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Find Breast Cancer Clinical Trials That Are Right For You
The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.
Use the search box and filters to find a trial that’s right for you.
Currently viewing trials
(Last updated: May 08, 2024)
Brain Mets
BRCA1/2 (inherited)
Chemotherapy
Hormone Therapy
Leptomeningeal Disease
Radiation Oncology
Surgery
Surgery: Reconstruction
Targeted Therapy: All
Targeted Therapy: ADC
Targeted Therapy: Anti-HER2 Therapy
Targeted Therapy: CDK Inhibitors
Targeted Therapy: PARP Inhibitors
Targeted Therapy: Tumor Mutations
Targeted Therapy: Other Targeted Therapy
Vaccines and Immunotherapy
Other Treatment
Activities
Complementary and Integrative Medicine
Decision Support
Diagnosing Breast Cancer
Genetics/Family History
Having Children
Healthy/High Risk
Imaging
Lymphedema
Managing Side Effects
No Travel Required
Predicting Response to Treatment
Preventing Breast Cancer
Preventing Recurrence
Support/Education
Surveys/Interviews/Registries
AKT
ALK
AR
BARD1
BRCA1/2 (tumor)
BRIP1
CD205
CD70
CHEK2 or CHEK1
dMMR/MSI-H
ESR1
FGFR
HER2/ERBB2
HLA
MET or C-Met
NTRK
PALB2
PIK3CA or PI3K
PTEN
RAD51
RAF (including BRAF)
RAS (KRAS or NRAS)
RB
ROS1
TP53
NEAREST SITE: 3 miles
UCSF Medical Center at Mission Bay
San Francisco,CA
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT05456373
Device to Detect Positive Margins During Lumpectomy
Intraoperative Use of ClearEdge Device in Breast Conserving Surgery Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care assessment of margins during surgery</li> <li class="seamTextUnorderedListItem">ClearEdge tissue imaging device</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care assessment of margins during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The ClearEdge tissue imaging device uses a new technology to help the surgeon detect tissue abnormalities during surgery and identify cancer cells that would have been left behind (positive margins).</li> <li class="seamTextUnorderedListItem">This may allow the surgeon to remove all cancer cells during surgery and avoid cancer recurrence or the need to repeat surgery.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy. It is a standard of care (routine) procedure that removes the tumor and a rim of surrounding normal tissue (margins) while leaving as much normal breast tissue as possible.</li> <li class="seamTextUnorderedListItem">A margin that does not contain tumor cells is called a negative margin and tells the surgeon that the tumor has been removed. A positive margin contains tumor cells at or near the edge of the tissue removed.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05456373' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy' target='_blank'>Breastcancer.org: Lumpectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/margin' target='_blank'>National Cancer Institute: Clear Margins</a> </li><li class='seamTextUnorderedListItem'><a href='https://lsbiopath.com/patient/' target='_blank'>LSBiopath: ClearEdge Device Information Page</a> </li></ul>
NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA
VISITS: Coincides with surgery
PHASE: II
NCT ID: NCT05020574
Impact of Antibiotics on Infection and the Microbiome in People Receiving a Mastectomy
Microbiome and Association With Implant Infections: Investigating the Impact of Antibiotics on the Gut and Breast Microbiomes Post-mastectomy With Implant-based Breast Reconstruction Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, before and during surgery</li> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, daily for at least 7 days after surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) antibiotic, before and during surgery</li> <li class="seamTextUnorderedListItem">No antibiotics after surgery (unless infection occurs)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A mastectomy is surgery to remove a breast.</li> <li class="seamTextUnorderedListItem">Women with a strong family history of breast cancer or a BRCA mutation may choose to undergo a mastectomy to reduce their risk of developing breast cancer.</li> <li class="seamTextUnorderedListItem">Cephalexin (Keflex®) is an antibiotic used to prevent infection after surgery.</li> <li class="seamTextUnorderedListItem">The microbiome consists of the many bacteria, viruses, and fungi found on your body.</li> <li class="seamTextUnorderedListItem">The harmful bacteria cause disease such as infection, and the beneficial bacteria help keep you healthy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05020574' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a682733.html' target='_blank'>MedlinePlus: Cephalexin (Keflex®)</a> </li></ul>
NEAREST SITE: 6 miles
Cedars-Sinai
Los Angeles,CA
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT05720039
Nipple Sparing Mastectomy with da Vinci SP Surgical System for Women with Stage I-III Breast Cancer
A Prospective, Multicenter Randomized Controlled Trial(RCT) of the da Vinci® SPâ„¢ Surgical System vs Open Surgery in Nipple Sparing Mastectomy (NSM) Procedures Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Robotic-assisted nipple sparing mastectomy with da Vinci single port (SP) Surgical System</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Open nipple sparing mastectomy</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A mastectomy is surgery to remove a breast.</li> <li class="seamTextUnorderedListItem">A nipple sparing mastectomy (NSM) leaves most of the healthy breast skin, including the nipple.</li> <li class="seamTextUnorderedListItem">The da Vinci single port (SP) Surgical System is an experimental surgery system designed for surgeons to perform minimally invasive surgery, such as nipple sparing mastectomy.</li> <li class="seamTextUnorderedListItem"> Your surgeon performs the surgery using the da Vinci SP Surgical System.</li> <li class="seamTextUnorderedListItem">The da Vinci SP Surgical System is approved for use during other surgeries.</li> <li class="seamTextUnorderedListItem">Robotic-assisted NSM with da Vinci SP Surgical System may be less invasive than standard of care open NSM.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05720039' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.intuitive.com/en-us/patients/da-vinci-robotic-surgery/about-the-systems' target='_blank'>Intuitive Surgical Device Information Page: About the Da Vinci Surgical System</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cedars-sinai.org/health-library/diseases-and-conditions/n/nipple-sparing-mastectomy.html' target='_blank'>Cedars-Sinai: Nipple Sparing Mastectomy</a> </li></ul>
NEAREST SITE: 74 miles
University of California, Davis
Sacramento,CA
VISITS: Number of visits unavailable
PHASE: NA
NCT ID: NCT06103669
Adding Radiation to Treatment for People with Metastatic Oligoprogressive Breast Cancer
Locally ablatiVe therApy in oLigO-pRogressive sOlid tUmorS (VALOROUS) Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation or interventional radiology ablation</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">Interventional radiology ablation uses heat or cold to kill cancer cells.</li> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Oligoprogressive disease refers to progression of only a few sites of metastasis.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06103669' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://studypages.com/en/s/a-study-of-ablative-therapy-in-people-with-progressive-solid-tumors-valorous-278307/?ref=gallery' target='_blank'>University of California, Davis: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.columbiaradiology.org/patients/services/interventional-radiology/tumor-ablation' target='_blank'>Columbia University: Interventional Radiology Ablation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/treatment/radiotherapy/external/types/stereotactic-body-radiotherapy-sbrt' target='_blank'>Cancer Research UK: Stereotactic Radiotherapy</a> </li></ul>
NEAREST SITE: 339 miles
Providence Saint John's Hospital
Santa Monica,CA
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT05289466
Intraoperative Radiotherapy During Partial Mastectomy for Women Ages 50+ with Recurrent DCIS or Stage I-III Breast Cancer
Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT), 1 time</li> <li class="seamTextUnorderedListItem">Partial mastectomy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraoperative radiotherapy (IORT) is radiation given at the time of a partial mastectomy.</li> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">A partial mastectomy is surgery to remove part of the breast and is sometimes called a lumpectomy.</li> <li class="seamTextUnorderedListItem">Node negative means cancer has not spread to your lymph nodes.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with lobular breast cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05289466' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy/intraoperative' target='_blank'>Breastcancer.org: Intraoperative Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/oncoplastic-lumpectomy' target='_blank'>Breastcancer.org: Partial Mastectomy</a> </li></ul>
NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA
VISITS: May require hospitalization
PHASE: III
NCT ID: NCT04365374
Gamma Tile Surgically Targeted Radiation Therapy after Brain Surgery for Brain Metastasis
A Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT) Versus Surgically Targeted Radiation Therapy (STaRT) With Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors. Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove tumor and implant Gamma Tile device</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gamma Tile Surgically Targeted Radiation Therapy (STaRT)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove tumor</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognitive testing</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gamma Tile Surgically Targeted Radiation Therapy (STaRT) is a FDA-cleared radiation therapy.</li> <li class="seamTextUnorderedListItem">Gamma Tile is a device implanted during surgery that delivers radiation directly to the tumor, called Surgically Targeted Radiation Therapy (STaRT).</li> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Additional brain tumors not removed during surgery will be treated with stereotactic radiation alone, which is standard of care.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04365374' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 341 miles
Cedars Sinai Medical Center
Los Angeles,CA
VISITS: Number of visits unavailable, over 2 months
PHASE: II
NCT ID: NCT03546686
Immunotherapy & Cryoablation Before Surgery in Taxane Treated Triple Negative or ER Low, HER2- Tumors
A Randomized Phase 2 Study of Peri-Operative Ipilimumab, Nivolumab and Cryoablation Versus Standard Peri-Operative Care in Women With Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer. Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ipilimumab (Yervoy®), by IV, 1-5 days prior to core biopsy and cryoablation</li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, 1-5 days prior to core biopsy and cryoablation, and then every 2 weeks after surgery, for 6 weeks</li> <li class="seamTextUnorderedListItem">Core biopsy/Cryoablation, 7-10 days prior to surgery</li> <li class="seamTextUnorderedListItem">Breast surgery (standard-of-care) </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation uses extreme cold to kill cancer cells. It is not an established breast cancer treatment. </li> <li class="seamTextUnorderedListItem">Yervoy is an immunotherapy. It gets the immune system to see cancer cells by blocking the CTLA-4 protein. It is approved to treat metastatic melanoma. Its use in breast cancer is considered experimental. </li> <li class="seamTextUnorderedListItem">Opdivo is an immunotherapy that gets the immune system to go after cancer cells by blocking a protein called PD-1. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling women with triple negative as well as ER Low breast cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03546686' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/ipilimumab-yervoy' target='_blank'>Cancer Research UK: Ipilimumab (Yervoy)</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/Nivolumab.aspx' target='_blank'>Chemocare: Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/cryotherapy' target='_blank'>Breastcancer.org: Cryotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sciencedaily.com/releases/2018/11/181128082721.htm' target='_blank'>Science Daily: Cryoablation</a> </li></ul>
NEAREST SITE: 342 miles
Office of Dennis R. Holmes, M.D., F.A.C.S.
Glendale,CA
VISITS: 2 visits
PHASE: NA
NCT ID: NCT05218044
Cryoablation Minimally Invasive Alternative to Surgery for Women with DCIS
Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation, 1 time</li> </ul> <p class="seamTextPara"> followed 6 months later by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation is an experimental minimally invasive, cost effective alternative to surgery that is currently being evaluated for early stage breast cancer.</li> <li class="seamTextUnorderedListItem">Cryoablation involves insertion of a probe into the breast that freezes and destroys the abnormal tissue.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05218044' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://helenreybreastcancerfoundation.com/dcis-cryoablation-study' target='_blank'>Helen Rey Breast Cancer Foundation: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cryoablation' target='_blank'>National Cancer Institute: Cryoablation</a> </li></ul>
NEAREST SITE: 353 miles
City of Hope
Duarte,CA
VISITS: 2 visits within 1.5 months
PHASE: NA
NCT ID: NCT03463954
Novilase® Laser Ablation Before Surgery for Women with Stage I-II BRCA Negative Breast Cancer
Prospective, Multicenter Confirmatory Clinical Evaluation of Novilase® Interstitial Laser Therapy for the Focal Destruction of Malignant Breast Tumors ≤15 mm (BR-003) Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Novilase® laser ablation</li> </ul> <p class="seamTextPara"> followed 1-1.5 months later by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery to remove tumor</li> <li class="seamTextUnorderedListItem">MRI scan</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Novilase® laser ablation system kills tumor cells by heating the tissue with a laser.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03463954' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://novilase.com/' target='_blank'>Novian Health: Novilase®</a> </li></ul>
NEAREST SITE: 353 miles
City of Hope Medical Center
Duarte,CA
VISITS: May require hospitalization
PHASE: II
NCT ID: NCT05139043
Dexamethasone to Reduce Swelling after Brain Surgery
Safety and Imaging of Post-Operative Low Dose Versus Standard Dose Dexamethasone in Patients With Primary or Metastatic Brain Tumors: a Randomized, Double-blinded Feasibility Study. Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, daily for 3 days</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dexamethasone, by IV</li> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dexamethasone, by IV, daily for 3 days</li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, daily for 2 weeks</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery is an important part of the treatment of brain tumors. However, surgery results in injury to surrounding brain tissue and leads to brain swelling.</li> <li class="seamTextUnorderedListItem">Dexamethasone is effective for controlling the swelling of the brain. However, dexamethasone can cause many unwanted side effects.</li> <li class="seamTextUnorderedListItem">To minimize the side effects of dexamethasone, the lowest dose should be used.</li> <li class="seamTextUnorderedListItem">In this trial, you will receive 1 of 2 dose levels of dexamethasone: standard dose or lower dose.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05139043' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 656 miles
Integro Theranostics Research Site #2
Scottsdale,AZ
VISITS: Coincides with surgery
PHASE: I-II
NCT ID: NCT05900986
Imaging Dye During Surgery for DCIS or Stage I-II Breast Cancer
An Open-label, Single-arm, Phase 1b/2 Study to Investigate the Safety, Efficacy and Pharmacokinetics of LS301-IT in Female Patients Undergoing Partial Mastectomy and Sentinel Lymph Node Biopsy (SLNB) for Ductal Carcinoma in Situ (DCIS) or Stage I-II Primary Invasive Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LS301-IT, by IV, 1 time during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LS301-IT is an experimental tracer for imaging scans that may help locate cancer and tumor margins in the body.</li> <li class="seamTextUnorderedListItem">Margins are the area around where the tumor was removed. A negative margin means cancer was not found in the margin, and a positive margin means cancer was found in the margin.</li> <li class="seamTextUnorderedListItem">Your surgeon may use LS301-IT to find and remove all cancer cells during surgery.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">A sentinel lymph node biopsy is used to see if breast cancer cells are found in the sentinel node, the first lymph node under the arm to which the cancer cells are most likely to have spread.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05900986' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://integrotheranostics.com/' target='_blank'>Integro Theranostics: LS301-IT</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy' target='_blank'>Breastcancer.org: Lumpectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph-node-removal/sentinel-node-dissection' target='_blank'>Breastcancer.org: Sentinel Lymph Node Biopsy</a> </li></ul>
NEAREST SITE: 666 miles
University of Washington
Seattle,WA
VISITS: 1 visit
PHASE: NA
NCT ID: NCT05113927
SELENE System to Reduce Positive Margins During Lumpectomies for Women with DCIS or Stage I-III Breast Cancer
