Browse Trials
Find Breast Cancer Clinical Trials That Are Right For You
The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.
Use the search box and filters to find a trial that’s right for you.
Currently viewing trials
(Last updated: March 18, 2023)
Brain Mets
BRCA1/2 (inherited)
Chemotherapy
Hormone Therapy
Leptomeningeal Disease
Radiation Oncology
Surgery
Surgery: Reconstruction
Targeted Therapy: All
Targeted Therapy: Anti-HER2 Therapy
Targeted Therapy: CDK Inhibitors
Targeted Therapy: PARP Inhibitors
Targeted Therapy: Tumor Mutations
Targeted Therapy: Other Targeted Therapy
Vaccines and Immunotherapy
Other Treatment
Activities
Complementary and Alternative Medicine
Decision Support
Diagnosing Breast Cancer
Genetics/Family History
Having Children
Lymphedema
Managing Side Effects
No Travel Required
Predicting Response to Treatment
Preventing Breast Cancer
Preventing Recurrence
Screening
Support/Education
Surveys/Interviews/Registries
AKT
ALK
AR
BARD1
BRCA1/2 (tumor)
BRIP1
CD205
CD70
CHEK2 or CHEK1
ESR1
FGFR
HER2/ERBB2
HLA
MET or C-Met
NTRK
PALB2
PIK3CA or PI3K
PTEN
RAD51
RAF (including BRAF)
RAS (KRAS or NRAS)
RB
ROS1
TP53
NEAREST SITE: 602 miles
Huntsman Cancer Institute
Salt Lake City,UT
VISITS: Number of visits unavailable
PHASE: II
NCT ID: NCT02694809
Duavee Hormone Therapy for Postmenopausal Women with DCIS
A Large-scale Multicenter Phase II Study Evaluating the Protective Effect of a Tissue Selective Estrogen Complex (TSEC) in Women With Newly Diagnosed Ductal Carcinoma in Situ Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Conjugated estrogens/bazedoxifene (Duavee®), by mouth, daily for 1 month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for conjugated estrogens/bazedoxifene (Duavee®), by mouth, daily for 1 month</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Conjugated estrogens/bazedoxifene (Duavee®) is a FDA approved hormone therapy used to treat symptoms of menopause such as hot flashes in women that do not have breast cancer.</li> <li class="seamTextUnorderedListItem">Because conjugated estrogens/bazedoxifene (Duavee®) is not approved in women with DCIS, its use in this study is experimental. </li> <li class="seamTextUnorderedListItem">Margins are the area around where DCIS was removed during surgery. A positive margin means DCIS cells were found in the margin after surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02694809' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/conjugated-estrogens-and-bazedoxifene-oral-route/description/drg-20061326' target='_blank'>Mayo Clinic: Conjugated Estrogens/Bazedoxifene (Duavee®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/types/ductal-carcinoma-in-situ' target='_blank'>Breastcancer.org: DCIS</a> </li></ul>
NEAREST SITE: 933 miles
Rocky Mountain Cancer Centers-Boulder
Boulder,CO
VISITS: 1 visit every 6 months for 5 years
PHASE: III
NCT ID: NCT04711109
Denosumab to Prevent Breast Cancer in Women With an Inherited BRCA1 Mutation
BRCA-P: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, International Phase 3 Study to Determine the Preventive Effect of Denosumab on Breast Cancer in Women Carrying a BRCA1 Germline Mutation Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Denosumab, by injection, every 6 months for up to 5 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for denosumab, by injection, every 6 months for up to 5 years</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Denosumab is a targeted therapy called a RANK ligand inhibitor. It is used to reduce the risk of bone fractures in people without cancer and to reduce new bone growth in people whose cancer has spread to their bones.</li> <li class="seamTextUnorderedListItem">Denosumab may also reduce the risk of developing breast cancer in women with an inherited (germline) BRCA1 mutation.</li> <li class="seamTextUnorderedListItem">Targets or mutations: BRCA1, BRCA 1</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04711109' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerpreventioninitiative.org/projects/prevention-of-breast-cancer-by-denosumab-in-women-carrying-a-brca1-or-brca2-mutation-brca-p-trial/' target='_blank'>Cancer Prevention Initiative: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a610023.html' target='_blank'>MedlinePlus: Denosumab</a> </li></ul>
NEAREST SITE: 1500 miles
University of Kansas Medical Center
Kansas City,KS
VISITS: 2 visits
PHASE: II
NCT ID: NCT04821141
Bazedoxifene and Estrogen Hormone Therapy to Reduce Risk Factors for Developing Breast Cancer
Randomized IIB Study of the Effect of Bazedoxifene Plus Conjugated Estrogens on Breast Imaging and Tissue Biomarkers in Peri or Post-Menopausal Women at Increased Risk for Development of Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bazedoxifene, by mouth, daily for 6 months</li> <li class="seamTextUnorderedListItem">Estrogen, by mouth, daily for 6 months</li> <li class="seamTextUnorderedListItem">Mammogram, 2 times within 6 months</li> <li class="seamTextUnorderedListItem">Fine needle aspiration biopsy, 2 times within 6 months</li> <li class="seamTextUnorderedListItem">Blood tests, 2 times within 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mammogram, 2 times within 6 months</li> <li class="seamTextUnorderedListItem">Fine needle aspiration biopsy, 2 times within 6 months</li> <li class="seamTextUnorderedListItem">Blood tests, 2 times within 6 months</li> </ul> <p class="seamTextPara"> followed 6 months later by (optional): </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bazedoxifene, by mouth, daily for 6 months</li> <li class="seamTextUnorderedListItem">Estrogen, by mouth, daily for 6 months</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Bazedoxifene is a type of hormone therapy called a selective estrogen receptor modulator (SERM). SERMs work by blocking the activity of estrogen. It may help reduce the risk of breast cancer.</li> <li class="seamTextUnorderedListItem">Estrogen is a hormone used to treat women experiencing hot flashes.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04821141' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2022-03864&r=1#:~:text=Giving%20bazedoxifene%20with%20conjugated%20estrogens,increased%20risk%20for%20breast%20cancer.' target='_blank'>National Cancer Institute: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a614004.html' target='_blank'>Medline Plus: Bazedoxifene and Estrogen</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cdc.gov/cancer/breast/basic_info/mammograms.htm' target='_blank'>Centers for Disease Control and Prevention: Mammogram</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/screening-tests-and-early-detection/breast-biopsy/fine-needle-aspiration-biopsy-of-the-breast.html#:~:text=During%20a%20fine%20needle%20aspiration,needle%20biopsy%20is%20often%20preferred).' target='_blank'>American Cancer Society: Fine Needle Aspiration Biopsy</a> </li></ul>
