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(Last updated: May 21, 2020)

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1

NEAREST SITE: 2260 miles
Allegheny Health Network (AHN) - Allegheny General Hospital ONLY
Pittsburgh,PA

VISITS: 1 visit a week for 3 weeks, then monthly visits thereafter

PHASE: II

NCT ID: NCT02738866

Palbociclib With Fulvestrant for ER+, HER2- Advanced Breast Cancer

Phase II Trial of Palbociclib With Fulvestrant in Individuals With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer Who Have Progressed on Treatment With Palbociclib and an Aromatase Inhibitor Scientific Title

Purpose
To study the safety and effects (good and bad) of using Ibrance and Faslodex to treat people with advanced breast cancer who have previously been treated with Ibrance and an aromatase inhibitor.
Who is this for?
People with ER positive, HER2 negative advanced (some stage III) or metastatic (stage IV) breast cancer and have already been treated with palbociclib (Ibrance®) and an aromatase inhibitor.    Full eligibility criteria
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  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), by mouth, once daily (3 weeks on, 1 week off)</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, once a week for 3 weeks then once a month thereafter</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®) is a CDK4/6 inhibitor approved to treat hormone receptor positive (ER+ and/or PR+), HER2 negative breast cancer in combination with an anti-estrogen therapy. </li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is an anti-estrogen therapy approved to treat postmenopausal women with metastatic breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02738866' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://pubchem.ncbi.nlm.nih.gov/compound/Fulvestrant#section=Top' target='_blank'>PubChem: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.astrazeneca.com/media-centre/press-releases/2017/faslodex-receives-us-fda-approval-as-monotherapy-for-expanded-use-in-breast-cancer.html' target='_blank'>AstraZeneca Press Release: Fulvestrant</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancercare.org.uk/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/targeted-therapy/palbociclib-ibrance#what%20is%20palbociclib' target='_blank'>BreastCancerCare UK: Palbociclib</a> </li></ul>
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