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1

<span class="highlight">Artificial</span> Intelligence Guided Treatment Selection for Advanced HR+/HER2- Breast Cancer

<span class="highlight">Artificial</span> Intelligence and Machine Learning-Enhanced Biomarker-dRiven CDK4/6 Inhibitor Rechallenge in HR+ HER2- Advanced Breast Tumors.

Purpose: To see if using an <span class="highlight">artificial</span> intelligence (AI) tool can help identify who may benefit from taking a second CDK4/6 inhibitor.

Who is this for?: People with advanced (some stage III) or metastatic (stage IV) hormone receptor positive (ER+ and/or PR+), HER2 negative (HER2-) breast cancer that has progressed after treatment with a CDK4/6 inhibitor. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">CDK4/6 inhibitor that is different from the one you previously took</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®), by injection, monthly</li> <li class="seamTextUnorderedListItem">Checkups, tests, and questionnaires, monthly</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Treatment chosen by the doctor, but will not include CDK4/6 inhibitors</li> <li class="seamTextUnorderedListItem">Checkups, tests, and questionnaires, monthly</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Palbociclib (Ibrance®), abemaciclib (Verzenio®), ribociclib (Kisqali®) are a type of targeted therapy called CDK 4/6 inhibitors.</li> <li class="seamTextUnorderedListItem">CDK4/6 inhibitors block two enzymes, CDK4 and CDK6, that help cancer grow.</li> <li class="seamTextUnorderedListItem">Fulvestrant (Faslodex®) is a type of hormone therapy called a selective estrogen receptor degrader (SERD). It is approved to treat postmenopausal women with advanced breast cancer.</li> <li class="seamTextUnorderedListItem">Researchers believe that the AI tool will be able to predict who will respond to a second CDK4/6 inhibitor combined with fulvestrant (Faslodex) and that they will have better outcomes (longer progression free survival, higher overall response rate, higher clinical benefit rate, and better quality of life).</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT07227233' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://metastatictrialtalk.org/research-news/cdk-inhibitor-resistance/' target='_blank'>Metastatic Trial Talk: Overcoming Resistance to CDK4/6 Inhibitors</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.breastcancer.org/treatment/hormonal-therapy/faslodex' target='_blank'>Breastcancer.org: Fulvestrant (Faslodex®)</a> </li></ul>
1

<span class="highlight">Artificial</span> Intelligence Guided Treatment Selection for Advanced HR+/HER2- Breast Cancer

<span class="highlight">Artificial</span> Intelligence and Machine Learning-Enhanced Biomarker-dRiven CDK4/6 Inhibitor Rechallenge in HR+ HER2- Advanced Breast Tumors.
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Nearest Location from 94107:
441 miles
University of California, San Diego
La Jolla, CA

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Visits:
Monthly for up to 6 months

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ClinicalTrials.gov: NCT07227233

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Phase II

2

Registry of Mammograms to Improve <span class="highlight">Artificial</span> Intelligence Analysis of Scans

UCF MammoChat: An AI-Driven Platform for Personalized Breast Cancer Patient Support -Image Repository

Purpose: To develop <span class="highlight">artificial</span> intelligence (AI) models to better read diagnostic mammograms.

Who is this for?: People who have received a mammogram. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Provide consent to donate your mammogram.</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Around half of women will receive a false positive mammogram result (a report of cancer when cancer is not actually present). This creates anxiety.</li> <li class="seamTextUnorderedListItem">Artificial intelligence (AI) may be able to better read mammograms to reduce false positive results. AI models need to be improved for different racial groups, age ranges, ethnicities, and different types of breast cancer.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT07214883' target='_blank'>ClinicalTrials.gov</a> </li></ul>
2

Registry of Mammograms to Improve <span class="highlight">Artificial</span> Intelligence Analysis of Scans

UCF MammoChat: An AI-Driven Platform for Personalized Breast Cancer Patient Support -Image Repository
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Nearest Location from 94107:
2446 miles
University of Central Florida
Orlando, FL

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Visits:
No visits required

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ClinicalTrials.gov: NCT07214883

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Phase NA

3

Using <span class="highlight">Artificial</span> Intelligence to Match Patients to Clinical Trials (SYNERGY-AI)

SYNERGY-AI: <span class="highlight">Artificial</span> Intelligence Based Precision Oncology Clinical Trial Matching and Registry

Purpose: To study if a computer that has been taught how to match people to clinical trials <span class="highlight">(artificial</span> intelligence) can help increase enrollment in clinical trials.

Who is this for?: People with advanced (some stage III) or metastatic (stage IV) breast cancer who have already decided to enroll in a clinical trial. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">A clinical trial matching report based on your medical records that you can review with your doctor.</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">This trial will use <span class="highlight">artificial</span> intelligence and virtual tumor boards to help match people to clinical trials.</li> <li class="seamTextUnorderedListItem">The researchers will also create a registry to study the medical and financial effects of this program. </li> <li class="seamTextUnorderedListItem">This is an international trial that is also enrolling people with other types of cancer.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03452774' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://massivebio.com/' target='_blank'>Massive Bio Study Information Page</a> </li></ul>
3

Using <span class="highlight">Artificial</span> Intelligence to Match Patients to Clinical Trials (SYNERGY-AI)

SYNERGY-AI: <span class="highlight">Artificial</span> Intelligence Based Precision Oncology Clinical Trial Matching and Registry
No Travel Required
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Visits:
No visits required

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ClinicalTrials.gov: NCT03452774

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Phase NA

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