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Lymphedema

Evaluating a Web-Based Program to Reduce and Treat Lymphedema in Breast Cancer Survivors

The-Optimal-Lymph-Flow ™: An e-Health Approach to Enhancing Management of Chronic Pain and Symptoms Related to Lymphedema Among Women Treated for Breast Cancer (NCT02462226)

Summary

The-Optimal-Lymph-Flow™ system is a web-based self-care program designed to help women treated for breast cancer decrease and manage pain and symptoms related to lymphedema. The system advises women on safe, feasible, and easily-integrated-into-daily routine exercises to promote lymph flow and drainage. This study is comparing the safety and effectiveness of the web-based The-Optimal-Lymph-Flow™ system to a standard web-based program for lymphedema. To be eligible, patients must report persistent or intermittent pain, including aching, tenderness, soreness. Patients do not have to have lymphedema to take part in this study.

Integrative Therapy Program to Prevent Lymphedema after Surgery

Prevention of Secondary Lymphedema by Utilizing Self-management Education in Conjunction With Acupuncture Among Breast Cancer Patients Who Are at High Risk of Developing Lymphedema (NCT02528539)

Summary

Lymphedema is a painful swelling in the arm, hand, or wrist caused by a build-up of lymph fluid. Women whose breast cancer surgery includes removing lymph nodes under the arm that contain cancer cells--called an axillary lymph node dissection--are at increased risk of developing lymphedema. Researchers have developed an integrative therapy program for lymphedema that includes acupuncture along with education on the benefits of a healthy diet, exercise, and lymphatic drainage techniques women can do on their own. This study is evaluating the feasibility and effectiveness of using this integrative therapy program to reduce the risk of lymphedema after breast cancer surgery. To be eligible, women must be newly diagnosed with stage I-III breast cancer and have had an axillary lymph node dissection within 4-6 weeks prior to enrollment.

National Breast Cancer and Lymphedema Registry

National Breast Cancer and Lymphedema Registry (NCT01580800)

Summary

Lymphedema, a painful swelling of the hand, wrist, and/or arm, is a potential long-term side effect of breast cancer treatments that can have a large impact on patients' quality of life. The National Breast Cancer Lymphedema Registry is designed to collect information about the effect early diagnostic and treatment strategies have on the development of lymphedema, its severity, and its impact on quality of life.

  • Participation TimeOnline questionnaires and email contact
  • No Visits Required for this TrialNo travel required 

Using MRI to Monitor How Lymphedema Responds to Manual Lymphatic Drainage Therapy

Imaging Noninvasively With Functional-MRI for Onset, Response and Management of Lymphatic Impairment (NCT02611557)

Summary

Lymphedema--a painful swelling of the hand, wrist and/or arm--is a potential long-term side effect of breast cancer treatment. Manual lymphatic drainage (MLD) therapy uses light touch to move excess lymph and fluid out of the tissue and back into the lymphatic vessels. This study will use magnetic resonance imaging (MRI) to monitor how lymphedema responds to personalized MLD therapy in women who were diagnosed with DCIS or stage I-II breast cancer and are experiencing breast cancer treatment-related lymphedema.

Impact of Lymphedema on Quality of Life After Breast Cancer

Prospective Analysis of Symptoms, Functionality and Quality of Life Questionnaires to Evaluate Lymphedema in Patients Following Treatment for Breast Cancer. (NCT01521741)

Summary

Breast cancer treatments can result in long-term, painful swelling of the arm and hand, a condition called lymphedema. The goal of this study is to determine how the symptoms and functional disability that accompany lymphedema can impact breast cancer survivors' quality of life. To be eligible, participants must be planning to have surgery and receive follow-up care for breast cancer at Massachusetts General Hospital.

Detecting and Monitoring Lymphedema

Evaluation of the Validity of BIS as a Tool for Quantification of Lymphedema Through Comparison With Perometry and Self-Report (NCT01544335)

Summary

Lymphedema is a painful swelling of the arm that can develop as a result of breast cancer treatment. Early detection and treatment of lymphedema may be able to help reduce or control this swelling. To improve early detection, better methods of measuring lymph fluid in the arm are needed. Bioimpedance spectroscopy involves using an extremely small electrical current to measure the amount of lymph fluid present in the arm. The goal of this study is to determine whether bioimpedance spectroscopy is as effective at detecting and monitoring lymphedema as a measurement device called a perometer. To be eligible, participants must be receiving follow-up care at Massachusetts General Hospital or the Dana-Farber/Harvard Cancer Center.