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1

AsiDNA Oligonucleotide With Olaparib PARP Inhibitor for Advanced HER2- Breast Cancer

A Phase 1b/2 Basket Study To Assess The Safety And Efficacy Of AsiDNA™ In Combination With Olaparib In Participants With Recurrent Solid Tumors <span class="highlight"></span>

Purpose: To study the safety, best dose, effects (good and bad), and anti-cancer activity of AsiDNA, an experimental oligonucleotide, with olaprib (Lynparza®) PARP inhibitor.

Who is this for?: People with advanced (some stage III) or metastatic (stage IV) HER2 negative (HER2-) breast cancer who have received treatment with a PARP inhibitor. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AsiDNA, by IV, daily for 3 days, then weekly</li> <li class="seamTextUnorderedListItem">Olaprib (Lynparza®), by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">AsiDNA is an experimental oligonucleotide (small piece of DNA) that may kill cancer cells.</li> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of targeted therapy called a PARP inhibitor. PARP inhibitors work by blocking the action of poly (ADP-ribose) polymerase, an enzyme that helps repair DNA.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05700669' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onxeo.com/fr/asidna-en/' target='_blank'>Onxeo Drug Information Page: AsiDNA</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted-therapy/lynparza' target='_blank'>Breastcancer.org: Olaprib (Lynparza®)</a> </li></ul>
1

AsiDNA Oligonucleotide With Olaparib PARP Inhibitor for Advanced HER2- Breast Cancer

A Phase 1b/2 Basket Study To Assess The Safety And Efficacy Of AsiDNA™ In Combination With Olaparib In Participants With Recurrent Solid Tumors <span class="highlight"></span>
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Nearest Location:
1481 miles
Next Oncology
San Antonio, TX

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Visits:
Number of visits unavailable

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ClinicalTrials.gov: NCT05700669

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Phase I-II