In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. Use the contact information in our trial listings to call or email the research site for information about a trial's status.

Visit COVID-19 & Cancer Clinical Trials on Metastatic Trial Talk for regularly updated information about clinical trials during the coronavirus pandemic.

Back to Metastatic Trial Search
Powered by BreastCancerTrials.org

You have matched to trials (Last updated: April 17, 2021)

Zip Code:
 

Narrow my choices:

Radius (miles): All U.S.

20 All U.S.
Treatment    Non-treatment 
Phase    I     II     III 
Display Only New Trials 
 
Close
Treatment

BRCA1/2 (inherited)

Chemotherapy

Hormone Therapy

Radiation Oncology

Targeted Therapy: All

Targeted Therapy: Anti-HER2 Therapy

Targeted Therapy: CDK Inhibitors

Targeted Therapy: PARP Inhibitors

Targeted Therapy: Tumor Mutations

Targeted Therapy: Other Targeted Therapy

Vaccines and Immunotherapy

Other Treatment

Non-Treatment

Activities

Complementary and Alternative Medicine

Decision Support

Genetics/Family History

Lymphedema

Managing Side Effects

No Travel Required

Predicting Response to Treatment

Support/Education

Surveys/Interviews/Registries

Close

AKT

ALK

AR

BARD1

BRCA1/2 (tumor)

BRIP1

CD205

CD70

CHEK2 or CHEK1

ESR1

FGFR

HER2/ERBB2

HLA

MET or C-Met

NTRK

PALB2

PIK3CA or PI3K

PTEN

RAD51

RAF (including BRAF)

RAS (KRAS or NRAS)

RB

ROS1

TP53


1

NEAREST SITE: 2458 miles
Johns Hopkins University
Baltimore, MD

VISITS: Number of visits unavailable, over 3 months

PHASE: NA

NCT ID: NCT04447651

Immunotherapy Treatment Recommendations for People with Advanced Breast Cancer with a SF3B1 Mutation

A Remote-Directed "Virtual" Clinical Trial in Metastatic Breast Cancer to Determine Feasibility of Evaluating Patient Response to Immunotherapy Using Spliceosome Mutational Markers (PRISMM) Scientific Title

Purpose
To study whether a specific tumor mutation (F3B1) can predict who will benefit from receiving a type of immunotherapy called an immune checkpoint inhibitor.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer whose tumor tests positive for a SF3B1 mutation.    Full eligibility criteria
Contact research site
Close

Contact Research Sites

  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">1 or 2 blood draws</li> <li class="seamTextUnorderedListItem">Questionnaires</li> <li class="seamTextUnorderedListItem">Next Generation Sequencing of your tumor</li> <li class="seamTextUnorderedListItem"><span class="highlight">Immunotherapy</span> (checkpoint inhibitor) <span class="highlight">treatment</span> <span class="highlight">recommendations</span> from the Johns Hopkins Molecular Tumor Board</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">An immune checkpoint inhibitor is a type of <span class="highlight">immunotherapy</span> that works by blocking certain proteins (located on <span class="highlight">cancer</span> cells or immune system cells). Once these proteins are blocked, the immune system is then able to see and go after <span class="highlight">cancer</span> cells.</li> <li class="seamTextUnorderedListItem">Target or <span class="highlight">mutation</span>: <span class="highlight">SF3B1</span></li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04447651' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/research-news/breast-cancer-immunotherapy-clinical-trials/' target='_blank'>Metastatic Trial Talk: Immunotherapy & Metastatic Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/immune-checkpoint-inhibitor' target='_blank'>NCI Dictionary of Cancer Terms: Immune Checkpoint Inhibitor</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/from-the-experts/next-generation-sequencing/' target='_blank'>Metastatic Trial Talk: What is Next-Generation Sequencing</a> </li></ul>
See more