International Brain Mets Trials - Currently Recruiting
Brain mets trials that are currently recruiting in the U.S. are included on Metastatic Trial Search. See below for other international brain mets trials that are currently recruiting.
Asia
SWOG S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer (NCT04155034)
Effects of Intravenous Anesthesia and Balanced Anesthesia on Flash Visual Evoked Potentials (NCT04725032)
Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases (NCT04801342)
Toripalimab Combined With Anlotinib and SBRT in Patients With Untreated Brain Metastases of Driven Gene-negative NSCLC (NCT05021328)
Brain Tumor Intraoperative Ultrasound Database (NCT05062772)
Osimertinib Combined With Bevacizumab in Patients With Brain Metastasis Epidermal Growth Factor Receptor (EGFR) Mutation Positive Metastatic Non-Small Cell Lung Cancer (NCT05104281)
Influences of Propofol and Sevoflurane Anesthesia in Brain Tumor (NCT05141877)
Brain Diseases on 7.0T Magnetic Resonance Imaging (NCT05287750)
Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis (NCT05305885)
Blood-brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets (NCT05317858)
Lazertinib in Patients With NSCLC With Asymptomatic or Mild Symptomatic Brain Metastases After Failure of EGFR TKI. (NCT05326425)
Efficacy and Safety of Furmonertinib in Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases: A Single-center, Open-label, Phase II Trial（iFORCE） (NCT05465343)
Evaluation of Clinical Decision Support System for Brain Metastasis Using Brain MR Images (NCT05573815)
Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases (NCT05768490)
The Efficacy and Safety of Eutideron, Etoposide, and Bevacizumab in Patients With Brain Metastases From Breast Cancer. (NCT05781633)
A Study of ABM-1310 in Patients With BRAF V600-Mutant Relapsed and Drug Resistant Primary Malignant Brain Tumors (NCT05892653)
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains (NCT05921786)
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling (NCT05943262)
TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases (NCT05948813)
Prophylactic Cranial Irradiation Versus Observation in Stage IV NSCLC Randomized Controlled Clinical Study (NCT06014450)
Clinical Applicantion of Multi-Tracer PET/MR Imaging in Neurological Disorders/Disease (NCT06092125)
Study of Oral JYP0322 in Patients With Locally Advanced or Metastatic Cancer Targeting ROS1 Molecular Fusion. (NCT06128148)
Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG (NCT06221553)
a Feasibility Study of iHD-SRT for BM (NCT06231186)
WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases (NCT06243003)
Surgical Resection Outcomes in Patients With Brain Metastasis (NCT06318065)
A Study of Trilaciclib Combined With Chemotherapy in the Treatment of Advanced NSCLC With Leptomeningeal Metastasis (NCT06332287)
A Study of Furmonertinib Combined With Chemotherapy in the Treatment of NSCLC With Leptomeningeal Metastasis (NCT06339242)
Australia
HyperArc Registry Study (NCT05270707)
Europe
Comparison of Proton and Photon Radiotherapy of Brain Tumors (ProtoChoice-Hirn) (NCT02824731)
Intraoperative Radiotherapy After the Resection of Brain Metastases (NCT03226483)
Evaluation of 68-GaNOTA-Anti-HER2 VHH1 Uptake in Brain Metastasis of Cancer Patients (NCT03331601)
A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases (NCT03368625)
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer (NCT03423628)
Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients (NCT03694938)
Stereotactic Radiotherapy for Cerebral Metastases With Recent Hemorrhagic Signal (NCT03696680)
Radiotherapy of Multiple Brain Metastases Using AGuIX® (NCT03818386)
Evaluation of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC) With Brain Metastases (NCT03967522)
A Brain Metastases Research Platform to Tackle the Challenge of CNS Metastases in Solid Tumours (NCT04109131)
Brain Areas of Time-To-Contact Perception: an Awake Surgery Study (NCT04128306)
Multimodal Connectome Study of Brain Tumor-operated Patients (NCT04163315)
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery) (NCT04223999)
Metabolic Characterization of Space Occupying Lesions of the Brain (NCT04233788)
Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases (NCT04397978)
Preoperative Stereotactic Radiosurgery for Brain Metastases (NCT04503772)
Postoperative Risk Prediction Score After Elective Intracranial Neurosurgery Operation (NCT04585633)
Use of Non-invasive Optical Analysis in Neurosurgery (NCT04712214)
Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosurgery (NCT04785521)
ASL in Brain Metastasis MRI Following Gamma Knife Treatment (NCT04833335)
Intraoperative Radiotherapy in Patients With Brain Metastases (NCT04847284)
Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection (NCT04857905)
Detection and Metabolic Characterization in DOPA PET/CT of Brain Metastases (NCT04890028)
WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER) (NCT04891471)
