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(Last updated: October 24, 2020)

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1

NEAREST SITE: 2314 miles
Wake Forest University Health Sciences
Winston-Salem,NC

VISITS: Coincides with standard surgery

PHASE: NA

NCT ID: NCT03796273

Ketoconazole Before Surgery For Breast Cancer Brain Metastases

tGLI1 as a Therapeutic Target in Brain Metastases: A Window of Opportunity Study Scientific Title

Purpose
To study the anti-cancer activity, safety, and effects (good and bad) of the anti-fungal drug ketoconazole when it is given before surgery.
Who is this for?
People with metastatic (stage IV) breast cancer that has spread to the brain.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ketoconazole, by mouth, once daily, for 4 days before surgery</li> <li class="seamTextUnorderedListItem">Surgery</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Standard of care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Surgery</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ketoconazole is an antifungal drug that may be able to block a protein called tGLI1. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of brain tumors.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03796273' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ketoconazole' target='_blank'>NCI Drug Dictionary: Ketoconazole</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/symptoms/types/recur_metast/treat_metast/options/local/brain' target='_blank'>Breastcancer.org: Brain Metastasis Local Treatments</a> </li></ul>
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