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1

Elly Mobile Application to Reduce <span class="highlight">Anxiety</span> in People Living With Breast Cancer

IIT2020-13-GRESHAM-ELLY: Evaluating the Effect of a Mobile Audio Companion (Elly) to Reduce <span class="highlight">Anxiety</span> in Cancer Patients

Purpose: To study if the Elly iPhone application reduces <span class="highlight">anxiety,</span> stress, loneliness, and social isolation.

Who is this for?: People with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who are receiving treatment or have received treatment within the past 6 months. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Elly iPhone application</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">The Elly mobile application delivers daily audio recordings aimed at reducing <span class="highlight">anxiety,</span> stress, loneliness, and social isolation.</li> <li class="seamTextUnorderedListItem">In this trial, the Elly mobile application is only available on iPhones.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04604158' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ellyhealth.com/' target='_blank'>Elly Health: Elly Mobile App</a> </li></ul>
1

Elly Mobile Application to Reduce <span class="highlight">Anxiety</span> in People Living With Breast Cancer

IIT2020-13-GRESHAM-ELLY: Evaluating the Effect of a Mobile Audio Companion (Elly) to Reduce <span class="highlight">Anxiety</span> in Cancer Patients
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Nearest Location:
342 miles
Cedars Sinai Medical Center
Los Angeles, CA

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Visits:
Number of visits unavailable

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ClinicalTrials.gov: NCT04604158

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Phase NA

2

CBD for Aromatase Inhibitor Joint and Muscle Pain

Phase 2 Trial of Cannabidiol (CBD) for Treatment of Aromatase Inhibitor-Associated Arthralgias

Purpose: To study the safety and effects (good and bad) of cannabidiol (CBD, Epidiolex®) for joint and muscle pain during aromatase inhibitor treatment.

Who is this for?: Women with stage I, stage II, or stage III breast cancer who received surgery at least 3 months ago and are receiving anastrozole (Arimidex®), letrozole (Femara®), or exemestane (Aromasin®). You must be experiencing joint and/or muscle pain. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cannabidiol (CBD, Epidiolex®), by mouth, daily for 4 months</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cannabidiol (CBD) is a component of the cannabis sativa (marijuana) and hemp plants.</li> <li class="seamTextUnorderedListItem">Studies of CBD have led to its approval by the FDA for certain childhood seizure disorders. Researchers have also been studying the use of CBD to manage <span class="highlight">anxiety</span> and pain.</li> <li class="seamTextUnorderedListItem">Cannabidiol (Epidiolex®) is an FDA-approved seizure drug.</li> <li class="seamTextUnorderedListItem">Premenopausal and perimenopausal women will also be given the drug goserelin (Zoladex®) that will put you in temporary menopause.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04754399' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/complementary-therapy/types/medical-cannabis' target='_blank'>Breastcancer.org: Medical Cannabis and CBD</a> </li></ul>
2

CBD for Aromatase Inhibitor Joint and Muscle Pain

Phase 2 Trial of Cannabidiol (CBD) for Treatment of Aromatase Inhibitor-Associated Arthralgias
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Nearest Location:
2054 miles
University of Michigan Rogel Cancer Center
Ann Arbor, MI

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Visits:
Number of visits unavailable

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ClinicalTrials.gov: NCT04754399

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Phase II

3

Registry of People With Brain Metastasis

Evaluation of the Natural History of and Specimen Banking for Patients With Tumors of the Central Nervous System

Purpose: To study brain tumors and discover areas for further brain tumor research.

Who is this for?: People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis). View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Physical and neurological exams</li> <li class="seamTextUnorderedListItem">Medical history</li> <li class="seamTextUnorderedListItem">Blood tests</li> <li class="seamTextUnorderedListItem">Brain tumor survey</li> <li class="seamTextUnorderedListItem">Survey about your well-being and if you have signs of <span class="highlight">anxiety</span> and depression</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Your doctor will discuss your test results with you to recommend treatment options.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT02851706' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li></ul>
3

Registry of People With Brain Metastasis

Evaluation of the Natural History of and Specimen Banking for Patients With Tumors of the Central Nervous System
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Nearest Location:
2433 miles
National Institutes of Health Clinical Center
Bethesda, MD

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Visits:
Number of visits unavailable

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ClinicalTrials.gov: NCT02851706

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Phase NA

4

Web-Based Genetic Counseling for Metastatic Breast Cancer

A Randomized Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Metastatic Breast, Ovarian, Prostate and Pancreatic Cancer Patients

Purpose: To study whether web-based genetic counseling can improve genetic testing knowledge and decrease <span class="highlight">anxiety.</span>

Who is this for?: People with metastatic (stage IV) breast cancer. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will be randomly assigned to 1 of 4 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1: Standard of Care</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visits with a genetic counselor, 2 times, before and after genetic testing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visit with a genetic counselor, 1 time, before genetic testing</li> <li class="seamTextUnorderedListItem">Web-based genetic counseling, 1 time, after genetic testing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Web-based genetic counseling, 1 time, before genetic testing</li> <li class="seamTextUnorderedListItem">Visit with a genetic counselor, 1 time, after genetic testing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 4: Experimental</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Web-based genetic counseling, 2 times, before and after genetic testing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visits with genetic counselors will be either in-person or remote (telephone or video).</li> <li class="seamTextUnorderedListItem">Visits with a genetic counselor before and after genetic testing are considered standard of care. Genetic counselors provide you information about how genetic conditions could affect you or your family.</li> <li class="seamTextUnorderedListItem">Web-based genetic counseling provides your genetic testing results, a detailed summary of what those results mean, and an individualized summary.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04353973' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cdc.gov/genomics/gtesting/genetic_counseling.htm' target='_blank'>CDC: What is Genetic Counseling?</a> </li><li class='seamTextUnorderedListItem'><a href='https://clinicalresearch.itmat.upenn.edu/clinicaltrial/6565/a-randomized-study-of-an-ehealth-delivery-alternative-for-cancer-genetic-testing-for-hereditary-predisposition-in-metastatic-breast-ovarian-prostate-and-pancreatic-cancer-patients/?qd=2667811' target='_blank'>University of Pennsylvania: Trial Information Page</a> </li></ul>
4

