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Find Breast Cancer Clinical Trials That Are Right For You

The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.

Use the search box and filters to find a trial that’s right for you.


Currently viewing trials
(Last updated: March 18, 2023)

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Treatment

Brain Mets

BRCA1/2 (inherited)

Chemotherapy

Hormone Therapy

Leptomeningeal Disease

Radiation Oncology

Surgery

Surgery: Reconstruction

Targeted Therapy: All

Targeted Therapy: Anti-HER2 Therapy

Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

Targeted Therapy: Other Targeted Therapy

Vaccines and Immunotherapy

Other Treatment

Non-Treatment

Activities

Complementary and Alternative Medicine

Decision Support

Diagnosing Breast Cancer

Genetics/Family History

Having Children

Lymphedema

Managing Side Effects

No Travel Required

Predicting Response to Treatment

Preventing Breast Cancer

Preventing Recurrence

Screening

Support/Education

Surveys/Interviews/Registries

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AKT

ALK

AR

BARD1

BRCA1/2 (tumor)

BRIP1

CD205

CD70

CHEK2 or CHEK1

ESR1

FGFR

HER2/ERBB2

HLA

MET or C-Met

NTRK

PALB2

PIK3CA or PI3K

PTEN

RAD51

RAF (including BRAF)

RAS (KRAS or NRAS)

RB

ROS1

TP53

Click here to view online studies and trials that do not require site visits

1

NEAREST SITE: 341 miles
Cedars-Sinai Medical Center
Los Angeles,CA

VISITS: 3 visits over 6 months

PHASE: II

NCT ID: NCT04189263

Low Carbohydrate Diet for Postmenopausal Women Starting Aromatase Inhibitors for Breast Cancer

IIT2018-21-Amersi-BREADS BREADS: Breast Adjuvant Diet Study Scientific Title

Purpose
To study if a low carbohydrate diet affects weight, hormone levels and other health factors in women taking an aromatase inhibitor.
Who is this for?
Postmenopausal women with stage I, stage II, stage III or metastatic (stage IV) hormone positive (ER+ and/or PR+) breast cancer with a BMI >=24 who intend to start taking a type of anti-estrogen therapy called an aromatase inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Low carbohydrate diet</li> <li class="seamTextUnorderedListItem">Support calls from a dietician</li> <li class="seamTextUnorderedListItem">Physician's choice of aromatase inhibitor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Physician's choice of aromatase inhibitor</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A low carbohydrate diet may help some women lose weight and it may affect other health factors such as hormone levels, cholesterol, glucose and insulin.</li> <li class="seamTextUnorderedListItem">The three approved aromatase inhibitors are anastrozole (Arimidex®), exemestane (Aromasin®) and letrozole (Femara®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04189263' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://osher.ucsf.edu/patient-care/integrative-medicine-resources/cancer-and-nutrition/faq/low-carbohydrate-diet' target='_blank'>UCSF Osher Center for Integrative Medication: Low Carbohydrate Diet</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fredhutch.org/en/news/center-news/2019/10/keto-fat-cancer-its-complicated.html' target='_blank'>Fred Hutchison Cancer Research Center: Keto, Fat and Cancer, It's Complicated</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Aromatase_inhibitor' target='_blank'>Wikipedia: Aromatase Inhibitor</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors' target='_blank'>Breastcancer.org: Aromatase Inhibitors</a> </li></ul>
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2

NEAREST SITE: 348 miles
USC Norris Comprehensive Cancer Center
Los Angeles,CA

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT01802346

Low-Calorie Diet To Reduce Side Effects of Chemotherapy

A Randomized, Phase II Clinical Trial of a Controlled Diet Prior to Selected Chemotherapy Treatment in Breast and Prostate Cancer to Evaluate the Impact on Toxicity and Efficacy Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of
Who is this for?
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Participants will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eat a special low-calorie diet during before, during and after chemotherapy (All food provided)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Eat a normal diet, receive dietary advice from a nutritionist</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01802346' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/chemotherapy/side_effects' target='_blank'>BreastCancer.org: Chemotherapy Side Effects</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-treating-chemotherapy' target='_blank'>Cancer.gov: Chemotherapy</a> </li></ul>
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3

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 10-12 visits over 8 weeks

PHASE: II

NCT ID: NCT02754752

Acupuncture for Relieving Severe Post-Mastectomy Pain

Randomized-Controlled Trial of Acupuncture for Post-Mastectomy Pain Syndrome Scientific Title

Purpose
To study the safety, effects (good and bad), and anti-cancer activity of
Who is this for?
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Acupuncture on specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Acupuncture on non-specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Wait-List</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No acupuncture</li> <li class="seamTextUnorderedListItem">After 4 weeks, optional participation in up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02754752' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/pain/post-mastectomy-pain-syndrome.html' target='_blank'>American Cancer Society: Post-mastectomy Pain Syndrome</a> </li></ul>
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4

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT05198843

Dasatinib With Omega-3 Dietary Supplement for Metastatic Triple Negative Inflammatory Breast Cancer

Phase Ib/II Study of EPA-Based EphA2 Targeted Therapy for Patients With Metastatic Triple-Negative Inflammatory Breast Cancer Scientific Title

