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1

KB-0742 CDK9 Inhibitor for Advanced Triple Negative Breast Cancer with MYC Overexpression

Phase 1, First-in-human, Open-label Dose Escalation and Cohort Expansion Study of KB-0742 in Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin Lymphoma <span class="highlight"></span>

Purpose: To study the safety, best dose, effects (good and bad), and anti-cancer activity of KB-0742, an experimental CDK9 inhibitor.

Who is this for?: People with advanced (some stage III) or metastatic (stage IV) triple negative (ER-, PR-, HER2-) breast cancer with MYC amplification/overexpression with no standard treatment options available. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">KB-0742, by mouth</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Please contact research site for treatment schedule</i></p>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">KB-0742 is an experimental targeted therapy called a CDK9 inhibitor that may block an enzyme, CDK9, that helps cancer grow.</li> <li class="seamTextUnorderedListItem">Targets or mutations: MYC</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04718675' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.kronosbio.com/pipeline/' target='_blank'>Kronos Bio Drug Information Page: KB-0742</a> </li></ul>
1

KB-0742 CDK9 Inhibitor for Advanced Triple Negative Breast Cancer with MYC Overexpression

Phase 1, First-in-human, Open-label Dose Escalation and Cohort Expansion Study of KB-0742 in Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin Lymphoma <span class="highlight"></span>
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Nearest Location:
336 miles
University of California, Los Angeles (UCLA)
Los Angeles, CA

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Visits:
Number of visits unavailable

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ClinicalTrials.gov: NCT04718675

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Phase I-II