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(Last updated: May 21, 2020)

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1

NEAREST SITE: 533 miles
OHSU Knight Cancer Institute
Portland,OR

VISITS: Number of visits varies based upon assigned treatment

PHASE: I

NCT ID: NCT03878524

A Personalized Medicine Study for Patients With Metastatic Breast Cancer (SMMART, Basket Study)

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) Trial Scientific Title

Purpose
To assess the safety and feasibility of having a tumor board select therapy combinations for each individual patient.
Who is this for?
People with metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • <p class="seamTextPara"> You will undergo the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Biopsy</li> <li class="seamTextUnorderedListItem">Your tumor sample will be tested to identify biomarkers</li> <li class="seamTextUnorderedListItem">You will be assigned to a specific treatment group with a combination of two drugs selected from 35 drugs</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">You may repeat this process if you disease progresses or if you could not tolerate the assigned treatment.</i> </p> <p class="seamTextPara"> <i class="seamTextEmphasis">These 35 drugs are: Abiraterone, Enzalutamide, Venetoclax, Palbociclib, All-Trans Retinoic Acid, Bortezomib, Cabazitaxel, Oxaliplatin, Fluorouracil, Folinic Acid, Carboplatin, Panobinostat, Vorinostat, Pembrolizumab, Bevacizumab, Ipilimumab, Nivolumab, Everolimus, Sirolimus, Celecoxib, Olaparib, Afatinib, Cabozantinib, Sorafenib, Dasatinib, Erlotinib, Idelalisib, Imatinib, Lenvatinib, Pertuzumab, Ponatinib, Ruxolitinib, Sunitinib, Trametinib, Vemurafenib </i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The tumor board will make a personalized treatment decision by evaluating the tumor's genetic profile. </li> <li class="seamTextUnorderedListItem">The board will choose among 35 types of targeted therapy, immunotherapy, or chemotherapy. </li> <li class="seamTextUnorderedListItem">This study also is enrolling patients with other types of cancer. </li> <li class="seamTextUnorderedListItem">This type of study is called a basket trial.</li> <li class="seamTextUnorderedListItem">Targets or mutations: ABL, BCL2, BRAF, CDK4, CDK6, COX-2, CSF-1R, CTLA-4, EGF, EGFR, FGFR, FLT3, HDAC, HER2, JAK1/2, KIT, MEK, MET, mTOR, PARP, PD-1, PDGFR, PI3Kdelta, RAF, RET, VEGF, VEGF ligand, VEGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03878524' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ohsu.edu/spatial-systems-biomedicine-center/serial-measurements-molecular-and-architectural-responses' target='_blank'>Oregon Health & Science University: SMMART program</a> </li><li class='seamTextUnorderedListItem'><a href='https://news.ohsu.edu/2018/11/16/making-cancer-clinical-trials-smmart' target='_blank'>Oregon Health & Science University NEWS: Making cancer clinical trials SMMART</a> </li></ul>
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