A Prospective, Multi-center, Randomized, Double-arm Trial to Determine the Impact of the SELENE System on Positive Margin Rates in Breast Conservation Surgery. Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following (Please contact research site for treatment schedule): </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care lumpectomy</li> <li class="seamTextUnorderedListItem">Standard of care margin assessment</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care lumpectomy</li> <li class="seamTextUnorderedListItem">SELENE system margin assessment</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaire within 1-3 months after surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The SELENE system uses optical coherence tomography (OCT), a type of light wave technology, to visualize and assess tumor margins during surgery.</li> <li class="seamTextUnorderedListItem">Margins are the area around where the tumor was removed. A negative margin means cancer was not found in the margin, and a positive margin means cancer was found in the margin.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05113927' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://perimetermed.com/clinical-trial-enrollment/' target='_blank'>Perimeter Medical Imaging AI: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://perimetermed.com/' target='_blank'>Perimeter Medical Imaging AI: Perimeter OCT Technology</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy' target='_blank'>Breastcancer.org: Lumpectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/pathology-report' target='_blank'>Breastcancer.org: Tumor Margins</a> </li></ul>
NEAREST SITE: 941 miles
University of Colorado Hospital
Aurora,CO
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT04558138
Mastectomy with Immediate Reconstruction With or Without Spending the Night in the Hospital
A Randomized Controlled Trial in Patients Undergoing Immediate Implant-Based Breast Reconstruction Utilizing an Enhanced Recovery Pathway Comparing Outcomes and Patient Satisfaction Based on Time of Discharge Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Not Spending the Night in the Hospital</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Released from hospital the day of surgery</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times in 1 week</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Spending the Night in the Hospital</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Released from hospital the day after surgery</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times in 1 week</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Traditionally people undergoing a mastectomy with immediate reconstruction are admitted to the hospital overnight.</li> <li class="seamTextUnorderedListItem">This trial will study whether discharge on the same day of surgery poses any major risks compared to discharge the day after surgery.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04558138' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li></ul>
NEAREST SITE: 1418 miles
University of Nebraska Medical Center
Omaha,NE
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT01535430
Studying Speech, Movement, and Senses During Brain Surgery for Brain Metastasis
Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognitive testing</li> <li class="seamTextUnorderedListItem">MRI and fMRI scans</li> <li class="seamTextUnorderedListItem">DTI tractograms</li> <li class="seamTextUnorderedListItem">MEG studies</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Awake brain mapping and surgery to remove brain tumor</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A craniotomy is a type of brain surgery. The surgeon will remove part of your skull (cranium) to access your brain to remove the tumors.</li> <li class="seamTextUnorderedListItem">You will be awake during the craniotomy to monitor how the surgery is affecting your speech, movement, and senses. Your scalp will be anesthetized, so you will not feel the operation or any pain.</li> <li class="seamTextUnorderedListItem">You will receive cognitive testing, MRI and fMRI scans, DTI tractograms, and MEG studies before and after surgery.</li> <li class="seamTextUnorderedListItem">Cognitive tests study your cognition, which is your ability to think.</li> <li class="seamTextUnorderedListItem">Magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) scans produce brain images created by magnetic energy rather than x-ray energy.</li> <li class="seamTextUnorderedListItem">A DTI tractogram is a type of MRI scan that produces brain images created by radio waves and magnetic fields.</li> <li class="seamTextUnorderedListItem">MEG studies measure the magnetic fields produced by your brain.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01535430' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://braintumorcenter.ucsf.edu/treatments/surgery/awake-brain-mapping-faq' target='_blank'>UCSF Brain Tumor Center: Awake Craniotomy</a> </li></ul>
NEAREST SITE: 1509 miles
UT Southwestern Medical Center
Dallas,TX
VISITS: 1 visit that coincides with surgery
PHASE: I-II
NCT ID: NCT02807597
Using an Experimental Technique to Look for Cancer Cells During a Lumpectomy (Breast Conserving Surgery)
Evaluation of LS301 Uptake in Tumors of Patients Undergoing Partial Mastectomy and Sentinel Lymph Node Biopsy for Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LS301, by IV, 4 to 24 hours before surgery</li> <li class="seamTextUnorderedListItem">Lumpectomy (breast conserving surgery)</li> <li class="seamTextUnorderedListItem">A Cancer Vision Goggles review of the breast tissue removed during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The goal of a lumpectomy is to remove all of the tumor and a rim of normal tissue from around the tumor. The rim of normal tissue is also called the margin or surgical margin. </li> <li class="seamTextUnorderedListItem">During or after surgery, the margin will be looked at by a type of doctor called a pathologist to see if there are any cancer cells in the margin. </li> <li class="seamTextUnorderedListItem">It may affect your treatment plan if cancer cells are found in the margin. Some people with cancer cells in the margin may need more surgery and/or radiation. </li> <li class="seamTextUnorderedListItem">This trial is studying a new technique to determine if there are cancer cells in the margin--the technique uses the dye LS301 and Cancer Vision Goggles. </li> <li class="seamTextUnorderedListItem">LS301 is injected into your body, and then attaches itself to cancer cells in your breast. </li> <li class="seamTextUnorderedListItem">Cancer Vision Goggles are experimental glasses that allow a surgeon to see any cancer cells LS301 has attached to in the breast.</li> <li class="seamTextUnorderedListItem">Research suggests that using LS301 and Cancer Vision Goggles together may allow surgeons to immediately see if they have removed all of the tumor during a lumpectomy and whether the margins are free of cancer cells.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02807597' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/diagnosis/margins' target='_blank'>Breastcancer.org: Surgical Margins</a> </li><li class='seamTextUnorderedListItem'><a href='https://source.wustl.edu/2020/03/cancerous-tumors-surrounding-cells-illuminated-by-new-imaging-agent/' target='_blank'>The Source: Cancerous Tumors, Surrounding Cells Illuminated by New Imaging Agent</a> </li><li class='seamTextUnorderedListItem'><a href='https://outlook.wustl.edu/2014/aug/seeing-cancer/' target='_blank'>Outlook Magazine: Cancer Vision</a> </li></ul>
NEAREST SITE: 1509 miles
UT Southwestern
Dallas,TX
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT05245812
Robotic Nipple Sparing Mastectomy for Women with DCIS, Stage I-III Breast Cancer, or at High Risk for Breast Cancer
Safety and Feasibility of Robotic Single-port (SP) Nipple Sparing Mastectomy: A Single Institution, Single Arm Pilot Trial Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nipple sparing mastectomy with da Vinci single port (SP) Surgical System</li> <li class="seamTextUnorderedListItem">Immediate breast reconstruction with tissue expanders/implants and acellular dermal matrix (Alloderm®)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A mastectomy is surgery to remove a breast.</li> <li class="seamTextUnorderedListItem">A nipple sparing mastectomy (NSM) leaves most of the healthy breast skin, including the nipple.</li> <li class="seamTextUnorderedListItem">The da Vinci single port (SP) Surgical System is an experimental surgery system designed for surgeons to perform minimally invasive surgery, such as nipple sparing mastectomy.</li> <li class="seamTextUnorderedListItem">The da Vinci SP Surgical System is approved for use during other surgeries.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05245812' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.intuitive.com/en-us/patients/procedures/general-surgery##' target='_blank'>Intuitive Surgical Device Information Page: Da Vinci Surgical System</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cedars-sinai.org/health-library/diseases-and-conditions/n/nipple-sparing-mastectomy.html' target='_blank'>Cedars-Sinai: Nipple Sparing Mastectomy</a> </li></ul>
