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Find Breast Cancer Clinical Trials That Are Right For You

The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.

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(Last updated: December 03, 2024)

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AKT

ALK

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CHEK2 or CHEK1

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RAS (KRAS or NRAS)

ROS1

TP53

NEAREST SITE: 3 miles
UCSF Medical Center at Mission Bay
San Francisco,CA

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT05456373

Device to Detect Positive Margins During Lumpectomy

Intraoperative Use of ClearEdge Device in Breast Conserving Surgery Scientific Title

Purpose

To study whether the ClearEdge tissue imaging device helps detect positive margins during a lumpectomy.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who are planning to receive a lumpectomy. You must not have received chemotherapy or radiation to the affected breast. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care assessment of margins during surgery</li> <li class="seamTextUnorderedListItem">ClearEdge tissue imaging device</li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care assessment of margins during surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The ClearEdge tissue imaging device uses a new technology to help the surgeon detect tissue abnormalities during surgery and identify cancer cells that would have been left behind (positive margins).</li> <li class="seamTextUnorderedListItem">This may allow the surgeon to remove all cancer cells during surgery and avoid cancer recurrence or the need to repeat surgery.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy. It is a standard of care (routine) procedure that removes the tumor and a rim of surrounding normal tissue (margins) while leaving as much normal breast tissue as possible.</li> <li class="seamTextUnorderedListItem">A margin that does not contain tumor cells is called a negative margin and tells the surgeon that the tumor has been removed. A positive margin contains tumor cells at or near the edge of the tissue removed.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05456373' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy' target='_blank'>Breastcancer.org: Lumpectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/margin' target='_blank'>National Cancer Institute: Clear Margins</a> </li><li class='seamTextUnorderedListItem'><a href='https://lsbiopath.com/patient/' target='_blank'>LSBiopath: ClearEdge Device Information Page</a> </li></ul>

NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: Coincides with surgery

PHASE: II

NCT ID: NCT05020574

Impact of Antibiotics on Infection and the Microbiome in People Receiving a Mastectomy

Microbiome and Association With Implant Infections: Investigating the Impact of Antibiotics on the Gut and Breast Microbiomes Post-mastectomy With Implant-based Breast Reconstruction Scientific Title

Purpose

To study the effects (good and bad) of antibiotics after mastectomy with immediate reconstruction on infection and the microbiome.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or some stage III breast cancer or people at risk of breast cancer who are planning to receive a mastectomy with immediate reconstruction. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, before and during surgery</li> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, daily for at least 7 days after surgery</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, before and during surgery</li> <li class="seamTextUnorderedListItem">No antibiotics after surgery (unless infection occurs)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A mastectomy is surgery to remove a breast.</li> <li class="seamTextUnorderedListItem">Women with a strong family history of breast cancer or a BRCA mutation may choose to undergo a mastectomy to reduce their risk of developing breast cancer.</li> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) is an antibiotic used to prevent infection after surgery.</li> <li class="seamTextUnorderedListItem">The microbiome consists of the many bacteria, viruses, and fungi found on your body.</li> <li class="seamTextUnorderedListItem">The harmful bacteria cause disease such as infection, and the beneficial bacteria help keep you healthy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05020574' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a682733.html' target='_blank'>MedlinePlus: Cephalexin (Keflex®)</a> </li></ul>

NEAREST SITE: 28 miles
Stanford Hospital and Clinics
Palo Alto,CA

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT05975359

Comparing Drains During Bilateral Mastectomy with Immediate Breast Reconstruction

A Pilot Study of the Interi Manifold With Traditional Surgical Drains in Implant-Based Breast Reconstruction Scientific Title

Purpose

To compare the safety and effects (good and bad) of Interi Drains to standard of care Jackson-Pratt (JP) Drains during bilateral (both breast) mastectomy.

Who is this for?

Women 18-65 years old with stage I, stage II, or stage III breast cancer who are planning to receive a bilateral (both breasts) mastectomy with immediate reconstruction. Full eligibility criteria

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You will receive the following during surgery: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Interi Drain on 1 breast</li> <li class="seamTextUnorderedListItem">Jackson-Pratt (JP) Drain on 1 breast</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Drain log, daily</li> <li class="seamTextUnorderedListItem">Drain removal, 1-3 weeks after surgery</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">During implant-based breast reconstruction, surgical drains are placed to prevent fluid build up.</li> <li class="seamTextUnorderedListItem">The most frequently used drain is a Jackson-Pratt (JP) Drain.</li> <li class="seamTextUnorderedListItem">The Interi Drain system may work better than the JP Drain system.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05975359' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 74 miles
University of California, Davis
Sacramento,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT06103669

Adding Radiation to Treatment for People with Metastatic Oligoprogressive Breast Cancer

Locally ablatiVe therApy in oLigO-pRogressive sOlid tUmorS (VALOROUS) Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of adding radiation to metastatic breast cancer treatment.

Who is this for?

People with metastatic (stage IV) oligoprogressive breast cancer who have received at least 1 line of therapy for metastatic disease. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation or interventional radiology ablation</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">Interventional radiology ablation uses heat or cold to kill cancer cells.</li> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Oligoprogressive disease refers to progression of only a few sites of metastasis.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06103669' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://studypages.com/en/s/a-study-of-ablative-therapy-in-people-with-progressive-solid-tumors-valorous-278307/?ref=gallery' target='_blank'>University of California, Davis: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.columbiaradiology.org/patients/services/interventional-radiology/tumor-ablation' target='_blank'>Columbia University: Interventional Radiology Ablation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/treatment/radiotherapy/external/types/stereotactic-body-radiotherapy-sbrt' target='_blank'>Cancer Research UK: Stereotactic Radiotherapy</a> </li></ul>

NEAREST SITE: 339 miles
Providence Saint John's Hospital
Santa Monica,CA

VISITS: May require hospitalization

PHASE: NA

NCT ID: NCT05289466

Intraoperative Radiotherapy During Partial Mastectomy for Women Ages 50+ with Recurrent DCIS or Stage I-III Breast Cancer

Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of intraoperative radiotherapy (IORT) during a partial mastectomy after recurrence.

Who is this for?

Women ages 50 and older with DCIS, stage I, some stage II, or some stage III node negative breast cancer that has recurred within 1 year who have received radiation therapy. You must not be receiving any neoadjuvant (before surgery) treatment, except for radiation. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT), 1 time</li> <li class="seamTextUnorderedListItem">Partial mastectomy</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT) is radiation given at the time of a partial mastectomy.</li> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">A partial mastectomy is surgery to remove part of the breast and is sometimes called a lumpectomy.</li> <li class="seamTextUnorderedListItem">Node negative means cancer has not spread to your lymph nodes.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with lobular breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05289466' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy/intraoperative' target='_blank'>Breastcancer.org: Intraoperative Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/oncoplastic-lumpectomy' target='_blank'>Breastcancer.org: Partial Mastectomy</a> </li></ul>

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA

VISITS: May require hospitalization

PHASE: III

NCT ID: NCT04365374

Gamma Tile Surgically Targeted Radiation Therapy after Brain Surgery for Brain Metastasis

A Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT) Versus Surgically Targeted Radiation Therapy (STaRT) With Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors. Scientific Title

Purpose

To compare the safety, effects (good and bad), and anti-cancer activity of Gamma Tile Surgically Targeted Radiation Therapy (STaRT) and stereotactic radiation after brain surgery.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis). You must have 1-4 brain tumors that have not been treated with radiation. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove tumor and implant Gamma Tile device</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gamma Tile Surgically Targeted Radiation Therapy (STaRT)</li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove tumor</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognitive testing</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gamma Tile Surgically Targeted Radiation Therapy (STaRT) is a FDA-cleared radiation therapy.</li> <li class="seamTextUnorderedListItem">Gamma Tile is a device implanted during surgery that delivers radiation directly to the tumor, called Surgically Targeted Radiation Therapy (STaRT).</li> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Additional brain tumors not removed during surgery will be treated with stereotactic radiation alone, which is standard of care.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04365374' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 342 miles
Office of Dennis R. Holmes, M.D., F.A.C.S.
Glendale,CA

VISITS: 2 visits

PHASE: NA

NCT ID: NCT05218044

Cryoablation Minimally Invasive Alternative to Surgery for Women with DCIS

Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ Scientific Title

Purpose

To study the effects (good and bad) and anti-cancer activity of cryoablation, an experimental alternative to surgery.

Who is this for?

Women with ductal carcinoma in situ (DCIS) who have not received surgery or radiation. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation, 1 time</li> </ul> followed 6 months later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation is an experimental minimally invasive, cost effective alternative to surgery that is currently being evaluated for early stage breast cancer.</li> <li class="seamTextUnorderedListItem">Cryoablation involves insertion of a probe into the breast that freezes and destroys the abnormal tissue.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05218044' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://helenreybreastcancerfoundation.com/dcis-cryoablation-study' target='_blank'>Helen Rey Breast Cancer Foundation: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cryoablation' target='_blank'>National Cancer Institute: Cryoablation</a> </li></ul>

NEAREST SITE: 353 miles
City of Hope
Duarte,CA

VISITS: 2 visits within 1.5 months

PHASE: NA

NCT ID: NCT03463954

Novilase® Laser Ablation Before Surgery for Women with Stage I-II BRCA Negative Breast Cancer

Prospective, Multicenter Confirmatory Clinical Evaluation of Novilase® Interstitial Laser Therapy for the Focal Destruction of Malignant Breast Tumors ≤15 mm (BR-003) Scientific Title

Purpose

To compare the safety, effects (good and bad), and anti-cancer activity of Novilase® laser ablation to standard of care lumpectomy for small tumors.

