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Find Breast Cancer Clinical Trials That Are Right For You

The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.

Use the search box and filters to find a trial that’s right for you.

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(Last updated: June 26, 2025)

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NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA

VISITS: Coincides with routine care

PHASE: NA

NCT ID: NCT06215469

Portable Scalp Cooling System to Reduce Hair Loss During Chemotherapy for Stage I-III Breast Cancer

Amma™ Portable Scalp Cooling System (PSCS) Study: A Post-market Study to Assess the Ability of the Portable Scalp Cooling System (PSCS) to Prevent Hair Loss in Women Receiving Specific Chemotherapy Regimens for Early-stage Breast Cancer (Cooler Heads) Scientific Title

Purpose

To study the ability of the AMMA Portable Scalp Cooling System to reduce hair loss in people receiving chemotherapy.

Who is this for?

People with stage I, stage II, or stage III breast cancer who are planning to receive paclitaxel (Taxol®) or docetaxel (Taxotere®) chemotherapy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Photographs of your hair</li> <li class="seamTextUnorderedListItem">Wear the AMMA Portable Scalp Cooling System 30 minutes before, during, and 2.5 hours after every chemotherapy visit</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li> <li class="seamTextUnorderedListItem">Photographs of your hair</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Many chemotherapy medications cause hair loss.</li> <li class="seamTextUnorderedListItem">The AMMA Portable Scalp Cooling System is a small refrigeration device that is designed to reduce hair loss. It circulates liquid coolant at low pressure through a cooling cap on your head.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06215469' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://coolerheads.com/#how-amma-works' target='_blank'>Amma Portable Scalp Cooling System</a> </li></ul>

NEAREST SITE: 3 miles
Zuckerberg San Francisco General
San Francisco,CA

VISITS: Up to 2 visits every month for 6 months

PHASE: NA

NCT ID: NCT06633926

Nutrition, Yoga, and Healing Touch Program to Improve Quality of Life for Stage I-III Breast Cancer

Integrative Approaches for Cancer Survivorship: A Multi-Site Feasibility and Acceptability Study (Aim 2) (IACS3) Scientific Title

Purpose

To study if the Ayurveda nutrition, yoga, and healing touch program improves quality of life and cancer-associated symptoms.

Who is this for?

People with stage I, stage II, or stage III breast cancer who completed treatment less than 3 years ago. You must have received chemotherapy. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care</li> <li class="seamTextUnorderedListItem">Ayurveda (nutrition, yoga, healing touch) program, in person, 2 times every month for 6 months</li> <li class="seamTextUnorderedListItem">Virtual meeting, monthly for 6 months (optional)</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care</li> <li class="seamTextUnorderedListItem">Health education program, virtual, 2 times every month for 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Ayurveda program includes nutrition education, lifestyle practices, yoga, and therapeutic touch to help the body and mind feel balanced.</li> <li class="seamTextUnorderedListItem">The health education program includes interactive videos based on the latest science in cancer survivorship.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06633926' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 3 miles
Kaiser Permanente-San Francisco
San Francisco,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05896189

Computer Games to Improve Thinking for People with Stage I-III Breast Cancer

Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors: A Multi-Center Randomized Double-Blinded Controlled Trial Scientific Title

Purpose

To study how well computer games improve thinking problems.

Who is this for?

People with stage I, stage II, or stage III breast cancer who have completed treatment 6 months to 5 years ago. You must be experiencing problems thinking. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Computer games designed to improve thinking skills</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times in 9 months</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General computer games</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times in 9 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognition is your ability to think.</li> <li class="seamTextUnorderedListItem">Problems with thinking, called cognitive impairment, can happen during and after breast cancer treatment.</li> <li class="seamTextUnorderedListItem">These problems can last for years and can affect a person's ability to work or participate in social activities.</li> <li class="seamTextUnorderedListItem">The computer games may help re-organize the connections of nerve cells in the brain to improve thinking ability.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05896189' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 336 miles
University of California at Los Angeles
Los Angeles,CA

VISITS: 1 visit

PHASE: NA

NCT ID: NCT04297020

Studying the Effects of Anti-Estrogen Therapy on the Brain of Women with Stage I-III Breast Cancer

Brain Health in Breast Cancer Survivors: Interaction of Menopause and Endocrine Therapy Scientific Title

Purpose

To see if anti-estrogen therapy affects brain health.

Who is this for?

Women between the ages of 35 and 65 with stage I, stage II, or stage III breast cancer who are taking hormone therapy after surgery. This trial is also enrolling women who have never been diagnosed with breast cancer. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 Brain fMRI (functional MRI)</li> <li class="seamTextUnorderedListItem">Cognitive testing</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This trial will use an advanced brain MRI technique called functional MRI (fMRI).</li> <li class="seamTextUnorderedListItem">fMRI measures changes in blood flow that happen during mental activity. </li> <li class="seamTextUnorderedListItem">Research suggests that the cognitive issues experienced by some women who receive treatment for breast cancer--also called <q>chemo brain</q>--may actually be caused by anti-estrogen therapy and not chemotherapy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04297020' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medscape.com/viewarticle/932091' target='_blank'>MedScape: In Breast Cancer, Is Chemobrain Really Endocrine Brain?</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Functional_magnetic_resonance_imaging' target='_blank'>Wikipedia: Functional MRI</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.radiologyinfo.org/en/info.cfm?pg=fmribrain' target='_blank'>RadiologyInfo.org: fMRI</a> </li></ul>

NEAREST SITE: 336 miles
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT05595499

Fisetin to Improve Physical Function in Older Women After Chemotherapy

A Phase II Randomized Double-Blind Placebo-Controlled Study of Fisetin to Improve Physical Function in Frail Older Breast Cancer Survivors Scientific Title

Purpose

To study whether fisetin improves physical function in older women after treatment with chemotherapy.

Who is this for?

Women who were at least 65 years old and postmenopausal when diagnosed with stage I, stage II, or stage III breast cancer. You must have completed chemotherapy within the last year. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fisetin, by mouth, 2 months</li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for fisetin, by mouth, 2 months</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> <li class="seamTextUnorderedListItem">Walking test</li> <li class="seamTextUnorderedListItem">Grip strength test</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fisetin is a naturally occurring substance that is found in strawberries and other foods.</li> <li class="seamTextUnorderedListItem">Fisetin eliminates cells that have stopped dividing but have not died.</li> <li class="seamTextUnorderedListItem">Chemotherapy causes a build-up of these cells which may cause inflammation. damage nearby healthy cells, and cause reduced physical function.</li> <li class="seamTextUnorderedListItem">Improving physical function is also called improving frailty.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05595499' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://restorativemedicine.org/digest/fisetin-powerful-polyphenol-supports-healthy-aging/' target='_blank'>Association for the Advancement of Restorative Medicine: Fisetin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.urmc.rochester.edu/news/story/frailty-in-cancer-patients-young-and-old-is-linked-to-inflammation' target='_blank'>University of Rochester: Frailty and Breast Cancer</a> </li></ul>

NEAREST SITE: 336 miles
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles,CA

VISITS: 2 visits within 2 months

PHASE: II

NCT ID: NCT04290897

Oxaloacetate to Reduce Side Effects After Treatment in People with DCIS and Stage I-III Breast Cancer

A Phase II Single Arm Trial Evaluating the Safety and Efficacy of Anhydrous Enol-Oxaloacetate on Improving Cognitive Complaints in Breast Cancer Survivors Scientific Title

Purpose

To study the safety and ability of oxaloacetate to reduce brain problems, fatigue, sleep problems, and depression after breast cancer treatment.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or some stage III breast cancer who have completed treatment. You must have been diagnosed no more than 5 years ago. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Oxaloacetate, by mouth, daily for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Oxaloacetate is a natural substance found in the body and is available as a nutritional supplement.</li> <li class="seamTextUnorderedListItem">Oxaloacetate may reduce inflammation in the brain that could contribute to brain problems (cognition) after cancer treatments.</li> <li class="seamTextUnorderedListItem">Cognition is your ability to think.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04290897' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/side-effects/memory#:~:text=Cancer%20treatments%20such%20as%20chemotherapy,during%20or%20after%20cancer%20treatment.' target='_blank'>National Cancer Institute: Memory or Concentration Problems and Cancer Treatment</a> </li></ul>

NEAREST SITE: 336 miles
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT06113016

Fisetin Supplement and Exercise to Improve Health After Treatment for Postmenopausal Women with Stage I-III Breast Cancer

A Phase II Randomized Placebo-Controlled Study of Fisetin and Exercise to Prevent Frailty in Breast Cancer Survivors (PROFFi) Scientific Title

Purpose

To study how well fisetin, a nutritional supplement, and exercise prevent frailty (weakness).

Who is this for?

Postmenopausal women with stage I, stage II, or stage III breast cancer who have received chemotherapy within the last year. Full eligibility criteria

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You will be randomly assigned to 1 of 4 groups: Group 1: Fisetin and Exercise Education Materials <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fisetin, by mouth, 3 days every 2 weeks for 4 months</li> <li class="seamTextUnorderedListItem">Handout on the importance of physical activity</li> <li class="seamTextUnorderedListItem">Blood samples</li> <li class="seamTextUnorderedListItem">Physical tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Fisetin and Exercise Program <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fisetin, by mouth, 3 days every 2 weeks for 4 months</li> <li class="seamTextUnorderedListItem">Supervised exercise training, 3 sessions every week for 4 months</li> <li class="seamTextUnorderedListItem">Blood samples</li> <li class="seamTextUnorderedListItem">Physical tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 3: Placebo and Exercise Program <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for fisetin, by mouth, 3 days every 2 weeks for 4 months</li> <li class="seamTextUnorderedListItem">Supervised exercise training, 3 sessions every week for 4 months</li> <li class="seamTextUnorderedListItem">Blood samples</li> <li class="seamTextUnorderedListItem">Physical tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 4: Placebo and Exercise Education Materials <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for fisetin, by mouth, 3 days every 2 weeks for 4 months</li> <li class="seamTextUnorderedListItem">Handout on the importance of physical activity</li> <li class="seamTextUnorderedListItem">Blood samples</li> <li class="seamTextUnorderedListItem">Physical tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Frailty is marked by low strength, low energy, slowed walking speed, low physical activity, and/or unintentional weight loss.</li> <li class="seamTextUnorderedListItem">In this study, frailty is measured by walking speed.</li> <li class="seamTextUnorderedListItem">Fisetin is a natural substance found in strawberries and other foods and is available as a nutritional supplement.</li> <li class="seamTextUnorderedListItem">Fisetin may help reduce inflammation and improve outcomes in people with breast cancer who are exercising.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06113016' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
West Hollywood,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT04722341

Time-Restricted Eating to Reduce Treatment Side Effects for People with Stage II-III Breast Cancer

Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators Scientific Title

Purpose

To study the effects (good and bad) and anti-cancer activity of time-restricted eating (TRE) during treatment before surgery.

Who is this for?

People with stage II or stage III breast cancer who are planning to receive chemotherapy before surgery (neoadjuvant). Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Time-restricted eating (TRE) schedule, 8 hour daily eating period, 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Regular eating schedule, 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fasting may protect healthy cells from chemotherapy and radiation side effects.</li> <li class="seamTextUnorderedListItem">Time-restricted eating (TRE) involves eating within a period of 10 hours or less, followed by fasting for at least 14 hours daily.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04722341' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/can-fasting-reduce-recurrence-risk' target='_blank'>Breastcancer.org: Can Fasting 13 Hours or More at Night Reduce Recurrence Risk?</a> </li></ul>

NEAREST SITE: 348 miles
USC / Norris Comprehensive Cancer Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT06297265

Manual Breast Massage to Reduce Treatment Side Effects for Women with Stage 0-III Breast Cancer

Feasibility and Effects of Manual Lymphatic Drainage (MLD) Breast Massage in Breast Cancer Patients Undergoing Adjuvant Radiation Therapy Scientific Title

Purpose

To study the ability of manual lymphatic drainage breast massage to reduce treatment related side effects.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who have received a lumpectomy and are planning to receive radiation. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Manual lymphatic drainage breast massage, 2 times every week for 2-3 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lumpectomy and radiation can lead to side effects including swelling called lymphedema, pain, reduced quality of life, and poor body image. </li> <li class="seamTextUnorderedListItem">Manual lymphatic drainage is a gentle massage technique used to reduce swelling. It may be a safe and effective way to reduce treatment related side effects after lumpectomy and radiation.</li> <li class="seamTextUnorderedListItem">Manual means you will be giving yourself the massage.</li> <li class="seamTextUnorderedListItem">Each massage is 30-60 minutes.</li> <li class="seamTextUnorderedListItem">You will be asked to complete the massage during radiation and for 1 month after radiation.</li> <li class="seamTextUnorderedListItem">A lumpectomy is sometimes called a partial mastectomy.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06297265' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 353 miles
City of Hope Medical Center
Duarte,CA

VISITS: 5 visits in 2 years

PHASE: III

NCT ID: NCT06763328

Metformin for Insulin Resistance After Chemotherapy for Women with Stage I-III Breast Cancer

Metformin (Dimethylbiguanide) and Insulin Resistance in Women Completing Neoadjuvant and/or Adjuvant Cytotoxic Treatment of Stage I-III Breast Cancer Scientific Title

Purpose

To study the ability of metformin to help treat insulin resistance after completing chemotherapy.

Who is this for?

Women with stage I, stage II, or stage III estrogen receptor negative (ER-) breast cancer who completed chemotherapy between 1 month and 3 years ago. You must not have diabetes. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Metformin with Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Metformin, by mouth, daily for 1 year</li> <li class="seamTextUnorderedListItem">Healthy diet and exercise handouts</li> <li class="seamTextUnorderedListItem">Blood samples, 5 times in 2 years </li> </ul> Group 2: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Healthy diet and exercise handouts</li> <li class="seamTextUnorderedListItem">Blood samples, 5 times in 2 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Insulin resistance occurs when cells stop responding to insulin and is a risk factor for developing diabetes and heart disease. </li> <li class="seamTextUnorderedListItem">Higher levels of insulin are related to aggressive breast cancer. </li> <li class="seamTextUnorderedListItem">Metformin decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body's use of the glucose. </li> <li class="seamTextUnorderedListItem">Giving metformin with usual care may be more effective than usual care alone in preventing or reversing insulin resistance in women with stage I-III breast cancer after chemotherapy.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06763328' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 353 miles
City of Hope Medical Center
Duarte,CA

VISITS: 3 visits in 3 months

PHASE: II

NCT ID: NCT06538389

CBD for Joint Pain During Hormone Therapy for Women with Stage 0-III Breast Cancer

High Cannabidiol (CBD) Standardized Extract for Aromatase Inhibitor-Induced Arthralgia - A Randomized Controlled Double Blind Clinical Trial Scientific Title

Purpose

To study the ability of BC-001, a cannabidiol (CBD) plant extract, to reduce joint pain during hormone therapy.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or some stage III hormone receptor positive (ER+ and/or PR+) breast cancer who have completed treatment. You must be receiving an aromatase inhibitor and experiencing joint pain. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BC-001, by mouth, daily, up to 3 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Placebo <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for BC-001, by mouth, daily, up to 3 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Women on aromatase inhibitor (AI) therapy may experience joint stiffness, pain and arthritis symptoms as a side effect of the medication.</li> <li class="seamTextUnorderedListItem">Some women stop AI therapy due to these side effects and do not receive the maximum benefit from the medication.</li> <li class="seamTextUnorderedListItem">BC-001 is an experimental cannabidiol (CBD) plant extract.</li> <li class="seamTextUnorderedListItem">CBD is derived from the same plant family as marijuana but is not associated with a <q>high</q> or mind-altering effect and is not habit-forming.</li> <li class="seamTextUnorderedListItem">CBD might decrease inflammation in joint tissues and may help reduce chronic pain.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06538389' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 374 miles
Chao Family Comprehensive Cancer Center, University of California Irvine
Orange,CA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT06580002

Riluzole to Improve Cognition After Treatment for People with Stage I-III Breast Cancer

Repurposing Riluzole for Augmenting Brain-Derived Neuropathic Factor (BDNF) Levels and Cognitive Function in Breast Cancer Patients Experiencing Cancer-Related Cognitive Impairment: an Interventional Pilot Clinical Trial Scientific Title

Purpose

To study if riluzole (Rilutek®) changes the amount of brain derived neurotrophic factor (BDNF) in your body, which is related to changes in cognition (ability to think).

Who is this for?

People with stage I, stage II, or stage III breast cancer who have cognitive (thinking) issues. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Riluzole (Rilutek®), by mouth, daily for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Placebo <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for riluzole, by mouth, daily for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognition is your ability to think.</li> <li class="seamTextUnorderedListItem">Brain derived neurotrophic factor (BDNF) is a protein that is involved with thinking (cognition) and learning.</li> <li class="seamTextUnorderedListItem">Changing the amount of brain derived neurotrophic factor (BDNF) in your body may improve your cognition.</li> <li class="seamTextUnorderedListItem">Riluzole (Rilutek®) is a drug used to treat ALS (Lou Gehrig's disease), but it may also be helpful to improve cognition. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">This trial is also available in Chinese, Korean, Vietnamese, and Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06580002' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/riluzole-oral-route/description/drg-20065853' target='_blank'>Mayo Clinic: Riluzole (Rilutek®)</a> </li></ul>

NEAREST SITE: 533 miles
OHSU Knight Cancer Institute
Portland,OR

VISITS: 4 visits within 6 months

PHASE: II

NCT ID: NCT06049355

Exercise Program for Couples to Improve Physical and Mental Health During Radiation for Stage I-III Breast Cancer

EMBark on RAdiation Therapy With a Clinic-based Exercise Program: EXERCISING TOGETHER (EMBRACE) Scientific Title

Purpose

To study how well the Exercising Together program prevents declines in physical and mental health in couples where one partner is receiving radiation.

