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(Last updated: September 27, 2020)

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1

NEAREST SITE: 273 miles
Sansum Clinic
Santa Barbara,CA

VISITS: 3 visits over 3 months

PHASE: NA

NCT ID: NCT04436120

Next Generation Sequencing for Advanced HER2- Breast Cancer After Disease Progression

TREATMENT RESISTANCE FOLLOWING ANTI-CANCER THERAPIES (TRANSLATE) Scientific Title

Purpose
To compare the genetics of your cancer before and after you receive a targeted therapy to study why your cancer stopped responding to treatment and to help you decide which therapy or clinical trial you should try next.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-), hormone positive (ER+ and/or PR+) breast cancer or HER2 negative (HER2-) breast cancer with an inherited BRCA 1 or BRCA 2 mutation. Your cancer must have progressed while receiving palbociclib (Ibrance®) or a PARP inhibitor.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy (tissue sample) of your tumor</li> <li class="seamTextUnorderedListItem">Blood draw</li> <li class="seamTextUnorderedListItem">Results of the Next Generation Sequencing (gene panel tests of your tumor and blood)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Next Generation Sequencing (NGS) is gene panel testing of your blood and tumor. </li> <li class="seamTextUnorderedListItem">NGS is a type of comprehensive genomic testing. Genomic testing looks at genetic mutations within your tumor.</li> <li class="seamTextUnorderedListItem">This information may help you and your doctor decide which therapy or clinical trial is right for you. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04436120' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pfizer.com/science/find-a-trial/nct04436120' target='_blank'>Pfizer Clinical Trial Information Page</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/testing/types/broad-molecular-profiling-tests' target='_blank'>Breastcancer.org: Broad Molecular Profiling Tests</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.medscape.com/viewarticle/899785' target='_blank'>Medscape: Should Every Metastatic Breast Cancer Patient Undergo Next-Generation Sequencing?</a> </li></ul>
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