Who is this for?

Women with some stage I or stage II breast cancer who have not yet received surgery. You must not have BRCA positive, lobular, or triple negative breast cancer. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Novilase® laser ablation</li> </ul> followed 1-1.5 months later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery to remove tumor</li> <li class="seamTextUnorderedListItem">MRI scan</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Novilase® laser ablation system kills tumor cells by heating the tissue with a laser.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03463954' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://novilase.com/' target='_blank'>Novian Health: Novilase®</a> </li></ul>

NEAREST SITE: 657 miles
Arizona Center for Cancer Care
Scottsdale,AZ

VISITS: 1 visit that coincides with surgery

PHASE: NA

NCT ID: NCT04397185

Comparing Two Surgical Techniques to Locate Tumors During a Lumpectomy (Breast Conserving Surgery)

Randomized Prospective Trial of Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer Scientific Title

Purpose

To study if an experimental technique is as safe and effective at locating non-palpable tumors during a lumpectomy as the standard of care.

Who is this for?

Women with DCIS or breast cancer whose tumor is at least 1 cm and not palpable (able to be felt by touch) and who will be receiving a lumpectomy (breast conserving surgery). Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Breast Cancer Locator <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast Cancer Locator used during lumpectomy (breast conserving surgery)</li> </ul> Group 2: Standard of care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Wire localizer used during lumpectomy (breast conserving surgery)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast tumors are non-palpable, this means they cannot be felt by touch.</li> <li class="seamTextUnorderedListItem">A wire localizer lumpectomy is when a radiologist inserts a thin wire into the area of the breast with the tumor. The surgeon then uses this wire to find non-palpable tumors.</li> <li class="seamTextUnorderedListItem">The Breast Cancer Locator is a personalized 3D form of the breast. It is an experimental technique that helps the surgeon locate non-palpable tumors during a lumpectomy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04397185' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.brighamandwomens.org/assets/BWH/surgery/surgical-oncology/pdfs/wire-guided-lumpectomy.pdf' target='_blank'>Brighman and Women's Hospital: Wire-Guided Lumpectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/treatment/type/surgery/lumpectomy/procedure-information/' target='_blank'>Susan G. Komen: Lumpectomy -- The Procedure</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cairnsurgical.com/breast-cancer-locator/' target='_blank'>CairnSurgical Information Page: Breast Cancer Locator</a> </li></ul>

NEAREST SITE: 1418 miles
University of Nebraska Medical Center
Omaha,NE

VISITS: May require hospitalization

PHASE: NA

NCT ID: NCT01535430

Studying Speech, Movement, and Senses During Brain Surgery for Brain Metastasis

Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors Scientific Title

Purpose

To study how brain tumors affect your speech, movement, and senses and to develop new methods of diagnosing brain tumors.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognitive testing</li> <li class="seamTextUnorderedListItem">MRI and fMRI scans</li> <li class="seamTextUnorderedListItem">DTI tractograms</li> <li class="seamTextUnorderedListItem">MEG studies</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Awake brain mapping and surgery to remove brain tumor</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A craniotomy is a type of brain surgery. The surgeon will remove part of your skull (cranium) to access your brain to remove the tumors.</li> <li class="seamTextUnorderedListItem">You will be awake during the craniotomy to monitor how the surgery is affecting your speech, movement, and senses. Your scalp will be anesthetized, so you will not feel the operation or any pain.</li> <li class="seamTextUnorderedListItem">You will receive cognitive testing, MRI and fMRI scans, DTI tractograms, and MEG studies before and after surgery.</li> <li class="seamTextUnorderedListItem">Cognitive tests study your cognition, which is your ability to think.</li> <li class="seamTextUnorderedListItem">Magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) scans produce brain images created by magnetic energy rather than x-ray energy.</li> <li class="seamTextUnorderedListItem">A DTI tractogram is a type of MRI scan that produces brain images created by radio waves and magnetic fields.</li> <li class="seamTextUnorderedListItem">MEG studies measure the magnetic fields produced by your brain.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01535430' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://braintumorcenter.ucsf.edu/treatments/surgery/awake-brain-mapping-faq' target='_blank'>UCSF Brain Tumor Center: Awake Craniotomy</a> </li></ul>

NEAREST SITE: 1473 miles
Integro Theranostics Research Site #3
Dallas,TX

VISITS: Coincides with surgery

PHASE: I-II

NCT ID: NCT05900986

Imaging Dye During Surgery for DCIS or Stage I-II Breast Cancer

An Open-label, Single-arm, Phase 1b/2 Study to Investigate the Safety, Efficacy and Pharmacokinetics of LS301-IT in Female Patients Undergoing Partial Mastectomy and Sentinel Lymph Node Biopsy (SLNB) for Ductal Carcinoma in Situ (DCIS) or Stage I-II Primary Invasive Breast Cancer Scientific Title

Purpose

To study the safety, best dose, and effects (good and bad) of LS301-IT, an experimental dye used to find cancer cells during surgery.

Who is this for?

Women with stage 0 (DCIS), stage I, or stage II breast cancer who are planning to receive a partial mastectomy (lumpectomy) or sentinel lymph node biopsy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LS301-IT, by IV, 1 time during surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LS301-IT is an experimental tracer for imaging scans that may help locate cancer and tumor margins in the body.</li> <li class="seamTextUnorderedListItem">Margins are the area around where the tumor was removed. A negative margin means cancer was not found in the margin, and a positive margin means cancer was found in the margin.</li> <li class="seamTextUnorderedListItem">Your surgeon may use LS301-IT to find and remove all cancer cells during surgery.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">A sentinel lymph node biopsy is used to see if breast cancer cells are found in the sentinel node, the first lymph node under the arm to which the cancer cells are most likely to have spread.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05900986' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://integrotheranostics.com/' target='_blank'>Integro Theranostics: LS301-IT</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy' target='_blank'>Breastcancer.org: Lumpectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph-node-removal/sentinel-node-dissection' target='_blank'>Breastcancer.org: Sentinel Lymph Node Biopsy</a> </li></ul>

NEAREST SITE: 1509 miles
UT Southwestern/Simmons Cancer Center-Dallas
Dallas,TX

VISITS: 4 visits

PHASE: II-III

NCT ID: NCT04715958

Ultrasound Scans to Predict Response to Chemotherapy Before Surgery for Stage I-III Breast Cancer

Monitoring Neoadjuvant Chemotherapy of Breast Cancer Using 3D Subharmonic Aided Pressure Estimation Scientific Title

Purpose

To study if ultrasound scans with perflutren (Definity®), an experimental contrast dye, can predict response to chemotherapy.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy before surgery (neoadjuvant). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ultrasound scan with perflutren (Definity®), by IV, 3 times</li> <li class="seamTextUnorderedListItem">Utrasound scan, 4 times</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Perflutren (Definity®) is an experimental contrast dye used to create better images during ultrasounds. </li> <li class="seamTextUnorderedListItem">The ability of cancer treatment to work is affected by the pressure in the cancer.</li> <li class="seamTextUnorderedListItem">Ultrasound scans use sound waves to produce images of structures within your body.</li> <li class="seamTextUnorderedListItem">The ultrasound scan in this trial, contrast-enhanced ultrasound, may be able to detect pressures in cancer and therefore predict response to chemotherapy before surgery (neoadjuvant).</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04715958' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1509 miles
UT Southwestern Medical Center
Dallas,TX

VISITS: 1 visit that coincides with surgery

PHASE: I-II

NCT ID: NCT02807597

Using an Experimental Technique to Look for Cancer Cells During a Lumpectomy (Breast Conserving Surgery)

Evaluation of LS301 Uptake in Tumors of Patients Undergoing Partial Mastectomy and Sentinel Lymph Node Biopsy for Breast Cancer Scientific Title

Purpose

To study if using an experimental imaging technique during a lumpectomy -- using the dye LS301 and Cancer Vision Goggles -- can help determine if all the tumor and cancer cells have been removed from the breast.

Who is this for?

