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In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. Use the contact information in our trial listings to call or email the research site for information about a trial's status.
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(Last updated: July 24, 2021)
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Targeted Therapy: Anti-HER2 Therapy
Targeted Therapy: CDK Inhibitors
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AKT
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1
NEAREST SITE: 3 miles
University of California, San Francisco
San Francisco,CA
VISITS: Number of visits unavailable, up to 2 years
PHASE: II
NCT ID: NCT03094052
Diarrhea Prevention for People With HER2+ Breast Cancer Receiving Neratinib Alone or With Herceptin
An Open Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early Stage HER2+ Breast Cancer Treated With Adjuvant Trastuzumab and Neratinib Followed by Neratinib Monotherapy, and Intensive Anti-diarrhea Prophylaxis Scientific Title
Purpose
To study whether taking anti-diarrhea medication can help prevent diarrhea in people being treated with neratinib (Nerlynx®) alone or in combination with trastuzumab (Herceptin®).
Who is this for?
People with stage II or stage III, HER2 positive (HER2+) breast cancer who have finished chemotherapy and radiation therapy and who are still receiving adjuvant trastuzumab (Herceptin®) or are within 1 year of finishing trastuzumab (Herceptin®).
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Trastuzumab (Herceptin®), by IV, as indicated by your doctor</li> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®), by mouth, daily, up to 2 years</li> <li class="seamTextUnorderedListItem">Loperamide, by mouth, daily for 6 weeks, then as needed</li> <li class="seamTextUnorderedListItem">Crofelemer (Mytesi®), by mouth, daily for 6 weeks, then as needed</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two approved HER2-targeted drugs used in this trial are trastuzumab (Herceptin®) and neratinib (Nerlynx®)</li> <li class="seamTextUnorderedListItem">Neratinib (Nerlynx®) is known to cause diarrhea.</li> <li class="seamTextUnorderedListItem">Crofelemer (Mytesi®) is a medicine used to prevent diarrhea in people being treated for HIV/AIDS. </li> <li class="seamTextUnorderedListItem">Loperamide (Immodium) is an over-the-counter medication used to prevent and treat diarrhea.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03094052' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.fulyzaq.com/' target='_blank'>Drug Company Information Page: Crofelemer (Mytesi)</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/web-exclusives/fda-accepts-neratinib-nda-for-her2positive-breast-cancer' target='_blank'>OncLive: Neratinib</a> </li></ul>
2
NEAREST SITE: 3 miles
University of California San Francisco
San Francisco,CA
VISITS: 1 visit
PHASE: NA
NCT ID: NCT04876378
Imaging to See How Aromatase Inhibitors Affects Joint Health in Stage I-III Breast Cancer
Impact of Breast Cancer Treatment on Joint Health, Cartilage Composition, and Bone Structure in the Knee and Hand Scientific Title
Purpose
To study how aromatase inhibitors (anti-estrogen therapy) affect hand and knee joints.
Who is this for?
People, 70 or younger, diagnosed with stage I, stage II, or stage III hormone-positive (ER+ and/or PR+) breast cancer who have been taking an aromatase inhibitor for at least one year. You may also enroll in this trial if you are postmenopausal and have never been diagnosed with breast cancer.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires, one time</li> <li class="seamTextUnorderedListItem">MRI, lasting about 1 hour, one time</li> <li class="seamTextUnorderedListItem">HR-pQCT (High-Resolution Peripheral Quantitative Computed Tomography), lasting about one hour, one time</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aromatase inhibitors are a type of anti-estrogen therapy commonly used in people with hormone-positive breast cancer.</li> <li class="seamTextUnorderedListItem">The approved aromatase inhibitors are anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®).</li> <li class="seamTextUnorderedListItem">Joint pain is a commonly reported side effect of taking an aromatase inhibitor.</li> <li class="seamTextUnorderedListItem">This trial will use two different imaging techniques to study knee and hand joints.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04876378' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li></ul>
3
NEAREST SITE: 9 miles
Alta Bates Summit Medical Center - Summit Campus
Oakland,CA
VISITS: Coincides with surgery
PHASE: III
NCT ID: NCT03927027
Preventing Lymphedema in Women Having Breast Surgery and a Lymph Node Dissection
ARM: Axillary Reverse Mapping - A Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection With and Without Axillary Reverse Mapping Scientific Title
Purpose
To see if using a surgical technique called Axillary Reverse Mapping during surgery to remove lymph nodes from your underarm area (axillary lymph node dissection) prevents lymphedema.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who have not yet had surgery.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Isosulfan Blue, by injection, during surgery</li> <li class="seamTextUnorderedListItem">Axillary Lymph Node Dissection (ALND)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Isosulfan Blue, by injection, during surgery</li> <li class="seamTextUnorderedListItem">Axillary Lymph Node Dissection (ALND)</li> <li class="seamTextUnorderedListItem">Axillary Reverse Mapping (ARM), during ALND</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that may develop as a side effect of some breast cancer surgeries. </li> <li class="seamTextUnorderedListItem">Lymphedema happens when there is a blockage in your lymphatic system (a part of your immune system) that stops the lymph fluid from draining well. The fluid buildup causes the abnormal swelling. </li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND). This surgery may cause a blockage in your lymphatic system.</li> <li class="seamTextUnorderedListItem">During your ALND, a blue dye will be used to see your lymph nodes and the lymphatic channels that drain your arm. </li> <li class="seamTextUnorderedListItem">Axillary Reverse Mapping (ARM) is when your surgeon tries to avoid disrupting the lymph nodes and lymphatic channels that drain your arm. This may prevent you from developing lymphedema.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03927027' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayoclinic.org/diseases-conditions/lymphedema/symptoms-causes/syc-20374682' target='_blank'>Mayo Clinic: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq' target='_blank'>NCI: Lymphedema (PDQ®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/uploadedFiles/_Komen/Content/About_Breast_Cancer/Tools_and_Resources/Fact_Sheets_and_Breast_Self_Awareness_Cards/AxillaryLymphNodes.pdf' target='_blank'>Susan G. Komen: Axillary Lymph Nodes</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ons.org/node/1531?display=pepnavigator&sort_by=created&items_per_page=50' target='_blank'>Oncology Nursing Society: Axillary Reverse Mapping (ARM)</a> </li><li class='seamTextUnorderedListItem'><a href='https://breast360.org/topic/2017/01/01/axillary-reverse-mapping/' target='_blank'>Breast360.org: Axillary Reverse Mapping</a> </li></ul>
4
NEAREST SITE: 22 miles
Contra Costa Regional Medical Center
Martinez,CA
VISITS: Number of visits unavailable
PHASE: III
NCT ID: NCT03418961
Carvedilol to Prevent Heart Problems in Patients with Metastatic HER2+ Breast Cancer
Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients With Metastatic HER-2+ Breast Cancer, Phase III Scientific Title
Purpose
To investigate whether giving people with HER2+ breast cancer a beta-blocker can help prevent heart problems caused by cancer treatments.