Purpose
To study the safety, best dose, effects (good and bad), and anti-cancer activity of dasatinib (Sprycel®), a targeted therapy called a tyrosine kinase inhibitor, with icosapent ethyl (Vascepa®), an omega-3 dietary supplement.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) inflammatory breast cancer (IBC) that has progressed on standard treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Icosapent ethyl (Vascepa®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®) is a type of targeted therapy called a tyrosine kinase inhibitor. Tyrosine kinase inhibitors work by blocking proteins that signal cancer cells to multiply, which may help keep cancer cells from growing.</li> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®) is approved for treatment of other cancers.</li> <li class="seamTextUnorderedListItem">Icosapent ethyl (Vascepa®) is an omega-3 fatty acid dietary supplement. It may decrease the amount of fats made in the liver and may reduce the growth of triple negative inflammatory breast cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05198843' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/types/inflammatory' target='_blank'>Breastcancer.org: Inflammatory Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/dasatinib' target='_blank'>Cancer Research UK: Dasatinib (Sprycel®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a613024.html' target='_blank'>MedlinePlus: Icosapent Ethyl (Vascepa®)</a> </li></ul>
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5

NEAREST SITE: 1832 miles
Medical College of Wisconsin
Milwaukee,WI

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03824145

Every Day Counts Lifestyle Program to Improve Quality of Life for Women with Metastatic Breast Cancer

Every Day Counts: A Lifestyle Program for Women With Metastatic Breast Cancer Scientific Title

Purpose
To study whether the Every Day Counts lifestyle program improves the quality of life of women with metastatic breast cancer.
Who is this for?
Women with metastatic (stage IV) breast cancer that is currently stable and who live in Milwaukee, Wisconsin or Chicago, Illinois.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Every Day Counts lifestyle program, 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Home/work organization intervention, 4 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Every Day Counts lifestyle program promotes nutritional and physical activity changes based on the American Cancer Society nutrition and physical activity guidelines.</li> <li class="seamTextUnorderedListItem">The Every Day Counts lifestyle program consists of: 1) a curriculum binder covering weekly topics and including self-monitoring tools to support adherence; 2) lifestyle coaching for 16-weeks, with in-person or virtual supervised exercise sessions and telephone-based sessions; 3) exercise supplies (Fitbit, resistance bands), 4) twice weekly text messaging targeting self-efficacy and social support; and 5) attendance to cooking classes emphasizing plant-based eating.</li> <li class="seamTextUnorderedListItem">The home/work organization intervention consists of: 1) a book with overview of home/work organization program with 16 weekly topics with an overview of each chapter, 2) virtual or weekly phone calls with a home organization coach with standard prompts, 3) text messages supporting home/work organization.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03824145' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/healthy/eat-healthy-get-active/acs-guidelines-nutrition-physical-activity-cancer-prevention/guidelines.html' target='_blank'>American Cancer Society: Guideline for Diet and Physical Activity</a> </li></ul>
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6

NEAREST SITE: 1853 miles
University of Illinois Chicago
Chicago,IL

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05259410

Time Restricted Eating During Chemotherapy for Women with Stage I-III Breast Cancer

The Safety and Efficacy of Time Restricted Eating Combined With Chemotherapy During Breast Cancer Treatment Scientific Title

Purpose
To study whether time restricted eating during chemotherapy improves treatment-related outcomes and quality of life and limits treatment-related side effects and weight gain.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Time restricted eating, 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No time restricted eating, 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Time restricted eating, a form of intermittent fasting, is eating all food within the hours of 10:00am and 6:00pm, with water fasting the remaining hours of the day.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05259410' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/intermittent-fasting-may-help-cancer-treatments-work-better' target='_blank'>Breastcancer.org: Intermittent Fasting May Help Cancer Treatments Work Better</a> </li></ul>
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7

NEAREST SITE: 1958 miles
Vanderbilt-Ingram Cancer Center
Nashville,TN

VISITS: Number of visits unavailable, over 2 weeks

PHASE: NA

NCT ID: NCT03962647

Keto Diet and Letrozole Before Surgery in Women with Stage I-III, ER+, HER2- Breast Cancer with a BMI >=30

A Pilot and Feasibility Neoadjuvant Study of a 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+ Breast Cancer Scientific Title

Purpose
To study the effects the ketogenic, or keto, diet has on breast cancer cells in patients who are taking the anti-estrogen drug letrozole (Femara®) before surgery.
Who is this for?
Postmenopausal women with stage I, stage II, or stage III estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have a BMI >=30.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> Before surgery, you will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, daily, for 2 weeks</li> <li class="seamTextUnorderedListItem">Ketogenic meal replacement shakes, for 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The keto diet is typically high in fat and low in carbohydrates. </li> <li class="seamTextUnorderedListItem">In this study, you will be given meal replacement shakes that mimic a keto diet. </li> <li class="seamTextUnorderedListItem">The keto diet affects the amount of glucose in the body. Reducing glucose may affect how quickly cancer cells grow.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03962647' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fredhutch.org/en/news/center-news/2019/10/keto-fat-cancer-its-complicated.html' target='_blank'>Fred Hutchinson Cancer Research Center: Keto, Fat and Cancer, It's Complicated</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors/femara' target='_blank'>Breastcancer.org: Letrozole</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.vanderbiltcancer.org/clinical-trials/protocol-viccbre18108' target='_blank'>Vanderbilt-Ingram Cancer Center: Study page</a> </li></ul>
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8