People with stage I or stage II breast cancer who will be receiving a lumpectomy (breast conserving surgery). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LS301, by IV, 4 to 24 hours before surgery</li> <li class="seamTextUnorderedListItem">Lumpectomy (breast conserving surgery)</li> <li class="seamTextUnorderedListItem">A Cancer Vision Goggles review of the breast tissue removed during surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The goal of a lumpectomy is to remove all of the tumor and a rim of normal tissue from around the tumor. The rim of normal tissue is also called the margin or surgical margin. </li> <li class="seamTextUnorderedListItem">During or after surgery, the margin will be looked at by a type of doctor called a pathologist to see if there are any cancer cells in the margin. </li> <li class="seamTextUnorderedListItem">It may affect your treatment plan if cancer cells are found in the margin. Some people with cancer cells in the margin may need more surgery and/or radiation. </li> <li class="seamTextUnorderedListItem">This trial is studying a new technique to determine if there are cancer cells in the margin--the technique uses the dye LS301 and Cancer Vision Goggles. </li> <li class="seamTextUnorderedListItem">LS301 is injected into your body, and then attaches itself to cancer cells in your breast. </li> <li class="seamTextUnorderedListItem">Cancer Vision Goggles are experimental glasses that allow a surgeon to see any cancer cells LS301 has attached to in the breast.</li> <li class="seamTextUnorderedListItem">Research suggests that using LS301 and Cancer Vision Goggles together may allow surgeons to immediately see if they have removed all of the tumor during a lumpectomy and whether the margins are free of cancer cells.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02807597' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/diagnosis/margins' target='_blank'>Breastcancer.org: Surgical Margins</a> </li><li class='seamTextUnorderedListItem'><a href='https://source.wustl.edu/2020/03/cancerous-tumors-surrounding-cells-illuminated-by-new-imaging-agent/' target='_blank'>The Source: Cancerous Tumors, Surrounding Cells Illuminated by New Imaging Agent</a> </li><li class='seamTextUnorderedListItem'><a href='https://outlook.wustl.edu/2014/aug/seeing-cancer/' target='_blank'>Outlook Magazine: Cancer Vision</a> </li></ul>

NEAREST SITE: 1509 miles
UT Southwestern Medical Center
Dallas,TX

VISITS: Number of visits unavailable, over 2 months

PHASE: II

NCT ID: NCT03546686

Immunotherapy & Cryoablation Before Surgery in Taxane Treated Triple Negative or ER Low, HER2- Tumors

A Randomized Phase 2 Study of Peri-Operative Ipilimumab, Nivolumab and Cryoablation Versus Standard Peri-Operative Care in Women With Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer. Scientific Title

Purpose

To study the safety and effects (good and bad) of using cryoablation, ipilimumab (Yervoy®) and nivolumab (Opdivo ®) after neoadjuvant chemotherapy and before surgery.

Who is this for?

Women with stage I, stage II, or stage IIIa triple negative (ER-, PR-, HER2-) or ER Low (1%-10% ER) breast cancer who had taxane-based chemotherapy before surgery and still have some tumor remaining. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®), by IV, 1-5 days prior to core biopsy and cryoablation</li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, 1-5 days prior to core biopsy and cryoablation, and then every 2 weeks after surgery, for 6 weeks</li> <li class="seamTextUnorderedListItem">Core biopsy/Cryoablation, 7-10 days prior to surgery</li> <li class="seamTextUnorderedListItem">Breast surgery (standard-of-care) </li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation uses extreme cold to kill cancer cells. It is not an established breast cancer treatment. </li> <li class="seamTextUnorderedListItem">Yervoy is an immunotherapy. It gets the immune system to see cancer cells by blocking the CTLA-4 protein. It is approved to treat metastatic melanoma. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Opdivo is an immunotherapy that gets the immune system to go after cancer cells by blocking a protein called PD-1. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling women with triple negative as well as ER Low breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03546686' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/ipilimumab-yervoy' target='_blank'>Cancer Research UK: Ipilimumab (Yervoy)</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/Nivolumab.aspx' target='_blank'>Chemocare: Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/cryotherapy' target='_blank'>Breastcancer.org: Cryotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedaily.com/releases/2018/11/181128082721.htm' target='_blank'>Science Daily: Cryoablation</a> </li></ul>

NEAREST SITE: 1509 miles
UT Southwestern
Dallas,TX

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT05245812

Robotic Nipple Sparing Mastectomy for Women with DCIS, Stage I-III Breast Cancer, or at High Risk for Breast Cancer

Safety and Feasibility of Robotic Single-port (SP) Nipple Sparing Mastectomy: A Single Institution, Single Arm Pilot Trial Scientific Title

Purpose

To study the safety and effects (good and bad) of nipple sparing mastectomy with da Vinci single port (SP) Surgical System.

Who is this for?

Women with DCIS, stage I, stage II, or some stage III breast cancer, or at high risk for breast cancer. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nipple sparing mastectomy with da Vinci single port (SP) Surgical System</li> <li class="seamTextUnorderedListItem">Immediate breast reconstruction with tissue expanders/implants and acellular dermal matrix (Alloderm®)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A mastectomy is surgery to remove a breast.</li> <li class="seamTextUnorderedListItem">A nipple sparing mastectomy (NSM) leaves most of the healthy breast skin, including the nipple.</li> <li class="seamTextUnorderedListItem">The da Vinci single port (SP) Surgical System is an experimental surgery system designed for surgeons to perform minimally invasive surgery, such as nipple sparing mastectomy.</li> <li class="seamTextUnorderedListItem">The da Vinci SP Surgical System is approved for use during other surgeries.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05245812' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.intuitive.com/en-us/patients/procedures/general-surgery##' target='_blank'>Intuitive Surgical Device Information Page: Da Vinci Surgical System</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cedars-sinai.org/health-library/diseases-and-conditions/n/nipple-sparing-mastectomy.html' target='_blank'>Cedars-Sinai: Nipple Sparing Mastectomy</a> </li></ul>

NEAREST SITE: 1509 miles
University of Texas Southwestern
Dallas,TX

VISITS: At least 4 visits over 3 weeks including surgery; may require hospitalization

PHASE: NA

NCT ID: NCT01668082

Tissue Collection During Surgery for Brain Metastasis

An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection Scientific Title

Purpose

To collect brain tumor tissue during surgery and study brain metastasis activity with U-13C-glucose and/or 1,2-13C-acetate.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastases). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI and PET scans, 1-2 weeks before surgery</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">U-13C-glucose, by IV and/or 1,2-13C-acetate, by IV</li> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor tissue</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">On the day of surgery, you will receive U-13C-glucose and/or 1,2-13C-acetate naturally occurring chemicals to study brain metastasis activity.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01668082' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN

VISITS: Weekly study visits during radiation treatment

PHASE: NA

NCT ID: NCT02945579

Neoadjuvant Chemo & Radiation But No Surgery for Stage I-II Triple Negative or ER Low, HER2- or HER2 Positive Breast Cancer

Eliminating Breast Cancer Surgery in Exceptional Responders With Neoadjuvant Systemic Therapy Scientific Title

Purpose

To study the effects (good and bad) of avoiding surgery but still using radiation therapy in women whose biopsy shows their tumor disappeared after they received neoadjuvant chemotherapy.

Who is this for?

Women 40 or older with stage I or stage II triple negative (ER-, PR-, HER2-) or ER Low (1%-10% ER) or HER2 positive (HER2+) breast cancer. You must have already had chemotherapy to shrink your tumor, but no other treatments Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An image-guided biopsy (a biopsy that uses imaging such as CT, ultrasound, MRI or mammography)</li> <li class="seamTextUnorderedListItem">If the biopsy does not show any evidence of disease, you will then have radiation therapy</li> <li class="seamTextUnorderedListItem">If the biopsy show evidence of disease, you will have surgery then radiation therapy</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neoadjuvant chemotherapy (treatment given before surgery) is used to shrink tumors before surgery. The tumor may even disappear. When this occurs, researchers think it may be possible for patients to avoid surgery.</li> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling women with triple negative as well as ER Low breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02945579' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li></ul>

NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN

VISITS: May require hospitalization

PHASE: NA

NCT ID: NCT04047264

Microdialysis During Surgery for Metastatic Breast Cancer that has Spread to the Brain

Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies Scientific Title

Purpose

To study the safety and effects (good and bad) of the use of microdialysis catheters during surgery to collect biomarkers, which may help doctors to develop new strategies to better diagnose, monitor, and treat cancer that has spread to the brain.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis) who are planning to receive surgery to remove the tumor at Mayo Clinic (Rochester, MN). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Microdialysis during a biopsy or surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A biomarker is a gene, protein, or molecule produced by the body or tumor in a person with cancer that tells a doctor something about the cancer cells. </li> <li class="seamTextUnorderedListItem">Microdialysis is a procedure used for collecting a small volume of liquid during surgery. This liquid contains substances that may provide valuable information to doctors about the nearby cancer.</li> <li class="seamTextUnorderedListItem">Microdialysis will be performed during surgery while your brain tumor is being removed.</li> <li class="seamTextUnorderedListItem">Information collected in this study may help doctors to develop new strategies to better diagnose, monitor, and treat brain tumors.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04047264' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.news-medical.net/life-sciences/What-is-Microdialysis.aspx' target='_blank'>News Medical: What is Microdialysis?</a> </li></ul>

NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN

VISITS: At least 3 visits including surgery; may require hospitalization

PHASE: NA

NCT ID: NCT04692337

Ommaya Reservoir Placement to Collect CSF Samples for Brain Metastasis

Ommaya Reservoir Placement for Brain Tumor Biomarker Access Scientific Title

Purpose

To study the safety and effects (good and bad) of Ommaya reservoir placement that will be used to collect and study CSF samples.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis) who are planning to undergo brain surgery. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to place Ommaya reservoir</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Collection of CSF from Ommaya reservoir, 2 or more times</li> </ul> Please contact research site for schedule.
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An Ommaya reservoir will be placed during brain surgery.</li> <li class="seamTextUnorderedListItem">Ommaya reservoirs are very small plastic devices put under the scalp to give access to cerebrospinal fluid (CSF), the fluid or liquid surrounding your brain and spinal cord.</li> <li class="seamTextUnorderedListItem">CSF samples will be used to study brain cancer activity and develop new brain cancer treatments.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04692337' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/faq-about-ommaya-reservoirs-and-ommaya-taps' target='_blank'>Memorial Sloan Kettering Cancer Center: Ommaya Reservoir</a> </li></ul>

NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN

VISITS: May require hospitalization

PHASE: NA

NCT ID: NCT04810871

Brain Surgery Before Recurrence for Brain Metastasis

Surgical Resection of Latent Brain Tumors Prior to Recurrence Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of brain surgery before brain tumor recurrence.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastases) who have received treatment with chemotherapy and/or radiation. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will receive brain surgery to remove your brain tumor before the tumor comes back (recurrence).</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04810871' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05118295

SAVI Scout Device to Find Breast Tumor Before Lumpectomy for Stage I-III Breast Cancer

Single Step Lesion Annotation and Localization of Suspicious Breast Lesions Scientific Title

Purpose

To study the safety and ability of the SAVI Scout reflector to find breast tumors before a lumpectomy.

