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No travel requiredTrials coming soon to MTSAdditional metastatic cancer trials

1

NEAREST SITE: 0 miles
University of Texas MD Anderson Cancer Center LAO
Houston, TX

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT05198843

Dasatinib With Omega-3 Dietary Supplement for Metastatic Triple Negative Inflammatory Breast Cancer

Phase Ib/II Study of EPA-Based EphA2 Targeted Therapy for Patients With Metastatic Triple-Negative Inflammatory Breast Cancer Scientific Title

Purpose
To study the safety, best dose, effects (good and bad), and anti-cancer activity of dasatinib (Sprycel®), a targeted therapy called a tyrosine kinase inhibitor, with icosapent ethyl (Vascepa®), an omega-3 dietary supplement.
Who is this for?
People with metastatic (stage IV) triple negative (ER-, PR-, HER2-) inflammatory breast cancer (IBC) that has progressed on standard treatment.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®), by mouth, daily</li> <li class="seamTextUnorderedListItem">Icosapent ethyl (Vascepa®), by mouth, daily</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®) is a type of targeted therapy called a tyrosine kinase inhibitor. Tyrosine kinase inhibitors work by blocking proteins that signal cancer cells to multiply, which may help keep cancer cells from growing.</li> <li class="seamTextUnorderedListItem">Dasatinib (Sprycel®) is approved for treatment of other cancers.</li> <li class="seamTextUnorderedListItem">Icosapent ethyl (Vascepa®) is an omega-3 fatty acid dietary supplement. It may decrease the amount of fats made in the <span class="highlight">liver</span> and may reduce the growth of triple negative inflammatory breast cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05198843' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/types/inflammatory' target='_blank'>Breastcancer.org: Inflammatory Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/dasatinib' target='_blank'>Cancer Research UK: Dasatinib (Sprycel®)</a> </li><li class='seamTextUnorderedListItem'><a href='https://medlineplus.gov/druginfo/meds/a613024.html' target='_blank'>MedlinePlus: Icosapent Ethyl (Vascepa®)</a> </li></ul>
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2

NEAREST SITE: 0 miles
MD Anderson Cancer Center
Houston, TX

VISITS: At least 4 visits over 1 month

PHASE: I

NCT ID: NCT00986661

PV-10 Chemoablation for Breast Cancer That Has Spread to The Liver

A Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics of PV-10 Chemoablation of Cancer Metastatic to the Liver or Hepatocellular Carcinoma Not Amenable to Resection or Transplant Scientific Title

Purpose
To look at the safety and effects (good and bad) of a PV-10 injection into the liver.
Who is this for?
People with stage IV (metastatic) breast cancer that has spread to the liver.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PV-10, by injection</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Follow up</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Visits every 3 months for up to 8 years</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">PV-10 targets and concentrates in tumor cells. </li> <li class="seamTextUnorderedListItem">When used along with radiation, it may make radiation more effective. </li> <li class="seamTextUnorderedListItem">It also may get the immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">This study will also include patients who have <span class="highlight">liver</span> cancer or who have other types of cancers that have spread to the <span class="highlight">liver</span>.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT00986661' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://provectusbio.com/pv-10-for-cancers-of-the-liver' target='_blank'>Drug company information page: PV-10 For Cancers of the Liver</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pv-10' target='_blank'>NCI Drug Dictionary: PV-10</a> </li></ul>
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