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(Last updated: February 27, 2021)

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1

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: 1 visit every 3 weeks

PHASE: II

NCT ID: NCT04504916

Experimental Antibody-Drug Conjugate VLS-101 for Metastatic Breast Cancer

A Phase 2 Study of VLS-101 in Patients With Solid Tumors Scientific Title

Purpose
To study the safety, side effects and anti-cancer activity of the experimental antibody-drug conjugate (ADC) VLS-101.
Who is this for?
People with metastatic (stage IV) breast cancer who have already received at least one therapy for metastatic disease.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">VLS-101, by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">VLS-101 is a type of therapy called an antibody-drug conjugate (ADC). </li> <li class="seamTextUnorderedListItem">An antibody-drug conjugate (ADC) is a type of therapy that combines an antibody that targets cancer cells with a therapy that can kill cancer cells.</li> <li class="seamTextUnorderedListItem">Because the antibody only targets cancer cells, the ADC does not kill normal cells, making it less likely to cause side effects.</li> <li class="seamTextUnorderedListItem">The VLS-101 antibody targets ROR1, a protein that is expressed by breast cancer cells but not healthy cells, and it delivers the anti-cancer therapy monomethyl auristatin E. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04504916' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/research-news/antibody-drug-conjugates/' target='_blank'>Metastatic Trial Talk: Getting to the Target, Antibody Drug Conjugates</a> </li><li class='seamTextUnorderedListItem'><a href='https://ashpublications.org/blood/article/134/Supplement_1/2856/423547/Vls-101-Is-a-Novel-Therapeutic-Antibody-Drug' target='_blank'>American Society of Hematology: VLS-101</a> </li></ul>
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