Browse Trials
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(Last updated: May 21, 2020)
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1
A Study of the Inherited KRAS-Variant Mutation and Breast Cancer Risk
Clinical Validation of the Role of microRNA Binding Site Mutations in Cancer Risk, Prevention and Treatment Scientific Title
Purpose
To analyze the association between the KRAS-variant mutation and cancer risk.
Who is this for?
People with stage I, stage II, stage III or metastatic (stage IV) breast cancer
Full eligibility criteria
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<p class="seamTextPara"> All participants will provide a saliva sample and answer questionnaires periodically over 10 years. Participants will be able to get their KRAS-variant test results after submitting their sample, at a discounted cost ($295). </p> <p class="seamTextPara"> Click here for the <a href="http://mirakind.org/study-eligibility-questionnaire/">Eligibility Survey</a></p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An inherited genetic mutation, a KRAS-variant, may increase a person's risk of developing breast or other types of cancer. </li> <li class="seamTextUnorderedListItem">This study will follow participants for 10 years. </li> <li class="seamTextUnorderedListItem">The researchers will also look at the effect that different lifestyle factors have on cancer risk. </li> <li class="seamTextUnorderedListItem">All participants will have a saliva sample tested for the KRAS-variant. </li> <li class="seamTextUnorderedListItem">To be eligible, participants must have a personal or family history of breast cancer.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02253251' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://mirakind.org/wp-content/uploads/2014/03/Understanding_Results.pdf' target='_blank'>MiraKind.org: KRAS-Variant</a> </li><li class='seamTextUnorderedListItem'><a href='https://miradx.com/test/kras-variant/' target='_blank'>MiraDx: KRAS-Variant Testing</a> </li><li class='seamTextUnorderedListItem'><a href='http://mirakind.org/study-eligibility-questionnaire/' target='_blank'>MiraKind Eligibility Survey</a> </li></ul>
2
BRCA Gene Mutations in Latinas with Breast Cancer
BRCA1 and BRCA2 Mutations and Triple Negative Disease in Hispanic/Latino Breast Cancer Subjects Scientific Title
Purpose
To study DNA samples taken from saliva and the medical histories of Latinas who have been diagnosed with breast cancer.
Who is this for?
Women with stage I, stage II, stage III or metastatic (stage IV) breast cancer and who are Hispanic/Latino
Full eligibility criteria
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<p class="seamTextPara"> All participants will: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Provide a saliva sample </li> <li class="seamTextUnorderedListItem">Complete a questionnaire </li> <li class="seamTextUnorderedListItem">Provide a copy of pathology report</li> </ul> <p class="seamTextPara"> No study visits are required. The consent process can be done by phone (in English or Spanish) and the questionnaire and saliva collections completed by U.S. mail.</p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Some women who have triple negative (ER-, PR-,HER2-) breast cancer also have a BRCA1 or BRCA2 genetic mutation.</li> <li class="seamTextUnorderedListItem">The number of Latinas with triple negative breast cancer who also have a BRCA1/2 mutation is not known. </li> <li class="seamTextUnorderedListItem">Learning more about BRCA1/2 mutation rates among Latnas will help researchers provide better treatment to this group of women.</li> </ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT01251900' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA' target='_blank'>NCI Fact Sheet: BRCA1 & BRCA2</a> </li><li class='seamTextUnorderedListItem'><a href='http://ww5.komen.org/BreastCancer/InheritedGeneticMutations.html' target='_blank'>Susan G. Komen: Gene Mutations</a> </li><li class='seamTextUnorderedListItem'><a href='http://ww5.komen.org/TripleNegativeBreastCancer.html' target='_blank'>Susan G. Komen: Triple Negative Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.gov/espanol/tipos/seno' target='_blank'>Cancer.gov: Cáncer de seno</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancer.org/espanol/cancer/cancerdeseno/' target='_blank'>American Cancer Society: Cáncer de seno</a> </li></ul>
3
Telephone Support to Reduce Fatigue in Women With Metastatic Breast Cancer
Telephone Support for Metastatic Breast Cancer Patients Scientific Title
Purpose
To evaluate whether a telephone-based psychotherapy program can reduce fatigue and improve activity level, mood, and cognition.
Who is this for?
Women with metastatic (stage IV) breast cancer being treated at the Indiana University (IU) Simon Cancer Center, Eskenazi Health, IU Health North, IU Health Bloomington, IU Health Ball Memorial, Franciscan Health, or St. Vincent Health.
Full eligibility criteria
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<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acceptance and Commitment Therapy: 50-minute phone sessions, weekly, for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Education/Support: 50-minute phone sessions, weekly, for 6 weeks</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Follow-up</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">30-minute phone assessments at 2 weeks, 3 months, and 6 months after study activities</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The type of psychotherapy being studied is called Acceptance and Commitment Therapy (ACT). </li> <li class="seamTextUnorderedListItem">It teaches mindfulness exercises as well as ways to identify and engage in activities consistent with your personal values.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03998618' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pubmed/29327085' target='_blank'>Pubmed Abstract: Acceptance and commitment therapy for symptom interference in metastatic breast cancer patients</a> </li></ul>
4
Online Program with an Occupational Therapist to Help Women Treated for DCIS, Stage I, Stage II, or Stage III Breast Cancer Manage Fatigue
Feasibility and Effectiveness of an Internet-based Intervention to Manage Fatigue in Breast Cancer Survivors Scientific Title
Purpose
To evaluate whether six weeks of online meetings with an occupational therapist who teaches fatigue management skills helps reduce fatigue or the effects of fatigue on quality of life.
Who is this for?
