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(Last updated: May 21, 2020)

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NEAREST SITE: 2567 miles
Memorioal Sloan Kettering Cancer Center
New York,NY

VISITS: Visits weekly for 3 weeks, then once a month thereafter, ongoing


NCT ID: NCT03344536

Debio 1347 plus Faslodex for HR+ Metastatic Breast Cancer

A Phase Ib/II Study of Debio 1347 Plus Fulvestrant in Patients With FGFR-Amplified Endocrine Receptor Positive Metastatic Breast Cancer Scientific Title

To investigate the safety and effect (good and bad) of using an experimental targeted therapy called Debio 1347 along with Faslodex to treat HR+ metastatic breast cancer.
Who is this for?
Women with estrogen receptor positive metastatic (stage IV) breast cancer whose tumor tests positive for FGFR (fibroblast growth factor receptor).    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Debio 1347, by mouth, daily, ongoing </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, weekly for 3 weeks, then once a month thereafter</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">If you are premenopausal, you will also receive goserelin (Zoladex®)</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Debio 1347 works by targeting the FGFR protein. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a hormone therapy used to treat hormone-sensitive metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">If you are premenopausal, you will also be treated with goserelin (Zoladex®).</li> <li class="seamTextUnorderedListItem">Targets or mutations: FGFR</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03344536' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.2500' target='_blank'>Journal of Clinical Oncology: Debio 1347</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal/erds/faslodex' target='_blank'>Breastcancer.org: Faslodex</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fgfr-inhibitor-debio-1347' target='_blank'>NCI Drug Dictionary: Debio 1347</a> </li></ul>
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