NEAREST SITE: 1509 miles
University of Texas Southwestern
Dallas,TX
VISITS: At least 4 visits over 3 weeks including surgery; may require hospitalization
PHASE: NA
NCT ID: NCT01668082
Tissue Collection During Surgery for Brain Metastasis
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI and PET scans, 1-2 weeks before surgery</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">U-13C-glucose, by IV and/or 1,2-13C-acetate, by IV</li> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor tissue</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">On the day of surgery, you will receive U-13C-glucose and/or 1,2-13C-acetate naturally occurring chemicals to study brain metastasis activity.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01668082' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN
VISITS: Weekly study visits during radiation treatment
PHASE: NA
NCT ID: NCT02945579
Neoadjuvant Chemo & Radiation But No Surgery for Stage I-II Triple Negative or ER Low, HER2- or HER2 Positive Breast Cancer
Eliminating Breast Cancer Surgery in Exceptional Responders With Neoadjuvant Systemic Therapy Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An image-guided biopsy (a biopsy that uses imaging such as CT, ultrasound, MRI or mammography)</li> <li class="seamTextUnorderedListItem">If the biopsy does not show any evidence of disease, you will then have radiation therapy</li> <li class="seamTextUnorderedListItem">If the biopsy show evidence of disease, you will have surgery then radiation therapy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neoadjuvant chemotherapy (treatment given before surgery) is used to shrink tumors before surgery. The tumor may even disappear. When this occurs, researchers think it may be possible for patients to avoid surgery.</li> <li class="seamTextUnorderedListItem">Breast cancer that tests positive for 1%-10% estrogen receptors is called ER Low.</li> <li class="seamTextUnorderedListItem">This trial is enrolling women with triple negative as well as ER Low breast cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02945579' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li></ul>
NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT04047264
Microdialysis During Surgery for Metastatic Breast Cancer that has Spread to the Brain
Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Microdialysis during a biopsy or surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A biomarker is a gene, protein, or molecule produced by the body or tumor in a person with cancer that tells a doctor something about the cancer cells. </li> <li class="seamTextUnorderedListItem">Microdialysis is a procedure used for collecting a small volume of liquid during surgery. This liquid contains substances that may provide valuable information to doctors about the nearby cancer.</li> <li class="seamTextUnorderedListItem">Microdialysis will be performed during surgery while your brain tumor is being removed.</li> <li class="seamTextUnorderedListItem">Information collected in this study may help doctors to develop new strategies to better diagnose, monitor, and treat brain tumors.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04047264' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.news-medical.net/life-sciences/What-is-Microdialysis.aspx' target='_blank'>News Medical: What is Microdialysis?</a> </li></ul>
NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN
VISITS: At least 3 visits including surgery; may require hospitalization
PHASE: NA
NCT ID: NCT04692337
Ommaya Reservoir Placement to Collect CSF Samples for Brain Metastasis
Ommaya Reservoir Placement for Brain Tumor Biomarker Access Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to place Ommaya reservoir</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Collection of CSF from Ommaya reservoir, 2 or more times</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for schedule.</i></p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An Ommaya reservoir will be placed during brain surgery.</li> <li class="seamTextUnorderedListItem">Ommaya reservoirs are very small plastic devices put under the scalp to give access to cerebrospinal fluid (CSF), the fluid or liquid surrounding your brain and spinal cord.</li> <li class="seamTextUnorderedListItem">CSF samples will be used to study brain cancer activity and develop new brain cancer treatments.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04692337' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/faq-about-ommaya-reservoirs-and-ommaya-taps' target='_blank'>Memorial Sloan Kettering Cancer Center: Ommaya Reservoir</a> </li></ul>
NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT04810871
Brain Surgery Before Recurrence for Brain Metastasis
Surgical Resection of Latent Brain Tumors Prior to Recurrence Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will receive brain surgery to remove your brain tumor before the tumor comes back (recurrence).</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04810871' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX
VISITS: Number of visits unavailable
PHASE: NA
NCT ID: NCT05118295
SAVI Scout Device to Find Breast Tumor Before Lumpectomy for Stage I-III Breast Cancer
Single Step Lesion Annotation and Localization of Suspicious Breast Lesions Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placement of SAVI Scout reflector in your breast or lymph node, through a needle, during mammogram or ultrasound</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The SAVI Scout reflector is an FDA-approved device that is implanted into your breast or lymph node through a needle during a mammogram or ultrasound. The device helps your surgeon find your tumor that will be removed during a lumpectomy.</li> <li class="seamTextUnorderedListItem">The SAVI Scout reflector will also be removed during a lumpectomy.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05118295' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pennmedicine.org/cancer/types-of-cancer/breast-cancer/breast-cancer-treatment/lumpectomy/savi-scout' target='_blank'>University of Pennsylvania: SAVI Scout System</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy' target='_blank'>Breastcancer.org: Lumpectomy</a> </li></ul>
NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT02754544
Brain Surgery and Electrocorticography for Brain Metastasis
Pilot Investigation of Using Electrocorticogram (ECoG) in Predicting Eloquent Cortex and Post-Operative Functional Outcomes in Patients With Brain Tumors Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> <li class="seamTextUnorderedListItem">Electrocorticography</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">During brain surgery, you will complete various tasks to allow doctors to identify which areas of the brain are active during brain surgery, which is called electrocorticography.</li> <li class="seamTextUnorderedListItem">Tasks include speaking and moving parts of your body.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02754544' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX
VISITS: 1 visit
PHASE: NA
NCT ID: NCT02918474
A Tool to Help Women Decide Whether to Have a Contralateral Preventative Mastectomy
Decision Making Tool for Contralateral Prophylactic Mastectomy Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> You will complete a questionnaire before and after using the decision support tool.</p>
-
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">If you take part in this study, you will complete a questionnaire about the decision support tool.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02918474' target='_blank'>ClinicalTrials.gov</a> </li></ul>
NEAREST SITE: 1643 miles
MD Anderson
Houston,TX
VISITS: 1 visit that coincides with surgery
PHASE: NA
NCT ID: NCT04606030
Using a Biobridge Scaffold During Lymphedema Surgery