Who is this for?
People with HER2 positive metastatic (stage IV) breast cancer who are starting or continuing a trastuzumab-based anitHER2 therapy.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Carvedilol, by mouth, daily for up to 2 years</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No intervention</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: If you are already taking taking a beta blocker, ARB, or ACE inhibitor</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Observation for up to 2 years</li></ul>
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<p class="seamTextPara"> The beta-blocker being used in this study is carvedilol. It is used to treat heart failure and high blood pressure.</p>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03418961' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/side_effects/heart_probs' target='_blank'>Breastcancer.org: Heart Problems</a> </li></ul>
5
NEAREST SITE: 336 miles
University of California at Los Angeles
Los Angeles,CA
VISITS: 1 visit
PHASE: NA
NCT ID: NCT04297020
Studying the Effects of Anti-Estrogen Therapy on the Brain of Women with Stage I-III Breast Cancer
Brain Health in Breast Cancer Survivors: Interaction of Menopause and Endocrine Therapy Scientific Title
Purpose
To see if anti-estrogen therapy affects brain health.
Who is this for?
Women between the ages of 35 and 65 who are currently taking anti-estrogen therapy for stage I, stage II, or stage III breast cancer and who did not receive chemotherapy. This trial is also enrolling women who have never been diagnosed with breast cancer.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 Brain fMRI (functional MRI)</li> <li class="seamTextUnorderedListItem">Cognitive testing</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This trial will use an advanced brain MRI technique called functional MRI (fMRI).</li> <li class="seamTextUnorderedListItem">fMRI measures changes in blood flow that happen during mental activity. </li> <li class="seamTextUnorderedListItem">Research suggests that the cognitive issues experienced by some people who receive treatment for breast cancer--also called <q>chemo brain</q>--may actually be caused by anti-estrogen therapy and not chemotherapy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04297020' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medscape.com/viewarticle/932091' target='_blank'>MedScape: In Breast Cancer, Is Chemobrain Really Endocrine Brain?</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Functional_magnetic_resonance_imaging' target='_blank'>Wikipedia: Functional MRI</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.radiologyinfo.org/en/info.cfm?pg=fmribrain' target='_blank'>RadiologyInfo.org: fMRI</a> </li></ul>
6
NEAREST SITE: 386 miles
Loma Linda Medical Center
Loma Linda,CA
VISITS: 2 visits weekly, for 6 weeks
PHASE: NA
NCT ID: NCT03272919
Physical Therapy to Prevent Peripheral Neuropathy in Women with Early-Stage Breast Cancer
Chemotherapy Induced Peripheral Neuropathy (CIPN): A Pilot Study of Intraneural Facilitation for Managing Chemotherapy-Induced Peripheral Neuropathy Scientific Title
Purpose
To study whether a new physical therapy technique called intraneural facilitation can restore blood flow to damaged nerves and reduce the risk of peripheral neuropathy.
Who is this for?
Women who are newly diagnosed with early stage (stage I-III) breast cancer. You must also be planning to receive platinum- and/or taxane-based chemotherapy.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Intraneural facilitation (physical therapy), twice a week, for 6 weeks</li> <li class="seamTextUnorderedListItem">3 assessments (ultrasound, surveys and questionnaires) over 4.5 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care muscle stretching and strengthening, twice a week, for 6 weeks</li> <li class="seamTextUnorderedListItem">3 assessments (ultrasound, surveys and questionnaires) over 4.5 months</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You must be planning to receive platinum- and/or taxane-based chemotherapy. This includes carboplatin/Paraplatin® or cisplatin/Platinol® and/or docetaxel/Taxotere® or paclitaxel/Taxol®. </li> <li class="seamTextUnorderedListItem">Intraneural facilitation (INF) is a technique that helps improve blood flow to the nerves by widening tiny openings in nearby arteries. The improved blood flow may stimulate healing and reduce or stop nerve pain.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03272919' target='_blank'>ClinicalTrials.gov</a> </li></ul>
7
NEAREST SITE: 602 miles
Huntsman Cancer Institute
Salt Lake City,UT
VISITS: 2 visits over 1 week
PHASE: NA
NCT ID: NCT02317783
Using Brain Imaging to Study the Effect of Chemotherapy on the Brain
Amyloid Plaque Deposition in Chemotherapy-Induced Cognitive Impairment Scientific Title
Purpose
To use PET scans to study how chemotherapy affects the brain.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who received chemotherapy after surgery within the last three years.