NEAREST SITE: 2137 miles
Emory University Hospital Midtown
Atlanta,GA

VISITS: 1 visit every day for 2 weeks

PHASE: NA

NCT ID: NCT05368428

Transcutaneous Electrical Nerve Stimulation for Chemotherapy Induced Peripheral Neuropathy in People with Stage I-III Breast Cancer

Single-Institution Trial Investigating the Effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) in Taxane Induced Peripheral Neuropathy (CIPN) in Patients With Early Stage Breast Cancer Scientific Title

Purpose
To determine if transcutaneous electrical nerve stimulation (TENS) reduces chemotherapy induced peripheral neuropathy (CIPN).
Who is this for?
People with stage I, stage II, or stage III breast cancer who are receiving chemotherapy and have chemotherapy induced peripheral neuropathy (CIPN).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Transcutaneous electrical nerve stimulation (TENS), daily for 2 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy induced peripheral neuropathy (CIPN) is nerve pain in your hands and feet as a side effect of chemotherapy.</li> <li class="seamTextUnorderedListItem">Neuropathy is pain from nerve damage.</li> <li class="seamTextUnorderedListItem">Transcutaneous electrical nerve stimulation (TENS) involves mild electric currents applied to some areas of your skin to potentially improve neuropathy.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05368428' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://my.clevelandclinic.org/health/treatments/15840-transcutaneous-electrical-nerve-stimulation-tens' target='_blank'>Cleveland Clinic: Transcutaneous Electrical Nerve Stimulation (TENS)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/neuropathy' target='_blank'>Breastcancer.org: Neuropathy</a> </li></ul>
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9

NEAREST SITE: 2299 miles
Roswell Park Cancer Institute
Buffalo,NY

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT03679559

Three Month Exercise Program for People with Stage I-III Breast Cancer Who Have Completed Treatment

Exercise to Improve Health and Quality-of-Life in Breast Cancer Survivors: A Feasibility Pilot Trial Scientific Title

Purpose
To study and compare how different exercise programs affect health and quality of life.
Who is this for?
People diagnosed with stage I, stage II, or stage III breast cancer who have completed treatment--though you can still enroll if you are currently taking anti-hormone therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 4 groups and receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Walking and resistance training</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking sessions tracked by a Fitbit, 30 minutes a day, 5 days a week, for 3 months </li> <li class="seamTextUnorderedListItem">Resistance training sessions using a training DVD and TheraBand exercise bands, 6 times over 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Zumba and resistance training</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Zumba or other classes on an XBOX while wearing a Fitbit, 50 minutes a day, 3 days a week, for 3 months</li> <li class="seamTextUnorderedListItem">Resistance training sessions using a training DVD and TheraBand exercise bands, 6 times over 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: HIIT and resistance training</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Supervised HIIT sessions while wearing a Fitbit, 3 days a week, for 3 months</li> <li class="seamTextUnorderedListItem">Resistance training sessions using a training DVD and TheraBand exercise bands, 6 times over 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4: Usual physical activity</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will wear a Fitbit to monitor your physical activity, for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Research suggests that regular exercise decreases fatigue in breast cancer survivors and generally improves quality of life.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03679559' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.fredhutch.org/en/news/center-news/2014/06/breast-cancer-patients-exercise.html' target='_blank'>Fred Hutchinson Cancer Research Center: Most Breast Cancer Patients Don't Get Enough Exercise</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/news-events/cancer-currents-blog/2020/breast-cancer-survival-exercise' target='_blank'>NCI Cancer Currents Blog: Exercise and Survival for Women with Breast Cancer</a> </li></ul>
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10

NEAREST SITE: 2351 miles
University of Florida
Gainesville,FL

VISITS: 1 visit every 1-3 weeks for 3 months

PHASE: I-II

NCT ID: NCT05074290

Epidiferphane Nutritional Supplement with Chemotherapy for Stage I-IV Breast Cancer

Pharmacokinetics and Safety of Epidiferphane and Taxanes in Breast Cancer Patients Scientific Title

Purpose
To study the safety, best dose, effects (good and bad), and anti-cancer activity of epidiferphane, an experimental nutritional supplement, with chemotherapy.
Who is this for?
People with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who are planning on receiving treatment with chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Epidiferphane, by mouth, daily for 3 months</li> <li class="seamTextUnorderedListItem">Physician's choice of chemotherapy: Docetaxel (Taxotere®), every 3 weeks; paclitaxel (Taxol®), weekly; or nab-paclitaxel (Abraxane®), weekly; 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Epidiferphane is an experimental nutritional supplement that may reduce chemotherapy symptoms.</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), paclitaxel (Taxol®), and nab-paclitaxel (Abraxane®) are chemotherapy drugs.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with lobular breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05074290' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/epidiferphane' target='_blank'>National Cancer Institute: Epidiferphane</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/chemotherapy' target='_blank'>Breastcancer.org: Chemotherapy</a> </li></ul>
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11