LymphBridge: Prospective Evaluation of the BioBridge Scaffold as an Adjunct to Lymph Node Transplant for Upper Extremity Lymphedema Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT) </li> <li class="seamTextUnorderedListItem">BioBridge Collagen Matrix inserted into your body during surgery </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Vascularized Lymph Node Transplant surgery (VLNT)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that may develop as a side effect of some breast cancer therapies. </li> <li class="seamTextUnorderedListItem">Lymphedema happens when there is a blockage in your lymphatic system (a part of your immune system) that stops the lymph fluid from draining well. The fluid buildup causes the abnormal swelling. </li> <li class="seamTextUnorderedListItem">The surgery used in this trial to help with your lymphedema is called a vascularized lymph node transfer.</li> <li class="seamTextUnorderedListItem">Your doctor will insert a Biobridge scaffold during your vascularized lymph node transfer. </li> <li class="seamTextUnorderedListItem">The Biobridge scaffold is made of collagen and may help lymph vessels grow around lymph blockages.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04606030' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/conditions-and-diseases/breast-cancer/breast-cancer-lymphedema-after-treatment' target='_blank'>Johns Hopkins Medicine: Breast Cancer, Lymphedema After Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://intermountainhealthcare.org/services/cancer-care/treatments-and-procedures/lymphedema-treatment/our-services/vascularized-lymph-node-transfer/' target='_blank'>Intermountain Healthcare: Vascularized Lymph Node Transfer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fibralignbio.com/biobridge-2/' target='_blank'>Fibralign Corporation Medical Device Information Page: Biobridge</a> </li></ul>
NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO
VISITS: At least 5 visits within 3 years
PHASE: NA
NCT ID: NCT05972343
Cryoablation for Breast Cancer
COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients: A Prospective Observational Registry Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation, 1 time</li> <li class="seamTextUnorderedListItem">Imaging scans, 4 times in 3 years</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cryoablation is a procedure in which an extremely cold liquid or device is used to freeze and destroy cancer cells.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05972343' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cryoablation' target='_blank'>National Cancer Institute: Cryoablation</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/cryotherapy' target='_blank'>Breastcancer.org: Cryotherapy</a> </li></ul>
NEAREST SITE: 1739 miles
Washington University in St. Louis
Saint Louis,MO
VISITS: 2 visits
PHASE: II
NCT ID: NCT05545150
Device to Remove All Tumor Cells During Surgery for Women with DCIS and Stage I-III Breast Cancer
Volumetric Lumpectomy Specimen Image Visualization for Intraoperatively Directing Cavity Shaves, a Phase II Study (VIVID) Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Imaging with Volumetric Specimen Imager device during lumpectomy/partial mastectomy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Clarix Volumetric Specimen Imager (VSI) device may help surgeons identify and remove all positive margins and tumor cells during a lumpectomy/partial mastectomy.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy. It is a standard of care (routine) procedure that removes the tumor and a rim of surrounding normal tissue (margins) while leaving as much normal breast tissue as possible.</li> <li class="seamTextUnorderedListItem">A margin that does not contain tumor cells is called a negative margin and tells the surgeon that the primary tumor has been removed. A positive margin contains tumor cells at or near the edge of the tissue removed.</li> <li class="seamTextUnorderedListItem">If tumor cells are detected in the margin, a second surgery may be required to remove additional tissue until the tumor has been completely removed from the margin.</li> <li class="seamTextUnorderedListItem">The imaging used in this study may reduce the need for a second surgery for people who previously received a lumpectomy/partial mastectomy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05545150' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.clariximaging.com/' target='_blank'>Clarix Imaging: Volumetric Specimen Imager</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/diagnosis/biopsies/assessing-margins/#:~:text=What%20is%20a%20margin%3F,of%20the%20tumor%20was%20removed.' target='_blank'>Susan G. Komen: Assessing Margins After Breast Surgery</a> </li></ul>
NEAREST SITE: 1761 miles
University of Wisconsin
Madison,WI
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT05859971
Sentinel Lymph Node Mapping with Asimov Imaging Platform for Stage I-III Breast Cancer
Use of ICG-fluorescent Imaging for Sentinel Lymph Node Mapping in Patients With Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following during sentinel lymph node (SLN) mapping surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Isosulfan blue dye, by injection</li> <li class="seamTextUnorderedListItem">Indocyanine green (ICG) dye, by injection</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Imaging with Asimov Imaging Platform</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A sentinel lymph node (SLN) mapping or biopsy is used to see if breast cancer cells are found in the sentinel node, the first lymph node under the arm to which the cancer cells are most likely to have spread.</li> <li class="seamTextUnorderedListItem">During surgery, the Asimov Imaging Platform, an experimental imaging system, will be used to visualize isosulfan blue dye and indocyanine green (ICG) dyes to see your lymph nodes and the lymphatic channels that drain your arm.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05859971' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/diagnosis-staging/staging/sentinel-node-biopsy-fact-sheet' target='_blank'>National Cancer Institute: Sentinel Lymph Node (SLN) Mapping</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/indocyanine-green-intravenous-route/description/drg-20155722' target='_blank'>Mayo Clinic: Indocyanine Green</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/isosulfan-blue' target='_blank'>National Cancer Institute: Isosulfan Blue</a> </li></ul>
NEAREST SITE: 1832 miles
Froedtert Hospital & Medical College of Wisconsin
Milwaukee,WI
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT04545814
Stereotactic Radiosurgery Before Brain Surgery for Brain Metastases
A Pilot Study Analyzing Preoperative Stereotactic Radiosurgery (SRS) With Gamma Knife (GK) for Brain Metastases Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery</li> </ul> <p class="seamTextPara"> followed 1-10 days later by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04545814' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 1854 miles
AMITA Health Saint Joseph Chicago
Chicago,IL
VISITS: Coincides with surgery
PHASE: II
NCT ID: NCT05554211
Tranexamic Acid to Reduce Drainage After Bilateral Mastectomy
Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tranexamic acid, by skin</li> <li class="seamTextUnorderedListItem">Gentamicin</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard Treatment</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo (saline) for tranexamic acid, by skin</li> <li class="seamTextUnorderedListItem">Gentamicin</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A bilateral mastectomy is surgery to remove both breasts.</li> <li class="seamTextUnorderedListItem">Women with a strong family history of breast cancer or a BRCA mutation may choose to undergo a bilateral mastectomy to reduce their risk of developing breast cancer.</li> <li class="seamTextUnorderedListItem">Drains help remove fluid build up in the area where the breast is removed.</li> <li class="seamTextUnorderedListItem">Tranexamic acid is an FDA approved drug that promotes blood clotting by preventing the breakdown of blood clots that your body naturally forms.</li> <li class="seamTextUnorderedListItem">Tranexamic acid is commonly used to control bleeding in a variety of surgeries and is available in injection or oral forms. However, because it is not currently FDA approved for use in elective breast surgery, this drug is considered experimental in this study. </li> <li class="seamTextUnorderedListItem">Gentamicin is an antibiotic used to prevent infection after surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05554211' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://moffitt.org/cancers/breast-cancer/treatment/bilateral-mastectomy/' target='_blank'>Moffitt Cancer Center: Bilateral Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a612021.html' target='_blank'>Medline Plus: Tranexamic Acid</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.verywellhealth.com/managing-your-surgical-drains-following-breast-surgery-4021630' target='_blank'>Verywell Health: Surgical Drains After Breast Surgery</a> </li></ul>
NEAREST SITE: 2054 miles
University of Michigan (Data Collection Only)
Ann Arbor,MI
VISITS: Coincides with surgery and routine care
PHASE: NA
NCT ID: NCT04854005
Use of Upfront Sentinel Lymph Node Biopsy for Stage I-II HR+, HER2-, Node Positive Breast Cancer