Who is this for?

People with stage I, stage II, or some stage III breast cancer who are planning to receive a lumpectomy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placement of SAVI Scout reflector in your breast or lymph node, through a needle, during mammogram or ultrasound</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The SAVI Scout reflector is an FDA-approved device that is implanted into your breast or lymph node through a needle during a mammogram or ultrasound. The device helps your surgeon find your tumor that will be removed during a lumpectomy.</li> <li class="seamTextUnorderedListItem">The SAVI Scout reflector will also be removed during a lumpectomy.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05118295' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pennmedicine.org/cancer/types-of-cancer/breast-cancer/breast-cancer-treatment/lumpectomy/savi-scout' target='_blank'>University of Pennsylvania: SAVI Scout System</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy' target='_blank'>Breastcancer.org: Lumpectomy</a> </li></ul>

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT06584396

Donating Tissue During Surgery to Study Reconstruction Risks

EMPOwER: Evaluating Mechanical Properties of Post-Mastectomy Skin Flaps to Estimate Reconstruction Risks Scientific Title

Purpose

To study tissue collected during reconstructive surgery to identify risks from reconstructive surgery and improve reconstructive surgery.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who have received a mastectomy with tissue expander replacement and are planning to receive a breast implant. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tissue collection during surgery</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The tissue being collected is called a post-mastectomy skin flap.</li> <li class="seamTextUnorderedListItem">This study may help doctors improve reconstructive surgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06584396' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Coincides with surgery

PHASE: II-III

NCT ID: NCT05766891

Hypnosis During Lumpectomy to Reduce Pain and Pain Medication for Stage 0-I Breast Cancer

Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery Scientific Title

Purpose

To study whether hypnosedation before and during breast cancer surgery reduces the use of pain medication, reduces pain and stress, and leads to faster recovery.

Who is this for?

People newly diagnosed with stage 0 (DCIS) or stage I breast cancer who are planning to receive a lumpectomy and have not yet received any treatment. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnosedation before and during surgery</li> <li class="seamTextUnorderedListItem">General anesthesia during surgery (if needed)</li> <li class="seamTextUnorderedListItem">Local anesthesia</li> <li class="seamTextUnorderedListItem">Medication for pain and nausea</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnosedation before surgery</li> <li class="seamTextUnorderedListItem">General anesthesia during surgery</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 3: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General anesthesia during surgery</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">For local anesthesia, you are awake but receive medicine to numb the breast during surgery.</li> <li class="seamTextUnorderedListItem">For general anesthesia, you are asleep during surgery.</li> <li class="seamTextUnorderedListItem">Hypnosedation allows the patient to dissociate from the place they're in and become deeply relaxed. This may allow the use of local rather than general anesthesia.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05766891' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/cancer-frontline/breast-cancer-surgery-without-anesthesia.h00-159225723.html' target='_blank'>MD Anderson Cancer Center: Hypnosedation for Some Breast Cancer Surgeries</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.tmc.edu/news/2018/03/hypnosis-operating-room/' target='_blank'>Texas Medical Center: Hypnosis in the Operating Room</a> </li></ul>

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT03941756

Procedure During Lymph Node Surgery to Prevent Lymphedema for Stage III Breast Cancer

Prophylactic Lymphovenous Bypass Procedure Following Axillary Lymphadenectomy in Patients With Inflammatory Breast Cancer: A Prospective, Randomized Study Scientific Title

Purpose

To study if a procedure called lymphovenous bypass completed during lymph node surgery can prevent lymphedema (arm swelling).

Who is this for?

People with advanced or inflammatory (some stage III) breast cancer who are planning to receive lymph node surgery (axillary lymph node dissection) and radiation. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Indocyanine green, by IV</li> <li class="seamTextUnorderedListItem">Imaging to see lymph nodes</li> <li class="seamTextUnorderedListItem">Lymphovenous bypass during lymph node surgery</li> </ul> Group 2: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care during lymph node surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that develops as a side effect of breast cancer treatments like surgery and radiation therapy.</li> <li class="seamTextUnorderedListItem">Lymphedema can affect arm function and quality of life.</li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND).</li> <li class="seamTextUnorderedListItem">The lymphovenous bypass procedure creates a path for lymph fluid to flow away from the arms. It is usually done after a diagnosis of lymphedema.</li> <li class="seamTextUnorderedListItem">Performing lymphovenous bypass before underarm lymph node surgery may help prevent lymphedema from forming.</li> <li class="seamTextUnorderedListItem">Indocyanine green (ICG) is a tracer routinely used for lymph node surgery that helps locate cancer in the body.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03941756' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/about-your-lymphovenous-bypass-lvb-surgery-lymphedema' target='_blank'>Memorial Sloan Kettering Cancer Center: About Your Lymphovenous Bypass (LVB) Surgery for Lymphedema</a> </li></ul>

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: May require hospitalization

PHASE: NA

NCT ID: NCT02754544

Brain Surgery and Electrocorticography for Brain Metastasis

Pilot Investigation of Using Electrocorticogram (ECoG) in Predicting Eloquent Cortex and Post-Operative Functional Outcomes in Patients With Brain Tumors Scientific Title

Purpose

To identify which areas of the brain are active during brain surgery and to improve the safety of brain surgery.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis) that are planning to receive brain surgery at the University of Texas M. D. Anderson Cancer Center. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> <li class="seamTextUnorderedListItem">Electrocorticography</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">During brain surgery, you will complete various tasks to allow doctors to identify which areas of the brain are active during brain surgery, which is called electrocorticography.</li> <li class="seamTextUnorderedListItem">Tasks include speaking and moving parts of your body.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02754544' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 1643 miles
MD Anderson
Houston,TX

VISITS: 1 visit that coincides with surgery

PHASE: NA

NCT ID: NCT04606030

Using a Biobridge Scaffold During Lymphedema Surgery

LymphBridge: Prospective Evaluation of the BioBridge Scaffold as an Adjunct to Lymph Node Transplant for Upper Extremity Lymphedema Scientific Title

Purpose

To investigate the safety and effects (good and bad) of using an experimental device called a Biobridge scaffold during surgery to treat lymphedema.

Who is this for?

People who have completed breast cancer treatment at least three years ago, have no evidence of disease, and have been diagnosed with lymphedema. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT) </li> <li class="seamTextUnorderedListItem">BioBridge Collagen Matrix inserted into your body during surgery </li> </ul> Group 2: Standard of care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that may develop as a side effect of some breast cancer therapies. </li> <li class="seamTextUnorderedListItem">Lymphedema happens when there is a blockage in your lymphatic system (a part of your immune system) that stops the lymph fluid from draining well. The fluid buildup causes the abnormal swelling. </li> <li class="seamTextUnorderedListItem">The surgery used in this trial to help with your lymphedema is called a vascularized lymph node transfer.</li> <li class="seamTextUnorderedListItem">Your doctor will insert a Biobridge scaffold during your vascularized lymph node transfer. </li> <li class="seamTextUnorderedListItem">The Biobridge scaffold is made of collagen and may help lymph vessels grow around lymph blockages.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04606030' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/conditions-and-diseases/breast-cancer/breast-cancer-lymphedema-after-treatment' target='_blank'>Johns Hopkins Medicine: Breast Cancer, Lymphedema After Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://intermountainhealthcare.org/services/cancer-care/treatments-and-procedures/lymphedema-treatment/our-services/vascularized-lymph-node-transfer/' target='_blank'>Intermountain Healthcare: Vascularized Lymph Node Transfer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fibralignbio.com/biobridge-2/' target='_blank'>Fibralign Corporation Medical Device Information Page: Biobridge</a> </li></ul>

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: Coincides with surgery or routine care, then 1-2 visits every year for 5 years

PHASE: NA

NCT ID: NCT05505643

Cryoablation Compared to Lumpectomy for Women with Stage I HR+, HER2- Breast Cancer

COOL-IT: Cryoablation vs Lumpectomy in T1 Breast Cancers: A Randomized Controlled Trial With Safety Lead-in Scientific Title

Purpose

To compare the safety, effects (good and bad), and anti-cancer activity of cryoablation and lumpectomy.

Who is this for?