NEAREST SITE: 2352 miles
University of Rochester Medical Center
Rochester,NY

VISITS: At least 8 visits

PHASE: NA

NCT ID: NCT04230941

MAAT-G Workshops and Workbook to Improve Cognition for People Ages 65+ With Breast Cancer After Completing Treatment

Mitigating Cancer-Related Cognitive Impairment in Older Adults With Breast Cancer Receiving Chemotherapy: Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase I Scientific Title

Purpose
To study if the MAAT-G intervention can improve or maintain cognition for older adults after completing breast cancer treatment.
Who is this for?
People ages 65 or older with stage I, stage II, or stage III breast cancer who have completed standard treatment with chemotherapy and have mild cognitive problems.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MAAT-G intervention, 8 workshops and workbook</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for trial schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Memory and Attention Adaptation Training (MAAT) is a cognitive-behavioral therapy (CBT)-based intervention for cancer-related cognitive problems.</li> <li class="seamTextUnorderedListItem">MAAT is a series of workshops delivered by a psychologist via video-conferencing, supplemented by a workbook, which provides instruction and practice with behavioral coping skills, stress management techniques, and other support strategies. </li> <li class="seamTextUnorderedListItem">MAAT is used for younger cancer survivors, but needs to be adapted for older adults to address their unique needs. </li> <li class="seamTextUnorderedListItem">Memory and Attention Adaptation Training-Geriatrics (MAAT-G) is MAAT for people over the age of 65.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04230941' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20100913' target='_blank'>Breastcancer.org: Older Women More Likely to Have Chemo-Related Cognitive Problems</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/podcast/chemobrain-update' target='_blank'>Breastcancer.org (Podcast): Chemo Brain Update: Cancer-Related Cognitive Decline</a> </li></ul>
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12

NEAREST SITE: 2353 miles
University of Florida CTSI Clinical Research Center
Gainesville,FL

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05473026

Gratitude Journaling and Goal Setting for Black Women with Breast Cancer and Breast Cancer Survivors

A Pilot Feasibility Study of a Gratitude Journaling Intervention to Enhance Well-being and Exercise Readiness in Older African American Female Breast Cancer Survivors Scientific Title

Purpose
To study the ability of gratitude journaling and goal setting to promote exercise and well-being.
Who is this for?
Black women with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who have received chemotherapy after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gratitude journaling, daily for 2 months</li> <li class="seamTextUnorderedListItem">Goal setting, daily for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General journaling, daily for 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will receive a journal (paperback or electronic) and a daily journaling prompt depending on your group assignment.</li> <li class="seamTextUnorderedListItem">Goal setting will be based on the American Cancer Society's Nutrition, Physical Activity, and Cancer toolkit.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05473026' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/cancerwise/cultivating-gratitude-and-hope.h00-158905389.html' target='_blank'>MD Anderson Cancer Center: Gratitude During Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://copingmag.com/gratitude-for-cancer-survivors/#:~:text=For%20cancer%20survivors%2C%20practicing%20gratitude,constantly%20about%20their%20cancer%20returning.' target='_blank'>Coping Magazine: Gratitude for Cancer Survivors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/healthy/eat-healthy-get-active/acs-guidelines-nutrition-physical-activity-cancer-prevention/guidelines.html' target='_blank'>American Cancer Society: Guideline for Diet and Physical Activity</a> </li></ul>
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13

NEAREST SITE: 2436 miles
MedStar Washington Hospital Center
Washington,DC

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05233800

Faster Asleep Smart Speaker for Sleep Problems in Women with Breast Cancer

Testing mHealth Delivery of Cognitive Behavioral Therapy for Insomnia to Breast Cancer Survivors Scientific Title

Purpose
To study if the Faster Asleep Smart Speaker Program can reduce insomnia and help you sleep better.
Who is this for?
Women with stage I, stage II, stage III, or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Faster Asleep Smart Speaker Program, daily for 6 weeks</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Faster Asleep Website</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Faster Asleep Smart Speaker Program includes a speaker that can be activated by your voice or smartphone app. It automatically delivers components of cognitive behavioral therapy for insomnia (sleep problems).</li> <li class="seamTextUnorderedListItem">The Faster Asleep Website has information about cognitive behavioral therapy for insomnia (sleep problems) in people with breast cancer, including information from the Faster Asleep Smart Speaker Program script.</li> <li class="seamTextUnorderedListItem">Cognitive behavioral therapy helps connect the way we think, the things we do, and how we sleep.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05233800' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.sleepfoundation.org/insomnia/treatment/cognitive-behavioral-therapy-insomnia' target='_blank'>Sleep Foundation: Cognitive Behavioral Therapy for Insomnia</a> </li></ul>
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14

NEAREST SITE: 2519 miles
Sidney Kimmel Cancer Center at Thomas Jefferson Univeristy
Philadelphia,PA

