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(Last updated: October 21, 2020)

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NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Weekly visits

PHASE: I

NCT ID: NCT04429542

BCA101 for Metastatic Triple Negative Breast Cancer That Tests Positive for EGFR

First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFβ Fusion Protein BCA101 Alone and in Combination With Pembrolizumab in Patients With EGFR-Driven Advanced Solid Tumors Scientific Title

Purpose
To study the safety, anti-cancer activity, and effects (good and bad) of the targeted therapy BCA101.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer that tests positive for EGFR amplification and who have no other treatment options available.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BCA101, by IV, once a week, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">BCA101 targets the EGFR and TGFβ pathways. </li> <li class="seamTextUnorderedListItem">It is an experimental targeted therapy, this means it is only available in clinical trials.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of metastatic cancer. </li> <li class="seamTextUnorderedListItem">Targets or mutations: EGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04429542' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://tnbcfoundation.org' target='_blank'>Triple Negative Breast Cancer Foundation</a> </li><li class='seamTextUnorderedListItem'><a href='https://europepmc.org/article/med/27648353' target='_blank'>Journal Article Abstract: A Perspective on Anti-EGFR Therapies Targeting Triple Negative Breast Cancer.</a> </li></ul>
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