Women at least 50 years old with stage I hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who are not planning on receiving neoadjuvant (before surgery) chemotherapy. You must not have a BRCA1 or BRCA2 mutation. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation with Endocare(TM) SlimLine(TM) Cryoprobe</li> <li class="seamTextUnorderedListItem">MRI scan, after 6 months</li> <li class="seamTextUnorderedListItem">Mammogram, every year for 5 years</li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lumpectomy</li> <li class="seamTextUnorderedListItem">MRI scan, after 6 months</li> <li class="seamTextUnorderedListItem">Mammogram, every year for 5 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The standard approach (standard of care) for people with this kind of breast cancer is a lumpectomy. A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">Cryoablation is a method of killing a tumor by freezing it.</li> <li class="seamTextUnorderedListItem">Endocare(TM) SlimLine(TM) Cryoprobe is designed to deliver cold temperatures for cryoablation.</li> <li class="seamTextUnorderedListItem">If you are in group 1 and experience recurrence (cancer coming back), you may choose to receive a lumpectomy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05505643' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO

VISITS: At least 5 visits within 3 years

PHASE: NA

NCT ID: NCT05972343

Cryoablation for Breast Cancer

COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients: A Prospective Observational Registry Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of cryoablation.

Who is this for?

People with advanced (some stage III) or metastatic (stage IV) breast cancer, or people with stage I, stage II, or stage III breast cancer who refuse or are unable to receive surgery. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation, 1 time</li> <li class="seamTextUnorderedListItem">Imaging scans, 4 times in 3 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation is a procedure in which an extremely cold liquid or device is used to freeze and destroy cancer cells.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05972343' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cryoablation' target='_blank'>National Cancer Institute: Cryoablation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/cryotherapy' target='_blank'>Breastcancer.org: Cryotherapy</a> </li></ul>

NEAREST SITE: 1854 miles
AMITA Health Saint Joseph Chicago
Chicago,IL

VISITS: Coincides with surgery

PHASE: II

NCT ID: NCT05554211

Tranexamic Acid to Reduce Drainage After Bilateral Mastectomy

Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage Scientific Title

Purpose

To study the safety and ability of tranexamic acid to reduce drainage after a bilateral mastectomy.

Who is this for?

Women who are planning to receive a bilateral mastectomy to reduce their risk of developing breast cancer and women with DCIS, stage I, stage II, or some stage III breast cancer who are planning to receive a bilateral mastectomy. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tranexamic acid, by skin</li> <li class="seamTextUnorderedListItem">Gentamicin</li> </ul> Group 2: Standard Treatment <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo (saline) for tranexamic acid, by skin</li> <li class="seamTextUnorderedListItem">Gentamicin</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A bilateral mastectomy is surgery to remove both breasts.</li> <li class="seamTextUnorderedListItem">Women with a strong family history of breast cancer or a BRCA mutation may choose to undergo a bilateral mastectomy to reduce their risk of developing breast cancer.</li> <li class="seamTextUnorderedListItem">Drains help remove fluid build up in the area where the breast is removed.</li> <li class="seamTextUnorderedListItem">Tranexamic acid is an FDA approved drug that promotes blood clotting by preventing the breakdown of blood clots that your body naturally forms.</li> <li class="seamTextUnorderedListItem">Tranexamic acid is commonly used to control bleeding in a variety of surgeries and is available in injection or oral forms. However, because it is not currently FDA approved for use in elective breast surgery, this drug is considered experimental in this study. </li> <li class="seamTextUnorderedListItem">Gentamicin is an antibiotic used to prevent infection after surgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05554211' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://moffitt.org/cancers/breast-cancer/treatment/bilateral-mastectomy/' target='_blank'>Moffitt Cancer Center: Bilateral Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a612021.html' target='_blank'>Medline Plus: Tranexamic Acid</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verywellhealth.com/managing-your-surgical-drains-following-breast-surgery-4021630' target='_blank'>Verywell Health: Surgical Drains After Breast Surgery</a> </li></ul>

NEAREST SITE: 2139 miles
Emory University Hospital/Winship Cancer Institute
Atlanta,GA

VISITS: May require hospitalization

PHASE: NA

NCT ID: NCT04895592

Stereotactic Radiosurgery and Dexamethasone Before Surgery for Brain Metastasis

Preoperative Radiosurgery for Brain Metastases Planned for Surgical Resection: A Two Arm Pilot Study Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of stereotactic radiosurgery with dexamethasone before brain surgery.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis). You must have at least 1 brain tumor that has not been treated with radiation. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery, 1-3 sessions within 1-5 days</li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth or IV, up to 3 weeks</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Dexamethasone is an anti-inflammation medication used to prevent and treat side effects of some cancer treatments.</li> <li class="seamTextUnorderedListItem">You will receive either a low or high dose of dexamethasone.</li> <li class="seamTextUnorderedListItem">Giving stereotactic radiosurgery before surgery may reduce the risk of cancer coming back after surgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04895592' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 2175 miles
Cleveland Clinic Akron General, Case Comprehensive Cancer Center
Akron,OH

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT05825482

Savi Scout To Remove All Tumor Cells During Surgery for Stage 0-II Breast Cancer

Breast Margin Study: Routine Cavity Shave Margins Vs. Selective Margins Using Savi Scout® Scientific Title

Purpose

To study if the Savi Scout® device can help surgeons identify and remove all tumor cells during surgery.

Who is this for?

Women with stage 0 (DCIS), stage I, or stage II breast cancer who are planning to receive a partial mastectomy (lumpectomy). You must not have received chemotherapy. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Procedure to place Savi Scout® device, before surgery</li> <li class="seamTextUnorderedListItem">Surgery with standard of care margin removal using Savi Scout®</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Procedure to place Savi Scout® device, before surgery</li> <li class="seamTextUnorderedListItem">Surgery with selective margin removal using Savi Scout®</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Savi Scout® device helps surgeons identify tumors before surgery.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy. It is a standard of care (routine) procedure that removes the tumor and a rim of surrounding normal tissue (margins) while leaving as much normal breast tissue as possible.</li> <li class="seamTextUnorderedListItem">A margin that does not contain tumor cells is called a negative margin and tells the surgeon that the tumor has been removed. A positive margin contains tumor cells at or near the edge of the tissue removed.</li> <li class="seamTextUnorderedListItem">Selective margin removal means the surgeon may be better able to remove all tumor cells while reducing the amount of tissue removed.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05825482' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pennmedicine.org/cancer/types-of-cancer/breast-cancer/breast-cancer-treatment/lumpectomy/savi-scout' target='_blank'>Penn Medicine: Savi Scout®</a> </li></ul>

NEAREST SITE: 2193 miles
Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland,OH

VISITS: May require hospitalization

PHASE: I-II

NCT ID: NCT01891318

Stereotactic Radiosurgery Before Brain Surgery for Brain Metastasis

Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study Scientific Title

Purpose

To study the safety, effects (good and bad), best dose, and anti-cancer activity of stereotactic radiosurgery given before brain surgery.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis) and 1-4 brain tumors. You must have at least 1 brain tumor that has not been treated with radiation. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery focuses the x-rays directly to the tumor and cause less damage to the normal tissue in the brain.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01891318' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 2260 miles
Allegheny General Hospital
Pittsburgh,PA

VISITS: May require hospitalization

PHASE: NA

NCT ID: NCT05341739

Stereotactic Radiosurgery and Brain Surgery for Brain Metastasis

A Phase II Study of Pre-Operative Stereotactic Radiosurgery Followed by Surgical Resection for Brain Metastases Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of stereotactic radiosurgery given before brain surgery.

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CT and MRI scan</li> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery, 3 sessions within 3-6 days</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaire</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">A computed tomography (CT) scan produces body pictures created by x-ray energy.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by magnetic energy rather than x-ray energy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05341739' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 2371 miles
University of Virginia
Charlottesville,VA

VISITS: 1-2 visits within 8 days

PHASE: I

NCT ID: NCT04796220

Thermal Treatment and Chemotherapy Before Surgery for Stage I-III Breast Cancer

Focused Ultrasound With Low-Dose Gemcitabine to Augment Immune Control of Early Stage Breast Cancer Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of EchoPulse ultrasound ablation and gemcitabine (Gemzar®) chemotherapy alone or together before surgery (neoadjuvant).

Who is this for?

