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(Last updated: October 21, 2020)

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NEAREST SITE: 2133 miles
John B. Amos Cancer Center
Columbus,GA

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT03691493

Radiation Therapy, Palbociclib & Hormone Therapy for Breast Cancer Related Bone Metastases

A Phase II Multi-Institutional Study of Concurrent Radiotherapy, Palbociclib, and Hormone Therapy for Treatment of Bone Metastasis in Breast Cancer Patients Scientific Title

Purpose
To study the effects (good and bad) of using radiation therapy along with the targeted therapy palbociclib (Ibrance®) and hormone therapy.
Who is this for?
People with metastatic (stage IV) hormone positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer that has spread to the bone.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy, daily, for 5-10 days</li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, daily, for 3 out of every 4 weeks</li> <li class="seamTextUnorderedListItem">Your doctor's choice of hormone therapy: letrozole, anastrozole, exemestane, tamoxifen, or fulvestrant</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. </li> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a type of targeted therapy called a CDK 4/6 inhibitor. It is used along with a hormone therapy to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">The hormone therapies used along with Ibrance are fulvestrant (Faslodex®), letrozole (Femara®), anastrozole (Arimidex®), exemestane (Aromasin®) and tamoxifen.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03691493' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/79/4_Supplement/PD8-12' target='_blank'>AACR Cancer Research Abstract: Safety and efficacy of palbociclib and radiotherapy in MBC</a> </li></ul>
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