Who is this for?

People with stage I, stage II, or stage III breast cancer who are planning to receive or receiving radiation and live with a partner who is willing to participate in the study. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercising Together program, 6 months</li> <li class="seamTextUnorderedListItem">Blood samples</li> <li class="seamTextUnorderedListItem">Physical tests, 4 times within 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 4 times within 6 months</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Educational materials about exercise</li> <li class="seamTextUnorderedListItem">Blood samples</li> <li class="seamTextUnorderedListItem">Physical tests, 4 times within 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 4 times within 6 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Treatments for cancer including radiation can cause side effects such as fatigue and can put a strain on relationships. </li> <li class="seamTextUnorderedListItem">Exercising Together is an exercise program for both people in the relationship that adds communication, collaboration, and support to the exercise program and is designed to strengthen the relationship and increase the benefits of exercise. </li> <li class="seamTextUnorderedListItem">The Exercising Together program may improve the mental and physical health of couples when one person is receiving radiation treatment for cancer.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06049355' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 650 miles
Mayo Clinic in Arizona
Phoenix,AZ

VISITS: At least 2 visits within 6 months

PHASE: NA

NCT ID: NCT04816006

Exercise to Improve Thinking Ability After Treatment for Women with Stage I-III Breast Cancer

Enhancing Cognitive Function in Breast Cancer Survivors Through Community-based Exercise Training (BRAIN) Scientific Title

Purpose

To study whether an exercise program improves cognitive function (the ability to think).

Who is this for?

Postmenopausal women with stage I, stage II, or some stage III breast cancer who have completed treatment between 3 months ago and 2 years ago. You must regularly perform at least 20 minutes of exercise up to 2 days every week. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Supervised exercise sessions, 20 sessions within 6 months</li> <li class="seamTextUnorderedListItem">MRI scan, 2 times within 6 months</li> <li class="seamTextUnorderedListItem">Walking test</li> <li class="seamTextUnorderedListItem">Wear an accelerometer</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education sessions, in-person or virtual, monthly for 9 months</li> <li class="seamTextUnorderedListItem">Education resources and 1 year subscription to Mayo Clinic Health Letter</li> <li class="seamTextUnorderedListItem">MRI scan, 2 times within 6 months</li> <li class="seamTextUnorderedListItem">Walking test</li> <li class="seamTextUnorderedListItem">Wear an accelerometer</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Free fitness center membership, 6 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Problems with thinking (cognition) affect daily functioning, quality of life, and long-term health. </li> <li class="seamTextUnorderedListItem">Aerobic exercise may help improve these problems and is generally considered safe, tolerable, and accessible.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, treadmill walking is the primary mode of exercise. However, you will be permitted to use other cardiovascular equipment (e.g., elliptical machines, stationary bicycles) as prescribed by your exercise trainer.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, the sessions will cover cancer support and discussion of cancer-related wellness topics such as stress management and coping.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, you will receive a free 6 month fitness membership after the study.</li> <li class="seamTextUnorderedListItem">An accelerometer is a device that measures how fast you walk.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04816006' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 887 miles
Presbyterian Southern Outpatient Rehab
Rio Rancho,NM

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05983380

Hand Exercises for Lymphedema for Women with Stage 0-III Breast Cancer

The Effect of Hand Mobility and Grip Strengthening Exercises on Upper Limb Volume, Quality of Life, and Hand Function in Breast Cancer Survivors Scientific Title

Purpose

To determine if hand mobility and grip strengthening exercises with usual care will reduce swelling and improve quality of life, hand mobility, and grip strength.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who completed treatment in the past 10 years and have untreated lymphedema. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hand exercises</li> <li class="seamTextUnorderedListItem">Compression, exercise, information about skin hygiene, and massage</li> <li class="seamTextUnorderedListItem">Measurements, 3 times within 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times within 2 months</li> </ul> Group 2: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Compression, exercise, information about skin hygiene, and massage</li> <li class="seamTextUnorderedListItem">Measurements, 3 times within 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times within 2 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that develops as a side effect of breast cancer treatments like surgery and radiation therapy.</li> <li class="seamTextUnorderedListItem">Lymphedema can affect arm function and quality of life.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05983380' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 941 miles
University of Colorado Hospital
Aurora,CO

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05138510

Sexual Health in People with DCIS and Stage I-IV Breast Cancer

Sexuality and Breast Cancer: Developing Appropriate Education for Women Going Through Treatment Scientific Title

Purpose

To identify the sexual health needs among women with breast cancer at the time of diagnosis and throughout treatment.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, stage III, or stage IV (metastatic) breast cancer who have received care at the University of Colorado Hospital since September 2019. Full eligibility criteria

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You will participate the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Virtual focus group</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Providers will lead the virtual focus groups over Zoom.</li> <li class="seamTextUnorderedListItem">Focus group findings will be used to create appropriate educational material that will address the sexual health needs of people with breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05138510' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/sex-intimacy' target='_blank'>Breastcancer.org: Sexual Health During and After Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/types/metastatic/sexuality' target='_blank'>Breastcancer.org: Sexuality and Metastatic Breast Cancer</a> </li></ul>

NEAREST SITE: 941 miles
Outpatient CTRC
Aurora,CO

VISITS: 5 visits within 6 months

PHASE: I

NCT ID: NCT06430541

Psilocybin and Psychotherapy to Support Fear of Recurrence for Women with Stage I-II Breast Cancer

Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence in Patients Diagnosed With Early-stage Breast Cancer and Ovarian Cancer in Remission Scientific Title

Purpose

To study whether psilocybin and psychotherapy can reduce the fear of recurrence (cancer coming back).

Who is this for?

Women with stage I or stage II breast cancer who completed treatment at least 6 months ago. You must have a support person who agrees to take you home after receiving psilocybin. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Psilocybin, 1 time</li> <li class="seamTextUnorderedListItem">Psychotherapy, 4 times</li> <li class="seamTextUnorderedListItem">Surveys, 5 times within 6 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Psilocybin is a molecule found in psychedelic (magic) mushrooms.</li> <li class="seamTextUnorderedListItem">Psilocybin plus psychotherapy may reduce distress in people with cancer.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling other people with breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06430541' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://nyulangone.org/news/mental-health-benefits-one-dose-psychedelic-drug-last-years-people-cancer' target='_blank'>New York University Langone Health: Psilocybin and Mental Health in People with Cancer</a> </li></ul>

NEAREST SITE: 1455 miles
Sanford Health Worthington
Worthington,MN

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05889988

Studying Nerve Pain from T-DM1 in People with Stage I-IV HER2 Positive Breast Cancer

A Study of the Natural History of Ado-trastuzumab Emtansine (T-DM1)-Induced Peripheral Neuropathy in HER2-positive Breast Cancer Patients Scientific Title

Purpose

To study how trastuzumab emtansine (T-DM1, Kadcyla®) causes nerve pain in people with and without previous nerve pain.

Who is this for?

People with stage I, stage II, stage III, or stage IV (metastatic) HER2 positive (HER2+) breast cancer who are planning to receive treatment with trastuzumab emtansine (T-DM1, Kadcyla®). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neuropathy is nerve pain in your hands and feet as a side effect of cancer treatment. Neuropathy is pain from nerve damage.</li> <li class="seamTextUnorderedListItem">Trastuzumab emtansine (T-DM1, Kadcyla®) is an antibody drug conjugate (ADC).</li> <li class="seamTextUnorderedListItem">An ADC is a type of therapy that combines an antibody that targets cancer cells with a therapy that can kill cancer cells. Because the antibody only targets cancer cells, the ADC does not kill normal cells, making it less likely to cause side effects.</li> <li class="seamTextUnorderedListItem">T-DM1's antibody targets HER2, a protein that is expressed by some breast cancer cells, and it delivers an anti-cancer drug called emtansine.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05889988' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted-therapy/kadcyla' target='_blank'>Breastcancer.org: Trastuzumab Emtansine (T-DM1, Kadcyla®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/neuropathy' target='_blank'>Breastcancer.org: Nerve Pain</a> </li></ul>

NEAREST SITE: 1455 miles
Sanford Worthington Medical Center
Worthington,MN

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT06028022

Reishi Mushroom Extract for Fatigue and Pain for People with Stage 0-III Breast Cancer

Reishi Mushroom Extract for Fatigue and/or Arthralgias in Patients With Breast Cancer on Aromatase Inhibitors: A Randomized Phase II MNCCTN Trial Scientific Title

Purpose

To study the ability of Reishi mushroom extract to reduce fatigue, joint pain, and/or muscle pain.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III estrogen receptor positive (ER+) breast cancer who are receiving an aromatase inhibitor and experiencing fatigue. You must not be receiving a CDK4/6 inhibitor or olaparib (Lynparza®). Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Reishi mushroom extract, by mouth, daily for the first month</li> <li class="seamTextUnorderedListItem">Placebo for Reishi mushroom extract, by mouth, daily for the second month</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for Reishi mushroom extract, by mouth, daily for the first month</li> <li class="seamTextUnorderedListItem">Reishi mushroom extract, by mouth, daily for the second month</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aromatase inhibitors are a type of hormone therapy commonly used to treat hormone receptor-positive breast cancer. The approved aromatase inhibitors are anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®).</li> <li class="seamTextUnorderedListItem">Side effects of aromatase inhibitors may include fatigue, joint pain, and/or muscle pain.</li> <li class="seamTextUnorderedListItem">Studies suggest that Reishi mushroom extract has beneficial effects including reducing fatigue.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06028022' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/aromatase-inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors and Pain</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancercare.org/questions/11' target='_blank'>Cancer Care: Aromatase Inhibitors and Fatigue</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healthline.com/nutrition/reishi-mushroom-benefits#TOC_TITLE_HDR_8' target='_blank'>Healthline: Reishi Mushroom Extract</a> </li></ul>

NEAREST SITE: 1539 miles
Mayo Clinic Health System in Mankato
Mankato,MN

VISITS: 2 visits

PHASE: NA

NCT ID: NCT05417867

Gut Microbiome and Chemotherapy-Induced Nausea in Women with Stage I-III Breast Cancer

A Pilot Study of the Associations Between Chemotherapy-Induced Nausea in Breast Cancer Patients and Gut Microbiome Composition Profiles Scientific Title

Purpose

To study how changes in bacteria in the gut (microbiome) may be associated with chemotherapy-induced nausea.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy. You must be receiving care at Mayo Clinic Arizona or Mayo Clinic Florida. Full eligibility criteria

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You will complete the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Provide stool samples, 2 times</li> <li class="seamTextUnorderedListItem">Complete questionnaires, 2 times</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The microbiome consists of the many bacteria, viruses, and fungi found in the digestive tract. Most of the microbiome consists of bacteria in your digestive system. These bacteria can be beneficial or harmful. The harmful bacteria cause disease, and the beneficial bacteria help keep you healthy.</li> <li class="seamTextUnorderedListItem">Nausea is a common side effect of many types of chemotherapy.</li> <li class="seamTextUnorderedListItem">You will provide stool samples 2 times: 1) When you begin the trial, and 2) 3-5 days after starting chemotherapy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05417867' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hsph.harvard.edu/nutritionsource/microbiome/' target='_blank'>Harvard University: What is the Microbiome?</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/about-us/news-personal-stories/can-gut-bacteria-help-treat-breast-cancer' target='_blank'>Breast Cancer Now: Gut Bacteria and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/nausea' target='_blank'>Breastcancer.org: Nausea</a> </li></ul>

NEAREST SITE: 1584 miles
University of Minnesota
Minneapolis,MN

VISITS: 5 visits in 1 year

PHASE: NA

NCT ID: NCT06580743

Studying Devices to Measure Lymphedema After Surgery

Efficacy Verification in Early Diagnosis and Management of Lymphedema Through Home Body Water Analyzer Scientific Title

Purpose

To study devices that measure lymphedema (swelling in the arms).

Who is this for?

People with stage 0 (DICS), stage I, stage II, or stage III breast cancer or people at high risk for breast cancer who are planning to receive or have received (within the past year) surgery, axillary lymph node dissection (ALND), and/or sentinel lymph node biopsy (SLNB). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Arm measurements, at home, daily for 1 year</li> <li class="seamTextUnorderedListItem">Arm measurements, at visits, 5 times in 1 year</li> <li class="seamTextUnorderedListItem">Interview</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">One in five women who have been treated for breast cancer develop lymphedema, usually in the arms. </li> <li class="seamTextUnorderedListItem">Lymphedema is the build-up of fluid in tissues, which results in tissue swelling that can affect range of motion and function of the arm. </li> <li class="seamTextUnorderedListItem">This study is studying a device that measures arm swelling in the clinic and a device that measures arm swelling at home.</li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND).</li> <li class="seamTextUnorderedListItem">A sentinel lymph node biopsy (SLNB) is used to see if breast cancer cells are found in the sentinel node, the first lymph node under the arm to which the cancer cells are most likely to have spread.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06580743' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN

VISITS: At least 2 times within 1 year

PHASE: NA

NCT ID: NCT06557057

Studying Blood Sugar During Hormone Therapy for Postmenopausal Women with Stage 0-IV HR+ Breast Cancer

Impact of Aromatase Inhibitor Therapy on Glucose Homeostasis and Diabetes Risk Scientific Title

Purpose

To study the effect of hormone therapy on blood sugar.

Who is this for?

Postmenopausal women with stage 0 (DCIS), stage I, stage II, stage III, or stage IV (metastatic) hormone receptor positive (ER+ and/or PR+) breast cancer who are receiving (within 6 months of starting) or planning to receive an aromatase inhibitor or tamoxifen (Nolvadex®), as well as postmenopausal women without breast cancer. You must not have diabetes. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood sugar tests, 2 times within 1 year</li> <li class="seamTextUnorderedListItem">Body composition scan</li> <li class="seamTextUnorderedListItem">Phone calls, 2 times in 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Results from people with breast cancer will be compared to people without breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06557057' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03879629

Carvedilol to Prevent or Treat Treatment Related Heart Problems for HER2+ Breast Cancer

TrAstuzumab Cardiomyopathy Therapeutic Intervention With Carvedilol (TACTIC) Trial Scientific Title

Purpose

To study if carvedilol (Coreg®), a beta-blocker medication, can prevent or treat heart problems caused by cancer treatments.

Who is this for?

People with stage I, stage II, or stage III HER2 positive (HER2+) breast cancer who are planning to receive treatment with trastuzumab (Herceptin®) or T-DM1 (Kadcyla®). Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1: Begin Before Targeted Therapy <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carvedilol (Coreg®), by mouth, daily, until end of anti-HER2 targeted therapy</li> </ul> Group 2: Begin After Early Signs of Heart Problems <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carvedilol (Coreg®), by mouth, daily, until end of anti-HER2 targeted therapy</li> </ul> Group 3: Begin After Heart Problems Begin (Standard of Care) <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carvedilol (Coreg®), by mouth, daily, until end of anti-HER2 targeted therapy</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">After end of anti-HER2 targeted therapy, you will randomly either continue carvedilol (Coreg®) for 1 year or stop carvedilol (Coreg®)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast cancer treatments can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">Carvedilol (Coreg®) is a type of medication called a beta-blocker. It is approved to treat people who have high blood pressure or heart failure or who have had a heart attack.</li> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®) or T-DM1 (Kadcyla®) are anti-HER2 targeted therapies known to increase the risk of heart problems.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03879629' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/drugs-supplements/carvedilol-oral-route/description/drg-20067565' target='_blank'>Mayo Clinic: Carvedilol (Coreg®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20111208b' target='_blank'>Breastcancer.org: Heart Problems Caused by Herceptin May Be More Common Than Thought</a> </li></ul>

NEAREST SITE: 1623 miles
University of Missouri
Columbia,MO

VISITS: Up to 1 visit every week for 3 months

PHASE: NA

NCT ID: NCT06545045

Training to Improve Thinking Ability After Treatment for Women with Stage I-III Breast Cancer

Pilot Testing of Metacognitive Strategy Training to Address Cancer-related Cognitive Impairment in Breast Cancer Scientific Title

Purpose

To study if training can improve cognition (ability to think) and quality of life.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who completed treatment between 6 months and 3 years ago and are having cognitive (thinking) problems. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Training to improve cognition, in person, weekly for 2.5 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times in 3 months</li> <li class="seamTextUnorderedListItem">Cognitive tests, 2 times in 3 months</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Phone call, weekly for 3 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times in 3 months</li> <li class="seamTextUnorderedListItem">Cognitive tests, 2 times in 3 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Most breast cancer survivors have problems with cognition (thinking), which includes planning, problem-solving, multitasking, memory, and processing speed after cancer treatment.</li> <li class="seamTextUnorderedListItem">In this trial, the training includes identifying 5 goals, creating a plan to achieve each goal, carrying out the plan, and checking to see if the plan worked.</li> <li class="seamTextUnorderedListItem">Training sessions are 45 minutes each and are led by a trained occupational therapist.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06545045' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05056857

Studying the Effects of Tamoxifen in People with ER+ Breast Cancer

Neutrophil Functions in Breast Cancer Scientific Title

Purpose

To study the long-term effects of tamoxifen (Nolvadex®) on excessive production of neutrophil extracellular traps (NET) and their impact on breast cancer and side effects.

Who is this for?

Pre-menopausal and post-menopausal women with stage I, stage II, stage III, or stage IV (metastatic) estrogen receptor positive (ER+) breast cancer receiving treatment with tamoxifen for at least 6 months. Full eligibility criteria

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You will provide the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood samples</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neutrophil extracellular traps (NET) are produced by the body to fight infections but have also been linked to side effects caused by the body's immune system.</li> <li class="seamTextUnorderedListItem">Treatment with tamoxifen (Nolvadex®) increases the production of NETs.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05056857' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/drugs/9785-tamoxifen' target='_blank'>Cleveland Clinic: Tamoxifen (Nolvadex®)</a> </li></ul>

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05928325

Education and Support Program to Improve the Health of Older Adults with Stage I-III Breast Cancer

Implementation of a Geriatric Care Survivorship Intervention in Older Adults Who Have Completed Curative Intent Therapy for Early-Stage Breast Cancer Scientific Title

Purpose

To study the ability of an education and support survivorship program to improve the overall health of older adults who have completed breast cancer treatment.