People with newly diagnosed stage I, stage II, or stage III breast cancer who have not yet received treatment. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, 1 time</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation of tumor, 1 time</li> </ul> Group 3 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, 1 time</li> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation of tumor, 1 time</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation applies high-intensity focused ultrasound waves to a tumor, which ablates (heats) the tumor tissue to kill cancer cells.</li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®) is a type of chemotherapy that kills cancer cells.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment, like chemotherapy, before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04796220' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.theraclion.com/products/echopulse/' target='_blank'>Theraclion: EchoPulse Ultrasound Ablation</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/treatments/16541-hifu-high-intensity-focused-ultrasound' target='_blank'>Cleveland Clinic: High-Intensity Focused Ultrasound</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/drugs/gemzar' target='_blank'>Breastcancer.org: Gemcitabine (Gemzar®)</a> </li></ul>

NEAREST SITE: 2375 miles
University of Virginia Medical Center
Charlottesville,VA

VISITS: Coincides with surgery

PHASE: III-IV

NCT ID: NCT06428682

Tranexamic Acid to Reduce Blood Loss During Breast Reconstruction Surgery

Role of Intravenous Tranexamic Acid Use in Patients Undergoing Breast Free Flap Reconstruction: Randomized Controlled Trial Scientific Title

Purpose

To study if the drug, tranexamic acid (TXA), reduces the need for blood transfusions during breast reconstruction surgery.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who are planning to receive breast reconstruction surgery at UVA Medical Center. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: TXA During Surgery <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tranexamic acid (TXA), by IV during surgery</li> </ul> Group 2: No TXA During Surgery <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for tranexamic acid (TXA), by IV during surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tranexamic acid (TXA) is a drug used to help blood clotting and reduce blood loss during some types of surgery.</li> <li class="seamTextUnorderedListItem">A blood transfusion is when donated blood is given to you.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06428682' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/tranexamic-acid-oral-route/description/drg-20073517' target='_blank'>Mayo Clinic: Tranexamic Acid</a> </li></ul>

NEAREST SITE: 2383 miles
Mayo Clinic in Florida
Jacksonville,FL

VISITS: Coincides with surgery

PHASE: II

NCT ID: NCT06153836

Nerve Reconstruction to Maintain Feeling in the Nipple After Mastectomy for Women with Stage 0-II Breast Cancer

Randomized Feasibility Study to Determine the Feasibility of Neurotization of the Nipple Areolar Complex at the Time of Nipple Sparing Mastectomy and Prosthetic Based Reconstruction Scientific Title

Purpose

To study if a surgical technique using a nerve graft, also called nerve reconstruction, will maintain feeling in the nipple after a nipple-sparing mastectomy.

Who is this for?

Women with stage 0 (DCIS), stage I, or stage II node negative breast cancer who are planning to receive a nipple-sparing mastectomy and have not had previous breast radiation, breast reduction, or breast augmentation. You must have a bra cup size of A to C. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care nipple-sparing mastectomy</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care nipple-sparing mastectomy with nerve graft</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A mastectomy is surgery to remove the breast.</li> <li class="seamTextUnorderedListItem">Nerve damage can occur during a mastectomy. When nerves are damaged, you may feel numbness, also known as loss of sensation.</li> <li class="seamTextUnorderedListItem">A nerve graft, also called nerve reconstruction, replaces nerves damaged during the mastectomy.</li> <li class="seamTextUnorderedListItem">This nerve graft surgery can be performed during nipple-sparing mastectomy and reconstruction and may maintain feeling in the nipple and improve quality of life.</li> <li class="seamTextUnorderedListItem">Node negative means cancer has not spread to your lymph nodes.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06153836' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nebraskamed.com/cancer/breast-cancer/breast-reconstruction/mastectomies-and-nipples-what-are-the-options-for-breast-reconstruction' target='_blank'>University of Nebraska: Restoring Nipple Sensation After Mastectomy</a> </li></ul>

NEAREST SITE: 2383 miles
Mayo Clinic
Jacksonville,FL

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT04742231

Measuring Hand Strength During Brain Surgery to Predict How the Craniotomy Will Affect Motor Skills

Use of Handheld Dynamometer as a Novel Tool to Assess Motor Function During Awake Craniotomy for Brain Lesions Located Within or Adjacent to the Motor Cortex: A Single-Center Pilot Study Scientific Title

Purpose

To study the safety and reliability of measuring hand strength during an awake craniotomy to monitor how the surgery will affect your motor skills.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastases) and who will have an awake craniotomy at the Mayo Clinic in Jacksonville, Florida. Full eligibility criteria

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Your hand strength will be measured during surgery with a handheld device called a K-FORCE Grip dynamometer®.
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A craniotomy is a type of brain surgery. The surgeon will remove part of your skull (cranium) to access your brain to remove the tumors. </li> <li class="seamTextUnorderedListItem">You will be awake during the craniotomy so that you can use a handheld device to monitor how the surgery is affecting your motor skills. </li> <li class="seamTextUnorderedListItem">Motor skills are body movements and include walking, hand movements (like writing), and other types of movement. </li> <li class="seamTextUnorderedListItem">K-FORCE Grip® is a handheld dynamometer. A dynamometer is a machine that is held in the hand and can measure the strength of your grip. </li> <li class="seamTextUnorderedListItem">Researchers believe measuring grip strength may predict how removing tumors will affect motor skills.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04742231' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/craniotomy' target='_blank'>Johns Hopkins Medicine: Craniotomy?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/tests-procedures/awake-brain-surgery/about/pac-20384913' target='_blank'>Mayo Clinic: Awake Brain Surgery</a> </li><li class='seamTextUnorderedListItem'><a href='https://k-invent.com/produit/k-force-grip/' target='_blank'>Kinvent Device Information Page: KForce Grip</a> </li></ul>

NEAREST SITE: 2395 miles
Moffitt Cancer Center
Tampa,FL

VISITS: 4 visits over 1 week including surgery; may require hospitalization

PHASE: II

NCT ID: NCT05267587

Stereotactic Radiosurgery and Craniotomy for Brain Metastasis

Pre-operative Hypofractionated Stereotactic Radiosurgery for Resectable Brain Metastases Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of stereotactic radiosurgery before brain surgery.

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery, 3 days</li> </ul> followed 5 days later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Craniotomy to remove tumor</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy. </li> <li class="seamTextUnorderedListItem">A craniotomy is a type of brain surgery. The surgeon will remove part of your skull (cranium) to access your brain to remove the tumors.</li> <li class="seamTextUnorderedListItem">If there are additional brain metastases, they will also be treated with stereotactic radiosurgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05267587' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD

VISITS: Requires hospitalization

PHASE: NA

NCT ID: NCT02639325

Brain Surgery for Brain Metastasis and Tumor Related Epilepsy

Tumor Related Epilepsy Scientific Title

Purpose

To study if brain surgery reduces the number of seizures and to see how surgery affects seizures.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis). You must have no more than one brain tumor and have experienced at least one seizure associated with the tumor. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Requires hospitalization for at least one week</li> <li class="seamTextUnorderedListItem">Questionnaires, cognitive assessments, and seizure diary</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. </li> <li class="seamTextUnorderedListItem">Researchers think surgery may improve outcomes for people with tumor-related epilepsy by stopping seizures or reducing the number of seizures.</li> <li class="seamTextUnorderedListItem">Cognitive assessments study your cognition, which is your ability to think.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02639325' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/brain-metastasis/' target='_blank'>MBCBrainMets.org: About Brain Metastasis</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/treatments-brain-metastasis/#toggle-id-7' target='_blank'>MBCBrainMets.org: Brain Metastasis Treatments</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/research-news/brain-mets/' target='_blank'>Metastastic Trial Talk: Treating Breast Cancer Brain Mets</a> </li></ul>

NEAREST SITE: 2440 miles
Central Maryland Oncology Center
Columbia,MD

VISITS: 1 visit before surgery

PHASE: NA

NCT ID: NCT04234386

One Dose of Radiation Therapy Before Surgery for Women with Stage I or Stage II, ER+, HER2- Breast Cancer

Phase Ib Dose Escalation of Single-Fraction Preoperative Stereotactic Partial-Breast Irradiation for Early-Stage Breast Cancer Scientific Title

Purpose

To study the anti-cancer activity, best dose and side effects of giving stereotactic radiation therapy one time before surgery.

Who is this for?

Women with stage I or stage II ER positive (ER+), HER2 negative (HER2-), node-negative breast cancer who are age 45 or older and whose tumor is no larger than 3 cm. Full eligibility criteria

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You will receive the following before surgery: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic partial breast radiation therapy, by GammaPod, one time</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation therapy uses fewer, more-targeted, higher-dose treatments than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">This method helps keep the healthy breast tissue from being damaged by the radiation therapy.</li> <li class="seamTextUnorderedListItem">GammaPod is the machine used in this study to give the stereotactic radiation therapy. It is approved for use during a lumpectomy for early stage breast cancer, but its use in this trial is considered experimental.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04234386' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.umms.org/ummc/pros/physician-briefs/cancer/breast/gammapod-less-invasive-radiotherapy-device-early-stage' target='_blank'>University of Maryland Medical Center: GammaPod</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy/expectations' target='_blank'>Breastcancer.org: Lumpectomy, What to Expect</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825433/' target='_blank'>Journal Article: Use of Preoperative Radiation Therapy in Early-stage and Locally Advanced Breast Cancer</a> </li></ul>

NEAREST SITE: 2453 miles
Johns Hopkins Hospital
Baltimore,MD

VISITS: Coincides with surgery, then 6 visits within 1.5 years

PHASE: NA

NCT ID: NCT04533373

Nerve Repair to Restore Sensation During Breast Reconstruction Surgery

The Effect of DIEP Flap Neurotization on Sensory Restoration After Breast Reconstruction Scientific Title

Purpose

To study the ability of nerve repair during reconstruction surgery to restore sensation.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer or women at risk of breast cancer who have received or are planning to receive a mastectomy and reconstruction. You must be receiving your care at Johns Hopkins. You must not have received radiation. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nerve repair during reconstruction surgery</li> <li class="seamTextUnorderedListItem">Breast sensation measurements, 5 times within 1.5 years</li> <li class="seamTextUnorderedListItem">Questionnaires, 5 times within 1.5 years</li> </ul> Group 2: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No nerve repair during reconstruction surgery</li> <li class="seamTextUnorderedListItem">Breast sensation measurements, 5 times within 1.5 years</li> <li class="seamTextUnorderedListItem">Questionnaires, 5 times within 1.5 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sensory nerves, which are responsible for sensation from skin, are cut during breast surgery, and sensation is lost to the area supplied by the nerve.</li> <li class="seamTextUnorderedListItem">Achieving breast sensation with nerve repair is a goal of reconstructive surgery after mastectomy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04533373' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2519 miles
Thomas Jefferson University Hospital
Philadelphia,PA

VISITS: 5 visits

PHASE: NA

NCT ID: NCT04959474

Reducing Calories During Radiation Therapy for DCIS or Stage I-III Breast Cancer

SABR-CaRe: A Phase II Randomized Trial of Pre-Operative Stereotactic Ablative Radiation Therapy (SABR) With and Without Caloric Restriction for Early Stage Breast Cancer Scientific Title

Purpose

To determine if neoadjuvant (before surgery) calorie restriction during radiation therapy decreases the size of tumor tissue, compared to radiation therapy alone.