Full eligibility criteria
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<p class="seamTextPara"> You will receive 2 FDG-PET scans using flutemetamol over a week</p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Many cancer patients have thinking and memory problems due to cancer or its treatments. The reasons for this <q>mental fog,</q> referred to as chemo brain, are not always known.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02317783' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02317783?term=NCT02317783&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/chemotherapyeffects/chemo-brain' target='_blank'>Cancer.org: Chemo Brain</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm372261.htm' target='_blank'>FDA.gov: Imaging Drug, Flutemetamol</a> </li></ul>
8
NEAREST SITE: 1500 miles
University of Kansas Medical Center
Kansas City,KS
VISITS: Daily visits for 1 month
PHASE: NA
NCT ID: NCT02958774
Hypofractionated Radiation To Treat Regional Lymph Nodes to Reduce Lymphedema Risk
Hypofractionated Radiation Therapy for Patients With Breast Cancer Receiving Regional Nodal Irradiation Scientific Title
Purpose
To learn whether hypofractionated radiation therapy is less likely to cause lymphedema than conventional radiation therapy.
Who is this for?
Women with stage II or stage III breast cancer that has spread to the lymph nodes (node positive) who will be treated with radiation after breast cancer surgery.
Full eligibility criteria
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<p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy, daily, for 1 month</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a swelling of the soft tissues in the arm and hand caused by a build-up of lymph fluid. </li> <li class="seamTextUnorderedListItem">Radiation therapy to the lymph nodes can result in scar tissue that blocks the lymph flow, increasing risk for lymphedema. </li> <li class="seamTextUnorderedListItem">Hypofractionated radiation therapy is a type of radiation therapy that is given at a higher dose over a shorter period of time than standard radiation therapy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02958774' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hypofractionated-radiation-therapy' target='_blank'>NCI Dictionary of Cancer Terms: Hypofractionated radiation therapy</a> </li></ul>
9
NEAREST SITE: 1615 miles
Mayo Clinic in Rochester
Rochester,MN
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT03428581
Two Surgical Techniques to Prevent Lymphedema in Women Having a Lymph Node Dissection
Preventing Lymphedema in Patients Undergoing Axillary Lymph Node Dissection Via Axillary Reverse Mapping and Lympho-venous Bypass Scientific Title
Purpose
To see if using two surgical techniques during surgery to remove lymph nodes from your underarm area (axillary lymph node dissection) prevents lymphedema.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who will be having an axillary lymph node dissection (ALND).
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups and receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND)</li> <li class="seamTextUnorderedListItem">Axillary reverse mapping (ARM), during the ALND</li> <li class="seamTextUnorderedListItem">Lymphovenous bypass, during the ALND</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is abnormal swelling in the arm, hand, breast, or torso that may develop as a side effect of some breast cancer surgeries.</li> <li class="seamTextUnorderedListItem">Lymphedema happens when there is a blockage in your lymphatic system (a part of your immune system) that stops the lymph fluid from draining well. The fluid buildup causes the abnormal swelling.</li> <li class="seamTextUnorderedListItem">The surgery that removes lymph nodes from your underarm area is called an axillary lymph node dissection (ALND).</li> <li class="seamTextUnorderedListItem">Axillary Reverse Mapping (ARM) is when a dye is injected into your arm so that your surgeon can see and try to avoid disrupting the lymph nodes and lymphatic channels that drain your arm. </li> <li class="seamTextUnorderedListItem">Lymphovenous bypass is when your surgeon connects some of your lymphatic channels directly into tiny veins in your arm.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03428581' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayo.edu/research/clinical-trials/cls-20359609' target='_blank'>Mayo Clinic: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/surgery/lymph_node_removal/axillary_dissection' target='_blank'>Breastcancer.org: Axillary Lymph Node Dissection (ALND)</a> </li><li class='seamTextUnorderedListItem'><a href='https://breast360.org/topic/2017/01/01/axillary-reverse-mapping/' target='_blank'>Breast360.org: Axillary Reverse Mapping (ARM)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/about-your-lymphovenous-bypass-lvb-surgery-lymphedema' target='_blank'>Memorial Sloan Kettering Cancer Center: About Your Lymphovenous Bypass (LVB) Surgery for Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/plastic_reconstructive_surgery/services-appts/lymphedema.html' target='_blank'>Johns Hopkins Medicine: Surgical Treatment of Lymphedema</a> </li></ul>
10
NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX
VISITS: 1 visit
PHASE: NA
NCT ID: NCT03012399
Effects of Hypnosis During Breast Cancer Surgery
Biobehavioral Effects of Hypnosis During Breast Cancer Surgery Scientific Title
Purpose
To study a relaxation method called hypnosedation.
Who is this for?
Women with DCIS or stage I breast cancer who have not yet had breast surgery.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnosedation performed by a hypnotherapist, beginning right before surgery and continuing through until your surgery ends</li> <li class="seamTextUnorderedListItem">Conscious sedation during surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Empathetic conversation with a hypnotherapist right before surgery</li> <li class="seamTextUnorderedListItem">General anesthesia during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Using hypnosedation before and during breast cancer surgery may allow patients to avoid having general anesthesia.</li> <li class="seamTextUnorderedListItem">Hypnosedation is administered by a hypnotherapist, a mind-body specialist who uses words and images to help you relax during surgery.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03012399' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://abcnews.go.com/Health/Healthday/story?id=4508455&page=1' target='_blank'>ABC News: Hypnosis Article</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/comp_med/types/hypnosis' target='_blank'>Breastcancer.org: Hypnosis</a> </li></ul>
11
NEAREST SITE: 1643 miles
Houston Methodist Cancer Center
Houston,TX
VISITS: 4 visits, over 6 months
PHASE: II
NCT ID: NCT01984138
Hormone Therapy or Lotion Inside the Vagina for Women with Stage I-III ER+ Breast Cancer Taking an Aromatase Inhibitor (Anti-Estrogen Therapy)
REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy Scientific Title
Purpose
To compare the safety and effects of using vaginal estrogen (Estring) or a vaginal moisturizer (Replens) to treat vaginal dryness, pain during intercourse, and other vaginal side effects of taking an aromatase inhibitor.