Who is this for?

People at least 65 years old with stage I, stage II, or stage III breast cancer who are within 3 months of completing chemotherapy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health assessments, 3 times within 1 year</li> <li class="seamTextUnorderedListItem">Education about survivorship</li> <li class="seamTextUnorderedListItem">Wearable device, 1 year</li> <li class="seamTextUnorderedListItem">Supportive therapy</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The health assessment asks about your physical, mental, and emotional health.</li> <li class="seamTextUnorderedListItem">Wearable devices such as FitBits are used to track your physical activity.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05928325' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.bcrf.org/blog/breast-cancer-elderly-treating-growing-patient-population/?psafe_param=1&utm_source=google&utm_medium=cpc&gclid=Cj0KCQjwuZGnBhD1ARIsACxbAVgxOj7KCm21Zmg5TCplhMCDhvola-e-h9IoQWD0A-pi9eLpEHWIIfgaAsz1EALw_wcB' target='_blank'>Breast Cancer Research Foundation: Older Adults and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mycarg.org/?page_id=437' target='_blank'>Cancer and Aging Resource Group: Improving the Care of Older Adults with Cancer</a> </li></ul>

NEAREST SITE: 1643 miles
Baylor St. Luke's Medical Center
Houston,TX

VISITS: 2 visits in 6 months

PHASE: I-II

NCT ID: NCT05269160

Dermaprazole Cream for Radiation Dermatitis in People with Stage I-III Breast Cancer

A Phase I/II Study of Dermaprazole For Radiation Dermatitis in Post-Mastectomy Breast Cancer and Head and Neck Cancer Patients.(TOPAZ) Scientific Title

Purpose

To study the safety, best dose, and ability of esomeprazole cream (Dermaprazole) to treat radiation dermatitis.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who are planning to receive radiation after surgery (adjuvant). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Esomeprazole cream (Dermaprazole) on the breast skin, daily during radiation</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation dermatitis involves redness, dryness, and/or peeling of the skin.</li> <li class="seamTextUnorderedListItem">There is currently no standard therapy for radiation dermatitis.</li> <li class="seamTextUnorderedListItem">Esomeprazole cream, which is often called Dermaprazole, may decrease skin inflammation and irritation.</li> <li class="seamTextUnorderedListItem">You will be instructed to use the cream for 2 weeks before radiation, during radiation, and 2 weeks after radiation.</li> <li class="seamTextUnorderedListItem">This trial is enrolling people with lobular breast cancer and other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05269160' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/esomeprazole-topical-cream' target='_blank'>National Cancer Institute: Esomeprazole Topical Cream</a> </li></ul>

NEAREST SITE: 1683 miles
The University of Texas Medical Branch, Galveston
Galveston,TX

VISITS: 2 visits in 3 months

PHASE: NA

NCT ID: NCT06395506

Exercise and Creatine Supplement to Increase Strength of Women After Chemotherapy

An Open-label Randomized Trial of Exercise ± Creatine Supplementation to Augment the Adaptations of Exercise Training in Cancer Survivors (THRIVE) Scientific Title

Purpose

To study if creatine supplements can help people with breast cancer respond more quickly to exercise and improve strength.

Who is this for?

Women with stage I, stage II, and stage III breast cancer who have completed chemotherapy in the last 6 months, and women who have not been diagnosed with breast cancer. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Creatine and Exercise <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Creatine, by mouth, daily for 3 months</li> <li class="seamTextUnorderedListItem">Exercise sessions, virtual, 3 times every week for 3 months</li> <li class="seamTextUnorderedListItem">Wear a Fitbit</li> <li class="seamTextUnorderedListItem">Strength and walking tests, 2 times in 3 months</li> <li class="seamTextUnorderedListItem">DEXA scan, 2 times in 3 months</li> <li class="seamTextUnorderedListItem">MRI scan, 2 times in 3 months</li> </ul> Group 2: Exercise Only <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise sessions, virtual, 3 times every week for 3 months</li> <li class="seamTextUnorderedListItem">Wear a Fitbit</li> <li class="seamTextUnorderedListItem">Strength and walking tests, 2 times in 3 months</li> <li class="seamTextUnorderedListItem">DEXA scan, 2 times in 3 months</li> <li class="seamTextUnorderedListItem">MRI scan, 2 times in 3 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is comparing information from women who have never had breast cancer to women who have completed chemotherapy for breast cancer.</li> <li class="seamTextUnorderedListItem">Creatine is a supplement that may help you improve strength and physical function.</li> <li class="seamTextUnorderedListItem">A Fitbit is device you wear on your wrist that tracks your physical activity.</li> <li class="seamTextUnorderedListItem">DEXA scans use x-ray energy to measure bone density (thickness and strength of bones).</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06395506' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1832 miles
Medical College of Wisconsin
Milwaukee,WI

VISITS: 3 visits in 1 year

PHASE: NA

NCT ID: NCT03824145

Every Day Counts Lifestyle Program to Improve Quality of Life for Women with Metastatic Breast Cancer

Every Day Counts: A Lifestyle Program for Women With Metastatic Breast Cancer Scientific Title

Purpose

To study whether the Every Day Counts lifestyle program improves the quality of life of women with metastatic breast cancer.

Who is this for?

Women with metastatic (stage IV) breast cancer that is currently stable and who live in Milwaukee, Wisconsin or Chicago, Illinois. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Every Day Counts lifestyle program, 4 months</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Home/work organization intervention, 4 months</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Every Day Counts lifestyle program</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Every Day Counts lifestyle program promotes nutritional and physical activity changes based on the American Cancer Society nutrition and physical activity guidelines.</li> <li class="seamTextUnorderedListItem">The Every Day Counts lifestyle program consists of: 1) a curriculum binder covering weekly topics and including self-monitoring tools to support adherence; 2) lifestyle coaching for 16-weeks, with in-person or virtual supervised exercise sessions and telephone-based sessions; 3) exercise supplies (Fitbit, resistance bands), 4) twice weekly text messaging targeting self-efficacy and social support; and 5) attendance to cooking classes emphasizing plant-based eating.</li> <li class="seamTextUnorderedListItem">The home/work organization intervention consists of: 1) a book with overview of home/work organization program with 16 weekly topics with an overview of each chapter, 2) virtual or weekly phone calls with a home organization coach with standard prompts, 3) text messages supporting home/work organization.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03824145' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://redcap.mcw.edu/surveys/?s=84MA4DRTTTA8FRCD' target='_blank'>Medical College of Wisconsin: Trial Information Brochure</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/healthy/eat-healthy-get-active/acs-guidelines-nutrition-physical-activity-cancer-prevention/guidelines.html' target='_blank'>American Cancer Society: Guideline for Diet and Physical Activity</a> </li></ul>

NEAREST SITE: 1832 miles
Froedtert Hospital & the Medical College of Wisconsin
Milwaukee,WI

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT06106477

Intermittent Fasting to Improve Quality of Life for People with Stage I-III ER+, HER2- Breast Cancer

Impact of Intermittent Fasting on Biomarkers of Inflammation and Health-Related Quality of Life: A Feasibility Trial for Women With HR+/HER2- Early Breast Cancer Scientific Title

Purpose

To study if intermittent fasting improves health-related quality of life.

Who is this for?

People with stage I, stage II, or stage III estrogen receptor positive (ER+ or ER low), HER2 negative (HER2- or HER2 low) breast cancer who are planning to receive hormone therapy after surgery (adjuvant). You must have a body mass index (BMI) of at least 25. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intermittent fasting, daily, 6 months</li> <li class="seamTextUnorderedListItem">Surveys</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">In this trial, intermittent fasting (not eating) means that you are allowed to eat during a 10 hour period, with the last meal of the day between 5:00 PM and 9:00 PM.</li> <li class="seamTextUnorderedListItem">In this trial, HER2 low is defined as IHC 1+ or IHC 2+/FISH-.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06106477' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1832 miles
Medical College of Wisconsin
Wauwatosa,WI

VISITS: At least 3 visits in 1 year

PHASE: NA

NCT ID: NCT05223322

Exercise to Reduce Side Effects During Treatment for Women with Stage I-III Breast Cancer

DECODE Heartland: Understanding and Addressing Disparities in Cancer Therapy Induced Inflammation and Associated Endothelial Dysfunction Scientific Title

Purpose

To study if exercise improves side effects caused by chemotherapy and anti-HER2 targeted therapy.

Who is this for?

Black/African American or non-Hispanic White women with stage I, stage II, or stage III breast cancer who are receiving chemotherapy with doxorubicin (Doxil®) or anti-HER2 targeted therapy with trastuzumab (Herceptin®), pertuzumab (Perjeta®), tucatinib (Tukysa®), neratinib (Nerlynx®), margetuximab (Margenza®), trastuzumab deruxtecan (Enhertu®, T-DXd), and/or trastuzumab emtansine (Kadcyla®, T-DM1). Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise program, up to 2.5 hours every week for 4-5 months</li> <li class="seamTextUnorderedListItem">Exercise information, resistance bands, and activity tracker</li> <li class="seamTextUnorderedListItem">Physical tests, 3 times in 1 year</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times in 1 year</li> <li class="seamTextUnorderedListItem">Ultrasound, 3 times in 1 year</li> <li class="seamTextUnorderedListItem">Blood tests and biopsies, 3 times in 1 year</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Supportive text messages, weekly</li> <li class="seamTextUnorderedListItem">Physical tests, 3 times in 1 year</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times in 1 year</li> <li class="seamTextUnorderedListItem">Ultrasound, 3 times in 1 year</li> <li class="seamTextUnorderedListItem">Blood tests and biopsies, 3 times in 1 year</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise information, resistance bands, and activity tracker (optional)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some cancer medications such as chemotherapy and anti-HER2 targeted therapy may harm blood vessels.</li> <li class="seamTextUnorderedListItem">Harm to blood vessels may negatively affect physical health.</li> <li class="seamTextUnorderedListItem">Exercise may improve these negative effects.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05223322' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1835 miles
Carle Health
Urbana,IL

VISITS: Coincides with routine care

PHASE: NA

NCT ID: NCT05484973

AMMA Portable Scalp Cooling to Prevent Hair Loss During Chemotherapy for Women with Stage I-III Breast Cancer

A Post-market Multi-center Prospective Study to Assess the Ability of the Portable Scalp Cooling System (PSCS) to Prevent Hair Loss in Women Receiving Specific Chemotherapy Regimens for Breast Cancer Stages I-III. Scientific Title

Purpose

To study the ability of the AMMA portable scalp cooling system to prevent hair loss in women receiving chemotherapy.

Who is this for?

Women at least 21 years old with stage I, stage II, or stage III breast cancer who are planning to receive or receiving paclitaxel (Taxol®), nab-paclitaxel (Abraxane®), or docetaxel (Taxotere®) chemotherapy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AMMA portable scalp cooling device during chemotherapy sessions</li> <li class="seamTextUnorderedListItem">Surveys</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will wear the AMMA scalp cooling device 30 minutes before, during, and for at least 2.5 hours after each chemotherapy session.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05484973' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1853 miles
University of Illinois Chicago
Chicago,IL

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05259410

Time Restricted Eating During Chemotherapy for Women with Stage I-III Breast Cancer

The Safety and Efficacy of Time Restricted Eating Combined With Chemotherapy During Breast Cancer Treatment Scientific Title

Purpose

To study whether time restricted eating during chemotherapy improves treatment-related outcomes and quality of life and limits treatment-related side effects and weight gain.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy after surgery. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Time restricted eating, 3 months</li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No time restricted eating, 3 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Time restricted eating, a form of intermittent fasting, is eating all food within the hours of 10:00am and 6:00pm, with water fasting the remaining hours of the day.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05259410' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/intermittent-fasting-may-help-cancer-treatments-work-better' target='_blank'>Breastcancer.org: Intermittent Fasting May Help Cancer Treatments Work Better</a> </li></ul>

NEAREST SITE: 1856 miles
Northwestern University
Chicago,IL

VISITS: 3 visits within 1 year

PHASE: NA

NCT ID: NCT06081127

Physical Therapy and Education Before Treatment for Women with Stage 0-IV Breast Cancer

A Randomized Pilot Test of the Breast Cancer Pre-habilitation and Prospective Surveillance to Prevent, Detect, and Optimize Physical and Functional Recovery (MOve-ABC) (B-PREPed) Scientific Title

Purpose

To study the ability of the Moving On After Breast Cancer (MOve-ABC) program to provide physical therapy and education before breast cancer treatment.

Who is this for?

Women with newly diagnosed stage 0 (DCIS), stage I, stage II, stage III, or stage IV (metastatic) breast cancer who have not yet received treatment. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Moving On After Breast Cancer (MOve-ABC) Program <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education about breast cancer side effects</li> <li class="seamTextUnorderedListItem">Physical therapy evaluation</li> <li class="seamTextUnorderedListItem">Home exercise program</li> <li class="seamTextUnorderedListItem">Phone calls and text messages</li> <li class="seamTextUnorderedListItem">Additional referrals (if needed)</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education on surgery recovery and pain management</li> <li class="seamTextUnorderedListItem">Additional referrals (if needed)</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Physical therapy before cancer treatment aims to help with early identification and self-management of treatment side effects.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06081127' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/exercise' target='_blank'>Breastcancer.org: Exercise and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cedars-sinai.org/health-library/diseases-and-conditions/p/physical-therapy---breast-cancer.html' target='_blank'>Cedars Sinai: Physical Therapy for Breast Cancer</a> </li></ul>

NEAREST SITE: 1946 miles
Indiana University
Indianapolis,IN

VISITS: 3 visits within 6 months

PHASE: NA

NCT ID: NCT04586530

Memory and Attention Training to Improve Cognition After Chemotherapy for Stage I-III Breast Cancer

Mobile Device CBT for Chemotherapy-Related Cognitive Dysfunction: A Multi-Center Randomized Controlled Trial (TAMS) Scientific Title

Purpose

To determine if Memory and Attention Adaptation Training (MAAT) improves cognition (the ability to think).

Who is this for?

People with stage I, stage II, or stage III breast cancer who completed chemotherapy 1-5 years ago and have cognition (thinking and memory) problems. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Memory and Attention Adaptation Training (MAAT), virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires and memory tests, 3 times in 6 months</li> <li class="seamTextUnorderedListItem">Functional MRI scan, 2 times in 2 months (optional) </li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General support sessions, virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires and memory tests, 3 times in 6 months</li> <li class="seamTextUnorderedListItem">Functional MRI scan, 2 times in 2 months (optional)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Difficulty thinking, known as cognitive dysfunction or chemo brain, is common after chemotherapy.</li> <li class="seamTextUnorderedListItem">Memory and Attention Adaptation Training (MAAT) is a cognitive behavioral therapy (CBT) tool that increases self-awareness of situations in which memory problems occur, regulates emotion about memory problems, and helps people find strategies to improve daily memory tasks.</li> <li class="seamTextUnorderedListItem">This trial will use an advanced brain MRI technique called functional MRI (fMRI).</li> <li class="seamTextUnorderedListItem">fMRI measures changes in blood flow that happen during mental activity.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04586530' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 1959 miles
Center for Cognitive Medicine at Vanderbilt University
Nashville,TN

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05283629

Improving Chemotherapy-Related Cognitive Problems After Treatment in People with Stage I-III Breast Cancer

Neuroplasticity-Based Cognitive Remediation for Chemotherapy Related Cognitive Impairment Randomized Study Scientific Title

Purpose

To study the ability of a type of training called neuroplasticity-based computerized cognitive remediation (nCCR) to treat chemotherapy-related cognitive impairment (CRCI).

Who is this for?

