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Lymphedema

Immunotherapy for the Treatment of Breast Cancer-Related Lymphedema

Immunotherapy for the Treatment of Breast Cancer Related Upper Extremity Lymphedema (BCRL) (NCT02494206)

Summary

Lymphedema–a painful swelling of the arm and hand—is a common side effect of breast cancer treatment. QBX258 (combination of VAK296 and QAX56) is a new type of immunotherapy that may help reduce lymphedema symptoms by engaging the body's natural inflammatory response. This study is investigating the efficacy of QBX258 in women with stage I-II breast cancer who develop lymphedema following breast cancer treatment. To be eligible, a woman must have a body-mass index (BMI) between 18 and 30.

  • Participation TimeVisits every 4 weeks
  • Participating research sites
    Research sites:
    Call BCT: (415) 476-3793
What's Involved    Contact information: Call BCT at (415) 476-3793

Evaluating a Web-Based Program to Reduce and Treat Lymphedema in Breast Cancer Survivors

The-Optimal-Lymph-Flow ™: An e-Health Approach to Enhancing Management of Chronic Pain and Symptoms Related to Lymphedema Among Women Treated for Breast Cancer (NCT02462226)

Summary

The-Optimal-Lymph-Flow™ system is a web-based self-care program designed to help women treated for breast cancer decrease and manage pain and symptoms related to lymphedema. The system advises women on safe, feasible, and easily-integrated-into-daily routine exercises to promote lymph flow and drainage. This study is comparing the safety and effectiveness of the web-based The-Optimal-Lymph-Flow™ system to a standard web-based program for lymphedema. To be eligible, patients must report persistent or intermittent pain, including aching, tenderness, soreness. Patients do not have to have lymphedema to take part in this study.

  • Participation Time2 visits over 3 months
  • Participating research sites
    Research sites:
    Call BCT: (415) 476-3793
What's Involved    Contact information: Call BCT at (415) 476-3793

Integrative Therapy Program to Prevent Lymphedema after Surgery

Prevention of Secondary Lymphedema by Utilizing Self-management Education in Conjunction With Acupuncture Among Breast Cancer Patients Who Are at High Risk of Developing Lymphedema (NCT02528539)

Summary

Lymphedema is a painful swelling in the arm, hand, or wrist caused by a build-up of lymph fluid. Women whose breast cancer surgery includes removing lymph nodes under the arm that contain cancer cells--called an axillary lymph node dissection--are at increased risk of developing lymphedema. Researchers have developed an integrative therapy program for lymphedema that includes acupuncture along with education on the benefits of a healthy diet, exercise, and lymphatic drainage techniques women can do on their own. This study is evaluating the feasibility and effectiveness of using this integrative therapy program to reduce the risk of lymphedema after breast cancer surgery. To be eligible, women must be newly diagnosed with stage I-III breast cancer and have had an axillary lymph node dissection within 4-6 weeks prior to enrollment.

  • Participation TimeVisits weekly for 10 weeks, then every 3 months for 1 year
  • Participating research sites
    Research sites:
    Call BCT: (415) 476-3793
What's Involved    Contact information: Call BCT at (415) 476-3793

National Breast Cancer and Lymphedema Registry

National Breast Cancer and Lymphedema Registry (NCT01580800)

Summary

Lymphedema, a painful swelling of the hand, wrist, and/or arm, is a potential long-term side effect of breast cancer treatments that can have a large impact on patients' quality of life. The National Breast Cancer Lymphedema Registry is designed to collect information about the effect early diagnostic and treatment strategies have on the development of lymphedema, its severity, and its impact on quality of life.

  • Participation TimeOnline questionnaires and email contact
  • No Visits Required for this TrialNo travel required 
What's Involved    Contact information

Using MRI to Monitor How Lymphedema Responds to Manual Lymphatic Drainage Therapy

Imaging Noninvasively With Functional-MRI for Onset, Response and Management of Lymphatic Impairment (NCT02611557)

Summary

Lymphedema--a painful swelling of the hand, wrist and/or arm--is a potential long-term side effect of breast cancer treatment. Manual lymphatic drainage (MLD) therapy uses light touch to move excess lymph and fluid out of the tissue and back into the lymphatic vessels. This study will use magnetic resonance imaging (MRI) to monitor how lymphedema responds to personalized MLD therapy in women who were diagnosed with DCIS or stage I-II breast cancer and are experiencing breast cancer treatment-related lymphedema.

  • Participation TimeNumber of visits unavailable
  • Participating research sites
    Research sites:
    Call BCT: (415) 476-3793
What's Involved    Contact information: Call BCT at (415) 476-3793

Impact of Lymphedema on Quality of Life After Breast Cancer

Prospective Analysis of Symptoms, Functionality and Quality of Life Questionnaires to Evaluate Lymphedema in Patients Following Treatment for Breast Cancer. (NCT01521741)

Summary

Breast cancer treatments can result in long-term, painful swelling of the arm and hand, a condition called lymphedema. The goal of this study is to determine how the symptoms and functional disability that accompany lymphedema can impact breast cancer survivors' quality of life. To be eligible, participants must be planning to have surgery and receive follow-up care for breast cancer at Massachusetts General Hospital.

What's Involved    Contact information

Detecting and Monitoring Lymphedema

Evaluation of the Validity of BIS as a Tool for Quantification of Lymphedema Through Comparison With Perometry and Self-Report (NCT01544335)

Summary

Lymphedema is a painful swelling of the arm that can develop as a result of breast cancer treatment. Early detection and treatment of lymphedema may be able to help reduce or control this swelling. To improve early detection, better methods of measuring lymph fluid in the arm are needed. Bioimpedance spectroscopy involves using an extremely small electrical current to measure the amount of lymph fluid present in the arm. The goal of this study is to determine whether bioimpedance spectroscopy is as effective at detecting and monitoring lymphedema as a measurement device called a perometer. To be eligible, participants must be receiving follow-up care at Massachusetts General Hospital or the Dana-Farber/Harvard Cancer Center.

What's Involved    Contact information

Acupuncture for Chronic Lymphedema

Acupuncture for Chronic Lymphedema: A Randomized Wait-list Controlled Trial (NCT01706081)

Summary

Breast cancer treatment can result in lymphedema, a painful swelling of the arm or hand. It can develop right after breast cancer treatment or weeks, months or even years later. A small, preliminary study conducted by these researchers found that more than one-third of the 33 patients studied had at least a 30 percent reduction in lymphedema following acupuncture treatment, with no serious side effects occurring during the study or in the six months after treatment ended. This study, which is enrolling a larger group of patients, will allow the researchers to continue to study if acupuncture can reduce lymphedema and how long the effects last after acupuncture treatments ends. To be eligible, participants must have lymphedema for at least 6 months and no more than 5 years.
This is a Phase II trial

What's Involved    Contact information

Axillary Reverse Mapping During Surgery to Reduce Risk of Lymphedema

ARM: Axillary Reverse Mapping (NCT00572481)

Summary

Breast cancer surgery typically involves removing on or more of the axially lymph nodes--the lymph nodes under the arm, where the cancer may have spread. The procedure can increase a woman's risk of developing lymphedema, a painful swelling of the hand, wrist or arm. The location of the lymphatic drainage system may be a risk factor for lymphedema. This study is using axillary reverse mapping (ARM), a procedure that involves injecting blue dye into the lymph system, to identify where the lymph nodes drain and to reduce the risk of lymphedema after breast cancer surgery.
This is a Phase II trial

What's Involved    Contact information