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(Last updated: July 07, 2020)

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1

NEAREST SITE: 347 miles
City of Hope South Pasadena
South Pasadena,CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT01905046

Metformin to Reduce Breast Cancer Risk in Women with Increased Risk of Developing Breast Cancer

Testing for Atypia in Random Periareolar Fine Needle Aspiration (RPFNA) Cytology After 12 Months Metformin (1,1-Dimethylbiguanide Hydrochloride) Chemoprevention Versus Placebo Control in Premenopausal Women Scientific Title

Purpose
To determine whether metformin is better than a placebo at reducing breast cancer risk.
Who is this for?
Women who are at increased risk of breast cancer due to family history, BRCA mutation, or breast changes including atypical hyperplasia, DCIS or LCIS.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metformin, by mouth, daily for 2 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by mouth, daily for 1 year (may crossover to Group 1 for 1 year)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Women who have been diagnosed with atypical hyperplasia, DCIS or LCIS are at increased risk of developing breast cancer. </li> <li class="seamTextUnorderedListItem">Researchers are trying to find drugs (chemoprevention) that can reduce this risk. </li> <li class="seamTextUnorderedListItem">Findings from previous studies suggest that metformin, a drug used to treat diabetes, can reduce breast cancer risk in high-risk women.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01905046' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/about-cancer/causes-prevention/research/metformin' target='_blank'>NCI: Metformin Help Prevent Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.net/navigating-cancer-care/prevention-and-healthy-living/chemoprevention' target='_blank'>Cancer.net: Chemoprevention</a> </li></ul>
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2

NEAREST SITE: 1625 miles
Houston Methodist Hospital Willowbrook
Houston,TX

VISITS: Number of visits unavailable, over 1 year

PHASE: II-III

NCT ID: NCT02068092

Effect of Olive Oil on Breast Density in High-Risk Women

A Pilot Study of Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention In Women At High Risk Of Breast Cancer Scientific Title

Purpose
To evaluate the effect that hydroxytyrosol has on the breast tissue of women who are at high risk for developing breast cancer.
Who is this for?
Women who are at high risk for developing breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Baseline mammogram within 90 days prior to start of the study</li> <li class="seamTextUnorderedListItem">Hydroxytyrosol by mouth daily for 1 year</li> <li class="seamTextUnorderedListItem">Core needle biopsy</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Studies have shown that women with dense breast tissue are at increased risk for developing breast cancer.</li> <li class="seamTextUnorderedListItem">Laboratory studies have found that hydroxytyrosol--a major component of olive oil--is a powerful antioxidant with very low toxicity in the human body, even at high doses. </li> <li class="seamTextUnorderedListItem">Researchers think that hydroxytyrosol may reduce dense breast tissue.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02068092' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.sciencedaily.com/releases/2014/01/140122112401.htm' target='_blank'>Science Daily: Study article</a> </li></ul>
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3

NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda,MD

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT00028340

Using Breast Duct Cells to Assess Cancer Risk

Characterization of High Risk Breast Duct Epithelium by Cytology, Breast Duct Endoscopy, and cDNA Gene Expression Profile Scientific Title

Purpose
To compare the ductal cells and tissue by using ductal lavage and ductal endoscopy in women who are at high risk for breast cancer, breast cancer survivors and healthy volunteers.
Who is this for?
Women with breast cancer or high risk of developing breast cancer, healthy volunteer can also join the trial.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> All participants will receive the following procedures: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ductal lavage to collect milk duct cells</li> <li class="seamTextUnorderedListItem">Ductal endoscopy to observe the structure of the duct</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Most breast cancers begin in the cells that line the milk ducts in the breast. </li> <li class="seamTextUnorderedListItem">Previous studies have identified certain changes in the ductal cells and breast tissue that are associated with an increased risk of developing breast cancer. </li> <li class="seamTextUnorderedListItem">Ductal lavage and ductal endoscopy are techniques that allow researchers to study the cells and fluid that line the breast duct.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00028340' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/symptoms/testing/types/ductal' target='_blank'>breastcancer.org: Ductal Lavage</a> </li></ul>
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4

NEAREST SITE: 2569 miles
Columbia University Medical Center
New York,NY

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03069742

Web-based Decision Aids for High-Risk Women

Web-based Decision Aids for Breast Cancer Risk Assessment and Increasing Breast Cancer Chemoprevention in the Primary Care Setting: Randomized Controlled Trial Scientific Title

Purpose
To evaluate how well the RealRisks decision aid helps you to understand your breast cancer risk and your risk reduction options as well as develop an action plan with your provider.
Who is this for?
Women who are at high risk for breast cancer and receiving primary care at Columbia University Medical Center/ New York-Presbyterian Hospital.    Full eligibility criteria
Contact research site
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Contact Research Sites

  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RealRisks web-based decision aid tool</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard health education brochures</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RealRisks is a web-based decision aid for patients that is designed to work with the Breast Cancer Risk Navigation tool developed for doctors.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03069742' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://realrisks.dbmi.columbia.edu/' target='_blank'>RealRisks Website</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.facingourrisk.org/understanding-brca-and-hboc/information/risk-management/chemoprevention-breast-cancer/basics/overview.php' target='_blank'>Chemoprevention</a> </li></ul>
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