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(Last updated: October 21, 2020)

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NEAREST SITE: 353 miles
City of Hope
Duarte,CA

VISITS: Number of visits unavailable

PHASE: I

NCT ID: NCT04348916

ONCR-177 Alone or With Pembrolizumab in Advanced Breast Cancer

A Phase 1, Open-Label, Multicenter, Dose Escalation and Expansion Study of ONCR-177, an Oncolytic Herpes Simplex Virus for Intratumoral Injection, Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors Scientific Title

Purpose
To study the best dose and anti-cancer activity of giving the genetically modified virus ONCR-177 alone and in combination with the immunotherapy pembrolizumab (Keytruda®).
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer who have no standard treatment options available.    Full eligibility criteria
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  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONCR-177, by injection, directly into your tumor</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONCR-177, by injection, directly into your tumor</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ONCR-177 is an Oncolytic Herpes Simplex Virus--this is a herpes virus that has been genetically modified to destroy cancer cells. Researchers believe it will also work as an immunotherapy.</li> <li class="seamTextUnorderedListItem">ONCR-177 is injected directly into the tumor. </li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is a type of immunotherapy called a PD-1 inhibitor. It gets the immune system to go after cancer cells.</li> <li class="seamTextUnorderedListItem">Pembrolizumab (Keytruda®) is approved to treat only certain types of breast cancer and its use in this trial is considered experimental. </li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of advanced cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04348916' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://static1.squarespace.com/static/59df87cbd7bdceb69ad86d5a/t/5ca4c245e5e5f0302a360460/1554301532888/Design+of+ONCR-177+base+vector.pdf' target='_blank'>Drug Company Information Page: ONCR-177</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Oncolytic_herpes_virus' target='_blank'>Wikipedia: Oncolytic Herpes Virus</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.keytruda.com' target='_blank'>Merck Oncology Information Page: Keytruda® (Pembrolizumab)</a> </li></ul>
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