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In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. Use the contact information in our trial listings to call or email the research site for information about a trial's status.

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(Last updated: May 21, 2020)

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NEAREST SITE: 1946 miles
IU Simon Cancer Center

VISITS: Weekly visits, ongoing


NCT ID: NCT03243331

Gedatolisib plus PTK7-ADC for Metastatic Triple Negative Breast Cancer

An Initial Safety Study of Gedatolisib Plus PTK7-ADC for Metastatic Triple-negative Breast Cancer Scientific Title

To investigate the safety and effects (good and bad) of using two investigational drugs to treat metastatic triple negative breast cancer.
Who is this for?
People with metastatic (stage IV) breast cancer that is triple negative. You must have received at least 1 prior chemotherapy regimen for metastatic disease.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Gedatolisib, by IV, weekly (3 weeks on, 1 week off), ongoing </li> <li class="seamTextUnorderedListItem">PTK7-ADC (PF-06647020), by IV, every 3 weeks, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The two drugs are gedatolisib and PTK7-ADC. </li> <li class="seamTextUnorderedListItem">Gedatolisib is a targeted therapy that works by blocking PI3K and mTOR kinase proteins, which play a role in the cellular pathways that help tumors grow. </li> <li class="seamTextUnorderedListItem">PTK7-ADC (PF-06647020) targets a protein called PTK7, which is often found on cancer cells. </li> <li class="seamTextUnorderedListItem">It is an antibody-drug conjugate (ADC). This means it uses an antibody that targets cancer cells to deliver a drug that can kill these cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03243331' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.pfizer.com/files/news/asco/Pfizer_IO_GetaPI3KFactSheet.pdf' target='_blank'>Pfizer: Gedatolisib</a> </li></ul>
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