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(Last updated: November 13, 2019)

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Innovative Clinical Research Institute

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NCT ID: NCT03858972

Tesetaxel and Capecitabine for HER2 negative, HR positive Advanced Breast Cancer

Multinational, Multicenter, Phase 2 Study of Tesetaxel Plus a Reduced Dose of Capecitabine in Patients With HER2 Negative, Hormone Receptor Positive, Locally Advanced or Metastatic Breast Cancer Who Have Not Previously Received a Taxane (CONTESSA 2) Scientific Title

To study the effects (good and bad) of tesetaxel when used with a reduced dose of capecitabine (Xeloda®).
Who is this for?
Women and men with locally advanced (some stage III) or metastatic (stage IV) breast cancer that is ER positive and HER2 negative and have not been previously treated with a taxane.    Full eligibility criteria
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  • <p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel, by mouth, once every 3 weeks</li> <li class="seamTextUnorderedListItem">Capecitabine (Xeloda®), by mouth, twice a day for 14 out of every 21 days</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Tesetaxel is a new type of taxane chemotherapy drug that can be taken by mouth. </li> <li class="seamTextUnorderedListItem">The taxanes that are currently approved are all given intraveneously (IV). </li> <li class="seamTextUnorderedListItem">Xeloda® is an oral chemotherapy drug approved to treat advanced breast cancer.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03858972' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.odonate.com/tesetaxel' target='_blank'>Sponsor site: Tesetaxel</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.webmd.com/drugs/2/drug-7777/capecitabine-oral/details' target='_blank'>WebMD: Capecitabine</a> </li></ul>
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