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Find Breast Cancer Clinical Trials That Are Right For You

The clinical trials listed below are open in the U.S. for people with DCIS (stage 0), stage 1, stage 2, stage 3, or stage 4 (metastatic)
breast cancer. Clinical trials are available for people who are newly diagnosed with breast cancer, currently in treatment, experiencing
breast cancer recurrence, living with metastatic disease, as well as breast cancer survivors who have completed treatment.

Use the search box and filters to find a trial that’s right for you.


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(Last updated: December 03, 2022)

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Treatment

Brain Mets

BRCA1/2 (inherited)

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Hormone Therapy

Leptomeningeal Disease

Radiation Oncology

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Surgery: Reconstruction

Targeted Therapy: All

Targeted Therapy: Anti-HER2 Therapy

Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

Targeted Therapy: Other Targeted Therapy

Vaccines and Immunotherapy

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Complementary and Alternative Medicine

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AKT

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BARD1

BRCA1/2 (tumor)

BRIP1

CD205

CD70

CHEK2 or CHEK1

ESR1

FGFR

HER2/ERBB2

HLA

MET or C-Met

NTRK

PALB2

PIK3CA or PI3K

PTEN

RAD51

RAF (including BRAF)

RAS (KRAS or NRAS)

RB

ROS1

TP53

1

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 1 visit

PHASE: NA

NCT ID: NCT03012399

Effects of Hypnosis During Breast Cancer Surgery

Biobehavioral Effects of Hypnosis During Breast Cancer Surgery Scientific Title

Purpose
To study a relaxation method called hypnosedation.
Who is this for?
Women with DCIS or stage I breast cancer who have not yet had breast surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hypnosedation performed by a hypnotherapist, beginning right before surgery and continuing through until your surgery ends</li> <li class="seamTextUnorderedListItem">Conscious sedation during surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Empathetic conversation with a hypnotherapist right before surgery</li> <li class="seamTextUnorderedListItem">General anesthesia during surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Using hypnosedation before and during breast cancer surgery may allow patients to avoid having general anesthesia.</li> <li class="seamTextUnorderedListItem">Hypnosedation is administered by a hypnotherapist, a mind-body specialist who uses words and images to help you relax during surgery.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03012399' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://abcnews.go.com/Health/Healthday/story?id=4508455&page=1' target='_blank'>ABC News: Hypnosis Article</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/treatment/comp_med/types/hypnosis' target='_blank'>Breastcancer.org: Hypnosis</a> </li></ul>
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2

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT05198843

Dasatinib With Omega-3 Dietary Supplement for Metastatic Triple Negative Inflammatory Breast Cancer

Phase Ib/II Study of EPA-Based EphA2 Targeted Therapy for Patients With Metastatic Triple-Negative Inflammatory Breast Cancer Scientific Title

Purpose
To study the safety, best dose, effects (good and bad), and anti-cancer activity of dasatinib (Sprycel®), a targeted therapy called a tyrosine kinase inhibitor, with icosapent ethyl (Vascepa®), an omega-3 dietary supplement.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) inflammatory breast cancer (IBC) that has progressed on standard treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Icosapent ethyl (Vascepa®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®) is a type of targeted therapy called a tyrosine kinase inhibitor. Tyrosine kinase inhibitors work by blocking proteins that signal cancer cells to multiply, which may help keep cancer cells from growing.</li> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®) is approved for treatment of other cancers.</li> <li class="seamTextUnorderedListItem">Icosapent ethyl (Vascepa®) is an omega-3 fatty acid dietary supplement. It may decrease the amount of fats made in the liver and may reduce the growth of triple negative inflammatory breast cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05198843' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/types/inflammatory' target='_blank'>Breastcancer.org: Inflammatory Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/dasatinib' target='_blank'>Cancer Research UK: Dasatinib (Sprycel®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a613024.html' target='_blank'>MedlinePlus: Icosapent Ethyl (Vascepa®)</a> </li></ul>
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3

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 10-12 visits over 8 weeks

PHASE: II

NCT ID: NCT02754752

Acupuncture for Relieving Severe Post-Mastectomy Pain

Randomized-Controlled Trial of Acupuncture for Post-Mastectomy Pain Syndrome Scientific Title

