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(Last updated: October 14, 2021)

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NEAREST SITE: 1856 miles
Northwestern University
Chicago,IL

VISITS: 1 visit every month, ongoing

PHASE: I

NCT ID: NCT04514484

Targeted Therapy and Immunotherapy for Advanced Triple Negative Breast Cancer and HIV

Pilot Trial of Nivolumab Plus Cabozantinib for Advanced Solid Tumors in Patients With HIV Infection Scientific Title

Purpose
To study the safety, side effects, and anti-cancer activity of giving the targeted therapy cabozantinib (Cabometyx®) with the immunotherapy nivolumab (Opdivo®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer who are receiving treatment for HIV.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cabozantinib (Cabometyx®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, once a month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cabozantinib ( Cabometyx®) is a targeted therapy that blocks some of molecules (c-Met, VEGFR2, AXL and RET.) that cells need to grow. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®) is a type of immunotherapy called a PD-1 inhibitor. By blocking PD-1, it helps the immune system see and kill cancer cells. It is approved to treat certain types of cancer. Its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">HIV (human immunodeficiency virus) is a virus that attacks the body's immune system. HIV can affect the outcome of cancer treatment.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04514484' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2020-05956&r=1' target='_blank'>National Cancer Institute: Study Website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/cabozantinib-s-malate' target='_blank'>NCI Drug Dictionary: Cabozantinib (Cabometyx®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/drugs/nivolumab' target='_blank'>NCI Drug Dictionary: Nivolumab</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cabometyx.com/?gclid=Cj0KCQiAyJOBBhDCARIsAJG2h5csfcndMVfIxEH_77I0NfOF7sZ2p4uEvWyys27Gaj9s6e7c7nXm3rMaArkeEALw_wcB' target='_blank'>Exelixis Drug Information Page: Cabometyx® (Cabozantinib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancertodaymag.org/Pages/cancer-talk/HIV-Can-Worsen-Cancer-Treatment-Outcomes.aspx' target='_blank'>Cancer Today: HIV Can Worsen Cancer Treatment Outcomes</a> </li></ul>
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