Selective Use of ALND in cT1-2N1 HR+/HER2- Breast Cancer Patients With 1 or 2 Positive Sentinel Lymph Nodes Undergoing Upfront Breast Conservation: A Prospective Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary ultrasound (AUS)</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sentinel lymph node biopsy (SNLB)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary ultrasound (AUS) is an ultrasound of the armpit area to look for lymph nodes in the armpit that may contain cancer.</li> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND) is a procedure that removes most lymph nodes in the armpit.</li> <li class="seamTextUnorderedListItem">Sentinel lymph node biopsy (SLNB) is a procedure that evaluates the first few lymph nodes in the lymphatic chain in which cancer cells are most likely to have spread.</li> <li class="seamTextUnorderedListItem">ALND is known to be a more invasive procedure with more long-term complications than SLNB, particularly lymphedema.</li> <li class="seamTextUnorderedListItem">In this trial, HER2 low is defined as IHC 1+ and ISH-.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04854005' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercourse.org/axillary-ultrasound/' target='_blank'>Breast Cancer School: Axillary Ultrasound</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cedars-sinai.org/health-library/diseases-and-conditions/a/axillary-lymph-node-dissection.html#:~:text=Axillary%20lymph%20node%20dissection%20(ALND,to%20remove%20these%20lymph%20nodes.&text=ALND%20happens%20after%20cancer%20cells,side%20of%20th' target='_blank'>Cedars Sinai: Axillary Lymph Node Dissection</a> </li></ul>
NEAREST SITE: 2139 miles
Emory University Hospital/Winship Cancer Institute
Atlanta,GA
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT04895592
Stereotactic Radiosurgery and Dexamethasone Before Surgery for Brain Metastasis
Preoperative Radiosurgery for Brain Metastases Planned for Surgical Resection: A Two Arm Pilot Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery, 1-3 sessions within 1-5 days</li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth or IV, up to 3 weeks</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Dexamethasone is an anti-inflammation medication used to prevent and treat side effects of some cancer treatments.</li> <li class="seamTextUnorderedListItem">You will receive either a low or high dose of dexamethasone.</li> <li class="seamTextUnorderedListItem">Giving stereotactic radiosurgery before surgery may reduce the risk of cancer coming back after surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04895592' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 2193 miles
Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland,OH
VISITS: May require hospitalization
PHASE: I-II
NCT ID: NCT01891318
Stereotactic Radiosurgery Before Brain Surgery for Brain Metastasis
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery focuses the x-rays directly to the tumor and cause less damage to the normal tissue in the brain.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01891318' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 2260 miles
Allegheny General Hospital
Pittsburgh,PA
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT05341739
Stereotactic Radiosurgery and Brain Surgery for Brain Metastasis
A Phase II Study of Pre-Operative Stereotactic Radiosurgery Followed by Surgical Resection for Brain Metastases Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CT and MRI scan</li> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery, 3 sessions within 3-6 days</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaire</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">A computed tomography (CT) scan produces body pictures created by x-ray energy.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by magnetic energy rather than x-ray energy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05341739' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 2371 miles
University of Virginia
Charlottesville,VA
VISITS: 1-2 visits within 8 days
PHASE: I
NCT ID: NCT04796220
Thermal Treatment and Chemotherapy Before Surgery for Stage I-III Breast Cancer
Focused Ultrasound With Low-Dose Gemcitabine to Augment Immune Control of Early Stage Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, 1 time</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation of tumor, 1 time</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®), by IV, 1 time</li> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation of tumor, 1 time</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">EchoPulse ultrasound ablation applies high-intensity focused ultrasound waves to a tumor, which ablates (heats) the tumor tissue to kill cancer cells.</li> <li class="seamTextUnorderedListItem">Gemcitabine (Gemzar®) is a type of chemotherapy that kills cancer cells.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment, like chemotherapy, before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04796220' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.theraclion.com/products/echopulse/' target='_blank'>Theraclion: EchoPulse Ultrasound Ablation</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/treatments/16541-hifu-high-intensity-focused-ultrasound' target='_blank'>Cleveland Clinic: High-Intensity Focused Ultrasound</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/drugs/gemzar' target='_blank'>Breastcancer.org: Gemcitabine (Gemzar®)</a> </li></ul>
NEAREST SITE: 2383 miles
Mayo Clinic
Jacksonville,FL
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT04742231
Measuring Hand Strength During Brain Surgery to Predict How the Craniotomy Will Affect Motor Skills
Use of Handheld Dynamometer as a Novel Tool to Assess Motor Function During Awake Craniotomy for Brain Lesions Located Within or Adjacent to the Motor Cortex: A Single-Center Pilot Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> Your hand strength will be measured during surgery with a handheld device called a K-FORCE Grip dynamometer®.</p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A craniotomy is a type of brain surgery. The surgeon will remove part of your skull (cranium) to access your brain to remove the tumors. </li> <li class="seamTextUnorderedListItem">You will be awake during the craniotomy so that you can use a handheld device to monitor how the surgery is affecting your motor skills. </li> <li class="seamTextUnorderedListItem">Motor skills are body movements and include walking, hand movements (like writing), and other types of movement. </li> <li class="seamTextUnorderedListItem">K-FORCE Grip® is a handheld dynamometer. A dynamometer is a machine that is held in the hand and can measure the strength of your grip. </li> <li class="seamTextUnorderedListItem">Researchers believe measuring grip strength may predict how removing tumors will affect motor skills.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04742231' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/craniotomy' target='_blank'>Johns Hopkins Medicine: Craniotomy?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/tests-procedures/awake-brain-surgery/about/pac-20384913' target='_blank'>Mayo Clinic: Awake Brain Surgery</a> </li><li class='seamTextUnorderedListItem'><a href='https://k-invent.com/produit/k-force-grip/' target='_blank'>Kinvent Device Information Page: KForce Grip</a> </li></ul>
NEAREST SITE: 2395 miles
Moffitt Cancer Center
Tampa,FL
VISITS: 4 visits over 1 week including surgery; may require hospitalization
PHASE: II
NCT ID: NCT05267587
Stereotactic Radiosurgery and Craniotomy for Brain Metastasis
Pre-operative Hypofractionated Stereotactic Radiosurgery for Resectable Brain Metastases Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery, 3 days</li> </ul> <p class="seamTextPara"> followed 5 days later by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Craniotomy to remove tumor</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation (stereotactic radiosurgery) delivers high-dose, precisely-targeted radiation in fewer doses than traditional radiation therapy. </li> <li class="seamTextUnorderedListItem">A craniotomy is a type of brain surgery. The surgeon will remove part of your skull (cranium) to access your brain to remove the tumors.</li> <li class="seamTextUnorderedListItem">If there are additional brain metastases, they will also be treated with stereotactic radiosurgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05267587' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD
VISITS: Requires hospitalization
PHASE: NA
NCT ID: NCT02639325
Brain Surgery for Brain Metastasis and Tumor Related Epilepsy
Tumor Related Epilepsy Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery to remove brain tumor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Requires hospitalization for at least one week</li> <li class="seamTextUnorderedListItem">Questionnaires, cognitive assessments, and seizure diary</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. </li> <li class="seamTextUnorderedListItem">Researchers think surgery may improve outcomes for people with tumor-related epilepsy by stopping seizures or reducing the number of seizures.</li> <li class="seamTextUnorderedListItem">Cognitive assessments study your cognition, which is your ability to think.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02639325' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/brain-metastasis/' target='_blank'>MBCBrainMets.org: About Brain Metastasis</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/treatments-brain-metastasis/#toggle-id-7' target='_blank'>MBCBrainMets.org: Brain Metastasis Treatments</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/research-news/brain-mets/' target='_blank'>Metastastic Trial Talk: Treating Breast Cancer Brain Mets</a> </li></ul>
