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(Last updated: August 03, 2020)

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NCT ID: NCT03409458

PT-112 plus Avelumab for Advanced Breast Cancer

A Phase 1b/2a Dose Escalation and Confirmation Study of PT-112 in Advanced Solid Tumors in Combination With Avelumab Scientific Title

To compare the safety and effects (good and bad) of using the experimental drug PT-112 and the immunotherapy drug avelumab (Bavencio®) to treat metastatic breast cancer.
Who is this for?
People with metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PT-112, by IV </li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PT-112 is an experimental drug that works like both a chemotherapy and an immunotherapy. </li> <li class="seamTextUnorderedListItem">Avelumab (Bavencio®) is a type of immunotherapy drug called a PD-L1 inhibitor. It is currently approved to treat Merkel cell and bladder cancer and its use in breast cancer is considered experimental.</li> <li class="seamTextUnorderedListItem">Patients with metastatic breast cancer are eligible for only the phase I (dose-finding) part of this study.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03409458' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.2519' target='_blank'>Journal of Clinical Oncology: A phase I study of PT-112 in advanced solid tumors</a> </li><li class='seamTextUnorderedListItem'><a href='http://phosplatin.com/about/' target='_blank'>Phosplatin Therapeutics: A New Generation of Cancer Therapies</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.uh.edu/nsm/chemistry/news-events/stories/2014/1023-cancer-drug.php' target='_blank'>University of Houston: Clinical Trials of Anti-Cancer Drug PT-112 Begin in U.S.</a> </li></ul>
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