VISITS: 5 visits

PHASE: II

NCT ID: NCT04959474

Reducing Calories During Radiation Therapy for DCIS or Stage I-III Breast Cancer

SABR-CaRe: A Phase II Randomized Trial of Pre-Operative Stereotactic Ablative Radiation Therapy (SABR) With and Without Caloric Restriction for Early Stage Breast Cancer Scientific Title

Purpose
To determine if neoadjuvant (before surgery) calorie restriction during radiation therapy decreases the size of tumor tissue, compared to radiation therapy alone.
Who is this for?
People age 40 and older with DCIS, stage I, stage II, or stage III node negative breast cancer or age 50 and older if you have triple negative (ER-, PR-, HER2-) breast cancer. You must have not yet received chemotherapy, radiation, or surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic ablative radiation therapy (SABR) is a highly focused radiation treatment that gives an intense dose of radiation concentrated on a tumor, while limiting the dose to the surrounding organ.</li> <li class="seamTextUnorderedListItem">Giving SABR before surgery may make the tumor smaller.</li> <li class="seamTextUnorderedListItem">Adding dietary restriction to radiation therapy may help increase the effectiveness of the radiation and decrease the spread of the cancer to other places in the body.</li> <li class="seamTextUnorderedListItem">The reduced calorie diet consists of reducing your calorie intake by 25%.</li> <li class="seamTextUnorderedListItem">Neoadjuvant therapy is when you receive treatment before surgery. Doctors use it to shrink tumors and to see how your cancer responds to the given therapies.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04959474' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://stanfordhealthcare.org/medical-treatments/s/stereotactic-body-radiation-therapy.html#:~:text=Stereotactic%20ablative%20radiotherapy%20(SABR)%2C,dose%20to%20the%20surrounding%20organs.' target='_blank'>Stanford: Stereotactic Ablative Radiation Therapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.jefferson.edu/university/jmc/departments/radiation_oncology/news/07212014.html' target='_blank'>Thomas Jefferson University: Calorie Restriction and Breast Cancer</a> </li></ul>
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15

NEAREST SITE: 2531 miles
Virtua Health
Voorhees,NJ

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05704842

Exercise to Reduce Fatigue During Chemotherapy for Women with Stage I-III Breast Cancer

Pilot Study to Evaluate the Impact of a Home-Based Exercise Program on Cancer-Related Fatigue in Breast Cancer Patients Undergoing Curative-Intent Chemotherapy Scientific Title

Purpose
To study if exercise reduces fatigue during treatment with chemotherapy.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who plan to receive chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visit with physical therapist</li> <li class="seamTextUnorderedListItem">Complete home-based exercise program</li> <li class="seamTextUnorderedListItem">Complete online surveys, weekly</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard Treatment</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Complete online surveys, weekly</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The home-based exercise program includes exercises such as: core stabilization, core extension, leg extensions, squats with and without weights, shoulder exercises, and arm exercises.</li> <li class="seamTextUnorderedListItem">The online surveys will assess your symptoms and fatigue.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05704842' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/fatigue' target='_blank'>Breastcancer.org: Cancer Fatigue</a> </li></ul>
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16

NEAREST SITE: 2539 miles
Memoral Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03988595

Exercise With Hormone Therapy for Metastatic HR+, HER2- Breast Cancer

Phase 1a/1b Trial of Exercise Treatment With Concurrent First-Line Therapy for Hormone Receptor Positive Metastatic Breast Cancer Scientific Title

Purpose
To study the effects (good and bad) and anti-cancer activity of exercise with hormone therapy.
Who is this for?
Women with stage IV (metastatic) hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who are receiving or planning to receive their first hormone therapy for metastatic disease and engage in less than 1 hour of exercise per week.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will complete the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking, 1.5-6 hours per week for 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise may delay the development of resistance to hormone therapy while slowing the growth of tumors.</li> <li class="seamTextUnorderedListItem">Exercise sessions will be remotely (online) monitored with TeleEx.</li> <li class="seamTextUnorderedListItem">You will also be given a device to track your daily general physical activity.</li> <li class="seamTextUnorderedListItem">Premenopausal and perimenopausal women will also be given a drug that will put women in temporary menopause.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03988595' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/exercise' target='_blank'>Breastcancer.org: Exercise</a> </li></ul>
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17

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT05716893

Exercise During Chemotherapy for People with Stage I-III Breast Cancer

Phase 2 Trial of Adaptive Versus Standard Dosing of Aerobic Training in Patients Receiving Chemotherapy for Primary Breast Cance Scientific Title

