Browse Trials

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The targeted therapy each patient receives will be selected based on their tumor's specific genetic profile.</li> <li class="seamTextUnorderedListItem">Your treatment may include one or more of the following: Abemaciclib, Afatinib, Crizotinib, Nivolumab, Ipilimumab, Olaparib, Palbociclib, Pembrolizumab, Regorafenib, Sunitinib, Talazoparib, Temsirolimus, Trastuzumab, Pertuzumab, Vemurafenib, Cobimetinib</li> <li class="seamTextUnorderedListItem">Targets or mutations: ALK, ATM, BRAF, BRAF V600E/D/K/R, BRCA1/2, CDK4, CDK6, CDKN2A, CSF1R, ERBB2, high mutational load and others, KIT, MET, MSI-H, mTOR, NRG1, PALB2, PDGFR, POLD1, POLE, RAF-1, RET, ROS1, TSC, VEGFR.</li></ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02693535' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.tapur.org/' target='_blank'>ASCO: Study website</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/conference-coverage/asco-2016/dr-edward-kim-on-ascos-tapur-trial' target='_blank'>OncLive: About TAPUR (video)</a> </li></ul>

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Molecular profiling is a process that identifies mutations and biomarkers in your tumor's DNA that have FDA-approved matched therapies or are eligible for clinical studies.</li> <li class="seamTextUnorderedListItem">In this study, a sample of your tumor will be analyzed (called molecular profiling) at Cedars-Sinai Medical Center in California.</li> <li class="seamTextUnorderedListItem">Targets or mutations: varies based on your test results</li></ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03098576' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.cancercenter.com/treatments/tumor-molecular-profiling/' target='_blank'>Cancer Treatment Center of America: Tumor Molecular Profiling</a> </li></ul>

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This study is investigating whether genetic information obtained from your tumor and blood can help doctors personalize cancer treatments.</li></ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03281902' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mayo.edu/pmts/mc7000-mc7099/mc7024-103.pdf' target='_blank'>Mayo Clinic: PROMISE Trial Sept. 2019 Newsletter</a> </li><li class='seamTextUnorderedListItem'><a href='http://mayoresearch.mayo.edu/center-for-individualized-medicine/breast-cancer-study.asp' target='_blank'>Mayo Clinic: Study website</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.youtube.com/watch?v=onKf2JLXQxE&feature=youtu.be' target='_blank'>PROMISE Breast Cancer Clinical Trial (video)</a> </li></ul>

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Molecular profiling of a tumor may identify genetic mutations or biomarkers that suggest the tumor is likely to respond to a currently available targeted therapy. </li> <li class="seamTextUnorderedListItem">It is not known if choosing metastatic breast (or other types of) cancer treatment based on the tumor's molecular profile is more effective than the current standard of care. </li> <li class="seamTextUnorderedListItem">All patients who enroll in this study will have molecular profiling performed on a biopsy of their tumor. </li> <li class="seamTextUnorderedListItem">If there is no mutation or biomarker found, the patient will receive the treatment their doctor determines is the best option. </li> <li class="seamTextUnorderedListItem">If a mutation or biomarker is found and there is an FDA-approved drug for the tumor type, patients will be offered that treatment. </li> <li class="seamTextUnorderedListItem">If there is a mutation or biomarker found but no FDA-approved drug that targets it, patients will be randomly assigned to either a targeted therapy or the standard of care.</li> <li class="seamTextUnorderedListItem">Targets or mutations: vary based on test results.</li></ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02152254' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02152254?term=NCT02152254&rank=1' target='_blank'>ClinicalTrials.gov: Trial Information</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.breastcancer.org/research-news/20130816' target='_blank'>BreastCancer.org: Molecular Profiling Pilot Study</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mdanderson.org/publications/oncolog/january-2015/impact2-study-tests-benefits-of-personalized-cancer-treatment-ba.html' target='_blank'>MD Anderson: article</a> </li></ul>

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">If you take part in this study, you will complete a questionnaire about the decision support tool.</li> </ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02918474' target='_blank'>ClinicalTrials.gov</a> </li></ul>

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Health care coaches are trained to talk to and educate cancer patients and their family members about care goals and shared decision making.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of metastatic cancer.</li></ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03154190' target='_blank'>ClinicalTrials.gov</a> </li></ul>

<p class="seamTextPara"> The information obtained from the liquid biopsy may help guide recommendations for your next treatment.</p>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02965755' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://ww5.komen.org/KomenPerspectives/Tumor-profiling-%E2%80%93-personalizing-treatment-for-breast-cancer.html' target='_blank'>Komen: Tumor Profiling-Personalizing Treatment for Breast Cancer</a> </li></ul>

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">RealRisks is a web-based decision aid for patients that is designed to work with the Breast Cancer Risk Navigation tool developed for doctors.</li> </ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03069742' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://realrisks.dbmi.columbia.edu/' target='_blank'>RealRisks Website</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.facingourrisk.org/understanding-brca-and-hboc/information/risk-management/chemoprevention-breast-cancer/basics/overview.php' target='_blank'>Chemoprevention</a> </li></ul>

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">There are two phases to this study. </li> <li class="seamTextUnorderedListItem">In phase I, the researchers will collect feedback about the Decision Aid from breast cancer patients age 70 and over who were treated at least six months ago and their family members and clinicians. </li> <li class="seamTextUnorderedListItem">The researchers will use this feedback to improve the Decision Aid. </li> <li class="seamTextUnorderedListItem">In Phase II, the researchers will see if the revised Decision Aid helps women age 70 and older who have been diagnosed with breast cancer make treatment decisions.</li> </ul>

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02823262' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicaltrials.gov/ct2/show/NCT02823262?term=NCT02823262&rank=1' target='_blank'>The Decision Aid</a> </li></ul>