Purpose
This study is investigating whether electro-acupuncture can help reduce pain women feel after their mastectomy.
Who is this for?
Women who had a mastectomy at least 4 months ago. You must have had persistent pain in your chest area for at least 3 months and have seen your oncologist within the last 6 months.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Acupuncture on specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Acupuncture on non-specific body points</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Wait-List</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">No acupuncture</li> <li class="seamTextUnorderedListItem">After 4 weeks, optional participation in up to 10 acupuncture sessions, over 4 weeks</li> <li class="seamTextUnorderedListItem">6 Questionnaires, over 8 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Electro-acupuncture is a two-step process. First, hair-thin needles are put into specific points in your body. Then, a mild electrical current is applied to the needles at a level that is comfortable to you.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02754752' target='_blank'>ClinicalTrials.gov</a> </li></ul>
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4

NEAREST SITE: 2352 miles
University of Rochester Medical Center
Rochester,NY

VISITS: At least 8 visits

PHASE: NA

NCT ID: NCT04230941

MAAT-G Workshops and Workbook to Improve Cognition for People Ages 65+ With Breast Cancer After Completing Treatment

Mitigating Cancer-Related Cognitive Impairment in Older Adults With Breast Cancer Receiving Chemotherapy: Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase I Scientific Title

Purpose
To study if the MAAT-G intervention can improve or maintain cognition for older adults after completing breast cancer treatment.
Who is this for?
People ages 65 or older with stage I, stage II, or stage III breast cancer who have completed standard treatment with chemotherapy and have mild cognitive problems.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MAAT-G intervention, 8 workshops and workbook</li> <li class="seamTextUnorderedListItem">Questionnaires</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for trial schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Memory and Attention Adaptation Training (MAAT) is a cognitive-behavioral therapy (CBT)-based intervention for cancer-related cognitive problems.</li> <li class="seamTextUnorderedListItem">MAAT is a series of workshops delivered by a psychologist via video-conferencing, supplemented by a workbook, which provides instruction and practice with behavioral coping skills, stress management techniques, and other support strategies. </li> <li class="seamTextUnorderedListItem">MAAT is used for younger cancer survivors, but needs to be adapted for older adults to address their unique needs. </li> <li class="seamTextUnorderedListItem">Memory and Attention Adaptation Training-Geriatrics (MAAT-G) is MAAT for people over the age of 65.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04230941' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20100913' target='_blank'>Breastcancer.org: Older Women More Likely to Have Chemo-Related Cognitive Problems</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/podcast/chemobrain-update' target='_blank'>Breastcancer.org (Podcast): Chemo Brain Update: Cancer-Related Cognitive Decline</a> </li></ul>
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5

NEAREST SITE: 2353 miles
University of Florida CTSI Clinical Research Center
Gainesville,FL

VISITS: Number of visits unavailable

PHASE: NA

NCT ID: NCT05473026

Gratitude Journaling and Goal Setting for Black Women with Breast Cancer and Breast Cancer Survivors

A Pilot Feasibility Study of a Gratitude Journaling Intervention to Enhance Well-being and Exercise Readiness in Older African American Female Breast Cancer Survivors Scientific Title

Purpose
To study the ability of gratitude journaling and goal setting to promote exercise and well-being.
Who is this for?
Black women with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who have received chemotherapy after surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gratitude journaling, daily for 2 months</li> <li class="seamTextUnorderedListItem">Goal setting, daily for 2 months</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">General journaling, daily for 2 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will receive a journal (paperback or electronic) and a daily journaling prompt depending on your group assignment.</li> <li class="seamTextUnorderedListItem">Goal setting will be based on the American Cancer Society's Nutrition, Physical Activity, and Cancer toolkit.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05473026' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/cancerwise/cultivating-gratitude-and-hope.h00-158905389.html' target='_blank'>MD Anderson Cancer Center: Gratitude During Cancer Treatment</a> </li><li class='seamTextUnorderedListItem'><a href='https://copingmag.com/gratitude-for-cancer-survivors/#:~:text=For%20cancer%20survivors%2C%20practicing%20gratitude,constantly%20about%20their%20cancer%20returning.' target='_blank'>Coping Magazine: Gratitude for Cancer Survivors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/healthy/eat-healthy-get-active/acs-guidelines-nutrition-physical-activity-cancer-prevention/guidelines.html' target='_blank'>American Cancer Society: Guideline for Diet and Physical Activity</a> </li></ul>
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6

NEAREST SITE: 2539 miles
Memoral Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT03988595

Exercise With Hormone Therapy for Metastatic HR+, HER2- Breast Cancer

Phase 1a/1b Trial of Exercise Treatment With Concurrent First-Line Therapy for Hormone Receptor Positive Metastatic Breast Cancer Scientific Title