Purpose
To study how 2 types of walking aerobic training affect cardiorespiratory fitness.
Who is this for?
Women with newly diagnosed stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy. You must not be performing more than 1.5 hours of exercise per week.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Adaptive Aerobic Training</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking aerobic training, 1.5-5 hours per week for 1 year</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard (Fixed) Aerobic Training</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking aerobic training, 1.5 hours per week for 1 year</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cardiorespiratory fitness (CRF) is the ability of your heart and lungs to deliver oxygen to your body’s muscles and organs during physical activity.</li> <li class="seamTextUnorderedListItem">Aerobic exercise refers to cardiovascular exercise, which includes activities such as walking, running, biking, and swimming.</li> <li class="seamTextUnorderedListItem">Adaptive aerobic training consists of changing the amount of exercise depending on your response.</li> <li class="seamTextUnorderedListItem">Standard (fixed) aerobic training consists of a fixed, constant amount of exercise.</li> <li class="seamTextUnorderedListItem">Some of your walking will be supervised remotely (online).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05716893' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/patient-education/exercise-during-after-cancer-treatment-level-1' target='_blank'>Memorial Sloan Kettering Cancer Center: Exercise During and After Cancer Treatment</a> </li></ul>
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18

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: At least 1 visit per month

PHASE: II

NCT ID: NCT05090358

Preventing High Blood Sugar in People with Metastatic ER+, HER2- Breast Cancer with a PIK3CA Mutation

Targeting Insulin Feedback to Enhance Alpelisib (TIFA): A Phase 2 Randomized Control Trial in Metastatic PIK3CA-mutant Hormone-Receptor Positive Breast Cancer Scientific Title

Purpose
To determine if a ketogenic or low carbohydrate diet with canagliflozin (Invokana®), a high blood pressure drug, or canagliflozin (Invokana®) alone can prevent high blood sugar.
Who is this for?
Post-menopausal women and men with metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer with a PIK3CA mutation who have not received chemotherapy or more than 1 line of hormone therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ketogenic diet</li> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®), by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), injection, every 2 weeks for 1 month, then monthly</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Low carbohydrate diet</li> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®), by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), injection, every 2 weeks for 1 month, then monthly</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®), by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), injection, every 2 weeks for 1 month, then monthly</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The ketogenic diet consists of low carbohydrates and high fat.</li> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®) is a drug approved for treating high blood sugar for people with type 2 diabetes. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a type of hormone therapy called a selective estrogen receptor degrader (SERD).</li> <li class="seamTextUnorderedListItem">SERDs work by binding to and breaking down estrogen receptors.</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®) is a type of targeted therapy called a PI3K inhibitor.</li> <li class="seamTextUnorderedListItem">If there is a mutation in the PIK3CA gene, the PI3K pathway can become overactivated, which allows cancer cells to grow. PI3K inhibitors block the PI3K pathway.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05090358' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://osher.ucsf.edu/patient-care/integrative-medicine-resources/cancer-and-nutrition/faq/low-carbohydrate-diet' target='_blank'>UCSF Osher Center for Integrative Health: Low Carbohydrate Diet and Ketogenic Diet</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healthline.com/nutrition/low-carb-vs-keto' target='_blank'>Healthline: Low Carbohydrate Diet and Ketogenic Diet</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.invokana.com/' target='_blank'>Janssen Drug Information Page: Canagliflozin (Invokana®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/faslodex' target='_blank'>Breastcancer.org: Fulvestrant (Faslodex®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted-therapy/piqray' target='_blank'>Breastcancer.org: Alpelisib (Piqray®)</a> </li></ul>
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19

NEAREST SITE: 2569 miles
Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center
New York,NY

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT04973930

Tele-Interpersonal Psychotherapy or Medication for People with Depression and Breast Cancer

Pilot Randomized Feasibility Trial of Tele-Interpersonal Psychotherapy and Tele-Pharmacotherapy for Depression in Patients With Non-Metastatic Breast Cancer Scientific Title

Purpose
To study if tele-interpersonal psychotherapy (IPT) and/or medication decreases symptoms of depression.
Who is this for?
People with stage I, stage II, or stage III breast cancer and depression. You must not be currently receiving treatment for depression.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tele-interpersonal psychotherapy (IPT), by Zoom, once a week, for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Venlafaxine (Effexor®) or escitalopram (Lexapro®), by mouth, daily for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Requires blood tests and questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Interpersonal psychotherapy (IPT) is a type of therapy that focuses on the connection between upsetting life circumstances (such as diagnosis of breast cancer) and their effect on mood. It is known to lower symptoms of depression.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, you will receive tele-IPT virtually through Zoom videoconferencing software. </li> <li class="seamTextUnorderedListItem">Venlafaxine (Effexor®) and escitalopram (Lexapro®) are two types of approved anti-depression treatments called serotonin reuptake inhibitors.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, you will meet with a doctor virtually to discuss your treatment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04973930' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/depression' target='_blank'>Breastcancer.org: Depression and Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.psychologytoday.com/us/therapy-types/interpersonal-psychotherapy' target='_blank'>Psychology Today: Interpersonal Psychotherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Venlafaxine-(Effexor)' target='_blank'>National Alliance on Mental Illness: Venlafaxine (Effexor®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Escitalopram-(Lexapro)' target='_blank'>National Alliance on Mental Illness: Escitalopram (Lexapro®)</a> </li></ul>
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20

NEAREST SITE: 2693 miles
Massachusetts General Hospital
Boston,MA

VISITS: Number of visits unavailable, before surgery

PHASE: I

NCT ID: NCT03596073

Topical Ointment Calcipotriene Before Surgery to Stimulate Immune Cells

A Pilot Trial of Topical Calcipotriene Treatment for Breast Cancer Immunoprevention Scientific Title