Who is this for?

People age 40 and older with DCIS, stage I, stage II, or stage III node negative breast cancer or age 50 and older if you have triple negative (ER-, PR-, HER2-) breast cancer. You must have not yet received chemotherapy, radiation, or surgery. Full eligibility criteria

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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic ablative radiation therapy (SABR) is a highly focused radiation treatment that gives an intense dose of radiation concentrated on a tumor, while limiting the dose to the surrounding organ.</li> <li class="seamTextUnorderedListItem">Giving SABR before surgery may make the tumor smaller.</li> <li class="seamTextUnorderedListItem">Adding dietary restriction to radiation therapy may help increase the effectiveness of the radiation and decrease the spread of the cancer to other places in the body.</li> <li class="seamTextUnorderedListItem">The reduced calorie diet consists of reducing your calorie intake by 25%.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04959474' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://stanfordhealthcare.org/medical-treatments/s/stereotactic-body-radiation-therapy.html#:~:text=Stereotactic%20ablative%20radiotherapy%20(SABR)%2C,dose%20to%20the%20surrounding%20organs.' target='_blank'>Stanford: Stereotactic Ablative Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.jefferson.edu/university/jmc/departments/radiation_oncology/news/07212014.html' target='_blank'>Thomas Jefferson University: Calorie Restriction and Breast Cancer</a> </li></ul>

NEAREST SITE: 2537 miles
Robert Wood Johnson University Hospital Somerset
Somerville,NJ

VISITS: 4 visits before surgery; 5 visits per week, for 6 weeks after surgery, over 4 months

PHASE: NA

NCT ID: NCT04871516

Radiation Therapy Before and After Surgery for Stage I-III, Node-Negative Breast Cancer

A Single Center Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients Scientific Title

Purpose

To study the safety, anti-cancer activity, and cosmetic outcomes of giving radiation therapy to the breast before and after surgery.

Who is this for?

People with stage I, stage II, or stage III node-negative breast cancer. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy, 4 times before surgery</li> <li class="seamTextUnorderedListItem">followed by breast surgery</li> <li class="seamTextUnorderedListItem">followed by whole breast radiation therapy, 5 days a week, for 4 to 6 weeks</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to kill tumor cells.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04871516' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/treatment/type/radiation-therapy/' target='_blank'>Susan G. Komen: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://moffitt.org/newsroom/press-release-archive/radiation-therapy-prior-to-surgery-reduces-the-risk-of-secondary-tumors-in-early-stage-breast-cancer-patients/' target='_blank'>Moffit Cancer Center: Radiation Therapy Prior to Surgery</a> </li></ul>

NEAREST SITE: 2539 miles
Memorial Sloan Kettering at Basking Ridge (Consent Only)
Basking Ridge,NJ

VISITS: Coincides with surgery

PHASE: II

NCT ID: NCT04690348

Radiation During Surgery for Recurrent Brain Metastases

Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study Scientific Title

Purpose

To compare the safety, anti-cancer activity, and side effects of brachytherapy (a type of radiation that occurs during brain surgery) with the usual approach of brain surgery without brachytherapy.

Who is this for?

People with metastatic (stage IV) breast cancer with brain metastases (cancer that has spread to the brain) that has already been treated with radiation. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery</li> </ul> Group 2: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery </li> <li class="seamTextUnorderedListItem">Cesium 131 (Cs131) brachytherapy (radiation), during surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brachytherapy is a type of internal radiation therapy. It works by placing a radioactive material directly inside or next to the tumor. </li> <li class="seamTextUnorderedListItem">It takes less time than traditional radiation and uses a higher total radiation dose to treat a smaller area.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04690348' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/types/radiation-therapy/brachytherapy#:~:text=Brachytherapy%20is%20a%20type%20of%20internal%20radiation%20therapy%20in%20which,specific%20part%20of%20your%20body.' target='_blank'>Cancer.gov: Brachytherapy</a> </li></ul>

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Consent and follow-up only)
Basking Ridge,NJ

VISITS: Coincides with surgery

PHASE: III

NCT ID: NCT03351348

Bupivacaine to Reduce Pain After Mastectomy for DCIS and Stage I-III Breast Cancer

Double Blind, Randomized, Placebo Controlled Trial of Locally Instilled Bupivacaine in the Surgical Bed After Unilateral Mastectomy Without Reconstruction Scientific Title

Purpose

To study the ability of bupivacaine with standard of care pain medications to reduce pain after a mastectomy.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or some stage III breast cancer planning to receive a unilateral mastectomy without immediate reconstruction at Memorial Sloan Kettering Cancer Center. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for bupivacaine, by surgical drain</li> <li class="seamTextUnorderedListItem">Standard of care pain medications</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bupivacaine, by surgical drain</li> <li class="seamTextUnorderedListItem">Standard of care pain medications</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires, 2 times within 1 year</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bupivacaine is a FDA-approved numbing medicine used for some surgical and dental procedures.</li> <li class="seamTextUnorderedListItem">The addition of bupivacaine to the surgical wound site with standard of care pain medications could better manage your pain immediately after surgery and reduce the amount of opioid medications taken after surgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03351348' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/bupivacaine-injection-route/description/drg-20406723#:~:text=Bupivacaine%20injection%20is%20used%20to,It%20is%20a%20local%20anesthetic.' target='_blank'>Mayo Clinic: Bupivacaine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/tests-procedures/mastectomy/expert-answers/pain-after-breast-surgery/faq-20058049' target='_blank'>Mayo Clinic: Pain After Breast Surgery</a> </li></ul>

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Cancer Center (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT05892068

Tucatinib Before Surgery for Metastatic HER2+ Breast Cancer That Has Spread to the Brain

Window of Opportunity Analysis of Pre-Operative Tucatinib for Surgically Resected HER2+ Brain Metastases: Understanding Mechanisms of Resistance Scientific Title

Purpose

To study how the brain absorbs, distributes, and gets rid of tucatinib (Tukysa®) in people who have HER2+ breast cancer that has spread to the brain, and to learn more about how cancer cells develop resistance to treatment.

Who is this for?

Women with metastatic (stage IV) HER2+ breast cancer that has spread to the brain (brain metastases) and who are planning to receive surgery to remove the cancer. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa®), by mouth, daily for 5 days</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa) is a type of HER2 targeting therapy called a kinase inhibitor. It is able to cross the blood-brain barrier. This means it works against cancer cells that have spread to the brain. Tucatinib is approved for use in people with metastatic, HER2+ breast cancer when it is taken with trastuzumab and capecitabine. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05892068' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted-therapy/tukysa' target='_blank'>Breastcancer.org: Tucatinib</a> </li></ul>

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: May require hospitalization

PHASE: I

NCT ID: NCT05412225

Radiation Before Mastectomy with Immediate Reconstruction for Stage III Breast Cancer

Feasibility of Preoperative Radiotherapy in T4 Breast Cancer Patients Who Are Responders to Neoadjuvant Chemotherapy to Allow for Immediate Reconstruction: A Prospective Study Scientific Title

Purpose

To study the safety and effects (good and bad) of an alternative treatment approach: radiation followed by mastectomy with immediate reconstruction.

Who is this for?

Women with advanced (some stage III) breast cancer who have responded to neoadjuvant (before surgery) chemotherapy and are planning to undergo mastectomy with immediate reconstruction. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI scan</li> <li class="seamTextUnorderedListItem">Biopsy</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation</li> </ul> followed 2-6 weeks later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Total mastectomy with immediate autologous reconstruction</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies. </li> <li class="seamTextUnorderedListItem">Mastectomy is a type of surgery to remove the entire breast.</li> <li class="seamTextUnorderedListItem">Immediate autologous reconstruction is breast reconstruction surgery immediately following your mastectomy. The surgeon will take tissue from another part of your body and use it to re-create your breast.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy. The MRI scan will help guide your biopsy before radiation and surgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05412225' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/autologous-flap' target='_blank'>Breastcancer.org: Immediate Autologous Reconstruction</a> </li></ul>

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Cancer Center at Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: Please contact research site

PHASE: I

NCT ID: NCT06246968

Pembrolizumab and Cryoablation for Advanced Triple Negative Breast Cancer

Does Cryoablation Boost Immune Response Improving the Benefits of Pembrolizumab in Patients With Metastatic or Locally Advanced Triple Negative Breast Cancer? Scientific Title

Purpose

To study the safety, effects (good and bad), and anti-cancer activity of pembrolizumab (Keytruda®) PD-1 inhibitor with cryoablation, an experimental alternative to surgery.

