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Find Breast Cancer Clinical Trials That Are Right For You
The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.
Use the search box and filters to find a trial that’s right for you.
Currently viewing trials
(Last updated: March 18, 2023)
Brain Mets
BRCA1/2 (inherited)
Chemotherapy
Hormone Therapy
Leptomeningeal Disease
Radiation Oncology
Surgery
Surgery: Reconstruction
Targeted Therapy: All
Targeted Therapy: Anti-HER2 Therapy
Targeted Therapy: CDK Inhibitors
Targeted Therapy: PARP Inhibitors
Targeted Therapy: Tumor Mutations
Targeted Therapy: Other Targeted Therapy
Vaccines and Immunotherapy
Other Treatment
Activities
Complementary and Alternative Medicine
Decision Support
Diagnosing Breast Cancer
Genetics/Family History
Having Children
Lymphedema
Managing Side Effects
No Travel Required
Predicting Response to Treatment
Preventing Breast Cancer
Preventing Recurrence
Screening
Support/Education
Surveys/Interviews/Registries
AKT
ALK
AR
BARD1
BRCA1/2 (tumor)
BRIP1
CD205
CD70
CHEK2 or CHEK1
ESR1
FGFR
HER2/ERBB2
HLA
MET or C-Met
NTRK
PALB2
PIK3CA or PI3K
PTEN
RAD51
RAF (including BRAF)
RAS (KRAS or NRAS)
RB
ROS1
TP53
NEAREST SITE: 1509 miles
UT Southwestern
Dallas,TX
VISITS: 2 visits within 2 months, then every 6 months for 5 years
PHASE: NA
NCT ID: NCT05245812
Robotic Nipple Sparing Mastectomy for Women with DCIS, Stage I-III Breast Cancer, or at High Risk for Breast Cancer
Safety and Feasibility of Robotic Single-port (SP) Nipple Sparing Mastectomy: A Single Institution, Single Arm Pilot Trial Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nipple sparing mastectomy with da Vinci single port (SP) Surgical System</li> <li class="seamTextUnorderedListItem">Immediate breast reconstruction with tissue expanders/implants and acellular dermal matrix (Alloderm®)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The da Vinci single port (SP) Surgical System is a system designed for surgeons to perform minimally invasive surgery, such as nipple sparing mastectomy.</li> <li class="seamTextUnorderedListItem">The da Vinci SP Surgical System is approved for use during other surgeries.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05245812' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.intuitive.com/en-us/products-and-services/da-vinci/systems/sp' target='_blank'>Intuitive: The Da Vinci SP Surgical System</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/consider-cx-characteristics-for-nipple-sparing-mx' target='_blank'>Breastcancer.org: Nipple Sparing Mastectomy</a> </li></ul>
NEAREST SITE: 2108 miles
Ohio State University Comprehensive Cancer Center
Columbus,OH
VISITS: 1 visit that coincides with surgery
PHASE: NA
NCT ID: NCT04537312
Using A Robot to Help with Nipple Sparing Mastectomy for Stage I-II Breast Cancer & DCIS
Prospective Pilot Study of Robot-Assisted Nipple Sparing Mastectomy (RNSM) Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will recieve the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Robot-assisted Nipple Sparing Mastectomy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A nipple-sparing mastectomy leaves your nipple, areola and the surrounding skin--but removes the breast tissue underneath. </li> <li class="seamTextUnorderedListItem">Nipple-sparing mastectomies can be difficult to perform because they use small incisions (openings). </li> <li class="seamTextUnorderedListItem">Researchers believe that using a robot will make it easier to use small incisions during surgery. </li> <li class="seamTextUnorderedListItem">The robot used in this trial is called the da Vinci surgical system. It is approved for use in other surgeries, but its use in this study is considered experimental.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04537312' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/consider-cx-characteristics-for-nipple-sparing-mx' target='_blank'>Breastcancer.org: In Appropriate Women, Nipple-Sparing Mastectomy Doesn’t Lead to Higher Breast Cancer Recurrence Rates</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.davincisurgery.com/procedures/general-surgery##' target='_blank'>Intuitive Surgical Device Information Page: Da Vinci Surgical System</a> </li><li class='seamTextUnorderedListItem'><a href='https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1567-y' target='_blank'>Journal Article: Breast Cancer Robotic Nipple Sparing Mastectomy: Evaluation of Several Surgical Procedures and Learning Curve</a> </li></ul>
NEAREST SITE: 2314 miles
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem,NC
VISITS: May require hospitalization
PHASE: NA
NCT ID: NCT05395936
Studying Breast Skin Temperature During Mastectomy for People with Stage I-III Breast Cancer
Mastectomy Flap Temperature and Clinical Implications Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care mastectomy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mastectomy is surgery to remove the breast.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05395936' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li></ul>
NEAREST SITE: 2537 miles
Robert Wood Johnson University Hospital Somerset
Somerville,NJ
VISITS: 4 visits before surgery; 5 visits per week, for 6 weeks after surgery, over 4 months
PHASE: NA
NCT ID: NCT04871516
Radiation Therapy Before and After Surgery for Stage I-III, Node-Negative Breast Cancer
A Single Center Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy, 4 times before surgery</li> <li class="seamTextUnorderedListItem">followed by breast surgery</li> <li class="seamTextUnorderedListItem">followed by whole breast radiation therapy, 5 days a week, for 4 to 6 weeks</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to kill tumor cells.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04871516' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/treatment/type/radiation-therapy/' target='_blank'>Susan G. Komen: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://moffitt.org/newsroom/press-release-archive/radiation-therapy-prior-to-surgery-reduces-the-risk-of-secondary-tumors-in-early-stage-breast-cancer-patients/' target='_blank'>Moffit Cancer Center: Radiation Therapy Prior to Surgery</a> </li></ul>
NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ
VISITS: May require hospitalization
PHASE: I
NCT ID: NCT05412225
Radiation Before Mastectomy with Immediate Reconstruction for Stage III Breast Cancer
Feasibility of Preoperative Radiotherapy in T4 Breast Cancer Patients Who Are Responders to Neoadjuvant Chemotherapy to Allow for Immediate Reconstruction: A Prospective Study Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI scan</li> <li class="seamTextUnorderedListItem">Biopsy</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation</li> </ul> <p class="seamTextPara"> followed 2-6 weeks later by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Total mastectomy with immediate autologous reconstruction</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to damage cancer cell DNA. These x-rays stop cancer cells from dividing and growing, thus slowing or stopping tumor growth.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies. </li> <li class="seamTextUnorderedListItem">Mastectomy is a type of surgery to remove the entire breast.</li> <li class="seamTextUnorderedListItem">Immediate autologous reconstruction is breast reconstruction surgery immediately following your mastectomy. The surgeon will take tissue from another part of your body and use it to re-create your breast.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy. The MRI scan will help guide your biopsy before radiation and surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05412225' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/radiation-therapy' target='_blank'>Breastcancer.org: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/mastectomy' target='_blank'>Breastcancer.org: Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/autologous-flap' target='_blank'>Breastcancer.org: Immediate Autologous Reconstruction</a> </li></ul>
NEAREST SITE: 2567 miles
Memorial Sloan Kettering Cancer Center
New York,NY
VISITS: 1 visit including surgery, may require hospitalization
PHASE: III-IV
NCT ID: NCT04016376
Nerve Block Pain Management in Patients Undergoing a Double Mastectomy With Immediate Reconstruction
Cluster-Randomized, Prospective Assessment of Postoperative Pain Management in Patients Undergoing Bilateral Mastectomy With Immediate Reconstruction With Tissue Expander (BMWRw/TE) Using Preoperative Paravertebral (PVB), Serratus+PECS-1, or PVB+PECS-1 Nerve Blocks Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVB nerve block, by injection in back</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVB nerve block, by injection in back</li> <li class="seamTextUnorderedListItem">PECS-1 nerve block, by injection in chest</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PECS-1 nerve block, by injection in chest</li> <li class="seamTextUnorderedListItem">Serratus nerve block, by injection in chest</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nerve blocks are a type of local anesthesia given before surgery.</li> <li class="seamTextUnorderedListItem">Anesthesia is medication that prevents pain during surgery.</li> <li class="seamTextUnorderedListItem">PVB, PECS-1, and/or serratus nerve blocks may also reduce the need for pain medication after surgery.</li> <li class="seamTextUnorderedListItem">You will receive an injection of anesthesia into a different part of your body for each nerve block.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04016376' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/conditions-and-diseases/nerve-blocks#:~:text=Nerve%20blocks%2C%20or%20neural%20blockades,feeling%20if%20needed%20for%20surgery.' target='_blank'>Johns Hopkins Medicine: Nerve Blocks</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.yalemedicine.org/conditions/nerve-blocks-for-surgery' target='_blank'>Yale Medicine: Nerve Blocks For Surgery</a> </li></ul>
NEAREST SITE: 2695 miles
Tufts Medical Center
Boston,MA
VISITS: Coincides with surgery
PHASE: II
NCT ID: NCT04603911
Comparing Two Different Pain Therapies for Use With a Nerve Block During Mastectomy with Immediate Reconstruction
An Investigator-Initiated, Double-Blind, Patient-Controlled, Randomized Control Trial Comparing the Effectiveness of Liposomal Bupivacaine to a Solution of Bupivacaine, Epinephrine Clonidine and Dexamethasone in Bilateral, Single Shot, Erector Spinae Plane Blocks During Oncoplastic Breast Surgery Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and receive the following during surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nerve block (ESPB Block), using bupivacaine, epinephrine, dexamethasone and clonidine</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nerve block (ESPB Block), using liposomal bupivacaine</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A nerve block is a procedure used during surgery. For this trial, the type of nerve block used is the ESPB Block. </li> <li class="seamTextUnorderedListItem">During your surgery, a local anesthesia will be injected into the muscles of your chest and arm pit. This injection will numb the nerves in the area where the surgery will be performed, and this may decrease the pain you feel after your surgery is over.</li> <li class="seamTextUnorderedListItem">Bupivacaine hydrochloride (Marcaine) is the standard of care pain therapy for this procedure.</li> <li class="seamTextUnorderedListItem">Liposomal bupivacaine is a form of Bupivacaine that may provide longer or better pain relief.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04603911' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.clinicaloncology.com/Breast-Cancer/Article/12-19/Benefits-Seen-With-Use-of-Regional-Blocks-For-Bilateral-Mastectomy-With-Reconstruction/56690' target='_blank'>Clinical Oncology News: Benefits Seen With Use of Regional Blocks For Bilateral Mastectomy With Reconstruction</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Bupivacaine' target='_blank'>Wikipedia: Bupivacaine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.asra.com/asra-news/article/182/con-liposomal-bupivacaine-a-mission-inco' target='_blank'>American Society of Regional Anesthesia and Pain Medicine: Liposomal Bupivacaine, A Mission Incomplete</a> </li></ul>