People between 35-80 years of age who have been diagnosed with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who have completed treatment. You must have cognitive problems as a result of receiving chemotherapy within the last 1-8 years. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neuroplasticity-based Computerized Cognitive Remediation (nCCR)</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Educational DVDs</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neuroplasticity-based Computerized Cognitive Remediation (nCCR) aims to improve processing of sensory stimuli and cognitive control functions.</li> <li class="seamTextUnorderedListItem">Educational DVDs include content on history, art, science, etc. and are comparable to nCCR in length, audio-visual presentation, computer use, and contact with research staff.</li> <li class="seamTextUnorderedListItem">Chemotherapy-related cognitive impairment (CRCI), often referred to as <q>chemo brain</q>, is a common and highly distressful side effect of chemotherapy.</li> <li class="seamTextUnorderedListItem">The most commonly reported CRCI symptoms include problems with executive function, which is involved in planning, problem-solving, organization, and time management.</li> <li class="seamTextUnorderedListItem">The term <q>neuroplasticity</q> refers to the brain's ability to modify, change, and adapt throughout life and in response to experience. Neuroplasticity can be improved through the use of focused brain training in nCCR.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05283629' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/podcast/chemobrain-update' target='_blank'>Breastcancer.org: Chemo Brain Update: Cancer-Related Cognitive Decline</a> </li></ul>

NEAREST SITE: 2013 miles
University of Alabama at Birmingham
Birmingham,AL

VISITS: 3 visits per week for 2.5 months

PHASE: NA

NCT ID: NCT04088708

Impact of Exercise on Gut Microbiome and Fatigue After Treatment

Role of Gut Microbe Composition in Psychosocial Symptom Response to Exercise Training in Breast Cancer Survivors (ROME Study) Scientific Title

Purpose

To study if exercise changes the gut microbiome and fatigue levels.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who have completed treatment at least 1 year ago and are experiencing fatigue. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aerobic exercise sessions with an instructor, 20-60 minutes, 3 times a week, 10 weeks</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Flexibility/toning exercise sessions with an instructor, 40 minutes, 3 times a week, 10 weeks</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires, 4 times</li> <li class="seamTextUnorderedListItem">Wearable device</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cancer survivors are at increased risk of gut bacteria communities (microbiome) that can negatively impact health and energy levels.</li> <li class="seamTextUnorderedListItem">Exercise may cause healthy changes in the gut microbiome.</li> <li class="seamTextUnorderedListItem">Fatigue (severe tiredness) is a common long-term side effect of breast cancer treatment.</li> <li class="seamTextUnorderedListItem">Aerobic exercise refers to cardiovascular exercise, which includes activities such as walking, running, biking, and swimming.</li> <li class="seamTextUnorderedListItem">Flexibility/toning activities will target the head/neck, shoulder, elbow/forearm, hand/wrist, trunk/hip, and ankle/foot.</li> <li class="seamTextUnorderedListItem">Wearable devices are used to track your physical activity outside of exercise sessions.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04088708' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.dana-farber.org/for-patients-and-families/for-survivors/caring-for-yourself-after-cancer/your-body-after-treatment/' target='_blank'>Dana-Farber Cancer Institute: Your Body After Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e22178' target='_blank'>ASCO Abstract: Gut Microbiome Alterations in Breast Cancer Survivors with Cancer-Related Fatigue</a> </li></ul>

NEAREST SITE: 2054 miles
University of Michigan
Ann Arbor,MI

VISITS: 1 visit

PHASE: NA

NCT ID: NCT06679400

Massage for Shoulder or Chest Pain for Women After Breast Cancer Treatment

Effects of Myofascial Massage and Patient-therapist Communication Levels on Shoulder Muscle Properties in Breast Cancer Survivors with Myofascial Pain Scientific Title

Purpose

To study if shoulder muscle massage can relieve shoulder muscle pain and how changes may be related to the amount of communication with the massage therapist.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who have completed treatment (except for long-term treatment taken by mouth) between 3 months and 2 years ago. You must have muscle pain in the upper part of your chest. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Shoulder and chest massage, 1 time</li> <li class="seamTextUnorderedListItem">More communication with the massage therapist</li> <li class="seamTextUnorderedListItem">Ultrasound scan, 2 times</li> <li class="seamTextUnorderedListItem">Surveys, 2 times</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Shoulder and chest massage, 1 time</li> <li class="seamTextUnorderedListItem">Less communication with the massage therapist</li> <li class="seamTextUnorderedListItem">Ultrasound scan, 2 times</li> <li class="seamTextUnorderedListItem">Surveys, 2 times</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Myofascial pain is muscle pain.</li> <li class="seamTextUnorderedListItem">Ultrasounds use sound waves to produce images of structures within your body without using radiation.</li> <li class="seamTextUnorderedListItem">The ultrasound scans will help see muscle changes before and after massage.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06679400' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2054 miles
University of Michigan Rogel Cancer Center
Ann Arbor,MI

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT06617455

Fezolinetant to Reduce Hot Flashes and Night Sweats for Women Receiving Hormone Therapy

Phase 2 Randomized, Cross-over Trial of Fezolinetant for Treatment of Vasomotor Symptoms in Patients Taking Endocrine Therapy (VEnT) Scientific Title

Purpose

To study if fezolinetant can reduce hot flashes and night sweats for women receiving hormone therapy.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer or women at high risk of breast cancer who are receiving or planning to receive tamoxifen (Nolvadex®), letrozole (Femara®), anastrozole (Arimidex®), or exemestane (Aromasin®) hormone therapy. You must be experiencing hot flashes and/or night sweats. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Fezolinetant First <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fezolinetant, by mouth, daily for 1 month</li> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> followed 2 weeks later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for fezolinetant, by mouth, daily for 1 month</li> </ul> Group 2: Placebo First <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for fezolinetant, by mouth, daily for 1 month</li> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> followed 2 weeks later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fezolinetant, by mouth, daily for 1 month</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy is effective for lowering the risk of breast cancer and preventing breast cancer recurrence but can cause bothersome side effects including hot flashes and night sweats, called vasomotor symptoms.</li> <li class="seamTextUnorderedListItem">Fezolinetant is used to manage these symptoms in postmenopausal women and may also work in people with breast cancer who are receiving hormone therapy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06617455' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2107 miles
Stephanie Spielman Comprehensive Breast Center
Columbus,OH

VISITS: 2 visits every week for 2 months

PHASE: NA

NCT ID: NCT05114005

Tango Dance Classes to Improve Nerve Pain After Chemotherapy for Stage I-III Breast Cancer

Novel Interventions for Chemotherapy-Induced Neuropathy Scientific Title

Purpose

To study whether Tango dance classes can improve nerve pain, posture, balance, and quality of life.

Who is this for?

People at least 40 years old with stage I, stage II, or stage III breast cancer who have completed chemotherapy at least 3 months ago. You must be experiencing nerve pain and posture issues. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tango dance classes, 2 times every week for 2 months</li> <li class="seamTextUnorderedListItem">Assessment of balance and posture</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Home exercise, 2 times every week for 2 months</li> <li class="seamTextUnorderedListItem">Education about how to prevent falls and nerve pain</li> <li class="seamTextUnorderedListItem">Assessment of balance and posture</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Neuropathy is nerve pain in your hands and feet as a side effect of cancer treatment such as chemotherapy.</li> <li class="seamTextUnorderedListItem">Group dance classes can improve physical health.</li> <li class="seamTextUnorderedListItem">Because group dance classes are a social activity, they may also improve quality of life.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05114005' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.everydayhealth.com/fitness-pictures/health-benefits-of-dance.aspx' target='_blank'>Everyday Health: The Benefits of Dancing</a> </li></ul>

NEAREST SITE: 2108 miles
Ohio State University Comprehensive Cancer Center
Columbus,OH

VISITS: 8 visits within 9 months

PHASE: NA

NCT ID: NCT05984888

MIND Diet and Nutrition Counseling to Improve Brain Function for People with Stage II-IV HR+ Breast Cancer

Protecting the Brain From Toxic Side Effects of Chemotherapy: a Pilot Study of a MIND Diet Intervention in Women Undergoing Active Treatment for Breast Cancer Scientific Title

Purpose

To study the impact of the Neurodegenerative Delay (MIND) diet on your cognition (ability to think).

Who is this for?

Postmenopausal women 45 to 75 years old with stage II, stage III, or stage IV (metastatic) hormone receptor positive (ER+ and/or PR+) breast cancer who are planning to begin treatment within 1 month. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nutrition counseling about the MIND diet, 8 in-person sessions within 3 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General health (non-diet) counseling, 8 in-person sessions within 3 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cancer treatment can lead to cognition (ability to think) problems and low quality of life.</li> <li class="seamTextUnorderedListItem">The Neurodegenerative Delay (MIND) diet is high in anti-inflammatory nutrients (omega-3, carotenoids, B vitamins, etc.) and limits foods that are not healthy for the brain (butter, cheese, red meat, fried foods, sugar, etc.).</li> <li class="seamTextUnorderedListItem">The MIND diet may help improve brain function during cancer treatment.</li> <li class="seamTextUnorderedListItem">Cognition is your ability to think.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05984888' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://health.osu.edu/wellness/exercise-and-nutrition/the-mind-diet' target='_blank'>Ohio State University: The MIND Diet and Brain Health</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/diseases/21032-chemo-brain' target='_blank'>Cleveland Clinic: Chemotherapy and Brain Function Problems</a> </li></ul>

NEAREST SITE: 2108 miles
Ohio State University Comprehensive Cancer Center
Columbus,OH

VISITS: 2 visits in 2.5 months

PHASE: NA

NCT ID: NCT05677802

Stress Management Therapy for Women with Stage I-III Triple Negative Breast Cancer

Examining the Feasibility of Implementing a Biobehavioral Stress Reduction Program in Triple Negative Breast Cancer Patients Scientific Title

Purpose

To study if stress management therapy reduces stress and addresses health-related social needs.

Who is this for?

Women with newly diagnosed stage I, stage II, or stage III triple negative (ER-, PR-, HER2-) breast cancer who have not yet received treatment. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stress management therapy, 10 sessions in 2.5 months</li> <li class="seamTextUnorderedListItem">Blood tests, 2 times in 2.5 months</li> <li class="seamTextUnorderedListItem">Surveys</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The stress management therapy includes progressive muscle relaxation, coping, problem solving, communication, and social support.</li> <li class="seamTextUnorderedListItem">Health related social needs (such as utilities and transportation) will be evaluated at the beginning of the study, and referrals will be made to social work to help address those needs.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05677802' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/living-beyond-breast-cancer/life-after-breast-cancer-treatment/coping-emotionally/managing-stress-anxiety#:~:text=After%20a%20diagnosis%20of%20breast,and%20cope%20better%20with%20anxiety' target='_blank'>Breast Cancer Now: Coping with Stress Following a Breast Cancer Diagnosis</a> </li></ul>

NEAREST SITE: 2136 miles
Grady Health System
Atlanta,GA

VISITS: Up to 1-2 visits every week for 3 months

PHASE: NA

NCT ID: NCT06534125

Acupuncture or Acupressure to Prevent Joint Pain from Hormone Therapy for Postmenopausal Non-Hispanic Black Women with Stage I-III HR+, HER2- Breast Cancer

Preventing Aromatase Inhibitor-Associated Arthralgias Among Non-Hispanic Black Postmenopausal Women with Early-Stage Breast Cancer Scientific Title

Purpose

To compare the ability of in-person acupuncture and at-home acupressure to prevent joint pain from hormone therapy.

Who is this for?

Postmenopausal non-Hispanic Black women with stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who completed treatment at least 2 weeks ago and are planning to receive letrozole (Femara®), anastrozole (Arimidex®), or exemestane (Aromasin®) aromatase inhibitor. You must not have received or be currently receiving palbociclib (Ibrance®), ribociclib (Kisqali®), or abemaciclib (Verzenio®) CDK4/6 inhibitor. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acupuncture, in person, every 1-2 weeks for 3 months</li> <li class="seamTextUnorderedListItem">Surveys</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acupressure, at home, every 1-2 weeks for 3 months</li> <li class="seamTextUnorderedListItem">Surveys</li> </ul> Group 3: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No acupuncture or acupressure</li> <li class="seamTextUnorderedListItem">Surveys</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aromatase inhibitors prolong life in postmenopausal women with HR+ breast cancer.</li> <li class="seamTextUnorderedListItem">However, non-Hispanic Black women are more likely to experience side effects such as joint pain and stop their hormone therapy compared to non-Hispanic white women.</li> <li class="seamTextUnorderedListItem">Acupuncture involves inserting thin needles through the skin at specific points on the body to control pain.</li> <li class="seamTextUnorderedListItem">Acupressure uses the application of pressure or localized massage to specific sites on the body to control symptoms such as pain.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06534125' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2137 miles
Emory University Hospital Midtown
Atlanta,GA

VISITS: 1 visit every day for 2 weeks

PHASE: NA

NCT ID: NCT05368428

Transcutaneous Electrical Nerve Stimulation for Chemotherapy Induced Peripheral Neuropathy in People with Stage I-III Breast Cancer

Single-Institution Trial Investigating the Effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) in Taxane Induced Peripheral Neuropathy (CIPN) in Patients With Early Stage Breast Cancer Scientific Title

Purpose

To determine if transcutaneous electrical nerve stimulation (TENS) reduces chemotherapy induced peripheral neuropathy (CIPN).

Who is this for?

People with stage I, stage II, or stage III breast cancer who are receiving chemotherapy and have chemotherapy induced peripheral neuropathy (CIPN). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Transcutaneous electrical nerve stimulation (TENS), daily for 2 weeks</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy induced peripheral neuropathy (CIPN) is nerve pain in your hands and feet as a side effect of chemotherapy.</li> <li class="seamTextUnorderedListItem">Neuropathy is pain from nerve damage.</li> <li class="seamTextUnorderedListItem">Transcutaneous electrical nerve stimulation (TENS) involves mild electric currents applied to some areas of your skin to potentially improve neuropathy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05368428' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/treatments/15840-transcutaneous-electrical-nerve-stimulation-tens' target='_blank'>Cleveland Clinic: Transcutaneous Electrical Nerve Stimulation (TENS)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/neuropathy' target='_blank'>Breastcancer.org: Neuropathy</a> </li></ul>

NEAREST SITE: 2260 miles
Allegheny General Hospital
Pittsburgh,PA

VISITS: 3 times per week for 3 months

PHASE: NA

NCT ID: NCT06115486

Exercise to Improve Muscle Mass After Treatment for Stage 0-III Breast Cancer

EXERT-BCH: Prospective Study of EXErcise Regimens After Treatment for Breast Cancer to Improve Hypertrophy Scientific Title

Purpose

To compare the ability of 2 group exercise programs to increase muscle mass for women after breast cancer treatment.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who have completed treatment. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Resistance training in a small group, 3 times every week for 3 months</li> <li class="seamTextUnorderedListItem">Strength measurements</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Strength and conditioning training in a small group, 3 times every week for 3 months</li> <li class="seamTextUnorderedListItem">Strength measurements</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise to build muscle mass in people who have been treated for breast cancer may reduce toxicity from treatment, increase time to tumor progression, and prolong survival.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06115486' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2262 miles
University of Pittsburgh
Pittsburgh,PA

VISITS: 2 visits within 2.5 months

PHASE: NA

NCT ID: NCT06879522

Increasing Energy and Reducing Fatigue After Treatment for Women with Stage I-III Breast Cancer

Feasibility and Early Efficacy of the Maximizing Energy Intervention for Decreasing Fatigue Impact in Breast Cancer Survivors (BCS_MAX) Scientific Title

Purpose

To study if the Maximizing Energy program can help manage fatigue.

Who is this for?

Women with stage I, stage II, or some stage III breast cancer who completed treatment at least 6 months ago and are experiencing fatigue. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Maximizing Energy program, virtual, weekly for 1.5 months</li> <li class="seamTextUnorderedListItem">Wear an activity tracker, 2.5 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health education program, virtual, weekly for 1.5 months</li> <li class="seamTextUnorderedListItem">Wear an activity tracker, 2.5 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fatigue is a feeling of tiredness and lack of energy that is not resolved with sleep.</li> <li class="seamTextUnorderedListItem">Fatigue can last even after breast cancer treatments are finished.</li> <li class="seamTextUnorderedListItem">In the Maximizing Energy program, you will track your fatigue, identify fatigue-related problems, and learn how to conserve energy and problem-solve to reduce fatigue. </li> <li class="seamTextUnorderedListItem">The health education program includes education on breast cancer-related fatigue, diet, safe physical activities, and personalized energy conservation strategies.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06879522' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2264 miles
University of Pittsburgh
Pittsburgh,PA

VISITS: At least 5 visits in 8 months

PHASE: NA

NCT ID: NCT06610617

Brain Stimulation to Improve Balance and Cognition After Chemotherapy for Older Women with Stage I-III Breast Cancer

Neuromodulation of Central Sensory Integration to Improve Postural Control: a Pilot Study in Older Women with Breast Cancer Scientific Title

Purpose

To study if brain stimulation can improve balance and cognition (the ability to think).

Who is this for?

Women 65-80 years old with stage I, stage II, or stage III breast cancer who have completed chemotherapy with docetaxel (Taxotere), paclitaxel (Taxol), or nab-paclitaxel (Abraxane®). You must have nerve pain and/or cognition (thinking and memory) problems. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Brain Stimulation First <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Active brain stimulation with device worn on head, 1 time</li> <li class="seamTextUnorderedListItem">Brain and balance tests, 2 times in 8 months</li> </ul> followed 1 week later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Inactive (sham) brain stimulation with device worn on head, 1 time</li> </ul> Group 2: Brain Stimulation Second <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Inactive (sham) brain stimulation with device worn on head, 1 time</li> <li class="seamTextUnorderedListItem">Brain and balance tests, 2 times in 8 months</li> </ul> followed 1 week later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Active brain stimulation with device worn on head, 1 time</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Taxane chemotherapy drugs can cause peripheral neuropathy.</li> <li class="seamTextUnorderedListItem">Peripheral neuropathy is nerve pain in your hands and feet as a side effect of cancer treatment. Neuropathy is pain from nerve damage.</li> <li class="seamTextUnorderedListItem">Neuropathy can lead to cognitive (thinking) problems as well as balance problems and falls.</li> <li class="seamTextUnorderedListItem">Taxane chemotherapy drugs used for breast cancer are docetaxel (Taxotere), paclitaxel (Taxol), and nab-paclitaxel (Abraxane®).</li> <li class="seamTextUnorderedListItem">Each brain stimulation session will be 20 minutes.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06610617' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2273 miles
West Virginia University Cancer Institute
Morgantown,WV

VISITS: At least 2 visits in 2 weeks

PHASE: II

NCT ID: NCT05013255

Pioglitazone to Reduce Fatigue for Women with Stage 0-III HR+, HER2- Breast Cancer

Pioglitazone Therapy Targeting Fatigue in Breast Cancer Scientific Title

Purpose

To study if pioglitazone (Actos®) can reduce fatigue.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who are planning to receive a mastectomy. You must not have received any treatments except chemotherapy, and you must not have diabetes. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Low dose of pioglitazone (Actos®), by mouth, daily for 2 weeks </li> <li class="seamTextUnorderedListItem">Body weight measurements, 2 times in 2 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High dose of pioglitazone (Actos®), by mouth, daily for 2 weeks </li> <li class="seamTextUnorderedListItem">Body weight measurements, 2 times in 2 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times</li> </ul> Group 3: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No drug</li> <li class="seamTextUnorderedListItem">Body weight measurements, 2 times in 2 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires, 2 times</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fatigue is common in people with cancer and is difficult to treat.</li> <li class="seamTextUnorderedListItem">Chemotherapy, radiation, and surgery can make fatigue worse.</li> <li class="seamTextUnorderedListItem">Pioglitazone (Actos®) is an FDA-approved drug that is used to treat insulin resistance in people with diabetes.</li> <li class="seamTextUnorderedListItem">Pioglitazone may improve fatigue.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05013255' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2299 miles
Roswell Park Cancer Institute
Buffalo,NY

VISITS: 1 visit

PHASE: NA

NCT ID: NCT06456411

Brain Scan and Virtual Reality to Decrease Pain for People with Stage 0-IV Breast Cancer

Real-Time Evaluation of Severity of Perceived Pain in Patients With Cancer by Using Functional Near-Infrared Spectroscopy (fNIRS), and Investigation of Pain Relief Utilizing Virtual Reality Technologies Scientific Title

Purpose

To study whether a virtual reality relaxation program can decrease pain and if this can be seen in the brain with a functional near-infrared spectroscopy scan.