Who is this for?

People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who have received 0-2 lines of therapy and are planning to receive pembrolizumab (Keytruda®). Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®)</li> <li class="seamTextUnorderedListItem">Cryoablation</li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor, which is a type of immune checkpoint inhibitor. Blocking PD-1 may allow the body's immune system to detect and fight cancer cells.</li> <li class="seamTextUnorderedListItem">Cryoablation is a procedure in which an extremely cold liquid or device is used to freeze and destroy cancer cells.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06246968' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2567 miles
Weill Cornell Medicine
New York,NY

VISITS: 5 visits over 1-2 weeks

PHASE: II

NCT ID: NCT04371913

Radiation Therapy Instead of Surgery for Local Recurrence in Women 50+

Personalized Second Chance Breast Conservation (PSCBC): A Two Center Prospective Phase II Clinical Study Scientific Title

Purpose

To study the safety and anti-cancer activity of treating a local recurrence (when your cancer returns to your breast) with radiation therapy instead of a mastectomy.

Who is this for?

Women, 50 or older, with stage I or stage II locally recurrent breast cancer who had received a lumpectomy (breast conserving surgery) and radiation therapy for their first diagnosis. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Accelerated Partial Breast Radiation (APBI), 5 times, over 1-2 weeks</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Many women receive a lumpectomy (breast conserving surgery) and radiation therapy for early-stage breast cancer.</li> <li class="seamTextUnorderedListItem">It is called a local recurrence if your breast cancer returns to the breast that has already received surgery and radiation therapy.</li> <li class="seamTextUnorderedListItem">A mastectomy is the standard of care for treating a local recurrence.</li> <li class="seamTextUnorderedListItem">This trial is studying if it is safe to use radiation therapy instead of a mastectomy for a local recurrence.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04371913' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/diagnosis-treatment/drc-20377141' target='_blank'>Mayo Clinic: Recurrent Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/radiation-for-breast-cancer.html' target='_blank'>American Cancer Society: Radiation for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-fraction-radiation-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Accelerated-Fraction Radiation Therapy</a> </li></ul>

NEAREST SITE: 2569 miles
Columbia University Irving Medical Center/NYP
New York,NY

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05219695

Thermal Treatment for Stage I Breast Cancer and Benign Breast Tumors

Medical Imaging and Thermal Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI) Scientific Title

Purpose

To study the effects of harmonic motion imaging (HMI) and focused ultrasound (FUS) ablation before surgery (neoadjuvant).

Who is this for?

Women with a benign breast tumor or some stage I breast cancer who have not yet received surgery or radiation. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Harmonic motion imaging (HMI) scan, 2 times</li> <li class="seamTextUnorderedListItem">Focus ultrasound (FUS) ablation of tumor</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Harmonic motion imaging (HMI) is a type of scan that can look for changes in tissue before and after focused ultrasound (FUS) ablation.</li> <li class="seamTextUnorderedListItem">Focused ultrasound (FUS) ablation applies high-intensity focused ultrasound waves to a tumor, which ablates (heats) the tumor tissue to kill cancer cells.</li> <li class="seamTextUnorderedListItem">The main advantage of focused ultrasound (FUS) ablation is that it avoids surgery. Without surgery, recovery from the procedure is faster with less pain, and cosmetological results may be improved.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li> <li class="seamTextUnorderedListItem">The two most common types of benign breast lumps are cysts and fibroadenomas.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05219695' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ueil.bme.columbia.edu/research-projects/harmonic-motion-imaging' target='_blank'>Columbia University: Harmonic Motion Imaging</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/other/high-intensity-focused-ultrasound-hifu' target='_blank'>Cancer Research UK: High-Intensity Focused Ultrasound</a> </li></ul>

NEAREST SITE: 2591 miles
University of Miami
Miami,FL

VISITS: 5 days, over 2 weeks

PHASE: NA

NCT ID: NCT04360330

Stereotactic Radiation Therapy Before Lumpectomy for Women 50+ with Stage I, HR+, HER2- Breast Cancer

Phase I Study to Evaluate the Safety and Feasibility of Preoperative Ablative Breast Radiotherapy (SABER) for Selected Early Stage Breast Cancer (SABER) Scientific Title

Purpose

This trial will study the safety of giving stereotactic radiation therapy before surgery. Stereotactic radiation therapy delivers a higher targeted dose of radiation in fewer sessions than standard radiation therapy.

Who is this for?

Woman, 50 or older, with stage I, hormone positive (ER+ and PR+), HER2 negative (HER2-) breast cancer who have not yet had surgery. Full eligibility criteria

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Before surgery, you will receive: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic Ablative Breast Radiotherapy (SABER), for 5 days, over 2 weeks</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation therapy delivers a higher targeted dose of radiation in fewer sessions than standard radiation therapy.</li> <li class="seamTextUnorderedListItem">This trial is looking at the effects of giving stereotactic radiation before surgery. </li> <li class="seamTextUnorderedListItem">Typically, this type of radiation therapy is given after surgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04360330' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nationalbreastcancer.org/breast-cancer-radiation-therapy' target='_blank'>National Breast Cancer Foundation: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://stanfordhealthcare.org/medical-treatments/s/stereotactic-body-radiation-therapy.html' target='_blank'>Standford Healthcare: Stereotactic Ablative Radiotherapy (SABR/SBRT)</a> </li></ul>

NEAREST SITE: 2591 miles
University of Miami
Miami,FL

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT04998682

Removing Lymph Nodes During Surgery for Stage III Breast Cancer

TAD: Prospective Evaluation of Targeted Axillary Dissection After Neoadjuvant Systemic Therapy in Patients With Breast Cancer With Advanced Nodal Disease at Diagnosis Scientific Title

Purpose

To determine if examining axillary (underarm/armpit) lymph nodes provides information to determine if fewer lymph nodes can be removed during surgery.

Who is this for?

People with some stage III node positive breast cancer who have received neoadjuvant (before surgery) chemotherapy and are planning to receive surgery. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Removal of axillary lymph nodes during surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The surgery that examines and/or removes lymph nodes from your underarm/armpit area is called a targeted axillary dissection (TAD), sometimes also called an axillary lymph node dissection (ALND). </li> <li class="seamTextUnorderedListItem">During surgery, a blue dye will be used to see your lymph nodes and the lymphatic channels that drain your arm.</li> <li class="seamTextUnorderedListItem">Node positive means cancer has spread to your lymph nodes.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04998682' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph-node-removal/axillary-dissection' target='_blank'>Breastcancer.org: Axillary Lymph Node Dissection</a> </li></ul>

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: 6 visits within 2 years

PHASE: NA

NCT ID: NCT04636710

Imaging to Identify Lymph Nodes and Limit Lymph Node Removal for Women with Stage III Inflammatory Breast Cancer

Refining Local-Regional Therapy for Inflammatory Breast Cancer (IBC) Scientific Title

Purpose

To identify the first lymph nodes that drain the breast to limit lymph node removal and reduce the risk of lymphedema in women with inflammatory breast cancer.

Who is this for?

Women with stage III inflammatory breast cancer who have not yet received treatment. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphoscintigraphy with radioactive dye, by injection, 2 times</li> <li class="seamTextUnorderedListItem">Lymph node surgery</li> <li class="seamTextUnorderedListItem">Questionnaires, 6 times within 2 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A lymphoscintigraphy, also called sentinel lymph node mapping, is an imaging procedure used to identify how lymph nodes drain.</li> <li class="seamTextUnorderedListItem">It is used to evaluate if breast cancer has spread to the axillary lymph nodes (lymph nodes under the arm) in non-inflammatory breast cancer.</li> <li class="seamTextUnorderedListItem">In non-inflammatory breast cancer, these lymph nodes are tested first, and if they are free of cancer, additional lymph nodes are not removed. </li> <li class="seamTextUnorderedListItem">By safely limiting lymph node removal, the likelihood of developing lymphedema (arm swelling) has been reduced in people with non-inflammatory breast cancer.</li> <li class="seamTextUnorderedListItem">It is not known whether lymphoscintigraphy can safely reduce lymph node removal and lymphedema in people with inflammatory breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04636710' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT04033497

MRI-Based Imaging Technique to Distinguish Recurrent Brain Metastases from Radiation Damage

Treatment Response Assessment Maps (TRAMs) in the Delineation of Radiation Necrosis From Tumor Progression After Stereotactic Radiation in Patients With Brain Metastases: A Prospective Study Scientific Title

Purpose

To study whether Treatment Response Assessment Maps, a brain imaging technique, can help distinguish between a metastatic recurrence and tissue damage from prior radiation.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastases). Participants must have had a metastatic recurrence at least 4 months after radiation to the same site in the brain and planning to undergo surgery. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain imaging by MRI and Treatment Assessment Maps followed by</li> <li class="seamTextUnorderedListItem">Brain surgery to remove suspected recurrence of brain metastasis</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Treatment Response Assessment Maps is an MRI-based imaging technique that may be able to distinguish recurrent brain metastases from radiation-damaged, but non-cancerous brain tissue.</li> <li class="seamTextUnorderedListItem">This technique may allow future patients to avoid unnecessary surgery.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04033497' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>