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(Last updated: November 13, 2019)

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1

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Monthly visits, ongoing

PHASE: I

NCT ID: NCT03218826

AZD8186 and Docetaxel for Advanced Breast Cancer with PTEN or PIK3C-beta Mutations

A Phase I Study of AZD8186 in Combination With Docetaxel in Patients With PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to Docetaxel Scientific Title

Purpose
To determine the best dose and effects (good and bad) of the targeted therapy AZD8186 when it is used with a chemotherapy to treat tumors that test positive for PTEN or PIK3C-beta mutations.
Who is this for?
Women and men with advanced (some stage III) or metastatic (stage IV) breast cancer that will potentially respond to the chemotherapy drug docetaxel (Taxotere®).    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD8186, by mouth, daily, ongoing</li> <li class="seamTextUnorderedListItem">Docetaxel (Taxotere®), by IV, monthly, ongoing</li> <li class="seamTextUnorderedListItem">2 biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AZD8186 is an experimental targeted therapy that works by inhibiting PI3K proteins and is designed for cancers that are characterized as being deficient in PTEN.</li> <li class="seamTextUnorderedListItem">Taxotere is a chemotherapy commonly used to treat breast cancer. </li> <li class="seamTextUnorderedListItem">This study is also enrolling patients with other types of cancers.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03218826' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/risk/factors/genetics' target='_blank'>Breastcancer.org: Genetics</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pi3kbeta-inhibitor-azd8186' target='_blank'>NCI Dictionary: AZD8186</a> </li></ul>
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