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Find Breast Cancer Clinical Trials That Are Right For You

The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.

Use the search box and filters to find a trial that’s right for you.


Currently viewing trials
(Last updated: December 03, 2024)

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Treatment

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BRCA1/2 (inherited)

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Surgery: Reconstruction

Targeted Therapy: All

Targeted Therapy: ADC

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Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

Targeted Therapy: Other Targeted Therapy

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AKT

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BARD1

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CD205

CD70

CHEK2 or CHEK1

dMMR/MSI-H

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FGFR

HER2/ERBB2

HLA

MET or C-Met

NTRK

PALB2

PIK3CA or PI3K

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RAF (including BRAF)

RAS (KRAS or NRAS)

RB

ROS1

TP53

1

NEAREST SITE: 602 miles
Huntsman Cancer Institute at University of Utah
Salt Lake City,UT

VISITS: Coincides with surgery

PHASE: II

NCT ID: NCT05464082

Predict, Prevent, and Treat Early Metastatic Recurrence of HR Low, HER2-/HER2 Low or Triple Negative Breast Cancer

Towards Functional Precision Oncology to Predict, Prevent, and Treat Early Metastatic Recurrence of Triple Negative Breast Cancer Scientific Title

Purpose
To study ways to predict, prevent, and treat early metastatic recurrence.
Who is this for?
People with stage I, stage II, or stage III hormone receptor (ER and/or PR) low, HER2 negative (HER2-) or HER2 low or triple negative (ER-, PR-, HER2-) breast cancer. You must have not yet received treatment and be planning to receive surgery and chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will provide the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tumor samples</li> <li class="seamTextUnorderedListItem">Blood tests</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Precision oncology is treatment based on specific information from your tumor.</li> <li class="seamTextUnorderedListItem">The tumor samples will be used to complete tests to determine which treatments may be most effective.</li> <li class="seamTextUnorderedListItem">If your cancer comes back (recurrence) after surgery and chemotherapy, your doctor will receive information to help make treatment decisions.</li> <li class="seamTextUnorderedListItem">In this trial, HER2 low is defined as IHC 1+ or 2+ and ISH-.</li> <li class="seamTextUnorderedListItem">In this trial, hormone receptor (HR) low is defined as 1-10% of cells that are ER+ and PR+.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05464082' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/tests-procedures/precision-medicine-breast-cancer/about/pac-20385240' target='_blank'>Mayo Clinic: What is Precision Oncology?</a> </li></ul>
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2

NEAREST SITE: 2260 miles
Allegheny General Hospital
Pittsburgh,PA

VISITS: 3-4 visits per week for 3 months

PHASE: NA

NCT ID: NCT05747209

Exercise to Improve Mobility and Strength After Breast Cancer Treatment

Prospective Study of an EXErcise Regimen Designed to Improve Functional Mobility, Body Composition, and Strength After Treatment for Breast Cancer Scientific Title

Purpose
To learn how a group resistance training plan can improve body mobility and strength after breast cancer treatment.
Who is this for?
Women with stage 0 (DCIS), stage I, stage II, or some stage III breast cancer who have completed treatment. You must not have received treatment with chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">In-person group resistance training exercise regimen, 3-4 times per week for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The exercise regimen is a standard of care regimen that includes full body resistance training with lunges, squats, and dead lifts.</li> <li class="seamTextUnorderedListItem">Warm-up exercises focus on mobility, flexibility and core activation to reduce the risk of injury.</li> <li class="seamTextUnorderedListItem">Each workout will take approximately 45 minutes.</li> <li class="seamTextUnorderedListItem">Physical activity has been repeatedly associated with a lower risk of cancer incidence, improved outcomes after cancer treatment, and improved overall survival.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05747209' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/exercise' target='_blank'>Breastcancer.org: Exercise</a> </li></ul>
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3

NEAREST SITE: 2437 miles
AdventHealth
Orlando,FL

VISITS: 4 visits within 6 months

PHASE: NA

NCT ID: NCT06078761

Healthy Eating and Active Lifestyle (HEAL) Education Program to Prevent Breast Cancer Recurrence

A Prospective Study of the Healthy Eating and Active Lifestyle (HEAL BC): Breast Cancer Program on Survivorship Outcomes Scientific Title

