What's involved?
<p class="seamTextPara">
You will be randomly assigned to 1 of 6 groups:
</p>
<p class="seamTextPara">
<i class="seamTextEmphasis">Group 1</i>
</p>
<ul class="seamTextUnorderedList">
<li class="seamTextUnorderedListItem">Giredestrant, by mouth, daily, ongoing</li>
</ul>
<p class="seamTextPara">
<i class="seamTextEmphasis">Group 2</i>
</p>
<ul class="seamTextUnorderedList">
<li class="seamTextUnorderedListItem">Giredestrant, by mouth, daily, ongoing</li>
<li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®), by mouth, twice daily, ongoing</li>
</ul>
<p class="seamTextPara">
<i class="seamTextEmphasis">Group 3</i>
</p>
<ul class="seamTextUnorderedList">
<li class="seamTextUnorderedListItem">Giredestrant, by mouth, daily, ongoing</li>
<li class="seamTextUnorderedListItem">Ipatasertib, by mouth, daily (3 weeks on, 1 week off), ongoing</li>
</ul>
<p class="seamTextPara">
<i class="seamTextEmphasis">Group 4</i>
</p>
<ul class="seamTextUnorderedList">
<li class="seamTextUnorderedListItem">Giredestrant, by mouth, daily, ongoing</li>
<li class="seamTextUnorderedListItem"><span class="highlight">Inavolisib,</span> by mouth, daily, ongoing</li>
</ul>
<p class="seamTextPara">
<i class="seamTextEmphasis">Group 5</i>
</p>
<ul class="seamTextUnorderedList">
<li class="seamTextUnorderedListItem">Giredestrant, by mouth, daily, ongoing</li>
<li class="seamTextUnorderedListItem">Ribociclib (Kisqali®), by mouth, daily (3 weeks on, 1 week off), ongoing</li>
</ul>
<p class="seamTextPara">
<i class="seamTextEmphasis">Group 6</i>
</p>
<ul class="seamTextUnorderedList">
<li class="seamTextUnorderedListItem">Giredestrant, by mouth, daily, ongoing</li>
<li class="seamTextUnorderedListItem">Everolimus (Afinitor®), by mouth, daily, ongoing</li></ul>
What's being studied?
<ul class="seamTextUnorderedList">
<li class="seamTextUnorderedListItem">Giredestrant is an experimental anti-estrogen therapy you take by mouth. It is a type of anti-estrogen therapy called a SERD (selective estrogen receptor degrader).</li>
<li class="seamTextUnorderedListItem">SERDs work by binding to and breaking down estrogen receptors. The only SERD currently approved to treat breast cancer is fulvestrant (Faslodex®). Faslodex is given by injection. </li>
<li class="seamTextUnorderedListItem">Abemaciclib (Verzenio®) is a type of targeted therapy called a CDK 4/6 inhibitor -- it blocks two enzymes, CDK4 and CDK6, that help cancer grow. It is already approved to treat some metastatic breast cancer, but its use in this trial is experimental.</li>
<li class="seamTextUnorderedListItem">Ribociclib (Kisqali®) is also a CDK 4/6 inhibitor. It is already approved to treat some metastatic breast cancer, but its use in this trial is experimental.</li>
<li class="seamTextUnorderedListItem">Ipatasertib is an experimental type of targeted therapy called an AKT inhibitor. It may slow or stop cancer cells from growing by blocking the enzyme (protein) AKT. </li>
<li class="seamTextUnorderedListItem">Inavolisib is an experimental type of targeted therapy called a PI3K inhibitor. If there is a mutation in the PIK3CA gene, the PI3K pathway can become overactivated, allowing cancer cells to grow. <span class="highlight">Inavolisib</span> may slow or stop cancer cells from growing by blocking this pathway. </li>
<li class="seamTextUnorderedListItem">Everolimus (Afinitor®) is a type of targeted therapy called an mTOR inhibitor. It works by interfering with a cancer cell's ability to divide and grow.</li></ul>
How can I learn more?
<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04802759' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.genentechoncology.com/pipeline-molecules/serd-3.html' target='_blank'>Genentech Drug Information Page: Giredestrant (GDC-9545)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/targeted_therapies/cdk46-inhibitors' target='_blank'>Breastcancer.org: CDK 4/6 Inhibitors (Abemaciclib & Ribociclib)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.genentechoncology.com/pipeline-molecules/ipatasertib.html' target='_blank'>Genentech Drug Information Page: Ipatasertib (AKT Inhibitor)</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.genentechoncology.com/pipeline-molecules/inavolisib.html' target='_blank'>Genentech Drug Information Page: Inavolisib (P13K Alpha Inhibitor)</a> </li><li class='seamTextUnorderedListItem'><a href='http://chemocare.com/chemotherapy/drug-info/everolimus.aspx' target='_blank'>Chemocare: Everolimus (Afinitor)</a> </li></ul>