Who is this for?
Postmenopausal women with stage I, stage II, or stage III estrogen-receptor positive (ER+) breast cancer experiencing vaginal dryness, pain during intercourse, or 3 or more urinary tract infections a year since starting an aromatase inhibitor.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Estring vaginal ring, inserted into the vagina, every 3 months, for 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2 </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Replens vaginal lotion, applied inside the vagina, 3 times a week, for 6 months</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aromatase inhibitors are a type of anti-estrogen therapy commonly used for stage I-IV hormone-positive (ER+ and/or PR+) breast cancer. </li> <li class="seamTextUnorderedListItem">The approved aromatase inhibitors are anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®).</li> <li class="seamTextUnorderedListItem">The side effects of taking an aromatase inhibitor may include vaginal dryness, vaginal itching, pain during intercourse, and urinary tract infections. </li> <li class="seamTextUnorderedListItem">Replens is a moisturizer that is applied inside the vagina. It does not contain any hormones.</li> <li class="seamTextUnorderedListItem">Estring is a ring that is placed inside the vagina and releases a low dose of estrogen.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01984138' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.houstonmethodist.org/1285_houstonmethodist/2847_ourresearch/2922_research_clinicaltrials/2923_research_searchclinicaltrials/clinicaltrialdetailnew/?Id=Pro00017710' target='_blank'>Houston Methodist Medical Center: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.estring.com/vaginal-atrophy-relief#estring' target='_blank'>Pfizer Drug Information Page: Estring (Vaginal Estrogen)</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.replens.com/Products/Replens-Long-Lasting-Moisturizer/FAQS.aspx' target='_blank'>Replens Drug Information Page: Replens (Vaginal Moisturizer)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/tips/menopausal/treat/vaginal-changes' target='_blank'>Breastcancer.org: Menopause Symptoms and Vaginal Changes</a> </li></ul>
12
NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX
VISITS: 10-12 visits over 8 weeks
PHASE: II
NCT ID: NCT02754752
Acupuncture for Relieving Severe Post-Mastectomy Pain
Randomized-Controlled Trial of Acupuncture for Post-Mastectomy Pain Syndrome Scientific Title
Purpose
This study is investigating whether electro-acupuncture can help reduce pain women feel after their mastectomy.
Who is this for?
Women who had a mastectomy at least 4 months ago. You must have had persistent pain in your chest area for at least 3 months and have seen your oncologist within the last 6 months.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Acupuncture on specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Acupuncture on non-specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Wait-List</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No acupuncture</li> <li class="seamTextUnorderedListItem">After 4 weeks, optional participation in up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Electro-acupuncture is a two-step process. First, hair-thin needles are put into specific points in your body. Then, a mild electrical current is applied to the needles at a level that is comfortable to you.</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02754752' target='_blank'>ClinicalTrials.gov</a> </li></ul>
13
NEAREST SITE: 1655 miles
University of Iowa Hospitals and Clinics
Iowa City,IA
VISITS: Weekly visits for 3 months
PHASE: II
NCT ID: NCT03642990
Vitamin B3 to Reduce Paclitaxel-Related Peripheral Neuropathy in Metastatic Breast Cancer
Nicotinamide Riboside (NR) in Paclitaxel-induced Peripheral Neuropathy Scientific Title
Purpose
To determine whether nicotinamide riboside (Niagen®) prevents the progression of peripheral neuropathy.
Who is this for?
People with stage IV metastatic breast cancer that is being treated with paclitaxel (Taxol®).
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nicotinamide Riboside (Niagen®), by mouth, twice daily for 3 months</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nicotinamide riboside (NR) is a vitamin B3 supplement. </li> <li class="seamTextUnorderedListItem">Studies suggest it may help prevent or treat nerve pain. </li> <li class="seamTextUnorderedListItem">Neuropathy--pain or numbness in the hands and feet--is a type of nerve pain. </li> <li class="seamTextUnorderedListItem">It is a common side effect of certain types of chemotherapy.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03642990' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/neuropathy' target='_blank'>Breastcancer.org: Neuropathy</a> </li><li class='seamTextUnorderedListItem'><a href='https://medcom.uiowa.edu/theloop/news/nicotinamide-riboside-vitamin-b3-prevents-nerve-pain-caused-by-cancer-drugs' target='_blank'>University of Iowa: Nicotinamide riboside (vitamin B3) prevents nerve pain caused by cancer drugs</a> </li></ul>
14
NEAREST SITE: 1728 miles
Mercy David C. Pratt Cancer Center
Saint Louis,MO
VISITS: Periodic visits for 3 years; then 1-3 visits per week for 1 month if needed
PHASE: NA
NCT ID: NCT03292198
L-Dex to Identify Breast Cancer-Related Lymphedema
Treatment Indications for Breast Cancer-related Subclinical Lymphedema Identified Through a Bioimpedance Surveillance Model Scientific Title
Purpose
To evaluate whether routine screening with L-Dex to detect lymphedema early improves patient outcomes.
Who is this for?
Women whose breast cancer surgery will include a sentinel lymph node biopsy or axillary lymph node dissection.