Purpose
To study the impact of the Healthy Eating and Active Lifestyle (HEAL) program on recurrence (cancer coming back), stress, body measurements, lifestyle behaviors, mental health, and quality of life.
Who is this for?
People with stage I, stage II, or stage III breast cancer who have completed treatment and receive care at AdventHealth Medical Group in Orlando, FL.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">HEAL education sessions, virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Weight and blood pressure measurements, 4 times within 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 4 times within 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Healthy Eating and Active Lifestyle (HEAL) program is a lifestyle program for cancer survivors with the goal of decreasing risk of cancer recurrence (cancer coming back) and preventing, treating, and potentially reversing other long-term diseases.</li> <li class="seamTextUnorderedListItem">The program includes plant-based nutrition, yoga, and mindfulness.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06078761' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.adventhealthcancerinstitute.com/HEALBreast' target='_blank'>AdventHealth: HEAL Breast Cancer Program</a> </li></ul>
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4

NEAREST SITE: 2517 miles
Abramson Cancer Center of the University of Pennsylvania
Philadelphia,PA

VISITS: 1 visit a year, for 1 to 5 years

PHASE: NA

NCT ID: NCT02732171

Looking for Disseminated Tumor Cells in Bone Marrow After Breast Cancer Treatment to Guide Decisions About Additional Treatment

PENN-Surveillance Markers of Utility for Recurrence After (Neo)Adjuvant Therapy for Breast Cancer (SURMOUNT) Scientific Title

Purpose
To look for, study, and treat disseminated tumor cells (DTCs) in the bone marrow of people with high-risk, early-stage breast cancer.
Who is this for?
People who have completed treatment for stage I, stage II, or stage III breast cancer within the last five years. Additionally, your cancer must be considered high risk for recurrence. For this trial, high risk is defined as node-positive, triple-negative, Oncotype score 25 or higher for ER+, HER2- disease, or the presence of residual disease after neoadjuvant (before surgery) chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive a bone marrow aspiration test (bone marrow biopsy), then your bone marrow sample will be tested for disseminated tumor cells.</p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Studies have found that people who have disseminated tumor cells (DTCs) in their bone marrow are at greater risk of having a breast cancer recurrence than people without DTCs. </li> <li class="seamTextUnorderedListItem">A bone marrow aspiration can be used to look for DTCs.</li> <li class="seamTextUnorderedListItem">If you are found to have DTCs in your bone marrow, you will have an opportunity to enroll in a separate clinical trial that is evaluating the effectiveness of using a therapy that targets DTCs to prevent recurrence.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02732171' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pennmedicine.org/cancer/cancer-research/translating-research-to-practice/breast-cancer-tce/surmount-study' target='_blank'>Penn Medicine: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nlm.nih.gov/medlineplus/ency/article/003658.htm' target='_blank'>MedLinePlus: Bone Marrow Aspiration</a> </li></ul>
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5

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: 3 visits every week for 4 months, then 1 visit every month for 8 months

PHASE: NA

NCT ID: NCT04720209

Exercise to Decrease Inflammation in Fat and Prevent Recurrence for Women with Stage 0-III Breast Cancer

Taking AIM at Breast Cancer: Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer Survivors Scientific Title

Purpose
To determine if an exercise program will decrease inflammation in fat tissue and reduce the risk of cancer recurrence (cancer coming back).
Who is this for?
Women with stage 0 (DCIS), stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who have completed treatment, have obesity (BMI >30), and exercise less than 1 hour every week.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Circuit-style aerobic and resistance exercise (CARE), 3 times every week for 4 months</li> <li class="seamTextUnorderedListItem">DEXA scan, 1 time</li> <li class="seamTextUnorderedListItem">Fat biopsy, 3 times (optional)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Traditional aerobic resistance exercise (TARE), 3 times every week for 4 months</li> <li class="seamTextUnorderedListItem">DEXA scan, 1 time</li> <li class="seamTextUnorderedListItem">Fat biopsy, 3 times (optional)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stretching exercise, at home, 4 months</li> </ul> <p class="seamTextPara"> followed by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Circuit-style aerobic and resistance exercise (CARE), 3 times every week for 4 months (optional)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise may reduce inflammation in fat tissue.</li> <li class="seamTextUnorderedListItem">Reducing inflammation in fat tissue may decrease the risk of cancer coming back that is related to being overweight or obese.</li> <li class="seamTextUnorderedListItem">Circuit-style exercise (group 1) means alternating between different exercises that use different muscle groups.</li> <li class="seamTextUnorderedListItem">A DEXA scan measures fat, muscle, and bone density.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04720209' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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