a small device inserted near the lymph nodes that is used to identify axillary (armpit or underarm) lymph nodes with cancer cells.</li> <li class="seamTextUnorderedListItem">The Magseed can be seen by doctors with a handheld device during surgery.</li> <li class="seamTextUnorderedListItem">The Magseed is removed during surgery along with the positive lymph nodes.</li> <li class="seamTextUnorderedListItem">Node positive means that cancer has spread to the lymph nodes.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03796559' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.endomag.com/patients/magseed-marker-patient-guide/' target='_blank'>Hologic: Magseed® Marker</a> </li></ul>
8
NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX
VISITS: Coincides with surgery
PHASE: II-III
NCT ID: NCT05766891
Hypnosis During Lumpectomy to Reduce Pain and Pain Medication for Stage 0-I Breast Cancer
Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery Scientific Title
Purpose
To study whether hypnosedation before and during breast cancer surgery reduces the use of pain medication, reduces pain and stress, and leads to faster recovery.
Who is this for?
People newly diagnosed with stage 0 (DCIS) or stage I breast cancer who are planning to receive a lumpectomy and have not yet received any treatment.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnosedation before and during surgery</li> <li class="seamTextUnorderedListItem">General anesthesia during surgery (if needed)</li> <li class="seamTextUnorderedListItem">Local anesthesia</li> <li class="seamTextUnorderedListItem">Medication for pain and nausea</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnosedation before surgery</li> <li class="seamTextUnorderedListItem">General anesthesia during surgery</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General anesthesia during surgery</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">For local anesthesia, you are awake but receive medicine to numb the breast during surgery.</li> <li class="seamTextUnorderedListItem">For general anesthesia, you are asleep during surgery.</li> <li class="seamTextUnorderedListItem">Hypnosedation allows the patient to dissociate from the place they're in and become deeply relaxed. This may allow the use of local rather than general anesthesia.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05766891' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/cancer-frontline/breast-cancer-surgery-without-anesthesia.h00-159225723.html' target='_blank'>MD Anderson Cancer Center: Hypnosedation for Some Breast Cancer Surgeries</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tmc.edu/news/2018/03/hypnosis-operating-room/' target='_blank'>Texas Medical Center: Hypnosis in the Operating Room</a> </li></ul>
9
NEAREST SITE: 1643 miles
MD Anderson
Houston,TX
VISITS: 1 visit that coincides with surgery
PHASE: NA
NCT ID: NCT04606030
Using a Biobridge Scaffold During Lymphedema Surgery
LymphBridge: Prospective Evaluation of the BioBridge Scaffold as an Adjunct to Lymph Node Transplant for Upper Extremity Lymphedema Scientific Title
Purpose
To investigate the safety and effects (good and bad) of using an experimental device called a Biobridge scaffold during surgery to treat lymphedema.
Who is this for?
People who have completed breast cancer treatment at least three years ago, have no evidence of disease, and have been diagnosed with lymphedema.
Full eligibility criteria
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- What's being studied?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT) </li> <li class="seamTextUnorderedListItem">BioBridge Collagen Matrix inserted into your body during surgery </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that may develop as a side effect of some breast cancer therapies. </li> <li class="seamTextUnorderedListItem">Lymphedema happens when there is a blockage in your lymphatic system (a part of your immune system) that stops the lymph fluid from draining well. The fluid buildup causes the abnormal swelling. </li> <li class="seamTextUnorderedListItem">The surgery used in this trial to help with your lymphedema is called a vascularized lymph node transfer.</li> <li class="seamTextUnorderedListItem">Your doctor will insert a Biobridge scaffold during your vascularized lymph node transfer. </li> <li class="seamTextUnorderedListItem">The Biobridge scaffold is made of collagen and may help lymph vessels grow around lymph blockages.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04606030' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/conditions-and-diseases/breast-cancer/breast-cancer-lymphedema-after-treatment' target='_blank'>Johns Hopkins Medicine: Breast Cancer, Lymphedema After Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://intermountainhealthcare.org/services/cancer-care/treatments-and-procedures/lymphedema-treatment/our-services/vascularized-lymph-node-transfer/' target='_blank'>Intermountain Healthcare: Vascularized Lymph Node Transfer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fibralignbio.com/biobridge-2/' target='_blank'>Fibralign Corporation Medical Device Information Page: Biobridge</a> </li></ul>
10
NEAREST SITE: 1643 miles
Baylor College Of Medicine
Houston,TX
VISITS: Coincides with surgery
PHASE: III
NCT ID: NCT04722692
Non-Radioactive Tracer During Surgery for Women with Stage 0 (DCIS or LCIS) Breast Cancer or Women at High Risk for Breast Cancer
Sentinel Lymph Node Biopsy in Ductal Cancer in Situ or Unclear Lesions of the Breast and How to Not do it. An Open-label, Phase 3, Randomised Controlled Trial. (SentiNot 2.0). Scientific Title
Purpose
To study how well a non-radioactive tracer helps surgeons see sentinel lymph nodes during surgery.