Full eligibility criteria
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<p class="seamTextPara"> You will receive periodic screening with L-dex for 3 years following surgery. If you develop lymphedema, you will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Wear compression sleeves and gloves, daily, for 1 month</li> <li class="seamTextUnorderedListItem">L-dex measurement, weekly </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Manual Lymphatic Drainage, 3 times per week, for 1 month</li> <li class="seamTextUnorderedListItem">Wear compression sleeves and gloves, daily, for 1 month</li> <li class="seamTextUnorderedListItem">L-dex measurement, weekly</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a common side effect after breast cancer surgery. </li> <li class="seamTextUnorderedListItem">It causes pain and swelling in the hands and arms. </li> <li class="seamTextUnorderedListItem">L-Dex is a portable system that uses a small electrical current to detect the build up of lymphatic fluid before it begins to cause side effects. </li> <li class="seamTextUnorderedListItem">Patients who develop lymphedema will be randomized to receive one of two treatment plans for breast cancer-related lymphedema.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03292198' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nice.org.uk/advice/mib111/chapter/The-technology' target='_blank'>National Institute for Health and Care Excellence UK: L-Dex</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li></ul>
15
NEAREST SITE: 1739 miles
Washington University School of Medicine
Saint Louis,MO
VISITS: At least 7 visits over 3 years
PHASE: II
NCT ID: NCT03862131
PROactive Evaluation to Reduce Treatment-Related Heart Problems (PROACT)
PROactive Evaluation of Function to Avoid CardioToxicity Scientific Title
Purpose
To look at whether MyoStrain® measurements are as good as or better than traditional MRI measurements for predicting and reducing a patient's risk of developing treatment-related heart problems.
Who is this for?
People with stage I, stage II, stage III, or stage IV (metastatic) breast cancer scheduled to start cancer therapy.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cardiac MRI at 1 month, 3 months, 6 months, 1 year, 2 years, and 3 years after the baseline visit</li> <li class="seamTextUnorderedListItem">MyoStrain® measurements</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cardiac MRI at 1 month, 3 months, 6 months, 1 year, 2 years, and 3 years after the baseline visit</li> <li class="seamTextUnorderedListItem">Standard of care MRI measurements (LVEF and LVEDV/LVESV)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MyoStrain® analyzes data collected from MRI heart scans to assess a patient's risk of developing heart problems.</li> <li class="seamTextUnorderedListItem">This imaging trial will compare if measurements taken by MyoStrain® are better able to predict who will develop heart problems from cancer therapies than the traditional measurements taken by MRI.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03862131' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.myocardialsolutions.com/' target='_blank'>Myocardial Solutions Product Information Page: MyoStrain®</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nccn.org/patients/resources/life_with_cancer/managing_symptoms/cardiac_toxicity.aspx' target='_blank'>National Comprehensive Cancer Network: Cardiac Toxicity</a> </li></ul>
16
NEAREST SITE: 1857 miles
University of Chicago
Chicago,IL
VISITS: 1 visit
PHASE: NA
NCT ID: NCT03238976
Nature Sounds to Reduce Pain and Anxiety During a Breast Core Needle Biopsy
Nature Sounds as a Pain and Anxiety Reducing Strategy in Patients Undergoing Breast Core Biopsy: A Randomized Study Scientific Title
Purpose
To investigate the effects (good and bad) playing continuous nature sounds during a core needle biopsy has on a patient's pain and anxiety.
Who is this for?
Women scheduled to have a breast core needle biopsy.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Receive continuous nature sounds during core needle biopsy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Receive supportive dialogue during core needle biopsy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A core needle biopsy is a procedure that removes a small amount of suspicious tissue from the breast with a needle.</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03238976' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/BreastCancer/CoreNeedleBiopsy.html' target='_blank'>Susan G. Komen: Core Needle Biopsy</a> </li></ul>
17
NEAREST SITE: 2010 miles
University of Alabama at Birmingham Hospitals and Affiliated Clinics
Birmingham,AL
VISITS: 1 visit that coincides with surgery
PHASE: NA
NCT ID: NCT04019834
Using a PECS Block During a Mastectomy to Reduce Pain After Surgery in Women
Preoperative Regional Nerve Block to Decrease Acute and Chronic Post-Operative Pain and Narcotic Use Following Mastectomy Scientific Title
Purpose
To see if a pectoral nerve block given during a mastectomy helps reduce pain after surgery.
Who is this for?
Women scheduled to receive a mastectomy.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: PECS Block</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pectoral Nerve Block (PECS), by injection, during surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for Pectoral Nerve Block, by injection, during surgery</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A pectoral nerve block (PECS) is a procedure used during surgery.</li> <li class="seamTextUnorderedListItem">During your surgery, a local anesthesia will be injected into the muscles of your chest and arm pit. This injection will numb the nerves in the area where the surgery will be performed, and this may decrease the pain you feel after your surgery is over.</li> <li class="seamTextUnorderedListItem">Bupivacaine hydrochloride (Marcaine) is the local anesthesia used in this trial.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04019834' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Bupivacaine' target='_blank'>Wikipedia: Bupivacaine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/books/NBK547691/' target='_blank'>Journal Article: Pectoralis Nerve Block</a> </li></ul>
18
NEAREST SITE: 2108 miles
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Wexner Medical Center
Columbus,OH
VISITS: At least 2 visits
PHASE: NA
NCT ID: NCT02415387
Typhoid Vaccine to Study Immune Response in Patients Who Received Chemotherapy
The IMPACT Study: Inflammatory Responses, Mood and Physical Fitness After Cancer Treatment Scientific Title
Purpose
To investigate how women who have completed treatment for early-stage breast cancer respond to a typhoid vaccine by measuring their cardiorespiratory fitness, natural inflammatory reaction, and behavioral responses such as depression, fatigue, pain, and problems with thinking and reasoning.
Who is this for?
Women who are postmenopausal and have received chemotherapy as part of breast cancer treatment.