Purpose
To see the effect that a topical ointment called calcipotriene has on the tumor's microenvironment.
Who is this for?
People who are 45 or older, scheduled to have breast cancer surgery, and not receiving chemotherapy before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Topical calcipotriene ointment, 2 times per day, for the period between biopsy and surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Topical vaseline, 2 times per day, for the period between core biopsy and surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Calcipotriene is a man-made form of vitamin D.</li> <li class="seamTextUnorderedListItem">It is approved by the FDA to treat psoriasis. Its use in breast cancer is experimental. </li> <li class="seamTextUnorderedListItem">Giving the treatment before surgery allows researchers to look at how it affects the tumor's microenvironment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03596073' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-1506/calcipotriene-topical/details' target='_blank'>WebMD: Calcipotriene</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/1672178' target='_blank'>Pubmed: Topical calcipotriol treatment in advanced breast cancer</a> </li></ul>
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21

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: 1-2 visits per week for 3 months

PHASE: NA

NCT ID: NCT05528263

Acupuncture to Prevent Chemotherapy-Induced Peripheral Neuropathy for People with Stage I-III Breast Cancer

Preventing Chemotherapy-Induced Peripheral Neuropathy With Acupuncture, A Randomized Controlled Trial (PACT Trial) Scientific Title

Purpose
To study the ability of acupuncture to prevent chemotherapy-induced peripheral neuropathy (CIPN).
Who is this for?
People with stage I, stage II, or stage III breast cancer who are planning to receive chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acupuncture, 1-2 times per week for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Nature scenery video with relaxation exercise guide, 1-2 times per week for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Chemotherapy-induced peripheral neuropathy (CIPN) is nerve pain in your hands and feet as a side effect of chemotherapy.</li> <li class="seamTextUnorderedListItem">Neuropathy is pain from nerve damage.</li> <li class="seamTextUnorderedListItem">Acupuncture is a form of complementary medicine in which thin needles are inserted into the body.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05528263' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/complementary-therapy/types/acupuncture#:~:text=Research%20on%20acupuncture%20in%20people%20with%20breast%20cancer%20and%20other%20types%20of%20cancer,-Advertisement&text=Much%20research%20is%20being%20done,nausea%2C' target='_blank'>Breastcancer.org: Acupuncture</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment-side-effects/neuropathy' target='_blank'>Breastcancer.org: Neuropathy</a> </li></ul>
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22

NEAREST SITE: 2693 miles
Dana Farber Cancer Institute
Boston,MA

VISITS: 4 visits over 8 months

PHASE: NA

NCT ID: NCT05327452

Exercise During Chemotherapy for Black and Hispanic People with Breast Cancer

Testing Home-based Exercise Strategies to Improve Exercise Participation and Cardiovascular Health in Underserved Minority Patients With Cancer Undergoing Chemotherapy: the THRIVE Study Scientific Title

Purpose
To determine whether an exercise intervention will affect physical activity levels and heart health in Black and Hispanic people with breast cancer.
Who is this for?
Black and Hispanic people newly diagnosed with stage I, stage II, or stage III breast cancer who are overweight/obese, engage in less than 90 minutes of exercise per week, and are planning to receive chemotherapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Virtually supervised home-based exercise, 3 times per week for 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Unsupervised home-based exercise, 3 times per week for 4 months</li> <li class="seamTextUnorderedListItem">Telehealth call with certified exercise trainer, 1 time per week for 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Home-based stretching, 3 times per week for 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cardiovascular and strength tests, 3 times within 8 months</li> <li class="seamTextUnorderedListItem">Questionnaires, 3 times within 8 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">All groups require 4 visits</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The home-based exercise interventions include aerobic and resistance exercises.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, the virtual supervision will occur via Zoom.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05327452' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/exercise' target='_blank'>Breastcancer.org: Exercise</a> </li></ul>
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23