NEAREST SITE: 2440 miles
Central Maryland Oncology Center
Columbia,MD
VISITS: 1 visit before surgery
PHASE: NA
NCT ID: NCT04234386
One Dose of Radiation Therapy Before Surgery for Women with Stage I or Stage II, ER+, HER2- Breast Cancer
Phase Ib Dose Escalation of Single-Fraction Preoperative Stereotactic Partial-Breast Irradiation for Early-Stage Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> You will receive the following before surgery: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic partial breast radiation therapy, by GammaPod, one time</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation therapy uses fewer, more-targeted, higher-dose treatments than traditional radiation therapy.</li> <li class="seamTextUnorderedListItem">This method helps keep the healthy breast tissue from being damaged by the radiation therapy.</li> <li class="seamTextUnorderedListItem">GammaPod is the machine used in this study to give the stereotactic radiation therapy. It is approved for use during a lumpectomy for early stage breast cancer, but its use in this trial is considered experimental.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04234386' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.umms.org/ummc/pros/physician-briefs/cancer/breast/gammapod-less-invasive-radiotherapy-device-early-stage' target='_blank'>University of Maryland Medical Center: GammaPod</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lumpectomy/expectations' target='_blank'>Breastcancer.org: Lumpectomy, What to Expect</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825433/' target='_blank'>Journal Article: Use of Preoperative Radiation Therapy in Early-stage and Locally Advanced Breast Cancer</a> </li></ul>
NEAREST SITE: 2519 miles
Sidney Kimmel Cancer Center at Thomas Jefferson Univeristy
Philadelphia,PA
VISITS: 5 visits
PHASE: II
NCT ID: NCT04959474
Reducing Calories During Radiation Therapy for DCIS or Stage I-III Breast Cancer
SABR-CaRe: A Phase II Randomized Trial of Pre-Operative Stereotactic Ablative Radiation Therapy (SABR) With and Without Caloric Restriction for Early Stage Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic ablative radiation therapy (SABR) is a highly focused radiation treatment that gives an intense dose of radiation concentrated on a tumor, while limiting the dose to the surrounding organ.</li> <li class="seamTextUnorderedListItem">Giving SABR before surgery may make the tumor smaller.</li> <li class="seamTextUnorderedListItem">Adding dietary restriction to radiation therapy may help increase the effectiveness of the radiation and decrease the spread of the cancer to other places in the body.</li> <li class="seamTextUnorderedListItem">The reduced calorie diet consists of reducing your calorie intake by 25%.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04959474' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://stanfordhealthcare.org/medical-treatments/s/stereotactic-body-radiation-therapy.html#:~:text=Stereotactic%20ablative%20radiotherapy%20(SABR)%2C,dose%20to%20the%20surrounding%20organs.' target='_blank'>Stanford: Stereotactic Ablative Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.jefferson.edu/university/jmc/departments/radiation_oncology/news/07212014.html' target='_blank'>Thomas Jefferson University: Calorie Restriction and Breast Cancer</a> </li></ul>
NEAREST SITE: 2537 miles
Robert Wood Johnson University Hospital Somerset
Somerville,NJ
VISITS: 4 visits before surgery; 5 visits per week, for 6 weeks after surgery, over 4 months
PHASE: NA
NCT ID: NCT04871516
Radiation Therapy Before and After Surgery for Stage I-III, Node-Negative Breast Cancer
A Single Center Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy, 4 times before surgery</li> <li class="seamTextUnorderedListItem">followed by breast surgery</li> <li class="seamTextUnorderedListItem">followed by whole breast radiation therapy, 5 days a week, for 4 to 6 weeks</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to kill tumor cells.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04871516' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/treatment/type/radiation-therapy/' target='_blank'>Susan G. Komen: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://moffitt.org/newsroom/press-release-archive/radiation-therapy-prior-to-surgery-reduces-the-risk-of-secondary-tumors-in-early-stage-breast-cancer-patients/' target='_blank'>Moffit Cancer Center: Radiation Therapy Prior to Surgery</a> </li></ul>
NEAREST SITE: 2539 miles
Memorial Sloan Kettering at Basking Ridge (Consent Only)
Basking Ridge,NJ
VISITS: Coincides with surgery
PHASE: II
NCT ID: NCT04690348
Radiation During Surgery for Recurrent Brain Metastases
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery </li> <li class="seamTextUnorderedListItem">Cesium 131 (Cs131) brachytherapy (radiation), during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brachytherapy is a type of internal radiation therapy. It works by placing a radioactive material directly inside or next to the tumor. </li> <li class="seamTextUnorderedListItem">It takes less time than traditional radiation and uses a higher total radiation dose to treat a smaller area.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04690348' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/types/radiation-therapy/brachytherapy#:~:text=Brachytherapy%20is%20a%20type%20of%20internal%20radiation%20therapy%20in%20which,specific%20part%20of%20your%20body.' target='_blank'>Cancer.gov: Brachytherapy</a> </li></ul>
NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Consent and follow-up only)
Basking Ridge,NJ
VISITS: Coincides with surgery
PHASE: III
NCT ID: NCT03351348
Bupivacaine to Reduce Pain After Mastectomy for DCIS and Stage I-III Breast Cancer
Double Blind, Randomized, Placebo Controlled Trial of Locally Instilled Bupivacaine in the Surgical Bed After Unilateral Mastectomy Without Reconstruction Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for bupivacaine, by surgical drain</li> <li class="seamTextUnorderedListItem">Standard of care pain medications</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bupivacaine, by surgical drain</li> <li class="seamTextUnorderedListItem">Standard of care pain medications</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires, 2 times within 1 year</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bupivacaine is a FDA-approved numbing medicine used for some surgical and dental procedures.</li> <li class="seamTextUnorderedListItem">The addition of bupivacaine to the surgical wound site with standard of care pain medications could better manage your pain immediately after surgery and reduce the amount of opioid medications taken after surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03351348' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/bupivacaine-injection-route/description/drg-20406723#:~:text=Bupivacaine%20injection%20is%20used%20to,It%20is%20a%20local%20anesthetic.' target='_blank'>Mayo Clinic: Bupivacaine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/tests-procedures/mastectomy/expert-answers/pain-after-breast-surgery/faq-20058049' target='_blank'>Mayo Clinic: Pain After Breast Surgery</a> </li></ul>
NEAREST SITE: 2539 miles
Memorial Sloan Kettering Cancer Center (Limited Protocol Activities)
Basking Ridge,NJ
VISITS: Number of visits unavailable
PHASE: II
NCT ID: NCT05892068
Tucatinib Before Surgery for Metastatic HER2+ Breast Cancer That Has Spread to the Brain
Window of Opportunity Analysis of Pre-Operative Tucatinib for Surgically Resected HER2+ Brain Metastases: Understanding Mechanisms of Resistance Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa®), by mouth, daily for 5 days</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tucatinib (Tukysa) is a type of HER2 targeting therapy called a kinase inhibitor. It is able to cross the blood-brain barrier. This means it works against cancer cells that have spread to the brain. Tucatinib is approved for use in people with metastatic, HER2+ breast cancer when it is taken with trastuzumab and capecitabine. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05892068' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted-therapy/tukysa' target='_blank'>Breastcancer.org: Tucatinib</a> </li></ul>
NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ
VISITS: May require hospitalization
PHASE: I
NCT ID: NCT05412225
Radiation Before Mastectomy with Immediate Reconstruction for Stage III Breast Cancer