Full eligibility criteria
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<p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Typhoid vaccine, by injection, on first visit</li> <li class="seamTextUnorderedListItem">followed by placebo, by injection, on second visit (2 weeks to 1 month later)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo, by injection, on first visit</li> <li class="seamTextUnorderedListItem">followed by typhoid vaccine, by injection, on second visit (2 weeks to 1 month later)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy can weaken the body's immune system. </li> <li class="seamTextUnorderedListItem">Physical fitness may protect the body from the effects that chemotherapy has on the immune system as well as reduce other health problems. </li> <li class="seamTextUnorderedListItem">Giving patients a typhoid vaccine allows researchers to study their immune response.</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02415387' target='_blank'>ClinicalTrials.gov</a> </li></ul>
19
NEAREST SITE: 2258 miles
University of Pittsburgh
Pittsburgh,PA
VISITS: Visits 3 times a week over 6 months
PHASE: NA
NCT ID: NCT02793921
An Exercise Program to Improve Thinking and Memory in Women on an Aromatase Inhibitor
Influence of Exercise on Neurocognitive Function in Breast Cancer Scientific Title
Purpose
To see if taking part in a supervised aerobic exercise program during the first 6 months on an aromatase inhibitor will help improve thinking, memory, learning, attention and other brain functions.
Who is this for?
Women who have had surgery for stage I, stage II, or stage III breast cancer and are planning to start on a type of anti-estrogen drug called an aromatase inhibitor.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A supervised aerobic exercise program, 3 times a week, during the first 6-months of aromatase inhibitor therapy</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Control</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Normal physical activity (neither limited or withheld), during the first 6-months of aromatase inhibitor therapy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Problems with thinking, memory and other brain functions are a common side effect of the aromatase inhibitors. </li> <li class="seamTextUnorderedListItem">The aromatase inhibitors are anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®). </li> <li class="seamTextUnorderedListItem">All three are used to treat hormone receptor positive (ER+ and/or PR+) tumors in postmenopausal women.</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02793921' target='_blank'>ClinicalTrials.gov</a> </li></ul>
20
NEAREST SITE: 2352 miles
University of Rochester
Rochester,NY
VISITS: 5 visits over 3-5 months
PHASE: NA
NCT ID: NCT03137095
Memory Problems During Chemotherapy in Patients with Stage I-III Breast Cancer
Longitudinal Pilot Mechanistic Study of the Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients and Non-Cancer Control Participants Scientific Title
Purpose
To see if and how your cognitive functioning skills, like memory and concentration, change as you receive chemotherapy.
Who is this for?
Women who have been recently diagnosed with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy.
Full eligibility criteria
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<p class="seamTextPara"> You will undergo the following over 3-5 months: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3 computerized and paper-based cognitive tests during chemotherapy and 1 month after completion of chemotherapy</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Researchers will give you cognitive tests during your chemotherapy treatment and one month after you have completed treatment.</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03137095' target='_blank'>ClinicalTrials.gov</a> </li></ul>
21
NEAREST SITE: 2352 miles
University of Rochester NCORP Research Base
Rochester,NY
VISITS: Number of visits unavailable
PHASE: III
NCT ID: NCT03367572
Combinations of Antiemetics for Reducing Chemotherapy-Induced Nausea and Vomiting
Treatment of Refractory Nausea Scientific Title
Purpose
To study which combination of antiemetic drugs is most effective in reducing nausea and vomiting that often occur in patients receiving chemotherapy.
Who is this for?
Women diagnosed with breast cancer but who have not yet started chemotherapy.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Netupitant/palonosetron hydrochloride, by mouth, within 1 hour prior to receiving chemotherapy, on day 1 </li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, within 30 minutes prior to chemotherapy, days 1-4 </li> <li class="seamTextUnorderedListItem">Placebo, by mouth, every 8 hours with chemotherapy, days 1-4 </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Netupitant/palonosetron hydrochloride, by mouth, within 1 hour prior to receiving chemotherapy, on day 1 </li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, within 30 minutes prior to chemotherapy, days 1-4 </li> <li class="seamTextUnorderedListItem">Prochlorperazine and placebo, by mouth, every 8 hours with chemotherapy, days 1-4 </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Netupitant/palonosetron hydrochloride, by mouth, within 1 hour prior to receiving chemotherapy, on day 1 </li> <li class="seamTextUnorderedListItem">Dexamethasone, by mouth, within 30 minutes prior to chemotherapy, days 1-4 </li> <li class="seamTextUnorderedListItem">Olanzapine and placebo, by mouth, every 8 hours with chemotherapy, days 1-4</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The antiemetic drugs being used in this study are netupitant/palonsetron hydrochloride (Akynzeo), dexamethasone (Decadrone), prochlorperazine, and olanzapine (Zyprexa).</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03367572' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/updated-asco-guidelines-on-antiemetics' target='_blank'>ASCO: Guidelines to treat nausea and vomiting</a> </li></ul>
22
NEAREST SITE: 2383 miles
Mayo Clinic in Florida
Jacksonville,FL
VISITS: Number of visits unavailable, over 4 months
PHASE: II
NCT ID: NCT04249622
Rifaximin for Diarrhea in People Planning to Receive Pertuzumab for Stage I-III, HER2+ Breast Cancer
Phase II Trial of Rifaximin in Patients With Early Stage HER2 Positive Breast Cancer With Gastrointestinal Toxicities Related to Pertuzumab-Based Therapy Scientific Title
Purpose
To study if rifaximin lessens diarrhea and other gastrointestinal side effects in people receiving pertuzumab (Perjeta®).
Who is this for?
People with stage I, stage II, or stage III HER2 positive (HER2+) breast cancer who will be receiving pertuzumab (Perjeta®) along with chemotherapy.