Women who were treated for DCIS, stage I, stage II, or stage III breast cancer who are currently not receiving chemotherapy or radiation, are experiencing fatigue, and are not taking medications for depression, sleep issues, or fatigue.
Full eligibility criteria
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<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Online sessions with an occupational therapist, 45 minutes each, weekly, for 6 weeks</li> <li class="seamTextUnorderedListItem">A workbook containing information, strategies, and skills to help you manage your fatigue</li> <li class="seamTextUnorderedListItem">Help from the occupational therapist in applying these skills to your life</li></ul>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Fatigue is a common side effect of breast cancer treatment.</li> <li class="seamTextUnorderedListItem">This study will evaluate whether six weeks of online meetings with an occupational therapist who teaches fatigue management skills helps reduce fatigue or the effects of fatigue on quality of life.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04160182' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/side_effects/fatigue' target='_blank'>Breastcancer.org: Fatigue</a> </li></ul>
5
CSC Online Survey: The Cancer Experience Registry
Cancer Experience Registry: An Online Initiative to Understand the Experiences of Those Impacted by a Cancer Diagnosis (CER) Scientific Title
Purpose
To learn more about the emotional and social experiences and needs of people affected by cancer.
Who is this for?
People diagnosed with DCIS, stage I, stage II, stage III, or metastatic (stage IV) breast cancer and people who provide care to individuals diagnosed with cancer.
Full eligibility criteria
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<p class="seamTextPara"> Participation in this study involves the completion of an online questionnaire. The questionnaire may be accessed at the following link: </p> <a href="http://www.cancersupportcommunity.org/MainMenu/ResearchTraining/Cancer-Experience-Registry.html" target="_blank">www.cancerexperienceregistry.org</a>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The researchers hope to use this information to improve the educational materials and the overall quality of care that cancer patients receive. </li> <li class="seamTextUnorderedListItem">This study is also enrolling people diagnosed with other types of cancer. </li> <li class="seamTextUnorderedListItem">The data collected from this study can be found <a href="https://www.cancersupportcommunity.org/RegistryIndexReport2017" target="_blank">here.</a></li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02333604' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerexperienceregistry.org/' target='_blank'>Cancer Support Community Study Website: Cancer Experience Registry</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancersupportcommunity.org/RegistryIndexReport2017' target='_blank'>Cancer Support Community: Cancer Experience Registry Index Report 2017</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youtube.com/watch?v=SyyUYqyNaCc' target='_blank'>Cancer Support Community YouTube Channel: What is the Cancer Experience Registry?</a> </li></ul>
6
MBC Connect Patient Registry: Sharing MBC History, Experiences, and Quality of Life
MBC Connect -- Patient Powered. Research Driven Scientific Title
Purpose
To collect information about the experiences of people with metastatic breast cancer for researchers and clinicians and to provide personalized information to each participant.
Who is this for?
People with metastatic (stage IV) breast cancer.
Full eligibility criteria
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- What's involved?
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">You will be asked to fill out surveys about your breast cancer diagnosis, treatment history and quality of life.</li> <li class="seamTextUnorderedListItem">Based on information you enter, you will get personalized insights and alerts with MBC news, events, and clinical trial opportunities.</li> </ul> <p class="seamTextPara"> To join the registry, click here: <a href="https://www.mbcconnect.org/" target="_blank">www.mbcconnect.org/</a><p></p></p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">MBC Connect is a free, web and mobile-friendly registry that collects information about the experiences of people with metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">Joining the registry allows you to receive personalized information about MBC-related news, events, and clinical trial opportunities. </li> <li class="seamTextUnorderedListItem">Researchers and clinicians will be able to analyze information collected in the registry in research studies. </li> <li class="seamTextUnorderedListItem">MBC Connect is available in English and Spanish.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'><a href='https://www.mbcconnect.org/' target='_blank'>MBC Connect</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mbcalliance.org/' target='_blank'>Metastatic Breast Cancer Alliance</a> </li></ul>
7
No Travel Required
VISITS: Online forms, questionnaires, saliva sample by mail
PHASE: NA
NCT ID: NCT00000002
MBC Project: Collecting Information About Metastatic Breast Cancer To Further Research
The Metastatic Breast Cancer Project Scientific Title
Purpose
To accelerate research in treating, curing and preventing metastatic breast cancer.
Who is this for?
People with metastatic (stage IV) breast cancer.
Full eligibility criteria
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- What's involved?
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<p class="seamTextPara"> Your participation will include the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Complete a simple online form about yourself and your cancer</li> <li class="seamTextUnorderedListItem">Fill out an online consent form that gives your permission for the researchers to obtain copies of your medical records and some of your stored tumor tissue</li> <li class="seamTextUnorderedListItem">Provide a saliva sample and send back via U.S. mail </li> </ul> <p class="seamTextPara"> To learn more and/or to participate, click here: <a href="https://www.mbcproject.org/" target="_blank">https://www.mbcproject.org/</a><p></p></p>
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<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The goal of the Metastatic Breast Cancer Project is to accelerate research in treating, curing and preventing metastatic breast cancer. </li> <li class="seamTextUnorderedListItem">If you take part in the project, you will fill out questionnaires, provide a saliva sample, and share a piece of your stored tumor tissue and copies of your medical records with the researchers. </li> <li class="seamTextUnorderedListItem">The researchers believe analyzing this data will help them learn more about metastatic breast cancer and make more research advances. </li> <li class="seamTextUnorderedListItem">The MBC Project was created by a coalition of researchers and breast cancer advocacy organizations.</li></ul>
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<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'><a href='https://www.mbcproject.org/' target='_blank'>The Metastatic Breast Cancer Project</a> </li></ul>