Brain Tumor Intraoperative Ultrasound Database (NCT05062772)
IORT After Surgical Resection of Brain Metastases (NCT05084092)
Trial of Preoperative Radiosurgery Versus Postoperative Stereotactic Radiotherapy for Resectable Brain Metastases (NCT05124236)
Hypofractionated Versus Single Fraction Stereotactic Adjuvant Radiotherapy to the Resection Cavity of Brain Metastases (NCT05160818)
The Cognitive-Behavioral Dysfunctions and the Potential of Neuroplasticity in Brain Tumors Patients During Radiotherapy (NCT05192447)
The Cohort for Patient-reported Outcomes, Imaging and Trial Inclusion in Metastatic BRAin Disease (COIMBRA) (NCT05267158)
Vascular Signature Mapping of Brain Tumor Genotypes (NCT05274919)
Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases (NCT05346367)
The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? (NCT05378633)
Interest of a Weekly Consultation by a Medical Electro Radiology Manipulator (MERM) in Addition to the Follow-up by the Radiotherapist to Improve the Collection of Radio-induced Toxicities in Patients Undergoing Proton Therapy (NCT05404308)
Simulation Training in Emergency Department Imaging 2 (NCT05427838)
Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI (NCT05464992)
Functional Navigation in Surgery of Cerebral Tumors and Vascular Malformations (NCT05484219)
Sonography-guided Resection of Brain Mass Lesions (NCT05484245)
Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases (NCT05545007)
Biological Collection of Brain Tumors (NCT05571579)
OPTIMIZATION of ADVANCED MR SEQUENCES (NCT05618990)
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids (NCT05629702)
Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis (NCT05762172)
Comparison of the Analgesic Effects of Scalp Nerve Block and Intravenous Ibuprofen Applications Under the Guidance of Nociception Level Index (NoL) in Patients Undergoing Elective Supratentorial Craniotomy (NCT05763836)
Neuropsychology of Financial Capacity (NCT05791006)
Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin (NCT05793489)
Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries (NCT05819008)
Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors (NCT05831631)
Prehabilitation, Rehabilitation and Comprehensive Approach to the Sequelae of Brain Tumors (NCT05844605)
Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases (NCT05848050)
Contextualized Neuropsychological Rehabilitation for CNS Cancer Survivors: The ImPACT Program (NCT05858359)
HRQoL in Patients With Solid Tumors Treated With Hadrontherapy (NCT05947149)
Evaluation of 3D Ultrasound in Brain Tumor Surgery (NCT05956977)
Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin (NCT05977803)
Stereotactic Radiotherapy Management of Brain Metastases: the Value of a Longitudinal Multimodal Approach (POSTPONE) (NCT06029140)
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy (NCT06051240)
FeelFit: High-intensity Interval Training to Improve Self-reported Physical Fitness in Brain Tumor Patients (NCT06282562)
Autoguide Positioning Device for Multiple Stereotactic Biopsies (NCT06306118)
Improving Social Cognition and Social Behaviour in Various Brain Disorders (NCT06330298)
Determining Postoperative Recovery and the Impact of Adverse Events in Neurosurgery Based on Self-reported, App-based Longitudinal Assessment - a Collaborative Observational Research Project (NCT06352710)
Middle East
A Study to Assess the Efficacy of Cerebellar IMRT Combined With Cerebral SRS in Patients With Brain Metastases (NCT05477316)
Pivotal Study of Proton Radiotherapy Treatments Using Fixed Beam Chair-Based Delivery System (NCT05549414)
North America
Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS) (NCT03324360)
A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases (NCT03368625)
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases (NCT03550391)
CBF and NCF Changes With Brain Radiation (NCT03606421)
Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases (NCT03775330)
SWOG S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer (NCT04155034)
Brain Imaging Biomarkers in Patients With Brain Metastasis (NCT04197297)
FLT-PET / MRI Brain Mets (NCT04244019)
Accelerated Checkpoint Therapy for Any Steroid Dependent Patient With Brain Metastases (NCT04461418)
Pre- Versus Post-operative SRS for Resectable Brain Metastases (NCT04474925)
18F-DOPA II - PET Imaging Optimization (NCT04706910)
BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial (NCT04940507)
Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study (NCT04962672)
RAPid SimPLE Targeted Radiation Treatment for Brain Metastases (NCT05050929)
Blood-brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets (NCT05317858)
Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions (NCT05358340)
Biofeedback for Hemianopia Vision Rehabilitation (NCT05397873)
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies (NCT06229483)
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