Full eligibility criteria
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<p class="seamTextPara"> If you experience diarrhea or other stomach-based side effects caused by receiving pertuzumab (Perjeta®), you will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Rifaximin, by mouth, twice a day (or five days in a row), every 3 weeks, for 4 months</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pertuzumab (Perjeta®) is a HER2-targeted therapy used to treat HER2 positive (HER2+) breast cancer. One of its common side effects is diarrhea. </li> <li class="seamTextUnorderedListItem">Rifaximin is an antibiotic commonly used to treat traveler's diarrhea, but its use in this trial is considered experimental.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04249622' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/perjeta' target='_blank'>Breastcancer.org: Pertuzumab (Perjeta®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Rifaximin' target='_blank'>Wikipedia: Rifaximin</a> </li></ul>
23
NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center
Bethesda,MD
VISITS: Number of visits unavailable
PHASE: I
NCT ID: NCT04054752
Immunotherapy to Boost the Immune System of People 60 or Older Who Have Finished Breast Cancer Treatment
A Phase 1/1b Study of Enhancement of Immune Reconstitution and Vaccine Responses With Administration of Recombinant Human IL-7-hyFc (NT-I7) in Older Subjects Following Chemotherapy Scientific Title
Purpose
To see if the immunotherapy NT-I7 boosts the immune system enough for people who have finished treatment for breast cancer to have typical reactions to common vaccines.
Who is this for?
People, 60 or older, who have completed treatment for breast cancer within the last six months.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NT-I7</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NT-I7</li> <li class="seamTextUnorderedListItem">Vaccinations for a variety of illnesses, by injection, 4 times, over 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Treatments for breast cancer can weaken the immune system of older adults. </li> <li class="seamTextUnorderedListItem">A weakened immune system means that common vaccines do not work as well.</li> <li class="seamTextUnorderedListItem">NT-17 is an experimental immunotherapy. Researchers believe it will boost the immune system so that older adults who have finished treatment for breast cancer can have typical immune responses to vaccines.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people who have completed treatment for other types of cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04054752' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/low-blood-counts/infections/why-people-with-cancer-are-at-risk.html' target='_blank'>American Cancer Society: Why People with Cancer Are More Likely to Get Infections</a> </li><li class='seamTextUnorderedListItem'><a href='http://neoimmunetech.com/technology/page2020_ver3.html' target='_blank'>NeoImmuneTech Drug Information Page: NT-I7</a> </li></ul>
24
NEAREST SITE: 2504 miles
Albert Einstein Medical Center Montgomery
East Norriton,PA
VISITS: 2 visits, over 3 months
PHASE: NA
NCT ID: NCT04554316
Steri Strips to Improve Cosmetic Outcomes and Reduce Infections from Biopsies, Lumpectomies and Mastectomies
Aesthetic Effect of Steri-Strip Orientation on Healing and Scar Appearance in Breast Surgery Scientific Title
Purpose
To study whether using Steri Strips on a surgical incision helps reduce infections and improves cosmetic outcomes.
Who is this for?
People receiving a biopsy, lumpectomy or mastectomy.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Steri Strips placed over the surgical incision at the time of procedure</li> <li class="seamTextUnorderedListItem">Rating of scar appearance, at 1 month and 3 months</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Steri Strips are adhesive bandages sometimes used when people receive stitches.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04554316' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healthline.com/health/steri-strips' target='_blank'>Healthline.com: Steri Strips</a> </li></ul>
25
NEAREST SITE: 2519 miles
Kaitlyn Kennard
Philadelphia,PA
VISITS: Coincides with surgery
PHASE: NA
NCT ID: NCT04086394
Using a PECS Block During Lumpectomy to Reduce Pain After Surgery
Use of PECS Block in Partial Mastectomy for Postoperative Pain Control and Mitigation of Narcotic Use- A Randomized Control Trial Scientific Title
Purpose
To see if a pectoral nerve block given during breast surgery helps reduce pain after surgery.
Who is this for?
Women scheduled to have a partial mastectomy or lumpectomy.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomized into 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Pectoral Nerve Block (PECS), by injection, during surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: No Intervention</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard care</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A PECS block is a procedure used during surgery. </li> <li class="seamTextUnorderedListItem">During your surgery, a local anesthesia will be injected into the muscles of your chest and arm pit. </li> <li class="seamTextUnorderedListItem">This injection will numb the nerves in the area where the surgery will be performed, and this may decrease the pain you feel after your surgery is over. </li> <li class="seamTextUnorderedListItem">Bupivacaine hydrochloride (Marcaine™) will be the drug used during surgery for the Pectoral Nerve Block (PECS).</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04086394' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/partial-mastectomy' target='_blank'>NCI Dictionary of Cancer Terms: Partial Mastectomy</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Bupivacaine' target='_blank'>Wikipedia: Bupivacaine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504333/' target='_blank'>Journal Article: Pectoral Nerve Block in Anesthesia for Modified Radical Mastectomy</a> </li></ul>
26
NEAREST SITE: 2539 miles
Memoral Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge,NJ
VISITS: Coincides with surgery
PHASE: III
NCT ID: NCT04241341
Axillary Lymph Node Dissection with or without Immediate Lymph Reconstruction to Prevent Lymphedema
A Randomized Controlled Trial: Does Immediate Lymphatic Reconstruction Decrease the Incidence of Lymphedema After Axillary Lymph Node Dissection Scientific Title
Purpose
To study whether having immediate lymphatic reconstruction (ILR) during an axillary lymph node dissection (removal of lymph nodes from the underarm area) reduces a woman's risk of developing lymphedema.
Who is this for?
