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(Last updated: November 13, 2019)

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1

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: 3 visits every month, ongoing

PHASE: I

NCT ID: NCT03725436

ALRN-6924 and Paclitaxel for Advanced Breast Cancer

A Phase 1b Study of ALRN-6924 in Combination With Paclitaxel in Wild-Type TP53 Advanced or Metastatic Solid Tumors Including Estrogen-Receptor Positive Breast Cancer Scientific Title

Purpose
To determine the safety and best dose of ALRN-6924 to use in combination with paclitaxel.
Who is this for?
Women and men with advanced (some stage III) or metastatic (stage IV) breast cancer and have no standard treatment options.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ALRN-6924, by IV, weekly, for 3 weeks out of every month</li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®), by IV, weekly, for 3 weeks out of every month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">ALRN-6924 is a new type of anti-cancer drug that targets MDM2/MDM4, inhibitors of a tumor suppressor protein called p53. </li> <li class="seamTextUnorderedListItem">Paclitaxel (Taxol®) is a chemotherapy drug used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of advanced cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03725436' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.aileronrx.com/pipeline/' target='_blank'>Sponsor site: ALRN-6924</a> </li></ul>
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