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(Last updated: May 21, 2020)

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1

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Number of visits unavailable

PHASE: II

NCT ID: NCT02286687

Talazoparib for Advanced Breast (and Other) Cancer with BRCA1/2 or Other Genetic Changes

Phase II Study of the PARP Inhibitor BMN 673 (Talazoparib Tosylate) in Advanced Cancer Patients With Somatic Alterations in BRCA1/2, Mutations/Deletions in PTEN or PTEN Loss, a Homologous Recombination Defect, Mutations/Deletions in Other BRCA Pathway Genes and Germline Mutation in BRCA1/2 (Not Breast or Ovarian Cancer) Scientific Title

Purpose
To determine whether the drug talazoparib (Talzenna®) helps treat people with advanced breast cancer who have certain genetic mutations or deletions, including BRCA1/2 mutations. The safety of this drug will also be studied.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer and certain genetic alterations or mutations, including the BRCA1/2 mutations.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib (Talzenna®), by mouth, daily, ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Talazoparib® is a type of drug called a PARP inhibitor. It works by preventing the PARP protein from repairing damaged DNA in tumor cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02286687' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/conference-coverage/sabcs-2017/talazoparib-improves-pfs-in-brcapositive-breast-cancer' target='_blank'>OncLive: Talazoparib</a> </li></ul>
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