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(Last updated: November 13, 2019)

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1

NEAREST SITE: 1643 miles
M D Anderson Cancer Center
Houston,TX

VISITS: Weekly visits, ongoing

PHASE: I

NCT ID: NCT01552434

Bevacizumab & Temsirolimus with Valproic Acid or Cetuximab in Advanced Breast Cancer

A Phase I Trial of Bevacizumab, Temsirolimus Alone and in Combination With Valproic Acid, or Cetuximab in Patients With Advanced Malignancy and Other Indications Scientific Title

Purpose
To compare the effects (good and bad) of bevacizumab (Avastin®) and temsirolimus (Torisel®) alone or with valproic acid (Depakote®) or cetuximab (Erbitux®).
Who is this for?
Women and men with advanced (some stage III) or metastatic (stage IV) breast cancer and have previously been treated with a standard therapy.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Temsirolimus, by IV, once a week </li> <li class="seamTextUnorderedListItem">Bevacizumab, by IV, twice a month </li> <li class="seamTextUnorderedListItem">Cetuximab, by IV, once a week </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Temsirolimus, by IV, once a week </li> <li class="seamTextUnorderedListItem">Bevacizumab, by IV, twice a month </li> <li class="seamTextUnorderedListItem">Valproic acid, by mouth, daily on the first and third week of every month. </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: </i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Temsirolimus, by IV, once a week </li> <li class="seamTextUnorderedListItem">Bevacizumab, by IV, twice a month</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Avastin is a targeted therapy that blocks the growth of the blood vessels that cancer cells need to survive. It is used to treat metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Torisel is a type of targeted therapy called an mTOR inhibitor. It is approved to treat kidney cancer. </li> <li class="seamTextUnorderedListItem">Depakote is an anti-seizure medication that researchers think may also slow cancer cell growth. </li> <li class="seamTextUnorderedListItem">Erbitux is a type of targeted therapy called an EGFR inhibitor. It is approved to treat head, neck and colorectal cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01552434' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.gene.com/patients/medicines/avastin' target='_blank'>Genetech: Avastin</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.oncolink.org/cancer-treatment/oncolink-rx/temsirolimus-torisel-r' target='_blank'>Oncolink: Temsirolimus</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/cetuximab' target='_blank'>Cancer Research UK: Cetuximab</a> </li></ul>
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