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(Last updated: October 21, 2020)

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1

NEAREST SITE: 1643 miles
MD Anderson Cancer Center
Houston,TX

VISITS: Hospital stay may be required

PHASE: I

NCT ID: NCT04319757

Immunotherapy ACE1702 for Advanced HER2 Expressing (HER2 IHC 2+ or 3+) Breast Cancer

A Phase I, Open Label, Dose Escalation Study of ACE1702 Cell Immunotherapy in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors Scientific Title

Purpose
To study the safety, anti-cancer activity, and effects (good and bad) of an experimental natural killer (NK) cell immunotherapy that targets HER2-expressing cancer cells.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) HER2-expressing (HER2 IHC 2+ or 3+) breast cancer.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®) and fludarabine (Fludara®), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">followed by:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ACE1702 natural killer cell immunotherapy (anti-HER2 oNK cells), by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule. Hospital stay may be required.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ACE1702 is the natural killer (NK) cell immunotherapy used in this trial. </li> <li class="seamTextUnorderedListItem">Before you receive ACE1702, you will be given the chemotherapy drugs fludarabine and cyclophosphamide. These drugs are used to prepare your immune system to receive the NK immunotherapy.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04319757' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.acepodia.com/pipeline' target='_blank'>Acepodia Drug Information Page: ACE1702</a> </li><li class='seamTextUnorderedListItem'><a href='https://en.wikipedia.org/wiki/Natural_killer_cell' target='_blank'>Wikipedia: Natural Killer Cell</a> </li></ul>
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