Home   HELP  /   AYUDA  /   求助 : help-desk@bctrials.org  /   (415) 476-5777 Click to print page  Print

Browse Trials

In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. Use the contact information in our trial listings to call or email the research site for information about a trial's status.

Visit COVID-19 & Cancer Clinical Trials on Metastatic Trial Talk for regularly updated information about clinical trials during the coronavirus pandemic.

Currently viewing trials
(Last updated: May 21, 2020)

Zip Code:

Narrow my choices:

Radius (miles): All U.S.

20 All U.S.
Early stage    Advanced 
Treatment    Non-treatment 
Phase    I     II     III 
Display Only New Trials 



Hormone Therapy

Radiation Oncology


Surgery: Reconstruction

Targeted Therapy: All

Targeted Therapy: Anti-HER2 Therapy

Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

Targeted Therapy: Other Targeted Therapy

Vaccines and Immunotherapy

Other Treatment



Complementary and Alternative Medicine

Decision Support

Diagnosing Breast Cancer

Genetics/Family History

Having Children


Managing Side Effects

No Travel Required

Predicting Response to Treatment

Preventing Breast Cancer

Preventing Recurrence





NEAREST SITE: 1643 miles
M D Anderson Cancer Center

VISITS: Number of visits unavailable


NCT ID: NCT03774472

Hydroxychloroquin, Palbociclib & Letrozole for ER+ HER2- Breast Cancer

Phase I/II Safety and Efficacy Study of Autophagy Inhibition With Hydroxychloroquine to Augment the Antiproliferative and Biological Effects of Pre-Operative Palbociclib Plus Letrozole for Estrogen Receptor-Positive and HER2-Negative Breast Cancer Scientific Title

To study the safety, best dose and effects (good and bad) of giving hydroxychloroquine along with palbociclib (Ibrance®) and letrozole (Femara®).
Who is this for?
Postmenopausal women with HR positive and HER2 negative breast cancer who has not yet had surgery (if you have stage I, II, or III breast cancer) and has not been treated with a CDK 4/6 inhibitor (if you have metastatic (stage IV) breast cancer).    Full eligibility criteria
Contact research site

Contact Research Sites

  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following treatment by mouth, daily for 1 year: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hydroxychloroquine</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®)</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Participants with early stage (stage I-III) breast cancer will undergo standard surgery after 1 or 5-6 months.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Hydroxychloroquine is a drug that decreases immune responses in the body. It is routinely used to prevent or to treat malaria and some auto-immune diseases. </li> <li class="seamTextUnorderedListItem">Ibrance is a targeted drug that is given along with hormone therapy to treat metastatic breast cancer in postmenopausal women. </li> <li class="seamTextUnorderedListItem">Femara is an aromatase inhibitor used to treat early-stage and metastatic breast cancer in postmenopausal women. It is approved for use along with Ibrance.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03774472' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-5482/hydroxychloroquine-oral/details' target='_blank'>WebMD: Hydroxychloroquine</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718030/' target='_blank'>NCBI: Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents</a> </li></ul>
See more