NEAREST SITE: 1615 miles
Mayo Clinic
Rochester,MN
VISITS: Number of visits unavailable
PHASE: II-III
NCT ID: NCT04570956
Tamoxifen Hormone Therapy for Women With Atypical Hyperplasia or LCIS
A Phase IIB Randomized Trial of Oral Tamoxifen vs. Topical 4-hydroxytamoxifen Gel vs. Control in Women With Atypical Hyperplasia or Lobular Carcinoma In Situ Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for tamoxifen (Nolvadex®), by mouth, daily</li> <li class="seamTextUnorderedListItem">4-hydroxytamoxifen (TamGel®), gel rubbed on the breast, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for tamoxifen (Nolvadex®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Placebo for 4-hydroxytamoxifen (TamGel®), gel rubbed on the breast, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">2 biopsies</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tamoxifen (Nolvadex®) is a type of hormone therapy called a selective estrogen receptor modulator (SERM). SERMs work by blocking the activity of estrogen.</li> <li class="seamTextUnorderedListItem">4-hydroxytamoxifen (TamGel®) is a gel version of tamoxifen.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04570956' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/breast-cancer/in-depth/breast-cancer/art-20045353#:~:text=Tamoxifen%20is%20used%20to%20reduce,score%20is%20greater%20than%201.7%25.' target='_blank'>Mayo Clinic: Tamoxifen for Breast Cancer Prevention</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/tamoxifen' target='_blank'>Breastcancer.org: Tamoxifen (Nolvadex®)</a> </li></ul>
NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN
VISITS: Number of visits unavailable
PHASE: II
NCT ID: NCT05557877
Low-Dose Aspirin to Prevent Breast Cancer After Having a Baby
Targeted Prevention of Postpartum-Related Breast Cancer Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Blood tests</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Low-dose aspirin, by mouth, daily</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Low-dose aspirin, a non-steroidal anti-inflammatory drug, may reduce inflammation in blood and tissue which may prevent breast cancer after having a baby.</li> <li class="seamTextUnorderedListItem">Benign breast disease is non-cancerous breast disease.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05557877' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-aspirins-role-in-preventing-and-stopping-the-spread-of-cancer/' target='_blank'>Mayo Clinic: Aspirin and Cancer Prevention</a> </li></ul>
NEAREST SITE: 2054 miles
University of Michigan Rogel Cancer Center
Ann Arbor,MI
VISITS: Number of visits unavailable
PHASE: NA
NCT ID: NCT05700006
Effects of Hormone Therapy vs. No Hormone Therapy for Breast Cancer and Breast Cancer Prevention on Aging and the Microbiome
An Observational Study of Women With Breast Cancer Examining the Effect of Endocrine Therapy on Aging Scientific Title
- What's involved?
- What's being studied?
- How can I learn more?
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<p class="seamTextPara"> You will be assigned to 1 of 3 groups depending on your situation: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Over 65 and Planning to Receive Hormone Therapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Physician's choice of anastrozole (Arimidex®), exemestane (Aromasin®), or letrozole (Femara®)</li> <li class="seamTextUnorderedListItem">3 stool samples, questionnaires, blood draws</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Over 65 and Not Planning to Receive Hormone Therapy (Control Group)</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3 stool samples, questionnaires, blood draws</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Under 65 and Planning to Receive Hormone Therapy</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Physician's choice of anastrozole (Arimidex®), exemestane (Aromasin®), or letrozole (Femara®)</li> <li class="seamTextUnorderedListItem">3 stool samples, questionnaires, blood draws</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The microbiome is the collection of microorganisms (bacteria) living in your digestive tract.</li> <li class="seamTextUnorderedListItem">Anastrozole (Arimidex®), exemestane (Aromasin®), and letrozole (Femara®) are types of hormone therapy called aromatase inhibitors. Aromatase inhibitors block some production of estrogen that helps cancer grow.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05700006' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/arimidex' target='_blank'>Breastcancer.org: Anastrozole (Arimidex®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/aromasin' target='_blank'>Breastcancer.org: Exemestane (Aromasin®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/femara' target='_blank'>Breastcancer.org: Letrozole (Femara®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.insideprecisionmedicine.com/topics/oncology/breast-cancer/probiotic-bacteria-may-improve-efficacy-of-endocrine-targeted-therapies-for-breast-cancer/' target='_blank'>Inside Precision Medicine: Breast Cancer Treatments and the Microbiome</a> </li></ul>