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05692960

Improving Sexual Health for Women After Breast Cancer Treatment

Women's Interventions for Sexual Health: WISH, A Pilot Study Scientific Title

Purpose
To study the ability of hypnotic relaxation intervention (HRI) and Replens™ vaginal moisturizer to improve the sexual health of women after breast cancer treatment by addressing changes in body image, sexual desire, and vaginal dryness.
Who is this for?
Women with stage I, stage II, or stage III breast cancer who have completed treatment between 3 months and 5 years ago. You must experience dryness and/or pain with sexual activity and negative changes in your body image and/or sexual desire since being diagnosed with cancer.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnotic relaxation intervention (HRI) via MP3 player, 3 times per week for 1.5 months</li> <li class="seamTextUnorderedListItem">Hypnotic relaxation intervention (HRI) practice log, weekly for 1.5 months</li> <li class="seamTextUnorderedListItem">Replens™ vaginal moisturizer, every 1-2 days for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Replens™ vaginal moisturizer, every 1-2 days for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Phone calls and virtual visits, 4-5 times within 2 months</li> <li class="seamTextUnorderedListItem">Surveys, 3 times within 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The hypnotic relaxation intervention (HRI) consists of three different audio files, each about 20 minutes in length, from a trial-provided MP3 player. These three hypnotic inductions involve relaxation and subconscious suggestions that build upon each other.</li> <li class="seamTextUnorderedListItem">The first hypnotic induction audio focuses on relaxation, feelings of wellness, wholeness, strength, and confidence. The second hypnotic induction audio focuses more specifically on body image related to sexuality and being a sexual being. The third hypnotic induction audio focuses on sexual desire, passion, and energy.</li> <li class="seamTextUnorderedListItem">Vulvovaginal dryness will be treated with a daily moisturizer for two weeks, then every other day for the remaining six weeks. Replens™ vaginal moisturizer will be applied at night, before sleep and after all sexual activity.</li> <li class="seamTextUnorderedListItem">Replens™ is a non-hormonal vaginal moisturizer consisting primarily of purified water, glycerin, and mineral oil.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05692960' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/sex-intimacy' target='_blank'>Breastcancer.org: Sexual Health During and After Breast Cancer</a> </li></ul>
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24

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05452681

Improving Quality of Life of Young Black Women After Treatment

Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors Scientific Title

Purpose
To compare how Y-AMBIENT education sessions and follow up phone calls improve quality of life after breast cancer treatment.
Who is this for?
Black or African American women ages 18 to 44 years old with stage I, stage II, or stage III breast cancer who have completed treatment with chemotherapy and/or radiation.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Y-AMBIENT education sessions, 3 times within 4 months</li> <li class="seamTextUnorderedListItem">Y-AMBIENT follow up phone calls, 3 times within 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education sessions, 3 times within 4 months</li> <li class="seamTextUnorderedListItem">Follow up phone calls, 3 times within 4 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Y-AMBIENT is telephone-based intervention with education sessions designed to improve quality of life. Session 1, titled <q>My Self, My Soul,</q> covers topics related to spiritual growth and finding meaning in illness. Session 2, titled <q>My Body,</q> covers topics related to breast changes, aches/pains, fatigue, and weight changes. Session 3, titled <q>My Mind and My Relationships,</q> covers topics related to anxiety, fear, and relationships with others.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, education sessions include a culturally-targeted cookbook and a guide to grocery shopping smart.</li> <li class="seamTextUnorderedListItem">For both groups, all sessions will take approximately one hour, and follow-up phone calls will last about 20 minutes.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05452681' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.komen.org/breast-cancer/survivorship/health-concerns/quality-of-life/#:~:text=Quality%20of%20life%20after%20treatment,even%20years%20after%20treatment%20ends.' target='_blank'>Susan G. Komen: Quality of Life After Breast Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cdc.gov/pcd/issues/2016/16_0096.htm' target='_blank'>Centers for Disease Control and Prevention: Quality of Life of Black Breast Cancer Survivors</a> </li></ul>
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25

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05409664

Physical Activity Intervention for Breast Cancer Survivors

Peer Coaching for Physical Activity Promotion Among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation Scientific Title

Purpose
To study whether moderate-to-vigorous physical activity (MVPA) counseling increases physical activity levels and improves quality of life of breast cancer survivors.
Who is this for?
Women with stage 0 (DCIS), stage I, stage II, or stage III breast cancer diagnosed in the last 5 years who have completed treatment. You must engage in less than 30-90 minutes of physical activity per week.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Moderate-to-vigorous physical activity (MVPA) counseling, weekly phone call with peer coach for 3 months</li> <li class="seamTextUnorderedListItem">Self-monitoring physical activity via Fitbit, daily for 3 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Self-monitoring physical activity via Fitbit, daily for 3 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">If you are in Group 1, you will work with a peer coach with the goal of gradually increasing your physical activity to at least 150 minutes of moderate-to-vigorous physical activity (MPVA) per week.</li> <li class="seamTextUnorderedListItem">If you are in Group 2, you will be asked to gradually increase your physical activity to at least 150 minutes of moderate-to-vigorous physical activity (MPVA) per week.</li> <li class="seamTextUnorderedListItem">The goal is to promote aerobic exercise that is safe and enjoyable, such as walking.</li> <li class="seamTextUnorderedListItem">A Fitbit is a device you wear on your wrist that tracks your physical activity.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05409664' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/exercise' target='_blank'>Breastcancer.org: Exercise</a> </li></ul>
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26

No Travel Required

VISITS: No visits required

PHASE: NA

NCT ID: NCT05087095

Telehealth CALM Therapy for People with Brain Metastasis and Depression or Anxiety

Managing Distress in Malignant Brain Cancer Scientific Title

Purpose
To study if telehealth CALM therapy decreases symptoms of depression or anxiety.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis) and experiencing depression or anxiety.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Telehealth CALM therapy, 6 sessions over 3 months</li> <li class="seamTextUnorderedListItem">3 questionnaires over 6 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">3 questionnaires over 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Managing Cancer and Living Meaningfully (CALM) therapy is designed to decrease symptoms of depression and anxiety for people with cancer.</li> <li class="seamTextUnorderedListItem">If you are in Group 1, you will receive CALM therapy virtually through telehealth.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05087095' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
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