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1

NEAREST SITE: 353 miles
Research Site
Duarte, CA

VISITS: Number of visits unavailable

PHASE: III

NCT ID: NCT04494425

Trastuzumab Deruxtecan or Chemotherapy for Metastatic HR+, HER2-Low Breast Cancer

A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Breast Cancer Patients Whose Disease Has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06) Scientific Title

Purpose
To compare the anti-cancer activity, safety, and side effects of giving trastuzumab deruxtecan (Enhertu®) to giving chemotherapy.
Who is this for?
People with metastatic (stage IV) hormone-positive (ER+ and/or PR+), HER2-Low breast cancer who have already received at least one anti-hormone therapy for metastatic disease.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem"><span class="highlight">Trastuzumab</span> <span class="highlight">deruxtecan</span> (Enhertu®), by IV, ongoing</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Your doctor's choice of <span class="highlight">chemotherapy</span>: capecitabine (Xeloda®), paclitaxel (Taxol®), or nab-paclitaxel (Abraxane®) ongoing</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem"><span class="highlight">Trastuzumab</span> Deruxtican (Enhertu®) is an antibody-drug conjugate (ADC). It targets <span class="highlight">HER2</span> to deliver a <span class="highlight">chemotherapy</span> drug directly to the <span class="highlight">cancer</span> cells. It is approved to treat people with <span class="highlight">metastatic</span> <span class="highlight">HER2</span>+ <span class="highlight">breast</span> <span class="highlight">cancer</span> who have already received two anti-<span class="highlight">HER2</span> therapies. Its use in this trial is considered experimental.</li> <li class="seamTextUnorderedListItem">The chemotherapies capecitabine (Xeloda®), paclitaxel (Taxol®), and nab-paclitaxel (Abraxane®) are all commonly used to treat <span class="highlight">metastatic</span> <span class="highlight">breast</span> <span class="highlight">cancer</span>.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04494425' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/research-news/her2-low-expressing-a-new-subcategory-of-her2-negative-breast-cancer/' target='_blank'>Metastatic Trial Talk: HER2-Low Expressing</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.enhertu.com/en/gastric/?utm_source=google&utm_medium=cpc&utm_campaign=branded+general_2020&utm_content=branded+general_exact&utm_term=trastuzumab+deruxtecan&gclid=cj0kcqias5ecbhcbarisaehk4r7igokn76-yzybu0ziqrknxg5sw-w0t3uyeq-25nhutdetkzoiiwuua' target='_blank'>Daiichi Sankyo Company Drug Information Page: Enhertu® (Fam-Trastuzumab Deruxtican-nxki)</a> </li></ul>
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