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Find Breast Cancer Clinical Trials That Are Right For You

The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.

Use the search box and filters to find a trial that’s right for you.


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(Last updated: December 03, 2022)

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Treatment

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Surgery: Reconstruction

Targeted Therapy: All

Targeted Therapy: Anti-HER2 Therapy

Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

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AKT

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CHEK2 or CHEK1

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HLA

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RAF (including BRAF)

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TP53

1

NEAREST SITE: 1509 miles
UT Southwestern
Dallas,TX

VISITS: 2 visits within 2 months, then every 6 months for 5 years

PHASE: NA

NCT ID: NCT05245812

Robotic Nipple Sparing Mastectomy for Women with DCIS, Stage I-III Breast Cancer, or at High Risk for Breast Cancer

Safety and Feasibility of Robotic Single-port (SP) Nipple Sparing Mastectomy: A Single Institution, Single Arm Pilot Trial Scientific Title

Purpose
To study the safety and effects (good and bad) of nipple sparing mastectomy with da Vinci single port (SP) Surgical System.
Who is this for?
Women with DCIS, stage I, stage II, or some stage III breast cancer, or at high risk for breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nipple sparing mastectomy with da Vinci single port (SP) Surgical System</li> <li class="seamTextUnorderedListItem">Immediate breast reconstruction with tissue expanders/implants and acellular dermal matrix (Alloderm®)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The da Vinci single port (SP) Surgical System is a system designed for surgeons to perform minimally invasive surgery, such as nipple sparing mastectomy.</li> <li class="seamTextUnorderedListItem">The da Vinci SP Surgical System is approved for use during other surgeries.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05245812' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.intuitive.com/en-us/products-and-services/da-vinci/systems/sp' target='_blank'>Intuitive: The Da Vinci SP Surgical System</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/consider-cx-characteristics-for-nipple-sparing-mx' target='_blank'>Breastcancer.org: Nipple Sparing Mastectomy</a> </li></ul>
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2

NEAREST SITE: 2108 miles
Ohio State University Comprehensive Cancer Center
Columbus,OH

VISITS: 1 visit that coincides with surgery

PHASE: NA

NCT ID: NCT04537312

Using A Robot to Help with Nipple Sparing Mastectomy for Stage I-II Breast Cancer & DCIS

Prospective Pilot Study of Robot-Assisted Nipple Sparing Mastectomy (RNSM) Scientific Title

Purpose
To study the safety and effects (good and bad) of using an experimental robot (the da Vinci surgical system) to help perform nipple-sparing mastectomies.
Who is this for?
People with stage I or stage II breast cancer or DCIS who will recieve a mastectomy at The James Ohio State University Comprehensive Cancer Center. You may also enroll in this trial if you will recieve a prophylactic mastectomy (removal of a breast that does not have cancer).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will recieve the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Robot-assisted Nipple Sparing Mastectomy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A nipple-sparing mastectomy leaves your nipple, areola and the surrounding skin--but removes the breast tissue underneath. </li> <li class="seamTextUnorderedListItem">Nipple-sparing mastectomies can be difficult to perform because they use small incisions (openings). </li> <li class="seamTextUnorderedListItem">Researchers believe that using a robot will make it easier to use small incisions during surgery. </li> <li class="seamTextUnorderedListItem">The robot used in this trial is called the da Vinci surgical system. It is approved for use in other surgeries, but its use in this study is considered experimental.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04537312' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/consider-cx-characteristics-for-nipple-sparing-mx' target='_blank'>Breastcancer.org: In Appropriate Women, Nipple-Sparing Mastectomy Doesn’t Lead to Higher Breast Cancer Recurrence Rates</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.davincisurgery.com/procedures/general-surgery##' target='_blank'>Intuitive Surgical Device Information Page: Da Vinci Surgical System</a> </li><li class='seamTextUnorderedListItem'><a href='https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1567-y' target='_blank'>Journal Article: Breast Cancer Robotic Nipple Sparing Mastectomy: Evaluation of Several Surgical Procedures and Learning Curve</a> </li></ul>
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3

NEAREST SITE: 2537 miles
Robert Wood Johnson University Hospital Somerset
Somerville,NJ

VISITS: 4 visits before surgery; 5 visits per week, for 6 weeks after surgery, over 4 months

PHASE: NA

NCT ID: NCT04871516

Radiation Therapy Before and After Surgery for Stage I-III, Node-Negative Breast Cancer

A Single Center Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients Scientific Title

