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(Last updated: December 03, 2021)

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NEAREST SITE: 657 miles
Honor Health Research Institute
Scottsdale,AZ

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04691375

PY314 Alone or with Pembrolizumab in Metastatic HER2- Breast Cancer

A Phase 1a/1b Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PY314 as a Single Agent and In Combination With Pembrolizumab in Subjects With Advanced Solid Tumors Scientific Title

Purpose
To determine the best dose, safety, and effects (good and bad) of PY314, an experimental targeted therapy, given alone or with Pembrolizumab (Keytruda®).
Who is this for?
People with metastatic (stage IV) HER2 negative (HER2-) breast cancer who have received at least one treatment for metastatic disease.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PY314</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PY314</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PY314 is an experimental drug that targets TREM2, a protein found on some tumor cells. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. Blocking PD-1 may allow the body's immune system to detect and fight cancer cells.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04691375' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.prnewswire.com/news-releases/pionyr-immunotherapeutics-initiates-phase-1-clinical-study-of-py314-301175564.html' target='_blank'>Press Release: PY314</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pionyrtx.com/pipeline/py314/' target='_blank'>Pionyr Immunotherapeutics: PY314</a> </li></ul>
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