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Inflammatory Breast Cancer
Biomarker status:
 Hormone-positive (ER+ and/or PR+)
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Inflammatory Breast Cancer
Biomarker status:
 Hormone-positive (ER+ and/or PR+)
 HER2-positive (HER2+)
 Triple negative (ER-/PR-/HER2-)

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Triple Negative Breast Cancer
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Fertility Preservation

Improving Fertility Preservation

A Randomized Open Label Clinical Trial of Fixed Dose Letrozole vs. Titrated Letrozole for In Vitro Fertilization With Cryopreservation of Oocytes and Embryos in Breast Cancer Patients (NCT01035099)

Summary

Some breast cancer treatments may affect a woman's ability to become pregnant. Women can choose to undergo in vitro fertilization (IVF) prior to chemotherapy or radiation so that they can store their eggs and try to become pregnant at a later date. IVF involves ovarian stimulation and egg retrieval. Conventional ovarian stimulation often results in very high estrogen levels, which may be unsafe for breast cancer patients. Letrozole (Femara®) is an aromatase inhibitor used to treat hormone-sensitive tumors in postmenopausal women. It can reduce estrogen levels during IVF while still allowing for effective ovarian stimulation. This trial will compare the effectiveness of two different ways of administering letrozole during ovarian stimulation in patients who are scheduled to undergo IVF for fertility preservation due to breast cancer.

A Study of the Effect Tamoxifen Has on the Ovaries

Investigating the Impact of Tamoxifen Therapy on Ovarian Aging (NCT01384526)

Summary

Research has been conducted on the effect that chemotherapy can have on the ovaries of premenopausal women being treated for early-stage breast cancer. But little is known about the long-term effects that anti-estrogen therapies might have on ovarian function. This information would help breast cancer patients of reproductive age make more informed and empowered decisions regarding their treatment. The purpose of this study is to explore the effect that tamoxifen has on the ovaries of premenopausal women. To be eligible, participants must be diagnosed with stage I-III breast cancer or ductal carcinoma in situ, or determined to be high risk for breast cancer.