Purpose
To study the safety, anti-cancer activity, and cosmetic outcomes of giving radiation therapy to the breast before and after surgery.
Who is this for?
People with stage I, stage II, or stage III node-negative breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy, 4 times before surgery</li> <li class="seamTextUnorderedListItem">followed by breast surgery</li> <li class="seamTextUnorderedListItem">followed by whole breast radiation therapy, 5 days a week, for 4 to 6 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high-energy x-rays to kill tumor cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04871516' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/treatment/type/radiation-therapy/' target='_blank'>Susan G. Komen: Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://moffitt.org/newsroom/press-release-archive/radiation-therapy-prior-to-surgery-reduces-the-risk-of-secondary-tumors-in-early-stage-breast-cancer-patients/' target='_blank'>Moffit Cancer Center: Radiation Therapy Prior to Surgery</a> </li></ul>
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4

NEAREST SITE: 2567 miles
Memorial Sloan Kettering Cancer Center
New York,NY

VISITS: 1 visit including surgery, may require hospitalization

PHASE: III-IV

NCT ID: NCT04016376

Nerve Block Pain Management in Patients Undergoing a Double Mastectomy With Immediate Reconstruction

Cluster-Randomized, Prospective Assessment of Postoperative Pain Management in Patients Undergoing Bilateral Mastectomy With Immediate Reconstruction With Tissue Expander (BMWRw/TE) Using Preoperative Paravertebral (PVB), Serratus+PECS-1, or PVB+PECS-1 Nerve Blocks Scientific Title

Purpose
To study whether nerve blocks before surgery reduce the need for pain medication after surgery.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who are planning to receive a bilateral mastectomy with immediate reconstruction at the Memorial Sloan Kettering Josie Robertson Surgical Center.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVB nerve block, by injection in back</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PVB nerve block, by injection in back</li> <li class="seamTextUnorderedListItem">PECS-1 nerve block, by injection in chest</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PECS-1 nerve block, by injection in chest</li> <li class="seamTextUnorderedListItem">Serratus nerve block, by injection in chest</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nerve blocks are a type of local anesthesia given before surgery.</li> <li class="seamTextUnorderedListItem">Anesthesia is medication that prevents pain during surgery.</li> <li class="seamTextUnorderedListItem">PVB, PECS-1, and/or serratus nerve blocks may also reduce the need for pain medication after surgery.</li> <li class="seamTextUnorderedListItem">You will receive an injection of anesthesia into a different part of your body for each nerve block.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04016376' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/conditions-and-diseases/nerve-blocks#:~:text=Nerve%20blocks%2C%20or%20neural%20blockades,feeling%20if%20needed%20for%20surgery.' target='_blank'>Johns Hopkins Medicine: Nerve Blocks</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.yalemedicine.org/conditions/nerve-blocks-for-surgery' target='_blank'>Yale Medicine: Nerve Blocks For Surgery</a> </li></ul>
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5

NEAREST SITE: 2695 miles
Tufts Medical Center
Boston,MA

VISITS: Coincides with surgery

PHASE: II

NCT ID: NCT04603911

Comparing Two Different Pain Therapies for Use With a Nerve Block During Mastectomy with Immediate Reconstruction

An Investigator-Initiated, Double-Blind, Patient-Controlled, Randomized Control Trial Comparing the Effectiveness of Liposomal Bupivacaine to a Solution of Bupivacaine, Epinephrine Clonidine and Dexamethasone in Bilateral, Single Shot, Erector Spinae Plane Blocks During Oncoplastic Breast Surgery Scientific Title

Purpose
To compare two different pain therapies for use with a nerve block during surgery.
Who is this for?
People scheduled to receive a mastectomy and immediate reconstruction in both breasts.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and receive the following during surgery: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nerve block (ESPB Block), using bupivacaine, epinephrine, dexamethasone and clonidine</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nerve block (ESPB Block), using liposomal bupivacaine</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A nerve block is a procedure used during surgery. For this trial, the type of nerve block used is the ESPB Block. </li> <li class="seamTextUnorderedListItem">During your surgery, a local anesthesia will be injected into the muscles of your chest and arm pit. This injection will numb the nerves in the area where the surgery will be performed, and this may decrease the pain you feel after your surgery is over.</li> <li class="seamTextUnorderedListItem">Bupivacaine hydrochloride (Marcaine) is the standard of care pain therapy for this procedure.</li> <li class="seamTextUnorderedListItem">Liposomal bupivacaine is a form of Bupivacaine that may provide longer or better pain relief.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04603911' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.clinicaloncology.com/Breast-Cancer/Article/12-19/Benefits-Seen-With-Use-of-Regional-Blocks-For-Bilateral-Mastectomy-With-Reconstruction/56690' target='_blank'>Clinical Oncology News: Benefits Seen With Use of Regional Blocks For Bilateral Mastectomy With Reconstruction</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Bupivacaine' target='_blank'>Wikipedia: Bupivacaine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.asra.com/asra-news/article/182/con-liposomal-bupivacaine-a-mission-inco' target='_blank'>American Society of Regional Anesthesia and Pain Medicine: Liposomal Bupivacaine, A Mission Incomplete</a> </li></ul>
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