Home   HELP  /   AYUDA  /   求助 : help-desk@bctrials.org  /   (415) 476-5777 Click to print page  Print

Browse Trials

In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. Use the contact information in our trial listings to call or email the research site for information about a trial's status.

Visit COVID-19 & Cancer Clinical Trials on Metastatic Trial Talk for regularly updated information about clinical trials during the coronavirus pandemic.

Currently viewing trials
(Last updated: August 03, 2020)

Zip Code:

Narrow my choices:

Radius (miles): All U.S.

20 All U.S.
Early stage    Advanced 
Treatment    Non-treatment 
Phase    I     II     III 
Display Only New Trials 



Hormone Therapy

Radiation Oncology


Surgery: Reconstruction

Targeted Therapy: All

Targeted Therapy: Anti-HER2 Therapy

Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

Targeted Therapy: Other Targeted Therapy

Vaccines and Immunotherapy

Other Treatment



Complementary and Alternative Medicine

Decision Support

Diagnosing Breast Cancer

Genetics/Family History

Having Children


Managing Side Effects

No Travel Required

Predicting Response to Treatment

Preventing Breast Cancer

Preventing Recurrence





NEAREST SITE: 2432 miles
National Institutes of Health Clinical Center

VISITS: Hospital stay for 4-5 weeks


NCT ID: NCT04102436

CAR T-Cell Immunotherapy for Metastatic Breast Cancer

A Phase II Study Using the Administration of Autologous T-Cells Engineered Using the Sleeping Beauty Transposon/Transposase System to Express T-Cell Receptors Reactive Against Mutated Neoantigens in Patients With Metastatic Cancer Scientific Title

To study if an immunotherapy, made from your own white blood cells that are then modified with T-cell receptors, can cause breast cancer tumors to shrink.
Who is this for?
People with metastatic breast cancer that did not respond to the first treatment received.    Full eligibility criteria
Contact research site

Contact Research Sites

  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be in the hospital and receive the following: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Before hospital stay:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Blood draw for the collection of cells (leukapheresis)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Hospital stay for receiving treatment (4-5 weeks):</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Modified white blood cells (CAR T-cell immunotherapy), by IV</li> <li class="seamTextUnorderedListItem">Cyclophosphamide (Cytoxan®) and Fludarabine (Fludara®), by IV</li> <li class="seamTextUnorderedListItem">Aldesleukin, by IV, once every 8 hours, for up to 10 doses</li> <li class="seamTextUnorderedListItem">Antibiotics</li> <li class="seamTextUnorderedListItem">Filgrastim, by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">After hospital stay:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visits approximately 6 and 12 weeks after treatment, then every 3-6 months for 3 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">T-cells can be modified in a lab to recognize certain changes in the tumor. </li> <li class="seamTextUnorderedListItem">To create the personalized T cells, your white blood cells will be collected and modified in ways that will help them go after your tumor cells. </li> <li class="seamTextUnorderedListItem">These supercharged T cells will then be put into your body. This will be done in the hospital. </li> <li class="seamTextUnorderedListItem">This type of therapy is called CAR T-cell therapy. </li> <li class="seamTextUnorderedListItem">Before you receive the enhanced T cells, you will be treated with the chemotherapy drugs cyclophosphamide (Cytoxan®) and fludarabine (Fludara®). This is to prepare your body to receive the enhanced T cells. </li> <li class="seamTextUnorderedListItem">You will also receive aldesleukin, a drug that enhances immune function and filgrastim, to reduce your risk of developing an infection. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of metastatic cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04102436' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/about-cancer/treatment/research/car-t-cells' target='_blank'>NCI Research Article: CAR T Cells, Engineering Patients’ Immune Cells to Treat Their Cancers</a> </li></ul>
See more