Who is this for?

People with stage 0 (DCIS), stage I, stage II, stage III, or stage IV (metastatic) breast cancer who are experiencing pain from treatment, and people who do not have breast cancer. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Virtual Reality and Scan <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Functional near-infrared spectroscopy scan, 1 time</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Virtual reality, 1 time, at least 15 minutes</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Scan Only <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Functional near-infrared spectroscopy scan, 1 time</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Functional near-infrared spectroscopy is a non-invasive type of imaging scan that can show pictures of the brain and brain activity.</li> <li class="seamTextUnorderedListItem">Virtual reality (VR) is a computer-generated experience that simulates the 3D environment.</li> <li class="seamTextUnorderedListItem">Virtual reality relaxation programs may help relieve pain in people with cancer who are receiving treatment. Relief of pain may be seen on a functional near-infrared spectroscopy scan.</li> <li class="seamTextUnorderedListItem">Results from people who do not have breast cancer will be compared to results from people with breast cancer.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06456411' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.techtarget.com/whatis/definition/virtual-reality' target='_blank'>Tech Target: What is Virtual Reality?</a> </li></ul>

NEAREST SITE: 2299 miles
Levine Cancer Institute
Charlotte,NC

VISITS: 1 visit every month for 4-6 months

PHASE: NA

NCT ID: NCT04174742

Questionnaires to Study Pain During Chemotherapy for Women with Stage I-III Breast Cancer

Self-Reported Pain and Nadir White Blood Cell/Absolute Neutrophil Count in Women 45 and Under Compared to Older Women Receiving Pegfilgrastim (or Biosimilar Substitution) While Undergoing Chemotherapy for Non-Metastatic Breast Cancer Scientific Title

Purpose

To study if younger women experience pain during treatment with chemotherapy and pegfilgrastim (Neulasta®) more often and/or at higher levels than older women.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy and pegfilgrastim (Neulasta®). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires about pain</li> <li class="seamTextUnorderedListItem">Blood test, monthly for 4-6 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pegfilgrastim (Neulasta®) is given to help prevent infections in people who are receiving some types of chemotherapy.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04174742' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2314 miles
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem,NC

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03987555

Studying the Amount of Chemotherapy in the Blood in People with Breast Cancer

Pilot Feasibility Study of Paclitaxel Therapeutic Drug Monitoring in Cancer Patients Scientific Title

Purpose

To study the ability of researchers to measure the amount of paclitaxel (Taxol®) in blood and study the effect of paclitaxel (Taxol®) on neuropathy.

Who is this for?

People with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who are planning to receive treatment with paclitaxel (Taxol®) at Wake Forest Comprehensive Cancer Center. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws</li> <li class="seamTextUnorderedListItem">Surveys about neuropathy</li> </ul> Please contact research site for trial schedule
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy drug.</li> <li class="seamTextUnorderedListItem">Neuropathy is pain from nerve damage.</li> <li class="seamTextUnorderedListItem">Nerve damage is one of the most common and severe side effects of paclitaxel (Taxol®).</li> <li class="seamTextUnorderedListItem">The ability to consistently measure paclitaxel (Taxol®) in the blood may allow doctors to control the dose of paclitaxel, so that enough chemotherapy is given to kill the cancer, but the side effect of nerve damage is reduced.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03987555' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/information-support/facing-breast-cancer/going-through-treatment-breast-cancer/chemotherapy/paclitaxel-taxol' target='_blank'>Breast Cancer Now: Paclitaxel (Taxol®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/neuropathy' target='_blank'>Breastcancer.org: Neuropathy</a> </li></ul>

NEAREST SITE: 2314 miles
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem,NC

VISITS: 3 visits within 2 years

PHASE: NA

NCT ID: NCT05309655

Impact of Hormone Therapy on Heart Health in Women with Stage I-III Breast Cancer

The Cardiac Outcomes With Near-Complete Estrogen Deprivation (CROWN) Study Scientific Title

Purpose

To study the effect of near complete estrogen deprivation (NCED) hormone therapy on heart health.

Who is this for?

Premenopausal women 18-55 years old with stage I, stage II, or stage III breast cancer. If you have hormone receptor positive (ER+ and/or PR+) breast cancer, you must be planning to receive or receiving treatment with an aromatase inhibitor or selective estrogen receptor degrader (SERD) hormone therapy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI scans, 3 times</li> <li class="seamTextUnorderedListItem">CT scans, 2 times</li> <li class="seamTextUnorderedListItem">Electrocardiogram (ECG or EKG), 2 times</li> <li class="seamTextUnorderedListItem">Blood tests, 3 times</li> <li class="seamTextUnorderedListItem">Surveys</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Near complete estrogen deprivation (NCED) is treatment with an aromatase inhibitor or selective estrogen receptor degrader (SERD) hormone therapy.</li> <li class="seamTextUnorderedListItem">Some breast cancer treatments can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy.</li> <li class="seamTextUnorderedListItem">A computed tomography (CT) scan produces body pictures created by x-ray energy.</li> <li class="seamTextUnorderedListItem">An electrocardiogram (ECG) test records electrical signals in your heart.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with hormone receptor negative (ER- and/or PR-) breast cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05309655' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.dukehealth.org/clinical-trials/directory/pro00110774' target='_blank'>Duke Health: Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.lbbc.org/about-breast-cancer/side-effects/heart-health' target='_blank'>Living Beyond Breast Cancer: Heart Health</a> </li></ul>

NEAREST SITE: 2314 miles
Wake Forest Baptist Health Sciences
Winston-Salem,NC

VISITS: 3 visits in 3 months

PHASE: NA

NCT ID: NCT05030038

Impact of Aromatase Inhibitors on Gut Bacteria in People with Stage 0-IV Breast Cancer

Oral Aromatase Inhibitors Modify the Gut Microbiome Effecting Estrogen Bioavailability Scientific Title

Purpose

To study the bacteria in your gut before and during treatment with an aromatase inhibitor.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, stage III, or stage IV (metastatic) hormone receptor positive (ER+ and/or PR+) breast cancer who are receiving an aromatase inhibitor, or women without breast cancer who are receiving an aromatase inhibitor to reduce their risk of breast cancer. You must not have received antibiotics within the last month. If you have HER2 positive (HER2+) breast cancer, you must not have received an antibody drug conjugate (ADC). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood tests, 3 times within 3 months</li> <li class="seamTextUnorderedListItem">Stool samples, 3 times within 3 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The microbiome consists of the many bacteria, viruses, and fungi found in your digestive tract. Most of the microbiome consists of bacteria in your digestive system.</li> <li class="seamTextUnorderedListItem">These bacteria can be beneficial or harmful. The harmful bacteria cause disease, and the beneficial bacteria help keep you healthy.</li> <li class="seamTextUnorderedListItem">Aromatase inhibitors are a type of hormone therapy commonly used to treat hormone receptor-positive breast cancer. The approved aromatase inhibitors are anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®).</li> <li class="seamTextUnorderedListItem">You will collect fecal samples at home and either mail in the sample or drop it off at the lab.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05030038' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hsph.harvard.edu/nutritionsource/microbiome/' target='_blank'>Harvard University: What is the Microbiome?</a> </li><li class='seamTextUnorderedListItem'><a href='https://breastcancernow.org/about-us/news-personal-stories/can-gut-bacteria-help-treat-breast-cancer' target='_blank'>Breast Cancer Now: Gut Bacteria and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/aromatase-inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li></ul>

NEAREST SITE: 2314 miles
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem,NC

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05595577

Exercise to Improve Heart and Brain Function for Stage I-III Breast Cancer

Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment (PALS) Scientific Title

Purpose

To study if an exercise program helps improve exercise capability, heart function, memory, and quality of life compared to health classes.

Who is this for?

People with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy, trastuzumab (Herceptin®), immunotherapy, or radiation. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise program, 1-2 sessions every week for 6 months</li> <li class="seamTextUnorderedListItem">Heart tests, 2 times</li> <li class="seamTextUnorderedListItem">Heart MRI scan</li> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health classes, virtual or in person, 12 sessions within 6 months</li> <li class="seamTextUnorderedListItem">Heart tests, 2 times</li> <li class="seamTextUnorderedListItem">Heart MRI scan</li> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some cancer treatments can harm the heart.</li> <li class="seamTextUnorderedListItem">Exercise may improve heart and brain function and improve quality of life.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, the exercise sessions include an aerobic warm-up, strength training, aerobic exercise of increasing intensity, and cool-down with elastic bands.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, the control health classes provide information about nutrition, stress management, sleep, and a healthy lifestyle.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05595577' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2352 miles
University of Rochester
Rochester,NY

VISITS: 6 visits over 3-5 months

PHASE: NA

NCT ID: NCT03137095

Memory Problems During Chemotherapy in People with Stage I-III Breast Cancer

Longitudinal Pilot Mechanistic Study of the Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients and Non-Cancer Control Participants Scientific Title

Purpose

To study if and how your cognitive functioning skills, like memory and concentration, change as you receive chemotherapy.

Who is this for?

Women with newly diagnosed stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy, and women who do not have breast cancer. Full eligibility criteria

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You will undergo the following over 3-5 months: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">6 cognitive tests, during chemotherapy and 1 month after chemotherapy</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognitive tests study your cognition, which is your ability to think.</li> <li class="seamTextUnorderedListItem">Women without breast cancer will also be enrolled for comparison.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03137095' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/managing-cancer/side-effects/changes-in-mood-or-thinking/chemo-brain.html' target='_blank'>American Cancer Society: What is Chemo Brain?</a> </li></ul>

NEAREST SITE: 2354 miles
Integrative Cardiovasculal Physiology Laboratory, University of Florida
Gainesville,FL

VISITS: 3 visits every week for 3 months

PHASE: NA

NCT ID: NCT05848141

Rowing for Heart Health After Treatment for Women with Stage I-III Breast Cancer

Indoor Rowing as a Novel Exercise Therapy for Cardiovascular Rehabilitation in Middle-Aged and Older Breast Cancer Survivors Following Chemotherapy Scientific Title

Purpose

To study how rowing exercise affects heart health for breast cancer survivors.

Who is this for?

Women 40 to 80 years old with stage I, stage II, or stage III breast cancer who completed primary treatment between 6 months and 2 years ago. You must not have heart disease. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care</li> <li class="seamTextUnorderedListItem">Heart tests</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise with indoor rowing machine after study completion (optional)</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise with indoor rowing machine, 3 days every week for 3 months</li> <li class="seamTextUnorderedListItem">Heart tests</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast cancer treatments can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">People who have received chemotherapy and some other types of breast cancer treatment have a higher risk for heart disease that people who have not.</li> <li class="seamTextUnorderedListItem">Exercise may decrease the risk of heart disease.</li> <li class="seamTextUnorderedListItem">Each rowing exercise is about 50 minutes.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05848141' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2354 miles
Integrative Cardiovascular Physiology Laboratory, University of Florida
Gainesville,FL

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05913713

Exercise for Heart Health After Chemotherapy for Women with Stage I-III Breast Cancer

High Intensity Interval Training: Optimizing Exercise Therapy to Mitigate Cardiovascular Disease Risk Following Breast Cancer Chemotherapy Scientific Title

Purpose

To study the ability of high intensity or moderate intensity exercise to improve heart health after chemotherapy.

Who is this for?

Women 18 to 85 years old with stage I, stage II, or stage III breast cancer who completed chemotherapy between 6 months and 1.5 years ago. You must currently exercise less than 2.5 hours every week. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High intensity exercise using a stationary bike, at home, 3 days every week for 3 months</li> <li class="seamTextUnorderedListItem">Heart tests</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Moderate intensity exercise using a stationary bike, at home, 3 days every week for 3 months</li> <li class="seamTextUnorderedListItem">Heart tests</li> </ul> Group 3: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Continue routine exercise, 3 months</li> <li class="seamTextUnorderedListItem">Heart tests</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High or moderate intensity exercise using a stationary bike, at home, 3 days every week for 3 months (optional)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast cancer treatments can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">People who have received chemotherapy have a higher risk for heart disease that people who have not received chemotherapy.</li> <li class="seamTextUnorderedListItem">Exercise may decrease the risk of heart disease.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05913713' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2354 miles
University of Florida
Gainesville,FL

VISITS: Coincides with routine care

PHASE: NA

NCT ID: NCT05507879

Registry to Study Heart Problems from Chemotherapy in People with Stage I-III Breast Cancer

Characterization of TRPC6 to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure (Prospective Study) Scientific Title

Purpose

To study the TRPC6 biomarker to predict and prevent chemotherapy-related cardiac toxicity.

Who is this for?

People with stage I, stage II, or stage III breast cancer who are receiving or are planning to receive chemotherapy or trastuzumab (Herceptin®). Full eligibility criteria

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You will provide the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood samples</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast cancer treatments can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">Understanding how the TRPC6 biomarker is involved in these changes may allow early intervention against cardiac toxicity and also identify new biomarkers to protect long-term cardiac health.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05507879' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/diseases/16858-chemotherapy--the-heart-cardiotoxicity#:~:text=Cardiotoxicity%20is%20a%20term%20for,radiation%20therapy%20to%20the%20chest.' target='_blank'>Cleveland Clinic: Cardiotoxicity and Cancer Treatment</a> </li></ul>

NEAREST SITE: 2354 miles
Integrative Cardiovasculal Physiology Laboratory, University of Florida
Gainesville,FL

VISITS: At least 1 visit

PHASE: NA

NCT ID: NCT04914663

Exercise to Reduce Heart Problems During Chemotherapy for Women with Stage I-III Breast Cancer

All-extremity Exercise as a Novel Strategy for Optimizing Cardiovascular Function During Chemotherapy for Breast Cancer Scientific Title

Purpose

To study if 2 different types of exercise reduce heart problems during chemotherapy.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy. You must not be receiving a CDK4/6 inhibitor, PARP inhibitor, or radiation during chemotherapy. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Full body exercise, at home, 3 months</li> <li class="seamTextUnorderedListItem">Physical function tests</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Treadmill exercise, at home, 3 months</li> <li class="seamTextUnorderedListItem">Physical function tests</li> </ul> Group 3: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care</li> <li class="seamTextUnorderedListItem">Physical function tests</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast cancer treatments, such as chemotherapy, can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">Exercise may help reduce these heart problems.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04914663' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2354 miles
Institute on Aging; University of Florida
Gainesville,FL

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05684367

Walking to Reduce Fatigue for Older Women After Treatment

Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors (EXERGISE) Scientific Title

Purpose

To study if walking can reduce fatigue.

Who is this for?

Women at least 60 years old with stage I, stage II, or stage III breast cancer who completed treatment between 3 months and 1 year ago. You must be experiencing fatigue (feeling tired). Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking at research center, 30 minutes per session, 3 days every week for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking at home, 30 minutes per session, 5 days every week for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Many people experience fatigue (feeling tired) after cancer treatment.</li> <li class="seamTextUnorderedListItem">Older breast cancer survivors experience more fatigue than younger survivors.</li> <li class="seamTextUnorderedListItem">Aerobic exercise (such as walking) can improve fatigue in younger breast cancer survivors, but these effects are not as strong in older people. New methods are needed to reduce fatigue in older breast cancer survivors.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05684367' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2377 miles
MUSC Department of Family Medicine
Charleston,SC

VISITS: Number of visits unavailable

PHASE: IV

NCT ID: NCT06162663

Suvorexant for Sleep Problems During Hormone Therapy for Postmenopausal Women with Stage I-III Breast Cancer

Double-blind Randomized Controlled Trial Comparing Suvorexant 20 mg to Placebo for Treatment of Insomnia in Cancer Survivors Scientific Title

Purpose

To study the ability of suvorexant (Belsomra®) to improve sleep problems during hormone therapy.

Who is this for?

Postmenopausal women with stage I, stage II, or stage III breast cancer who have completed treatment within the last 1.5 months and are receiving hormone therapy with a selective estrogen receptor modulator (SERM) or an aromatase inhibitor. You must be experiencing sleep problems. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Suvorexant (Belsomra®), by mouth, daily for 1 month</li> <li class="seamTextUnorderedListItem">Educational information about sleep</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times within 1 month</li> </ul> Group 2: Placebo <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for suvorexant (Belsomra®), by mouth, daily for 1 month</li> <li class="seamTextUnorderedListItem">Educational information about sleep</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times within 1 month</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer survivors have an increased risk of sleep problems compared to the general population.</li> <li class="seamTextUnorderedListItem">Insomnia is difficulty falling asleep, staying asleep, or waking up too early.</li> <li class="seamTextUnorderedListItem">Suvorexant (Belsomra®) is an FDA approved drug to improve sleep issues. It may also help breast cancer survivors improve their sleep.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06162663' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2383 miles
Mayo Clinic in Florida
Jacksonville,FL

VISITS: At least 2 visits

PHASE: NA

NCT ID: NCT06401889

Improving Skin and Quality of Life During Hormone Therapy for Women with Stage 0-III Breast Cancer

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy Scientific Title

Purpose

To study changes in skin quality and self-esteem during hormone therapy after meeting with an aesthetician.

