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(Last updated: November 13, 2019)

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NEAREST SITE: 1946 miles
IU Simon Cancer Center

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NCT ID: NCT03343613

LY3381916 Alone or With LY3300054 in Metastatic Breast Cancer

A Phase 1a/1b Study of an Anti-IDO-1 Agent (LY3381916) Administered Alone or in Combination With Anti- PD-L1 Checkpoint Antibody (LY3300054) in Solid Tumors Scientific Title

To evaluate the safety, best dose, and effects (good and bad) of LY3381916 when it is given alone or with LY3300054.
Who is this for?
Group 1: Women and men with metastatic (stage IV) breast cancer; Group 2: Women and men with metastatic triple negative (ER-, PR- and HER2-) breast cancer.    Full eligibility criteria
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  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3381916, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">LY3381916, by mouth</li> <li class="seamTextUnorderedListItem">LY3300054, by IV</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule.</i></p>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The immunotherapy LY3381916 gets immune cells to go after cancer cells by targeting the enzyme IDO-1. </li> <li class="seamTextUnorderedListItem">The immunotherapy LY3300054 is a PD-L1 checkpoint inhibitor. It blocks a protein called PD-L1 that stops the immune system from attacking the cancer cells. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancer. Both of these immunotherapies are investigational drugs.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03343613' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/794987' target='_blank'>NCI Drug Dictionary: IDO-1 inhibitor LY3381916</a> </li><li class='seamTextUnorderedListItem'><a href='http://cancerres.aacrjournals.org/content/78/13_Supplement/CT018' target='_blank'>Cancer Research: Safety and clinical activity of a novel anti-PD-L1 antibody (LY3300054)</a> </li></ul>
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