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(Last updated: November 13, 2019)

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NEAREST SITE: 2519 miles
Sidney Kimmel Cancer Center at Thomas Jefferson University

VISITS: 2 visits a week for 3 weeks


NCT ID: NCT03955640

Hyperthermia and Olaparib for Breast Cancer That Has Come Back in the Chest Wall

A Pilot Trial of Hyperthermia in Combination With Olaparib in Breast Cancer Patients With Chest Wall Recurrences Scientific Title

To determine the best dose and effects (good and bad) of olaparib (Lynparza®) when it is used along with hyperthermia.
Who is this for?
Women with advanced (some stage III) or metastatic (stage IV) breast cancer who do not have an inherited BRCA mutation and whose cancer has come back in the chest wall.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, twice a day, for 1 month</li> <li class="seamTextUnorderedListItem">Hyperthermia treatment, twice a week, for 3 weeks</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Lynparza is a type of targeted therapy called a PARP inhibitor. </li> <li class="seamTextUnorderedListItem">It is approved to treat patients with an inherited BRCA mutation who have HER2-negative metastatic breast cancer that was previously treated with chemotherapy. </li> <li class="seamTextUnorderedListItem">Hyperthermia is a treatment that uses heat to kill or damage cancer cells. It is being studied in clinical trials.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03955640' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/web-exclusives/fda-approves-olaparib-for-brca-breast-cancer' target='_blank'>OncLive: FDA Approves Olaparib for BRCA+ Breast Cancer</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/hyperthermia.html' target='_blank'>Cancer.org: Hyperthermia to Treat Cancer</a> </li></ul>
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