Feasibility of Preoperative Radiotherapy in T4 Breast Cancer Patients Who Are Responders to Neoadjuvant Chemotherapy to Allow for Immediate Reconstruction: A Prospective Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI scan</li> <li class="seamTextUnorderedListItem">Biopsy</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation</li> </ul> <p class="seamTextPara"> followed 2-6 weeks later by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Total mastectomy with immediate autologous reconstruction</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies. </li> <li class="seamTextUnorderedListItem">Mastectomy is a type of surgery to remove the entire breast.</li> <li class="seamTextUnorderedListItem">Immediate autologous reconstruction is breast reconstruction surgery immediately following your mastectomy. The surgeon will take tissue from another part of your body and use it to re-create your breast.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy. The MRI scan will help guide your biopsy before radiation and surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05412225' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/autologous-flap' target='_blank'>Breastcancer.org: Immediate Autologous Reconstruction</a> </li></ul>
NEAREST SITE: 2539 miles
Memorial Sloan Kettering Cancer Center at Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ
VISITS: Please contact research site
PHASE: I
NCT ID: NCT06246968
Pembrolizumab and Cryoablation for Advanced Triple Negative Breast Cancer
Does Cryoablation Boost Immune Response Improving the Benefits of Pembrolizumab in Patients With Metastatic or Locally Advanced Triple Negative Breast Cancer? Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®)</li> <li class="seamTextUnorderedListItem">Cryoablation</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor, which is a type of immune checkpoint inhibitor. Blocking PD-1 may allow the body's immune system to detect and fight cancer cells.</li> <li class="seamTextUnorderedListItem">Cryoablation is a procedure in which an extremely cold liquid or device is used to freeze and destroy cancer cells.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06246968' target='_blank'>ClinicalTrials.gov</a> </li></ul>
NEAREST SITE: 2567 miles
Weill Cornell Medicine
New York,NY
VISITS: 5 visits over 1-2 weeks
PHASE: II
NCT ID: NCT04371913
Radiation Therapy Instead of Surgery for Local Recurrence in Women 50+
Personalized Second Chance Breast Conservation (PSCBC): A Two Center Prospective Phase II Clinical Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Accelerated Partial Breast Radiation (APBI), 5 times, over 1-2 weeks</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Many women receive a lumpectomy (breast conserving surgery) and radiation therapy for early-stage breast cancer.</li> <li class="seamTextUnorderedListItem">It is called a local recurrence if your breast cancer returns to the breast that has already received surgery and radiation therapy.</li> <li class="seamTextUnorderedListItem">A mastectomy is the standard of care for treating a local recurrence.</li> <li class="seamTextUnorderedListItem">This trial is studying if it is safe to use radiation therapy instead of a mastectomy for a local recurrence.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04371913' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/diagnosis-treatment/drc-20377141' target='_blank'>Mayo Clinic: Recurrent Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/radiation-for-breast-cancer.html' target='_blank'>American Cancer Society: Radiation for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-fraction-radiation-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Accelerated-Fraction Radiation Therapy</a> </li></ul>
NEAREST SITE: 2569 miles
Columbia University Irving Medical Center/NYP
New York,NY
VISITS: Number of visits unavailable
PHASE: NA
NCT ID: NCT05219695
Thermal Treatment for Stage I Breast Cancer and Benign Breast Tumors
Medical Imaging and Thermal Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI) Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Harmonic motion imaging (HMI) scan, 2 times</li> <li class="seamTextUnorderedListItem">Focus ultrasound (FUS) ablation of tumor</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Harmonic motion imaging (HMI) is a type of scan that can look for changes in tissue before and after focused ultrasound (FUS) ablation.</li> <li class="seamTextUnorderedListItem">Focused ultrasound (FUS) ablation applies high-intensity focused ultrasound waves to a tumor, which ablates (heats) the tumor tissue to kill cancer cells.</li> <li class="seamTextUnorderedListItem">The main advantage of focused ultrasound (FUS) ablation is that it avoids surgery. Without surgery, recovery from the procedure is faster with less pain, and cosmetological results may be improved.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li> <li class="seamTextUnorderedListItem">The two most common types of benign breast lumps are cysts and fibroadenomas.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05219695' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ueil.bme.columbia.edu/research-projects/harmonic-motion-imaging' target='_blank'>Columbia University: Harmonic Motion Imaging</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/other/high-intensity-focused-ultrasound-hifu' target='_blank'>Cancer Research UK: High-Intensity Focused Ultrasound</a> </li></ul>
NEAREST SITE: 2591 miles
University of Miami
Miami,FL
VISITS: 5 days, over 2 weeks
PHASE: NA
NCT ID: NCT04360330
Stereotactic Radiation Therapy Before Lumpectomy for Women 50+ with Stage I, HR+, HER2- Breast Cancer
Phase I Study to Evaluate the Safety and Feasibility of Preoperative Ablative Breast Radiotherapy (SABER) for Selected Early Stage Breast Cancer (SABER) Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
-
<p class="seamTextPara"> Before surgery, you will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic Ablative Breast Radiotherapy (SABER), for 5 days, over 2 weeks</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiation therapy delivers a higher targeted dose of radiation in fewer sessions than standard radiation therapy.</li> <li class="seamTextUnorderedListItem">This trial is looking at the effects of giving stereotactic radiation before surgery. </li> <li class="seamTextUnorderedListItem">Typically, this type of radiation therapy is given after surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04360330' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nationalbreastcancer.org/breast-cancer-radiation-therapy' target='_blank'>National Breast Cancer Foundation: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://stanfordhealthcare.org/medical-treatments/s/stereotactic-body-radiation-therapy.html' target='_blank'>Standford Healthcare: Stereotactic Ablative Radiotherapy (SABR/SBRT)</a> </li></ul>
NEAREST SITE: 2591 miles
University of Miami
Miami,FL
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT04998682
Removing Lymph Nodes During Surgery for Stage III Breast Cancer
TAD: Prospective Evaluation of Targeted Axillary Dissection After Neoadjuvant Systemic Therapy in Patients With Breast Cancer With Advanced Nodal Disease at Diagnosis Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Removal of axillary lymph nodes during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The surgery that examines and/or removes lymph nodes from your underarm/armpit area is called a targeted axillary dissection (TAD), sometimes also called an axillary lymph node dissection (ALND). </li> <li class="seamTextUnorderedListItem">During surgery, a blue dye will be used to see your lymph nodes and the lymphatic channels that drain your arm.</li> <li class="seamTextUnorderedListItem">Node positive means cancer has spread to your lymph nodes.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04998682' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph-node-removal/axillary-dissection' target='_blank'>Breastcancer.org: Axillary Lymph Node Dissection</a> </li></ul>
NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA
VISITS: Number of visits unavailable
PHASE: NA
NCT ID: NCT04033497
MRI-Based Imaging Technique to Distinguish Recurrent Brain Metastases from Radiation Damage
Treatment Response Assessment Maps (TRAMs) in the Delineation of Radiation Necrosis From Tumor Progression After Stereotactic Radiation in Patients With Brain Metastases: A Prospective Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brain imaging by MRI and Treatment Assessment Maps <i class="seamTextEmphasis">followed by</i></li> <li class="seamTextUnorderedListItem">Brain surgery to remove suspected recurrence of brain metastasis</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Treatment Response Assessment Maps is an MRI-based imaging technique that may be able to distinguish recurrent brain metastases from radiation-damaged, but non-cancerous brain tissue.</li> <li class="seamTextUnorderedListItem">This technique may allow future patients to avoid unnecessary surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04033497' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>