Who is this for?

Postmenopausal women with stage 0 (DCIS), stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who are planning to receive one of the following aromatase inhibitors: letrozole (Femara®), anastrozole (Arimidex®), or exemestane (Aromasin®). You must not have received chemotherapy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visits with aesthetician</li> <li class="seamTextUnorderedListItem">Skin photos and measurements</li> <li class="seamTextUnorderedListItem">Surveys</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Skin quality may change after beginning to receive an aromatase inhibitor, such as letrozole (Femara®), anastrozole (Arimidex®), or exemestane (Aromasin®).</li> <li class="seamTextUnorderedListItem">Skin changes may affect a person's self-esteem.</li> <li class="seamTextUnorderedListItem">Aestheticians are skin care professionals. </li> <li class="seamTextUnorderedListItem">Meeting with an aesthetician may improve skin quality and therefore self-esteem.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06401889' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2383 miles
Mayo Clinic in Florida
Jacksonville,FL

VISITS: 3 visits within 1 year

PHASE: NA

NCT ID: NCT06106282

Reducing Bone and Joint Problems During Hormone Therapy for Women with Stage 0-III Breast Cancer

Breast Cancer Survivors Who Experience Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS): A Multidisciplinary Pain Program Designed to Decrease Pain and Improve Functioning, Mood, and Medication Adherence. (AIMSS) Scientific Title

Purpose

To study a behavioral program designed to reduce pain, improve mood, improve functioning, and improve the ability to take medication as recommended.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who have been receiving an aromatase inhibitor for between 6 months and 7 years. You must be experiencing bone or joint problems and be receiving your care at Mayo Clinic in Jacksonville, Florida. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Behavioral program, in person, for 2 days</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®) are types of hormone therapy called aromatase inhibitors. Aromatase inhibitors block some production of estrogen that helps cancer grow.</li> <li class="seamTextUnorderedListItem">These drugs may cause bone problems or joint pain or stiffness as side effects.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06106282' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/aromatase-inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li></ul>

NEAREST SITE: 2406 miles
University of North Carolina at Chapel Hill, Department of Radiation Oncology
Chapel Hill,NC

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT04073966

Studying Brain Function Changes During Radiation in People with Brain Metastases

Magnetic Resonance Imaging Biomarkers for Radiation-Induced Neurocognitive Decline Following Stereotactic Radiosurgery of Newly Diagnosed Brain Metastases: An Observational Pilot Study Scientific Title

Purpose

To study why radiation causes brain function changes to help doctors predict and prevent brain function changes.

Who is this for?

People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis) who are receiving stereotactic radiosurgery (SRS). You must not have received surgery to the lesion receiving SRS or any radiation to the brain or head. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI scans</li> <li class="seamTextUnorderedListItem">Neurocognitive function tests</li> </ul> Please contact research site for trial schedule
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic radiosurgery (SRS) is a type of radiation therapy that delivers a high dose of radiation only to the areas of cancer in the brain and avoids the surrounding normal brain tissue.</li> <li class="seamTextUnorderedListItem">A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04073966' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>

NEAREST SITE: 2433 miles
Sibley Memorial Hospital
Washington,DC

VISITS: 4 visits within 1 year 2 months

PHASE: NA

NCT ID: NCT05780814

Improving Sleep Problems and Weight Loss for Women After Treatment

The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer (COIN) Scientific Title

Purpose

To study the ability of a cognitive behavioral therapy (CBT) program to improve sleep problems before losing weight.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who were diagnosed within the last 10 years and have completed treatment (except hormone therapy). You must also be overweight (BMI > 25), planning to lose weight, and experiencing sleep problems. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cognitive behavioral therapy (CBT) sessions to improve sleep, virtual, 6 times within 2 months</li> <li class="seamTextUnorderedListItem">Videos about weight loss, 19 videos</li> <li class="seamTextUnorderedListItem">Electronic sleep diary, 1 week</li> <li class="seamTextUnorderedListItem">Body measurements, 4 times</li> <li class="seamTextUnorderedListItem">DEXA scans, 2 times</li> <li class="seamTextUnorderedListItem">Smart watch</li> <li class="seamTextUnorderedListItem">Questionnaires, 5 times</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education sessions about sleep and cancer, virtual, 6 times within 2 months</li> <li class="seamTextUnorderedListItem">Body measurements, 4 times</li> <li class="seamTextUnorderedListItem">DEXA scans, 2 times</li> <li class="seamTextUnorderedListItem">Smart watch</li> <li class="seamTextUnorderedListItem">Questionnaires, 5 times</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The cognitive behavioral therapy (CBT) program combines education and behavioral techniques to reduce sleep problems (insomnia).</li> <li class="seamTextUnorderedListItem">Cognitive behavioral therapy (CBT) is a type of therapy that focuses on the relationship between thoughts, feelings, and behaviors.</li> <li class="seamTextUnorderedListItem">All participants will follow a program with the goals of increasing physical activity, improving diet, and losing weight.</li> <li class="seamTextUnorderedListItem">Wearable devices such as smart watches and FitBits are used to track your physical activity.</li> <li class="seamTextUnorderedListItem">A DEXA scan measures fat, muscle, and bone density.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05780814' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2433 miles
Sibley Memorial Hospital
Washington,DC

VISITS: No visits required

PHASE: NA

NCT ID: NCT05560685

Smartphone App Surveys to Report Side Effects of Hormone Therapy for Women with Stage I-III HR+ Breast Cancer

SMART-ER: A Pilot Study to Assess the Feasibility of Symptom Monitoring With Patient-reported Outcomes Collected Via Smart Phone App in Patients With Estrogen and/or Progesterone Receptor-positive Stage I-III Breast Cancer at Risk for Adjuvant Endocrine Therapy Non-adherence or Early Discontinuation Scientific Title

Purpose

To study if reporting hormone therapy side effects through surveys in a smartphone app will improve side effect management and the ability to take hormone therapy as recommended.

Who is this for?

Women with stage I, stage II, or stage III hormone receptor positive (ER+ or ER low and/or PR+ or PR low) breast cancer who are planning to receive tamoxifen (Nolvadex®), anastrozole (Arimidex®), exemestane (Aromasin®), or letrozole (Femara®) hormone therapy. You must be receiving care at Sibley Memorial Hospital or Johns Hopkins. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Complete surveys in smartphone app, 5 times within 4 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Side effects are a major reason why some people do not take their hormone therapy as recommended.</li> <li class="seamTextUnorderedListItem">The research team will be alerted if you report severe or worsening side effects.</li> <li class="seamTextUnorderedListItem">You will be offered information about ways to manage side effects.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05560685' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2433 miles
Sibley Memorial Hospital
Washington,DC

VISITS: 1 visit every week for 1 month

PHASE: NA

NCT ID: NCT06536881

Fasting to Improve Adherence to Chemotherapy for Women with Stage I-III Breast Cancer

Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming (GAMMER) Study in Early Stage Breast Cancer Receiving Chemotherapy Scientific Title

Purpose

To study if fasting (not eating) for 1-2 days during chemotherapy helps women continue receiving chemotherapy as prescribed.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who are planning to receive one of the following chemotherapy treatments: dose dense doxorubicin (Doxil®) and cyclophosphamide (Cytoxan®) (called ddAC) or docetaxel (Taxotere®) and cyclophosphamide (Cytoxan®) (called TC). Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fast (not eat, except for water) for 1-2 days during chemotherapy</li> <li class="seamTextUnorderedListItem">Stool (poop) samples, weekly for 3 weeks</li> <li class="seamTextUnorderedListItem">Blood samples, weekly for 1 month</li> <li class="seamTextUnorderedListItem">Questionnaires, weekly for 1 month</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Previous research suggests that fasting during chemotherapy is safe and can prevent some toxic effects of chemotherapy without causing chronic weight loss.</li> <li class="seamTextUnorderedListItem">Fasting may allow people to experience less issues during chemotherapy (tolerance) and receive chemotherapy as prescribed (adherence).</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06536881' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2454 miles
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore,MD

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05386719

Screening for Diabetes, High Cholesterol, and Heart Disease in People with Breast Cancer After Treatment

A Cardiometabolic Screening Program for Breast Cancer Survivors Scientific Title

Purpose

To study a screening program for prediabetes, diabetes, high cholesterol, and heart disease in breast cancer survivors, as well as a program to direct people to resources for management.

Who is this for?

People with stage I, stage II, or stage III breast cancer who completed treatment at least 3 months ago. You must be receiving care at Johns Hopkins Medical Institute; Sidney Kimmel Comprehensive Cancer Center in Baltimore, MD; Green Spring Station in Lutherville-Timonium, MD; or Sibley Memorial Hospital in Washington, DC. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood tests, 1-2 times in 1 year</li> <li class="seamTextUnorderedListItem">Referral to primary care, nutrition, exercise, hormone health, and/or heart health provider(s) based on risk factors</li> <li class="seamTextUnorderedListItem">Educational handouts based on risk factors</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Prediabetes, diabetes, high cholesterol, and being overweight/obese are common in people with early stage breast cancer.</li> <li class="seamTextUnorderedListItem">The Healthful Eating, Activity and Weight Program (HEAWP) and Cardiovascular Disease Prevention Program are designed to help people manage these conditions.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05386719' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/gim/clinical/lifestyle-weight/' target='_blank'>Johns Hopkins: Healthful Eating, Activity and Weight Program</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/wellness-and-prevention/preventing-cardiovascular-diseases' target='_blank'>Johns Hopkins: Preventing Cardiovascular Diseases</a> </li></ul>

NEAREST SITE: 2531 miles
Virtua Health
Voorhees,NJ

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05704842

Exercise to Reduce Fatigue During Chemotherapy for Women with Stage I-III Breast Cancer

Pilot Study to Evaluate the Impact of a Home-Based Exercise Program on Cancer-Related Fatigue in Breast Cancer Patients Undergoing Curative-Intent Chemotherapy Scientific Title

Purpose

To study if exercise reduces fatigue during treatment with chemotherapy.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who plan to receive chemotherapy. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visit with physical therapist</li> <li class="seamTextUnorderedListItem">Complete home-based exercise program</li> <li class="seamTextUnorderedListItem">Complete online surveys, weekly</li> </ul> Group 2: Standard Treatment <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Complete online surveys, weekly</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The home-based exercise program includes exercises such as: core stabilization, core extension, leg extensions, squats with and without weights, shoulder exercises, and arm exercises.</li> <li class="seamTextUnorderedListItem">The online surveys will assess your symptoms and fatigue.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05704842' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/fatigue' target='_blank'>Breastcancer.org: Cancer Fatigue</a> </li></ul>

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05910294

Preventing and Improving Sexual Health Concerns for People with DCIS and Stage I-III Breast Cancer

Randomized Pilot Prevention Trial to Improve Sexual and Vulvovaginal Health Concerns in Premenopausal Female Breast Cancer Patients Receiving Ovarian Suppression Scientific Title

Purpose

To study whether sexual health counseling and using a non-hormonal vaginal moisturizer at the start of hormone therapy may prevent or reduce sexual side effects.

Who is this for?

Premenopausal or perimenopausal women with stage 0 (DCIS), stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who are receiving or planning to receive hormone therapy. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Receive recommendations for vaginal moisturizers</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sexual health counseling</li> <li class="seamTextUnorderedListItem">Receive non-hormonal moisturizers, 3-5 times per week</li> <li class="seamTextUnorderedListItem">Consultation with pelvic floor physical therapist</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">If you are in group 1, you will receive recommendations for vaginal moisturizers but will purchase the moisturizers at your local pharmacy.</li> <li class="seamTextUnorderedListItem">If you are in group 2, you will receive non-hormonal vaginal moisturizers, such as: Hyalogyn, Replens, Liquibeads, or Vitamin E capsules.</li> <li class="seamTextUnorderedListItem">Sexual side effects include vaginal dryness and sexual dysfunction.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05910294' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/sex-intimacy' target='_blank'>Breastcancer.org: Sexual Health During and After Breast Cancer</a> </li></ul>

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT06144164

Managing Lymphedema After Lymph Node Surgery for Women with Stage I-III Breast Cancer

A Prospective Cohort Study of Patients Undergoing ALND for Treatment of Breast Cancer: The Efficacy of a Comprehensive Prevention Program in Decreasing the Incidence of Lymphedema and Improving Quality of Life Scientific Title

Purpose

To study the ability of a lymphedema prevention program to help lymph fluid drain out of the arm, prevent lymphedema, and improve quality of life.

Who is this for?

Women 18-75 years old with stage I, stage II, or stage III breast cancer who are planning to receive axillary lymph node dissection or sentinel lymph node biopsy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Immediate lymphatic reconstruction (ILR) during lymph node surgery</li> <li class="seamTextUnorderedListItem">Lymphatic massage, at home, 3 times every week for 3 months</li> <li class="seamTextUnorderedListItem">Compression garments, daily for 3 months</li> <li class="seamTextUnorderedListItem">Arm measurements, up to 2 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is the build up of fluid and abnormal swelling of the arm (in the case of axillary lymph node dissection or sentinel lymph node biopsy surgery).</li> <li class="seamTextUnorderedListItem">Lymphedema is caused by damage to the lymphatic system and inability to drain excess lymph fluid.</li> <li class="seamTextUnorderedListItem">Immediate Lymphatic Reconstruction (ILR) is a procedure to rebuild damaged lymphatic system.</li> <li class="seamTextUnorderedListItem">Lymphatic massage may help reduce swelling in your body.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06144164' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/about-your-immediate-lymphatic-reconstruction-ilr-procedure#:~:text=ILR%20is%20a%20procedure%20to,your%20axillary%20lymph%20node%20dissection.' target='_blank'>Memorial Sloan Kettering Cancer Center: About Your Immediate Lymphatic Reconstruction (ILR) Procedure</a> </li></ul>

NEAREST SITE: 2541 miles
RWJBarnabas Health - Robert Wood Johnson University Hospital, Hamilton
Hamilton,NJ

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT05559164

Reducing Treatment-Related Heart Problems From Anti-HER2 Targeted Therapy

STACIE: Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted Therapy Scientific Title

Purpose

To study whether atorvastatin (Lipitor®) reduces treatment delays or early discontinuations of anti-HER2 targeted therapy due to treatment-related heart problems.

Who is this for?

Women with stage I, stage II, or stage III HER2 positive (HER2+) breast cancer who are planning to receive treatment with anti-HER2 targeted therapy. You must not currently be receiving any cholesterol drugs. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Atorvastatin (Lipitor®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Questionnaires, 4 times within 1.25 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast cancer treatments including anti-HER2 targeted therapy can cause or increase the risk of heart problems, which is called cardiotoxicity. </li> <li class="seamTextUnorderedListItem">Atorvastatin (Lipitor®) is a cholesterol drug called a statin. Statins lower <q>bad cholesterol</q> which may reduce the risk of heart problems.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05559164' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted-therapy/what-are-anti-her2-therapies' target='_blank'>Breastcancer.org: Anti-HER2 Targeted Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045772' target='_blank'>Mayo Clinic: Statins Including Atorvastatin (Lipitor®)</a> </li></ul>

NEAREST SITE: 2567 miles
Memorial Sloan Kettering Cancer Center (All protocol activites)
New York,NY

VISITS: 10 visits in 2.5 months

PHASE: NA

NCT ID: NCT06814977

Acupuncture for Joint Pain for Hispanic or Black Women with Stage I-III Breast Cancer

Researching the Implementation of Acupuncture for Aromatase Inhibitor-related Arthralgias in Diverse Underserved Breast Cancer Survivors (ReIMAGINE) Scientific Title

Purpose

To study whether acupuncture can treat joint pain caused by hormone therapy.

Who is this for?

Black or Hispanic women or transgender males, with stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who have completed primary treatment at least 1 month ago and are receiving an aromatase inhibitor. You must be experiencing joint pain. Full eligibility criteria

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You will be assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acupuncture, weekly for 2.5 months</li> </ul> Group 2: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Usual care</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aromatase inhibitors are letrozole (Femara®), anastrozole (Arimidex®), and exemestane (Aromasin®).</li> <li class="seamTextUnorderedListItem">Aromatase inhibitors can cause pain such as joint pain.</li> <li class="seamTextUnorderedListItem">Acupuncture is a drug-free treatment that may ease pain.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06814977' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2567 miles
Memorial Sloan Kettering Cancer Center
New York,NY

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT06037954

Improving Mental Health for Older Adults with Breast Cancer

Mental Health Care Initiation Intervention for Older Adults With Cancer Scientific Title

Purpose

To study the ability of the Open Door for Cancer (OD-C) approach to improve mental health for older adults with breast cancer.

Who is this for?

People with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who were diagnosed at age 65 or older and are currently receiving treatment. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Open Door for Cancer (OD-C) approach, by phone or videoconference, 3 sessions within 1.5 months</li> </ul> Group 2: Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Mental health screening</li> <li class="seamTextUnorderedListItem">Referrals to support resources</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Open Door for Cancer (OD-C) approach includes the following: 1) Provide education about depression and treatment options; 2) Identify treatment preferences and a personal goal achievable with mental health care; 3) Assess barriers to starting treatment; 4) Referrals to additional support; 5) Address barriers to accessing care.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06037954' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/taking-care-of-mental-health/how-breast-cancer-affects-mental-health' target='_blank'>Breastcancer.org: How Breast Cancer Can Affect Mental Health</a> </li></ul>

NEAREST SITE: 2569 miles
Columbia University Medical Center
New York,NY

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05496829

Improving Adherence to Hormone Therapy and Heart Disease Medication for People with Stage I-III Breast Cancer

IMPACT Trial: Intervention to iMProve AdherenCe Equitably Scientific Title

Purpose

To study whether a patient portal and smartphone reminder app help people adhere to treatment with hormone therapy and heart disease medication.

