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(Last updated: November 13, 2019)

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1

NEAREST SITE: 538 miles
Providence Portland Medical Center - Portland
Portland,OR

VISITS: Number of visits unavailable

PHASE: I-II

NCT ID: NCT03435640

NKTR-262 and NKTR-214 with or without Opdivo for Advanced TNBC (and Other) Cancers

A Phase 1/2, Open-label, Multicenter, Dose Escalation and Dose Expansion Study of NKTR-262 in Combination With NKTR-214 and in Combination With NKTR-214 Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies (REVEAL) Scientific Title

Purpose
To evaluate the safety and best dose of two experimental immunotherapy drugs when they are given with or without the immunotherapy drug nivolumab (Opdivo®) to treat advanced breast cancer.
Who is this for?
Women and men with advanced (some stage III) or metastatic (stage IV) breast cancer that is triple negative breast cancer.    Full eligibility criteria
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  • What's being studied?
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  • <p class="seamTextPara"> You will be assigned to 1 of 2 groups: </p> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 1</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NKTR-262, by injection, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">NKTR-214, by IV, every 3 weeks, ongoing </li> </ul> <p class="seamTextPara"> <i class="seamTextEmphasis">Group 2</i> </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">NKTR-262, by injection, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">NKTR-214, by IV, every 3 weeks, ongoing </li> <li class="seamTextUnorderedListItem">Nivolumab (Opdivo®), by IV, every 3 weeks, ongoing</li></ul>
  • <p class="seamTextPara"> INKTR-262 and NKTR-214 are the experimental immunotherapy drugs being used in this study. </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Opdivo is a type of immunotherapy drug called a PD-1 inhibitor. It is approved to treat certain types of metastatic melanoma and non-small cell lung cancer.</li> </ul>
  • <ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT03435640' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='http://www.onclive.com/web-exclusives/nktr-214-nivolumab-combination-shows-promise-in-early-study' target='_blank'>OncLive: NKTR-214 and Nivolumab</a> </li></ul>
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