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(Last updated: October 21, 2020)

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NEAREST SITE: 2539 miles
Memoral Sloan Kettering Basking Ridge
Basking Ridge,NJ

VISITS: 1 visit every other day for 6 or 10 days, then visits coincide with standard treatment

PHASE: II

NCT ID: NCT03808662

SBRT Radiation Therapy for Oligoprogressive Metastatic Breast Cancer

A Randomized Phase II Study Assessing the Efficacy of Local Ablative Radiation Therapy for Metastatic Breast and Lung Cancer Patients With Oligoprogressive Disease Scientific Title

Purpose
To evaluate the safety and effects (good and bad) of using stereotactic body radiation therapy (SBRT) to treat each site of metastases.
Who is this for?
People with oligoprogessive metastatic (stage IV) triple negative (ER-, PR- and HER2-) or hormone receptor positive (ER+ and/or PR+) breast cancer that has progressed on at least one other systemic treatment.    Full eligibility criteria
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  • What's involved?
  • What's being studied?
  • How can I learn more?
  • <p class="seamTextPara"> You will be randomly assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Stereotactic body radiation therapy (SBRT), every other day, for 3 or 5 sessions</li> <li class="seamTextUnorderedListItem">followed by standard of care treatment (decided by you and your physician)</li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2:</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Standard of care treatment (decided by you and your physician)</li></ul>
  • <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Patients with oligoprogressive metastatic breast cancer have a small number of metastatic tumors in one or two other parts of the body. </li> <li class="seamTextUnorderedListItem">This study will compare the safety and effects (good or bad) of using stereotactic body radiation therapy (SBRT) to treat each site of metastases followed by a standard of care treatment, to a standard of care treatment alone. </li> <li class="seamTextUnorderedListItem">SBRT uses multiple radiation beams to deliver high doses of precision radiation directly to the tumor.</li></ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03808662' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.uclahealth.org/radonc/faqs-sbrt' target='_blank'>UCLA Health: SBRT FAQs</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/diagnosis-treatment/cancer-treatments/radiation-therapy/what-sbrt' target='_blank'>Memorial Sloan Kettering Cancer Center: What is SBRT?</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oligometastasis' target='_blank'>NCI Dictionary of Cancer Terms: Oligometastasis</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.mskcc.org/cancer-care/clinical-trials/18-431' target='_blank'>Memorial Sloan Kettering Cancer Center: Study information</a> </li></ul>
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