Web-Based Genetic Counseling for Metastatic Breast Cancer

A Randomized Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Metastatic Breast, Ovarian, Prostate and Pancreatic Cancer Patients
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Nearest Location:
2517 miles
Abramson Cancer Center at University of Pennsylvania
Philadelphia, PA

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Visits:
4 visits within 6 months

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ClinicalTrials.gov: NCT04353973

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Phase NA

5

Acupuncture and Aromatherapy for Chemotherapy Side Effects for People with Breast Cancer

A Randomized Controlled Trial to Evaluate the Efficacy of Acupuncture Versus Aromatherapy as Treatments to Lessen Nausea, Vomiting and <span class="highlight">Anxiety</span> Associated With Adriamycin and Cytoxan

Purpose: To study the ability of acupuncture or aromatherapy with anti-nausea medication to lessen nausea, vomiting, and <span class="highlight">anxiety</span> side effects of chemotherapy.

Who is this for?: Women with stage I, stage II, stage III, or stage IV (metastatic) breast cancer who are planning to receive treatment with doxorubicin (Adriamycin®) or cyclophosphamide (Cytoxan®) chemotherapy. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will be assigned to 1 of 3 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acupuncture</li> <li class="seamTextUnorderedListItem">Anti-nausea medication</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Aromatherapy</li> <li class="seamTextUnorderedListItem">Anti-nausea medication</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 3</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Anti-nausea medication</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Acupuncture is a form of alternative medicine in which thin needles are inserted into the body.</li> <li class="seamTextUnorderedListItem">Aromatherapy is a form of alternative medicine in which you will inhale aromatic plant extracts and essential oils.</li> <li class="seamTextUnorderedListItem">Anti-nausea medication is standard of care.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04116697' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/complementary-therapy/types/acupuncture' target='_blank'>Breastcancer.org: Acupuncture</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/complementary-therapy/types/aromatherapy' target='_blank'>Breastcancer.org: Aromatherapy</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/resources-support/complementary-integrative-medicine/' target='_blank'>Metastatictrialtalk.org: What is Complementary and Integrative Medicine?</a> </li></ul>
5

Acupuncture and Aromatherapy for Chemotherapy Side Effects for People with Breast Cancer

A Randomized Controlled Trial to Evaluate the Efficacy of Acupuncture Versus Aromatherapy as Treatments to Lessen Nausea, Vomiting and <span class="highlight">Anxiety</span> Associated With Adriamycin and Cytoxan
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Nearest Location:
2566 miles
Englewood Health
Englewood, NJ

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Visits:
Number of visits unavailable

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ClinicalTrials.gov: NCT04116697

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Phase NA

6

CBD for <span class="highlight">Anxiety</span> for People with Metastatic Breast Cancer

Randomized, Double-blind Phase II Study of a Single Dose of Cannabidiol (CBD) for Acute Anticipatory <span class="highlight">Anxiety</span> in Advanced Breast Cancer

Purpose: To study the safety, effects (good and bad), and anti-anxiety activity of an FDA-approved cannabidiol (CBD), Epidiolex®.

Who is this for?: Women with metastatic (stage IV) breast cancer that experience <span class="highlight">anxiety</span> before scans. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cannabidiol (Epidiolex®), by mouth, 1 dose before scan</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Placebo for cannabidiol (Epidiolex®), by mouth, 1 dose before scan</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Additional Procedures</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cannabidiol (CBD) is a component of the cannabis sativa (marijuana) plant and of hemp.</li> <li class="seamTextUnorderedListItem">Studies of CBD have led to its approval by the FDA for certain childhood seizure disorders. Researchers have also been studying the use of CBD to manage <span class="highlight">anxiety</span> and pain.</li> <li class="seamTextUnorderedListItem">Cannabidiol (Epidiolex®) is an FDA-approved seizure drug.</li> <li class="seamTextUnorderedListItem">You will receive either cannabidiol (Epidiolex®) or the placebo before a CT scan or PET scan.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04482244' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938286/' target='_blank'>National Institutes of Health: Cannabidiol (Epidiolex®) Frequently Asked Questions for Patients and Caregivers</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/special-topics/mbc-and-cannabis/' target='_blank'>Metastatic Trial Talk: Cannabis Use For Managing Symptoms and Side Effects</a> </li></ul>
6

CBD for <span class="highlight">Anxiety</span> for People with Metastatic Breast Cancer

Randomized, Double-blind Phase II Study of a Single Dose of Cannabidiol (CBD) for Acute Anticipatory <span class="highlight">Anxiety</span> in Advanced Breast Cancer
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Nearest Location:
2693 miles
Dana Farber Cancer Institute
Boston, MA

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Visits:
1 visit

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ClinicalTrials.gov: NCT04482244

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Phase II