Purpose
To study the effects (good and bad) and anti-cancer activity of exercise with hormone therapy.
Who is this for?
Women with stage IV (metastatic) hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer who are receiving or planning to receive their first hormone therapy for metastatic disease and engage in less than 1 hour of exercise per week.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will complete the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Walking, 1.5-6 hours per week for 6 months</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Exercise may delay the development of resistance to hormone therapy while slowing the growth of tumors.</li> <li class="seamTextUnorderedListItem">Exercise sessions will be remotely (online) monitored with TeleEx.</li> <li class="seamTextUnorderedListItem">You will also be given a device to track your daily general physical activity.</li> <li class="seamTextUnorderedListItem">Premenopausal and perimenopausal women will also be given a drug that will put women in temporary menopause.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03988595' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/managing-life/exercise' target='_blank'>Breastcancer.org: Exercise</a> </li></ul>
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7

NEAREST SITE: 2539 miles
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge,NJ

VISITS: At least 1 visit per month

PHASE: II

NCT ID: NCT05090358

Preventing High Blood Sugar in People with Metastatic ER+, HER2- Breast Cancer with a PIK3CA Mutation

Targeting Insulin Feedback to Enhance Alpelisib (TIFA): A Phase 2 Randomized Control Trial in Metastatic PIK3CA-mutant Hormone-Receptor Positive Breast Cancer Scientific Title

Purpose
To determine if a ketogenic or low carbohydrate diet with canagliflozin (Invokana®), a high blood pressure drug, or canagliflozin (Invokana®) alone can prevent high blood sugar.
Who is this for?
Post-menopausal women and men with metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer with a PIK3CA mutation who have not received chemotherapy or more than 1 line of hormone therapy.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ketogenic diet</li> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®), by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), injection, every 2 weeks for 1 month, then monthly</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Low carbohydrate diet</li> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®), by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), injection, every 2 weeks for 1 month, then monthly</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®), by mouth</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), injection, every 2 weeks for 1 month, then monthly</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The ketogenic diet consists of low carbohydrates and high fat.</li> <li class="seamTextUnorderedListItem">Canagliflozin (Invokana®) is a drug approved for treating high blood sugar for people with type 2 diabetes. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a type of hormone therapy called a selective estrogen receptor degrader (SERD).</li> <li class="seamTextUnorderedListItem">SERDs work by binding to and breaking down estrogen receptors.</li> <li class="seamTextUnorderedListItem">Alpelisib (Piqray®) is a type of targeted therapy called a PI3K inhibitor.</li> <li class="seamTextUnorderedListItem">If there is a mutation in the PIK3CA gene, the PI3K pathway can become overactivated, which allows cancer cells to grow. PI3K inhibitors block the PI3K pathway.</li> <li class="seamTextUnorderedListItem">Targets or mutations: PIK3CA</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05090358' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://osher.ucsf.edu/patient-care/integrative-medicine-resources/cancer-and-nutrition/faq/low-carbohydrate-diet' target='_blank'>UCSF Osher Center for Integrative Health: Low Carbohydrate Diet and Ketogenic Diet</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.healthline.com/nutrition/low-carb-vs-keto' target='_blank'>Healthline: Low Carbohydrate Diet and Ketogenic Diet</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.invokana.com/' target='_blank'>Janssen Drug Information Page: Canagliflozin (Invokana®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/faslodex' target='_blank'>Breastcancer.org: Fulvestrant (Faslodex®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted-therapy/piqray' target='_blank'>Breastcancer.org: Alpelisib (Piqray®)</a> </li></ul>
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8

NEAREST SITE: 2693 miles
Massachusetts General Hospital
Boston,MA

VISITS: Number of visits unavailable, before surgery

PHASE: I

NCT ID: NCT03596073

Topical Ointment Calcipotriene Before Surgery to Stimulate Immune Cells

A Pilot Trial of Topical Calcipotriene Treatment for Breast Cancer Immunoprevention Scientific Title

Purpose
To see the effect that a topical ointment called calcipotriene has on the tumor's microenvironment.
Who is this for?
People who are 45 or older, scheduled to have breast cancer surgery, and not receiving chemotherapy before surgery.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Topical calcipotriene ointment, 2 times per day, for the period between biopsy and surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Topical vaseline, 2 times per day, for the period between core biopsy and surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Calcipotriene is a man-made form of vitamin D.</li> <li class="seamTextUnorderedListItem">It is approved by the FDA to treat psoriasis. Its use in breast cancer is experimental. </li> <li class="seamTextUnorderedListItem">Giving the treatment before surgery allows researchers to look at how it affects the tumor's microenvironment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03596073' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-1506/calcipotriene-topical/details' target='_blank'>WebMD: Calcipotriene</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/1672178' target='_blank'>Pubmed: Topical calcipotriol treatment in advanced breast cancer</a> </li></ul>
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