Who is this for?

People with stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who are receiving treatment with hormone therapy and at least 1 medication for high blood pressure or high cholesterol to prevent heart disease. You must self-report that you do not take your medication as frequently as prescribed. You must receive care from a primary care provider or cardiologist within the New York Presbyterian Health System. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Access to patient portal with training from pharmacist</li> <li class="seamTextUnorderedListItem">Access to smartphone reminder app</li> </ul> Group 2: Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No access to patient portal or smartphone reminder app</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hormone therapy is a common treatment for hormone receptor positive (HR+) breast cancer.</li> <li class="seamTextUnorderedListItem">Antihypertensive medications are used to treat high blood pressure and statins are used to treat high cholesterol to prevent heart disease.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05496829' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy' target='_blank'>Breastcancer.org: Hormone Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/treatments/21811-antihypertensives' target='_blank'>Cleveland Clinic: Antihypertensive Medications</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/treatments/22282-statins' target='_blank'>Cleveland Clinic: Statins</a> </li></ul>

NEAREST SITE: 2573 miles
Cleveland Clinic Florida
Weston,FL

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05598879

Registry to Study Cardiovascular Health and Risk Factors in People with Breast Cancer

Global Cardio Oncology Registry Scientific Title

Purpose

To collect information on the diagnosis and treatment of cardiovascular health and risk factors in people with breast cancer.

Who is this for?

People with stage I, stage II, stage III, or stage IV (metastatic) breast cancer. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Collection of health information</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some breast cancer treatments can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">This study uses clinical, laboratory, imaging, demographic, and socioeconomic information to study cardiovascular (heart and blood vessels) health and risk factors before, during, or after cancer treatment.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05598879' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.heart.org/en/news/2020/02/19/what-women-need-to-know-about-breast-cancer-and-heart-disease' target='_blank'>American Heart Association: Breast Cancer and Heart Disease</a> </li></ul>

NEAREST SITE: 2574 miles
Montefiore Medical Center
Bronx,NY

VISITS: Coincides with surgery

PHASE: NA

NCT ID: NCT06524895

Reiki Before Surgery for Women with Stage 0-III Breast Cancer Who Live in Bronx County, NY

Pilot Study of Medical Reiki for Women Undergoing Surgery for Breast Cancer: Impact on Quality of Life, Medical Recovery Metrics, and Cortisol Scientific Title

Purpose

To study the impact of reiki before surgery on surgery recovery, quality of life, and stress.

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who are planning to receive a mastectomy. You must live in Bronx County, New York. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Reiki, before surgery</li> </ul> Group 2: Placebo <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for reiki, before surgery</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Reiki is a form of energy therapy involving light touch. It is a process of targeting the energy fields around the patient's body and is believed to stimulate the patient's natural ability to heal itself.</li> <li class="seamTextUnorderedListItem">Reiki is a safe treatment that emphasizes spirituality in healing and wellness whose origins are rooted in ancient Tibetan traditions.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06524895' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2574 miles
Montefiore Medical Center
Bronx,NY

VISITS: At least 2 visits

PHASE: NA

NCT ID: NCT05213936

Improving Scalp Cooling and Reducing Hair Loss During Chemotherapy for Stage I-III Breast Cancer

Scalp Cooling for Chemotherapy-Induced Alopecia in Patients of Color: A Clinical and Mechanistic Study Scientific Title

Purpose

To determine if hairstyles can improve the ability of a scalp cooling cap to decrease hair loss.

Who is this for?

People with stage I, stage II, or stage III breast cancer with type 3 (curly) or type 4 (kinky-curly) hair who are planning to receive paclitaxel (Taxol®) or docetaxel (Taxotere®) chemotherapy. You must not have received or be planning to receive doxorubicin (Doxil®). Full eligibility criteria

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You will be assigned to 1 of 3 groups: Group 1: Scalp Cooling with Hairstyles <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Wear scalp cooling cap with braids, twists, or cornrows</li> <li class="seamTextUnorderedListItem">Hair samples and examinations</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Scalp Cooling with Water and Conditioner <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Wear scalp cooling cap with water and conditioner on the hair and scalp</li> <li class="seamTextUnorderedListItem">Hair samples and examinations</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 3: No Scalp Cooling <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No scalp cooling</li> <li class="seamTextUnorderedListItem">Hair samples and examinations</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Scalp cooling helps prevent hair loss due to chemotherapy.</li> <li class="seamTextUnorderedListItem">Scalp cooling may be less effective in people of color because their hair type can prevent the scalp cooling cap from making contact with the scalp.</li> <li class="seamTextUnorderedListItem">Hairstyles such as cornrows, braids, or twists or the use of water and conditioner on the hair and scalp may increase contact of the scalp cooling cap with the scalp, help the cap work better, and may therefore help prevent hair loss.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, you can choose from receiving braids, twists, or cornrows.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with lung cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05213936' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2591 miles
University of Miami
Miami,FL

VISITS: Coincides with routine care

PHASE: NA

NCT ID: NCT04650256

Chinese Herbal Product to Reduce Pain and Itching from Radiation for Women with Stage II-III Breast Cancer

Application of Chinese Herbal Complementary and Alternative Medicine (CAM) to Improve Human Health and to Further Botanical and Horticultural Sciences Scientific Title

Purpose

To study a Chinese herbal product for the temporary relief of pain and itching after radiation.

Who is this for?

Women with stage II or some stage III breast cancer who have received a mastectomy and are planning to receive radiation. Full eligibility criteria

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You will complete the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rub product on your chest skin, daily for 4.5 months</li> <li class="seamTextUnorderedListItem">Surveys</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Chinese herbal product in this study is an over the counter (available without a prescription) product with 1% menthol.</li> <li class="seamTextUnorderedListItem">You will apply the product to your skin 2 times every day during radiation and continue for up to 3 months after radiation is complete.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04650256' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2591 miles
University of Miami
Miami,FL

VISITS: 2 visits within 1 month

PHASE: II

NCT ID: NCT05812924

Platelet-Rich Plasma for Vaginal and Urinary Health in Women During or After Breast Cancer Treatment

A Novel Therapy for Breast Cancer Survivors With Genitourinary Syndrome of Menopause Scientific Title

Purpose

To study the ability of platelet-rich plasma (PRP) injections to improve symptoms of genitourinary syndrome of menopause (GSM).

Who is this for?

Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who are receiving treatment or have completed treatment. You must have abnormal urinary, genital, and sexual health symptoms. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Platelet-rich plasma (PRP), by injection into the vagina, 2 times</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Genitourinary syndrome of menopause (GSM) refers to symptoms of abnormal urinary, genital, and sexual function. GSM can have a negative effect on a woman's quality of life.</li> <li class="seamTextUnorderedListItem">GSM can occur with natural menopause and in women who have received hormone therapy for breast cancer. Both natural menopause and hormone therapy greatly decrease the body's ability to make estrogen, and this can lead to GSM.</li> <li class="seamTextUnorderedListItem">Platelet-rich plasma (PRP) is obtained from your own blood and returned to your body to restore vaginal and urinary health.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05812924' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://consultqd.clevelandclinic.org/genitourinary-syndrome-of-menopause-in-breast-cancer-survivors/' target='_blank'>Cleveland Clinic: Genitourinary Syndrome of Menopause in Breast Cancer Survivors</a> </li><li class='seamTextUnorderedListItem'><a href='https://hf.org/healthcare-home/departments-services/womens-health/gynecology/prp-vaginal-rejuvenation#what-is-prp-therapy-' target='_blank'>Health First: Platelet-Rich Plasma for Vaginal and Urinary Health</a> </li></ul>

NEAREST SITE: 2619 miles
Dartmouth-Hitchcock Clinic
Lebanon,NH

VISITS: At least 2 visits within 3 months

PHASE: NA

NCT ID: NCT06258993

Promoting Exercise After Treatment for People With Stage 0-III Breast Cancer

Increasing Physical Activity Among Breast Cancer Survivors: Use of the ORBIT Model to Refine and Test a Novel Approach to Exercise Promotion Based on Affect-regulation (Study 2) Scientific Title

Purpose

To study the ability of 2 exercise programs to increase physical activity for breast cancer survivors.

Who is this for?

People with stage 0 (DCIS), stage I, stage II, or stage III breast cancer who have completed treatment within the last 5 years. You must exercise less than 1 hour every week over the last 6 months. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Affect-Based Exercise <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visit to discuss exercise program, 2 times</li> <li class="seamTextUnorderedListItem">Exercise program</li> <li class="seamTextUnorderedListItem">Affect-based exercise, up to 2.5 hours every week for 3 months</li> <li class="seamTextUnorderedListItem">Wear a smart watch</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Effort-Based Exercise <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visit to discuss exercise program, 2 times</li> <li class="seamTextUnorderedListItem">Exercise program</li> <li class="seamTextUnorderedListItem">Effort-based exercise, up to 2.5 hours every week for 3 months</li> <li class="seamTextUnorderedListItem">Wear a smart watch</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise may improve fatigue, pain, quality of life, and sleep in people treated for breast cancer.</li> <li class="seamTextUnorderedListItem">The exercise program includes definitions of exercise, guidelines for safe exercise, and strategies to overcome barriers to exercise. You will also be asked to describe your previous exercise and will be given an exercise plan.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, you will be asked to <q>select a pace of exercise that makes you feel as good as possible.</q></li> <li class="seamTextUnorderedListItem">If you are in Group 2, you will be asked to <q>select a pace that would make it challenging for you to carry on more than a short conversation.</q></li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06258993' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2691 miles
Massachusetts General Hospital
Boston,MA

VISITS: Coincides with standard follow-up care

PHASE: NA

NCT ID: NCT01521741

Impact of Lymphedema on Quality of Life After Breast Cancer

Prospective Analysis of Symptoms, Functionality and Quality of Life Questionnaires to Evaluate Lymphedema in Patients Following Treatment for Breast Cancer. Scientific Title

Purpose

To determine how the symptoms and functional disability that accompany lymphedema can impact breast cancer survivors' quality of life.

Who is this for?

Women with breast cancer without axillary lymph node malignancy. Full eligibility criteria

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All participants will complete the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires and arm measurements</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer treatments can result in long-term, painful swelling of the arm and hand, a condition called lymphedema.</li> <li class="seamTextUnorderedListItem">To be eligible, participants must be planning to have surgery and receive follow-up care for breast cancer at Massachusetts General Hospital.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01521741' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/lymphedema' target='_blank'>BreastCancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq#section/all' target='_blank'>National Cancer Institute: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/lymphedema.html' target='_blank'>American Cancer Society: Lymphedema</a> </li></ul>

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: 4 visits over 8 months

PHASE: NA

NCT ID: NCT05327452

Exercise During Chemotherapy for Black and Hispanic People with Breast Cancer

Testing Home-based Exercise Strategies to Improve Exercise Participation and Cardiovascular Health in Underserved Minority Patients With Cancer Undergoing Chemotherapy: the THRIVE Study Scientific Title

Purpose

To determine whether an exercise intervention will affect physical activity levels and heart health in Black and Hispanic people with breast cancer.

Who is this for?

Black and Hispanic people newly diagnosed with stage I, stage II, or stage III breast cancer who are overweight/obese, engage in less than 90 minutes of exercise per week, and are planning to receive chemotherapy. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Virtually supervised home-based exercise, 3 times per week for 4 months</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Unsupervised home-based exercise, 3 times per week for 4 months</li> <li class="seamTextUnorderedListItem">Telehealth call with certified exercise trainer, 1 time per week for 4 months</li> </ul> Group 3 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Home-based stretching, 3 times per week for 4 months</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cardiovascular and strength tests, 3 times within 8 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times within 8 months</li> </ul> All groups require 4 visits
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The home-based exercise interventions include aerobic and resistance exercises.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, the virtual supervision will occur via Zoom.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05327452' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/exercise' target='_blank'>Breastcancer.org: Exercise</a> </li></ul>

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT04379414

YES Portal for Monitoring Symptoms and Providing Support for Women Ages 18-39 with Breast Cancer

Young, Empowered & Strong (YES): The Young Women's Breast Cancer Study 2- Focus on Newly Diagnosed/Metastatic Intervention Scientific Title

Purpose

To study the ability of the web-based YES portal to monitor cancer symptoms and provide support and educational resources.

Who is this for?

Women newly diagnosed with stage 0 (DCIS), stage I, stage II, stage III, or stage IV (metastatic) breast cancer between the ages of 18-39 years who are planning to receive treatment at Dana-Farber Cancer Institute. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Access to YES portal, weekly for 3 months, then monthly</li> <li class="seamTextUnorderedListItem">Surveys, every 6 months for 3 years, then yearly for 2 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Young, Empowered, and Strong (YES) portal is a web-based portal designed to help monitor cancer-related issues and to share self-management information, resources, and potential research opportunities.</li> <li class="seamTextUnorderedListItem">The portal is also designed to create a community among participants through the yeschat.org discussion board.</li> <li class="seamTextUnorderedListItem">The portal can be accessed by smartphone, tablet, or laptop/desktop.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04379414' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.dana-farber.org/clinical-trials2/detail/20-124/' target='_blank'>Dana-Farber Cancer Institute Trial Information Page: YES Portal</a> </li><li class='seamTextUnorderedListItem'><a href='https://youngandstrong.dana-farber.org/' target='_blank'>Dana-Farber Cancer Institute: Young and Strong</a> </li><li class='seamTextUnorderedListItem'><a href='https://ascopubs.org/doi/abs/10.1200/CCI.21.00067' target='_blank'>Abstract: YES Portal</a> </li></ul>

NEAREST SITE: 2693 miles
Brigham and Women's Hospital
Boston,MA

VISITS: At least 3 visits in 9 months

PHASE: NA

NCT ID: NCT04724499

Exercise to Improve Brain and Heart Health During Chemotherapy for Women with Stage I-III Breast Cancer

Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy (The CLARITY Trial) Scientific Title

Purpose

To study if a high-intensity exercise program will improve brain health, heart function, and quality of life.

Who is this for?

Women newly diagnosed with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy before surgery (neoadjuvant). You must exercise less than 1 hour every week. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High-intensity exercise on stationary bike, in person or virtual, 3 times every week, 4 months</li> <li class="seamTextUnorderedListItem">MRI scans, 3 times within 9 months</li> <li class="seamTextUnorderedListItem">Bone scans</li> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Fitness tests</li> <li class="seamTextUnorderedListItem">Surveys</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stretching, at home, 4 months</li> <li class="seamTextUnorderedListItem">MRI scans, 3 times in 9 months</li> <li class="seamTextUnorderedListItem">Bone scans</li> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Fitness tests</li> <li class="seamTextUnorderedListItem">Surveys</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">High-intensity exercise on stationary bike, in person or virtual, 3 times every week, 4 months (optional)</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some people experience problems with brain function after chemotherapy.</li> <li class="seamTextUnorderedListItem">Some breast cancer treatments, such as chemotherapy, can cause or increase the risk of heart problems, which is called cardiotoxicity.</li> <li class="seamTextUnorderedListItem">Exercise may help improve brain function and heart function.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04724499' target='_blank'>ClinicalTrials.gov</a> </li></ul>

NEAREST SITE: 2698 miles
Mass General/North Shore Center for Outpatient Care
Danvers,MA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05837598

Improving Cancer Care and Mental Health Care for People with Newly Diagnosed Stage I-IV Breast Cancer

Adapting the Tumor Board Model for Mental Illness and Cancer: A Single Arm Pilot Trial Scientific Title

Purpose

To study whether a virtual tumor board can improve cancer care and mental health care.

Who is this for?

People with newly diagnosed stage I, stage II, stage III, or stage IV (metastatic) breast cancer. You must also have one of the following mental illnesses: schizophrenia, bipolar disorder, or major depressive disorder. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Assessment of your needs, values, mental health symptoms, and barriers to care</li> <li class="seamTextUnorderedListItem">Recommendations from the virtual tumor board to help you receive the care you need</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A tumor board is a group of doctors and other health care providers that meets regularly at the hospital to discuss cancer cases and share knowledge.</li> <li class="seamTextUnorderedListItem">A virtual cancer and mental health tumor board may help people access the cancer and mental health care they need.</li> <li class="seamTextUnorderedListItem">The tumor board will notify your doctor with treatment and care recommendations.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05837598' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.net/blog/2017-07/what-tumor-board-expert-qa' target='_blank'>ASCO: What is a Tumor Board?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mhanational.org/cancer-and-mental-health' target='_blank'>Mental Health America: Cancer and Mental Health</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2020/lung-cancer-treating-mental-health-longer-survival' target='_blank'>National Cancer Institute: Study Links Mental Health Treatment to Improved Cancer Survival</a> </li></ul>

No Travel Required

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT04379570

Telephone and Online Support for Women with Stage I-III, HR+, HER2- Breast Cancer Taking Anti-Estrogen Therapy

Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions Scientific Title

Purpose

To study if different types of telephone and online education can help women take their anti-estrogen therapy.

Who is this for?