Women planning to have an axillary lymph node dissection.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND)</li> <li class="seamTextUnorderedListItem">Lymphatic reconstruction immediately following your ALND</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Quality of life questionnaires</li> <li class="seamTextUnorderedListItem">Standard lymphedema measurements, every 6 months for 2 years</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lymphedema is a painful swelling of the hand, wrist, or arm that can occur after breast cancer surgery. </li> <li class="seamTextUnorderedListItem">Axillary lymph node dissection (ALND) is a surgical procedure done to see if the cancer has spread to the lymph nodes located in your armpit (axilla). It can increase your risk for lymphedema. </li> <li class="seamTextUnorderedListItem">Immediate lymphatic reconstruction is a procedure that will be performed immediately after your ALND and is designed to improve lymphatic drainage.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04241341' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/lymphedema' target='_blank'>Breastcancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/cancer/breast-cancer/treatment/surgery-for-breast-cancer/lymph-node-surgery-for-breast-cancer.html' target='_blank'>American Cancer Society: Lymph Node Surgery for Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/oncolog/advances-in-surgical-management-of-lymphedema.h13-1591413.html' target='_blank'>MD Anderson Cancer Center: Advances in Surgical Management of Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/lymphedema-what-are-your-surgical-options' target='_blank'>Johns Hopkins Medicine: Lymphedema, What Are Your Surgical Options?</a> </li></ul>
27
NEAREST SITE: 2561 miles
Memorial Sloan Kettering Bergen
Montvale,NJ
VISITS: 8 to 10 times for 2-3 years, then once a year for 2-3 years
PHASE: NA
NCT ID: NCT00823654
Measuring Hormone Levels to Study How Cancer Treatments & Inherited BRCA 1/2 Mutations Affect The Ovaries
Multi-Center Study of Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer and Lymphoma Scientific Title
Purpose
To study if a blood test that measures hormones can predict who will enter early menopause or develop fertility issues because of how chemotherapy and hormone therapy affect the ovaries; and to study the fertility and sexual health of women with inherited BRCA 1 or BRCA 2 mutations.
Who is this for?
Premenopausal women, 44 or younger, with DCIS or stage I, stage II, or stage III breast cancer planning to receive chemotherapy or tamoxifen. You may also enroll if you do not have breast cancer but have an inherited BRCA 1 or BRCA 2 mutation.
Full eligibility criteria
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<p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Women with DCIS or stage I-III breast cancer</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws, 8-10 times for 2-3 years, then once a year for 2-3 years (5 years total)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Women with inherited BRCA mutations</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draws, 5 times for the first year, then optional draws once a year for 4 years (5 years total)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer treatments can affect the ovaries, which may cause early menopause or difficulty becoming pregnant. </li> <li class="seamTextUnorderedListItem">Ovarian functioning can be assessed by evaluating the blood levels of certain hormones the ovaries produce.</li> <li class="seamTextUnorderedListItem">Inherited BRCA 1/2 mutations may affect your ovaries.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00823654' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youngsurvival.org' target='_blank'>Young Survival Coalition</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.facingourrisk.org/index.php' target='_blank'>FORCE: Facing Our Risk of Cancer Empowered</a> </li></ul>
28
NEAREST SITE: 2691 miles
Massachusetts General Hospital
Boston,MA
VISITS: Coincides with standard follow-up care
PHASE: NA
NCT ID: NCT01521741
Impact of Lymphedema on Quality of Life after Breast Cancer
Prospective Analysis of Symptoms, Functionality and Quality of Life Questionnaires to Evaluate Lymphedema in Patients Following Treatment for Breast Cancer. Scientific Title
Purpose
To determine how the symptoms and functional disability that accompany lymphedema can impact breast cancer survivors' quality of life.
Who is this for?
Women with breast cancer and without brain metastasis or axillary lymph node malignancy
Full eligibility criteria
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<p class="seamTextPara"> All participants will complete the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires and arm measurements</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Breast cancer treatments can result in long-term, painful swelling of the arm and hand, a condition called lymphedema. </li> <li class="seamTextUnorderedListItem">To be eligible, participants must be planning to have surgery and receive follow-up care for breast cancer at Massachusetts General Hospital.</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01521741' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/search.jsp?terms=lymphedema' target='_blank'>BreastCancer.org: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/pdq/supportivecare/lymphedema/Patient/page1' target='_blank'>NCI: Lymphedema</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/Treatment/TreatmentsandSideEffects/PhysicalSideEffects/Lymphedema/WhatEveryWomanwithBreastCancerShouldKnow/lymphedema-what-every-woman-with-breast-cancer-should-know-toc' target='_blank'>ACS: Lymphedema</a> </li></ul>
29
NEAREST SITE: 2693 miles
Beth Israel Deaconess Medical Center
Boston,MA
VISITS: Number of visits unavailable, over 1 year
PHASE: NA
NCT ID: NCT02666378
Detecting Treatment-Related Cardiotoxicity in HER2 Positive Breast Cancer
Imaging Markers of Subclinical Cardiotoxicity in Breast Cancer Scientific Title
Purpose
To determine whether Cardiac Magnetic Resonance Imaging (CMR) and Echocardiogram (ECHO) tests can be used to identify early signs of heart problems that can be caused by Doxil and Herceptin.
Who is this for?
Women with HER2 positive breast cancer who are going to be treated with doxorubicin (Doxil®) and trastuzumab (Herceptin®) after surgery.
Full eligibility criteria
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<p class="seamTextPara"> You will undergo the following before treatment with chemotherapy and at predetermined times during and after treatment: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MRI (Cardiac Magnetic Resonance Imaging, CMR)</li> <li class="seamTextUnorderedListItem">Ultrasound (Echocardiogram, ECHO)</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is investigating whether Cardiac Magnetic Resonance Imaging (CMR) and Echocardiogram (ECHO) tests can be used to identify early signs of heart problems that can be caused by Doxil and Herceptin.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02666378' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/tx-w-herceptin-needs-heart-monitoring' target='_blank'>Breastcancer.org: Women Treated With Herceptin Need Heart Monitoring</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/heart-meds-reduce-herceptin-cardiac-damage' target='_blank'>Breastcancer.org: Medicine for Herceptin Related Heart Damage</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20111005' target='_blank'>Breastcancer.org: Herceptin Related Heart Damage</a> </li></ul>