Who is this for?
Women with stage 0 (DCIS or LCIS) breast cancer or women who are at high risk for breast cancer who are planning to receive surgery.
Full eligibility criteria
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- What's being studied?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery with non-radioactive tracer, by injection</li> </ul> <p class="seamTextPara"> If cancer is found in the samples removed during surgery, then you will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery to remove sentinel lymph nodes with non-radioactive main tracer</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery to remove sentinel lymph nodes with radioactive main tracer</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This trial also helps <span class="highlight">people</span> avoid an unnecessary (not needed) second surgery if no cancer is found in the tissue removed during their first surgery.</li> <li class="seamTextUnorderedListItem">A sentinel lymph node biopsy is used to see if breast cancer cells are found in the sentinel node, the first lymph node under the arm to which the cancer cells are most likely to have spread.</li> <li class="seamTextUnorderedListItem">Tracers are dyes or substances used during surgery or scans to help doctors see inside your body.</li> <li class="seamTextUnorderedListItem">The standard of care tracer is radioactive.</li> <li class="seamTextUnorderedListItem">In this study, the experimental tracer is called superparamagnetic iron oxide (SPIO). It is magnetic instead of radioactive.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04722692' target='_blank'>ClinicalTrials.gov</a> </li></ul>
11
NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO
VISITS: Coincides with surgery or routine care, then 1-2 visits every year for 5 years
PHASE: NA
NCT ID: NCT05505643
Cryoablation Compared to Lumpectomy for Women with Stage I HR+, HER2- Breast Cancer
COOL-IT: Cryoablation vs Lumpectomy in T1 Breast Cancers: A Randomized Controlled Trial With Safety Lead-in Scientific Title
Purpose
To compare the safety, effects (good and bad), and anti-cancer activity of cryoablation and lumpectomy.
Who is this for?
Women at least 50 years old with stage I hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who are not planning on receiving neoadjuvant (before surgery) chemotherapy. You must not have a BRCA1 or BRCA2 mutation.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation with Endocare(TM) SlimLine(TM) Cryoprobe</li> <li class="seamTextUnorderedListItem">MRI scan, after 6 months</li> <li class="seamTextUnorderedListItem">Mammogram, every year for 5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lumpectomy</li> <li class="seamTextUnorderedListItem">MRI scan, after 6 months</li> <li class="seamTextUnorderedListItem">Mammogram, every year for 5 years</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The standard approach (standard of care) for <span class="highlight">people</span> with this kind of breast cancer is a lumpectomy. A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">Cryoablation is a method of killing a tumor by freezing it.</li> <li class="seamTextUnorderedListItem">Endocare(TM) SlimLine(TM) Cryoprobe is designed to deliver cold temperatures for cryoablation.</li> <li class="seamTextUnorderedListItem">If you are in group 1 and experience recurrence (cancer coming back), you may choose to receive a lumpectomy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05505643' target='_blank'>ClinicalTrials.gov</a> </li></ul>
12
NEAREST SITE: 2371 miles
University of Virginia
Charlottesville,VA
VISITS: 1-2 visits within 8 days
PHASE: I
NCT ID: NCT04796220
Thermal Treatment and Chemotherapy Before Surgery for Stage I-III Breast Cancer
Focused Ultrasound With Low-Dose Gemcitabine to Augment Immune Control of Early Stage Breast Cancer Scientific Title
Purpose
To study the safety, effects (good and bad), and anti-cancer activity of EchoPulse ultrasound ablation and gemcitabine (Gemzar®) chemotherapy alone or together before surgery (neoadjuvant).
