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(Last updated: December 03, 2021)

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1

NEAREST SITE: 2293 miles
Carolina BioOncology Institute
Huntsville,NC

VISITS: Every two weeks, ongoing

PHASE: I-II

NCT ID: NCT04875806

Experimental Targeted Therapy NC762 for Advanced Breast Cancer

A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of NC762 in Subjects With Advanced or Metastatic Solid Tumors Scientific Title

Purpose
To study the anti-cancer activity, dose, and side effects of the experimental monoclonal antibody (a type of targeted therapy) NC762.
Who is this for?
People with advanced (some stage III) or metastatic (stage IV) breast cancer.    Full eligibility criteria
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  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NC762, by IV, every 2 weeks, ongoing</li> <li class="seamTextUnorderedListItem">At least 2 tumor biopsies</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NC762 is a type of targeted therapy called a monoclonal antibody.</li> <li class="seamTextUnorderedListItem">Targeted therapies are designed to target proteins on cancer cells without affecting normal cells. Some targeted drugs slow or stop cancer cells from growing; others kill cancer cells, and some trigger the immune system to go after cancer cells. </li> <li class="seamTextUnorderedListItem">Monoclonal antibodies are manufactured immune system proteins designed to attach to a specific target on a cancer cell. Monoclonal antibodies are targeted therapies and, some are also immunotherapies. </li> <li class="seamTextUnorderedListItem">NC762 targets the protein B7-H4. Researchers believe it may kill cancer cells and act as an immunotherapy. </li> <li class="seamTextUnorderedListItem">Immunotherapies are drugs that trigger the immune system to see, go after, and kill cancer cells.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT04875806' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/monoclonal-antibodies.html' target='_blank'>American Cancer Society: Monoclonal Antibodies and Their Side Effects</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.nextcure.com/pipeline/' target='_blank'>NextCure Drug Information Page: NC762</a> </li></ul>
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