Women with stage I, stage II or stage III hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who have started taking anti-estrogen therapy within the last 6 months or intend to start taking it within the next 6 weeks. Full eligibility criteria

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You will be randomly assigned to 1 of 4 groups and receive the following: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Online education about anti-estrogen therapy, 1 time</li> <li class="seamTextUnorderedListItem">Text message reminders to take anti-estrogen therapy, daily, for 9 months</li> <li class="seamTextUnorderedListItem">Test messages asking about side effects and taking anti-estrogen therapy, monthly, for 9 months</li> <li class="seamTextUnorderedListItem">Questionnaires </li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Online education about anti-estrogen therapy, 1 time</li> <li class="seamTextUnorderedListItem">Motivational telephone therapy sessions, 5 times, over 9 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 3 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Online education about anti-estrogen therapy, 1 time</li> <li class="seamTextUnorderedListItem">Text message reminders to take anti-estrogen therapy, daily, for 9 months</li> <li class="seamTextUnorderedListItem">Test messages asking about side effects and taking anti-estrogen therapy, monthly, for 9 months</li> <li class="seamTextUnorderedListItem">Motivational telephone therapy sessions, 5 times, over 9 months</li> <li class="seamTextUnorderedListItem">Questionnaires </li> </ul> Group 4 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Online education about anti-estrogen therapy, 1 time</li> <li class="seamTextUnorderedListItem">Optional online education about healthy living</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This trial is studying whether text messaging, online education, and telephone support can help women take their anti-estrogen therapy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04379570' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/expect' target='_blank'>Breastcancer.org: Hormonal Therapy, What to Expect</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT06938555

Fasting at Night to Improve Cognition After Chemotherapy for People with Stage I-IV Breast Cancer

The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors (RESTORE) Scientific Title

Purpose

To study how fasting at night affects health, quality of life, and cognitive ability.

Who is this for?

Women with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who completed chemotherapy at least 3 months ago and who are having cognitive (thinking) problems. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fast at night, 6 nights every week for 2 months</li> <li class="seamTextUnorderedListItem">Health education videos, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Cognitive tests, 2 times in 2 months</li> <li class="seamTextUnorderedListItem">Surveys, 2 times in 2 months</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health education videos, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Cognitive tests, 2 times in 2 months</li> <li class="seamTextUnorderedListItem">Surveys, 2 times in 2 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">When you are fasting, you are still allowed to drink water, coffee, and tea.</li> <li class="seamTextUnorderedListItem">Cognitive problems are problems with thinking (cognition).</li> <li class="seamTextUnorderedListItem">This trial's enrollment will be racially diverse (at least 50% of participants will be Black, Hispanic, and/or Native American).</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06938555' target='_blank'>ClinicalTrials.gov</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05715255

Counseling by Phone to Help Manage Side Effects of Immunotherapy for Stage II-IV Breast Cancer

Adaptive Symptom Self-Management to Reduce Psychological Distress and Improve Symptom Management for Survivors on Immune Checkpoint Inhibitors Scientific Title

Purpose

To study whether telephone-based counseling will improve your ability to manage immunotherapy side effects.

Who is this for?

People with stage II, stage III, or stage IV (metastatic) breast cancer who have begun treatment with an immune checkpoint inhibitor within the past 3 months. You must be experiencing at least mild psychological distress. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Counseling, by phone call, weekly</li> <li class="seamTextUnorderedListItem">Handbook about managing side effects</li> <li class="seamTextUnorderedListItem">Assessment of side effects, weekly</li> <li class="seamTextUnorderedListItem">Interviews, 2 times within 4 months</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Assessment of side effects, weekly</li> <li class="seamTextUnorderedListItem">Interviews, 2 times within 4 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Immunotherapies are drugs that trigger the immune system to see, go after, and kill cancer cells.</li> <li class="seamTextUnorderedListItem">Side effects from immunotherapy are common.</li> <li class="seamTextUnorderedListItem">The ability to manage the side effects you experience from immunotherapy may reduce your distress, prevent treatment interruption, and lead to fewer visits to your doctor.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05715255' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/types/breast-cancer/treatment/immunotherapy.html#:~:text=Possible%20side%20effects%20of%20immune,reaction%20while%20getting%20these%20drugs.' target='_blank'>American Cancer Society: Immune Checkpoint Inhibitors for Breast Cancer and Their Side Effects</a> </li></ul>

No Travel Required

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT06392789

Text Messaging and Website to Improve Sleep Problems for Women with Stage I-III Breast Cancer

A Crossover Randomized Controlled Trial to Investigate the Acceptability and Efficacy of Cecebot, a Conversational Agent for Insomnia After Breast Cancer Scientific Title

Purpose

To study the ability of text message conversations with a chatbot to improve sleep problems.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who have completed treatment and have sleep problems. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Immediate Start <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sleep education text message conversations with chatbot, 2-4 times every week</li> <li class="seamTextUnorderedListItem">Sleep education website, 2-4 times every week</li> <li class="seamTextUnorderedListItem">Wear activity tracker, daily for 1.5 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Delayed Start <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No intervention for 1.5 months</li> </ul> followed by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sleep education text message conversations, 2-4 times every week</li> <li class="seamTextUnorderedListItem">Sleep education website, 2-4 times every week</li> <li class="seamTextUnorderedListItem">Wear activity tracker, daily for 1.5 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sleep disturbance is a top concern of breast cancer survivors and is associated with poor quality of life. </li> <li class="seamTextUnorderedListItem">Many breast cancer survivors also have decreased physical activity, which may also have a negative impact on sleep and quality of life. </li> <li class="seamTextUnorderedListItem">Cognitive behavioral therapy (CBT) is a type of therapy that focuses on the relationship between thoughts, feelings, and behaviors.</li> <li class="seamTextUnorderedListItem">The chatbot in this study is called Cecebot and is a personalized text message-based behavioral intervention that combines cognitive behavioral therapy and exercise with the goal of improving sleep.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06392789' target='_blank'>ClinicalTrials.gov</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: II

NCT ID: NCT05676255

Online Meditation to Reduce Anxiety and Depression After Treatment for Women with Stage I-III Breast Cancer

The SUPORT Project: Leveraging Social Connection by Including Informal Caregivers in an Internet Video Conference-based Compassion Meditation Intervention to Reduce Psychological Distress in Breast Cancer Survivors Scientific Title

Purpose

To study if meditation with or without caregivers will reduce depression and anxiety in breast cancer survivors.

Who is this for?

Women with stage I, stage II, or stage III breast cancer who completed treatment between 3 months and 5 years ago. You may still be receiving hormone therapy or trastuzumab (Herceptin®). You must have a partner or caregiver who lives with you and is willing to participate. Full eligibility criteria

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You will be randomly assigned to 1 of 3 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Meditation sessions without your partner, virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Meditation sessions with your partner, virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 3: Health Education <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health education sessions with your partner, virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Many breast cancer survivors (around 70%) experience depression and/or anxiety after finishing cancer treatments.</li> <li class="seamTextUnorderedListItem">Meditation may reduce feelings of anxiety and depression.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05676255' target='_blank'>ClinicalTrials.gov</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05612100

Studying Alopecia During Hormone Therapy in Women with Breast Cancer

Endocrine Therapy-Induced Alopecia Natural History Evaluation Among Female Breast Cancer Survivors Scientific Title

Purpose

To study the incidence, timing, duration, and severity of alopecia (hair loss) during hormone therapy.

Who is this for?

Women with stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who are receiving or planning to receive hormone therapy. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires, every 3 months for 2 years</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">While alopecia (hair loss) is a well-known side effect of many chemotherapy drugs, it has also been reported by women undergoing hormone therapy.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05612100' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/hair-loss' target='_blank'>Breastcancer.org: Alopecia/Hair Loss</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy' target='_blank'>Breastcancer.org: Hormone Therapy</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT06085313

Online Pain and Depression Support Program for Asian Women with Stage I-IV Breast Cancer

Cancer Pain Management: A Technology-Based Intervention for Asian American Breast Cancer Survivors (CAI) Scientific Title

Purpose

To study if an online pain and depression management program can support Asian women with breast cancer.

Who is this for?

Chinese, Korean, or Japanese women who were diagnosed with breast cancer in the past and are experiencing pain and depression. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: CAI (Web App Based, Individualized Coaching and Support Program for Cancer Pain) <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Personalized information and support program, online</li> <li class="seamTextUnorderedListItem">Fitbit</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: CAPA (Web App Based Information and Coaching/Support Program for Cancer Pain Management) <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General information and support program, online</li> <li class="seamTextUnorderedListItem">Fitbit</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem"> The pain and depression management program provides web-based information, coaching, and support that is culturally tailored to Asian American women with breast cancer.</li> <li class="seamTextUnorderedListItem">This trial is also available in Mandarin (simplified or traditional), Korean, and Japanese.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06085313' target='_blank'>ClinicalTrials.gov</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT06855654

Coaching Program to Reduce Stress and Promote Resilience for People with Metastatic Breast Cancer

Promoting Resilience in Stress Management for Metastatic Breast Cancer (PRISM-MBC PRISMMBC) Scientific Title

Purpose

To study the ability of the PRISM program to reduce stress and improve resilience for people with metastatic breast cancer.

Who is this for?

People with stage IV (metastatic) breast cancer who were diagnosed with metastatic disease in the last 6 months. Full eligibility criteria

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You will receive the following: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Promoting Resilience in Women with Breast Cancer (PRISM) program, virtual, 4 sessions in 1-2 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Promoting Resilience in Women with Breast Cancer (PRISM) program helps improve 4 areas of resilience: stress management, goal setting, cognitive reframing, and meaning-making.</li> <li class="seamTextUnorderedListItem">This study will compare the resilience of Black women to non-Black women.</li> <li class="seamTextUnorderedListItem">It also includes an optional family session.</li> <li class="seamTextUnorderedListItem">Each session is 30-60 minutes every 1-2 weeks.</li> <li class="seamTextUnorderedListItem">Black women with MBC have worse outcomes than white women with MBC because of social determinants of health (SDOH).</li> <li class="seamTextUnorderedListItem">Social determinants of health (SDOH) describe non-medical factors that influence your health, such as race, gender identity, education, occupation, transportation, food and health access, medication affordability, safety at home, housing, and financial stability.</li> <li class="seamTextUnorderedListItem">Reducing stress and improving resilience during MBC treatment may improve quality of life and even improve disease outcomes.</li> <li class="seamTextUnorderedListItem">This trial is also available in Spanish.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06855654' target='_blank'>ClinicalTrials.gov</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT06582615

Healthy Eating and Nutrition Counseling to Improve Cognition During Chemotherapy for Women with Stage II-III Triple Negative Breast Cancer

Food for Thought - Pilot Study of a MIND Diet Intervention in Women Undergoing Active Treatment for Triple Negative Breast Cancer (MIND-TNBC) Scientific Title

Purpose

To study if the MIND eating plan can improve memory and mental function, fatigue, sleep quality, anxiety, and depression.

Who is this for?

Women 40-65 years old with stage II or stage III triple negative (ER-, PR-, HER2-) breast cancer who are receiving (within the past 6 months) or planning to receive chemotherapy before surgery (neoadjuvant). Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MIND counseling sessions, virtual, weekly for 1 month, then every 2 weeks for 2 months</li> <li class="seamTextUnorderedListItem">Personalized eating plan, 3 months</li> <li class="seamTextUnorderedListItem">Wear a FitBit</li> <li class="seamTextUnorderedListItem">Cognitive tests, 2 times in 6 months</li> <li class="seamTextUnorderedListItem">Surveys</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General health sessions, virtual, weekly for 1 month, then every 2 weeks for 2 months</li> <li class="seamTextUnorderedListItem">Wear a FitBit</li> <li class="seamTextUnorderedListItem">Cognitive tests, 2 times in 6 months</li> <li class="seamTextUnorderedListItem">Surveys</li> </ul> followed 6 months later by: <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MIND counseling sessions, virtual, weekly for 1 month, then every 2 weeks for 2 months</li> <li class="seamTextUnorderedListItem">Personalized eating plan, 3 months</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cancer treatment can lead to cognition (ability to think) problems and low quality of life.</li> <li class="seamTextUnorderedListItem">The Neurodegenerative Delay (MIND) eating plan is high in anti-inflammatory nutrients (omega-3, carotenoids, B vitamins, etc.) and limits foods that are not healthy for the brain (butter, cheese, red meat, fried foods, sugar, etc.).</li> <li class="seamTextUnorderedListItem">The MIND eating plan may help improve brain function during cancer treatment.</li> <li class="seamTextUnorderedListItem">In this trial, you will be sent some of the main foods in the MIND eating plan.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06582615' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://health.osu.edu/wellness/exercise-and-nutrition/the-mind-diet' target='_blank'>Ohio State University: The MIND Diet and Brain Health</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05452681

Improving Quality of Life of Young Black Women After Treatment

Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors Scientific Title

Purpose

To compare how Y-AMBIENT education sessions and follow up phone calls improve quality of life after breast cancer treatment.

Who is this for?

Black or African American women ages 18 to 44 years old with stage I, stage II, or stage III breast cancer who have completed treatment with chemotherapy and/or radiation. Full eligibility criteria

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You will be randomly assigned to 1 of 2 groups: Group 1 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Y-AMBIENT education sessions, 3 times within 4 months</li> <li class="seamTextUnorderedListItem">Y-AMBIENT follow up phone calls, 3 times within 4 months</li> </ul> Group 2 <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education sessions, 3 times within 4 months</li> <li class="seamTextUnorderedListItem">Follow up phone calls, 3 times within 4 months</li> </ul> Additional Procedures <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Y-AMBIENT is telephone-based intervention with education sessions designed to improve quality of life. Session 1, titled <q>My Self, My Soul,</q> covers topics related to spiritual growth and finding meaning in illness. Session 2, titled <q>My Body,</q> covers topics related to breast changes, aches/pains, fatigue, and weight changes. Session 3, titled <q>My Mind and My Relationships,</q> covers topics related to anxiety, fear, and relationships with others.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, education sessions include a culturally-targeted cookbook and a guide to grocery shopping smart.</li> <li class="seamTextUnorderedListItem">For both groups, all sessions will take approximately one hour, and follow-up phone calls will last about 20 minutes.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05452681' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/survivorship/health-concerns/quality-of-life/#:~:text=Quality%20of%20life%20after%20treatment,even%20years%20after%20treatment%20ends.' target='_blank'>Susan G. Komen: Quality of Life After Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cdc.gov/pcd/issues/2016/16_0096.htm' target='_blank'>Centers for Disease Control and Prevention: Quality of Life of Black Breast Cancer Survivors</a> </li></ul>

No Travel Required

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05243056

Improving Quality of Life for Young African American Women with Stage I-III Breast Cancer

Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors in Treatment Scientific Title

Purpose

To study if Y-AMBIENT education sessions help African American women with breast cancer manage daily life.

Who is this for?

Black or African American women 18-44 years old with stage I, stage II, or stage III breast cancer who are receiving chemotherapy and/or radiation. Full eligibility criteria

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What's involved?
What's being studied?
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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Y-AMBIENT education sessions, by phone, 3 sessions within 4 months</li> <li class="seamTextUnorderedListItem">Phone calls discussing treatment and concerns, 3 times within 3 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Enhanced Standard of Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Phone calls discussing treatment and concerns, 3 times within 3 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Y-AMBIENT is a telephone-based intervention that includes three themed education sessions with three follow-up sessions, written materials, and videos.</li> <li class="seamTextUnorderedListItem">The Y-AMBIENT sessions are 1 hour each and may improve quality of life and other health-related outcomes.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05243056' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life' target='_blank'>Breastcancer.org: Managing Life With Cancer</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05053230

Integrative Medicine at Home Program for People With Stage I-IV Breast Cancer

Integrative Medicine for Patient-reported Outcomes, Values, and Experience (IMPROVE) Scientific Title

Purpose

To find out whether the Integrative Medicine at Home program can help reduce symptoms and improve treatment satisfaction.

Who is this for?

People with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who are currently receiving treatment. Full eligibility criteria

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What's involved?
What's being studied?
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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Integrative Medicine at Home program, 3 months</li> </ul> Group 2: Enhanced Usual Care <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Integrative medicine handout</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Integrative Medicine at Home program offers virtual (online rather than in-person) group classes focusing on mind-body practice.</li> <li class="seamTextUnorderedListItem">Mind-body practice is a health practice that combines mental focus, controlled breathing, and body movements to help relax the body and mind and reduce symptoms such as tiredness (fatigue), pain, or insomnia (sleep problems).</li> <li class="seamTextUnorderedListItem">The classes will be led by an Integrative Medicine Service (IMS) clinical therapist using Zoom video conferencing platform.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, you will be given a handout to encourage you to visit Memorial Sloan Kettering's Integrative Medicine website to access pre-recorded, on-demand meditation videos and audios.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05053230' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/diagnosis-treatment/symptom-management/integrative-medicine' target='_blank'>Memorial Sloan Kettering Cancer Center: Integrative Medicine</a> </li></ul>

No Travel Required

VISITS: No visits required

PHASE: II

NCT ID: NCT06728579

Group Therapy to Manage Joint Pain From Hormone Therapy for Women with Stage I-III HR+ Breast Cancer

Enhanced Pain Coping in Cancer (EPIC) Scientific Title

Purpose

To study if group therapy can help breast cancer survivors manage joint pain caused by aromatase inhibitors.

Who is this for?

Women with stage I, stage II, or stage III hormone receptor positive (ER+ and/or PR+) breast cancer who completed treatment at least 1 month ago. You must be receiving letrozole (Femara®), anastrozole (Arimidex®), or exemestane (Aromasin®) aromatase inhibitor and be planning to continue for at least 1 year. You must have joint pain. Full eligibility criteria

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What's involved?
What's being studied?
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You will be randomly assigned to 1 of 2 groups: Group 1: Experimental <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Group therapy that includes mindfulness and other coping strategies, virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Practice learned skills, at home, 15 minutes every day for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> Group 2: Control <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Group therapy that includes discussion on chronic pain and cancer survivorship, virtual, weekly for 2 months</li> <li class="seamTextUnorderedListItem">Write in a journal, at home, 15 minutes every day for 2 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Joint pain is common in people taking aromatase inhibitors. This pain can make some people decide to stop taking their medication. </li> <li class="seamTextUnorderedListItem">This study will look at the effects of 2 different types of group therapy on your cancer-related symptoms (such as pain, fatigue, and anxiety), your ability to continue taking aromatase inhibitors on a regular schedule, and your quality of life.</li> <li class="seamTextUnorderedListItem">All sessions in Group 1 and Group 2 are 2 hours each.</li></ul>
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06728579' target='_blank'>ClinicalTrials.gov</a> </li></ul>