Who is this for?
People with newly diagnosed stage I, stage II, or stage III breast cancer who have not yet received treatment.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, 1 time</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation of tumor, 1 time</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, 1 time</li> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation of tumor, 1 time</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation applies high-intensity focused ultrasound waves to a tumor, which ablates (heats) the tumor tissue to kill cancer cells.</li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®) is a type of chemotherapy that kills cancer cells.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment, like chemotherapy, before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04796220' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.theraclion.com/products/echopulse/' target='_blank'>Theraclion: EchoPulse Ultrasound Ablation</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/treatments/16541-hifu-high-intensity-focused-ultrasound' target='_blank'>Cleveland Clinic: High-Intensity Focused Ultrasound</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/drugs/gemzar' target='_blank'>Breastcancer.org: Gemcitabine (Gemzar®)</a> </li></ul>
13
NEAREST SITE: 2427 miles
Advent Winter Garden
Winter Garden,FL
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT06572410
Lumpectomy with EnVisio Navigation System for Women with Stage 0-III Breast Cancer
Prospective Analysis of EnVisio Spatial Intelligence for Soft Tissue Localization and Guided Surgical Excision Scientific Title
Purpose
To study the ability of a lumpectomy with the EnVisio Surgical Navigation system to result in a negative margin.
Who is this for?
Women with stage 0 (DCIS), stage I, stage II, or some stage III breast cancer who are planning to receive a lumpectomy.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lumpectomy with the EnVisio Navigation System</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The EnVisio Surgical Navigation system may allow precise removal of breast tumors and result in a negative margin.</li> <li class="seamTextUnorderedListItem">A negative margin is the presence of a border of healthy tissue around the tumor. Obtaining a negative margin increases the likelihood that all cancer cells were removed during surgery.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling <span class="highlight">people</span> with other types of breast cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06572410' target='_blank'>ClinicalTrials.gov</a> </li></ul>
14
NEAREST SITE: 2510 miles
Naval Medical Center Portsmouth
Portsmouth,VA
VISITS: Coincides with surgery
PHASE: IV
NCT ID: NCT06252662
Comparing 2 Combinations of Pain Medication for Mastectomy
Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in an Erector Spinae Plane Block for Mastectomies in Cancer Patients: a Randomized Control Trial Scientific Title
Purpose
To compare 2 combinations of medications to control pain for people receiving a mastectomy.
Who is this for?
People with stage I, stage II, or stage III breast cancer or people at high risk of breast cancer who are planning to receive a mastectomy.
Full eligibility criteria
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- What's involved?
- What's being studied?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bupivacaine and dexmedetomidine, by injection guided by ultrasound</li> <li class="seamTextUnorderedListItem">Pain questionnaires after surgery, at hospital and at home</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bupivacaine and liposomal bupivacaine, by injection guided by ultrasound</li> <li class="seamTextUnorderedListItem">Pain questionnaires after surgery, at hospital and at home</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bupivacaine is a common method to control pain after surgery performed on the chest and chest wall.</li> <li class="seamTextUnorderedListItem">Liposomal bupivacaine is a different version of bupivacaine.</li> <li class="seamTextUnorderedListItem">Dexmedetomidine is a pain medication used for other surgeries that may be better than the standard of care for mastectomies.</li> <li class="seamTextUnorderedListItem">An ultrasound will be used to find the correct place to inject the pain medication.</li> <li class="seamTextUnorderedListItem">A mastectomy is sometimes called a partial mastectomy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06252662' target='_blank'>ClinicalTrials.gov</a> </li></ul>
15
NEAREST SITE: 2519 miles
Thomas Jefferson University Hospital
Philadelphia,PA
VISITS: 5 visits
PHASE: NA
NCT ID: NCT04959474
Reducing Calories During Radiation Therapy for DCIS or Stage I-III Breast Cancer
SABR-CaRe: A Phase II Randomized Trial of Pre-Operative Stereotactic Ablative Radiation Therapy (SABR) With and Without Caloric Restriction for Early Stage Breast Cancer Scientific Title
Purpose
To determine if neoadjuvant (before surgery) calorie restriction during radiation therapy decreases the size of tumor tissue, compared to radiation therapy alone.
Who is this for?
