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(Last updated: September 27, 2020)

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1

NEAREST SITE: 1494 miles
The University of Kansas Cancer Center, West Clinic
Kansas City,KS

VISITS: 1 visit every 3 weeks, ongoing

PHASE: I-II

NCT ID: NCT03709082

Palbociclib, Letrozole and T-DM1 in ER Positive and HER2 Positive Metastatic Breast Cancer

A Phase I/II Study of Palbociclib, Letrozole and T-DM1 in Trastuzumab Refractory Estrogen Receptor Positive (ER+) and HER2 Positive Metastatic Breast Cancer Scientific Title

Purpose
To determine the best dose of palbociclib (Ibrance®) to use when it is given along with letrozole (Femara®) and T-DM1 (Kadcyla®).
Who is this for?
Women with ER positive and HER2 positive metastatic (stage IV) breast cancer and have been treated with a taxane and trastuzumab (Herceptin®).    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, once daily</li> <li class="seamTextUnorderedListItem">Letrozole (Femara®), by mouth, once daily</li> <li class="seamTextUnorderedListItem">T-DM1(Kadcyla®), by IV, once every 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Ibrance is a type of targeted therapy called a CDK 4/6 inhibitor. It is used along with certain hormonal therapies to treat ER positive and HER2 negative metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Femara is an aromatase inhibitor used to treat hormone-sensitive tumors in postmenopausal women. </li> <li class="seamTextUnorderedListItem">Kadcyla is used to treat HER2-positive metastatic breast cancer. It combines the chemotherapy drug DM1 with the HER2-targeted drug trastuzumab (Herceptin®).</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03709082' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pfizeroncologytogether.com/patient/ibrance/patient-financial-assistance?source=google&HBX_PK=s_ibrance&skwid=43700026569998730&cmp=353c6806-b5f2-46a9-afb6-d8080bcdf84d' target='_blank'>pfizer Oncology: Ibrance</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-4297/letrozole-oral/details' target='_blank'>WebMD: Letrozole</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/research-news/20131001' target='_blank'>Breastcancer.org: Kadcyla</a> </li></ul>
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