People age 40 and older with DCIS, stage I, stage II, or stage III node negative breast cancer or age 50 and older if you have triple negative (ER-, PR-, HER2-) breast cancer. You must have not yet received chemotherapy, radiation, or surgery.
Full eligibility criteria
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic ablative radiation therapy (SABR) is a highly focused radiation treatment that gives an intense dose of radiation concentrated on a tumor, while limiting the dose to the surrounding organ.</li> <li class="seamTextUnorderedListItem">Giving SABR before surgery may make the tumor smaller.</li> <li class="seamTextUnorderedListItem">Adding dietary restriction to radiation therapy may help increase the effectiveness of the radiation and decrease the spread of the cancer to other places in the body.</li> <li class="seamTextUnorderedListItem">The reduced calorie diet consists of reducing your calorie intake by 25%.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04959474' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://stanfordhealthcare.org/medical-treatments/s/stereotactic-body-radiation-therapy.html#:~:text=Stereotactic%20ablative%20radiotherapy%20(SABR)%2C,dose%20to%20the%20surrounding%20organs.' target='_blank'>Stanford: Stereotactic Ablative Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.jefferson.edu/university/jmc/departments/radiation_oncology/news/07212014.html' target='_blank'>Thomas Jefferson University: Calorie Restriction and Breast Cancer</a> </li></ul>
16
NEAREST SITE: 2591 miles
University of Miami
Miami,FL
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT04998682
Removing Lymph Nodes During Surgery for Stage III Breast Cancer
TAD: Prospective Evaluation of Targeted Axillary Dissection After Neoadjuvant Systemic Therapy in Patients With Breast Cancer With Advanced Nodal Disease at Diagnosis Scientific Title
Purpose
To determine if examining axillary (underarm/armpit) lymph nodes provides information to determine if fewer lymph nodes can be removed during surgery.
Who is this for?
People with some stage III node positive breast cancer who have received neoadjuvant (before surgery) chemotherapy and are planning to receive surgery.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Removal of axillary lymph nodes during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The surgery that examines and/or removes lymph nodes from your underarm/armpit area is called a targeted axillary dissection (TAD), sometimes also called an axillary lymph node dissection (ALND). </li> <li class="seamTextUnorderedListItem">During surgery, a blue dye will be used to see your lymph nodes and the lymphatic channels that drain your arm.</li> <li class="seamTextUnorderedListItem">Node positive means cancer has spread to your lymph nodes.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04998682' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph-node-removal/axillary-dissection' target='_blank'>Breastcancer.org: Axillary Lymph Node Dissection</a> </li></ul>
17
NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA
VISITS: 6 visits within 2 years
PHASE: NA
NCT ID: NCT04636710
Imaging to Identify Lymph Nodes and Limit Lymph Node Removal for Women with Stage III Inflammatory Breast Cancer
Refining Local-Regional Therapy for Inflammatory Breast Cancer (IBC) Scientific Title
Purpose
To identify the first lymph nodes that drain the breast to limit lymph node removal and reduce the risk of lymphedema in women with inflammatory breast cancer.
Who is this for?
Women with stage III inflammatory breast cancer who have not yet received treatment.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphoscintigraphy with radioactive dye, by injection, 2 times</li> <li class="seamTextUnorderedListItem">Lymph node surgery</li> <li class="seamTextUnorderedListItem">Questionnaires, 6 times within 2 years</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A lymphoscintigraphy, also called sentinel lymph node mapping, is an imaging procedure used to identify how lymph nodes drain.</li> <li class="seamTextUnorderedListItem">It is used to evaluate if breast cancer has spread to the axillary lymph nodes (lymph nodes under the arm) in non-inflammatory breast cancer.</li> <li class="seamTextUnorderedListItem">In non-inflammatory breast cancer, these lymph nodes are tested first, and if they are free of cancer, additional lymph nodes are not removed. </li> <li class="seamTextUnorderedListItem">By safely limiting lymph node removal, the likelihood of developing lymphedema (arm swelling) has been reduced in <span class="highlight">people</span> with non-inflammatory breast cancer.</li> <li class="seamTextUnorderedListItem">It is not known whether lymphoscintigraphy can safely reduce lymph node removal and lymphedema in <span class="highlight">people</span> with inflammatory breast cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04636710' target='_blank'>ClinicalTrials.gov</a> </li></ul>
